Sample processing apparatus

Abstract

The invention provides a sample treatment device which comprises a pipe body, a dropper cover and a sampling rod, the top of the sampling rod extends into the bottom of the dropper cover and is fixedly connected with the dropper cover, a hollow cavity is formed in the sampling rod in the axis direction of the sampling rod, an opening is formed in the top of the cavity and is communicated with a dropper of the dropper cover, and the bottom of the cavity is closed. A first filtering part is arranged on the sampling rod, a plurality of filtering holes are formed in the outer surface of the first filtering part, an activated carbon layer is arranged in the first filtering part, and a plurality of liquid inlet holes communicated with the cavity are formed in the outer wall of the sampling rod in the coverage range of the first filtering part. According to the invention, pigment filtration of a sample mixed solution in the sample treatment device can be realized after a sampling rod collects an excrement sample into the tube body, so that the color of the sample solution is clearer, and detection personnel can conveniently read a detection result without influencing the detection result, so that the detection efficiency is improved. The method has good application value in detection of bacterial infection and virus infection with excrement as a detection sample.

Description

Technical Field

[0001] The present invention relates to the technical field of medical detection equipment, and in particular to a sample processing device for collecting feces. Background Art

[0002] Hepatitis A virus (HAV) belongs to the genus Hepatovirus of the family Picornaviridae. It is a single-stranded small RNA virus with an average diameter of about 27nm and no viral envelope. Hepatitis A (abbreviated as HAV) is a type of viral hepatitis caused by HAV. It is mainly transmitted through the fecal-oral route, that is, the HAV in the feces and blood of the patient during the latent or acute period contaminates the water source, food, utensils and close contact in daily life and enters the gastrointestinal tract through the mouth.

[0003] Hepatitis A virus infection is highly contagious and is the main cause of acute hepatitis. Its clinical manifestations are similar to other acute hepatitis. Jaundice occurs in some cases, and asymptomatic infection is common. The general population is susceptible, mainly children and adolescents. The clinical symptoms of hepatitis A in adults are generally more severe than those in children. The incubation period is usually 14 to 49 days, with an average of 30 days. Studies have shown that hepatitis A patients can excrete HAV in their feces in the second half of the incubation period. By detecting HAV in feces, the source of infection can be discovered as early as possible and the spread can be controlled at the source.

[0004] Currently, there are no special hepatitis A virus antigen detection kits on the market. The detection of antigens is carried out by different manufacturers or scientific research institutions according to their own needs. At present, the commonly used detection methods in laboratories include virus isolation and culture, reverse transcription-polymerase chain reaction (RT-PCR), enzyme-linked immunosorbent assay (ELISA), etc. These methods have shortcomings in the detection process, such as long time consumption, special instruments and equipment, and high technical support, which brings certain difficulties to the diagnosis of HAV. Colloidal gold immunochromatography technology is an immunoassay technology developed in the 1980s. It has the advantages of being fast, simple, and intuitive to read the results. It has broad application prospects in disease detection.

[0005] Feces, as human waste, become test samples for detecting bacteria, virus infections and other related indicators. It has the advantages of less damage to the human body and convenient sampling. Because the composition of fecal samples is complex, individual differences are large, and the content of the substance to be detected is low, it is generally necessary to collect a small amount of sample from the original feces with a sampling stick before testing, and then insert the sampling stick into the sampling bottle, dilute and mix with the processing liquid in the sampling bottle, and finally take a certain amount of the mixed solution for testing.

[0006] When routinely collecting stool samples, the sampling stick is usually used alone. After collecting the stool sample, it needs to be inserted into the tube body and mixed with the processing liquid before being taken out and discarded. This is not only inconvenient to use, but also the sample may splash or drip onto the test table during the removal process, causing contamination.

[0007] And when testing stool samples, due to the high complexity and heterogeneity of stool samples, it is usually necessary to pre-treat the samples to remove possible interfering substances, such as food residues, microorganisms, sloughed epithelial cells and mucus. For test strip products that use immunochromatography to detect target substances in stool, although the residual substances in the stool sample liquid can be intercepted by the sample pad, the pigment in the stool sample will still interfere with the background of the test strip, affecting the tester's interpretation of the results and reducing the detection efficiency. Summary of the invention

[0008] In order to solve the above technical problems, the present invention provides a sample processing device, which comprises a chamber connected to a dripper in a sampling rod, a first filter element with a built-in activated carbon layer on the sampling rod, and a liquid inlet hole on the side wall of the section of the sampling rod wrapped by the first filter element. After the sampling rod collects the fecal sample into a tube body and mixes it with the processing liquid, the sample solution can be discharged by pouring the tube body without pulling out the sampling rod, which makes it more convenient and clean to use. At the same time, the first filter element is used to filter the pigment of the sample solution, so that the color of the sample solution is clearer, which can facilitate the detection personnel to read the test results without affecting the test results.

[0009] A sample processing device comprises a tube body, a dripper cover arranged on the top of the tube body and a sampling rod inserted in the tube body, the top of the sampling rod extends to the bottom of the dripper cover and is fixedly connected thereto, a hollow chamber is arranged inside the sampling rod along its axial direction, an opening is arranged at the top of the chamber and is connected to the dripper on the dripper cover, the bottom of the chamber is closed to form a sampling part, a first filter is wrapped outside the section of the sampling rod adjacent to the bottom of the dripper cover, a plurality of filter holes are opened on the outer surface of the first filter, an activated carbon layer is arranged inside the first filter A plurality of liquid inlet holes connected to the chamber are provided on the side wall of the section of the sampling rod wrapped by the first filter element. After the sampling rod extracts the sample, it is inserted into the tube body and the sample is dissolved in the liquid in the tube body to form a sample solution. The sample processing device is then turned upside down so that the dripper on the dripper cover faces downward. The sample solution drips out from the dripper through the first filter element and the liquid inlet holes and the chamber on the sampling rod. The activated carbon layer inside the first filter element at least absorbs part of the pigment in the sample solution, thereby reducing the pigment content in the dripping sample solution.

[0010] A further technical solution is that at least two liquid inlet holes with different directions or heights are arranged on the side wall of the sampling rod.

[0011] A further technical solution is: a second filter is wrapped on the outer side of the sampling rod near one end of the sampling part, and an activated carbon layer is arranged inside the second filter. After the sampling rod extracts the sample, it is inserted into the tube body and the tube body is shaken to dissolve the sample into the liquid in the tube body to form a sample solution. During this process, the activated carbon layer in the second filter element at least absorbs part of the pigment in the sample solution, thereby further reducing the pigment content in the dripping sample solution.

[0012] A further technical solution is that the first filter element and the second filter element are fixed around the outer wall of the sampling rod and the cross section is set to be circular, and the sample solution can only enter the chamber of the sampling rod through the first filter element. A further technical solution is that the activated carbon layer uses an activated carbon cotton net or an activated carbon filter element.

[0013] A further technical solution is: the activated carbon layer uses an activated carbon cotton net or an activated carbon filter element.

[0014] A further technical solution is: a filter residue layer is further arranged inside the first filter element, and the filter residue layer is wrapped around the outside of the activated carbon layer.

[0015] A further technical solution is that the filter residue layer is made of glass fiber, sponge or absorbent cotton.

[0016] A further technical solution is that the surface of the sampling portion is arranged as a spiral surface with a thread structure.

[0017] A further technical solution is that the surface of the sampling portion can be arranged to have a plurality of evenly distributed protrusions.

[0018] A further technical solution is that the surface of the sampling part is wrapped with cotton or sponge.

[0019] The beneficial effect of the present invention is that a chamber connected to the dripper is provided inside the sampling rod, and a liquid inlet hole connected to the chamber is provided on the side wall of the sampling rod. When in use, the sample liquid can be discharged by tilting the tube body, and the sampling rod does not need to be taken out and discarded, which is more convenient and clean to use.

[0020] The present application provides a first filter element on the outside of the sampling rod, and provides a filter residue layer and an activated carbon layer arranged in sequence from the outside to the inside of the first filter element. Large particles of residue in the sample liquid are filtered through the filter residue layer to prevent clogging of the liquid inlet and the chamber, thereby ensuring that the sample liquid flows smoothly out of the dripper; the strong adsorption capacity of activated carbon is utilized to intercept the pigment molecules in the fecal sample, so that the color of the sample liquid is clearer, the cleanliness of the test strip is improved, and the interference of the pigment in the fecal sample on the test background is reduced without affecting the test results, so that the test personnel can read the test results on the test strip conveniently.

[0021] The present application arranges the first filter element to be fixed on the outside of the sampling rod, thereby reducing the limitation of the size of the first filter element on the size of the chamber space in the sampling rod. The first filter element can have a larger size, and more activated carbon materials can be placed in the first filter element, thereby greatly improving the adsorption effect of the first filter element on the pigment in the sample solution, greatly reducing the content of the pigment in the sample solution, and further reducing the interference of the pigment in the fecal sample on the detection background, thereby improving the accuracy of the test results read by the test personnel on the test strip.

[0022] The present application constructs multiple different sample liquid flow paths by setting multiple liquid inlet holes at different directions or heights on the side wall of the sampling rod, and cooperates with the first filter element arranged in an annular manner to enable the first filter element to exert the maximum filtering efficiency. It is convenient for the sample liquid to flow to the chamber after being filtered by the first filter element, and to flow out from the dripper through the chamber. It also reduces the risk of liquid flow being blocked by fecal residue in the tube body, ensuring smooth liquid discharge. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a schematic structural diagram of a sample processing device of the present invention covered with a cover.

[0024] Figure 2 It is a schematic structural diagram of the sample processing device of the present invention with the cover opened.

[0025] Figure 3 is a schematic diagram of the sampling rod.

[0026] Figure 4 is a cross-sectional view of the sampling rod.

[0027] Figure 5 is a schematic diagram of the second filter element.

[0028] Figure 6 yes Figure 4 A schematic diagram of one embodiment of the invention is shown in FIG.

[0029] Figure 7 yes Figure 4 A schematic diagram of another embodiment of the present invention is shown in FIG.

[0030] Figure 8 yes Figure 4 A schematic diagram of one embodiment at B in FIG.

[0031] Fig. 9 yes Figure 4 A schematic diagram of another embodiment is shown at B in FIG.

[0032] Fig.10 It is a schematic diagram of the structure of a hepatitis A antigen test strip.

[0033] Fig.11This is a schematic diagram of detecting a sample using a sample processing device.

[0034] Reference numerals: 10. Sample processing device, 1. Tube body, 2. Drip head cover, 21. First cover body, 22. Second cover body, 23. Drip head, 24. Sealing cap, 3. Sampling rod, 31. Sampling part, 32. Chamber, 33. Liquid inlet, 4. First filter element, 41. Filter hole, 5. Activated carbon layer, 6. Filter residue layer, 7. Cotton, 8. Second filter element, 20. Test strip, 201. Sample pad, 202. Marking pad, 203. Detection pad, 204. Absorbent pad, 205. Bottom card, 30. Reagent box. DETAILED DESCRIPTION

[0035] like Figure 1 and Figure 2 A sample processing device 10 shown includes a tube body 1 , a dripper cover 2 arranged on the top of the tube body 1 , and a sampling rod 3 inserted into the tube body 1 .

[0036] The tube body 1 is provided with an opening at the top, and a thread is provided on the outer wall of the opening of the tube body 1. The dripper cover 2 includes a first cover body 21 threadedly connected to the opening at the top of the tube body 1, a second cover body 22 arranged on the top of the first cover body 21, and a dripper 23 arranged on the top of the second cover body 22. The first cover body 21, the second cover body 22 and the dripper 23 are coaxially arranged, and a through cavity is provided inside the dripper 23 along its axial direction. The cavity is connected to the tube body 1, so that the sample liquid inside the tube body 1 can flow out of the cavity. A sealing cap 24 for sealing the dripper 23 is threadedly connected to the outer wall of the second cover body 22.

[0037] like Figure 2-Figure 5 As shown, the top of the sampling rod 3 extends to the bottom of the dripper cover 2 and is fixedly connected thereto, a hollow chamber 32 is provided inside the sampling rod 3 along its axial direction, an opening is provided at the top of the chamber 32 and is communicated with the dripper 23 of the dripper cover 2, the bottom of the chamber 32 is closed to form a sampling portion 31, and a first filter element 4 is wrapped around the outside of the section of the sampling rod 3 adjacent to the bottom of the dripper cover 2, a plurality of filter holes 41 are provided on the outer surface of the first filter element 4, an activated carbon layer 5 is provided inside the first filter element 4, and a plurality of liquid inlet holes 33 communicated with the chamber 32 are provided on the side wall of the section of the sampling rod 3 wrapped by the first filter element 4.

[0038] In one embodiment, the top of the sampling rod 3 is integrally connected to the bottom of the dripper cover 2. In another embodiment, a connecting tube extending downward is provided in the dripper cover 2, the interior of the connecting tube is interconnected with the cavity of the dripper 23, and the sampling rod 3 is snapped into the interior of the connecting tube, so that the chamber 32 of the sampling rod 3 is interconnected with the connecting tube.

[0039] The number of the liquid inlet holes 33 can be set to one or more. Figure 6 As shown, at least two liquid inlet holes 33 in different directions or heights are provided on the side wall of the sampling rod 3. The sample liquid can enter the chamber 32 after passing through the first filter element 4 from multiple different paths, so that the sample liquid is fully filtered and the flow rate of the sample liquid is increased.

[0040] The number of filters can be set to one. In one embodiment, the first filter 4 is disposed on the sampling rod 3 adjacent to the bottom of the dripper cover 2. After the sample and the treatment liquid are fully mixed, the sample processing device 10 is poured, and the sample liquid in the tube body 1 is filtered through the first filter 4 and then flows out from the dripper 23. Further, after the sampling rod 3 extracts the sample, it is inserted into the tube body 1 and the sample is dissolved in the liquid in the tube body to form a sample solution. Then, the sample processing device is turned upside down so that the dripper 23 on the dripper cover faces downward, and the sample solution drips out from the dripper 23 through the first filter 4 and the liquid inlet hole 33 and the chamber 32 on the sampling rod. The activated carbon layer 5 inside the first filter at least absorbs part of the pigment in the sample solution, thereby reducing the pigment content in the dripped sample solution.

[0041] In order to achieve better filtering effect, multiple filter elements can be provided. Figure 5 As shown, in another embodiment, in addition to the first filter 4, the outer side surface of the sampling rod 3 near the end of the sampling portion 31 is also wrapped with a second filter 8, and the outer surface of the second filter 8 is provided with a plurality of filter holes, and an activated carbon layer is arranged in the second filter 8. After the sampling rod 3 extracts the sample, it is inserted into the tube body 1 and the sample is dissolved into the liquid in the tube body by shaking the tube body 1 to form a sample solution. The activated carbon layer in the second filter 8 at least absorbs part of the pigment in the sample solution, thereby further reducing the pigment content in the dripping sample solution. When the fecal sample is mixed with the treatment liquid in the tube body 1 by shaking the tube body 1, it can be filtered once through the second filter 8 near the sampling portion 31, and when pouring, it can be filtered twice through the first filter 4 near the dripper 23, and the pigment filtering effect is better.

[0042] The first filter element 4 and the second filter element 8 are fixed around the outer wall of the sampling rod 3. The cross-sections of the first filter element 4 and the second filter element 8 can be set to be square, trapezoidal or triangular. In a preferred embodiment, the cross-sections of the first filter element 4 and the second filter element 8 are set to be circular, which can increase the contact area between the activated carbon layer 5 and the sample solution, so that the sample solution can be fully filtered. And the sample solution can only enter the chamber 32 of the sampling rod through the first filter element 4.

[0043] The diameter of the filter holes 41 on the first filter element 4 and the second filter element 8 is sufficient to prevent the activated carbon layer 5 from falling out. Specifically, the activated carbon layer 5 can be filled with an activated carbon cotton net or an activated carbon filter element. The sample liquid is filtered through the rich pore structure and strong adsorption inside the activated carbon, and the pigment molecules in the fecal sample are intercepted by physical adsorption.

[0044] The activated carbon layer 5 can be made of a whole piece of activated carbon and processed into a shape suitable for the first / second filter cavity, such as a ring or a hollow cylinder, and then assembled into the first / second filter; it can also be made of powdered raw materials and binders through kneading, extrusion molding, carbonization, activation and other processes to form a shape suitable for the first / second filter cavity, or powdered activated carbon plus a binder can be extruded and then assembled into the first / second filter. The first / second filter is a hollow cylindrical sleeve fixed on the sampling rod 3.

[0045] Further, such as Figure 7 As shown, a filter residue layer 6 is also provided inside the first filter element 4, and the filter residue layer 6 is wrapped around the outside of the activated carbon layer 5. By providing the filter residue layer 6 to pre-treat the sample liquid, large particles of fecal residue in the sample liquid can be filtered out first to avoid clogging the first filter element 4 and the liquid inlet 33, thereby affecting the flow of the sample liquid. Specifically, the filter residue layer 6 is made of glass fiber, sponge or absorbent cotton.

[0046] The bottom end of the sampling rod 3 is provided with a sampling portion 31. In order to allow the sampling portion 31 to pick up a sufficient amount of sample at one time, the surface of the sampling portion 31 is set to be an uneven or irregular surface to enhance the adhesion to the sample so that the sample is not easily dropped during the picking process. Specifically, in one embodiment, Figure 8 As shown, the surface of the sampling portion 31 is configured as a spiral surface with a thread structure, so that the surface of the sampling portion 31 has multiple spiral grooves, which can obtain more fecal samples, avoid the sampler from operating multiple times, reduce discomfort, and is not easy to drop when picking up, reducing contamination. In an optional embodiment, the surface of the sampling portion 31 can be configured to have multiple evenly distributed protrusions, which can retain a sufficient amount of fecal samples in the gaps between the protrusions. In another optional embodiment, as Fig. 9 As shown, the surface of the sampling portion 31 may also be wrapped with cotton 7 or sponge, and a sufficient amount of feces sample may be collected at one time by utilizing the water absorption of the cotton 7 or sponge.

[0047] The tube body 1, the dripper cover 2 and the sampling rod 3 of the sample processing device 10 are all made of polyethylene. The tube body 1 of the sample processing device 10 is transparent or translucent, which is convenient for observing the internal situation of the sample processing device.

[0048] In order to facilitate the smooth outflow of the sample liquid in the sample processing device, a part of the tube body 1 of the sample processing device can be set to be elastic, so that the tube body 1 can be squeezed conveniently, so that the tube body 1 is deformed, and the sample liquid in the tube body 1 is accelerated to flow to the chamber 32 of the sampling rod 3 and out of the dripper 23. In one embodiment, the shape of the tube body 1 can be set to be cylindrical. In another embodiment, the shape of the tube body 1 is set to be a truncated cone with a cross-section gradually increasing from bottom to top, so that the tester can squeeze the tail of the tube body 1 to accelerate the flow of the sample liquid inside the tube body 1.

[0049] When the present invention is in use, the dripper cover 2 is unscrewed, a sufficient amount of feces sample is collected through the sampling rod 3, the collected feces sample is added to the sample processing device 10, and then fully mixed with the sample processing liquid in the tube body 1 to obtain a sample liquid, and then the tube body 1 is poured, so that the sample liquid passes through the first filter element 4 and then enters the chamber 32 through the liquid inlet hole 33, and drips onto the test strip through the dripper 23 through the chamber 32.

[0050] Detection experiment verification 1. Preparation of test materials 1. Experimental group: sample processing device with first filter element 2. Comparative group: sample processing device without the first filter element 3. Collect 10 stool samples from Hangzhou Aidikang Medical Testing Center: 5 negative samples, coded as N1, N2, N3, N4, N5; 5 positive samples, coded as P1, P2, P3, P4, P5. Use the experimental group and the control group to test the above 10 samples at the same time.

[0051] 4. Verification product: Hepatitis A antigen test strips 20 (1) Test strip components: Quality control area (C): goat anti-mouse IgG polyclonal antibody Test area (T): HAV antibody-1 Label pad: HAV antibody-2 Sample treatment solution: sodium chloride (0.09%) + EDTA (0.5%) (2) Preparation of test strip 20: The test strip 20 includes a sample pad 201, a marking pad 202, a detection pad 203, a water-absorbing pad 204 and a bottom card 205. The water-absorbing pad 204 is made of absorbent paper.

[0052] Preparation of the detection pad 203. The detection pad 203 uses a nitrocellulose membrane (NC membrane) as a carrier, and there are two lines on the NC membrane, namely the detection line T line and the control line C line. The detection line T line is fixed with HAV antibody-1, with a concentration of 1.0 mg / ml, the dilution buffer is PB buffer, and the pH is 7.0~8.0. The quality control line C line is fixed with sheep anti-mouse IgG polyclonal antibody, with a concentration of 0.5 mg / ml, the dilution buffer is PB buffer, and the pH is 7.0~8.0. The T line and the C line are fixed on the NC membrane by a film dispenser. After the film dispenser is processed, the detection pad can be placed in a 37°C oven for drying.

[0053] Preparation of the marking pad 202: The marking pad 202 uses glass fiber as a carrier, and the marking solution is processed on the glass fiber by a spraying machine. The marking solution can be obtained by mixing HAV antibody-2 and latex microspheres for covalent coupling, and the concentration is 0.2%, wherein the dilution buffer is 0.05M Tris+0.5% BSA. After the spraying machine is processed, the marking pad is placed in a 37°C oven for drying.

[0054] Preparation of sample pad 201. Sample pad 201 uses glass fiber as a carrier, and sprays the sample pad treatment solution on the glass fiber. The sample pad treatment solution is: 0.05M Tris+0.5% Tween-20+0.5% BSA+ 0.2% Proclin 300. The treated sample pad is placed in a 37°C oven for drying.

[0055] Assemble the test strip 20. Assemble the processed structures according to the conventional test strips. Fig.10 In the order shown, the detection pad 203 is assembled first, one end of the absorbent pad 204 covers the downstream end of the detection pad 203, the downstream end of the marking pad 202 covers the upstream end of the detection pad 203, and the downstream end of the sample pad 201 covers the upstream end of the marking pad 202. The assembled sample pad 201, marking pad 202, detection pad 203 and absorbent pad 204 are all fixed on the bottom card 205.

[0056] (3) Test strip principle Highly specific antigen-antibody reaction and immunochromatography techniques are used to qualitatively detect whether the stool sample contains HAV antigen. The reagent contains HAV antibody-1 that is pre-fixed in the test area (T line) on the nitrocellulose membrane and goat anti-mouse IgG polyclonal antibody in the quality control area (C line). The labeled HAV antibody-2 is contained in the label pad. During the test, the HAV antigen in the sample combines with the labeled antibody-2 to form a complex. Under the action of chromatography, the complex moves forward along the nitrocellulose membrane, and when passing through the test area (T line), it combines with the HAV antibody-1 coated on the membrane, forming a red reaction band in the test area (T line). The labeled HAV antibody-2 moves to the quality control area (C line) and combines with the coated goat anti-mouse IgG polyclonal antibody to form a red band. Negative samples will not have red bands in the test area (T line), but only in the quality control area (C line). Regardless of whether the sample contains HAV virus antigen, a red band will be formed in the quality control area (C line) as a standard for judging whether the chromatography process is normal.

[0057] (II) Testing process: Allow stool samples to return to 15°C to 30°C before testing.

[0058] 1. Sample preparation (1) Unscrew the drip cap of the sample processing device 10 and take out the sampling rod 3 to prepare for picking samples.

[0059] (2) Use the sampling stick 3 to pick up stool samples from at least 4 different locations, about 125 mg, and then insert the samples into the sample processing device containing the sample processing solution.

[0060] (3) Tighten the drip cap and cover of the sample processing device.

[0061] (4) Shake thoroughly to mix the sample and sample treatment solution thoroughly.

[0062] 2. Detection (1) Take out the reagent kit 30, which contains the hepatitis A antigen test strip 20 prepared in step (i), and place the reagent kit 30 on a clean and flat table. Keep the sample processing device 10 with the tube opening facing upward, unscrew the cover at the top of the sample processing device, and then turn the sample processing device upside down. Fig.11 As shown, gently squeeze the sample processing device and vertically drip 3 drops of bubble-free sample solution into the reagent sample adding area of ​​the hepatitis A antigen detection test strip 20 of the reagent kit 30.

[0063] (2) Wait for the red strip to appear and read the test result in 15 to 20 minutes.

[0064] 3. Test results interpretation Standard color card: The colorimetric range of the standard color card is between 0-10, that is, L0-L10. The color degree increases from 0 to 10. When the color degree of the test line T line is between L3 (including L3)-L10, the test result is positive. When the color degree of the test line T line is between L0-L3 (excluding L3), the test result is negative.

[0065] The test line T of the test strip is compared with the standard color card, and the test results are shown in Table 1.

[0066] Table 1 Sample test results

[0067] Judging from the test results, adding the first filter will not affect the accuracy and sensitivity of positive and negative detection. For samples treated with activated carbon, the detection background is cleaner, and the color of the detection line of the positive sample will be more obvious than the background. Especially for weakly positive samples, the positive judgment will be clearer and more definite.

Claims

1. A sample processing device, comprising a tube body, a dripper cover arranged on the top of the tube body and a sampling rod inserted into the tube body, characterized in that: The top of the sampling rod extends to the bottom of the dripper cover and is fixedly connected thereto, a hollow chamber is provided inside the sampling rod along its axial direction, an opening is provided at the top of the chamber and is connected to the dripper on the dripper cover, and the bottom of the chamber is closed to form a sampling portion, a first filter is wrapped around the outside of the section of the sampling rod adjacent to the bottom of the dripper cover, a plurality of filter holes are provided on the outer surface of the first filter, an activated carbon layer is provided inside the first filter, a plurality of liquid inlet holes connected to the chamber are provided on the side wall of the section of the sampling rod wrapped by the first filter, after the sampling rod extracts the sample, it is inserted into the tube body and the sample is dissolved in the liquid in the tube body to form a sample solution, and then the sample processing device is turned upside down so that the dripper on the dripper cover faces downward, and the sample solution drips out from the dripper through the first filter and the liquid inlet hole and chamber on the sampling rod, and the activated carbon layer inside the first filter adsorbs at least part of the pigment in the sample solution, thereby reducing the pigment content in the dripped sample solution.

2. The sample processing device according to claim 1, characterized in that: At least two liquid inlet holes with different directions or heights are arranged on the side wall of the sampling rod.

3. The sample processing device according to claim 1, characterized in that: The outer side surface of the sampling rod near one end of the sampling part is also wrapped with a second filter element, and an activated carbon layer is arranged inside the second filter element. After the sampling rod extracts the sample, it is inserted into the tube body and the tube body is shaken to dissolve the sample into the liquid in the tube body to form a sample solution. In this process, the activated carbon layer in the second filter element at least absorbs part of the pigment in the sample solution, thereby further reducing the pigment content in the dripping sample solution.

4. The sample processing device according to claim 3, characterized in that: The first filter element and the second filter element are fixed around the outer wall of the sampling rod and the cross section is set to be circular. The sample solution can only enter the chamber of the sampling rod through the first filter element.

5. The sample processing device according to claim 1 or 3, characterized in that: The activated carbon layer uses an activated carbon cotton net or an activated carbon filter element.

6. The sample processing device according to claim 1, characterized in that: A filter residue layer is also arranged inside the first filter element, and the filter residue layer is wrapped around the outer side of the activated carbon layer.

7. The sample processing device according to claim 6, characterized in that: The filter residue layer is made of glass fiber, sponge or absorbent cotton.

8. The sample processing device according to claim 1, characterized in that: The surface of the sampling portion is configured as a spiral surface having a thread structure.

9. The sample processing device according to claim 1, characterized in that: The surface of the sampling portion may be configured to have a plurality of evenly distributed protrusions.

10. The sample processing device according to claim 1, characterized in that: The surface of the sampling part is wrapped with cotton or sponge.

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