An apparatus and method for constructing an animal model of craniocerebral injury

Abstract

The present invention provides a device and a construction method for constructing an animal model of craniocerebral injury, belonging to the field of medical experiments. It includes a bottom plate, a platform is fixedly connected to the top end of the bottom plate, side plates are fixedly connected to both the left and right sides of the bottom plate, top plates are fixedly connected to the top ends of the two side plates, a hollow column is arranged on the top plate, and a first adjustment component for adjusting the hardness is arranged on the hollow column. An experimental animal is placed on the platform, and the hardness of the impact head is adjusted through the first adjustment component, facilitating the simulation of impact objects with different sharpness degrees. When adjusted to an appropriate degree, the angle of the impact head is adjusted and locked through a locking component. Subsequently, the second adjustment component is squeezed through a squeezing component, enabling the second adjustment component to adjust the center of gravity of the impact head. After the adjustment is completed, the falling component is moved to make the hollow column impact the head of the experimental animal, thereby improving the practicability of the device.

Description

Technical Field

[0001] The present invention relates to the field of medical experiments, and more specifically, to a device and method for constructing an animal model of craniocerebral injury. Background Art

[0002] The device for constructing an animal model of craniocerebral injury includes biomedical engineering, neuroscience, animal experiment techniques, etc. The device for constructing an animal model of craniocerebral injury usually simulates different types of craniocerebral injuries by precisely controlling impact parameters (such as impact speed, impact angle, impact force, etc.), providing an important experimental means for studying the pathological changes, nerve repair and drug intervention effects after craniocerebral injury;

[0003] In the process of using the existing device for constructing an animal model of craniocerebral injury, an impact head is usually set to impact the experimental animal. At present, the impact head is fixedly installed on the device. Therefore, the current device cannot study the situation of impacting the animal with impact heads of different sharpness degrees, and can only cooperate with different construction devices to achieve the purpose of impacting the animal with impact heads of different sharpness degrees. Such an operation method is rather cumbersome, the model construction efficiency is low, and the usability needs to be improved. Summary of the Invention

[0004] Aiming at the problem existing in the prior art that the current impact head is fixedly installed on the device, so the current device cannot study the situation of impacting the animal with impact heads of different sharpness degrees, resulting in limitations in the use of the impact block, the purpose of the present invention is to provide a device and method for constructing an animal model of craniocerebral injury.

[0005] To solve the above problems, the present invention adopts the following technical solutions:

[0006] A device and method for constructing an animal model of craniocerebral injury, including a bottom plate. The top end of the bottom plate is fixedly connected with a platform. Both the left and right sides of the bottom plate are fixedly connected with side plates. The top ends of the two side plates are fixedly connected with a top plate. A hollow column is arranged on the top plate. A first adjusting component for adjusting the hardness is arranged on the hollow column. A locking component for locking the first adjusting component is arranged on the hollow column. A second adjusting component for adjusting the center of gravity is arranged on the hollow column. An extrusion component is arranged on the hollow column. A retracting component and a falling component for retracting and falling the hollow column are arranged on the top plate.

[0007] Optionally, the first adjusting component includes an annular plate. A rotating groove is formed in the hollow column, and the annular plate is rotatably connected in the rotating groove. The outer surface of the annular plate is fixedly connected with a first impact block, a second impact block, a third impact block and a fourth impact block. The sharpness of the tips of the first impact block, the second impact block, the third impact block and the fourth impact block is different, and the first impact block is directly below the annular plate.

[0008] Optionally, the locking component includes a rectangular sleeve fixedly connected to the front end of the hollow column. A sliding block is slidably connected to the inner wall of the rectangular sleeve. A first spring is fixedly connected between the inner wall of the rectangular sleeve and the sliding block. One side of the sliding block is fixedly connected with a handle, and the handle slidably penetrates through one end of the rectangular sleeve. The top end of the sliding block is fixedly connected with a connecting plate, and the connecting plate slidably penetrates through the top end of the rectangular sleeve. The rear end of the connecting plate is fixedly connected with a bolt, and the bolt slidably penetrates through the front end of the hollow column. A plurality of slots matching with the bolt are formed in the annular plate, and the plurality of slots are arranged in a circumferential manner.

[0009] Optionally, the second adjusting component includes a solid column fixedly connected to the inner wall of the hollow column. An airbag is fixedly connected to the inner wall of the hollow column, and the airbag is located outside the solid column. Four partition plates are fixedly connected to the inner wall of the airbag. A first area, a second area, a third area and a fourth area are arranged in the airbag through the partition plates. The first area is directly below the solid column. Through holes are formed in all four partition plates, and the first area, the second area, the third area and the fourth area are communicated through the through holes.

[0010] Optionally, the pressing component includes a connecting shaft rotatably connected to the middle of the solid column. A top block is fixedly connected to the outer surface of the connecting shaft. A circular groove is formed in the middle of the solid column, and the top block is rotatably connected in the circular groove. Four push rods are slidably connected to the solid column. An arc-shaped plate is fixedly connected to one side of each of the four push rods away from the connecting shaft. A connecting rod is fixedly connected to the front end of the connecting shaft, and the connecting rod rotatably penetrates through the front end of the hollow column. A knob is fixedly connected to the front end of the connecting rod.

[0011] Optionally, a first gear is slidably connected to the outer surface of the connecting rod. A first magnet is fixedly connected to the rear end of the first gear. A circular block is fixedly connected to the front end of the hollow column. A tooth groove matching with the first gear is formed in the circular block, and a second magnet is fixedly connected to the circular block.

[0012] Optionally, the retracting assembly includes four sliding rods, the four sliding rods are fixedly connected to the outer surface of the hollow column, the tops of the four sliding rods are fixedly connected to the same rectangular plate, a rack plate is fixedly connected to the outer surface of one of the sliding rods, the rack plate and the four sliding rods slidably penetrate through the top plate, a moving plate is slidably connected to the top of the top plate, a fixing plate is fixedly connected to the top of the moving plate, a motor is fixedly connected to the front end of the fixing plate, an output end of the motor is fixedly connected to a second gear, and the second gear meshes with the rack plate.

[0013] Optionally, the falling assembly includes a positioning plate, the positioning plate is fixedly connected to the top of the top plate, two second springs are fixedly connected between the right side of the positioning plate and the moving plate, the second springs are in a stretched state, a T-shaped plate is slidably connected to the top of the top plate, and a limiting groove matching with the T-shaped plate is formed in the moving plate.

[0014] Optionally, two T-shaped sliders are fixedly connected to the inner wall of the circular ring plate, and a T-shaped sliding groove matching with the T-shaped sliders is formed in the hollow column.

[0015] A method for constructing an animal model of craniocerebral injury:

[0016] S1: Select a suitable experimental animal and place it on a platform for fixation;

[0017] S2: Select a suitable impact head according to the situation of the experimental animal through the first adjustment assembly, and adjust the center of gravity of the impact head through the second adjustment assembly;

[0018] S3: Release the impact head through the falling assembly so that the impact head impacts the animal's head at a set speed and force;

[0019] S4: Observe and record the animal's reaction, the injury condition of the craniocerebrum, and the behavioral changes;

[0020] S5: Statistically analyze the collected data to evaluate the influence of the sharpness of the impact object and different center of gravity positions of the impact head on craniocerebral injury.

[0021] The technical solution provided by the present invention has at least the following beneficial effects compared with the prior art:

[0022] In the above solution, when it is necessary to impact the head of an experimental animal, the experimental animal is placed on the platform. The hardness of the impact head is adjusted through the first adjustment component, facilitating the simulation of impact objects with different sharpness levels. When the hardness of the impact head is adjusted to an appropriate level, the first adjustment component is adjusted and locked in terms of angle through the locking component, facilitating the staff to adjust the impact angle of the impact head according to the experimental requirements. Subsequently, the second adjustment component is squeezed through the squeezing component, enabling the second adjustment component to adjust the center of gravity of the impact head. After the adjustment is completed, the falling component is moved to make the hollow column impact the head of the experimental animal, thereby improving the practicality of the device;

[0023] When it is necessary to impact the cranium of an experimental animal with different impact heads, the circular ring plate is rotated. The circular ring plate drives the first impact block, the second impact block, the third impact block, and the fourth impact block to rotate simultaneously. By means of the different sharpness levels at the tips of the first impact block, the second impact block, the third impact block, and the fourth impact block, impact objects with different sharpness levels can be simulated. One of the impact heads of the first impact block, the second impact block, the third impact block, and the fourth impact block is aligned with the head of the experimental animal, ensuring that the contact area and impact force distribution between the first impact block, the second impact block, the third impact block, and the fourth impact block and the animal's head during impact are uniform, avoiding errors caused by different shapes, and ensuring that the impact forces generated by the first impact block, the second impact block, the third impact block, and the fourth impact block with different sharpness levels are consistent under the same conditions, achieving the control of different impact effects produced by impacting the head of the experimental animal with impact heads of different sharpness;

[0024] When it is necessary to lock the circular ring plate, the handle is pulled. The handle drives the sliding block to slide, and the first spring is compressed. The sliding block drives the connecting plate and the plug, causing the plug to leave the slot. Subsequently, the circular ring plate is rotated. The circular ring plate drives the first impact block, the second impact block, the third impact block, and the fourth impact block to rotate. When the angle of one of the impact heads is rotated to a position suitable for impacting the head of the experimental animal, the handle is released. The first spring rebounds, and the sliding block drives the connecting plate and the plug, causing the plug to insert into the corresponding slot, restricting the circular ring plate and the first impact block, the second impact block, the third impact block, and the fourth impact block. The staff can adjust the impact angles of the first impact block, the second impact block, the third impact block, and the fourth impact block according to the experimental requirements to test the injury degrees of different experimental animals, ensuring that there are no errors caused by angle changes during the impact process;

[0025] When it is necessary to adjust the center of gravity of the hollow column, one of the four regions in the airbag is squeezed through the squeezing component. The liquid in the squeezed region enters the other three regions through the through holes. The region directly opposite the squeezed region receives the most liquid flowing in, causing the center of gravity of the hollow column to shift to the region with the most liquid, facilitating the testing of different injury effects on the cranium by adjusting the shift of the center of gravity of the impact head. Brief Description of the Drawings

[0026] The drawings incorporated herein and constituting a part of the specification illustrate embodiments of the present invention and, together with the specification, are further used to explain the principles of the present invention and enable those skilled in the relevant art to implement and use the present invention.

[0027] Figure 1 Schematic three-dimensional structure diagram of the present invention;

[0028] Figure 2 of the present invention Figure 1 Schematic enlarged structure diagram at A;

[0029] Figure 3 Schematic structure diagram of the rotating groove and T-shaped sliding groove of the present invention;

[0030] Figure 4 Schematic structure diagram of the first adjustment component of the present invention;

[0031] Figure 5 Schematic structure diagram of the first impact block, second impact block, third impact block and fourth impact block of the present invention;

[0032] Figure 6 Schematic structure diagram of the locking component of the present invention;

[0033] Figure 7 Schematic right view sectional structure diagram of the hollow column of the present invention;

[0034] Figure 8 Schematic structure diagram of the second adjustment component of the present invention;

[0035] Figure 9 Schematic structure diagram of the extrusion component of the present invention;

[0036] Figure 10 Schematic structure diagram of the first gear and tooth groove of the present invention;

[0037] Figure 11 Schematic structure diagram of the retracting component and the falling component of the present invention.

[0038] [Reference Signs]

[0039] 101. Bottom plate; 102. Platform; 103. Side plate; 104. Top plate; 105. Hollow column; 201. Ring plate; 202. Rotating groove; 203. First impact block; 204. Second impact block; 205. Third impact block; 206. Fourth impact block; 207. Rectangular sleeve; 208. Sliding block; 209. First spring; 210. Handle; 211. Connecting plate; 212. Bolt; 213. Slot; 214. Solid column; 215. Airbag; 216. Partition; 217. First region; 218. Second region; 219. Third region; 220. Fourth region; 221. Through hole; 222. Connecting shaft; 223. Top block; 224. Circular groove; 225. Push rod; 226. Arc plate; 227. Connecting rod; 228. Knob; 229. First gear; 230. First magnet; 231. Round block; 232. Tooth groove; 233. Second magnet; 234. Slide bar; 235. Rectangular plate; 236. Rack plate; 237. Moving plate; 238. Fixed plate; 239. Motor; 240. Second gear; 241. Positioning plate; 242. Second spring; 243. T-shaped plate; 244. Limiting groove; 245. T-shaped slider; 246. T-shaped sliding groove.

[0040] As shown in the figure, in order to clearly show the structure of the embodiments of the present invention, specific structures and devices are marked in the figure. However, this is only for illustrative purposes and is not intended to limit the present invention to the specific structures, devices and environments. According to specific needs, those of ordinary skill in the art can adjust or modify these devices and environments. Detailed implementation manners

[0041] The following describes in detail a device and method for constructing a craniocerebral injury animal model provided by the present invention in conjunction with the accompanying drawings and specific embodiments. At the same time, it should be noted here that in order to make the embodiments more detailed, the following embodiments are the best and preferred embodiments. For some well-known technologies, those skilled in the art can also adopt other alternative methods for implementation; moreover, the accompanying drawings are only for more specific description of the embodiments and are not intended to specifically limit the present invention.

[0042] It should be noted that in the specification, references to "an embodiment", "embodiments", "exemplary embodiments", "some embodiments", etc. indicate that the described embodiments may include specific features, structures or characteristics, but not necessarily every embodiment includes the specific feature, structure or characteristic. Additionally, when combining embodiments to describe a specific feature, structure or characteristic, implementing such feature, structure or characteristic in combination with other embodiments (whether explicitly described or not) should be within the knowledge of those skilled in the relevant art.

[0043] Generally, terms can be understood, at least in part, from their use in context. For example, depending at least in part on the context, the term "one or more" as used herein can be used to describe any feature, structure, or characteristic in a singular sense, or can be used to describe a combination of features, structures, or characteristics in a plural sense. Additionally, the term "based on" can be understood as not necessarily intended to convey a set of exclusive factors, but rather can alternatively, at least in part depending on the context, allow for the existence of other factors that are not necessarily explicitly described.

[0044] It can be understood that the meanings of "on", "above", and "over" in the present invention should be construed in the broadest manner such that "on" not only means "directly on" something, but also includes the meaning of being "on" something with intervening features or layers therebetween, and "above" or "over" not only means "above" or "over" something, but can also include the meaning of being "above" or "over" something with no intervening features or layers therebetween.

[0045] Furthermore, spatial relative terms such as "under", "below", "lower", "above", "upper", etc. may be used herein for convenience of description to describe the relationship of one element or feature to another or other elements or features, as shown in the drawings. The spatial relative terms are intended to cover different orientations in the use or operation of the device in addition to the orientation depicted in the drawings. The device may be oriented in other ways, and the spatial relative descriptors used herein may be interpreted accordingly.

[0046] As Figures 1 to 11 shown, an embodiment of the present invention provides a device for constructing an animal model of traumatic brain injury, including a bottom plate 101, a platform 102 is fixedly connected to the top end of the bottom plate 101, side plates 103 are fixedly connected to both the left and right sides of the bottom plate 101, top plates 104 are fixedly connected to the top ends of the two side plates 103, a hollow column 105 is provided on the top plate 104, a first adjustment assembly for adjusting the hardness is provided on the hollow column 105, a locking assembly for locking the first adjustment assembly is provided on the hollow column 105, a second adjustment assembly for adjusting the center of gravity is provided on the hollow column 105, a pressing assembly is provided on the hollow column 105, and a retracting assembly and a dropping assembly for retracting and dropping the hollow column 105 are provided on the top plate 104.

[0047] When it is necessary to impact the head of an experimental animal, place the experimental animal on the platform 102, adjust the hardness of the impact head through the first adjustment component, so as to simulate impact objects with different sharpness levels. When the hardness of the impact head is adjusted to an appropriate level, adjust and lock the angle of the first adjustment component through the locking component, which is convenient for the staff to adjust the impact angle of the impact head according to the experimental requirements. Subsequently, squeeze the second adjustment component through the squeezing component, so that the second adjustment component adjusts the center of gravity of the impact head. After the adjustment is completed, move the falling component so that the hollow column 105 impacts the head of the experimental animal, thereby improving the practicability of the device.

[0048] As Figures 3 to 5 shown, the first adjustment component includes a circular ring plate 201. A rotation groove 202 is formed on the hollow column 105. The circular ring plate 201 is rotatably connected in the rotation groove 202. The outer surface of the circular ring plate 201 is fixedly connected with a first impact block 203, a second impact block 204, a third impact block 205 and a fourth impact block 206. The sharpness levels of the tips of the first impact block 203, the second impact block 204, the third impact block 205 and the fourth impact block 206 are different. The first impact block 203 is directly below the circular ring plate 201.

[0049] When it is necessary to impact the skull of an experimental animal with different impact heads, rotate the circular ring plate 201. The circular ring plate 201 drives the first impact block 203, the second impact block 204, the third impact block 205 and the fourth impact block 206 to rotate simultaneously. Through the different sharpness levels of the tips of the first impact block 203, the second impact block 204, the third impact block 205 and the fourth impact block 206, impact objects with different sharpness levels can be simulated, so that one of the first impact block 203, the second impact block 204, the third impact block 205 and the fourth impact block 206 is directly opposite to the head of the experimental animal, ensuring that the contact area and impact force distribution between the first impact block 203, the second impact block 204, the third impact block 205 and the fourth impact block 206 and the animal's head during impact are uniform, avoiding errors caused by different shapes, and ensuring that the impact forces generated by the first impact block 203, the second impact block 204, the third impact block 205 and the fourth impact block 206 with different sharpness levels are consistent under the same conditions, so as to achieve the control of different impact effects when different sharp impact heads impact the head of the experimental animal.

[0050] As Figure 6As shown, the locking component includes a rectangular sleeve 207, the rectangular sleeve 207 is fixedly connected to the front end of the hollow column 105, a sliding block 208 is slidably connected to the inner wall of the rectangular sleeve 207, a first spring 209 is fixedly connected between the inner wall of the rectangular sleeve 207 and the sliding block 208, a handle 210 is fixedly connected to one side of the sliding block 208, the handle 210 slidably penetrates through one end of the rectangular sleeve 207, a connecting plate 211 is fixedly connected to the top end of the sliding block 208, the connecting plate 211 slidably penetrates through the top end of the rectangular sleeve 207, a latch 212 is fixedly connected to the rear end of the connecting plate 211, the latch 212 slidably penetrates through the front end of the hollow column 105, and a plurality of slots 213 which cooperate with the latch 212 are formed in the circular ring plate 201, and the plurality of slots 213 are arranged in a circumferential manner.

[0051] When it is necessary to lock the circular ring plate 201, pull the handle 210, the handle 210 drives the sliding block 208 to slide, the first spring 209 is compressed, the sliding block 208 drives the connecting plate 211 and the latch 212, so that the latch 212 leaves the slot 213. Subsequently, rotate the circular ring plate 201, the circular ring plate 201 drives the first impact block 203, the second impact block 204, the third impact block 205 and the fourth impact block 206 to rotate. When the angle of one of the impact heads is rotated to a position suitable for impacting the head of the experimental animal, release the handle 210, the first spring 209 rebounds, the sliding block 208 drives the connecting plate 211 and the latch 212, so that the latch 212 is inserted into the corresponding slot 213 to limit the circular ring plate 201 and the first impact block 203, the second impact block 204, the third impact block 205 and the fourth impact block 206. The staff can adjust the impact angles of the first impact block 203, the second impact block 204, the third impact block 205 and the fourth impact block 206 according to the experimental requirements to test the injury degrees of different experimental animals and ensure that there will be no errors caused by angle changes during the impact process.

[0052] As Figure 7 and Figure 8 As shown, the second adjustment component includes a solid column 214, the solid column 214 is fixedly connected to the inner wall of the hollow column 105, an airbag 215 is fixedly connected to the inner wall of the hollow column 105, the airbag 215 is located outside the solid column 214, four partition plates 216 are fixedly connected to the inner wall of the airbag 215, a first area 217, a second area 218, a third area 219 and a fourth area 220 are arranged in the airbag 215 through the partition plates 216, the first area 217 is located directly below the solid column 214, through holes 221 are formed in all four partition plates 216, and the first area 217, the second area 218, the third area 219 and the fourth area 220 are communicated through the through holes 221.

[0053] When it is necessary to adjust the center of gravity of the hollow column 105, one of the four regions in the airbag 215 is squeezed by the squeezing assembly, and the liquid in the squeezed region enters the other three regions through the through holes 221. The region directly opposite the squeezed region receives the most liquid, causing the center of gravity of the hollow column 105 to shift to the region with the most liquid, facilitating the testing of different damage effects on the brain by adjusting the shift of the center of gravity of the impact head.

[0054] As Figure 9 shown, the squeezing assembly includes a connecting shaft 222 which is rotatably connected to the middle of the solid column 214. The outer surface of the connecting shaft 222 is fixedly connected with a top block 223. A circular groove 224 is opened in the middle of the solid column 214. The top block 223 is rotatably connected in the circular groove 224. Four push rods 225 are slidably connected to the solid column 214. One side of each of the four push rods 225 away from the connecting shaft 222 is fixedly connected with an arc-shaped plate 226. The front end of the connecting shaft 222 is fixedly connected with a connecting rod 227. The connecting rod 227 rotatably penetrates through the front end of the hollow column 105. The front end of the connecting rod 227 is fixedly connected with a knob 228.

[0055] When it is necessary to squeeze the airbag 215, turn the knob 228. The knob 228 drives the connecting rod 227 and the connecting shaft 222 to rotate. The connecting shaft 222 drives the top block 223 to rotate. When the top block 223 rotates to contact one of the push rods 225, the top block 223 can push the push rod 225 to move outwards. The push rod 225 drives the arc-shaped plate 226 to squeeze one of the first region 217, the second region 218, the third region 219 and the fourth region 220. The liquid in the squeezed region enters the other three regions through the through holes 221. The region directly opposite the squeezed region receives the most liquid, causing the center of gravity of the hollow column 105 to shift to the region with the most liquid, facilitating the testing of different damage effects on the brain by adjusting the shift of the center of gravity of the impact head.

[0056] As Figure 10 shown, a first gear 229 is slidably connected to the outer surface of the connecting rod 227. The rear end of the first gear 229 is fixedly connected with a first magnet 230. A circular block 231 is fixedly connected to the front end of the hollow column 105. A tooth groove 232 that cooperates with the first gear 229 is opened in the circular block 231. A second magnet 233 is fixedly connected to the circular block 231.

[0057] When it is necessary to lock the top block 223, turn the knob 228. The knob 228 drives the connecting rod 227 and the connecting shaft 222 to rotate. The connecting shaft 222 drives the top block 223 to rotate to adjust the center of gravity of the hollow column 105. After the adjustment is completed, slide the first gear 229. The first gear 229 drives the first magnet 230 to slide. Slide the first gear 229 into the tooth groove 232, and attract the first magnet 230 through the second magnet 233 to restrict the first gear 229 and prevent the connecting rod 227 and the connecting shaft 222 from rotating randomly.

[0058] As Figure 1 and Figure 11 shown, the retracting assembly includes four slide rods 234. The four slide rods 234 are fixedly connected to the outer surface of the hollow column 105. The tops of the four slide rods 234 are fixedly connected to the same rectangular plate 235. A rack plate 236 is fixedly connected to the outer surface of one of the slide rods 234. The rack plate 236 and the four slide rods 234 slide through the top plate 104. A moving plate 237 is slidably connected to the top of the top plate 104. A fixing plate 238 is fixedly connected to the top of the moving plate 237. A motor 239 is fixedly connected to the front end of the fixing plate 238. The output end of the motor 239 is fixedly connected to a second gear 240. The second gear 240 meshes with the rack plate 236.

[0059] When the device is used up and the hollow column 105 needs to be retracted, the second gear 240 is engaged with the rack plate 236 through the falling assembly. Subsequently, start the motor 239. The output end of the motor 239 drives the second gear 240 to rotate. The second gear 240 drives the rack plate 236 to move upward. The rack plate 236 drives one of the rack plates 236 and the rectangular plate 235 to move. The rectangular plate 235 drives the other three slide rods 234 to move. The four slide rods 234 simultaneously drive the hollow column 105 to move upward to retract the hollow column 105, facilitating the next use of the hollow column 105.

[0060] As Figure 11 shown, the falling assembly includes a positioning plate 241. The positioning plate 241 is fixedly connected to the top of the top plate 104. Two second springs 242 are fixedly connected between the right side of the positioning plate 241 and the moving plate 237. The second springs 242 are in a stretched state. A T-shaped plate 243 is slidably connected to the top of the top plate 104. A limiting groove 244 that cooperates with the T-shaped plate 243 is formed in the moving plate 237.

[0061] When the hollow column 105 needs to fall, pull the T-shaped plate 243, pull the T-shaped plate 243 out of the limit groove 244, the second spring 242 rebounds, drives the moving plate 237 to move towards the positioning plate 241, the moving plate 237 drives the motor 239 and the second gear 240 to move, so that the second gear 240 is not in contact with the rack plate 236. When the second gear 240 is not meshed with the rack plate 236, under the action of gravity, the hollow column 105 moves downward rapidly to impact the head of the experimental animal, which is convenient for simulating brain injuries caused by external forces such as falling and impact in reality.

[0062] As Figure 3 and Figure 4 shown, two T-shaped sliders 245 are fixedly connected to the inner wall of the ring plate 201, and T-shaped sliding grooves 246 cooperating with the T-shaped sliders 245 are formed on the hollow column 105.

[0063] By providing the T-shaped sliders 245 and the T-shaped sliding grooves 246, when the ring plate 201 rotates, the ring plate 201 will drive the T-shaped sliders 245 to slide in the T-shaped sliding grooves 246. The T-shaped sliding grooves 246 can play a role in limiting and guiding the T-shaped sliders 245 and the ring plate 201, thereby improving the stability of the ring plate 201 during rotation.

[0064] The working process of the technical solution of the present invention is as follows:

[0065] During use, place the experimental animal on the platform 102, pull the handle 210, the handle 210 drives the sliding block 208 to slide, the first spring 209 is compressed, the sliding block 208 drives the connecting plate 211 and the plug 212, so that the plug 212 leaves the slot 213, rotate the ring plate 201, the ring plate 201 drives the first impact block 203, the second impact block 204, the third impact block 205 and the fourth impact block 206 to rotate simultaneously, so that one of the impact heads is facing the head of the experimental animal, release the handle 210, the first spring 209 rebounds, the sliding block 208 drives the connecting plate 211 and the plug 212, so that the plug 212 is inserted into the slot 213 to limit the ring plate 201 and the impact head. Turn the knob 228, the knob 228 drives the connecting rod 227 and the connecting shaft 222 to rotate, the connecting shaft 222 drives the top block 223 to rotate. When the top block 223 rotates to contact one of the push rods 225, the top block 223 can push the push rod 225 to move outward, the push rod 225 drives the arc plate 226 to squeeze one of the first area 217, the second area 218, the third area 219 and the fourth area 220. The liquid in the squeezed area enters the other three areas through the through hole 221. The area facing the squeezed area receives the most liquid flowing in, so that the center of gravity of the hollow column 105 shifts to the area with the most liquid, which is convenient for testing different injury effects on the brain by adjusting the center of gravity shift of the impact head.

[0066] After that, slide the first gear 229. The first gear 229 drives the first magnet 230 to slide. Slide the first gear 229 into the tooth groove 232, and attract the first magnet 230 through the second magnet 233 to restrict the first gear 229, preventing the connecting rod 227 and the connecting shaft 222 from rotating randomly. Pull the T-shaped plate 243 and pull the T-shaped plate 243 out of the limit groove 244. The second spring 242 rebounds, driving the moving plate 237 to move towards the positioning plate 241. The moving plate 237 drives the motor 239 and the second gear 240 to move, so that the second gear 240 is not in contact with the rack plate 236. When the second gear 240 is not meshed with the rack plate 236, under the action of gravity, the hollow column 105 drives the impact head to move downward rapidly to impact the head of the experimental animal. After the impact is completed, move the falling component to make the second gear 240 mesh with the rack plate 236. Subsequently, start the motor 239. The output end of the motor 239 drives the second gear 240 to rotate. The second gear 240 drives the rack plate 236 to move upward. The rack plate 236 drives one of the rack plates 236 and the rectangular plate 235 to move. The rectangular plate 235 drives the other three sliding rods 234 to move. The four sliding rods 234 simultaneously drive the hollow column 105 to move upward to retract the hollow column 105, facilitating the next impact of the impact head.

[0067] The present invention covers any alternatives, modifications, equivalent methods, and solutions made within the spirit and scope of the present invention. To enable the public to have a thorough understanding of the present invention, specific details are described in detail in the following preferred embodiments of the present invention. However, those skilled in the art can fully understand the present invention without the description of these details. Additionally, well-known methods, processes, procedures, components, and circuits are not described in detail to avoid unnecessary confusion to the essence of the present invention.

[0068] The above are only the preferred embodiments of the present invention. It should be noted that for those of ordinary skill in the art, without departing from the principle of the present invention, several improvements and refinements can be made, and these improvements and refinements should also be regarded as the protection scope of the present invention.

Claims

1. An apparatus for constructing an animal model of craniocerebral injury, comprising a bottom plate, characterized in that, A platform is fixedly connected to the top end of the bottom plate. Side plates are fixedly connected to both the left and right sides of the bottom plate. Top plates are fixedly connected to the top ends of the two side plates. A hollow column is provided on the top plate. A first adjustment component for adjusting the hardness is provided on the hollow column. A locking component for locking the first adjustment component is provided on the hollow column. A second adjustment component for adjusting the center of gravity is provided on the hollow column. An extrusion component is provided on the hollow column. A retraction component and a dropping component for retracting and dropping the hollow column are provided on the top plate. The second adjustment component includes a solid column fixedly connected to the inner wall of the hollow column. An airbag is fixedly connected to the inner wall of the hollow column, and the airbag is located outside the solid column. Four partition plates are fixedly connected to the inner wall of the airbag. The airbag is provided with a first area, a second area, a third area, and a fourth area through the partition plates. The first area is directly below the solid column. Through holes are provided on all four partition plates, and the first area, the second area, the third area, and the fourth area are connected through the through holes. The extrusion component includes a connecting shaft rotatably connected to the middle of the solid column. A top block is fixedly connected to the outer surface of the connecting shaft. A circular groove is provided in the middle of the solid column, and the top block is rotatably connected in the circular groove. Four push rods are slidably connected to the solid column. Arc-shaped plates are fixedly connected to one side of the four push rods away from the connecting shaft. A connecting rod is fixedly connected to the front end of the connecting shaft, and the connecting rod rotatably penetrates through the front end of the hollow column. A knob is fixedly connected to the front end of the connecting rod.

2. The device for constructing a craniocerebral injury animal model according to claim 1, characterized in that, The first adjustment component includes an annular plate. A rotation groove is provided on the hollow column, and the annular plate is rotatably connected in the rotation groove. First impact blocks, second impact blocks, third impact blocks, and fourth impact blocks are fixedly connected to the outer surface of the annular plate. The sharpness of the tips of the first impact block, the second impact block, the third impact block, and the fourth impact block is different, and the first impact block is directly below the annular plate.

3. The device for constructing a craniocerebral injury animal model according to claim 2, wherein, The locking component includes a rectangular sleeve fixedly connected to the front end of the hollow column. A sliding block is slidably connected to the inner wall of the rectangular sleeve. A first spring is fixedly connected between the inner wall of the rectangular sleeve and the sliding block. A handle is fixedly connected to one side of the sliding block, and the handle slidably penetrates through one end of the rectangular sleeve. A connecting plate is fixedly connected to the top end of the sliding block, and the connecting plate slidably penetrates through the top end of the rectangular sleeve. A bolt is fixedly connected to the rear end of the connecting plate, and the bolt slidably penetrates through the front end of the hollow column. A plurality of slots that cooperate with the bolt are provided on the annular plate, and the plurality of slots are arranged in a circle.

4. The device for constructing a craniocerebral injury animal model according to claim 1, characterized in that A first gear is slidably connected to the outer surface of the connecting rod. A first magnet is fixedly connected to the rear end of the first gear. A circular block is fixedly connected to the front end of the hollow column. A tooth groove that cooperates with the first gear is provided on the circular block. A second magnet is fixedly connected to the circular block.

5. The device for constructing a craniocerebral injury animal model according to claim 4, characterized in that, The retracting assembly includes four sliding rods, the four sliding rods are fixedly connected to the outer surface of the hollow column, the tops of the four sliding rods are fixedly connected to the same rectangular plate, a rack plate is fixedly connected to the outer surface of one of the sliding rods, the rack plate and the four sliding rods slidably penetrate through the top plate, a moving plate is slidably connected to the top of the top plate, a fixing plate is fixedly connected to the top of the moving plate, a motor is fixedly connected to the front end of the fixing plate, an output end of the motor is fixedly connected to a second gear, and the second gear meshes with the rack plate.

6. The device for constructing an animal model of craniocerebral injury according to claim 5, wherein The falling assembly includes a positioning plate, the positioning plate is fixedly connected to the top of the top plate, two second springs are fixedly connected between the right side of the positioning plate and the moving plate, the second springs are in a stretched state, a T-shaped plate is slidably connected to the top of the top plate, and a limiting groove matching with the T-shaped plate is formed in the moving plate.

7. The device for constructing an animal model of craniocerebral injury according to claim 2, characterized in that, Two T-shaped sliders are fixedly connected to the inner wall of the circular ring plate, and a T-shaped sliding groove matching with the T-shaped sliders is formed in the hollow column.

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