A high-precision detection device and detection method for vascular fluid mechanics

Abstract

The present invention discloses a high-precision detection device and detection method for vascular fluid mechanics, which belongs to the field of blood flow measurement technology. The high-precision detection device for vascular fluid mechanics includes a fixing mechanism, a clamping fixture is arranged above the fixing mechanism, the sample is fixed on the clamping fixture, and an adjustment mechanism is arranged below the fixing mechanism. The base of the adjustment mechanism is rotatably connected to the mounting seat, and two mutually perpendicular transmission plates are arranged on the mounting seat. The transmission plates are arc-shaped structures, and arc-shaped grooves for the support rods of the fixing mechanism to pass through are arranged along the length direction of the transmission plates. The support rods are inserted into the arc-shaped grooves of the two transmission plates, and a power structure for driving the transmission plates to rotate is arranged on the mounting seat. The high-precision detection device and detection method for vascular fluid mechanics described in the present invention can solve the problem of poor accuracy of intravascular fluid mechanics testing.

Description

Technical Field

[0001] The present invention relates to the technical field of blood flow measurement, and in particular to a high-precision detection device and method for blood vessel fluid mechanics. Background Art

[0002] Intravascular blood flow parameters are important indicators for evaluating the function of the blood circulation system and play a very important role in the treatment and prevention of cardiovascular and cerebrovascular diseases. The measurement of blood flow parameters includes invasive measurement methods and non-invasive measurement methods. Invasive measurement methods require invasive surgery to insert a catheter into the body for measurement, which causes trauma to the patient and poses a risk of infection. Non-invasive measurement methods directly observe the blood flow in the blood vessels through ultrasound, magnetic resonance imaging or computed tomography to obtain blood flow indicators. However, these non-invasive measurement methods take a long time to measure, and are affected by the human body environment and the calculation method, so the accuracy of the measured data is low.

[0003] The existing patent CN202220324472.2 discloses a high-speed camera 3D printed blood vessel fluid dynamics analysis instrument, including a 3D printed blood vessel, a liquid perfusion body, a pressure test body, a fluid holding tank, a water pump and a camera group, the input end and the output end of the water pump are respectively connected to the two ends of the 3D printed blood vessel, one end of the 3D printed blood vessel is provided with a feed hole, the fluid holding tank is connected to the liquid perfusion body, the liquid tank injection body can inject the liquid in the fluid holding tank into the 3D printed blood vessel through the feed hole, the pressure test body can enter the 3D printed blood vessel to test the pressure in the 3D printed blood vessel, and the camera group can shoot and record the movement trajectory of the liquid; this device can simulate the blood vessel pressure at the lesion position when the 3D printed blood vessel fluid moves, and simulate the real fluid dynamics changes in the 3D printed blood vessel. Since the direction of blood vessels in the human body is diverse, affected by gravity, blood flow resistance and blood flow pattern during blood flow, the direction of blood vessels has a relatively obvious effect on blood flow. When measuring and analyzing the fluid mechanics of 3D printed blood vessels, the above patent cannot simulate the direction of the blood vessels, affecting the accuracy of the intravascular fluid mechanics test. Summary of the invention

[0004] The purpose of the present invention is to provide a high-precision detection device and detection method for vascular fluid mechanics to solve the problem of poor accuracy of intravascular fluid mechanics testing.

[0005] To achieve the above-mentioned objectives, the present invention provides a high-precision detection device for vascular fluid mechanics, including a fixing mechanism, a locking structure for locking a clamping fixture is arranged above the fixing mechanism, the sample is fixed on the clamping fixture, and an adjustment mechanism for adjusting the angle of the sample is arranged below the fixing mechanism; the adjustment mechanism includes a base, a mounting seat is arranged above the base, the base is rotatably connected to the mounting seat, two transmission plates perpendicular to each other are arranged on the mounting seat, the transmission plate is an arc-shaped structure, and an arc-shaped groove for allowing a support rod of the fixing mechanism to pass through is arranged along the length direction of the transmission plate, the support rod is inserted into the arc-shaped grooves of the two transmission plates, and a power structure for driving the transmission plate to rotate is arranged on the mounting seat.

[0006] Preferably, a limiting sleeve is provided on the upper surface of the base, and a limiting block is provided on the lower surface of the mounting seat. The limiting block is located in the limiting sleeve and is rotatably connected to the limiting sleeve. A sleeve is provided on the limiting sleeve, and a top screw is connected to the inner thread of the sleeve. The top screw passes through the limiting sleeve and is tightened against the side of the limiting block. Anti-slip grooves are provided on the side of the limiting block.

[0007] Preferably, the power structure includes a rotating shaft, both ends of the transmission plate are arranged on the rotating shaft, the rotating shaft is rotatably connected to the support plate vertically arranged on the mounting seat, and a knob for driving the rotating shaft to rotate is arranged on the rotating shaft; a positioning structure for positioning the rotating shaft is arranged between the rotating shaft and the support plate; a supporting ball is arranged above the center of the mounting seat, the supporting ball is fixed on a rotating shaft, the supporting ball and the rotating shaft are arranged coaxially, a guide groove is arranged on the spherical surface of the supporting ball along the length direction of the rotating shaft, and an arc-shaped guide block is arranged at the bottom end of the support rod, the guide block is located in the guide groove and is slidably connected to the guide groove.

[0008] Preferably, the positioning structure includes a positioning plate, which is coaxially fixed on the rotating shaft, a locking plate is provided on the outside of the rotating shaft, a through hole is provided in the middle of the locking plate for allowing the rotating shaft to pass through, the rotating shaft and the locking plate are rotatably connected, anti-slip grooves are provided on the sides opposite to the locking plate and the positioning plate, a plurality of connecting rods are provided on the locking plate, and an arc-shaped sliding groove corresponding to the connecting rod for allowing the connecting rod to pass through is provided on the supporting plate, the connecting rod is slidably connected to the sliding groove, a rotating plate is provided on the outside of the supporting plate, the rotating plate is fixedly connected to the connecting rod, a fixed shaft is provided on the rotating plate for driving the rotating plate to rotate, a handle is provided on the fixed shaft, a first spring is provided between the rotating plate and the support plate to apply inward pulling force to the rotating plate; a positioning component for positioning the rotating plate is provided on the supporting plate.

[0009] Preferably, the positioning assembly includes a fixed sleeve, which is fixed on the supporting plate. The fixed sleeve is coaxially arranged with the rotating plate. A limiting groove arranged along the axial direction of the fixed sleeve and a rotating groove arranged along the circumference of the fixed sleeve are arranged on the side wall of the fixed sleeve. The limiting groove is connected end to end with the rotating groove. A fixing pin is arranged on the rotating plate. The fixing pin is located in the limiting groove and slides along the limiting groove and the rotating groove.

[0010] Preferably, the locking structure includes a locking pin, a first sliding hole is provided on the fixed seat for allowing the locking pin to slide up and down, the support rod is fixed to the center of the lower surface of the fixed seat, and a lifting assembly is provided on the fixed seat to drive the locking pin to lift and lower; a second sliding hole corresponding to the locking pin is provided on the connecting plate of the clamping tool, a third mounting groove is provided on the side wall of the second sliding hole, a sliding block is slidably provided in the third mounting groove, a locking pin is provided at one end of the sliding block close to the second sliding hole, a locking hole is provided on the locking pin for inserting the locking pin, a fifth spring is provided between the sliding block and the third mounting groove for inserting the locking pin into the locking hole, a transmission hole is provided on the sliding block, a transmission block is provided in the transmission hole, the inclined surface of the bottom end of the transmission block contacts the inclined surface of the transmission hole, the transmission block is slidably connected to the connecting plate, a pressure plate is provided on the top of the transmission block, and a fourth spring is provided between the pressure plate and the connecting plate.

[0011] Preferably, the lifting assembly includes a rotating plate, the middle part of the rotating plate is rotatably connected to the second mounting groove through a central axis, the second mounting groove is arranged on the side wall of the card slot, the card slot is located at the center of the fixed seat, a first mounting groove is arranged above the card slot, and a clamping platform arranged on the lower surface of the connecting plate is inserted in the first mounting groove; a protrusion is slidably arranged in the card slot, a groove is arranged on the lower surface of the protrusion, a second spring for applying an upward thrust to the protrusion is arranged between the groove and the card slot, a first transmission groove corresponding to the rotating plate is arranged on the side wall of the protrusion, a sliding ball arranged at one end of the rotating plate is slidably located in the first transmission groove, and a sliding ball arranged at the other end of the rotating plate is slidably located in the second transmission groove, the second transmission groove is arranged on the lifting block, a locking pin is arranged on the upper surface of the lifting block, and a third spring for applying a downward thrust to the lifting block is arranged between the lifting block and the second mounting groove.

[0012] Preferably, a testing mechanism for testing the fixing mechanism is provided on one side of the fixing mechanism, the testing mechanism includes a nuclear magnetic resonance detector, a protective shell is provided on the outside of the nuclear magnetic resonance detector, a workbench is provided on one side of the protective shell, the base is placed on the workbench, a guide rail for guiding the sliding of the base is provided on the workbench, a power element for driving the base to slide horizontally along the guide rail is provided inside the protective shell, a mounting plate is provided inside the protective shell, an intermediate guide rail for guiding the sliding of the base is provided on the mounting plate, a protective door is provided on the side of the protective shell close to the base, and a door closing structure for closing the protective door is provided on the mounting plate; the door closing structure includes a transmission gear The transmission gear is rotatably connected to the mounting plate, a rack meshing with the transmission gear is arranged on the base, a first gear is arranged on the wheel axle of the transmission gear, the first gear meshes with the second gear rotatably arranged on the mounting plate, an intermediate gear is arranged on the wheel axle of the second gear, the intermediate gear meshes with the first rack and the second rack, the first rack and the second rack are respectively arranged at the bottom ends of the two protective doors, the first rack and the second rack are respectively located on both sides of the intermediate gear, a guide hole with a guiding effect on the sliding of the protective door is arranged on the mounting plate, the connecting block arranged on the protective door is located in the guide hole and slides along the guide hole, and the first rack and the second rack are respectively arranged on the connecting blocks on the two protective doors.

[0013] Preferably, a clamping table is provided above the connecting plate, and the sample is fixed on the clamping table. One end of the sample is connected to the liquid outlet of the circulation pump through a tee and a connecting pipe, and pressure sensors for detecting the pressure of the test fluid in the sample are provided at both ends of the sample. The other end of the sample is connected to the liquid inlet of the circulation pump through a connecting pipe, and a liquid inlet pipe is provided on the tee, and a control valve is provided on the liquid inlet pipe.

[0014] A detection method, based on the above-mentioned high-precision detection device for vascular fluid mechanics, comprises the following steps:

[0015] S1. Place the connecting plate on the fixing seat, insert the mounting block into the first mounting groove, apply downward pressure to the protrusion, and the protrusion slides downward along the card slot, the protrusion drives one end of the rotating plate to rotate, and the other end of the rotating plate drives the lifting block to move upward, the lifting block drives the locking pin to move upward, the locking pin is inserted into the second sliding hole, and the card pin is inserted into the card hole of the locking pin under the action of the second spring, so as to realize the locking of the connecting plate on the fixing seat;

[0016] S2. Fix the sample on the clamping table; pull the fixed shaft outward through the handle, and the fixed shaft drives the locking plate to slide outward through the rotating plate and the connecting rod, the locking plate is separated from the positioning plate, the fixing pin slides along the limit groove, the rotating plate is rotated, the connecting rod slides in the slide groove, the fixing pin slides along the rotating groove, and under the action of the first spring, the fixing pin is clamped in the rotating groove to fix the locking plate; rotate the transmission plate through the knob and the rotating shaft, and the transmission plate drives the fixing seat to rotate through the support rod to adjust the position of the sample;

[0017] S3, the rotating plate is rotated in the opposite direction. Under the action of the first spring, the locking plate contacts the positioning plate, and the fixing pin cannot rotate in the limiting groove, thereby locking and positioning the rotating shaft; the angle adjustment of the sample is completed;

[0018] S4. Connect the circulation pump to both ends of the sample through the connecting pipe, connect the connecting pipe to the liquid inlet end of the sample through the tee, open the control valve, inject the test fluid into the sample through the tee, and close the control valve; turn on the circulation pump, the circulation pump drives the test fluid in the sample to flow, and detect the pressure of the test fluid in the sample through the pressure sensor. After the pressure stabilizes, perform the test;

[0019] S5. The base is driven by a power element to slide along the guide rail on the workbench, and the base enters the protective shell through the middle guide rail. As the base slides, the transmission rack on the base meshes with the transmission gear, driving the transmission gear to rotate. The transmission gear drives the middle gear to rotate through the first gear and the second gear. The middle gear drives the first rack and the second rack to slide relative to each other, thereby driving the two protective doors to slide relative to each other. After the base completely slides into the protective shell, the protective door is closed, and the sample is tested by a nuclear magnetic resonance detector.

[0020] The advantages and positive effects of the high-precision vascular fluid mechanics detection device and detection method described in the present invention are:

[0021] 1. An adjustment mechanism is arranged below the fixing mechanism, and the adjustment mechanism adjusts the angle of the fixing seat through two transmission plates to simulate the real state of the blood vessel and improve the accuracy of the intravascular fluid mechanics test.

[0022] 2. When the locking plate is pulled outward, the locking plate is separated from the positioning plate, and the fixing pin slides into the rotating groove along the limiting groove to fix the locking plate, so as to facilitate the rotation of the shaft and adjust the direction of the sample. When the locking plate is rotated in the opposite direction, the locking plate slides into the limiting groove along the rotating groove, and the limiting groove limits the fixing pin. The rotating plate cannot rotate under the action of the fixing pin, so that the rotating shaft is locked by the locking plate and the positioning plate, thereby improving the stability of the rotating shaft locking. The rotation operation of the shaft is very convenient.

[0023] 3. The clamping fixture is locked and connected with the fixing mechanism through the locking structure. Press the connecting plate downward, the protrusion drives one end of the rotating plate to rotate, the other end of the rotating plate drives the lifting block to move upward, the lifting block drives the locking pin to move upward, the locking pin is inserted into the second sliding hole, and the bayonet pin is inserted into the bayonet hole of the locking pin under the action of the second spring to achieve the locking of the connecting plate on the fixing seat. Press the pressing plate downward, the pressing plate pushes the slider to slide through the transmission block, thereby separating the connecting plate from the fixing seat. The fixing mechanism and the clamping fixture are easy to install and disassemble, and it is convenient to replace the clamping fixture.

[0024] 4. A protective shell is provided on the test mechanism, and a protective door is provided on the protective shell. During the test, the radiation is shielded to reduce the mutual influence of the radiation inside and outside the protective shell. The protective door is automatically closed when the base slides into the protective shell; it is automatically opened when the base slides out, which is convenient to use.

[0025] The technical solution of the present invention is further described in detail below through the accompanying drawings and embodiments. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a schematic diagram of the three-dimensional structure of Example 1 of the present invention;

[0027] Figure 2 It is a schematic diagram of the cross-sectional structure of Example 1 of the present invention;

[0028] Figure 3 for Figure 2 Middle A: Enlarged view;

[0029] Figure 4 It is a schematic diagram of the three-dimensional structure of the fixing sleeve according to Embodiment 1 of the present invention;

[0030] Figure 5 It is a schematic diagram of the three-dimensional structure of the fixing mechanism of Example 2 of the present invention;

[0031] Figure 6 This is a schematic diagram of the cross-sectional structure of the fixing mechanism of Example 2 of the present invention;

[0032] Figure 7 This is a schematic diagram of the three-dimensional structure of the clamping tooling according to Embodiment 2 of the present invention;

[0033] Figure 8 This is a schematic diagram of the cross-sectional structure of the clamping tooling according to Embodiment 2 of the present invention;

[0034] Fig. 9 This is a schematic diagram of the three-dimensional structure of the testing mechanism of Example 3 of the present invention;

[0035] Fig.10 This is a schematic diagram of the three-dimensional structure of the protective shell of Example 3 of the present invention;

[0036] Fig.11 This is a schematic diagram of the door closing structure of Example 3 of the present invention;

[0037] Fig.12 This is a front view structural diagram of a door closing structure according to Embodiment 3 of the present invention;

[0038] Fig.13 This is a schematic diagram of the test connection of the sample of the present invention.

[0039] Reference numerals

[0040] 1. Adjustment mechanism; 11. Base; 12. Limit sleeve; 13. Mounting seat; 14. Limit block; 15. Top screw; 16. Support plate; 17. Transmission plate; 18. Rotating shaft; 19. Knob; 110. Positioning plate; 111. Locking plate; 112. Connecting rod; 113. Slide groove; 114. Rotating plate; 115. Fixed shaft; 116. Handle; 117. Fixed sleeve; 118. First spring; 119. Limit groove; 120. Rotating groove; 121. Support ball; 122. Guide groove; 123. Transmission rack;

[0041] 2. Fixing mechanism; 21. Fixing seat; 22. Support rod; 23. Guide block; 24. First mounting groove; 25. Clamping groove; 26. Protrusion; 27. Groove; 28. Second spring; 29. ​​First transmission groove; 210. Second mounting groove; 211. Rotating plate; 212. Central axis; 213. Lifting block; 214. Locking pin; 215. Third spring; 216. First sliding hole; 217. Second transmission groove;

[0042] 3. Clamping tool; 31. Clamping platform; 32. Connecting plate; 33. Mounting block; 34. Second sliding hole; 35. Pressing plate; 36. Fourth spring; 37. Transmission block; 38. Sliding block; 39. Bayonet; 310. Fifth spring; 311. Third mounting slot; 312. Transmission hole;

[0043] 4. Testing mechanism; 41. Protective shell; 42. Protective door; 43. Workbench; 44. Guide rail; 45. Mounting plate; 46. Transmission gear; 47. First gear; 48. Second gear; 49. Intermediate gear; 410. First rack; 411. Second rack; 412. Guide hole; 413. Connecting block;

[0044] 5. Test sample; 6. Tee pipe; 7. Circulation pump; 8. Connecting pipe; 9. Control valve. DETAILED DESCRIPTION

[0045] In the description of the present invention, it should be noted that the terms "upper", "lower", "inside", "outside", etc. indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings, or the positions or positional relationships in which the invented product is usually placed when in use. They are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as a limitation on the present invention. In the description of the present invention, it should also be noted that, unless otherwise clearly specified and limited, the terms "setting", "installation", and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be a connection between the two elements. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0046] The embodiments of the present invention are described in detail below in conjunction with the accompanying drawings.

[0047] Example 1

[0048] like Figure 1 , Figure 2 A high-precision detection device for vascular fluid mechanics includes a fixing mechanism 2, which is used to support a sample. A clamping tool 3 is arranged above the fixing mechanism 2, and the clamping tool 3 is used to fix a sample 5. An adjustment mechanism 1 for adjusting the angle of the sample is arranged below the fixing mechanism 2.

[0049] The adjustment mechanism 1 includes a base 11, and a mounting seat 13 is arranged above the base 11. A limiting sleeve 12 is fixedly arranged on the upper surface of the base 11, and a limiting block 14 is fixedly arranged on the lower surface of the mounting seat 13. The limiting block 14 is located in the limiting sleeve 12 and is rotatably connected to the limiting sleeve 12 through a bearing. A sleeve is fixedly arranged on the limiting sleeve 12, and a top screw 15 is connected to the inner thread of the sleeve. The top screw 15 passes through the limiting sleeve 12 and is tightened on the side of the limiting block 14. Anti-slip grooves are arranged on the side of the limiting block 14 to improve the stability of the locking of the mounting seat 13 by the top screw 15. The mounting seat 13 can be rotated by loosening the top screw 15, so as to adjust the direction of the mounting seat 13 as needed.

[0050] Two mutually perpendicular transmission plates 17 are arranged on the mounting seat 13, and the transmission plates 17 are semicircular arc structures. An arc groove is arranged along the length direction of the transmission plates 17 for the support rod 22 of the fixing mechanism 2 to pass through, and the support rod 22 is inserted into the arc grooves of the two transmission plates 17, and the support rod 22 slides along the arc groove. The support rod 22 is located at the intersection formed by the two arc grooves, and the two transmission plates 17 drive the support rod 22 to rotate through the arc groove. The two transmission plates 17 are arranged concentrically, and the support rod 22 rotates around the center of the circle of the transmission plates 17.

[0051] The mounting seat 13 is provided with a power structure for driving the transmission plate 17 to rotate. The power structure includes a rotating shaft 18, and both ends of the transmission plate 17 are fixedly arranged on the rotating shaft 18. The rotating shaft 18 is rotatably connected to the support plate 16 vertically fixedly arranged on the mounting seat 13 through a bearing. A knob 19 for driving the rotating shaft 18 to rotate is fixedly arranged on the rotating shaft 18. A supporting ball 121 is arranged above the center of the mounting seat 13, and the supporting ball 121 is fixedly arranged on a rotating shaft 18. The supporting ball 121 is arranged coaxially with the rotating shaft 18. A guide groove 122 is arranged on the spherical surface of the supporting ball 121 along the length direction of the rotating shaft 18 where it is located, and the guide groove 122 is arranged in accordance with the spherical surface of the supporting ball 121. An arc-shaped guide block 23 is fixedly arranged at the bottom end of the support rod 22, and the guide block 23 is located in the guide groove 122 and is slidably connected to the guide groove 122. The guide groove 122 is provided with grooves 27 on both sides, and the guide block 23 is provided with a boss matched with the groove 27, the boss is located in the groove 27 and is slidably connected with the groove 27. The arrangement of the boss and the groove 27 improves the stability of the support rod 22 in rotation.

[0052] like Figure 3 As shown. A positioning structure for positioning the rotating shaft 18 is provided between the rotating shaft 18 and the supporting plate 16. The positioning structure includes a positioning plate 110, and the positioning plate 110 is coaxially fixed on the rotating shaft 18. A locking plate 111 is provided on the outside of the rotating shaft 18, and a through hole is provided in the middle of the locking plate 111 for the rotating shaft 18 to pass through, and the rotating shaft 18 is rotatably connected with the locking plate 111. Anti-slip grooves are provided on the side of the locking plate 111 opposite to the positioning plate 110 to improve the locking stability when the locking plate 111 contacts the positioning plate 110. A plurality of connecting rods 112 are fixedly provided on the locking plate 111, and an arc-shaped slide groove 113 corresponding to the connecting rod 112 is provided on the supporting plate 16 for the connecting rod 112 to pass through, and the connecting rod 112 is slidably connected with the slide groove 113. A rotating plate 114 is provided on the outside of the supporting plate 16, and the rotating plate 114 is fixedly connected with the connecting rod 112. The rotating plate 114 is fixedly provided with a fixed shaft 115 for driving the rotating plate 114 to rotate, and the fixed shaft 115 is fixedly provided with a handle 116, and the rotating plate 114 is driven to rotate by the handle 116 and the fixed shaft 115. A first spring 118 is provided between the rotating plate and the supporting plate 16 to apply an inward pulling force to the rotating plate 114, and the first spring 118 improves the locking stability of the locking plate 111 and the positioning plate 110, and improves the locking stability of the rotating shaft 18.

[0053] like Figure 4As shown. A positioning assembly for positioning the rotating plate 114 is provided on the support plate 16. The positioning assembly includes a fixing sleeve 117, and the fixing sleeve 117 is fixed on the support plate 16. The fixing sleeve 117 is coaxially arranged with the rotating plate 114. A limiting groove 119 arranged along the axial direction of the fixing sleeve 117 and a rotating groove 120 arranged along the circumferential direction of the fixing sleeve 117 are provided on the side wall of the fixing sleeve 117, and the limiting groove 119 is connected to the rotating groove 120 end to end. A fixing pin is fixedly provided on the rotating plate 114, and the fixing pin is located in the limiting groove 119 and slides along the limiting groove 119 and the rotating groove 120.

[0054] When the locking plate 111 is pulled outward, the locking plate 111 is separated from the positioning plate 110, and the fixing pin slides into the rotation groove 120 along the limiting groove 119 to fix the locking plate 111, thereby facilitating the rotation of the rotating shaft 18 to adjust the direction of the sample. When the locking plate 111 is rotated in the opposite direction, the locking plate 111 slides into the limiting groove 119 along the rotation groove 120, and the limiting groove 119 limits the fixing pin, and the rotating plate 114 cannot rotate under the action of the fixing pin, thereby locking the rotating shaft 18 through the locking plate 111 and the positioning plate 110, thereby improving the locking stability of the rotating shaft 18. The rotation operation of the rotating shaft 18 is very convenient.

[0055] Example 2

[0056] This embodiment is provided with a locking structure on the basis of the embodiment 1, and the clamping tool 3 is locked and connected with the fixing mechanism 2 through the locking structure.

[0057] like Figure 5 , Figure 6 The locking structure includes a locking pin 214, and a first sliding hole 216 is provided on the fixed seat 21 to enable the locking pin 214 to slide up and down. The support rod 22 is fixed at the center of the lower surface of the fixed seat 21. The fixed seat 21 is provided with a lifting component to drive the locking pin 214 to move up and down.

[0058] The lifting assembly includes a rotating plate 211, and the middle part of the rotating plate 211 is rotatably connected to the second mounting groove 210 through a central axis 212. The second mounting groove 210 is arranged on the side wall opposite to the card slot 25, and the card slot 25 is located at the center of the fixed seat 21. A first mounting groove 24 is arranged above the card slot 25, and a clamping platform 31 fixedly arranged on the lower surface of the connecting plate 32 is inserted into the first mounting groove 24. The first mounting groove 24 is a rectangular groove, and the positioning and installation of the connecting plate 32 is achieved by the first mounting groove 24 and the clamping platform 31. A protrusion 26 is slidably arranged in the card slot 25, and the protrusion 26 slides up and down along the card slot 25. A groove 27 is arranged on the lower surface of the protrusion 26, and a second spring 28 is arranged between the groove 27 and the card slot 25 to apply an upward thrust to the protrusion 26, and the two ends of the second spring 28 are respectively fixedly connected to the groove 27 and the card slot 25.

[0059] A first transmission groove 29 corresponding to the rotating plate 211 is provided on the side wall of the protrusion 26, and a sliding ball fixedly provided at one end of the rotating plate 211 slides in the first transmission groove 29. A sliding ball fixedly provided at the other end of the rotating plate 211 slides in the second transmission groove 217, and the second transmission groove 217 is provided on the lifting block 213. The locking pin 214 is fixedly provided on the upper surface of the lifting block 213. A third spring 215 for applying a downward thrust to the lifting block 213 is provided between the lifting block 213 and the second mounting groove 210, and the third spring 215 is sleeved on the outside of the locking pin 214. The locking pin 214 is inserted into the inside of the first sliding hole 216 under the action of the third spring 215, so as to protect the locking pin 214.

[0060] like Figure 7 , Figure 8 As shown. The connecting plate 32 of the clamping fixture 3 is provided with a second sliding hole 34 corresponding to the locking pin 214. The side wall of the second sliding hole 34 is provided with a third mounting groove 311, and a slider 38 is slidably provided in the third mounting groove 311. A latch pin 39 is fixedly provided at one end of the slider 38 close to the second sliding hole 34, and a latch hole for inserting the latch pin 39 is provided on the locking pin 214. A fifth spring 310 is provided between the slider 38 and the third mounting groove 311 to insert the latch pin 39 into the latch hole, and the locking between the connecting plate 32 and the fixing seat 21 is achieved through the latch pin 39 and the latch hole.

[0061] The slider 38 is provided with a transmission hole 312, and a transmission block 37 is provided in the transmission hole 312. The inclined surface at the bottom end of the transmission block 37 contacts the inclined surface of the transmission hole 312. The transmission block 37 is slidably connected with the connecting plate 32. A pressing plate 35 is fixedly provided at the top of the transmission block 37. A fourth spring 36 is provided between the pressing plate 35 and the connecting plate 32. By pressing the transmission block 37 downward with the pressing plate 35, the transmission block 37 pushes the slider 38 outward through the inclined surface, and the slider 38 drives the latch 39 to slide out of the latch hole. The locking pin 214 is reset under the action of the third spring 215 and the second spring 28, so as to facilitate the separation of the connecting plate 32 from the fixing seat 21.

[0062] Example 3

[0063] This embodiment adds a testing mechanism 4 on the basis of Embodiment 2, and the testing mechanism 4 is arranged on one side of the fixing mechanism 2.

[0064] like Fig. 9 , Fig.10As shown. The testing mechanism 4 includes a nuclear magnetic resonance detector, and the nuclear magnetic resonance detector adopts an existing model as needed. The velocity diagram and fluid dynamic image of the fluid flow are obtained by the nuclear magnetic resonance detector, and the flow state of the fluid in the sample 5 is analyzed. A protective shell 41 is provided on the outside of the nuclear magnetic resonance detector, and the protective shell 41 is made of magnetic shielding material to reduce the influence of external radiation on the nuclear magnetic resonance detector, or the influence of the nuclear magnetic resonance detector on the external radiation. A workbench 43 is provided on one side of the protective shell 41, and the base 11 is placed on the workbench 43. A guide rail 44 that guides the sliding of the base 11 is provided on the workbench 43, and the base 11 slides into the protective shell 41 along the guide rail 44. A power element that drives the base 11 to slide horizontally along the guide rail 44 is provided inside the protective shell 41. The power element is an existing cylinder, electric cylinder, transmission belt or screw nut substructure, as long as it can drive the base 11 to slide into the protective shell 41. A mounting plate 45 is fixedly provided inside the protective shell 41 , and a middle guide rail 44 is provided on the mounting plate 45 to guide the sliding of the base 11 . The base 11 slides into the nuclear magnetic resonance detector through the middle guide rail 44 , so as to detect the sample.

[0065] like Fig.11 , Fig.12 As shown. A protective door 42 is provided on one side of the protective shell 41 close to the base 11, and a door closing structure for closing the protective door 42 is provided on the mounting plate 45. The door closing structure includes a transmission gear 46, and the transmission gear 46 is rotatably connected to the mounting plate 45 through a bearing. A rack meshing with the transmission gear 46 is fixedly provided on the base 11, and the rack is provided at one end of the base 11 away from the protective door 42, so that the protective door 42 slides again after the base 11 is about to enter the protective shell 41. The rack can be provided protruding from the base 11 to ensure that the base 11 smoothly enters the interior of the protective shell 41. A first gear 47 is fixedly provided on the axle of the transmission gear 46, and the first gear 47 is meshed with a second gear 48 rotatably provided on the mounting plate 45. An intermediate gear 49 is fixedly provided on the axle of the second gear 48. The wheel diameter of the first gear 47 is larger than the wheel diameters of the second gear 48 and the transmission gear 46, and the wheel diameter of the intermediate gear 49 is larger than the wheel diameter of the second gear 48, so as to realize the accelerated rotation of the intermediate gear 49.

[0066] The intermediate gear 49 is meshed with the first rack 410 and the second rack 411. The first rack 410 and the second rack 411 are respectively located on both sides of the intermediate gear 49 and are respectively fixedly arranged at the bottom ends of the two protective doors 42. A guide hole 412 is arranged on the mounting plate 45 to guide the sliding of the protective door 42. The connecting block 413 fixedly arranged on the protective door 42 is located in the guide hole 412 and slides along the guide hole 412. The first rack 410 and the second rack 411 are respectively arranged on the connecting blocks 413 on the two protective doors 42. The intermediate gear 49 drives the first rack 410 and the second rack 411 to slide relative to or away from each other, thereby realizing the relative or away sliding of the two protective doors 42. The protective shell 41 is closed by the protective door 42 to reduce the mutual influence of the radiation inside and outside the protective shell 41. A torsion spring is arranged between the transmission gear 46 and the mounting plate 45, so that the protective door 42 is in a normally open state.

[0067] like Fig.13 As shown, a clamping platform 31 is fixedly arranged above the connecting plate 32, and the sample 5 is fixed on the clamping platform 31. One end of the sample 5 is connected to the liquid outlet of the circulation pump 7 through the three-way pipe 6 and the connecting pipe 8, and the other end of the sample 5 is connected to the liquid inlet of the circulation pump 7 through the connecting pipe 8. Pressure sensors are arranged at both ends of the sample 5. The pressure sensors can be arranged at the connection between the sample 5 and the three-way pipe 6 or the connecting pipe 8, and are used to measure the fluid pressure when the fluid enters the sample 5 or flows out of the sample 5. Multiple pressure sensors, velocity sensors and flow meters can also be arranged inside the sample 5 as needed to measure the fluid pressure, fluid velocity and fluid flow at different positions inside the sample 5. A liquid inlet pipe is arranged on the three-way pipe 6, and a control valve 9 is arranged on the liquid inlet pipe. The required fluid is injected into the sample 5 through the liquid inlet pipe. The circulation pump 7 drives the fluid in the sample 5 to circulate, and pumps pulse fluid into the sample 5 to simulate blood flow. The circulation pump 7 can be fixed on the connecting plate 32 or the fixing seat 21. The circulation pump 7 is a non-ferromagnetic circulation pump 7 to avoid affecting the operation of the nuclear magnetic resonance device. The circulation pump 7 is a programmable circulation pump that can provide different flow rates for the fluid in the sample 5.

[0068] In the present invention, the parts in the protective shell 41 are all made of non-ferromagnetic materials, and the entire detection device is also made of non-ferromagnetic materials to avoid affecting the nuclear magnetic resonance detection and ensure the accuracy of the detection. The detection device meets the use requirements of magnetic resonance within 7T.

[0069] The detection method based on the above-mentioned high-precision detection device for vascular fluid mechanics includes the following steps:

[0070] S1. Place the connecting plate 32 on the fixing seat 21, insert the mounting block 33 into the first mounting groove 24, apply downward pressure to the protrusion 26, the protrusion 26 slides downward along the slot 25, the protrusion 26 drives one end of the rotating plate 211 to rotate, the other end of the rotating plate 211 drives the lifting block 213 to move upward, the lifting block 213 drives the locking pin 214 to move upward, the locking pin 214 is inserted into the second sliding hole 34, the locking pin 39 is inserted into the locking hole of the locking pin 214 under the action of the second spring 28, so as to realize the locking of the connecting plate 32 on the fixing seat 21.

[0071] S2. Fix the sample on the clamping table 31. Pull the fixed shaft 115 outwards through the handle 116, and the fixed shaft 115 drives the locking plate 111 to slide outwards through the rotating plate 114 and the connecting rod 112. The locking plate 111 is separated from the positioning plate 110, and the fixed pin slides along the limiting groove 119. The rotating plate 114 is rotated, and the connecting rod 112 slides in the sliding groove 113. The fixed pin slides along the rotating groove 120. Under the action of the first spring 118, the fixed pin is clamped in the rotating groove 120 to fix the locking plate 111; the transmission plate 17 is rotated through the knob 19 and the rotating shaft 18, and the transmission plate 17 drives the fixed seat 21 to rotate through the support rod 22 to adjust the position of the sample.

[0072] S3, the rotating plate 114 is rotated in the reverse direction. Under the action of the first spring 118, the locking plate 111 contacts the positioning plate 110, and the fixing pin cannot rotate in the limiting groove 119, thereby locking and positioning the rotating shaft 18; the angle adjustment of the sample is completed.

[0073] S4. Connect the circulation pump 7 to both ends of the sample 5 through the connecting pipe 8, and the connecting pipe 8 is connected to the liquid inlet end of the sample 5 through the three-way pipe 6. Open the control valve 9, inject the required amount of test fluid into the sample 5 through the three-way pipe 6, and close the control valve 9. Turn on the circulation pump 7, and the circulation pump 7 drives the test fluid in the sample 5 to flow. The pressure of the test fluid in the sample 5 is detected by the pressure sensor, and the test is performed after reaching the required pressure and stabilizing.

[0074] S5. The power element drives the base 11 to slide along the guide rail 44 on the workbench 43, and the base 11 enters the protective shell 41 through the middle guide rail 44. As the base 11 slides, the transmission rack 123 on the base 11 engages with the transmission gear 46, driving the transmission gear 46 to rotate. The transmission gear 46 drives the middle gear 49 to rotate through the first gear 47 and the second gear 48. The middle gear 49 drives the first rack 410 and the second rack 411 to slide relative to each other, thereby driving the two protective doors 42 to slide relative to each other. After the base 11 completely slides into the protective shell 41, the protective door 42 is closed, and the sample 5 is tested by the nuclear magnetic resonance detector.

[0075] Therefore, the problem of poor accuracy of intravascular fluid dynamics testing can be solved by using the high-precision detection device and detection method for intravascular fluid dynamics described in the present invention.

[0076] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that they can still modify or replace the technical solution of the present invention with equivalents, and these modifications or equivalent replacements cannot cause the modified technical solution to deviate from the spirit and scope of the technical solution of the present invention.

Claims

1. A high-precision detection device for vascular fluid mechanics, characterized in that: It comprises a fixing mechanism, a locking structure for locking the clamping fixture is arranged above the fixing mechanism, the sample is fixed on the clamping fixture, and an adjusting mechanism for adjusting the angle of the sample is arranged below the fixing mechanism; the adjusting mechanism comprises a base, a mounting seat is arranged above the base, the base is rotatably connected with the mounting seat, two mutually perpendicular transmission plates are arranged on the mounting seat, the transmission plate is an arc structure, an arc groove for allowing the support rod of the fixing mechanism to pass through is arranged along the length direction of the transmission plate, the support rod is inserted into the arc grooves of the two transmission plates, and a power structure for driving the transmission plate to rotate is arranged on the mounting seat; The power structure includes a rotating shaft, both ends of the transmission plate are arranged on the rotating shaft, the rotating shaft is rotatably connected with a support plate vertically arranged on the mounting seat, and a knob is arranged on the rotating shaft to drive the rotating shaft to rotate; a positioning structure for positioning the rotating shaft is arranged between the rotating shaft and the support plate; a supporting ball is arranged above the center of the mounting seat, the supporting ball is fixedly arranged on a rotating shaft, the supporting ball and the rotating shaft are arranged coaxially, a guide groove is arranged on the spherical surface of the supporting ball along the length direction of the rotating shaft where the supporting ball is located, and an arc-shaped guide block is arranged at the bottom end of the support rod, and the guide block is located in the guide groove and is slidably connected to the guide groove; The positioning structure includes a positioning plate, which is coaxially fixed on the rotating shaft, a locking plate is arranged on the outside of the rotating shaft, a through hole is arranged in the middle of the locking plate for the rotating shaft to pass through, the rotating shaft and the locking plate are rotatably connected, anti-slip grooves are arranged on the sides opposite to the locking plate and the positioning plate, a plurality of connecting rods are arranged on the locking plate, an arc-shaped sliding groove corresponding to the connecting rods for the connecting rods to pass through is arranged on the supporting plate, the connecting rods are slidably connected to the sliding groove, a rotating plate is arranged on the outside of the supporting plate, the rotating plate is fixedly connected to the connecting rod, a fixed shaft for driving the rotating plate to rotate is arranged on the rotating plate, a handle is arranged on the fixed shaft, a first spring for applying inward pulling force to the rotating plate is arranged between the rotating plate and the supporting plate; a positioning component for positioning the rotating plate is arranged on the supporting plate.

2. A high-precision vascular fluid dynamics detection device according to claim 1, characterized in that: A limiting sleeve is provided on the upper surface of the base, and a limiting block is provided on the lower surface of the mounting seat. The limiting block is located in the limiting sleeve and is rotatably connected to the limiting sleeve. A sleeve is provided on the limiting sleeve, and a top screw is connected to the inner thread of the sleeve. The top screw passes through the limiting sleeve and is tightened against the side of the limiting block. Anti-slip grooves are provided on the side of the limiting block.

3. A high-precision vascular fluid dynamics detection device according to claim 2, characterized in that: The positioning assembly includes a fixed sleeve, which is fixed on the supporting plate. The fixed sleeve is coaxially arranged with the rotating plate. A limiting groove arranged along the axial direction of the fixed sleeve and a rotating groove arranged along the circumference of the fixed sleeve are arranged on the side wall of the fixed sleeve. The limiting groove is connected to the rotating groove end to end. A fixing pin is arranged on the rotating plate. The fixing pin is located in the limiting groove and slides along the limiting groove and the rotating groove.

4. A high-precision vascular fluid dynamics detection device according to claim 3, characterized in that: The locking structure includes a locking pin, a first sliding hole is provided on the fixed seat for allowing the locking pin to slide up and down, the support rod is fixed to the center of the lower surface of the fixed seat, and a lifting component is provided on the fixed seat to drive the locking pin to lift and lower; a second sliding hole corresponding to the locking pin is provided on the connecting plate of the clamping tool, a third mounting groove is provided on the side wall of the second sliding hole, a sliding block is slidably provided in the third mounting groove, a bayonet is provided at one end of the sliding block close to the second sliding hole, a bayonet is provided on the locking pin for inserting the bayonet, a fifth spring is provided between the sliding block and the third mounting groove for inserting the bayonet into the bayonet hole, a transmission hole is provided on the sliding block, a transmission block is provided in the transmission hole, the inclined surface of the bottom end of the transmission block contacts the inclined surface of the transmission hole, the transmission block is slidably connected with the connecting plate, a pressure plate is provided on the top of the transmission block, and a fourth spring is provided between the pressure plate and the connecting plate.

5. A high-precision vascular fluid dynamics detection device according to claim 4, characterized in that: The lifting assembly includes a rotating plate, the middle part of the rotating plate is rotatably connected to the second mounting groove through a central axis, the second mounting groove is arranged on the side wall of the card slot, the card slot is located at the center of the fixed seat, a first mounting groove is arranged above the card slot, and a clamping platform arranged on the lower surface of the connecting plate is inserted in the first mounting groove; a protrusion is slidably arranged in the card slot, a groove is arranged on the lower surface of the protrusion, a second spring is arranged between the groove and the card slot to apply an upward thrust to the protrusion, a first transmission groove corresponding to the rotating plate is arranged on the side wall of the protrusion, a sliding ball arranged at one end of the rotating plate is slidably located in the first transmission groove, and a sliding ball arranged at the other end of the rotating plate is slidably located in the second transmission groove, the second transmission groove is arranged on the lifting block, a locking pin is arranged on the upper surface of the lifting block, and a third spring is arranged between the lifting block and the second mounting groove to apply a downward thrust to the lifting block.

6. A high-precision vascular fluid dynamics detection device according to claim 5, characterized in that: A testing mechanism for testing the fixing mechanism is arranged on one side of the fixing mechanism, and the testing mechanism includes a nuclear magnetic resonance detector, a protective shell is arranged on the outside of the nuclear magnetic resonance detector, a workbench is arranged on one side of the protective shell, a base is placed on the workbench, a guide rail for guiding the sliding of the base is arranged on the workbench, a power element for driving the base to slide horizontally along the guide rail is arranged inside the protective shell, a mounting plate is arranged inside the protective shell, an intermediate guide rail for guiding the sliding of the base is arranged on the mounting plate, a protective door is arranged on one side of the protective shell close to the base, and a door closing structure for closing the protective door is arranged on the mounting plate; the door closing structure includes a transmission gear, The transmission gear is rotatably connected to the mounting plate, a rack meshing with the transmission gear is provided on the base, a first gear is provided on the axle of the transmission gear, the first gear is meshed with a second gear rotatably provided on the mounting plate, an intermediate gear is provided on the axle of the second gear, the intermediate gear is meshed with the first rack and the second rack, the first rack and the second rack are respectively arranged at the bottom ends of the two protective doors, the first rack and the second rack are respectively located on both sides of the intermediate gear, a guide hole that guides the sliding of the protective door is provided on the mounting plate, a connecting block provided on the protective door is located in the guide hole and slides along the guide hole, and the first rack and the second rack are respectively arranged on the connecting blocks on the two protective doors.

7. A high-precision detection device for vascular fluid dynamics according to claim 6, characterized in that: A clamping table is arranged above the connecting plate, and the sample is fixed on the clamping table. One end of the sample is connected to the liquid outlet of the circulation pump through a tee and a connecting pipe. Pressure sensors for detecting the pressure of the test fluid in the sample are arranged at both ends of the sample. The other end of the sample is connected to the liquid inlet of the circulation pump through a connecting pipe. A liquid inlet pipe is arranged on the tee, and a control valve is arranged on the liquid inlet pipe.

8. A detection method, characterized in that: The high-precision detection device for vascular fluid mechanics according to claim 7 comprises the following steps: S1. Place the connecting plate on the fixing seat, insert the mounting block into the first mounting groove, apply downward pressure to the protrusion, and the protrusion slides downward along the card slot, the protrusion drives one end of the rotating plate to rotate, and the other end of the rotating plate drives the lifting block to move upward, the lifting block drives the locking pin to move upward, the locking pin is inserted into the second sliding hole, and the card pin is inserted into the card hole of the locking pin under the action of the second spring, so as to realize the locking of the connecting plate on the fixing seat; S2. Fix the sample on the clamping table; pull the fixed shaft outward through the handle, and the fixed shaft drives the locking plate to slide outward through the rotating plate and the connecting rod, the locking plate is separated from the positioning plate, the fixing pin slides along the limit groove, the rotating plate is rotated, the connecting rod slides in the slide groove, the fixing pin slides along the rotating groove, and under the action of the first spring, the fixing pin is clamped in the rotating groove to fix the locking plate; rotate the transmission plate through the knob and the rotating shaft, and the transmission plate drives the fixing seat to rotate through the support rod to adjust the position of the sample; S3, the rotating plate is rotated in the opposite direction. Under the action of the first spring, the locking plate contacts the positioning plate, and the fixing pin cannot rotate in the limiting groove, thereby locking and positioning the rotating shaft; the angle adjustment of the sample is completed; S4. Connect the circulation pump to both ends of the sample through the connecting pipe, connect the connecting pipe to the liquid inlet end of the sample through the tee, open the control valve, inject the test fluid into the sample through the tee, and close the control valve; turn on the circulation pump, the circulation pump drives the test fluid in the sample to flow, and detect the pressure of the test fluid in the sample through the pressure sensor. After the pressure stabilizes, perform the test; S5. The base is driven by a power element to slide along the guide rail on the workbench, and the base enters the protective shell through the middle guide rail. As the base slides, the transmission rack on the base meshes with the transmission gear, driving the transmission gear to rotate. The transmission gear drives the middle gear to rotate through the first gear and the second gear. The middle gear drives the first rack and the second rack to slide relative to each other, thereby driving the two protective doors to slide relative to each other. After the base completely slides into the protective shell, the protective door is closed, and the sample is tested by a nuclear magnetic resonance detector.

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