Pill formula for treating osteoarticular diseases and preparation process

Abstract

The invention discloses a formula of a pill for treating osteoarticular diseases and a preparation process of the pill for treating osteoarticular diseases. Comprising 1-6 parts of pseudo-ginseng, 6-15 parts of turmeric, 6-15 parts of angelica sinensis, 6-15 parts of achyranthes bidentata, 6-15 parts of safflower carthamus, 6-15 parts of impatiens balsamina, 3-9 parts of pawpaw, 6-15 parts of cassia twig, 3-9 parts of ramulus mori, 3-9 parts of rhizoma drynariae, 3-9 parts of pericarpium citri reticulatae, 3-9 parts of rhizoma zingiberis, 1-6 parts of radix angelicae and 3-9 parts of herba epimedii. The oral pill for treating osteoarticular diseases provided by the invention has the effects of promoting blood circulation to remove blood stasis, clearing damp and relieving pain, dredging channels and collaterals, tonifying kidney yang, strengthening muscles and bones, warming interior to dispel cold, eliminating dampness and the like, has a remarkable curative effect on symptoms such as red and swollen and claudication around joints caused by arthritis, and is better in drug effect absorption compared with an externally applied ointment or patch; the traditional Chinese medicine composition can shorten the treatment cycle and is suitable for treating osteoarticular diseases or relieving arthralgia caused by the osteoarticular diseases.

Description

Technical Field

[0001] The invention relates to the field of medicine, and in particular to a pill formula for treating bone and joint diseases and a preparation process thereof. Background Art

[0002] Bone and joint diseases include degenerative arthritis, bursitis, synovitis, cervical spondylosis, lumbar spondylosis, frozen shoulder, bone hyperplasia, rheumatoid arthritis, rheumatoid arthritis, etc. The main symptom of bone and joint diseases is joint pain. The pain occurs during activities and disappears or improves after rest. During acute attacks, the pain worsens, and there may be joint swelling, joint stiffness, and friction sounds within the joints.

[0003] At present, the treatment of bone and joint diseases mostly adopts external ointments or patches. Although it can relieve pain symptoms in a short time, the drug absorption is poor and the treatment cycle is long. Therefore, we propose a pill formula and preparation process for treating bone and joint diseases. Summary of the invention

[0004] The purpose of the present invention is to provide a pill formula and preparation process for treating bone and joint diseases to solve the problems raised in the above background technology.

[0005] To achieve the above object, the present invention provides the following technical solutions:

[0006] On one hand, the present invention provides a pill for treating bone and joint diseases. The formula of the pill, calculated by weight, comprises 1-6 parts of Panax notoginseng, 6-15 parts of turmeric, 6-15 parts of angelica, 6-15 parts of Rhizoma Cyperi, 6-15 parts of safflower, 6-15 parts of Impatiens balsamina, 3-9 parts of papaya, 6-15 parts of cassia twig, 3-9 parts of mulberry twig, 3-9 parts of Rhizoma Drynariae, 3-9 parts of dried tangerine peel, 3-9 parts of dried ginger, 1-6 parts of Angelica dahurica, 3-9 parts of Epimedium, 3-9 parts of Morinda officinalis, 3-9 parts of Eucommia ulmoides, 3-9 parts of Cuscuta australis, 6-15 parts of Rehmannia glutinosa, 6-15 parts of Lycium barbarum, 3-9 parts of Fructus Aurantii Immaturus, 3-9 parts of Rhizoma Cyperi, and 10-20 parts of calcium caseinate.

[0007] As a further scheme of the present invention: the formula of the above-mentioned pills, calculated by weight, includes 2-5 parts of Panax notoginseng, 7-12 parts of turmeric, 7-12 parts of Angelica sinensis, 7-12 parts of Achyranthes bidentata, 7-12 parts of Carthamus tinctorius, 7-12 parts of Impatiens balsamina, 4-7 parts of Papaya, 7-12 parts of cinnamon twig, 4-7 parts of Mori twig, 4-7 parts of Drynaria fortunei, 4-7 parts of dried orange peel, 4-7 parts of dried ginger, 1-6 parts of Angelica dahurica, 4-7 parts of Epimedium, 4-7 parts of Morinda officinalis, 4-7 parts of Eucommia ulmoides, 4-7 parts of Cuscuta australis, 7-12 parts of Rehmannia glutinosa, 7-12 parts of Lycium barbarum, 4-7 parts of Fructus Aurantii Immaturus, 4-7 parts of Cyperus rotundus, and 10-20 parts of calcium caseinate.

[0008] As a further scheme of the present invention: the formula of the pills, calculated by weight, includes 3 parts of Panax notoginseng, 9 parts of turmeric, 9 parts of angelica, 9 parts of Achyranthes bidentata, 9 parts of safflower, 9 parts of Impatiens balsamina, 6 parts of papaya, 9 parts of cinnamon twig, 6 parts of mulberry twig, 6 parts of Drynaria fortunei, 6 parts of dried tangerine peel, 6 parts of dried ginger, 3 parts of Angelica dahurica, 6 parts of Epimedium, 6 parts of Morinda officinalis, 6 parts of Eucommia ulmoides, 6 parts of Cuscuta australis, 9 parts of Rehmannia glutinosa, 9 parts of Lycium barbarum, 6 parts of Fructus Aurantii Immaturus, 6 parts of Cyperus rotundus, and 12 parts of calcium caseinate.

[0009] Another aspect of the present invention provides a process for preparing the above-mentioned pills for treating bone and joint diseases, comprising the following steps:

[0010] Step 1: Weigh the raw materials in the formula, wash and dry the raw materials except calcium caseinate, and then prepare them for use;

[0011] Step 2: Crush and sieve turmeric, Chinese angelica, Chinese rhizome, safflower, impatiens, papaya, cinnamon twig, mulberry twig, bone drynaria, dried ginger, angelica dahurica, epimedium, Morinda officinalis, Eucommia ulmoides, dodder seed, rehmannia glutinosa and cyperus rotundus, put them into a sealed container, inject ethanol into the container and seal it for 15-30 days to obtain a mixture A;

[0012] Step 3: extract the supernatant of mixture A to recover ethanol, and concentrate under reduced pressure to obtain a thick paste;.

[0013] Step 4: crush and sieve the Panax notoginseng, dried tangerine peel, wolfberry and fructus aurantii, and mix them with calcium caseinate to obtain a mixture B;

[0014] Step 5: The thick paste mixture B is fully mixed and made into pills to obtain pills for treating bone and joint diseases.

[0015] As a further solution of the present invention: the Fructus Aurantii Immaturus is prepared by the bran frying method, stir-frying on medium heat, and fumigating with wheat bran to change the medicinal properties of the Fructus Aurantii Immaturus and alleviate its harsh nature, and the weight ratio of the Fructus Aurantii Immaturus to the wheat bran is 100:15.

[0016] As a further solution of the present invention: the Eucommia ulmoides is prepared by salt water roasting method, the Eucommia ulmoides and the salt water are mixed evenly, and after the salt water is completely absorbed, the Eucommia ulmoides is stir-fried over low heat until the white silk in the Eucommia ulmoides skin can be gently torn apart, and then the Eucommia ulmoides is ready to be served, and the weight ratio of the Eucommia ulmoides to the salt is 100:2.

[0017] As a further solution of the present invention: the processing method of dried ginger is: heat river sand with high fire until it is smooth, then add dried ginger of different sizes, turn it over appropriately, until the dried ginger swells and emits a strong aroma.

[0018] As a further solution of the present invention: papaya is prepared by a wine roasting method, papaya slices are mixed with rice wine until the rice wine is completely absorbed, and then fried on a slow fire until dry and removed from the pan, wherein the weight ratio of papaya to rice wine is 100:20.

[0019] As a further solution of the present invention: in the step 2, the raw material needs to be sieved through a 50-80 mesh sieve after being crushed, the ethanol concentration is 75-90%, and the solid-liquid ratio of the raw material to ethanol is 1:2-5.

[0020] As a further solution of the present invention: in the step 4, the raw material needs to be sieved through a 250 sieve after being crushed.

[0021] Compared with the prior art, the present invention has the following beneficial effects:

[0022] The present invention provides an oral pill for treating bone and joint diseases, which has the effects of promoting blood circulation and removing blood stasis, removing dampness and relieving pain, unblocking meridians, tonifying kidney yang, strengthening tendons and bones, warming the interior and dispelling cold, and drying dampness, and has significant therapeutic effects on symptoms such as redness and swelling around joints and lameness caused by arthritis. Compared with externally applied ointments or patches, the pill has better drug absorption and can shorten the treatment cycle, and is suitable for treating bone and joint diseases or alleviating joint pain caused by bone and joint diseases. DETAILED DESCRIPTION

[0023] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention more clearly understood, the present invention will be further described in detail below in conjunction with embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not used to limit the present invention.

[0024] It should be noted that when an element is referred to as being "fixed to" or "disposed on" another element, it can be directly on the other element or indirectly on the other element. When an element is referred to as being "connected to" another element, it can be directly connected to the other element or indirectly connected to the other element.

[0025] It should be understood that the terms "upper", "lower", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside" and "outside" etc., indicating directions or positional relationships, are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific direction, be constructed and operate in a specific direction as described in the specification, and therefore should not be understood as limiting the present invention.

[0026] In addition, the terms "first", "second", and "third" are used for descriptive purposes only and should not be understood as indicating or implying relative importance or implicitly indicating the number of the indicated technical features. Thus, a feature defined as "first" or "second" may explicitly or implicitly include one or more of the features.

[0027] The invention provides a pill for treating bone and joint diseases. The formula of the pill comprises, by weight, 1-6 parts of Radix Notoginseng, 6-15 parts of Curcuma Longa, 6-15 parts of Angelica Sinensis, 6-15 parts of Rhizoma Cyperi, 6-15 parts of Carthamus Tinctorius, 6-15 parts of Impatiens Balsamina, 3-9 parts of Papaya, 6-15 parts of Cinnamomum cassia, 3-9 parts of Mori Branch, 3-9 parts of Drynariae Rhizoma, 3-9 parts of Tangerine Peel, 3-9 parts of Dried Ginger, 1-6 parts of Angelica Dahurica, 3-9 parts of Epimedium, 3-9 parts of Morinda Officinalis, 3-9 parts of Eucommia, 3-9 parts of Cuscuta Semen, 6-15 parts of Rehmannia glutinosa, 6-15 parts of Lycium Barbarum, 3-9 parts of Fructus Aurantii Immaturus, 3-9 parts of Cyperus Rhizoma, and 10-20 parts of calcium caseinate; wherein,

[0028] Panax notoginseng is the dried root of Panax notoginseng, a plant of the Araliaceae family. It has the effects of removing blood stasis and stopping bleeding, promoting blood circulation and relieving pain. It is mainly used to treat bleeding, traumatic injuries, blood stasis and swelling and pain, etc.

[0029] Turmeric is the dried rhizome of the ginger plant turmeric. It is dug up in winter when the stems and leaves wither, washed, boiled or steamed until thoroughly cooked, dried in the sun, and the fibrous roots are removed. It tastes pungent and bitter, and is warm in nature. It enters the spleen and liver meridians, has the effects of breaking blood and promoting qi, dredges the menstruation and relieves pain, and is often used for chest and flank pain, chest obstruction and heart pain, dysmenorrhea, amenorrhea, abdominal masses, rheumatic shoulder and arm pain, and swelling and pain from falls, etc.

[0030] Angelica sinensis is the dried root of the Umbelliferae plant Angelica sinensis, which has the effects of nourishing blood and activating blood circulation, regulating menstruation and relieving pain, and moistening the intestines and relieving constipation. It is often used for blood deficiency and sallow complexion, dizziness and palpitations, irregular menstruation, amenorrhea and dysmenorrhea, abdominal pain due to deficiency and cold, rheumatic arthralgia, traumatic injuries, carbuncle sores, dry intestines and constipation, etc.

[0031] Achyranthes bidentata contains a large amount of alkaloids, which can nourish the liver and kidney, strengthen the tendons and bones, dredge the meridians, and disperse bad blood. It is often used in the clinic to treat cold and dampness, waist and knee pain, soreness of the waist and knees, cramps of the limbs, irregular menstruation, abdominal pain due to blood stasis after childbirth, hematuria, traumatic injury, and knee flexion disorder. It is one of the commonly used drugs for dredge meridians and activate blood circulation in traditional Chinese medicine prescriptions.

[0032] Safflower is the dried flower of the safflower plant of the Asteraceae family. It is picked in summer when the flowers turn from yellow to red, and dried in the shade or in the sun. It has the effects of promoting blood circulation and menstruation, dispersing blood stasis and relieving pain. It is used for amenorrhea, dysmenorrhea, lochia retention, abdominal masses, chest pain, abdominal pain due to blood stasis, stabbing pain in the chest and ribs, injuries from falls, swelling and pain in sores, etc.

[0033] Impatiens balsamina is the whole herb of Impatiens balsamina, a plant of the Impatiens family. It has the effects of dispelling wind, promoting blood circulation, reducing swelling and relieving pain. It is mainly used to treat joint rheumatic pain, traumatic injuries, scrofula, carbuncle, furuncle, etc.

[0034] Papaya is the dried nearly mature fruit of the Malus pedunculata plant of the Rosaceae family. It is harvested when the fruit is green and yellow in summer and autumn, scalded in boiling water until the skin turns grayish white, and then cut in half longitudinally. It has the effects of relaxing muscles and tendons, harmonizing the stomach and removing dampness. It is used to treat dampness and cramps, soreness and pain in the waist and knee joints, vomiting and diarrhea due to summer dampness, cramps and pain, beriberi and edema, etc. In this recipe, the papaya is prepared by the wine-roasting method. The papaya slices are mixed with rice wine until the rice wine is absorbed, and then stir-fried over low heat until dry. The purpose of roasting papaya with wine is mainly to introduce the medicine into the blood and enhance the rheumatic and analgesic effects of papaya. The ratio of papaya to rice wine is 100:20.

[0035] Cinnamon twigs are the dried young branches of the cinnamon bark plant of the Lauraceae family. The young branches are cut in spring and summer, dried in the sun or in the shade, and cut into thin slices or small pieces for use. It tastes spicy and sweet, is warm in nature, and enters the heart, lung, and bladder meridians; it has the effects of sweating and relieving muscles, warming and unblocking meridians, assisting yang and transforming qi, and balancing and descending qi. It is often used for colds, cold pain in the abdomen, amenorrhea due to blood cold, joint pain, phlegm and fluid retention, edema, palpitations, etc.

[0036] Mulberry branches are the dried young branches of the mulberry plant of the Moraceae family. They are harvested in late spring and early summer, with leaves removed and sun-dried, or sliced ​​while fresh and sun-dried. They taste slightly bitter and are neutral in nature. They belong to the liver meridian. They have the effect of removing rheumatism and benefiting joints. They are used for rheumatic arthritis, shoulder, arm, joint pain and numbness, etc.

[0037] Drynaria is bitter in taste and warm in nature. It enters the kidney and liver meridians. It has the effects of tonifying the kidney and strengthening bones, healing injuries and relieving pain. It is used for kidney deficiency and low back pain, tinnitus and deafness, loose teeth, falls and sprains, tendon fractures, etc. In this formula, the drynaria is scalded. The river sand is heated with high heat until it is smooth, and then the drynaria of different sizes is added. Stir-fry repeatedly until the medicinal material swells and then it can be taken out of the pot. It is repeatedly sieved and knocked in the hot sand until the fluff falls off. The main function of sand scalding of drynaria is to knock off the surface fluff and remove the non-medicinal parts of the medicinal material. At the same time, the texture is loose after swelling, which is easy to decoct the medicinal ingredients, enhancing its effect of tonifying the liver and kidney and strengthening the tendons and bones.

[0038] Tangerine peel is the dried mature peel of the citrus plant and its cultivated varieties of the Rutaceae family. The mature fruits are picked, the peel is peeled, and dried in the sun or at low temperature. It tastes bitter and spicy and is warm in nature. It enters the lung and spleen meridians. It has the effects of regulating qi and strengthening the spleen, drying dampness and resolving phlegm. It is often used to treat abdominal distension, loss of appetite, vomiting and diarrhea, and cough with excessive phlegm.

[0039] Dried ginger has the effects of warming the middle and dispersing cold, restoring yang and unblocking meridians, warming the lungs and transforming fluid. It is mainly used for cold pain in the abdomen, vomiting and diarrhea, cold limbs and weak pulse, asthma and cough caused by cold fluid, etc. Use high heat to heat the river sand until it is smooth, then add the dried ginger of different sizes, turn it over appropriately until the dried ginger swells and emits a strong aroma, then take out the roasted ginger. Roasted ginger mainly uses the heat of the river sand to make the dried ginger swell, making it easier to fry the ingredients and alleviate its dryness;

[0040] Angelica dahurica, the dried root of the Umbelliferae plant Angelica dahurica or Angelica dahurica; it has the functions of removing diseases and dampness, draining pus and promoting tissue regeneration, promoting blood circulation and relieving pain, and is mainly used to treat colds, headaches, rhinitis, toothaches, red and white vaginal discharge, painful boils, swellings and toxins, etc.

[0041] Epimedium, also known as Xianlingpi and Gangqian, is the dried leaves of the Berberidaceae plants Epimedium, Tripterygium wilfordii, Soft-haired Epimedium, or Korean Epimedium. It has the effects of tonifying kidney yang, strengthening tendons and bones, and removing rheumatism. It is used for impotence and spermatorrhea, tendon and bone weakness, rheumatic pain, numbness and cramps caused by kidney yang deficiency. It is a commonly used Chinese medicine in clinical practice.

[0042] Morinda officinalis is the dried root of Morinda officinalis, a plant of the Rubiaceae family. It can be dug up all year round, washed, the fibrous roots removed, dried in the sun until 60% to 70% dry, gently pounded, and dried in the sun. It has the effects of tonifying kidney yang, strengthening tendons and bones, and removing rheumatism. It is often used for impotence and spermatorrhea, uterine coldness and infertility, irregular menstruation, lower abdominal cold pain, rheumatic arthralgia, and tendon and bone weakness.

[0043] Eucommia is the bark of Eucommia ulmoides, a plant of the Eucommia family. Between Qingming and the Summer Solstice, select plants that have grown for more than 15 to 20 years, peel off the bark according to the size of the medicinal material, remove the rough skin, dry it in the sun, and place it in a ventilated and dry place. Its functions and indications are: nourishing the liver and kidneys, strengthening the tendons and bones, calming the fetus, treating soreness of the waist and spine, weakness of the feet and knees, residual urine, itching under the genitals, miscarriage, restless fetuses, high blood pressure, etc. In this recipe, Eucommia ulmoides is roasted with salt water. First, mix the Eucommia ulmoides with salt water, wait until the salt water is absorbed, stir-fry over low heat until dry, and until the white silk in the Eucommia ulmoides bark can be gently torn off, then it can be served. Roasting Eucommia ulmoides with salt can lead the medicine into the kidney meridian, enhancing the effect of Eucommia ulmoides in nourishing the liver and kidneys and strengthening the tendons and bones. The ratio of Eucommia ulmoides to salt is 100:2.

[0044] Cuscuta australis, the dried mature seeds of Cuscuta australis or Cuscuta australis of the Convolvulaceae family; it has the effects of nourishing the liver and kidney, consolidating semen and reducing urine, calming the fetus, improving eyesight, and stopping diarrhea. When used externally, it has the effects of eliminating wind and removing spots; it is often used for liver and kidney deficiency, soreness of the waist and knees, impotence and spermatorrhea, enuresis and frequent urination, kidney deficiency and fetal leakage, restless fetal movement, blurred vision and tinnitus, and spleen and kidney deficiency diarrhea;

[0045] Rehmannia glutinosa, also known as Rehmannia glutinosa, is the rhizome of Rehmannia glutinosa or Rehmannia glutinosa of the Scrophulariaceae family, which is processed and steamed and dried. It has the functions of nourishing yin and blood; it can treat yin deficiency and blood deficiency, weakness of waist and knees, fatigue cough and bone steaming, spermatorrhea, metrorrhagia, irregular menstruation, thirst, frequent urination, deafness, blurred vision, etc.

[0046] Citrus aurantium is the dried immature fruit of the plant Citrus aurantium and its cultivated varieties of the Rutaceae family. It is harvested in July when the peel is still green, cut into two halves from the middle, and dried in the sun or at a low temperature. It has the effects of regulating qi, relieving fullness, and relieving stagnation and swelling. It is often used for chest and flank qi stagnation, fullness and pain, indigestion, phlegm and fluid retention, and sagging organs. In this formula, the Citrus aurantium is prepared by the bran frying method, stir-frying on medium heat, and fumigating with wheat bran to change the medicinal properties of the Citrus aurantium, alleviate its harsh nature, and at the same time strengthen the spleen and nourish the stomach. The compatibility ratio of Citrus aurantium to wheat bran is 100:15.

[0047] Cyperus rotundus is the dried rhizome of Cyperus rotundus, a plant of the Cyperaceae family. It is dug in autumn, burned to remove the hair, boiled in boiling water or steamed thoroughly and then dried, or burned and then directly dried; it belongs to the liver, spleen, and triple burner meridians, and has the effects of soothing the liver and relieving depression, regulating qi and relieving fullness, regulating menstruation and relieving pain. It is used for liver depression and qi stagnation, chest and flank distension and pain, hernia pain, breast distension and pain, spleen and stomach qi stagnation, abdominal distension, fullness and pain, irregular menstruation, amenorrhea and dysmenorrhea, etc.

[0048] Calcium caseinate is ionic calcium, and it is stably combined with the phosphate residue of serine in casein, making it an ideal calcium supplement. It is easily absorbed and utilized by the human body, and does not require vitamin D. In addition, due to its specific functional properties such as thickening, viscosity, emulsification, and foaming properties, calcium caseinate can be well added to food.

[0049] The preparation process of the above-mentioned pill for treating bone and joint diseases comprises the following steps:

[0050] Step 1: Weigh the raw materials in the formula, wash and dry the raw materials except calcium caseinate, and then prepare them for use;

[0051] Step 2: Crush and sieve turmeric, Chinese angelica, Chinese rhizome, safflower, impatiens, papaya, cinnamon twig, mulberry twig, bone drynaria, dried ginger, angelica dahurica, epimedium, Morinda officinalis, Eucommia ulmoides, dodder seed, rehmannia glutinosa and cyperus rotundus, put them into a sealed container, inject ethanol into the container and seal it for 15-30 days to obtain a mixture A;

[0052] Step 3: extract the supernatant of mixture A to recover ethanol, and concentrate under reduced pressure to obtain a thick paste;.

[0053] Step 4: crush and sieve the Panax notoginseng, dried tangerine peel, wolfberry and fructus aurantii, and mix them with calcium caseinate to obtain a mixture B;

[0054] Step 5: The thick paste mixture B is fully mixed and made into pills to obtain pills for treating bone and joint diseases.

[0055] Embodiment 1:

[0056] Step 1: weigh 3 parts of Panax notoginseng, 9 parts of turmeric, 9 parts of angelica, 9 parts of Chinese rhizoma cyperi, 9 parts of safflower, 9 parts of impatiens, 6 parts of papaya, 9 parts of cinnamon twig, 6 parts of mulberry twig, 6 parts of drynaria, 6 parts of dried orange peel, 6 parts of dried ginger, 3 parts of angelica, 6 parts of epimedium, 6 parts of Morinda officinalis, 6 parts of Eucommia ulmoides, 6 parts of Cuscuta australis, 9 parts of Rehmannia glutinosa, 9 parts of wolfberry, 6 parts of Citrus aurantium, 6 parts of Cyperus rotundus, and 12 parts of calcium caseinate, wash and dry the raw materials except calcium caseinate, and then prepare them for use;

[0057] Step 2: crush turmeric, angelica, Chinese clematis, safflower, impatiens, papaya, cassia twig, mulberry twig, drynaria, dried ginger, angelica dahurica, epimedium, Morinda officinalis, Eucommia ulmoides, dodder seed, prepared rehmannia and cyperus rotundus, pass through a 50-mesh sieve, put into a sealed container, inject ethanol into the container and seal and soak for 15-30 days to obtain a mixture A, wherein the ethanol concentration is 75%, and the solid-liquid ratio of the raw materials to the ethanol is 1:3;

[0058] Step 3: extract the supernatant of mixture A to recover ethanol, and concentrate under reduced pressure to obtain a thick paste;.

[0059] Step 4: crushing Panax notoginseng, dried tangerine peel, wolfberry and fructus aurantii through a 250 sieve and mixing with calcium caseinate to obtain a mixture B;

[0060] Step 5: The thick paste mixture B is fully mixed and made into pills to obtain pills for treating bone and joint diseases.

[0061] Embodiment 2:

[0062] Step 1: weigh 4 parts of Panax notoginseng, 8 parts of turmeric, 9 parts of angelica, 8 parts of Chinese rhizoma cyperi, 10 parts of safflower, 10 parts of impatiens, 7 parts of papaya, 9 parts of cinnamon twig, 5 parts of mulberry twig, 6 parts of drynaria, 5 parts of dried orange peel, 6 parts of dried ginger, 4 parts of angelica dahurica, 7 parts of epimedium, 7 parts of Morinda officinalis, 5 parts of Eucommia ulmoides, 5 parts of Cuscuta australis, 11 parts of Rehmannia glutinosa, 9 parts of wolfberry, 5 parts of Citrus aurantium, 7 parts of Cyperus rotundus, and 15 parts of calcium caseinate, wash and dry the raw materials except calcium caseinate, and then prepare them for use;

[0063] Step 2: crush turmeric, angelica, Chinese clematis, safflower, impatiens, papaya, cassia twig, mulberry twig, drynaria, dried ginger, angelica dahurica, epimedium, Morinda officinalis, Eucommia ulmoides, dodder seed, prepared rehmannia and cyperus rotundus, pass through a 50-mesh sieve, put into a sealed container, inject ethanol into the container and seal and soak for 15-30 days to obtain a mixture A, wherein the ethanol concentration is 75%, and the solid-liquid ratio of the raw materials to the ethanol is 1:3;

[0064] Step 3: extract the supernatant of mixture A to recover ethanol, and concentrate under reduced pressure to obtain a thick paste;.

[0065] Step 4: crushing Panax notoginseng, dried tangerine peel, wolfberry and fructus aurantii through a 250 sieve and mixing with calcium caseinate to obtain a mixture B;

[0066] Step 5: The thick paste mixture B is fully mixed and made into pills to obtain pills for treating bone and joint diseases.

[0067] Embodiment 3:

[0068] Step 1: weigh 3 parts of Panax notoginseng, 7 parts of turmeric, 10 parts of angelica, 9 parts of Chinese rhizoma cyperi, 9 parts of safflower, 11 parts of impatiens, 4 parts of papaya, 12 parts of cinnamon twig, 6 parts of mulberry twig, 5 parts of drynaria, 8 parts of dried orange peel, 9 parts of dried ginger, 3 parts of angelica, 4 parts of epimedium, 7 parts of Morinda officinalis, 6 parts of Eucommia, 8 parts of Cuscuta, 10 parts of Rehmannia glutinosa, 12 parts of wolfberry, 8 parts of Citrus aurantium, 4 parts of Cyperus rotundus, and 16 parts of calcium caseinate, wash and dry the raw materials except calcium caseinate, and then prepare them for use;

[0069] Step 2: crush turmeric, angelica, Chinese clematis, safflower, impatiens, papaya, cassia twig, mulberry twig, drynaria, dried ginger, angelica dahurica, epimedium, Morinda officinalis, Eucommia ulmoides, dodder seed, prepared rehmannia and cyperus rotundus, pass through a 50-mesh sieve, put into a sealed container, inject ethanol into the container and seal and soak for 15-30 days to obtain a mixture A, wherein the ethanol concentration is 75%, and the solid-liquid ratio of the raw materials to the ethanol is 1:3;

[0070] Step 3: extract the supernatant of mixture A to recover ethanol, and concentrate under reduced pressure to obtain a thick paste;.

[0071] Step 4: crushing Panax notoginseng, dried tangerine peel, wolfberry and fructus aurantii through a 250 sieve and mixing with calcium caseinate to obtain a mixture B;

[0072] Step 5: The thick paste mixture B is fully mixed and made into pills to obtain pills for treating bone and joint diseases.

[0073] Comparative Example 1:

[0074] The difference between Comparative Example 1 and Example 1 is that the formula includes 2 parts of Panax notoginseng, 3 parts of turmeric, 4 parts of Chinese angelica, 4 parts of Cyathula officinalis, 4 parts of safflower, and 4 parts of Impatiens balsamina.

[0075] Comparative Example 2:

[0076] The difference between Comparative Example 2 and Example 1 is that the formula includes 3 parts of papaya, 4 parts of cassia twig, 2 parts of mulberry twig and 3 parts of drynaria.

[0077] Comparative Example 3:

[0078] The difference between Comparative Example 3 and Example 1 is that the formula contains 3 parts of Epimedium, 3 parts of Morinda officinalis, 2 parts of Eucommia ulmoides and 3 parts of Cuscuta australis;

[0079] Comparative Example 4:

[0080] The difference between Comparative Example 4 and Example 1 is that the formula does not contain tangerine peel, dried ginger and angelica dahurica.

[0082] Test Example 1:

[0083] The safety test of the pills prepared in the above Examples 1-3 and Comparative Examples 1-4 was carried out, and an oral acute toxicity test was carried out using SD rats (refer to GB / T15193.3-2003), and the test rats were observed to see whether abnormal reactions occurred (such as ruffled hair, lethargy, pale or congested ears, exophthalmos, staggering, muscle paralysis, dyspnea, coma, convulsions, incontinence, etc.), whether there was death, and the cause of death was analyzed;

[0084] A 30-day feeding test (short-term oral toxicity test, subacute toxicity test, refer to GB / T23179-2008) was conducted to observe growth status, body weight and food utilization, hematological and blood biochemical indices, and pathological changes in the heart, liver, spleen, lung, kidney, stomach, intestine, etc. were observed by autopsy. The organ system values ​​of the liver, kidney, spleen, testicle (male) and ovary (female) were measured, and the organ system value (organ / body weight×100%) was calculated.

[0085] Test results: All the tested rats grew and developed well, and their behavior, mental state, coat color, eating, drinking, and urination were normal, revealing that the pills of each embodiment and comparative example had no adverse effects on the general condition of rats, had no adverse effects on the weight gain and growth and development of rats, had no adverse effects on food utilization, had no adverse effects on the basic indicators of hematology, had no adverse effects on the main indicators of blood biochemistry, and had no adverse effects on major organs.

[0086] It can be seen that the pills of the present application have no acute toxic side effects, and long-term feeding has no adverse effects on weight gain, food utilization, hematology, organs and other indicators, and can be consumed for a long time.

[0087] Test Example 2:

[0088] The pills prepared in the above Examples 1-3 and Comparative Examples 1-4 were subjected to efficacy tests. 210 rats with acute arthritis symptoms (manifested as lameness and redness and swelling around the joints) were selected and randomly divided into 7 groups, each with 30 rats. The rats were fed for 60 consecutive days (each rat was fed twice a day, 0.3 pills each time). The improvement of redness and swelling after 3, 7 and 14 days of feeding was observed, and the improvement of lameness after 30, 45 and 60 days of feeding was observed. The results are shown in Table 1:

[0089]

[0090] Table 3

[0091] It can be seen from the above table that the pills prepared in Examples 1-3 of the present application have significant therapeutic effects on symptoms such as swelling around joints and lameness caused by arthritis, and the pills prepared in Example 1 have the best effect;

[0092] Panax notoginseng, turmeric, angelica, Chinese rhubarb, safflower and Impatiens balsamina all have good blood circulation and blood stasis effects. By comparing Example 1 and Comparative Example 1, it can be seen that the efficacy of Comparative Example 1 in which the amount of such raw materials is reduced is significantly poor;

[0093] Papaya, cinnamon twig, mulberry twig and bone drynaria have the effects of removing dampness, relieving pain and dredging meridians. By comparing Example 1 and Comparative Example 2, it can be seen that the efficacy of Comparative Example 2 in which the formula amount of such raw materials is reduced is significantly poor;

[0094] Epimedium, Morinda officinalis, Eucommia ulmoides and Cuscuta australis have the effects of tonifying kidney yang and strengthening tendons and bones. By comparing Example 1 and Comparative Example 3, it can be seen that the efficacy of Comparative Example 3 in which the formula amount of such raw materials is reduced is significantly poor;

[0095] Tangerine peel, dried ginger and angelica dahurica have the effects of warming the interior, dispelling cold and drying dampness. The efficacy of Comparative Example 4 without adding these raw materials is also poor, but better than Comparative Examples 1-3.

[0096] Although the present invention has been described in detail with reference to the aforementioned embodiments, it is still possible for those skilled in the art to modify the technical solutions described in the aforementioned embodiments, or to make equivalent substitutions for some of the technical features therein. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the protection scope of the present invention.

Claims

1. A pill for treating bone and joint diseases, characterized in that: The formula of the pill is calculated by weight and includes 1-6 parts of Panax notoginseng, 6-15 parts of turmeric, 6-15 parts of angelica, 6-15 parts of cyperus rotundus, 6-15 parts of safflower, 6-15 parts of impatiens, 3-9 parts of papaya, 6-15 parts of cassia twig, 3-9 parts of mulberry twig, 3-9 parts of drynaria, 3-9 parts of tangerine peel, 3-9 parts of dried ginger, 1-6 parts of angelica dahurica, 3-9 parts of epimedium, 3-9 parts of Morinda officinalis, 3-9 parts of Eucommia ulmoides, 3-9 parts of Cuscuta australis, 6-15 parts of rehmannia root, 6-15 parts of wolfberry, 3-9 parts of fructus aurantii, 3-9 parts of cyperus rotundus, and 10-20 parts of calcium caseinate.

2. A pill for treating bone and joint diseases according to claim 1, characterized in that: The formula of the pill is calculated by weight and includes 2-5 parts of Panax notoginseng, 7-12 parts of turmeric, 7-12 parts of angelica, 7-12 parts of Achyranthes bidentata, 7-12 parts of safflower, 7-12 parts of Impatiens balsamina, 4-7 parts of papaya, 7-12 parts of cassia twig, 4-7 parts of mulberry twig, 4-7 parts of Drynaria fortunei, 4-7 parts of dried orange peel, 4-7 parts of dried ginger, 1-6 parts of Angelica dahurica, 4-7 parts of Epimedium, 4-7 parts of Morinda officinalis, 4-7 parts of Eucommia ulmoides, 4-7 parts of Cuscuta australis, 7-12 parts of Rehmannia glutinosa, 7-12 parts of Lycium barbarum, 4-7 parts of Fructus Aurantii Immaturus, 4-7 parts of Cyperus rotundus, and 10-20 parts of calcium caseinate.

3. A pill for treating bone and joint diseases according to claim 1, characterized in that: The formula of the pill is calculated by weight and includes 3 parts of Panax notoginseng, 9 parts of turmeric, 9 parts of Angelica sinensis, 9 parts of Achyranthes bidentata, 9 parts of safflower, 9 parts of Impatiens balsamina, 6 parts of papaya, 9 parts of cinnamon twig, 6 parts of mulberry twig, 6 parts of Drynaria fortunei, 6 parts of dried tangerine peel, 6 parts of dried ginger, 3 parts of Angelica dahurica, 6 parts of Epimedium, 6 parts of Morinda officinalis, 6 parts of Eucommia ulmoides, 6 parts of Cuscuta australis, 9 parts of Rehmannia glutinosa, 9 parts of Lycium barbarum, 6 parts of Fructus Aurantii Immaturus, 6 parts of Cyperus rotundus, and 12 parts of calcium caseinate.

4. A process for preparing a pill for treating bone and joint diseases, used for preparing the pill as claimed in any one of claims 1 to 3, characterized in that: The following steps are involved: Step 1: Weigh the raw materials in the formula, wash and dry the raw materials except calcium caseinate, and then prepare them for use; Step 2: Crush and sieve turmeric, Chinese angelica, Chinese rhizome, safflower, impatiens, papaya, cinnamon twig, mulberry twig, bone drynaria, dried ginger, angelica dahurica, epimedium, Morinda officinalis, Eucommia ulmoides, dodder seed, rehmannia glutinosa and cyperus rotundus, put them into a sealed container, inject ethanol into the container and seal it for 15-30 days to obtain a mixture A; Step 3: extract the supernatant of mixture A to recover ethanol, and concentrate under reduced pressure to obtain a thick paste;. Step 4: crush and sieve the Panax notoginseng, dried tangerine peel, wolfberry and fructus aurantii, and mix them with calcium caseinate to obtain a mixture B; Step 5: The thick paste mixture B is fully mixed and made into pills to obtain pills for treating bone and joint diseases.

5. The preparation process of a pill for treating bone and joint diseases according to claim 4, characterized in that: The Fructus Aurantii Immaturus is prepared by the method of frying with bran, stir-frying over medium heat, and fumigating with wheat bran to change the medicinal properties of the Fructus Aurantii Immaturus and mitigate its harsh nature. The weight ratio of the Fructus Aurantii Immaturus to wheat bran is 100:

15.

6. The preparation process of a pill for treating bone and joint diseases according to claim 4, characterized in that: Use salt water roasting method to prepare Eucommia ulmoides. Mix Eucommia ulmoides with salt water, wait until the salt water is absorbed, stir-fry over low heat until the white silk in the Eucommia ulmoides skin can be easily broken, then it is ready to be served. The weight ratio of Eucommia ulmoides to salt is 100:

2.

7. The preparation process of a pill for treating bone and joint diseases according to claim 4, characterized in that: The preparation method of dried ginger is: use high heat to heat river sand until it is fluid, then add dried ginger of different sizes, turn it over appropriately, until the dried ginger swells and a strong aroma exudes.

8. The preparation process of a pill for treating bone and joint diseases according to claim 4, characterized in that: Papaya is cooked using the wine roasting method. Mix the papaya slices and rice wine until the rice wine is absorbed. Stir-fry over low heat until dry and remove from the pan. The weight ratio of papaya to rice wine is 100:

20.

9. The preparation process of a pill for treating bone and joint diseases according to claim 4, characterized in that: In the step 2, the raw material needs to be sieved through a 50-80 mesh sieve after being crushed, the ethanol concentration is 75-90%, and the solid-liquid ratio of the raw material to the ethanol is 1:2-5.

10. The preparation process of a pill for treating bone and joint diseases according to claim 4, characterized in that: In the step 4, the raw material needs to be sieved through a 250 sieve after being crushed.

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