Repairing and relieving liposome composition as well as preparation method and application thereof

Abstract

The invention relates to the technical field of raw materials of skin care products, and particularly discloses a repairing and relieving liposome composition as well as a preparation method and application thereof. The repairing and relieving liposome composition comprises the following components in parts by mass: 11.3-21.1 parts of a solvent; 55 to 75 parts of a humectant; 2-10 parts of an emulsifier; 3.6 to 5.6 parts of a skin conditioner; 10 to 25 parts of emollient; 0.2 to 1 part of an antioxidant; 0.2 to 1 part of centella asiatica extract; 1-5 parts of a kava pepper root extract; 0.5 to 0.7 part of rosa roxburghii tratt fruit extract; and 0.1-0.7 part of a ginger root extract. The skin-care lotion has excellent effects of moisturizing, resisting oxidation, relieving, resisting inflammation and the like, and has the advantages of high safety and suitability for various skin types.

Description

Technical Field

[0001] The invention relates to the field of skin care product raw materials, and in particular to a repairing and soothing liposome composition, a preparation method and application thereof. Background Art

[0002] Skin care products are products used to protect the skin. Repairing the skin with skin care products can make the skin healthier.

[0003] There are many skin problems, so skin care products also have different functions to solve skin problems in a targeted manner. Among them, the soothing effect can relieve skin discomfort and has a better repair effect on damaged skin, becoming one of the hot functions.

[0004] However, although existing skin care products can meet the needs of consumers to a certain extent, their skin soothing effects are relatively general and the effects are slow to take effect. Currently, it is difficult to meet consumers' needs for quick relief of skin discomfort. Therefore, there is still room for improvement. Summary of the invention

[0005] In order to further improve the soothing effect, the present application provides a repairing and soothing liposome composition, a preparation method and an application thereof.

[0006] In the first aspect, the present application provides a repairing and soothing liposome composition, which adopts the following technical solution: A repairing and soothing liposome composition, comprising the following components in parts by weight: 11.3-21.1 parts of solvent; Moisturizer 60-64 parts; Emulsifier 1.3-1.7 parts; Skin conditioning agent 3.6-5.6 parts; Emollient 11-13 parts; Antioxidant 0.2-0.3 parts; Centella asiatica extract 0.5-1 part; Kava root extract 1.3-1.7 parts; 0.5-0.7 parts of roxburghii fruit extract; Ginger root extract 0.5-0.7 parts.

[0007] By adopting the above technical scheme, by adding Centella asiatica extract, Kava root extract, Rosa roxburghii fruit extract, and ginger root extract in a specific proportion, the active ingredients of Centella asiatica extract, Kava root extract, Rosa roxburghii fruit extract, and ginger root extract cooperate with each other, which can play a very significant antioxidant and soothing effect, so that the repairing and soothing liposome composition has good effects in moisturizing, anti-oxidation, soothing, anti-inflammatory and other aspects, so that it can comprehensively repair the skin well, restore the skin to health, quickly eliminate skin discomfort, and meet the needs of consumers well.

[0008] Preferably, the emollient is a mixture of one or more of caprylic / capric triglyceride, octyldodecanol, squalane, jojoba seed oil, and sunflower seed oil.

[0009] Preferably, the emollient is a compound of caprylic / capric triglyceride and squalane.

[0010] Preferably, the mass ratio of caprylic / capric triglyceride to squalane is 5.5-6.5:5.5-6.5.

[0011] By adopting the above technical scheme, the emollients are a compound of caprylic / capric triglyceride and squalane, so that the repairing and soothing liposome composition can soften the skin well, make the skin more moisturized, and have a better skin care effect.

[0012] Preferably, the emulsifier is a mixture of one or more of soybean lecithin, egg yolk lecithin, hydrogenated lecithin, hydroxylated lecithin, phosphatidylcholine, phosphatidyldiethanolamine, and cholesterol.

[0013] Preferably, the emulsifier is soy lecithin.

[0014] By adopting the above technical solution and using soybean lecithin as the emulsifier, the repairing and soothing liposome composition is more stable and the product quality is better.

[0015] Preferably, the skin conditioning agent is a mixture of one or more of asiatica glycoside, madecassoside, bisabolol, stearyl glycyrrhetinate, and hydroxyphenylpropionamide benzoic acid.

[0016] Preferably, the skin conditioning agent is a compound of asiatica glycoside, madecassoside, bisabolol, stearyl glycyrrhetinate and hydroxyphenylpropionamide benzoic acid.

[0017] Preferably, the mass ratio of asiatica glycoside, madecassoside, bisabolol, stearyl glycyrrhetinate, and hydroxyphenylpropionamide benzoic acid is 0.5-1:0.5-1:0.5-0.7:1.3-1.7:0.8-1.2.

[0018] By adopting the above technical scheme, the skin conditioning agents are compounded with Centella asiatica, Madecassoside, Bisabolol, Stearyl Glycyrrhetinate and Hydroxyphenylpropionamide benzoic acid, so that the anti-inflammatory effect of the repairing and soothing liposome composition is better, and the skin can be repaired better and faster, and the needs of consumers for quick relief of skin discomfort can be better met.

[0019] Preferably, the moisturizing agent is one or a mixture of 1,3-propylene glycol, 1,3-butylene glycol, glycerol, dipropylene glycol, and 1,2-hexanediol.

[0020] Preferably, the moisturizing agent is a compound of glycerin and dipropylene glycol.

[0021] Preferably, the mass ratio of the glycerol to dipropylene glycol is 40-42:20-22.

[0022] By adopting the above technical scheme, the moisturizing effect of the repairing and soothing liposome composition is better through the compounding of glycerol and dipropylene glycol as the moisturizing agents, and it can better lock in moisture, making the skin less likely to dry out, thereby better and faster eliminating skin discomfort and well meeting the needs of consumers.

[0023] Preferably, the antioxidant is a mixture of one or more of pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate), α-tocopherol and totarol.

[0024] Preferably, the antioxidant is pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate).

[0025] By adopting the above technical scheme, using pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamate) ester as an antioxidant, the antioxidant properties of the repairing and soothing liposome composition can be better improved, making it easier for the skin to regain youthfulness and vitality, and the effect of repairing the skin is better.

[0026] In a second aspect, the present application provides a method for preparing a repairing and soothing liposome composition, using the following technical solution: A method for preparing the above-mentioned repairing and soothing liposome composition comprises the following steps: Step 1), mixing the solvent, moisturizer, emulsifier, water-soluble components in the skin conditioner, and Centella asiatica extract, heating to 45-60° C., homogenizing, stirring, and evenly dispersing to obtain an aqueous phase; Step 2), mixing the emollient, kava root extract, the oil-soluble component in the skin conditioner, the roxburghii fruit extract, the ginger root extract, and the antioxidant, heating to 60-85° C., stirring, dispersing evenly, and cooling to 45-60° C. to obtain an oil phase; Step 3), adding the oil phase to the water phase, ultrasonically and homogenizing, emulsifying, and dispersing evenly to obtain colostrum; Step 4), keeping the colostrum warm at 50-65°C, and then treating it with a high-pressure microfluidizer at a pressure of 20,000-35,000 PSI, for 2-8 cycles, cooling it to 50°C, and discharging it to obtain a repairing and soothing liposome composition.

[0027] By adopting the above technical scheme, the prepared repairing and soothing liposome composition has excellent moisturizing, anti-oxidation, soothing, anti-inflammatory and other effects, and is highly safe and suitable for all skin types. Moreover, the repairing and soothing liposome composition has stable quality, can stably exert skin care effects, and has better quality.

[0028] Preferably, the solvent is deionized water.

[0029] By adopting the above technical solution, the skin can be better hydrated and the skin care effect is better.

[0030] In the third aspect, the present application provides an application of a repairing and soothing liposome composition, adopting the following technical scheme: an application of the above-mentioned repairing and soothing liposome composition, wherein the repairing and soothing liposome composition is added to skin care products for preparing skin care products with repairing and soothing effects, and the mass content of the repairing and soothing liposome composition in the skin care products is 0.2-2%.

[0031] By adopting the above technical solution, the manufactured skin care products can quickly relieve skin discomfort, have good moisturizing, anti-oxidation, soothing, anti-inflammatory and other effects, meet the needs of consumers well, and have high economic value.

[0032] In summary, this application has the following beneficial effects: 1. Since the present application adds Centella asiatica extract, Kava root extract, Rosa roxburghii fruit extract, and ginger root extract in a specific proportion, the active ingredients of Centella asiatica extract, Kava root extract, Rosa roxburghii fruit extract, and ginger root extract cooperate with each other to achieve very significant antioxidant and soothing effects, so that the repairing and soothing liposome composition has good effects in moisturizing, anti-oxidation, soothing, and anti-inflammatory aspects, thereby being able to comprehensively repair the skin, restore the skin to health, and quickly eliminate skin discomfort, thus meeting the needs of consumers well.

[0033] 2. In the present application, it is preferred that the skin conditioning agents are compounded with Centella asiatica, Madecassoside, Bisabolol, Stearyl Glycyrrhetinate and Hydroxyphenylpropionamide benzoic acid, so that the repairing and soothing liposome composition has better anti-inflammatory effect, can better and quickly repair the skin, and better meet the needs of consumers for quickly relieving skin discomfort.

[0034] 3. In the present application, the moisturizing agent is preferably a compound of glycerol and dipropylene glycol, so that the moisturizing effect of the repairing and soothing liposome composition is better, which can better lock in moisture and make the skin less likely to dry out, thereby better and faster eliminating skin discomfort and well meeting the needs of consumers. DETAILED DESCRIPTION

[0035] The present application is further described in detail below with reference to the embodiments.

[0036] Example 1 A repairing and soothing liposome composition, the preparation method is as follows: Step 1), deionized water, glycerol, dipropylene glycol, soy lecithin, asiatica glycoside, madecassoside, and Centella asiatica extract are placed in an emulsifier, heated to 45°C, homogenized at 2000r / min and stirred at 60r / min for 3min to obtain an aqueous phase for standby use.

[0037] Step 2), caprylic / capric triglyceride, squalane, kava root extract, bisabolol, roxburghii fruit extract, ginger root extract, pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamic acid), stearyl glycyrrhetinate, hydroxyphenyl propionamide benzoic acid are put into an oil pan, heated to 60°C, stirred at 60r / min for 5min, cooled to 45°C to obtain an oil phase for standby use.

[0038] Step 3), add the oil phase into the water phase, ultrasonicate at 800W for 5 minutes, and then homogenize and emulsify at 2000r / min for 10 minutes to obtain colostrum.

[0039] Step 4), keeping the colostrum warm at 50°C, and then treating it through a high-pressure microfluidizer at a pressure of 20,000 PSI, with a cycle number of 2 times, cooling it to 50°C, and discharging it to obtain a repairing and soothing liposome composition.

[0040] The source information of each raw material in this example is shown in Table 1.

[0041] The addition amount of each raw material in this example (unit: kg) is shown in Table 2.

[0042] Example 2 A repairing and soothing liposome composition, the preparation method is as follows: Step 1), deionized water, glycerol, dipropylene glycol, soy lecithin, asiatica glycoside, madecassoside, and Centella asiatica extract are placed in an emulsifying pot, heated to 50°C, homogenized at 2000r / min and stirred at 60r / min for 3min to obtain an aqueous phase for standby use.

[0043] Step 2), caprylic / capric triglyceride, squalane, kava root extract, bisabolol, roxburghii fruit extract, ginger root extract, pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamic acid), stearyl glycyrrhetinate, hydroxyphenyl propionamide benzoic acid are put into an oil pan, heated to 70°C, stirred at 60r / min for 5min, cooled to 50°C to obtain an oil phase for standby use.

[0044] Step 3), add the oil phase into the water phase, ultrasonicate at 800W for 5 minutes, and then homogenize and emulsify at 2000r / min for 10 minutes to obtain colostrum.

[0045] Step 4), the colostrum is kept warm at 60°C, and then processed by a high-pressure microfluidizer at a pressure of 25,000 PSI, for 5 cycles, and then cooled to 50°C and discharged to obtain a repairing and soothing liposome composition.

[0046] The source information of each raw material in this example is shown in Table 1.

[0047] The addition amount of each raw material in this example (unit: kg) is shown in Table 2.

[0048] Example 3 A repairing and soothing liposome composition, the preparation method is as follows: Step 1), deionized water, glycerol, dipropylene glycol, soy lecithin, asiatica glycoside, madecassoside, and Centella asiatica extract are placed in an emulsifying pot, heated to 60°C, homogenized at 2000r / min and stirred at 60r / min for 3min to obtain an aqueous phase for standby use.

[0049] Step 2), caprylic / capric triglyceride, squalane, kava root extract, bisabolol, roxburghii fruit extract, ginger root extract, pentaerythritol tetra(di-tert-butyl hydroxyhydrocinnamic acid), stearyl glycyrrhetinate, hydroxyphenyl propionamide benzoic acid are put into an oil pan, heated to 85°C, stirred at 60r / min for 5min, cooled to 60°C to obtain an oil phase for standby use.

[0050] Step 3), add the oil phase into the water phase, ultrasonicate at 800W for 5 minutes, and then homogenize and emulsify at 2000r / min for 10 minutes to obtain colostrum.

[0051] Step 4), the colostrum is kept warm at 65°C, and then processed by a high-pressure microfluidizer at a pressure of 35,000 PSI, for 8 cycles, and then cooled to 50°C and discharged to obtain a repairing and soothing liposome composition.

[0052] The source information of each raw material in this example is shown in Table 1.

[0053] The addition amount of each raw material in this example (unit: kg) is shown in Table 2.

[0054] Table 1. Source information of raw materials Table 2. Addition amount of raw materials (unit: kg) Comparative Example 1 A repairing and soothing liposome composition, compared with Example 2, the only difference is: Replace Centella asiatica extract with an equal amount of chamomile extract.

[0055] Chamomile extract was purchased from Shanxi Zhongnuo Biological, water-soluble, and the extraction ratio was 10:1.

[0056] Comparative Example 2 A repairing and soothing liposome composition, compared with Example 2, the only difference is: Replace the kava root extract with an equal amount of lavender extract.

[0057] Lavender extract from Shaanxi Bolin Biology, water-soluble, extraction ratio 10:1.

[0058] Comparative Example 3 A repairing and soothing liposome composition, compared with Example 2, the only difference is: An equal amount of purslane extract was used to replace the roxburghii fruit extract.

[0059] Purslane extract was purchased from Shaanxi Tianshengyuan Biological, water-soluble, and the extraction ratio was 10:1.

[0060] Comparative Example 4 A repairing and soothing liposome composition, compared with Example 2, the only difference is: Replace ginger root extract with an equal amount of licorice extract.

[0061] Licorice extract was purchased from Xi'an Wuling Biological, water-soluble, and the extraction ratio was 10:1.

[0062] Comparative Example 5 A repairing and soothing liposome composition, compared with Example 2, the only difference is: Replace Centella asiatica extract with an equal amount of chamomile extract.

[0063] Replace the kava root extract with an equal amount of lavender extract.

[0064] An equal amount of purslane extract was used to replace the roxburghii fruit extract.

[0065] Replace ginger root extract with an equal amount of licorice extract.

[0066] Chamomile extract was purchased from Shanxi Zhongnuo Biological, water-soluble, and the extraction ratio was 10:1.

[0067] Lavender extract from Shaanxi Bolin Biology, water-soluble, extraction ratio 10:1.

[0068] Purslane extract was purchased from Shaanxi Tianshengyuan Biological, water-soluble, and the extraction ratio was 10:1.

[0069] Licorice extract was purchased from Xi'an Wuling Biological, water-soluble, and the extraction ratio was 10:1.

[0070] Experiment 1 The hyaluronidase inhibition rate was detected on the test samples prepared from the repairing and soothing liposome compositions of the embodiments and comparative examples.

[0071] Hyaluronidase inhibition rate test method: T / JSRH 003-2023 "Hyaluronidase inhibition method for anti-allergic activity test of cosmetic raw materials" Experiment 2 The test samples prepared from the repairing and soothing liposome compositions of the embodiments and comparative examples were subjected to DPPH free radical scavenging rate detection.

[0072] DPPH free radical scavenging rate test method: T / SHRH 006-2018 "Cosmetic free radical (DPPH) scavenging test method" The preparation method of the test sample of Experiment 1-2 is as follows: Take 2 g of the repairing and soothing liposome composition, 20 g of butylene glycol, and 78 g of deionized water, mix them evenly, and obtain a sample to be tested.

[0073] Butanediol is commercially available, CAS No.: 107-88-0, content: 99%.

[0074] The specific experimental data of Experiment 1-2 are shown in Table 3.

[0075] Table 3 Hyaluronidase inhibition rate (%) DPPH free radical scavenging rate (%) Example 1 51.645 43.454 Example 2 51.998 44.127 Example 3 51.824 43.785 Comparative Example 1 43.546 35.981 Comparative Example 2 43.792 35.243 Comparative Example 3 42.987 35.197 Comparative Example 4 43.245 35.729 Comparative Example 5 42.551 34.685 According to the data comparison of each embodiment and comparative example in Table 3, the hyaluronidase inhibition rate and DPPH free radical scavenging rate of each embodiment are significantly higher than those of each comparative example. It can be seen that the soothing and anti-aging effects of each embodiment are significantly improved, and combined with moisturizing, anti-inflammatory and other effects, it can comprehensively repair the skin and quickly relieve skin discomfort.

[0076] In each comparative example, other extracts are used to replace the Centella asiatica extract, Kava root extract, Rosa roxburghii fruit extract, and ginger root extract in the example alone or in whole. Although they can also have certain soothing and anti-aging effects, the soothing and anti-aging effects are significantly weaker than those in the example. It can be seen that each example uses Centella asiatica extract, Kava root extract, Rosa roxburghii fruit extract, and ginger root extract to be compounded in a specific proportion, which can break through the existing technical level, significantly improve the soothing and anti-aging effects, and make the skin repair effect more significant and faster.

[0077] This specific embodiment is merely an explanation of the present application and is not a limitation of the present application. After reading this specification, those skilled in the art may make modifications to the present embodiment without any creative contribution as needed, but such modifications are protected by the patent law as long as they are within the scope of the claims of the present application.

Claims

1. A repairing and soothing liposome composition, characterized in that: The composition includes the following components in parts by weight: 11.3-21.1 parts of solvent; Moisturizer 55-75 parts; Emulsifier 2-10 parts; Skin conditioning agent 3.6-5.6 parts; Emollient 10-25 parts; 0.2-1 part of antioxidant; Centella asiatica extract 0.2-1 part; Kava root extract 1-5 parts; 0.5-0.7 parts of roxburghii fruit extract; Ginger root extract 0.1-0.7 parts.

2. A repairing and soothing liposome composition according to claim 1, characterized in that: The emollient is a mixture of one or more of caprylic / capric triglyceride, octyldodecanol, squalane, jojoba seed oil, and sunflower seed oil.

3. A repairing and soothing liposome composition according to claim 2, characterized in that: The emulsifier is a mixture of one or more of soybean lecithin, egg yolk lecithin, hydrogenated lecithin, hydroxylated lecithin, phosphatidylcholine, phosphatidyldiethanolamine and cholesterol.

4. A repairing and soothing liposome composition according to claim 3, characterized in that: The skin conditioning agent is a mixture of one or more of asiatica glycoside, madecassoside, bisabolol, stearyl glycyrrhetinate, and hydroxyphenylpropionamide benzoic acid.

5. A repairing and soothing liposome composition according to claim 4, characterized in that: The moisturizing agent is one of 1,3-propylene glycol, 1,3-butylene glycol, glycerol, dipropylene glycol, and 1,2-hexanediol, or a mixture of several of them.

6. A repairing and soothing liposome composition according to claim 5, characterized in that: The antioxidant is a mixture of one or more of pentaerythritol tetrakis (di-tert-butyl hydroxyhydrocinnamate), alpha tocopherol and totarol.

7. A method for preparing the repairing and soothing liposome composition according to any one of claims 1 to 6, characterized in that: The following steps are involved: Step 1), mix the solvent, moisturizer, emulsifier, water-soluble components in the skin conditioner, and Centella asiatica extract, raise the temperature to 45-60°C, homogenize, stir, and evenly disperse to obtain an aqueous phase; Step 2), mix the emollient, kava root extract, the oil-soluble component in the skin conditioner, the roxburghii fruit extract, the ginger root extract, and the antioxidant, raise the temperature to 60-85° C., stir, disperse evenly, and cool to 45-60° C. to obtain an oil phase; Step 3), adding the oil phase to the water phase, ultrasonically and homogenizing to emulsify and disperse evenly to obtain colostrum; Step 4), the colostrum is kept warm at 50-65°C, and then processed by a high-pressure microfluidizer at a pressure of 20,000-35,000 PSI, with a cycle number of 2-8 times, cooled to 50°C, and discharged to obtain a repairing and soothing liposome composition.

8. An application of the repairing and soothing liposome composition according to any one of claims 1 to 6, characterized in that: The repairing and soothing liposome composition is added to skin care products for preparing skin care products with repairing and soothing effects, and the mass content of the repairing and soothing liposome composition in the skin care products is 0.2-2%.

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