Tightening and wrinkle fading composition and application thereof in eye cream

Abstract

The invention relates to a wrinkle tightening and fading composition and application thereof in eye cream. The wrinkle tightening and fading composition comprises a plant extract and polypeptide, the plant extract comprises butyrospermum parkii butter, crocus sativus extract, zingiber zingiberensis extract and chamomilla recutita flower oil. The four plant extract components including butyrospermum parkii butter, crocus sativus extract, zingiber zingiberensis extract and chamomilla recutita flower oil are creatively combined with polypeptide and can interact with one another, so that the moisturizing, tightening and wrinkle-lightening cream has a synergistic promotion effect which is unexpected by technicians in the field on moisturizing, tightening and wrinkle-lightening effects, and the moisturizing, tightening and wrinkle-lightening cream has a good moisturizing, tightening and wrinkle-lightening effect. And the four plant extract components also have a remarkable synergistic interaction effect. The tightening and wrinkle fading composition provided by the invention is very suitable for skin care products such as eye cream and the like, and is mild, non-irritant and good in stability.

Description

Technical Field

[0001] The invention belongs to the field of cosmetics and relates to a wrinkle-tightening and wrinkle-lightening composition and application thereof in eye cream. Background Art

[0002] The human skin is an important barrier that prevents the loss of water, electrolytes and other substances in the body and blocks the invasion of harmful external substances. The integrity of the skin barrier is essential to maintaining skin health. The skin barrier protects the body from the external environment, including the invasion of harmful microorganisms, chemicals, pollutants and physical damage (such as ultraviolet radiation). The skin barrier helps maintain the moisture of the skin and prevents excessive water loss, thereby keeping the skin soft and elastic. Compared with other parts of the skin, the skin around the eyes is thinner and more sensitive, the subcutaneous tissue is weak, the collagen content is lower than other parts, and the skin's accessory structures, including sweat glands and sebaceous glands, are also less distributed, resulting in local lack of moisture and oil, prone to wrinkles, and easy aging.

[0003] Frequent irregular lifestyles such as staying up late and overeating can easily lead to reduced blood circulation around the eyes, which in turn leads to a series of eye problems such as eye swelling, increased eye wrinkles, crow's feet, etc. An important cause of wrinkles is the lack of water content in the skin of the relevant parts. The skin can only metabolize normally when it is well hydrated. Therefore, it is necessary to fully achieve the balance of water and oil in the skin through efficient moisturizing, and at the same time try to use some natural and mild ingredients to soothe the skin, so as to effectively improve the firmness of the eye skin and reduce the lines. Therefore, it is of great significance to provide a mild cosmetic that can efficiently moisturize and has the effect of firming and reducing lines. Summary of the invention

[0004] In view of the deficiencies of the prior art, the object of the present invention is to provide a wrinkle-tightening and wrinkle-lightening composition and its application in eye cream.

[0005] In order to achieve the purpose of the invention, the present invention adopts the following technical solutions:

[0006] In a first aspect, the present invention provides a wrinkle-tightening and wrinkle-lightening composition, the wrinkle-tightening and wrinkle-lightening composition comprising a plant extract and a polypeptide;

[0007] The plant extracts include avocado butter, saffron extract, ginger extract and chamomile oil.

[0008] In the present invention, plant extracts and polypeptides are used in combination, and it is found that the plant extract components and polypeptides can cooperate synergistically and have a better effect in tightening and reducing wrinkles.

[0009] In addition, avocado tree fat is rich in unsaturated fatty acids, which can enhance the skin's moisturizing ability and moisturize dry skin, that is, skin with damaged keratin. At the same time, it can adjust the fluidity of the product, improve viscosity, and enhance the sensory quality and skin feel of the product; saffron extract is a natural ingredient extracted from saffron, mainly composed of pigment components, volatile oils and various organic compounds in the petals, with whitening, anti-oxidation, moisturizing and other effects, can effectively improve skin pigmentation and dullness, enhance skin resistance, and delay the aging process of the skin; red ball ginger extract has an inhibitory effect on the activity of elastase and tyrosinase, and can promote collagen production, with excellent anti-wrinkle and anti-aging effects; chamomile oil is an essential oil extracted from chamomile, with calming, soothing, anti-inflammatory and antioxidant effects.

[0010] In the present invention, the above four specific plant extracts are used in combination, and it is found that they have significant synergistic effects in terms of moisturizing and tightening wrinkles.

[0011] Preferably, the mass ratio of the plant extract and the polypeptide is (0.1-4):(0.05-5), for example, it can be 4:0.05, 4:0.1, 4:0.5, 4:1, 1:1, 4:3, 4:5, 1:2, 1:3, 1:4, 1:5, 0.5:5, 0.1:5, etc. Other specific point values ​​within this numerical range can be selected, and they will not be described one by one here.

[0012] In the present invention, when the dosage ratio of the plant extract and the polypeptide is within the above specific range, it has a better wrinkle tightening and lightening effect.

[0013] Preferably, the polypeptide comprises any one or a combination of at least two of oligopeptide-215, palmitoyl pentapeptide-4, acetyl hexapeptide-8, conopeptide, carnosine or acetyl tetrapeptide-5.

[0014] Preferably, the plant extract comprises, by weight, 0.5-12 parts of avocado butter, 0.01-2 parts of saffron extract, 0.1-5 parts of ginger extract and 0.1-5 parts of chamomile oil;

[0015] The above “0.5-12 parts” may be, for example, 0.5 parts, 1 parts, 1.5 parts, 2 parts, 4 parts, 5 parts, 8 parts, 10 parts, 12 parts, etc.;

[0016] The above-mentioned “0.01-2 parts” can be, for example, 0.01 parts, 0.05 parts, 0.1 parts, 0.15 parts, 0.2 parts, 0.5 parts, 0.8 parts, 1 parts, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, etc.;

[0017] The above-mentioned "0.1-5 parts" can be, for example, 0.1 parts, 0.2 parts, 0.5 parts, 0.8 parts, 1 parts, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 5 parts, etc. Other specific point values ​​within the numerical range can be selected, and they will not be elaborated here one by one.

[0018] In the present invention, when the dosage ratio of each component in the plant extract is within the above specific range, it has a better effect of tightening and lightening wrinkles.

[0019] The avocado oil and chamomile oil components involved in the present invention are not limited to their specific preparation processes and sources, and products obtained by conventional extraction and preparation processes and regular commercially available products can be used in the scheme of the present invention.

[0020] The saffron extract involved in the present invention is not limited to its specific preparation process. When it is prepared by the following process, its synergistic effect with the other three components in tightening and reducing wrinkles is more significant.

[0021] Preferably, the saffron extract is prepared by a preparation method comprising the following steps:

[0022] The saffron, complex enzyme and water are mixed, ultrasonicated, filtered to obtain a filtrate, and the filtrate is concentrated and dried to obtain the saffron extract;

[0023] The complex enzyme comprises a combination of pectinase, β-glucosidase and flavor protease.

[0024] In the present invention, it is unexpectedly found that when a composite enzyme solution containing three enzymes, namely pectinase, β-glucanidase and flavor protease, is used to perform enzymatic hydrolysis and extraction of active substances in saffron, the combination of the three enzymes can synergistically enhance the effect and obtain a better extraction effect. The prepared saffron extract has higher activity and better effect. In addition, enzymatic hydrolysis is carried out under ultrasonic conditions, which can further enhance the enzymatic hydrolysis effect and obtain a saffron extract with better effect.

[0025] Preferably, the mass ratio of pectinase, β-glucanidase and flavor protease is (2-8):(1-5):(0.1-2);

[0026] The above “2-8” may be, for example, 2, 2.5, 3, 3.5, 4, 4.5, 5, 5.5, 6, 6.5, 7, 7.5, 8, etc.;

[0027] The above-mentioned “1-5” may be, for example, 1, 1.5, 2, 2.5, 3, 3.5, 4, 4.5, 5, etc.;

[0028] The above-mentioned "0.1-2" can be, for example, 0.1, 0.2, 0.4, 0.5, 0.6, 0.8, 1, 1.2, 1.4, 1.5, 1.6, 1.8, 2, etc. Other specific point values ​​within this numerical range can be selected, and they will not be elaborated here one by one.

[0029] In the present invention, when the dosage ratio of the three enzymes in the composite enzyme is within the above-mentioned specific range, the enzymatic extraction effect of saffron can be further improved.

[0030] Preferably, the added amount of the complex enzyme is 0.1‰-1‰ of the mass of saffron, for example, it can be 0.1‰, 0.15‰, 0.2‰, 0.25‰, 0.3‰, 0.5‰, 0.6‰, 0.7‰, 0.8‰, 0.9‰, 1‰, etc. Other specific point values ​​within this numerical range can be selected, and they will not be described one by one here.

[0031] Preferably, the liquid ratio of saffron to water is 1g:(40-90)mL, for example, it can be 1g:40mL, 1g:45mL, 1g:50mL, 1g:55mL, 1g:60mL, 1g:65mL, 1g:70mL, 1g:72mL, 1g:75mL, 1g:80mL, 1g:85mL, 1g:90mL, etc. Other specific point values ​​within this numerical range can be selected, which will not be described here one by one.

[0032] Preferably, the ultrasonic power is 200-400 W, for example 200 W, 250 W, 300 W, 350 W, 400 W, etc., and the enzymatic hydrolysis time is 5-30 min, for example 5 min, 7 min, 10 min, 12 min, 15 min, 20 min, 22 min, 25 min, 30 min, etc. Other specific point values ​​within the numerical range can be selected, which will not be described here one by one.

[0033] The ginger extract involved in the present invention is not limited to its specific preparation process. When it is prepared by the following process, its synergistic effect with the other three components in tightening and reducing wrinkles is more significant.

[0034] Preferably, the Zingiber officinale extract is prepared by a preparation method comprising the following steps:

[0035] Subjecting red ginger to subcritical extraction, filtering to obtain a filtrate, concentrating and drying the filtrate to obtain the red ginger extract;

[0036] When subcritical extraction is used to extract the red ginger raw material, the extraction effect can be further improved. Compared with conventional hot water reflux extraction, the nutrients and bioactive substances in the red ginger can be extracted more effectively, and the obtained extract has a better anti-wrinkle and line-reducing effect.

[0037] Preferably, the solid-liquid ratio of the red ginger to the subcritical extraction solvent is 1g:(15-40)mL, for example, it can be 1g:15mL, 1g:18mL, 1g:20mL, 1g:22mL, 1g:25mL, 1g:28mL, 1g:30mL, 1g:32mL, 1g:35mL, 1g:38mL, 1g:40mL, etc. Other specific point values ​​within this numerical range can be selected, and they will not be described one by one here.

[0038] Preferably, the temperature of the subcritical extraction is 120-180°C, for example, it can be 120°C, 125°C, 130°C, 135°C, 140°C, 145°C, 150°C, 160°C, 165°C, 170°C, 180°C, etc.; the time is 30-60min, for example, it can be 30min, 35min, 40min, 45min, 50min, 55min, 60min, and other specific point values ​​within the numerical range can be selected, which will not be described here one by one.

[0039] In a second aspect, the present invention provides a use of the wrinkle-reducing and firming composition according to the first aspect in cosmetics;

[0040] The cosmetics include lotions, creams, skin care water, skin care essences or facial masks.

[0041] In a third aspect, the present invention provides a firming and wrinkle-lightening eye cream, which comprises 0.1-10 parts by mass of the firming and wrinkle-lightening composition described in the first aspect.

[0042] The above “0.1-10 parts” can be, for example, 0.1 parts, 0.2 parts, 0.5 parts, 0.8 parts, 1 parts, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 8 parts, 10 parts, etc.;

[0043] Preferably, the firming and wrinkle-reducing eye cream further comprises, by weight, any one of 2-30 parts of moisturizer, 2-25 parts of emulsifier, 2-15 parts of emollient, 0.1-1 part of thickener, 0.5-3 parts of skin conditioner, 0.0005-0.01 parts of pH adjuster, 0.1-0.5 parts of antioxidant, 0.01-0.1 parts of chelating agent or 40-70 parts of water, or a combination of at least two of them.

[0044] The above “2-30 parts” may be, for example, 2 parts, 5 parts, 8 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, 28 parts, 30 parts, etc.;

[0045] The above-mentioned “2-25 parts” can be, for example, 2 parts, 5 parts, 8 parts, 10 parts, 12 parts, 15 parts, 18 parts, 20 parts, 22 parts, 25 parts, etc.;

[0046] The above-mentioned “2-15 parts” can be, for example, 2 parts, 3 parts, 4 parts, 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, etc.;

[0047] The above-mentioned “0.1-1 part” can be, for example, 0.1 part, 0.2 part, 0.3 part, 0.4 part, 0.5 part, 0.6 part, 0.7 part, 0.8 part, 0.9 part, 1 part, etc.;

[0048] The above-mentioned “0.5-3 parts” can be, for example, 0.5 parts, 0.6 parts, 0.7 parts, 0.8 parts, 0.9 parts, 1 parts, 1.2 parts, 1.5 parts, 1.8 parts, 2 parts, 2.2 parts, 2.5 parts, 2.8 parts, 3 parts, etc.;

[0049] The above-mentioned “0.0005-0.01 part” can be, for example, 0.0005 part, 0.001 part, 0.0015 part, 0.002 part, 0.004 part, 0.005 part, 0.006 part, 0.007 part, 0.008 part, 0.009 part, 0.01 part, etc.;

[0050] The above-mentioned “0.1-0.5 parts” can be, for example, 0.1 parts, 0.15 parts, 0.2 parts, 0.25 parts, 0.3 parts, 0.35 parts, 0.4 parts, 0.45 parts, 0.5 parts, etc.;

[0051] The above-mentioned “0.01-0.1 part” can be, for example, 0.01 part, 0.02 part, 0.03 part, 0.04 part, 0.05 part, 0.06 part, 0.07 part, 0.08 part, 0.09 part, 0.1 part, etc.;

[0052] The above-mentioned "40-70 parts" can be, for example, 40 parts, 42 parts, 45 parts, 48 ​​parts, 50 parts, 52 parts, 55 parts, 58 parts, 60 parts, 62 parts, 65 parts, 68 parts, 70 parts, etc. Other specific point values ​​within the numerical range can be selected, and they will not be elaborated here one by one.

[0053] Preferably, the moisturizing agent includes any one of dimethicone, squalane, glycerin, β-glucan, propylene glycol, 1,2-pentanediol, 1,2-hexanediol, caprylyl glycol, aminomethyl propanol, hydrogenated lecithin or saccharide isomers, or a combination of at least two thereof.

[0054] Preferably, the emulsifier includes any one of polyglyceryl-6 distearate, polyglyceryl-3 beeswax acid ester, cetyl alcohol, cetearyl alcohol, behenyl alcohol, acrylates / C10-30 alkyl acrylate crosspolymer, sodium stearoyl glutamate, sodium acrylate / sodium acryloyldimethyl taurate copolymer, sorbitan oleate or PPG-13-decyltetradecyl alcohol polyether-24, or a combination of at least two thereof.

[0055] Preferably, the emollient comprises any one of jojoba esters, butylene glycol dicaprylate / dicaprate, pentaerythritol tetra(ethylhexanoate), myristyl myristate, isohexadecane or polysorbate-80, or a combination of at least two thereof.

[0056] Preferably, the thickener comprises any one of xanthan gum, carbomer or ethyl cellulose, or a combination of at least two thereof.

[0057] Preferably, the skin conditioning agent comprises any one of β-alanylhydroxyprolyldiaminobutyric acid benzylamine, nicotinic acid ester, lactic acid bacteria fermentation product or yeast fermentation product, or a combination of at least two thereof.

[0058] Preferably, the pH adjuster comprises citric acid and / or arginine.

[0059] Preferably, the antioxidant comprises tocopherol acetate and / or sodium metabisulfite.

[0060] Preferably, the chelating agent comprises disodium EDTA and / or sodium citrate.

[0061] Compared with the prior art, the present invention has the following beneficial effects:

[0062] In the present invention, a polypeptide and a plant extract are used in combination to synergistically promote the firming and wrinkle-reducing effect of the composition, and four specific plant extract ingredients, namely, avocado tree butter, saffron extract, red ginger extract and chamomile oil, are used. It is found that the four components can interact with each other and have a positive influence on each other, and have a synergistic promotion effect in terms of moisturizing and firming and wrinkle-reducing effects that is difficult for technicians in this field to predict, and can further enhance the moisturizing and anti-wrinkle effects of the product. DETAILED DESCRIPTION

[0063] In order to further explain the technical means and effects adopted by the present invention, the technical solution of the present invention is further described below in conjunction with the preferred embodiments of the present invention, but the present invention is not limited to the scope of the embodiments.

[0064] The avocado butter involved in the following comes from Foshan Xinan Chemical Trading Co., Ltd. SB 45 product, the key active ingredient of avocado tree fat is stearyl palmitate; chamomile oil comes from Feike's German chamomile oil product, and the key active ingredient of chamomile oil is α-neemol ketone; the complex peptide (oligopeptide-215+palmitoyl pentapeptide-4+acetyl hexapeptide-8+cono peptide+carnosine) comes from the multi peptide product of Shenzhen Vichy Technology Co., Ltd.; acetyl tetrapeptide-5 comes from Guangzhou Boyan Chemical Technology Co., Ltd. product; pectinase was purchased from Shanghai MacLean Biochemical Technology Co., Ltd. M6346 product; β-glucosidase was purchased from Shanghai Aladdin Biochemical Technology Co., Ltd. G755171 product; flavor protease was purchased from Shanghai MacLean Biochemical Technology Co., Ltd. F861436 product. Mixed fermentation products (lactic acid bacteria fermentation products + yeast fermentation products) came from Guangdong MaruMei Biotechnology Co., Ltd. Products; sugar isomers come from PENTAVITIN products of Guangzhou Runpei Chemical Co., Ltd.

[0065] The weight percentages of the composite peptides, acetyl tetrapeptide-5, related commercially available plant extracts, sugar isomers, and mixed fermentation products mentioned below are all calculated based on the actual content of the effective ingredients contained in the commercially available raw materials. The commercially available raw materials may also selectively contain any one or a combination of at least two of solvents, moisturizers, thickeners, fillers, diluents, stabilizers, pH adjusters, antibacterial agents, antioxidants, or impurities within the permitted range.

[0066] Preparation Example 1

[0067] This preparation example provides a saffron extract, which is prepared by the following method:

[0068] (1) After freeze-dried and ground saffron, it was mixed with a composite enzyme and water, the amount of composite enzyme added was 0.5‰ of the mass of saffron, the solid-liquid ratio of saffron to water was 1 g:60 mL, wherein the composite enzyme consisted of pectinase, β-glucosidase and flavor protease in a mass ratio of 5:2:1, and ultrasonic enzymatic hydrolysis and extraction were performed at a constant temperature of 50°C, wherein the ultrasonic condition was 300W for 25 min;

[0069] (2) After the ultrasonic extract is filtered, the filtrate is collected, the filter residue is mixed with water, the ultrasonic extraction process in step (1) and the filtration step in step (2) are repeated once, the combined filtrate is collected, and freeze-dried to obtain a saffron extract.

[0070] This preparation example also provides a red ginger extract, which is prepared by the following method:

[0071] The red ginger powder was subjected to subcritical extraction at 150°C with water as the extractant at a solid-liquid ratio of 1g:30mL for 40 minutes, and the filtrate was filtered to obtain a filtrate. The filtrate was concentrated under reduced pressure to remove the solvent, and then freeze-dried to obtain a red ginger extract.

[0072] Preparation Example 2

[0073] This preparation example provides a saffron extract, which is prepared by the following method:

[0074] (1) After freeze-dried and ground saffron, it was mixed with a composite enzyme and water, the amount of composite enzyme added was 0.25‰ of the mass of saffron, the solid-liquid ratio of saffron to water was 1 g:40 mL, wherein the composite enzyme was composed of pectinase, β-glucosidase and flavor protease in a mass ratio of 2:4.5:1.8, and ultrasonic enzymatic hydrolysis and extraction were performed at a constant temperature of 55°C, wherein the ultrasonic condition was 350W ultrasound for 10 min;

[0075] (2) After the ultrasonic extract is filtered, the filtrate is collected, the filter residue is mixed with water, the ultrasonic extraction process in step (1) and the filtration step in step (2) are repeated once, the combined filtrate is collected, and freeze-dried to obtain a saffron extract.

[0076] This preparation example also provides a red ginger extract, which is prepared by the following method:

[0077] The red ginger powder was subjected to subcritical extraction at 160°C with water as the extractant at a solid-liquid ratio of 1g:35mL for 35 minutes, and the filtrate was filtered to obtain a filtrate. The filtrate was concentrated under reduced pressure to remove the solvent, and then freeze-dried to obtain the red ginger extract.

[0078] Preparation Example 3

[0079] This preparation example provides a saffron extract, which is prepared by the following method:

[0080] (1) After freeze-dried and ground saffron, it was mixed with a composite enzyme and water, wherein the amount of the composite enzyme added was 0.8‰ of the mass of saffron, and the solid-liquid ratio of saffron to water was 1 g:80 mL, wherein the composite enzyme consisted of pectinase, β-glucanidase and flavor protease in a mass ratio of 7:1:0.2, and ultrasonic enzymatic hydrolysis and extraction were performed at a constant temperature of 55°C, wherein the ultrasonic condition was 240W ultrasound for 28 min;

[0081] (2) After the ultrasonic extract is filtered, the filtrate is collected, the filter residue is mixed with water, the ultrasonic extraction process in step (1) and the filtration step in step (2) are repeated once, the combined filtrate is collected, and freeze-dried to obtain a saffron extract.

[0082] This preparation example also provides a red ginger extract, which is prepared by the following method:

[0083] The red ginger powder was subjected to subcritical extraction at 130°C with water as the extractant at a solid-liquid ratio of 1g:15mL for 50 minutes, and the filtrate was filtered to obtain a filtrate. The filtrate was concentrated under reduced pressure to remove the solvent, and then freeze-dried to obtain the red ginger extract.

[0084] Preparation Example 4

[0085] This preparation example provides a saffron extract, which uses the freeze-dried and ground saffron of Preparation Example 1. The preparation method thereof is different from that of Preparation Example 1 only in the enzyme composition in the complex enzyme, that is, pectinase is not contained, and the reduced portion thereof is proportionally distributed to β-glucosidase and flavor protease. Other processing processes and related parameters are referred to Preparation Example 1.

[0086] Preparation Example 5

[0087] This preparation example provides a saffron extract, which uses the freeze-dried and ground saffron of Preparation Example 1. The preparation method thereof differs from that of Preparation Example 1 only in the enzyme composition in the complex enzyme, that is, β-glucosidase is not included, and its reduced portion is proportionally distributed to pectinase and flavor protease. Other processing processes and related parameters are referred to Preparation Example 1.

[0088] Preparation Example 6

[0089] This preparation example provides a saffron extract, which uses the freeze-dried and ground saffron of Preparation Example 1. The preparation method thereof is different from that of Preparation Example 1 only in the enzyme composition in the complex enzyme, that is, flavor protease is not contained, and its reduced portion is proportionally distributed to pectinase and β-glucosidase. Other processing processes and related parameters are referred to Preparation Example 1.

[0090] Preparation Example 7

[0091] This preparation example provides a red ginger extract, which is prepared by the following method:

[0092] The red ginger was crushed and sieved, mixed with water at a solid-liquid ratio of 1g:15mL, heated under reflux for extraction for 3.5h, the filtrate was filtered with filter paper after extraction, concentrated and freeze-dried to obtain the red ginger extract.

[0093] Example 1

[0094] The present embodiment provides a firming and wrinkle-reducing composition, which is composed, by mass, of 6 parts of avocado tree fat, 1 part of saffron extract (Preparation Example 1), 2 parts of red ball ginger extract (Preparation Example 1), 2 parts of chamomile oil, 2 parts of composite peptides (oligopeptide-215+palmitoyl pentapeptide-4+acetyl hexapeptide-8+cono peptide+carnosine) and 6 parts of acetyl tetrapeptide-5.

[0095] Example 2

[0096] The present embodiment provides a firming and wrinkle-reducing composition, which is composed, by mass, of 2 parts of avocado tree fat, 1.5 parts of saffron extract (Preparation Example 2), 5 parts of red ball ginger extract (Preparation Example 2), 2.5 parts of chamomile oil, 0.5 parts of composite peptides (oligopeptide-215+palmitoyl pentapeptide-4+acetyl hexapeptide-8+cono peptide+carnosine) and 4 parts of acetyl tetrapeptide-5.

[0097] Example 3

[0098] The present embodiment provides a firming and wrinkle-reducing composition, which is composed, by mass, of 10 parts of avocado tree fat, 0.1 parts of saffron extract (Preparation Example 3), 1 part of red ball ginger extract (Preparation Example 3), 0.9 parts of chamomile oil, 4 parts of composite peptides (oligopeptide-215+palmitoyl pentapeptide-4+acetyl hexapeptide-8+cono peptide+carnosine) and 7 parts of acetyl tetrapeptide-5.

[0099] Example 4

[0100] This embodiment provides a wrinkle-tightening and wrinkle-reducing composition, which differs from Embodiment 1 only in that the saffron extract (Preparation Example 1) used is replaced with an equal amount of saffron extract (Preparation Example 4).

[0101] Example 5

[0102] This embodiment provides a wrinkle-tightening and wrinkle-reducing composition, which differs from Embodiment 1 only in that the saffron extract (Preparation Example 1) used is replaced with an equal amount of saffron extract (Preparation Example 5).

[0103] Example 6

[0104] This embodiment provides a wrinkle-tightening and wrinkle-reducing composition, which differs from Embodiment 1 only in that the saffron extract (Preparation Example 1) used is replaced with an equal amount of saffron extract (Preparation Example 6).

[0105] Example 7

[0106] This embodiment provides a wrinkle-tightening and wrinkle-reducing composition, which differs from Embodiment 1 only in that the Zingiber officinale extract (Preparation Example 1) is replaced with an equal amount of Zingiber officinale extract (Preparation Example 7).

[0107] Comparative Example 1

[0108] This comparative example provides a firming and wrinkle-lightening composition, which differs from Example 1 only in that it does not contain avocado butter, and the reduced amount of avocado butter is proportionally distributed among the three components of saffron extract, ginger extract and chamomile oil.

[0109] Comparative Example 2

[0110] This comparative example provides a wrinkle-reducing and firming composition, which differs from Example 1 only in that it does not contain saffron extract, and the reduced amount of saffron extract is proportionally distributed among the three components of avocado tree butter, red ginger extract and chamomile oil.

[0111] Comparative Example 3

[0112] This comparative example provides a wrinkle-reducing and firming composition, which differs from Example 1 only in that it does not contain the Zingiber officinale extract, and the reduced amount of the extract is proportionally distributed among the three components of avocado tree butter, saffron extract and chamomile oil.

[0113] Comparative Example 4

[0114] This comparative example provides a firming and wrinkle-lightening composition, which differs from Example 1 only in that it does not contain chamomile oil, and the reduced amount of chamomile oil is proportionally distributed among the three components of avocado tree butter, saffron extract and ginger extract.

[0115] Comparative Example 5

[0116] This comparative example provides a firming and wrinkle-reducing composition, which differs from Example 1 only in that it does not contain complex peptide and acetyl tetrapeptide-5, and the reduced amounts of these two components are proportionally distributed to four plant extract components: avocado tree butter, saffron extract, red ball ginger extract and chamomile oil.

[0117] Comparative Example 6

[0118] This comparative example provides a firming and wrinkle-reducing composition, which differs from Example 1 only in that it does not contain the four plant extracts of avocado tree butter, saffron extract, red ball ginger extract and chamomile oil, and the reduced amounts of the four plant extracts are proportionally distributed to the two components of the complex peptide and acetyl tetrapeptide-5.

[0119] Application Example 1

[0120] This application example provides a firming and wrinkle-lightening eye cream, the formula of which is as follows:

[0121]

[0122]

[0123] Its preparation method is:

[0124] (1) Add the first moisturizer, the first emulsifier, the first emollient, the antioxidant and the wrinkle-reducing composition (avocado butter) into the oil phase pot, stir and heat to 75° C., and keep warm for 10 minutes.

[0125] (2) Add the second moisturizer, the second emulsifier, the thickener, the chelating agent (ETDA disodium) and part of the water into the water phase pot, stir and heat to 80°C, and keep warm for 10 minutes.

[0126] (3) After the insulation is completed, the mixture in the water phase pot and the oil phase pot is pumped into the emulsifier pot, homogenized at 2500 rpm for 8 minutes, and then aminomethyl propanol, part of the water, sodium acrylate / sodium acryloyldimethyl taurate copolymer, isohexadecane, polysorbate-80, and sorbitan oleate are added, homogenized at 2000 rpm for 8 minutes, cooled to 45°C, and the remaining raw material components are added, and stirred at 500 rpm for 10 minutes to prepare an eye cream product.

[0127] Application Example 2-7

[0128] This application example provides six types of firming and wrinkle-lightening eye creams, the formulas of which differ from those of the application examples only in that the compositions prepared in Example 1 are replaced with equal amounts of compositions prepared in Examples 2-7, respectively, and other ingredients and contents remain unchanged. The preparation method refers to that in Application Example 1.

[0129] Comparative Application Examples 1-6

[0130] This comparative application example provides six types of firming and wrinkle-lightening eye creams, the formulas of which differ from those of the application examples only in that the compositions prepared in Example 1 are replaced with equal amounts of compositions prepared in Comparative Examples 1-6, respectively, and other ingredients and contents remain unchanged. The preparation method refers to that in Application Example 1.

[0131] Test Example 1

[0132] Matrix Efficacy Test Screening

[0133] (1) Select healthy Chinese women with a facial lactic acid sting test (LAST) score of >3, dry, rough, dull, loose facial skin, sensitive and red facial skin, obvious nasolabial folds, under-eye wrinkles, caudal eye wrinkles, and tear troughs. The subjects had no allergic diseases, no history of allergies to cosmetics and other topical preparations, and were used to using basic moisturizing lotions and lotions / creams on a daily basis. A total of 78 subjects were included, with an age range of 35-60 years old and an average age of 46.3±5.6 years old. The subjects were divided into 13 groups, with 6 people in each group. After arriving at the laboratory, the subjects cleaned their faces with facial cleanser, sat quietly for 30 minutes, performed a half-face test on the skin, applied the product and massaged it until it was absorbed for 30 minutes, and then tested the skin again. The changes before and after the skin were statistically analyzed to obtain the change rate.

[0134] (2) Test items include:

[0135] The moisture content of the stratum corneum of the skin was tested using the Corneometer CM 825 (Courage & Khazaka, Germany);

[0136] Skin elasticity and firmness were tested using the Cutometer MPA580 (Courage & Khazaka, Germany).

[0137] (3) The wrinkle-reducing and firming compositions of Examples 1-7 and Comparative Examples 1-6 were dissolved in pure water respectively, so that the concentration of the compositions in each group of samples was 5%, and tested. The test environment was at a temperature of 20° C. and a humidity of 50%, which met the requirements of the scheme design. The improvement after using the product (%) = (data after use - data before use) / data before use × 100%. The results are shown in Table 1:

[0138] Table 1

[0139]

[0140] From the data in the table we can see that:

[0141] (1) It can be seen from Examples 1 to 3 that the wrinkle-reducing and firming composition provided by the present invention has significant moisturizing and firming effects, among which Example 1 has the best effect.

[0142] (2) By comparing Example 1 with Examples 4-6, it can be seen that the saffron extract in the present invention is enzymatically extracted by a composite enzyme consisting of pectinase, β-glucanidase and flavor protease. The three enzymes can synergistically promote the enzymatic hydrolysis effect after being used in combination, further improving the extraction effect of the relevant active ingredients in saffron, and obtaining a saffron extract with better effect.

[0143] (3) By comparing Example 1 with Example 7, it can be seen that the red ginger extract prepared by subcritical extraction in the present invention has a better effect than the red ginger extract prepared by traditional heating reflux.

[0144] (4) By comparing Example 1 with Comparative Examples 1-4, it can be seen that when Comparative Examples 1-4 do not contain any of the four components of avocado oil, saffron extract, ginger extract and chamomile oil, the prepared compositions have worse moisturizing and skin tightening effects than those of Example 1. It can be seen that the four components of avocado oil, saffron extract, ginger extract and chamomile oil used in the present invention can cooperate with each other, synergistically enhance the effect, and improve the skin condition.

[0145] (5) By comparing Example 1 with Comparative Examples 5-6, it can be seen that the combination of the polypeptide and the plant extract component in the present invention can synergistically enhance the moisturizing and firming effects of the product.

[0146] Test Example 2

[0147] Eye cream efficacy test

[0148] (1) Select healthy Chinese women with a facial lactic acid sting test (LAST) score of >3, dry, rough, dull, loose facial skin, sensitive and red facial skin, obvious nasolabial folds, under-eye wrinkles, caudal eye wrinkles, and tear troughs. The subjects had no allergic diseases, no history of allergies to cosmetics and other topical preparations, and were used to using basic moisturizing lotions and lotions / creams on a daily basis. A total of 78 subjects were included, with an age range of 35-60 years old and an average age of 46.3±5.6 years old. The subjects were divided into 13 groups, with 6 people in each group.

[0149] (2) After cleansing and using toner every night, the subjects took an appropriate amount of eye cream and evenly applied it around the eyes. Gently apply it to the skin around the eyes and the nasolabial folds. Use the gilded crystal massage head to gently massage the eye area from the inside to the outside and from the bottom to the top until it is absorbed. Use it once a day for 28 consecutive days. Statistical analysis of the changes before and after the skin was performed to obtain the change rate.

[0150] (3) Test items include:

[0151] Corneometer CM 825 is a skin stratum corneum moisture tester that tests the moisture content of the skin stratum corneum.

[0152] Cutometer MPA580 tests skin elasticity R2 and firmness F4;

[0153] Skin melanin and hemoglobin tester Mexameter MX18 tests the skin hemoglobin and melanin content;

[0154] Glossymeter GL 200 is used to test skin glossiness;

[0155] The skin fast optical imaging system Evaskin-S5 tests the roughness of the under-eye wrinkles.

[0156] (3) The test product is the eye cream product prepared in Application Examples 1-7 and Comparative Application Examples 1-6. The test environment is 20° C. and 50% humidity, which meets the requirements of the scheme design. The improvement after using the product (%) = (data after use - data before use) / data before use × 100%. The results are shown in Table 2:

[0157] Table 2

[0158]

[0159] The data in the table show that the combination of polypeptide and plant extract components in the present invention can synergistically enhance the soothing, moisturizing and firming and wrinkle-lightening effects of the product. In addition, avocado tree butter, saffron extract, ginger extract and chamomile oil are used as plant extract components, and the four components also have a certain synergistic effect in soothing, moisturizing and firming and wrinkle-lightening effects.

[0160] Test Example 3

[0161] Eye cream product wrinkle reduction effect test

[0162] (1) The subject selection criteria and product usage were the same as those in Test Example 2. The skin fast optical imaging system Evaskin-S5 was used to test and record the improvement effects of the subjects' nasolabial folds, tear troughs, under-eye wrinkles and caudal wrinkles.

[0163] (2) The test product is the eye cream product prepared in Application Example 1, and the test environment is a temperature of 20° C. and a humidity of 50%, which meets the requirements of the scheme design; the improvement after using the product (%) = (data after use - data before use) / data before use × 100%; the results are shown in Table 3:

[0164] Table 3

[0165]

[0166] It can be seen from the data in the table that the eye cream product prepared by the present invention has an excellent anti-wrinkle effect. The compound use of polypeptides and four specific plant extracts makes the product have a good effect of reducing various wrinkles and has an excellent firming effect.

[0167] Test Example 4

[0168] Product safety testing

[0169] According to the inclusion criteria, 35 women and 35 men were selected to participate in the test and randomly divided into 7 groups (5 men and 5 women in each group) to receive the trial. Take an appropriate amount of sample and place it in the chamber of the spot test tape. Apply the spot tester with the sample to the skin on the curved side of the forearm of the subject with medical tape for 24 hours. 30 minutes after removing the test spot tester, observe the skin reaction after the indentation disappears. For those with negative results, observe again 24 hours and 48 hours after the test, and record the skin reaction results. The reaction degree grading standard is as shown in the following table.

[0170]

[0171] The results show that the products prepared in Application Examples 1-7 showed negative reactions 24h and 48h after the test, and there was no irritation or erythema. It can be seen that the eye cream product prepared by the present invention has no irritation to the skin and no positive reaction, which proves that the product is highly safe, less irritating, and milder.

[0172] The applicant declares that the present invention illustrates the technical solution of the present invention through the above-mentioned embodiments, but the present invention is not limited to the above-mentioned embodiments, that is, it does not mean that the present invention must rely on the above-mentioned embodiments to be implemented. Those skilled in the art should understand that any improvement of the present invention, equivalent replacement of various raw materials of the product of the present invention, addition of auxiliary components, selection of specific methods, etc., all fall within the protection scope and disclosure scope of the present invention.

[0173] The preferred embodiments of the present invention are described in detail above. However, the present invention is not limited to the specific details in the above embodiments. Within the technical concept of the present invention, a variety of simple modifications can be made to the technical solution of the present invention, and these simple modifications all belong to the protection scope of the present invention.

[0174] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any suitable manner without contradiction. In order to avoid unnecessary repetition, the present invention will not further describe various possible combinations.

Claims

1. A wrinkle-reducing composition, characterized in that: The wrinkle tightening and lightening composition comprises plant extracts and polypeptides; The plant extracts include avocado butter, saffron extract, ginger extract and chamomile oil.

2. The wrinkle-reducing and firming composition according to claim 1, characterized in that: The mass ratio of the plant extract to the polypeptide is (0.1-4):(0.05-5); Preferably, the polypeptide comprises any one or a combination of at least two of oligopeptide-215, palmitoyl pentapeptide-4, acetyl hexapeptide-8, conopeptide, carnosine or acetyl tetrapeptide-5.

3. The wrinkle-reducing and firming composition according to claim 1, characterized in that: The plant extract comprises, by weight, 0.5-12 parts of avocado tree butter, 0.01-2 parts of saffron extract, 0.1-5 parts of ginger extract and 0.1-5 parts of chamomile oil.

4. The wrinkle-reducing and firming composition according to claim 1 or 3, characterized in that: The saffron extract is prepared by a preparation method comprising the following steps: The saffron, complex enzyme and water are mixed, ultrasonicated, filtered to obtain a filtrate, and the filtrate is concentrated and dried to obtain the saffron extract; The complex enzyme comprises a combination of pectinase, β-glucosidase and flavor protease.

5. The wrinkle-reducing and firming composition according to claim 4, characterized in that: The mass ratio of pectinase, β-glucanidase and flavor protease is (2-8):(1-5):(0.1-2); Preferably, the added amount of the complex enzyme is 0.1‰-1‰ of the mass of saffron; Preferably, the solid-liquid ratio of saffron to water is 1 g: (40-90) mL.

6. The wrinkle-reducing and firming composition according to claim 1 or 3, characterized in that: The ginger extract is prepared by a preparation method comprising the following steps: The red ginger is subjected to subcritical extraction, filtered to obtain a filtrate, and the filtrate is concentrated and dried to obtain the red ginger extract.

7. Use of the wrinkle-reducing composition according to any one of claims 1 to 6 in cosmetics; The cosmetics include lotions, creams, skin care water, skin care essences or facial masks.

8. A firming and wrinkle-lightening eye cream, characterized in that: The firming and wrinkle-reducing eye cream comprises 0.1-10 parts by mass of the firming and wrinkle-reducing composition according to any one of claims 1 to 6.

9. The wrinkle-reducing eye cream according to claim 8, characterized in that: The firming and wrinkle-lightening eye cream also includes, by weight, any one of 2-30 parts of moisturizer, 2-25 parts of emulsifier, 2-15 parts of emollient, 0.1-1 part of thickener, 0.5-3 parts of skin conditioner, 0.0005-0.01 part of pH adjuster, 0.1-0.5 part of antioxidant, 0.01-0.1 part of chelating agent or 40-70 parts of water, or a combination of at least two of them.

10. The wrinkle-reducing eye cream according to claim 9, characterized in that: The moisturizing agent includes any one of polydimethylsiloxane, squalane, glycerin, β-glucan, propylene glycol, 1,2-pentanediol, 1,2-hexanediol, caprylyl glycol, aminomethyl propanol, hydrogenated lecithin or sugar isomers, or a combination of at least two thereof; Preferably, the emulsifier includes any one of polyglyceryl-6 distearate, polyglyceryl-3 beeswax acid ester, cetyl alcohol, cetearyl alcohol, behenyl alcohol, acrylates / C10-30 alkyl acrylate crosspolymer, sodium stearoyl glutamate, sodium acrylate / sodium acryloyldimethyl taurate copolymer, sorbitan oleate or PPG-13-decyltetradecyl alcohol polyether-24, or a combination of at least two thereof; Preferably, the emollient comprises any one or a combination of at least two of jojoba esters, butylene glycol dicaprylate / dicaprate, pentaerythritol tetra(ethylhexanoate), myristyl myristate, isohexadecane or polysorbate-80; Preferably, the thickener comprises any one of xanthan gum, carbomer or ethyl cellulose or a combination of at least two thereof; Preferably, the skin conditioning agent comprises any one or a combination of at least two of β-alanylhydroxyprolyldiaminobutyric acid benzylamine, nicotinate, lactic acid bacteria fermentation products or yeast fermentation products; Preferably, the pH adjuster comprises citric acid and / or arginine; Preferably, the antioxidant comprises tocopherol acetate and / or sodium metabisulfite; Preferably, the chelating agent comprises disodium EDTA and / or sodium citrate.

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