A device for isolating and purifying a podophyllotoxin

Abstract

The present application relates to the technical field of podophyllotoxin extraction, and particularly relates to a podophyllotoxin separation and purification device, which comprises a juice pressing mechanism, and the juice pressing mechanism is used for juice pressing treatment of chopped rhizomes and leaves. In the present application, the pressing root disc rotates in the positioning ring when descending, so that the arc-shaped cutter at the bottom of the pressing root disc can cut the plant rhizomes in two sections when extruding the plant rhizomes, facilitating the re-chopping of the uncut rhizomes, thereby facilitating the improvement of the juice pressing extraction effect of the plant rhizomes. The above operation can simultaneously perform the juice pressing extraction of medicinal juice of the plant leaves and rhizomes of the podophyllum genus, the obtained medicinal liquid can separate the podophyllotoxin through the decocting method, the medicinal liquid obtained through the juice pressing has less impurities, so that the medicinal substances obtained after decocting can be conveniently filtered, the separation speed of the podophyllotoxin is accelerated, and the medicinal substances in the plant leaves and rhizomes can be simultaneously extracted through the juice pressing mechanism, so that the waste of effective medicinal resources is avoided.

Description

Technical Field

[0001] This invention relates to the field of podophyllotoxin extraction technology, specifically a podophyllotoxin separation and purification device. Background Technology

[0002] Podophyllotoxin is a lignan-based antitumor component extracted from the roots and stems of plants in the Podophyllum genus. It is a white crystalline powder, odorless, and hygroscopic. Podophyllotoxin extracted from Podophyllum oxypetalum can be formulated into ointments and tinctures. Podophyllotoxin effectively inhibits herpesviruses and suppresses mitosis during metaphase of cell division, making it useful for treating viral infections. Podophyllotoxin can also inhibit the division and proliferation of epithelial cells caused by human papillomavirus (HPV) infection, leading to necrosis and shedding of infected epithelial cells, thus achieving a therapeutic effect on condyloma acuminata.

[0003] Currently, the isolation and purification of podophyllotoxin mostly involves using plant materials containing podophyllotoxin, such as the rhizomes of Podophyllum hexandrum and Podophyllum occulta. These plant rhizomes are crushed and extracted using organic solvents such as methanol and ethanol. These solvents can dissolve podophyllotoxin and separate it from the plant material. The current method mainly involves grinding the plant roots into powder and then dissolving it with solvents. However, the sap in the flowers and leaves of medicinal plants also contains podophyllotoxin. Current separation and purification equipment cannot simultaneously extract medicinal substances from the rhizomes and flowers and leaves of Podophyllum plants, thus wasting effective medicinal resources. The degree of crushing and drying of the plant rhizomes affects the solubility of the material and solvent. When the moisture content of the powder is too high, it can easily lead to solvent dilution, reducing the extraction rate of medicinal substances from the plant. Summary of the Invention

[0004] The purpose of this invention is to provide a podophyllotoxin separation and purification device to solve the problems mentioned in the background art.

[0005] To achieve the above objectives, the present invention provides the following technical solution: a podophyllotoxin separation and purification device, comprising:

[0006] A chopping centrifuge mechanism for chopping the roots, stems, flowers, and leaves of plants in the genus Podophyllum;

[0007] A juice pressing mechanism is used to press the juice from chopped roots, stems, flowers, and leaves. The juice pressing mechanism includes a fixed ring plate, a mounting bracket fixedly connected to the top of the fixed ring plate, a reciprocating spiral groove on the inner wall of the fixed ring plate, an embedded slider slidably embedded in the reciprocating spiral groove, an L-shaped rod fixedly connected to the end of the embedded slider, a juice pressing ring plate fixedly connected to the bottom end of the L-shaped rod, a limiting cavity opened inside the juice pressing ring plate, a limiting ring rotatably sleeved in the limiting cavity, a sliding rod fixedly connected to the inner wall of the limiting ring, a positioning ring fixedly connected to the end of the sliding rod, a root pressing circular plate rotatably sleeved in the positioning ring, and multiple arc-shaped cutters fixedly connected at equal intervals in a ring at the bottom of the root pressing circular plate.

[0008] A powder drying mechanism is used to crush plant roots and stems into powder and perform a circulating drying process on the powder.

[0009] Furthermore, the chopping and centrifuging mechanism includes a tank body fixedly connected to a mounting frame, a rotating tank rotatably sleeved at the center of the tank body, a filter press plate screwed onto the bottom of the rotating tank, a drain pipe fixedly connected to the bottom of the tank body and communicating with its interior, a support frame fixedly installed on the outside of the tank body, a toothed ring fixedly sleeved on the outer wall of the rotating tank, a spur gear meshing with one side of the toothed ring, an output end of a drive motor fixedly connected at the center of the spur gear, and the drive motor fixedly connected to the inner wall of the tank body.

[0010] Furthermore, the rotating tank has multiple centrifuge shells fixedly connected at equal intervals in a ring inside, and each of the multiple centrifuge shells has a centrifuge filter plate fixedly connected to it.

[0011] Furthermore, multiple blade cutters are fixedly connected at equal intervals on the inner walls of the centrifuge shells, a fixed cylinder is sleeved at the center of the rotating tank, the top of the fixed cylinder is fixedly connected to the bottom of the mounting frame, multiple fixed cutting blades are fixedly connected at equal intervals in a ring on the outer wall of the fixed cylinder, and multiple sweeping blades are fixedly connected at equal intervals in a ring at the bottom of the fixed cylinder.

[0012] Furthermore, a rotating shaft is provided at the center of the fixed cylinder, and multiple root cutting blades are fixedly connected in a ring at equal intervals on the outer wall of the rotating shaft. Multiple fixed cutting blades are fixedly connected in a ring at equal intervals on the inner wall of the fixed cylinder. The output end of a servo motor is fixedly connected to the top of the rotating shaft, and a linkage shaft is fixedly connected to the bottom of the rotating shaft. The root pressing circular plate is slidably sleeved with the linkage shaft.

[0013] Furthermore, two limiting grooves are symmetrically formed on the inner wall of the rotating tank, and the juice pressing ring plate is slidably engaged with the limiting grooves.

[0014] Furthermore, the bottom of the fixed cylinder is fixedly connected to a flared cylinder that communicates with its interior, the pressing circular plate is slidably sleeved with the flared cylinder, the flared cylinder has a vertical groove, the sliding rod is slidably connected with the vertical groove, and the outer wall of the flared cylinder has a plurality of filter holes circumferentially spaced at equal intervals.

[0015] Furthermore, a truncated cone is fixedly fitted onto the outer wall of the flared cylinder.

[0016] Furthermore, the powder drying mechanism includes a connecting cylinder fixedly connected to the bottom end of the flared cylinder, a pulverizing cylinder fixedly connected to the bottom end of the connecting cylinder, a servo motor II fixedly connected to the end of the pulverizing cylinder, a pulverizing blade shaft fixedly connected to the output end of the servo motor II, the output end of a hot air blower fixedly connected to the side wall of the pulverizing cylinder, a circulation pipe fixedly connected to the end of the pulverizing cylinder and communicating with its interior, a powder outlet pipe fixedly connected to the circulation pipe, a solenoid valve I fixedly installed in the powder outlet pipe, and a solenoid valve II fixedly installed in the circulation pipe.

[0017] Furthermore, a sealing block is provided at the top of the connecting cylinder, and two compression springs that are fixedly connected to the inner wall of the connecting cylinder are symmetrically fixedly connected to the bottom of the sealing block.

[0018] Compared with the prior art, the beneficial effects of the present invention are as follows: 1. By putting the rhizome of Podophyllum hexandrum into a fixed cylinder, and its flowers and leaves into the chopping chamber between the fixed cylinder and the rotating tank, the output end of the drive motor drives the spur gear to rotate, thereby driving the gear ring and the rotating tank to rotate. Multiple leaf-cutting blades inside the rotating tank rotate rapidly around the fixed cylinder, so that the leaf-cutting blades and the fixed cutting blade 1 rotate alternately to chop the plant flowers and leaves. At the same time, the output end of the servo motor 1 drives the rotating shaft and the root-cutting blade to rotate, so that multiple root-cutting blades and the fixed cutting blade 2 rotate alternately to cut the plant roots and rhizomes. The juice flowing out during the chopping of flowers and leaves will flow along the surface of the centrifuge shell. The rotating tank will centrifuge the chopped plant flowers and leaves, and then filter the plant juice produced by centrifugation through the centrifuge filter plate. The filtered plant medicinal liquid material will be centrifuged into the tank, which is conducive to the centrifugal extraction of medicinal liquid from the flowers and leaves of Podophyllum hexandrum plants.

[0019] 2. The rotating tank drives the pressing ring plate to rotate synchronously, which in turn drives the embedded slider at the end of the L-shaped rod to slide in the reciprocating spiral groove. Then, the L-shaped rod drives the pressing ring plate to move up and down reciprocally. Since the multiple sweeping blades on the outer wall of the fixed cylinder will rotate relative to the rotating tank, it is convenient to sweep the centrifuged flower and leaf residue between the pressing ring plate and the truncated cone. The flower and leaf residue rolls down along the truncated cone to the top of the filter plate. When the pressing ring plate presses down, it filters the centrifuged flower and leaf residue. The pressed plant liquid drips into the tank through the filter plate. During the descent of the pressing ring plate, the gap between it and the truncated cone gradually decreases. Therefore, on the one hand, it can form a closed condition and improve the compactness during filtration. On the other hand, when the pressing ring plate rises, new flower and leaf residue will be swept back into the pressing space. The reciprocating pressing ring plate can fully extract the medicinal liquid from the flower and leaf residue.

[0020] 3. After the rhizomes of the Podophyllum genus are cut into granules, they fall into the flared cylinder. Because the sap-pressing ring plate has a limiting cavity that restricts the sliding rod, the sliding rod drives the positioning ring to rise and fall synchronously with the sap-pressing ring plate. When the positioning ring descends, it drives the pressing plate to squeeze the rhizomes inside the flared cylinder, thus extracting the medicinal liquid from the Podophyllum genus rhizomes. The liquid is then filtered through filter holes on the outer wall of the flared cylinder. Because the linkage shaft and the pressing plate are slidably connected, the pressing plate also rotates within the positioning ring as it descends. Therefore, the arc-shaped cutter at the bottom of the pressing plate can effectively squeeze the rhizomes... When processing the rhizomes, they are cut into two sections to facilitate further chopping of the uncut rhizomes, thereby improving the extraction efficiency of the plant's rhizomes through pressure filtration. This process allows for the simultaneous extraction of medicinal juices from the flowers, leaves, and rhizomes of Podophyllum plants. The resulting liquid can then be used to separate podophyllotoxins through decoction. Because the pressure-filtered liquid contains fewer impurities, the medicinal substances obtained after decoction are easier to filter, accelerating the separation of podophyllotoxins. The pressure filtration mechanism allows for the simultaneous extraction of medicinal substances from the plant's flowers, leaves, and rhizomes, thus avoiding the waste of effective medicinal resources.

[0021] 4. As the pressure plate descends and approaches the sealing block, the two compression springs gradually contract under pressure, squeezing the granular plant roots and stems from the opening between the sealing block and the connecting cylinder. Then, the servo motor drives the pulverizing blade shaft to rotate rapidly, performing the third step of pulverizing the granular plant roots and stems into powder. Simultaneously, hot air is introduced into the pulverizing cylinder by a hot air blower to dry the root and stem powder. A circulation pipe facilitates the circulation of hot air to dry the powder, quickly removing moisture. The inclined upward end of the circulation pipe allows for the backflow and re-cutting of any roots and stems that have not been completely pulverized or cut under gravity. After drying, solenoid valve two is closed, and solenoid valve one is opened, allowing the dried root and stem powder to be quickly discharged under airflow. The fully dried plant root and stem powder improves the solubility of the powder and solvent when combined with solvents such as methanol or ethanol, thus increasing the amount of podophyllotoxin medicinal material separated from the plant roots and stems. Attached Figure Description

[0022] Figure 1 This is a schematic diagram of the overall structure of the present invention;

[0023] Figure 2 This is a schematic diagram of the overall top view structure of this invention;

[0024] Figure 3 This is a schematic diagram of the internal cross-sectional structure of the tank in this invention;

[0025] Figure 4 This is a schematic diagram of the chopping and centrifuging mechanism in this invention;

[0026] Figure 5 This is a schematic diagram of the fixed cylinder connection structure in this invention;

[0027] Figure 6 This is a schematic diagram of the bottom structure of the rotating tank in this invention;

[0028] Figure 7 This is a schematic diagram of the juice pressing mechanism in this invention;

[0029] Figure 8 This is a schematic diagram of the shaft connection structure in this invention;

[0030] Figure 9 This is a schematic diagram of the internal structure of the flared cylinder in this invention;

[0031] Figure 10 This is a schematic diagram of the powder drying mechanism in this invention;

[0032] Figure 11 This is a schematic diagram of the cross-sectional structure of the crushing cylinder in this invention.

[0033] In the diagram: 100. Chopping and centrifuging mechanism; 101. Tank body; 102. Rotating tank; 103. Support frame; 104. Filter press plate; 105. Gear ring; 106. Spur gear; 107. Drive motor; 108. Centrifuge shell; 109. Centrifuge filter plate; 110. Leaf cutting blade; 111. Fixed cylinder; 112. Fixed cutting blade one; 113. Sweeping blade; 114. Fixed cutting blade two; 115. Limiting groove; 200. Juice pressing mechanism; 201. Fixed ring plate; 202. Mounting frame; 203. Reciprocating spiral groove; 204. Servo motor one; 205. Rotating shaft; 206. Root cutting blade; 207. Linkage 208. Moving shaft; 209. Embedded slider; 210. L-shaped rod; 211. Juice pressing ring plate; 212. Limiting cavity; 213. Slide rod; 214. Positioning ring; 215. Pressing root round plate; 216. Arc-shaped cutter; 217. Flaring cylinder; 218. Filter hole; 219. Vertical groove; 300. Frustum cone; 301. Powder drying mechanism; 302. Connecting cylinder; 303. Crushing cylinder; 304. Servo motor II; 305. Crushing blade shaft; 306. Hot air blower; 307. Circulation pipe; 308. Powder outlet pipe; 309. Solenoid valve I; 310. Solenoid valve II; 311. Sealing round block; 312. Compression spring. Detailed Implementation

[0034] The technical solutions of the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of the present invention, and not all embodiments. Based on the embodiments of the present invention, all other embodiments obtained by those skilled in the art without creative effort are within the scope of protection of the present invention.

[0035] Please see Figure 1-11In this embodiment of the invention, a podophyllotoxin separation and purification device includes: a chopping and centrifuging mechanism 100, a juice pressing mechanism 200, and a powder drying mechanism 300. The chopping and centrifuging mechanism 100 is used to chop the roots, stems, flowers, and leaves of plants of the genus Podophyllum; the juice pressing mechanism 200 is used to press the juice from the chopped roots, stems, flowers, and leaves. The juice pressing mechanism 200 includes a fixed ring plate 201, a mounting bracket 202 fixedly connected to the top of the fixed ring plate 201, and a reciprocating spiral groove 203 formed on the inner wall of the fixed ring plate 201. An embedded slider 208 is slidably embedded in the reciprocating spiral groove 203, and the embedded slider 208 slides in the reciprocating spiral groove 203, allowing the juice to be extracted through the centrifugal force. L-shaped rod 209 drives the juice pressing ring plate 210 to reciprocate up and down. The end of the embedded slider 208 is fixedly connected to the L-shaped rod 209. The bottom end of the L-shaped rod 209 is fixedly connected to the juice pressing ring plate 210. The juice pressing ring plate 210 has a limiting cavity 211 inside. A limiting ring is rotatably sleeved in the limiting cavity 211. A sliding rod 212 is fixedly connected to the inner wall of the limiting ring. A positioning ring 213 is fixedly connected to the end of the sliding rod 212. A root pressing round plate 214 is rotatably sleeved in the positioning ring 213. Multiple arc-shaped cutters 215 are fixedly connected at equal intervals in a ring at the bottom of the root pressing round plate 214. The arc-shaped cutters 215 at the bottom of the root pressing round plate 214 can cut the plant roots in two stages when pressing them.

[0036] A rotating shaft 205 is provided at the center of the fixed cylinder 111, and the outer wall of the rotating shaft 205 is fixedly connected in a ring at equal intervals.

[0037] There are multiple root-cutting blades 206. Multiple fixed-cutting blades 114 are fixedly connected in a ring at equal intervals on the inner wall of the fixed cylinder 111. The output end of the servo motor 204 is fixedly connected to the top of the rotating shaft 205, and the linkage shaft 207 is fixedly connected to the bottom of the rotating shaft 205. The root-pressing circular plate 214 is slidably sleeved with the linkage shaft 207. Two limiting grooves 115 are symmetrically opened on the inner wall of the rotating tank 102, and the pressing ring plate 210 is slidably engaged with the limiting grooves 115. A flared cylinder 216, communicating with the interior of the fixed cylinder 111, is fixedly connected to the bottom of the fixed cylinder 111. A truncated cone 219 is fixedly sleeved on the outer wall of the flared cylinder 216. As the pressing ring plate 210 descends, the gap between it and the truncated cone 219 gradually decreases. Therefore, on the one hand, a closed condition is formed, which improves the compactness during pressing and filtration; on the other hand, when the pressing ring plate 210 rises, new flower and leaf residue will be swept back into the pressing space. The root pressing circular plate 214 is slidably sleeved with the flared cylinder 216. A vertical groove 218 is opened on the flared cylinder 216, and a sliding rod 212 is slidably connected to the vertical groove 218. Multiple filter holes 217 are circumferentially spaced on the outer wall of the flared cylinder 216. The powder drying mechanism 300 is used to crush plant roots and stems into powder and perform circulating drying treatment on the powder.

[0038] Specifically, the rotating tank 102 drives the pressing ring plate 210 to rotate synchronously, thereby causing the embedded slider 208 at the end of the L-shaped rod 209 to slide in the reciprocating spiral groove 203. Then, the L-shaped rod 209 drives the pressing ring plate 210 to reciprocate up and down. Since the multiple sweeping blades 113 on the outer wall of the fixed cylinder 111 will rotate relative to the rotating tank 102, it is convenient to sweep the centrifuged flower and leaf residue between the pressing ring plate 210 and the truncated cone 219. The flower and leaf residue rolls down along the truncated cone 219 to the top of the filter press plate 104. When the pressing ring plate 210 presses down, it pushes the centrifuged flower and leaf residue... The medicinal residue is filtered by pressure, and the pressed herbal liquid drips into the tank 101 through the filter plate 104. As the pressing ring plate 210 descends, the gap between it and the truncated cone 219 gradually decreases. This creates a sealed environment, increasing the compactness of the filtration. Furthermore, when the pressing ring plate 210 rises, new flower and leaf residue is swept back into the pressing space. The reciprocating lifting and lowering of the pressing ring plate 210 ensures thorough extraction of the medicinal liquid from the flower and leaf residue. The rhizomes of the Podophyllum species are cut into granules and fall into the flared cylinder 216. Due to the limiting mechanism inside the pressing ring plate 210... Cavity 211 restricts slide bar 212, thereby allowing slide bar 212 to drive positioning ring 213 to rise and fall synchronously with juicing ring plate 210. When positioning ring 213 descends, it drives root pressing round plate 214 to squeeze the rhizome inside flared cylinder 216, thereby squeezing out the medicinal liquid from the rhizome of Podophyllum. The medicinal liquid is filtered through filter holes 217 on the outer wall of flared cylinder 216. Since linkage shaft 207 and root pressing round plate 214 are slidably connected, root pressing round plate 214 also rotates in positioning ring 213 when it descends. Therefore, the arc-shaped cutter 215 at the bottom of root pressing round plate 214 can... When pressing plant roots and stems, a two-stage cutting process is performed to facilitate the further chopping of any uncut parts, thereby improving the extraction efficiency of the plant root and stem juice. Through this operation, the medicinal juice of the flowers, leaves, and roots and stems of Podophyllum plants can be extracted simultaneously by pressure filtration. The resulting liquid can be used to separate podophyllotoxin through decoction. Because the liquid obtained by pressure filtration contains fewer impurities, the medicinal substances obtained after decoction are easier to filter, accelerating the separation speed of podophyllotoxin. The juice pressing mechanism 200 can simultaneously extract medicinal substances from the flowers, leaves, and roots and stems of plants, thus avoiding the waste of effective medicinal resources. Example 1

[0039] like Figure 4-6As shown, in this embodiment, the chopping and centrifuging mechanism 100 includes a tank 101 fixedly connected to the mounting frame 202. A rotating tank 102 is rotatably sleeved at the center of the tank 101. A filter plate 104 is screwed onto the bottom of the rotating tank 102. A drain pipe communicating with the interior of the tank 101 is fixedly connected to the bottom of the tank 101. A support frame 103 is fixedly installed on the outside of the tank 101. A toothed ring 105 is fixedly sleeved on the outer wall of the rotating tank 102. A spur gear 106 is meshed with one side of the toothed ring 105. The output end of a drive motor 107 is fixedly connected at the center of the spur gear 106. The drive motor 107 is fixedly connected to the inner wall of the tank 101. Multiple centrifuge shells 108 are fixedly connected in a ring at equal intervals inside the rotating tank 102. Centrifuge filter plates 109 are fixedly connected in each of the multiple centrifuge shells 108. Multiple leaf-cutting blades 110 are fixedly connected at equal intervals on the inner walls of multiple centrifuge shells 108. When the leaf-cutting blades 110 and the fixed-cutting blades 112 rotate and alternate, they chop the plant flowers and leaves. A fixed cylinder 111 is sleeved at the center of the rotating tank 102. The top of the fixed cylinder 111 is fixedly connected to the bottom of the mounting frame 202. Multiple fixed-cutting blades 112 are fixedly connected at equal intervals in a ring on the outer wall of the fixed cylinder 111. Multiple sweeping blades 113 are fixedly connected at equal intervals in a ring at the bottom of the fixed cylinder 111. The multiple sweeping blades 113 on the outer wall of the fixed cylinder 111 will rotate relative to the rotating tank 102, which makes it easier to sweep the centrifuged flower and leaf residue between the pressing ring plate 210 and the truncated cone 219.

[0040] In this embodiment, the rhizomes of *Polygonum aviculare* are placed into the fixed cylinder 111, while the flowers and leaves are placed into the chopping chamber between the fixed cylinder 111 and the rotating tank 102. The output of the drive motor 107 drives the spur gear 106 to rotate, thereby rotating the gear ring 105 and the rotating tank 102. Multiple leaf-cutting blades 110 inside the rotating tank 102 rotate rapidly around the fixed cylinder 111, causing the leaf-cutting blades 110 and the fixed cutting blade 112 to alternate rotations and chop the plant flowers and leaves. Simultaneously, the servo motor 2... The output end drives the rotating shaft 205 and the root cutting blade 206 to rotate, so that multiple root cutting blades 206 and fixed cutting blade 114 rotate and interweave to cut the plant roots and stems. The juice flowing out during the chopping of flowers and leaves will flow along the surface of the centrifuge shell 108. The chopped plant flowers and leaves will be centrifuged through the rotating tank 102. Then, the plant juice produced by centrifugation will be filtered through the centrifuge filter plate 109. The filtered plant medicinal liquid material will be centrifuged into the tank 101, which is conducive to the centrifugal extraction of medicinal liquid from the flowers and leaves of Podophyllum plants. Example 2

[0041] like Figure 10-11As shown, in this embodiment, the powder drying mechanism 300 includes a connecting cylinder 301 fixedly connected to the bottom end of the flared cylinder 216, a pulverizing cylinder 302 fixedly connected to the bottom end of the connecting cylinder 301, a servo motor 303 fixedly connected to the end of the pulverizing cylinder 302, a pulverizing blade shaft 304 fixedly connected to the output end of the servo motor 303, an output end of a hot air blower 305 fixedly connected to the side wall of the pulverizing cylinder 302, and a circulation pipe 306 connected to the end of the pulverizing cylinder 302 and communicating with its interior. The root powder is dried using hot air. The circulation pipe 306 facilitates the circulation of hot air to dry the powder. A powder outlet pipe 307 is fixedly connected to the circulation pipe 306, a solenoid valve 308 is fixedly installed in the powder outlet pipe 307, and a solenoid valve 309 is fixedly installed in the circulation pipe 306. The top of the connecting cylinder 301 is provided with a sealing block 310. Two compression springs 311 that are fixedly connected to the inner wall of the connecting cylinder 301 are symmetrically fixed to the bottom of the sealing block 310. Under the action of pressure, the two compression springs 311 gradually contract, and then the granular plant roots can be squeezed down from the opening between the sealing block 310 and the connecting cylinder 301.

[0042] In practice, as the pressing disc 214 descends and gradually approaches the sealing disc 310, the two compression springs 311 gradually contract under pressure, squeezing the granular plant roots and stems from the opening between the sealing disc 310 and the connecting cylinder 301. Then, the servo motor 303 drives the pulverizing blade shaft 304 to rotate rapidly, performing a third step of pulverizing the granular plant roots and stems, thus breaking them into powder. Simultaneously, a hot air blower 305 introduces hot air into the pulverizing cylinder 302, drying the root powder. This process is achieved by... The circulation pipe 306 facilitates the circulation of hot air to dry the powder, thereby quickly removing moisture from the powder. The inclined upward end of the circulation pipe 306 allows for the backflow and re-cutting of incompletely crushed or cut roots and stems under the action of gravity. After drying, the second solenoid valve 309 is closed, and the first solenoid valve 308 is opened, allowing the dried root and stem powder to be quickly discharged under the action of airflow. The fully dried plant root and stem powder can improve the dissolution effect of the powder and solvent when combined with solvents such as methanol or ethanol, thus facilitating the increase of the separation amount of podophyllotoxin medicinal material in plant roots and stems.

[0043] It will be apparent to those skilled in the art that the present invention is not limited to the details of the exemplary embodiments described above, and that the invention can be implemented in other specific forms without departing from its spirit or essential characteristics. Therefore, the embodiments should be considered in all respects as exemplary and non-limiting, and the scope of the invention is defined by the appended claims rather than the foregoing description. Thus, all variations falling within the meaning and scope of equivalents of the claims are intended to be included within the present invention. No reference numerals in the claims should be construed as limiting the scope of the claims.

[0044] Furthermore, it should be understood that although this specification describes embodiments, not every embodiment contains only one independent technical solution. This narrative style is merely for clarity. Those skilled in the art should consider the specification as a whole, and the technical solutions in each embodiment can also be appropriately combined to form other embodiments that can be understood by those skilled in the art.

Claims

1. A podophyllotoxin separation and purification device, characterized in that, include: A chopping centrifuge (100) is used to chop the rhizomes and flowers of Podophyllum plants; Juice pressing mechanism (200), the juice pressing mechanism (200) is used to press the juice from chopped roots, stems and leaves. The juice pressing mechanism (200) includes a fixed ring plate (201), the top of the fixed ring plate (201) is fixedly connected to a mounting bracket (202), the inner wall of the fixed ring plate (201) is provided with a reciprocating spiral groove (203), an embedded slider (208) is slidably embedded in the reciprocating spiral groove (203), and an L-shaped rod (209) is fixedly connected to the end of the embedded slider (208). The bottom end of the L-shaped rod (209) is fixedly connected to a juice-pressing ring plate (210). A limiting cavity (211) is opened inside the juice-pressing ring plate (210). A limiting ring is rotatably sleeved in the limiting cavity (211). A sliding rod (212) is fixedly connected to the inner wall of the limiting ring. A positioning ring (213) is fixedly connected to the end of the sliding rod (212). A pressing round plate (214) is rotatably sleeved in the positioning ring (213). Multiple arc-shaped cutters (215) are fixedly connected at equal intervals in a ring at the bottom of the pressing round plate (214). A powder drying mechanism (300) is used to crush plant roots and stems into powder and perform circulating drying of the powder; The chopping and centrifuging mechanism (100) includes a tank (101) fixedly connected to a mounting frame (202). A rotating tank (102) is rotatably sleeved at the center of the tank (101). A filter plate (104) is screwed onto the bottom of the rotating tank (102). A drain pipe communicating with the inside of the tank (101) is fixedly connected to the bottom of the tank (101). A support frame (103) is fixedly installed on the outside of the tank (101). A toothed ring (105) is fixedly sleeved on the outer wall of the rotating tank (102). A spur gear (106) is meshed on one side of the toothed ring (105). The output end of a drive motor (107) is fixedly connected at the center of the spur gear (106). The drive motor (107) is fixedly connected to the inner wall of the tank (101). The rotating tank (102) has multiple centrifugal shells (108) fixedly connected at equal intervals in an annular shape inside, and centrifugal filter plates (109) are fixedly connected in each of the multiple centrifugal shells (108); multiple leaf cutting blades (110) are fixedly connected at equal intervals on the inner walls of the multiple centrifugal shells (108); a fixed cylinder (111) is sleeved at the center of the rotating tank (102); the top of the fixed cylinder (111) is fixedly connected to the bottom of the mounting frame (202); multiple fixed cutting blades (112) are fixedly connected at equal intervals in an annular shape on the outer wall of the fixed cylinder (111); and multiple sweeping blades (113) are fixedly connected at equal intervals in an annular shape at the bottom of the fixed cylinder (111). A rotating shaft (205) is provided at the center of the fixed cylinder (111). Multiple root cutting blades (206) are fixedly connected in a ring at equal intervals on the outer wall of the rotating shaft (205). Multiple fixed cutting blades (114) are fixedly connected in a ring at equal intervals on the inner wall of the fixed cylinder (111). The output end of a servo motor (204) is fixedly connected to the top of the rotating shaft (205). A linkage shaft (207) is fixedly connected to the bottom of the rotating shaft (205). The root pressing circular plate (214) is slidably sleeved with the linkage shaft (207). Two limiting grooves (115) are symmetrically opened on the inner wall of the rotating tank (102), and the juice pressing ring plate (210) is slidably engaged with the limiting grooves (115); The bottom of the fixed cylinder (111) is fixedly connected to the flared cylinder (216) which communicates with its interior. The pressing circular plate (214) is slidably sleeved with the flared cylinder (216). A vertical groove (218) is opened on the flared cylinder (216). The sliding rod (212) is slidably connected with the vertical groove (218). Multiple filter holes (217) are circumferentially and evenly spaced on the outer wall of the flared cylinder (216).

2. The podophyllotoxin separation and purification apparatus according to claim 1, characterized in that, A truncated cone (219) is fixedly sleeved on the outer wall of the flared cylinder (216).

3. The podophyllotoxin separation and purification apparatus according to claim 2, characterized in that, The powder drying mechanism (300) includes a connecting cylinder (301) fixedly connected to the bottom end of the flared cylinder (216), a pulverizing cylinder (302) fixedly connected to the bottom end of the connecting cylinder (301), a servo motor (303) fixedly connected to the end of the pulverizing cylinder (302), a pulverizing blade shaft (304) fixedly connected to the output end of the servo motor (303), the output end of a hot air blower (305) fixedly connected to the side wall of the pulverizing cylinder (302), a circulation pipe (306) fixedly connected to the end of the pulverizing cylinder (302) and communicating with its interior, a powder outlet pipe (307) fixedly connected to the circulation pipe (306), a solenoid valve (308) fixedly installed in the powder outlet pipe (307), and a solenoid valve (309) fixedly installed in the circulation pipe (306).

4. The podophyllotoxin separation and purification apparatus according to claim 3, characterized in that, The top of the connecting cylinder (301) is provided with a sealing block (310), and the bottom of the sealing block (310) is symmetrically and fixedly connected with two compression springs (311) that are fixedly connected to the inner wall of the connecting cylinder (301).

Images