Pachyrhizua angulatus formula granules and preparation method thereof
The concentrate of powdered pueraria medicinal tablets was dried by spray drying, and mixed with modified maltodextrin and auxiliary materials to make granulation, which solved the problem of inconsistent product quality and unstable efficacy of the existing powdered pueraria formula granules, and achieved the uniformity of the active ingredients and the stability of the efficacy of the product.
Patent Information
- Application Number
- CN202411549945.9
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-11-01
- Publication Date
- 2025-03-07
AI Technical Summary
The product quality of existing powdered gland formula granules is inconsistent, the efficacy varies, and the distribution of active ingredients during the granulation process leads to unstable efficacy.
Spray drying technology is used to dry the concentrate of the powdered puerar medicinal tablets, and the resulting dry paste powder is mixed with modified maltodextrin and auxiliary materials to form powdered puerar formula granules.
The drying efficiency is improved through spray drying technology, the loss of active ingredients is reduced, and the obtained powder is more uniform and delicate, ensuring the uniformity of the active ingredients of the product, facilitating the control of product quality, and improving the stability of the efficacy.
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Abstract
Description
Technical Field
[0001] The invention relates to the technical field of traditional Chinese medicine preparation, and in particular to kudzu root formula granules and a preparation method thereof. Background Art
[0002] Chinese medicine formula granules are granules made from Chinese medicine pieces through various processes under the guidance of traditional Chinese medicine theory, and are used in clinical Chinese medicine prescriptions. Compared with traditional Chinese medicine decoctions, they are easy to take, small in dosage, controllable in quality, easy to store and carry. Chinese medicine formula granules are currently in the pilot production stage in China, and the product process and quality standards are not unified. Pueraria formula granules are a type of commonly used Chinese medicine formula granules. Due to different production equipment and production processes, different production units have different product quality and different efficacy. Summary of the invention
[0003] In view of the defects of the prior art, the purpose of the present invention is to provide a kudzu vine formula granule and a preparation method thereof to solve the problems raised in the above background technology.
[0004] The present invention solves the technical problem by adopting the following technical solution: The present invention provides a method for preparing kudzu vine formula granules, comprising the following steps: Step 1, extracting and concentrating the Pueraria lobata medicinal material slices to obtain a concentrated solution; Step 2: adding modified maltodextrin to the concentrated solution obtained in step 1 and spray drying the solution to obtain a dry paste powder, wherein the modified maltodextrin is maltodextrin modified by a bioenzymatic method; Step three, mixing the dry paste powder with auxiliary materials and granulating them to obtain kudzu vine formula granules.
[0005] In the prior art, freeze drying and spray drying are commonly used technical methods by those skilled in the art. Freeze drying has little effect on the active ingredients in the drying process and can significantly reduce the loss of active ingredients in the drying process. However, the freeze-dried product needs to be further ground and refined into powder before it can be used for granulation, and the powder obtained by grinding has poor dispersion, which will lead to uneven distribution of active ingredients in the granulated product and unstable efficacy of the product. Therefore, in the technical scheme of the present application, the spray drying method is used to dry and spray the concentrated solution, which has high drying efficiency, less damage to the active ingredients and the obtained powder is more uniform and fine, which can ensure that the active ingredients of the subsequent production products are uniform and facilitate the control of product quality.
[0006] Preferably, the extraction and concentration in step 1 comprises the following steps: a1, soaking the Pueraria lobata medicinal material slices in water, heating for the first extraction, and then filtering to obtain filtrate I and filter residue; a2, adding water to the residue in a1, heating it for a second extraction, and filtering it to obtain filtrate II; a3. Combine the filtrate I and the filtrate II, and concentrate under reduced pressure and low temperature to obtain a concentrate.
[0007] In the above preferred embodiment, in order to make the effective ingredients in the Pueraria lobata medicinal material slices extracted more fully, the Pueraria lobata medicinal material slices were extracted twice to fully dissolve the effective ingredients in the Pueraria lobata medicinal material slices, and finally the filtrate I and filtrate II of the two extractions were combined. Since the volume of filtrate I and filtrate II is large, it is not convenient to dry them directly, so they need to be further concentrated before drying.
[0008] Preferably, the mass ratio of the Pueraria lobata medicinal material slices to water in a1 is 1:5-9, the mass ratio of the filter residue to water in a2 is 1:3-7, and the soaking time in a1 is 15-60 min.
[0009] Preferably, the heating temperature in a1 and a2 is 80-100° C., and the two extraction times are 0.5-1.5 h.
[0010] Preferably, the filtration mesh numbers in a1 and a2 are both 200 meshes.
[0011] Preferably, the reduced pressure concentration process is as follows: the concentration temperature is less than 65°C, the vacuum degree is ≥-0.08 MPa, and the concentration is performed to a relative density of 1.08-1.13 (60°C).
[0012] Preferably, the air supply temperature for spray drying in step 2 is 180-185°C.
[0013] Preferably, the amount of auxiliary materials used in step three is such that the dry paste powder is added with auxiliary materials so as to prepare 3.2 grams of medicinal pieces per gram of granules.
[0014] Preferably, the auxiliary material is any one of corn starch, dextrin and maltodextrin.
[0015] In the above preferred embodiment, generally speaking, the inlet air temperature of the spray drying is the most important factor affecting the physical and chemical properties of the spray-dried powder; a higher inlet air temperature provides more heat to the drying chamber, which increases the drying rate and reduces the moisture content of the spray-dried product. However, too high an inlet air temperature will cause the moisture to evaporate faster, so that the microspheres are formed faster and do not have enough time to shrink, resulting in a larger particle size of the obtained powder and easy to break, resulting in poor dispersion, and too high a temperature will also cause the occurrence of wall sticking. Therefore, taking comprehensive considerations, the inlet air temperature of the spray drying is controlled between 160-180°C.
[0016] The auxiliary materials are added to the dry paste powder of step 2, and 5-10% of the total amount of the dry paste powder of step 2 is added to the chitosan modified montmorillonite agent; The preparation method of chitosan modified montmorillonite agent is as follows: S01: adding a 10% sodium alginate aqueous solution to 5-10 times the mass fraction of a 2% hydrochloric acid solution and stirring evenly, then adding 1-5% of the total amount of montmorillonite glycolic acid and 2-5% of a 5% chitosan aqueous solution by mass fraction and stirring evenly to obtain a modifier; S02: The modifier of S01 and montmorillonite are mixed in a weight ratio of 1:10, and subjected to ball milling modification treatment. The ball milling speed is 1000-1500r / min, and the ball milling time is 20-30min. After the ball milling is completed, the mixture is washed with water and dried; S03: The ball-milled montmorillonite is heat-treated at 120-130°C for 5-10 minutes, then cooled to 40-45°C at a rate of 1-3°C / min, and then added to the modifier of S01 and stirred for modification. The stirring speed is 500-600r / min and the stirring time is 1-2h. After stirring, wash with water and dry to obtain the chitosan-modified montmorillonite agent.
[0017] The montmorillonite is firstly modified by ball milling with a modifier prepared by sodium alginate aqueous solution, hydrochloric acid solution, glycolic acid and chitosan aqueous solution. The montmorillonite is fully purified during the ball milling to improve the activity of the montmorillonite. The montmorillonite is modified while being ball milled. After the ball milling is completed, the montmorillonite is further modified by stirring with a modifier. After stirring, the montmorillonite is further dispersed and modified, so that the optimized montmorillonite can improve the dispersion of the product and optimize the performance effect of the product.
[0018] The present application also provides a kudzu vine root formula granule, which is prepared by the preparation method described in any of the above technical solutions.
[0019] Compared with the prior art, the present invention has the following beneficial effects: The technical solution of the present application also optimizes the extraction process of the effective ingredients in the Pueraria lobata medicinal material slices, so that the main active ingredients (such as Pueraria lobata extract) can be fully extracted, and inactive ingredients such as plant fiber can be effectively removed. The Pueraria lobata formula granules have good particle forming and uniform particle size, which further improves its utilization rate. The preparation method provided by the present application has good stability, simple steps, easy storage, low cost, and is suitable for industrial production. DETAILED DESCRIPTION
[0020] The following is a clear and complete description of the technical solutions in the embodiments of the present invention in conjunction with specific embodiments. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.
[0021] The present invention provides a kudzu vine root formula granule and a preparation method thereof, comprising the following steps: Step 1, extracting and concentrating the Pueraria lobata medicinal material slices to obtain a concentrated solution; Step 2, spray-drying the concentrated solution obtained in step 1 into a dry paste powder; Step 3: Add the auxiliary materials to the dry paste powder in step 2, mix evenly, and dry granulate to obtain the kudzu vine formula granules.
[0022] The auxiliary materials are added to the dry paste powder of step 2, and 5-10% of the total amount of the dry paste powder of step 2 is added to the chitosan modified montmorillonite agent; The preparation method of chitosan modified montmorillonite agent is as follows: S01: adding a 10% sodium alginate aqueous solution to 5-10 times the mass fraction of a 2% hydrochloric acid solution and stirring evenly, then adding 1-5% of the total amount of montmorillonite glycolic acid and 2-5% of a 5% chitosan aqueous solution by mass fraction and stirring evenly to obtain a modifier; S02: The modifier of S01 and montmorillonite are mixed in a weight ratio of 1:10, and subjected to ball milling modification treatment. The ball milling speed is 1000-1500r / min, and the ball milling time is 20-30min. After the ball milling is completed, the mixture is washed with water and dried; S03: The ball-milled montmorillonite is heat-treated at 120-130°C for 5-10 minutes, then cooled to 40-45°C at a rate of 1-3°C / min, and then added to the modifier of S01 and stirred for modification. The stirring speed is 500-600r / min and the stirring time is 1-2h. After stirring, wash with water and dry to obtain the chitosan-modified montmorillonite agent.
[0023] The extraction and concentration in step 1 of this embodiment includes the following steps: a1, soaking the Pueraria lobata medicinal material slices in water, heating for the first extraction, and then filtering to obtain filtrate I and filter residue; a2, adding water to the residue in a1, heating it for a second extraction, and filtering it to obtain filtrate II; a3. Combine the filtrate I and the filtrate II, and concentrate under reduced pressure and low temperature to obtain a concentrate.
[0024] In a1 of this embodiment, the mass ratio of the Pueraria lobata medicinal material slices to water is 1:5-9, the mass ratio of the filter residue to water in a2 is 1:3-7, and the soaking time in a1 is 15-60 min.
[0025] In a1 and a2 of this embodiment, the heating temperature is 80-100° C., and the extraction time for both times is 0.5-1.5 h.
[0026] The filtration mesh numbers in a1 and a2 of this embodiment are both 200 meshes.
[0027] The reduced pressure concentration process of this embodiment is as follows: the concentration temperature is less than 65°C, the vacuum degree is ≥-0.08mpa, and the concentration is performed to a relative density of 1.08-1.13 (60°C).
[0028] In step 2 of this embodiment, the air supply temperature for spray drying is 180-185°C.
[0029] The amount of auxiliary materials used in step three of this embodiment is that the dry paste powder is added with auxiliary materials to prepare 3.2 grams of medicinal pieces per gram of particles.
[0030] The auxiliary material of this embodiment is any one of corn starch, dextrin and maltodextrin.
[0031] Example 1. The present invention provides a kudzu vine root formula granule and a preparation method thereof, comprising the following steps: Step 1, extracting and concentrating the Pueraria lobata medicinal material slices to obtain a concentrated solution; Step 2, spray-drying the concentrated solution obtained in step 1 into a dry paste powder; Step 3: Add the auxiliary materials to the dry paste powder in step 2, mix evenly, and dry granulate to obtain the kudzu vine formula granules.
[0032] The auxiliary materials are added to the dry paste powder of step 2, and 5% of the total amount of the dry paste powder of step 2 is added to the chitosan modified montmorillonite agent; The preparation method of chitosan modified montmorillonite agent is as follows: S01: Add 10% sodium alginate aqueous solution to 5 times the mass fraction of 2% hydrochloric acid solution and stir evenly, then add 1% of the total amount of montmorillonite glycolic acid and 2% of the mass fraction of 5% chitosan aqueous solution, stir evenly to obtain a modifier; S02: The modifier of S01 and montmorillonite were mixed in a weight ratio of 1:10, and subjected to ball milling modification. The ball milling speed was 1000 r / min, and the ball milling time was 20 min. After the ball milling was completed, the mixture was washed with water and dried. S03: The ball-milled montmorillonite is heat-treated at 120°C for 5 minutes, then cooled to 40°C at a rate of 1°C / min, and then added to the modifier of S01 and stirred for modification. The stirring speed is 500r / min and the stirring time is 1h. After stirring, wash with water and dry, the chitosan-modified montmorillonite agent can be obtained.
[0033] The extraction and concentration in step 1 of this embodiment includes the following steps: a1, soaking the Pueraria lobata medicinal material slices in water, heating for the first extraction, and then filtering to obtain filtrate I and filter residue; a2, adding water to the residue in a1, heating it for a second extraction, and filtering it to obtain filtrate II; a3. Combine the filtrate I and the filtrate II, and concentrate under reduced pressure and low temperature to obtain a concentrate.
[0034] In a1 of this embodiment, the mass ratio of the Pueraria lobata medicinal material slices to water is 1:5, the mass ratio of the filter residue to water in a2 is 1:3, and the soaking time in a1 is 15 minutes.
[0035] In a1 and a2 of this embodiment, the heating temperature is 80° C., and the extraction time is 0.5 h.
[0036] The filtration mesh numbers in a1 and a2 of this embodiment are both 200 meshes.
[0037] The reduced pressure concentration process of this embodiment is as follows: the concentration temperature is less than 65°C, the vacuum degree is ≥-0.08mpa, and the concentration is performed to a relative density of 1.08 (60°C).
[0038] In step 2 of this embodiment, the air supply temperature for spray drying is 180°C.
[0039] The amount of auxiliary materials used in step three of this embodiment is that the dry paste powder is added with auxiliary materials to prepare 3.2 grams of medicinal pieces per gram of particles.
[0040] The auxiliary material of this embodiment is corn starch.
[0041] Example 2. The present invention provides a kudzu vine root formula granule and a preparation method thereof, comprising the following steps: Step 1, extracting and concentrating the Pueraria lobata medicinal material slices to obtain a concentrated solution; Step 2, spray-drying the concentrated solution obtained in step 1 into a dry paste powder; Step 3: Add the auxiliary materials to the dry paste powder in step 2, mix evenly, and dry granulate to obtain the kudzu vine formula granules.
[0042] The auxiliary materials are added to the dry paste powder of step 2, and 10% of the total amount of the dry paste powder of step 2 is added to the chitosan modified montmorillonite agent; The preparation method of chitosan modified montmorillonite agent is as follows: S01: Add 10% sodium alginate aqueous solution to 10 times the mass fraction of 2% hydrochloric acid solution and stir evenly, then add 5% of the total amount of montmorillonite glycolic acid and 5% of the mass fraction of 5% chitosan aqueous solution, stir evenly to obtain a modifier; S02: The modifier of S01 and montmorillonite were mixed in a weight ratio of 1:10, and subjected to ball milling modification. The ball milling speed was 1500r / min, and the ball milling time was 30min. After the ball milling was completed, the mixture was washed with water and dried. S03: The ball-milled montmorillonite is heat-treated at 130°C for 10 min, then cooled to 45°C at a rate of 3°C / min, and then added to the modifier of S01 and stirred for modification. The stirring speed is 600r / min and the stirring time is 2h. After stirring, it is washed with water and dried to obtain the chitosan-modified montmorillonite agent.
[0043] The extraction and concentration in step 1 of this embodiment includes the following steps: a1, soaking the Pueraria lobata medicinal material slices in water, heating for the first extraction, and then filtering to obtain filtrate I and filter residue; a2, adding water to the residue in a1, heating it for a second extraction, and filtering it to obtain filtrate II; a3. Combine the filtrate I and the filtrate II, and concentrate under reduced pressure and low temperature to obtain a concentrate.
[0044] In a1 of this embodiment, the mass ratio of the Pueraria lobata medicinal material slices to water is 1:9, the mass ratio of the filter residue to water in a2 is 1:7, and the soaking time in a1 is 60 min.
[0045] In a1 and a2 of this embodiment, the heating temperature is 100° C., and the extraction time is 1.5 h.
[0046] The filtration mesh numbers in a1 and a2 of this embodiment are both 200 meshes.
[0047] The reduced pressure concentration process of this embodiment is as follows: the concentration temperature is less than 65°C, the vacuum degree is ≥-0.08mpa, and the concentration is performed to a relative density of 1.13 (60°C).
[0048] In step 2 of this embodiment, the air supply temperature for spray drying is 185°C.
[0049] The amount of auxiliary materials used in step three of this embodiment is that the dry paste powder is added with auxiliary materials to prepare 3.2 grams of medicinal pieces per gram of particles.
[0050] The auxiliary material of this embodiment is maltodextrin.
[0051] Example 3. The present invention provides a kudzu vine root formula granule and a preparation method thereof, comprising the following steps: Step 1, extracting and concentrating the Pueraria lobata medicinal material slices to obtain a concentrated solution; Step 2, spray-drying the concentrated solution obtained in step 1 into a dry paste powder; Step 3: Add the auxiliary materials to the dry paste powder in step 2, mix evenly, and dry granulate to obtain the kudzu vine formula granules.
[0052] The auxiliary materials are added to the dry paste powder of step 2, and 7.5% of the total amount of the dry paste powder of step 2 is added to the chitosan modified montmorillonite agent; The preparation method of chitosan modified montmorillonite agent is as follows: S01: Add 10% sodium alginate aqueous solution to 7.5 times the mass fraction of 2% hydrochloric acid solution and stir evenly, then add 3% of the total amount of montmorillonite glycolic acid and 3.5% of the mass fraction of 5% chitosan aqueous solution, stir evenly, and obtain a modifier; S02: The modifier of S01 and montmorillonite were mixed in a weight ratio of 1:10, and subjected to ball milling modification. The ball milling speed was 1250 r / min, and the ball milling time was 25 min. After the ball milling was completed, the mixture was washed with water and dried. S03: The ball-milled montmorillonite was heat treated at 125°C for 7.5 min, then cooled to 42.5°C at a rate of 2°C / min, and then added to the modifier of S01 and stirred for modification. The stirring speed was 550 r / min and the stirring time was 1.5 h. After stirring, the mixture was washed with water and dried to obtain the chitosan-modified montmorillonite agent.
[0053] The extraction and concentration in step 1 of this embodiment includes the following steps: a1, soaking the Pueraria lobata medicinal material slices in water, heating for the first extraction, and then filtering to obtain filtrate I and filter residue; a2, adding water to the residue in a1, heating it for a second extraction, and filtering it to obtain filtrate II; a3. Combine the filtrate I and the filtrate II, and concentrate under reduced pressure and low temperature to obtain a concentrate.
[0054] In a1 of this embodiment, the mass ratio of the Pueraria lobata medicinal material slices to water is 1:7, the mass ratio of the filter residue to water in a2 is 1:5, and the soaking time in a1 is 30 minutes.
[0055] In a1 and a2 of this embodiment, the heating temperature is 90° C., and the extraction time is 1 hour.
[0056] The filtration mesh numbers in a1 and a2 of this embodiment are both 200 meshes.
[0057] The reduced pressure concentration process of this embodiment is as follows: the concentration temperature is less than 65°C, the vacuum degree is ≥-0.08mpa, and the concentration is performed to a relative density of 1.11 (60°C).
[0058] In step 2 of this embodiment, the air supply temperature for spray drying is 182°C.
[0059] The amount of auxiliary materials used in step three of this embodiment is that the dry paste powder is added with auxiliary materials to prepare 3.2 grams of medicinal pieces per gram of particles.
[0060] The auxiliary material of the present embodiment is dextrin.
[0061] Comparative Example 1. The difference from Example 3 is that only one extraction is performed.
[0062] Comparative Example 2. The difference from Example 3 is that auxiliary materials are added during spray drying.
[0063] Comparative Example 3. The difference from Example 3 is that the air supply temperature is 170°C.
[0064] Comparative Example 4. The difference from Example 3 is that no chitosan-modified montmorillonite agent is added.
[0065] Comparative Example 5. The difference from Example 3 is that the chitosan-modified montmorillonite agent is replaced by montmorillonite.
[0066] The performance tests of the products prepared in Examples 1-3 and Comparative Examples 1-5 are as follows: Instruments and reagents Instruments: JJ1000 electronic balance, TC20K-H electronic balance, RE-6000A rotary evaporator, spray dryer, round bottom flask, electric heating mantle, etc.
[0067] Test drugs: Pueraria lobata medicinal materials (Examples 1-3 and Comparative Examples 1-3), corn starch, dextrin, maltodextrin, drinking water, purified water, Experimental methods Take 300 g of Puerariae Radix Pall. Soak in water for 30 minutes. Reflux extract twice for 1 hour each time. Add 7 times the amount of water for the first time and 5 times the amount of water for the second time. Filter and combine the filtrates. Concentrate the filtrates under reduced pressure (temperature 65°C, vacuum degree ≥-0.08mpa) to a relative density of 1.08-1.13 (60°C). Take samples (1 / 10 of the total samples) to detect the yield of dry paste. The remaining samples are freeze-dried into dry paste, crushed into fine powder, added with dextrin auxiliary materials, mixed evenly, and dry granulated to make 84.4g granules. The results of the content submitted for inspection are shown in the following table.
[0068]
[0069] From Examples 1-3, the yield data of each process of the kudzu vine formula granules are stable and the quality is controllable, indicating that the process meets the requirements. As can be seen from Comparative Examples 1-5, the use of chitosan-modified montmorillonite agent can significantly optimize the performance effect of the product. At the same time, when montmorillonite is used instead, the performance improvement of the product is poor. Only the chitosan-modified montmorillonite agent prepared by the method of the present invention has the most significant performance effect.
[0070] In addition, it should be understood that although the present specification is described according to implementation modes, not every implementation mode contains only one independent technical solution. This description of the specification is only for the sake of clarity. Those skilled in the art should regard the specification as a whole. The technical solutions in each embodiment may also be appropriately combined to form other implementation modes that can be understood by those skilled in the art.
Claims
1. A method for preparing kudzu root formula granules, characterized in that: The following steps are involved: Step 1, extracting and concentrating the Pueraria lobata medicinal material slices to obtain a concentrated solution; Step 2, spray-drying the concentrated solution obtained in step 1 into a dry paste powder; Step 3: Add the auxiliary materials to the dry paste powder in step 2, mix evenly, and dry granulate to obtain the kudzu vine formula granules.
2. The method for preparing the kudzu vine formula granules according to claim 1, characterized in that: The extraction and concentration in step 1 comprises the following steps: a1, soaking the Pueraria lobata medicinal material slices in water, heating for the first extraction, and then filtering to obtain filtrate I and filter residue; a2, adding water to the residue in a1, heating it for a second extraction, and filtering it to obtain filtrate II; a3. The filtrate I and the filtrate II are combined and concentrated under reduced pressure and low temperature to obtain a concentrated solution.
3. The method for preparing the kudzu vine formula granules according to claim 2, characterized in that: The mass ratio of the Pueraria lobata medicinal material slices to water in a1 is 1:5-9, the mass ratio of the filter residue to water in a2 is 1:3-7, and the soaking time in a1 is 15-60 minutes.
4. The method for preparing the kudzu vine formula granules according to claim 2, characterized in that: The heating temperature in a1 and a2 is 80-100° C., and the two extraction times are 0.5-1.5 h.
5. The method for preparing the kudzu vine formula granules according to claim 2, characterized in that: The filtration mesh numbers in a1 and a2 are both 200 meshes.
6. The method for preparing the kudzu vine formula granules according to claim 2, characterized in that: The reduced pressure concentration process is as follows: the concentration temperature is less than 65°C, the vacuum degree is ≥-0.08mpa, and the concentration is to a relative density of 1.08-1.13 (60°C).
7. The method for preparing the kudzu vine formula granules according to claim 1, characterized in that: The air supply temperature of the spray drying in the step 2 is 180-185° C.; the amount of auxiliary materials used in the step 3 is such that the dry paste powder is added with auxiliary materials to prepare 3.2 grams of the medicinal material per gram of particles.
8. The method for preparing the kudzu vine formula granules according to claim 1, characterized in that: The auxiliary materials are added to the dry paste powder in step 2, and 5-10% of the total amount of the dry paste powder in step 2 is added to the chitosan modified montmorillonite agent; The preparation method of chitosan modified montmorillonite agent is as follows: S01: adding a 10% sodium alginate aqueous solution to 5-10 times the mass fraction of a 2% hydrochloric acid solution and stirring evenly, then adding 1-5% of the total amount of montmorillonite glycolic acid and 2-5% of a 5% chitosan aqueous solution by mass fraction and stirring evenly to obtain a modifier; S02: The modifier of S01 and montmorillonite are mixed in a weight ratio of 1:10, and subjected to ball milling modification treatment. The ball milling speed is 1000-1500r / min, and the ball milling time is 20-30min. After the ball milling is completed, the mixture is washed with water and dried; S03: The ball-milled montmorillonite is heat-treated at 120-130°C for 5-10 minutes, then cooled to 40-45°C at a rate of 1-3°C / min, and then added to the modifier of S01 and stirred for modification. The stirring speed is 500-600r / min and the stirring time is 1-2h. After stirring, wash with water and dry to obtain the chitosan-modified montmorillonite agent.
9. The method for preparing the kudzu vine formula granules according to claim 1, characterized in that: The auxiliary material is any one of corn starch, dextrin and maltodextrin.
10. A kudzu root formula granule, characterized in that: Prepared by the preparation method according to any one of claims 1 to 9.