Blue copper peptide secondary polishing essence with anti-aging and brightening effects and suitable for sensitive skin and preparation method of blue copper peptide secondary polishing essence

Abstract

The invention relates to the field of cosmetics, in particular to blue copper peptide secondary polishing essence which has anti-aging and brightening effects and is suitable for sensitive skin and a preparation method of the blue copper peptide secondary polishing essence. The blue copper peptide secondary polishing essence is prepared from the following components in percentage by mass: 0.001 to 10 percent of beta-glucan solution, 1 to 10 percent of glycerol, 1 to 8 percent of 1, 2-pentanediol, 0.01 to 0.3 percent of xanthan gum, 0.01 to 0.2 percent of sodium hyaluronate and 0.001 to 0.1 percent of arginine; the preparation comprises the following components in percentage by weight: 0.1-5% of a snake venom-like peptide solution, 0.01-1% of an anti-allergy agent solution, 0.01-5% of a nonapeptide-1 solution, 0.0001-1% of a supramolecular blue copper peptide solution, 0.001-1% of blue copper peptide and the balance of water. According to the formula, all the components achieve a synergistic effect, the anti-aging repairing effect and the brightening effect are improved, meanwhile, the formula is mild, the formula can be suitable for sensitive skin, the product effect is more comprehensive, and therefore the application range of the blue copper peptide product can be widened.

Description

Technical Field

[0001] The present application relates to the field of cosmetics, and in particular to a blue copper peptide single-use essence with anti-aging and brightening effects suitable for sensitive skin and a preparation method thereof. Background Art

[0002] Blue copper peptide can improve the skin's repair ability, promote the synthesis of skin matrix, enhance the regeneration ability of skin cell tissue, and enable the skin to heal quickly when damaged. In addition, blue copper peptide also has the effects of anti-oxidation, promoting collagen regeneration, and assisting wound healing. It is suitable for people with dehydrated, dry, and rough skin. It can also reduce the generation of free radicals, avoid premature aging of the skin, promote collagen regeneration, repair damaged skin barriers, and improve damaged skin. Blue copper peptide can also stimulate hair follicles, enhance hair follicle activity, promote hair growth, and reduce the degree of hair loss.

[0003] However, the current blue copper peptide products have a single efficacy and a limited range of applications, and need further development. Summary of the invention

[0004] The purpose of the embodiments of the present application is to provide a new blue copper peptide single-disposable essence with anti-aging and brightening effects suitable for sensitive skin and a preparation method thereof.

[0005] In a first aspect, the present application provides a blue copper peptide single-use essence suitable for sensitive skin with anti-aging and brightening effects. In terms of mass percentage, the blue copper peptide single-use essence comprises:

[0006] 0.001%-10% β-glucan solution, 1%-10% glycerol, 1%-8% 1,2-pentanediol, 0.01%-0.3% xanthan gum, 0.01%-0.2% sodium hyaluronate, 0.001%-0.1% arginine; 0.1%-5% snake venom peptide solution, 0.01%-1% anti-allergic agent solution, 0.01%-5% nonapeptide-1 solution, 0.0001%-1% supramolecular blue copper peptide solution, 0.001%-1% blue copper peptide and the balance water.

[0007] In the above technical solution, the various ingredients of the blue copper peptide single-use essence work together to achieve a synergistic effect, thereby improving the anti-aging and repair effects and brightening effects. In addition, the formula is mild and can be suitable for sensitive skin. The product has more comprehensive effects, thereby expanding the application range of blue copper peptide products.

[0008] In other embodiments of the present application, the β-glucan solution comprises: β-glucan, 1,2-pentanediol and water.

[0009] In other embodiments of the present application, the snake venom peptide solution includes: dipeptide diaminobutyryl benzylamide diacetate, glycerol and water.

[0010] In other embodiments of the present application, the anti-allergic agent solution includes: butylene glycol, 1,2-pentanediol, hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate.

[0011] In other embodiments of the present application, the nonapeptide-1 solution includes: nonapeptide-1, ethylhexylglycerol, 1,2-hexanediol and water.

[0012] In other embodiments of the present application, the supramolecular blue copper peptide solution includes: water, betaine, tartaric acid, 1,2-pentanediol and tripeptide-1 copper.

[0013] In other embodiments of the present application, the blue copper peptide single-use essence comprises, by mass percentage:

[0014] 5%-10% β-glucan solution, 5%-10% glycerol, 1%-8% 1,2-pentanediol, 0.01%-0.3% xanthan gum, 0.01%-0.2% sodium hyaluronate, 0.001%-0.1% arginine; 4%-5% snake venom peptide solution, 0.3%-1% anti-allergic agent solution, 1%-5% nonapeptide-1 solution, 0.5%-1% supramolecular blue copper peptide solution, 0.001%-1% blue copper peptide and the balance water;

[0015] In other embodiments of the present application, the pH value of the blue copper peptide single-use essence is 6.0-7.0.

[0016] In a second aspect, the present application provides a method for preparing a blue copper peptide single-use essence suitable for sensitive skin with anti-aging and brightening effects, the blue copper peptide single-use essence comprising:

[0017] Phase A: the balance of pure water, 0.001%-10% β-glucan solution, 1%-10% glycerol, 1%-8% 1,2-pentanediol, 0.01%-0.3% xanthan gum, 0.01%-0.2% sodium hyaluronate, 0.001%-0.1% arginine;

[0018] Phase B: 0.1%-5% snake venom peptide solution, 0.01%-1% anti-allergic agent solution, 0.01%-5% nonapeptide-1 solution, 0.0001%-1% supramolecular blue copper peptide solution, 0.001%-1% blue copper peptide;

[0019] The preparation method comprises:

[0020] Add the raw materials in phase A into the water phase pot, stir, heat and keep warm to obtain a water phase mixture;

[0021] The water phase mixture is pumped into an emulsifying pot, stirred and heated, vacuumed and homogenized, and kept warm; then the temperature is lowered, the various raw materials in phase B are added, and stirred evenly.

[0022] In other embodiments of the present application, each raw material in phase A is added to a water phase pot, stirred, heated and kept warm, including:

[0023] Add all the raw materials in phase A into the water phase pot, stir at a stirring speed of (500-1500) rpm, heat to (80-90) °C and keep warm for (5-15) min.

[0024] In other embodiments of the present application, the aqueous phase mixture is pumped into an emulsifying pot, stirred and heated, vacuumed and homogenized, and kept warm; then cooled and added to the various raw materials in phase B and stirred evenly, including:

[0025] The aqueous phase mixture was pumped into an emulsifier and heated to (80-90)°C at (20-60) rpm with stirring; the mixture was evacuated to -(0.05±0.02) MPa, and then homogenized at (500-2000) rpm for (1-5) min; the mixture was kept warm for (10-30) min; the mixture was then cooled to (40-50)°C, the raw materials in phase B were added, and the mixture was stirred for (10-20) min. DETAILED DESCRIPTION

[0026] In order to make the purpose, technical solutions and advantages of the embodiments of the present application clearer, the technical solutions in the embodiments of the present application will be clearly and completely described below. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments.

[0027] Therefore, the following detailed description of the embodiments of the present application is not intended to limit the scope of the present application for protection, but merely represents selected embodiments of the present application. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present application.

[0028] Copper is a trace element required to maintain body functions. It has many and complex functions and is an element required for the action of various cell enzymes. In terms of the role of skin tissue, it has the functions of anti-oxidation, promoting collagen proliferation, and assisting wound healing. Scientists have discovered that the wrinkle-removing effect of copper is mainly through the carrier of amino acid complex (peptide), which allows the divalent copper ion components with biochemical effects to enter cells and play a physiological function. Copper-bonded amino acid GHK-CU is a complex composed of three amino acids and one copper ion discovered by scientists from serum. This blue copper peptide can effectively promote the production of collagen and elastin, increase blood vessel growth and antioxidant capacity, and stimulate the production of glucosamine (GAGs), helping the skin to restore its natural ability to repair itself. GHK-CU can increase cell vitality without hurting or irritating the skin, gradually repair the lost collagen in the body, make the subcutaneous tissue strong, and heal the wound quickly, thereby achieving the purpose of wrinkle removal and anti-aging. The composition of GHK-Cu is: glycyl-L-histidyl-L-lysine-copper. Copper ions are not yellow like copper metal, but appear blue in aqueous solution, so GHK-Cu is also called blue copper peptide.

[0029] However, the skin's absorption of this blue copper peptide is limited, and the effectiveness of blue copper peptide products needs to be further improved.

[0030] The present application embodiment provides a blue copper peptide single-use essence liquid with anti-aging and brightening effects suitable for sensitive skin. In terms of mass percentage, the blue copper peptide single-use essence liquid comprises:

[0031] 0.001%-10% β-glucan solution, 1%-10% glycerol, 1%-8% 1,2-pentanediol, 0.01%-0.3% xanthan gum, 0.01%-0.2% sodium hyaluronate, 0.001%-0.1% arginine; 0.1%-5% snake venom peptide solution, 0.01%-1% anti-allergic agent solution, 0.01%-5% nonapeptide-1 solution, 0.0001%-1% supramolecular blue copper peptide solution, 0.001%-1% blue copper peptide and the balance water.

[0032] In the above technical solution, the various ingredients of the blue copper peptide single-use essence work together to achieve a synergistic effect, thereby improving the anti-aging and repair effects and brightening effects. In addition, the formula is mild and can be suitable for sensitive skin. The product has more comprehensive effects, thereby expanding the application range of blue copper peptide products.

[0033] Further, in some embodiments of the present application, the blue copper peptide single-use essence comprises, by mass percentage:

[0034] 0.001%, 0.005%, 0.01%, 0.05%, 0.1%, 0.2%, 0.5%, 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10% or a range between any two of the foregoing β-glucan solution; 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 5%, 6%, 7%, 8%, 9%, 10% or a range between any two of the foregoing glycerol; 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5%, 5.5%, 6%, 6.5%, 7%, 7.5%, 8% or a range between any two of the foregoing 1,2-pentanediol; 0.01%, 0.02%, 0.03%, 0.05%, 0.08%, 0.1%, 0.15%, 0.2%, 0.25%, 0.28%, 0.3% or the range between any two of the above values ​​of xanthan gum; 0.01%, 0.02%, 0.05%, 0.1%, 0.12%, 0.15%, 0.18%, 0.19%, 0.2% or the range between any two of the above values ​​of sodium hyaluronate; 0.001%, 0.002%, 0.005%, 0.01%, 0.02%, 0.03%, 0.04%, 0.05%, 0.06%, 0.07%, 0.08%, 0.09%, 0.1% or any two of the above values arginine in a content range between 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5% or a range between any two of the foregoing snake venom peptide solution; 0.01%, 0.02%, 0.03%, 0.05%, 0.1%, 0.15%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1% or a range between any two of the foregoing antiallergic agent solution; 0.01%, 0.02%, 0.03%, 0.05%, 0.1%, 0.15%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1% or a range between any two of the foregoing 0.08%, 0.1%, 0.2%, 0.3%, 0.5%, 0.8%, 1%, 1.5%, 2%, 2.5%, 3%, 3.5%, 4%, 4.5%, 5% or a range between any two of the foregoing nonapeptide-1 solution; 0.0001%, 0.0002%, 0.0005%, 0.001%, 0.002%, 0.005%, 0.01%, 0.05%, 0.08%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1% or a range between any two of the foregoing supramolecular blue copper peptide solution; 0.001%, 0.005%, 0.01%, 0.0.02%, 0.05%, 0.08%, 0.1%, 0.2%, 0.3%, 0.4%, 0.5%, 0.6%, 0.7%, 0.8%, 0.9%, 1% or the range between any two of the above values ​​of blue copper peptide and the balance water.

[0035] In the above technical scheme, the β-glucan solution is compounded with the snake venom peptide solution to achieve a synergistic effect and improve the anti-aging effect; the nonapeptide-1 solution is compounded with the supramolecular blue copper peptide solution to further improve the absorption effect of the blue copper peptide product and improve the repair, anti-aging and brightening effects.

[0036] Furthermore, in some embodiments of the present application, in the above technical solution, an anti-allergic agent solution is compounded in the blue copper peptide product, and the entire formula is milder, which can effectively enhance the anti-allergic effect of the entire formula and further improve the scope of application of the entire formula, so that it can be suitable for sensitive skin.

[0037] Furthermore, in some embodiments of the present application, in the above technical solution, the blue copper peptide product is a disposable essence, which can further protect the activity of the blue copper peptide product, further facilitate skin absorption, and further facilitate the improvement of anti-aging and brightening effects. In addition, the disposable product is easy to use and has a simple manufacturing process.

[0038] Furthermore, in some embodiments of the present application, the above-mentioned β-glucan solution comprises: β-glucan, 1,2-pentanediol and water.

[0039] For example, in some embodiments of the present application, the β-glucan solution is a mixture of β-glucan, 1,2-pentanediol and water. Optionally, the mass percentage of β-glucan in the mixture is 0.25%.

[0040] The above-mentioned β-glucan solution is more conducive to maintaining activity and is more conducive to compounding in blue copper peptide products. The β-glucan solution has moisturizing, anti-inflammatory and anti-aging effects. It synergizes with other ingredients to further enhance the repair and anti-aging effects of the entire blue copper peptide single-use essence.

[0041] Furthermore, in some embodiments of the present application, the snake venom peptide solution comprises: dipeptide diaminobutyryl benzylamide diacetate, glycerol and water.

[0042] For example, in some embodiments of the present application, the snake venom peptide solution is a mixture of dipeptide diaminobutyryl benzylamide diacetate, glycerol and water. Optionally, the mass percentage of dipeptide diaminobutyryl benzylamide diacetate in the mixture is 0.25%.

[0043] The above-mentioned snake venom peptide solution is more conducive to maintaining activity and is more conducive to compounding in blue copper peptide products. The snake venom peptide solution has anti-inflammatory, wound healing, anti-wrinkle and anti-aging effects. The above-mentioned technical solution can further improve the repair and anti-aging effect of the entire blue copper peptide single-use essence by synergizing the snake venom peptide solution with other ingredients.

[0044] Further, in some embodiments of the present application, the anti-allergic agent solution includes: butylene glycol, 1,2-pentanediol, hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate.

[0045] For example, in some embodiments of the present application, the anti-allergic agent solution is a mixture of butylene glycol, 1,2-pentanediol, hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate. Optionally, the total mass percentage of hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate in the mixture is 5.1%, and the compounding ratio is 5:0.1.

[0046] The above anti-allergic agent solution is more conducive to maintaining activity and is more conducive to compounding in blue copper peptide products. Hydroxyphenylpropionamide benzoic acid has a soothing and anti-allergic effect, and ascorbyl palmitate has an antioxidant, moisturizing, and anti-aging effect. Through compounding, the formula can be made mild, and the repair and anti-aging effects can be synergistically improved, as well as the brightening effect can be improved.

[0047] Further, in some embodiments of the present application, the nonapeptide-1 solution comprises: nonapeptide-1, ethylhexylglycerol, 1,2-hexanediol and water.

[0048] For example, in some embodiments of the present application, the nonapeptide-1 solution is a mixture of nonapeptide-1, ethylhexylglycerol, 1,2-hexanediol and water. Optionally, the mass percentage of nonapeptide-1 in the mixture is 0.1%.

[0049] The above-mentioned nonapeptide-1 solution is more conducive to maintaining activity; it is more conducive to compounding in blue copper peptide products. Nonapeptide-1 has the effects of anti-oxidation, scavenging oxygen free radicals in the skin, and brightening the skin. By compounding it with other ingredients for synergistic enhancement, a synergistic effect can be achieved, which can further enhance the brightening effect of the entire blue copper peptide single-use essence.

[0050] Furthermore, in some embodiments of the present application, the supramolecular blue copper peptide solution comprises: water, betaine, tartaric acid, 1,2-pentanediol and tripeptide-1 copper.

[0051] Illustratively, in some embodiments of the present application, the supramolecular blue copper peptide solution is a mixture of water, betaine, tartaric acid, 1,2-pentanediol and tripeptide-1 copper.

[0052] Further optionally, in some embodiments of the present application, the supramolecular blue copper peptide solution is composed of, by mass percentage, the balance water, 5% betaine, 0.3% tartaric acid, 3%-10% 1,2-pentanediol and 1% tripeptide-1 copper.

[0053] Exemplarily, in terms of mass percentage, the supramolecular blue copper peptide solution is: balance water, 5% betaine, 0.3% tartaric acid; 3%, 4%, 5%, 6%, 7%, 8%, 9% or 10% 1,2-pentanediol and 1% tripeptide-1 copper.

[0054] The supramolecular blue copper peptide solution has good skin penetration promoting effect, and is safe and mild, so that the active molecule of tripeptide-1 copper is more efficiently delivered to the skin; it is more conducive to skin absorption; it is more conducive to compounding in blue copper peptide products. The supramolecular blue copper peptide solution can be compounded with other ingredients to achieve a synergistic effect, further improving the repair, anti-aging and brightening effect of the entire essence.

[0055] Further, in some embodiments of the present application, the blue copper peptide single-use essence comprises, by mass percentage:

[0056] 5%-10% β-glucan solution, 5%-10% glycerol, 1%-8% 1,2-pentanediol, 0.01%-0.3% xanthan gum, 0.01%-0.2% sodium hyaluronate, 0.001%-0.1% arginine; 4%-5% snake venom peptide solution, 0.3%-1% anti-allergic agent solution, 1%-5% nonapeptide-1 solution, 0.5%-1% supramolecular blue copper peptide solution, 0.001%-1% blue copper peptide and the rest water.

[0057] Furthermore, in some embodiments of the present application, the pH value of the blue copper peptide single-use essence is 6.0-7.0.

[0058] In the above technical solution, the pH value of the blue copper peptide single-use essence is 6.0-7.0, which makes the blue copper peptide essence more gentle and suitable for sensitive skin, which is beneficial to the scope of application.

[0059] The present application provides a method for preparing a blue copper peptide single-use essence with anti-aging and brightening effects suitable for sensitive skin, comprising:

[0060] Blue Copper Peptide Single-Use Essence includes:

[0061] Phase A: the balance of pure water, 0.001%-10% β-glucan solution, 1%-10% glycerol, 1%-8% 1,2-pentanediol, 0.01%-0.3% xanthan gum, 0.01%-0.2% sodium hyaluronate, 0.001%-0.1% arginine;

[0062] Phase B: 0.1%-5% snake venom peptide solution, 0.01%-1% anti-allergic agent solution, 0.01%-5% nonapeptide-1 solution, 0.0001%-1% supramolecular blue copper peptide solution, 0.001%-1% blue copper peptide;

[0063] The preparation method comprises:

[0064] Add the raw materials in phase A into the water phase pot, stir, heat and keep warm to obtain a water phase mixture;

[0065] The water phase mixture is pumped into an emulsifying pot, stirred and heated, vacuumed and homogenized, and kept warm; then the temperature is lowered, the various raw materials in phase B are added, and stirred evenly.

[0066] Further, in some embodiments of the present application, each raw material in phase A is added to a water phase pot, stirred, heated and kept warm, including:

[0067] Add all the raw materials in phase A into the water phase pot, stir at a stirring speed of (500-1500) rpm, heat to (80-90) °C and keep warm for (5-15) min.

[0068] For example, in some embodiments of the present application, each raw material in phase A is added to a water phase pot, stirred, heated and kept warm, including:

[0069] Add all the raw materials in phase A into the water phase pot, stir at a stirring speed of (500-1500) rpm, heat to (80-90) °C and keep warm for (5-15) min.

[0070] For example, in some embodiments of the present application, each raw material in phase A is added to the water phase pot, and the stirring speed is 500rpm, 510rpm, 520rpm, 530rpm, 540rpm, 550rpm, 560rpm, 600rpm, 650rpm, 700rpm, 750rpm, 800rpm, 850rpm, 900rpm, 950rpm, 1000rpm, 1100rpm, 1200rpm, 1300rpm, 1400rpm, The mixture is stirred at a speed of 1500 rpm, 1500 rpm or a range between any two of the aforementioned values, and heated to a temperature of 80°C, 81°C, 82°C, 83°C, 84°C, 85°C, 86°C, 87°C, 88°C, 89°C, 90°C or a range between any two of the aforementioned values ​​and kept warm for 5 min, 6 min, 7 min, 8 min, 9 min, 10 min, 11 min, 12 min, 13 min, 14 min, 15 min or a range between any two of the aforementioned values.

[0071] Further, in some embodiments of the present application, the aqueous phase mixture is pumped into an emulsifying pot for stirring and heating, vacuuming and homogenizing, and keeping warm; then the temperature is lowered, the various raw materials in phase B are added, and stirred evenly, including:

[0072] The aqueous phase mixture was pumped into an emulsifier and heated to (80-90)°C at (20-60) rpm with stirring; the mixture was evacuated to -(0.05±0.02) MPa, and then homogenized at (500-2000) rpm for (1-5) min; the mixture was kept warm for (10-30) min; the mixture was then cooled to (40-50)°C, the raw materials in phase B were added, and the mixture was stirred for (10-20) min.

[0073] For example, in some embodiments of the present application, the aqueous phase mixture is pumped into an emulsifying pot, stirred and heated, vacuumed and homogenized, and kept warm; then the temperature is lowered, the various raw materials in phase B are added, and stirred evenly, including:

[0074] The aqueous phase mixture is pumped into an emulsifying pot and stirred and heated at a speed of 20rpm, 25rpm, 30rpm, 35rpm, 40rpm, 45rpm, 50rpm, 55rpm, 60rpm or a range between any two of the aforementioned values ​​to a temperature of 80°C, 81°C, 82°C, 83°C, 84°C, 85°C, 86°C, 87°C, 88°C, 90°C or a range between any two of the aforementioned values; vacuum is evacuated to a pressure of -0.03Mpa, -0.04Mpa, -0.05Mpa, -0.06Mpa, -0.07Mpa or a range between any two of the aforementioned values; then at 500rpm, 600rpm, 700rpm, 800rpm, 900rpm, 1000rpm, 1100rpm, 1200rpm, 1300rpm, 1400rpm, 1500rpm, 1600rpm, The mixture is homogenized at a speed of 1700 rpm, 1800 rpm, 1900 rpm, 2000 rpm or a range between any two of the aforementioned values ​​for 1 min, 2 min, 3 min, 4 min, 5 min or a range between any two of the aforementioned values; and kept warm for 10 min, 15 min, 20 min, 25 min, 30 min or a range between any two of the aforementioned values; then the temperature is reduced to 40°C, 41°C, 42°C, 43°C, 44°C, 45°C, 46°C, 47°C, 48°C, 49°C, 50°C or a temperature within a range between any two of the aforementioned values, and the raw materials in phase B are added and stirred for 10 min, 11 min, 12 min, 13 min, 14 min, 15 min, 16 min, 17 min, 18 min, 19 min, 20 min or a range between any two of the aforementioned values.

[0075] The features and performance of the present application are further described in detail below in conjunction with the embodiments and comparative examples:

[0076] Provided is a blue copper peptide single-disposable essence with anti-aging and brightening effects suitable for sensitive skin, and the formula composition of each embodiment and comparative example is shown in Table 1. The unit in Table 1 is mass percentage.

[0077] Table 1

[0078]

[0079]

[0080] In Table 1: in raw material No. 2, the mass percentage of β-glucan is 0.25%; in raw material No. 8, the mass percentage of dipeptide diaminobutyryl benzylamide diacetate is 0.25%; in raw material No. 9, the total mass percentage of hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate is 5.1%, and the compounding ratio is 5:0.1; in raw material No. 10, the mass percentage of nonapeptide-1 is 0.1%; in raw material No. 11, in terms of mass percentage, the supramolecular blue copper peptide solution is: balance water, 5% betaine, 0.3% tartaric acid, 10% 1,2-pentanediol and 1% tripeptide-1 copper.

[0081] The preparation process is as follows:

[0082] S1. Add the raw materials of phase A into the water phase pot according to the above table, start stirring, heat to 85°C at a stirring speed of 800 rpm, and keep warm for 10 minutes to obtain an aqueous phase mixture;

[0083] S2. The aqueous phase mixture obtained in step S1 is pumped into an emulsifying pot, and stirring is started at a speed of 50 rpm; the temperature is raised to 85°C, and the vacuum is drawn to -0.02 Mpa and homogenized for 5 minutes at a speed of 1000 rpm; the temperature is kept for 20 minutes; the temperature is lowered to 45°C; phase B is added and stirred for 15 minutes and stirred evenly; the material is filtered with a 500-mesh filter cloth to obtain a blue copper peptide single-use essence with anti-aging and brightening effects suitable for sensitive skin.

[0084] The single-use essence has the appearance of a dark blue transparent liquid, has negligible viscosity, and has a pH value of 6.0-7.0.

[0085] Performance Testing

[0086] 1. Test methods

[0087] 80 volunteers with dry, rough, red and loose facial skin, sensitive skin as shown by the sensitive skin self-assessment questionnaire test results and certain skin damage were selected, and they were randomly divided into 8 groups. A before-and-after control experiment was set up, and the skin stratum corneum moisture content, skin gloss, skin elasticity R2 value, skin firmness F4 value, skin transepidermal water loss, skin a* value, skin hemoglobin content, and skin ITA value were collected through non-invasive testing method.

[0088] 2. Product Usage

[0089] Application area: face

[0090] How to use: After cleansing in the morning and evening, use about 1.2ml of essence in the palm of your hand, apply evenly on the face, and gently massage until absorbed.

[0091] Use period: 28 days

[0092] 3. Selection criteria for trial participants

[0093] Women aged 25 to 50, in good health;

[0094] People whose skin is sensitive and whose skin barrier is damaged to a certain extent are shown in the sensitive skin self-assessment questionnaire test results;

[0095] TEWL value of the test part ≥15g / (h·㎡)

[0096] 4. Test equipment

[0097] Facial image photography and analysis system VISTA-CR (Canfield, USA)

[0098] Corneometer CM 825 (Courage & Khazaka, Germany)

[0099] Glossymeter GL 200 (Courage & Khazaka, Germany)

[0100] Skin elasticity tester Cutometer MPA580 (Courage & Khazaka, Germany)

[0101] Skin-Colorimeter CL 400 (Courage & Khazaka, Germany)

[0102] Skin pigment test probe Mexamter MX l 8 (Courage&Khazaka, Germany)

[0103] Skin water loss meter AquafluxAF200 (BIOX, UK)

[0104] 5. See Table 2 for details of the test contents.

[0105] Table 2

[0106]

[0107] The test results of various embodiments and comparative examples are shown in Table 3.

[0108] Table 3

[0109]

[0110]

[0111] From the experimental data in Table 3 above, we can see that:

[0112] The change rate of moisture content in the stratum corneum and the change rate of transepidermal water loss of the skin in each embodiment are higher than those in each comparative example, indicating that the scheme of the embodiment can effectively improve the skin repair effect; the change rate of skin elasticity R2 value in each embodiment is higher than that of skin elasticity R2 value in each comparative example, indicating that the scheme of the embodiment can effectively improve skin elasticity and has an effective anti-aging effect. The change rate of skin a* value and the change rate of skin hemoglobin content in each embodiment are higher than those of skin a* value and skin hemoglobin content in each comparative example, indicating that the scheme of the embodiment can effectively brighten the skin. This test shows that after using the sample, the reaction score level of 60 sensitive skin subjects was 0, and no adverse reactions or adverse events occurred, so the product is suitable for sensitive skin.

[0113] In summary, the solutions of the embodiments of the present application can effectively achieve the effects of repair, anti-aging and brightening, and can be suitable for sensitive skin.

[0114] The above description is only the preferred embodiment of the present application and is not intended to limit the present application. For those skilled in the art, the present application may have various modifications and variations. Any modification, equivalent replacement, improvement, etc. made within the spirit and principle of the present application shall be included in the protection scope of the present application.

Claims

1. A blue copper peptide single-use essence with anti-aging and brightening effects suitable for sensitive skin, characterized in that: In terms of mass percentage, the blue copper peptide single-use essence comprises: 0.001%-10% β-glucan solution, 1%-10% glycerol, 1%-8% 1,2-pentanediol, 0.01%-0.3% xanthan gum, 0.01%-0.2% sodium hyaluronate, 0.001%-0.1% arginine; 0.1%-5% snake venom peptide solution, 0.01%-1% anti-allergic agent solution, 0.01%-5% nonapeptide-1 solution, 0.0001%-1% supramolecular blue copper peptide solution, 0.001%-1% blue copper peptide and the balance water.

2. The blue copper peptide single-use essence with anti-aging and brightening effects suitable for sensitive skin according to claim 1, characterized in that: The β-glucan solution comprises β-glucan, 1,2-pentanediol and water.

3. The blue copper peptide single-use essence with anti-aging and brightening effects suitable for sensitive skin according to claim 1, characterized in that: The snake venom peptide solution comprises dipeptide diaminobutyryl benzylamide diacetate, glycerol and water.

4. The blue copper peptide single-use essence with anti-aging and brightening effects suitable for sensitive skin according to claim 1, characterized in that: The anti-sensitizer solution comprises: butylene glycol, 1,2-pentanediol, hydroxyphenylpropionamide benzoic acid and ascorbyl palmitate.

5. The blue copper peptide single-use essence with anti-aging and brightening effects suitable for sensitive skin according to claim 1, characterized in that: The nonapeptide-1 solution comprises nonapeptide-1, ethylhexylglycerol, 1,2-hexanediol and water.

6. The blue copper peptide single-use essence with anti-aging and brightening effects suitable for sensitive skin according to claim 1, characterized in that: The supramolecular blue copper peptide solution comprises: water, betaine, tartaric acid, 1,2-pentanediol and tripeptide-1 copper.

7. The blue copper peptide single-use essence with anti-aging and brightening effects suitable for sensitive skin according to any one of claims 1 to 6, characterized in that: In terms of mass percentage, the blue copper peptide single-use essence comprises: 5%-10% β-glucan solution, 5%-10% glycerol, 1%-8% 1,2-pentanediol, 0.01%-0.3% xanthan gum, 0.01%-0.2% sodium hyaluronate, 0.001%-0.1% arginine; 4%-5% snake venom peptide solution, 0.3%-1% anti-allergic agent solution, 1%-5% nonapeptide-1 solution, 0.5%-1% supramolecular blue copper peptide solution, 0.001%-1% blue copper peptide and the balance water; Optionally, the pH value of the blue copper peptide single-use essence is 6.0-7.

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8. The method for preparing the blue copper peptide single-use essence with anti-aging and brightening effects suitable for sensitive skin according to any one of claims 1 to 7, characterized in that: The blue copper peptide single-disposable essence comprises: Phase A: the balance of pure water, 0.001%-10% β-glucan solution, 1%-10% glycerol, 1%-8% 1,2-pentanediol, 0.01%-0.3% xanthan gum, 0.01%-0.2% sodium hyaluronate, 0.001%-0.1% arginine; Phase B: 0.1%-5% snake venom peptide solution, 0.01%-1% anti-allergic agent solution, 0.01%-5% nonapeptide-1 solution, 0.0001%-1% supramolecular blue copper peptide solution, 0.001%-1% blue copper peptide; The preparation method comprises: Add the raw materials in phase A into a water phase pot, stir, heat and keep warm to obtain a water phase mixture; The aqueous phase mixture is pumped into an emulsifying pot, stirred and heated, vacuumed and homogenized, and kept warm; then the temperature is lowered, the various raw materials in the phase B are added, and stirred evenly.

9. The method for preparing the blue copper peptide single-use essence with anti-aging and brightening effects suitable for sensitive skin according to any one of claims 1 to 7, characterized in that: The process of adding the raw materials in phase A into a water phase pot, stirring, heating and keeping warm comprises: Add the raw materials in phase A into the water phase pot, stir at a stirring speed of (500-1500) rpm, heat to (80-90)°C and keep warm for (5-15) min.

10. The method for preparing the blue copper peptide single-use essence with anti-aging and brightening effects suitable for sensitive skin according to claim 9, characterized in that: The aqueous phase mixture is pumped into an emulsifying pot for stirring and heating, vacuuming and homogenizing, and keeping warm; Then cool down and add the raw materials in phase B and stir evenly, including: The aqueous phase mixture is pumped into an emulsifier and heated to (80-90)°C at (20-60) rpm with stirring; the mixture is evacuated to -(0.05±0.02) Mpa, and then homogenized at (500-2000) rpm for (1-5) min; the mixture is kept warm for (10-30) min; the mixture is then cooled to (40-50)°C, the raw materials in phase B are added, and the mixture is stirred for (10-20) min.

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