Suspending agent containing mepiquat chloride. Prohexadione calcium and preparation and application thereof

Abstract

The invention relates to the technical field of plant growth regulation, in particular to the field of IPC A01N 37, and more particularly relates to a suspending agent containing mepiquat chloride. Prohexadione calcium as well as preparation and application of the suspending agent. The water-soluble suspending agent comprises the following components in percentage by weight: 5-20% of prohexadione calcium, 1-8% of mepiquat chloride, 3-10% of a dispersing agent, 1-6% of a synergist, 4-10% of an anti-freezing agent, 0.5-3% of a thickening agent, 0.5-3% of an auxiliary agent and the balance of reverse osmosis water. The formula product has relatively strong surface wetting power and can keep a good wetting effect, so that the liquid medicine is easy to spread on the surface of a leaf, the loss of the liquid medicine is reduced, and the pesticide effect is exerted; accelerated heat storage test, cold storage test and freeze thawing test show that the formula sample has excellent stability, and each index is basically unchanged before and after heat storage.

Description

Technical Field

[0001] The invention relates to the technical field of plant growth regulation, in particular to the field of IPCA01N 37, and more specifically to a suspension containing mepiquat-prohexadione-calcium and the preparation and application thereof. Background Art

[0002] The mechanism of action of calcium oxadiazine is to control the vigorous growth of crops and plant morphology by reducing the content of gibberellins, effectively reducing the height of plants and making the internodes at the base strong. Mepiquat is a very good crop growth regulator, which can effectively promote the growth and development of crops, improve the fruit setting rate and fruiting rate of crops, increase the fruit yield of crops, and double the economic benefits. In order to increase the yield of crops, plant growth regulators are usually used for growth control. Although the above plant growth regulators have a good regulating effect on crops when used alone, the application of a single plant growth regulator is relatively narrow. By rationally compounding calcium oxadiazine and mepiquat, the problem of poor regulating effect of existing plant growth regulators on crops when used alone is solved, but there are still stability-related problems that need to be solved urgently.

[0003] Chinese invention patent CN 116267938A discloses a growth regulating composition containing prohexadione calcium and mepiquat. By rationally compounding prohexadione calcium and mepiquat, the usage of prohexadione calcium and mepiquat can be reduced while achieving the same excellent effect. In addition, the regulation range can be expanded, the efficacy and selectivity can be improved, the cost of medication can be relatively reduced, and the residual effect period of the agent can be shortened to avoid drug damage and ensure crop safety. However, no research on the stability of the dosage form is involved. Summary of the invention

[0004] The first aspect of the present invention provides a suspension containing mepiquat-prohexadione-calcium. The components include, by weight percentage, 5-20% of prohexadione-calcium, 1-8% of mepiquat-prohexadione, 3-10% of dispersant, 1-6% of synergist, 4-10% of antifreeze agent, 0.5-3% of thickener, 0.5-3% of auxiliary agent, and the balance is made up of reverse osmosis water.

[0005] Preferably, the components include, by weight percentage: 5-15% of prohexadione calcium, 1-5% of mepiquat, 3-8% of dispersant, 1-5% of synergist, 4-8% of antifreeze agent, 0.5-2% of thickener, 0.5-2% of auxiliary agent, and the balance is made up by reverse osmosis water.

[0006] The weight ratio of the prohexadione calcium to mepiquat is (1.5-4):1.

[0007] The present application has found that by limiting the weight ratio of prohexadione calcium to mepiquat to (1.5-4):1, the efficacy of the composition can be maximized. After the two are compounded, the usage amounts of prohexadione calcium and mepiquat can be reduced while maintaining the effects of each being used alone. In addition, the adjustment range can be expanded, the efficacy can be improved, the cost of medication can be relatively reduced, the residual effect period of the agent can be shortened, the injury of the agent can be avoided, and the crops can be made safe.

[0008] Preferably, the weight ratio of prohexadione calcium to mepiquat is (2-3):1.

[0009] More preferably, the weight ratio of prohexadione-calcium to mepiquat is 2.5:1.

[0010] The dispersant includes a cationic polycarboxylic acid dispersant and a polyarylphenol polyether modified dispersant.

[0011] Preferably, the cationic polycarboxylic acid dispersant includes at least one of the following models of Jiangsu Qingyu Chemical Technology Co., Ltd.: SP-DF2238, SP-SC3275 and SP-2836.

[0012] Further preferably, the cationic polycarboxylic acid dispersant includes SP-SC3275 produced by Jiangsu Qingyu Chemical Technology Co., Ltd.

[0013] Preferably, the polyarylphenol polyether modified dispersant includes SP-SC29 produced by Jiangsu Qingyu Chemical Technology Co., Ltd.

[0014] The decomposition rate of effective active ingredients of calcium cyclohexane in the aqueous phase is high, and calcium salts are prone to flocculation after long-term storage. During hot storage, oxidation discoloration and adhesion to the bottle wall may occur, resulting in product discoloration and wall adhesion problems. Conventional sulfates, sulfonates, and polycarboxylates cannot solve the above-mentioned problems well, or cannot solve the problems encountered with a small amount. This application study found that the use of cationic polycarboxylic acid dispersants and polyarylphenol polyether modified dispersants can improve the adaptability of the suspension to different water qualities or solute solutions, improve physical stability, and can be diluted with tap water, standard hard water, three times standard hard water, and 30 times potassium dihydrogen phosphate aqueous solution. The dilution can be kept free of stratification, crystallization, floccules, etc., and can be adapted to a variety of water qualities and has excellent mixed use effects. In particular, the selection of SP-SC3275 and SP-SC29 can effectively improve the sand milling efficiency and facilitate the thermal storage stability of the system. The polymer amphiphilic dispersant SP-SC29 has a similar twin structure. Under the action of external forces such as colloid milling or high-speed shear force, the thickness of the double electric layer on the particle surface is increased. The polycarboxylate dispersant SP-SC3275 is a weakly cationic polycarboxylate. In addition to the high-efficiency dispersion stability of traditional polymer polycarboxylates, due to the ionic properties of prohexadione calcium, SP-SC3275 with weakly cationic properties is more tightly encapsulated with the prohexadione calcium original drug particles, which is more conducive to the stability of the product. The combination of the two has a synergistic dispersion effect, effectively controlling the increase in product particle size. With the aid of grinding technology, the product can also be sand-ground to nanometer scale to make a nano-preparation.

[0015] The synergist includes at least one of SP-6535, silicone, and TM-10.

[0016] Preferably, the synergist comprises SP-6535.

[0017] The weight ratio of the cationic polycarboxylic acid dispersant to the polyarylphenol polyether modified dispersant is (1-4):1.

[0018] Preferably, the weight ratio of the cationic polycarboxylic acid dispersant to the polyarylphenol polyether modified dispersant is (1-3):1.

[0019] Further preferably, the weight ratio of the cationic polycarboxylic acid dispersant to the polyarylphenol polyether modified dispersant is 2:1.

[0020] Preferably, the synergist accounts for 1-3wt% in the suspension concentrate of mepiquat-prohexadione-calcium.

[0021] The present application has found that the proportion of the synergist in the suspension of mepiquat-prohexadione-calcium is 1-3wt%, and the synergist is SP-6535, which can further improve the efficacy of the suspension.

[0022] The auxiliary agent includes a defoaming agent and / or a preservative.

[0023] Preferably, the auxiliary agent includes a defoaming agent and a preservative.

[0024] Preferably, the defoaming agent comprises a silicone defoaming agent.

[0025] Further preferably, the defoaming agent includes at least one of defoaming agent DF-830, defoaming agent 1572, and defoaming agent DF-1108.

[0026] More preferably, the defoaming agent includes defoaming agent 1572.

[0027] The preservative includes at least one of paraben preservatives, MIT20, isothiazolinone, and sodium benzoate.

[0028] Preferably, the preservative comprises MIT20.

[0029] Preferably, the antifreeze agent includes at least one of ethylene glycol, propylene glycol, glycerol and urea.

[0030] The thickener includes at least one of magnesium aluminum silicate, sodium benzoate, xanthan gum, polyvinyl alcohol, and sodium alginate.

[0031] Preferably, the thickener comprises magnesium aluminum silicate and xanthan gum, and the weight ratio of magnesium aluminum silicate to xanthan gum is (3-8):1.

[0032] Further preferably, the weight ratio of magnesium aluminum silicate to xanthan gum is (3-5):1.

[0033] The second aspect of the present invention provides a method for preparing a suspension containing mepiquat-prohexadione-calcium, comprising the following steps:

[0034] S1, adding prohexadione calcium, a dispersant, an antifreeze agent, a thickener, an additive and reverse osmosis water, dispersing them uniformly and then grinding them to obtain a mixture;

[0035] S2, add the synergist and mepiquat to the mixture, and disperse them evenly to obtain.

[0036] Use 1-1.5 mm sand mill beads to prepare conventional suspensions, and use 0.1-0.5 mm sand mill beads to prepare nanosuspensions.

[0037] The D90 particle size of the mixture is 0.2-4 microns.

[0038] Preferably, the D90 particle size of the mixture is 0.2-3 microns.

[0039] Further preferably, the D90 particle size of the mixture is 0.2-0.5 microns.

[0040] Since mepiquat can be completely dissolved in water, the present application has found that when the sample particle size D90 is controlled at about 0.2-2 microns during the sand-grinding step of calcium cyclohexane, and then mepiquat original drug is added, the prepared sample is no longer a milky white suspension in the normal state under the condition of 500 times use concentration dilution, but a nano-scale suspension with a slightly blue fluorescence, and the diluted liquid sample can be kept free of stratification, crystallization, precipitation, and floccules for 24 hours. The various indicators of the sample before and after hot storage show that it is significantly better than the traditional suspension, and the particle size D90 does not increase too much after the accelerated hot storage. At the same time, the nano-scale original drug particles can more easily penetrate the surface of the plant leaves, and after being absorbed, it is easier to conduct to the roots, stems and other parts of the plant to exert the efficacy, and it has a good ability to control the particle size, and it is realistic to achieve large-scale production of nano-scale.

[0041] The third aspect of the present invention provides an application of a suspension containing mepiquat-prohexadione-calcium for cotton growth regulation.

[0042] Beneficial Effects

[0043] 1. By limiting the weight ratio of prohexadione calcium to mepiquat to (1.5-4):1, the efficacy of the suspension can be improved, the cost of the drug can be reduced, and the residual effect period of the drug can be shortened, thereby avoiding drug damage and ensuring crop safety.

[0044] 2. The combination of SP-SC3275 and SP-SC29 can effectively improve the dispersion efficiency and benefit the thermal storage stability of the system.

[0045] 3. The proportion of the synergist in the suspension of mepiquat-calcium prohexadione is 1-3wt%, and the synergist is SP-6535, which further improves the efficacy of the suspension and further improves the heat storage stability.

[0046] 4. Through a specific preparation method, the D90 particle size of the mixture is 0.2-2 microns, and the diluted liquid sample can be kept free of stratification, crystallization, precipitation, and floccules for 24 hours, and has a good ability to control the particle size, which has the realistic possibility of realizing large-scale production of nano-scale.

[0047] 5. The use of cationic polycarboxylic acid dispersant and polyarylphenol polyether modified dispersant can improve the adaptability of the suspension to different water qualities or solute solutions and improve physical stability. After dilution with tap water, standard hard water, three times standard hard water, and 30 times potassium dihydrogen phosphate aqueous solution, the dilution can be kept free of stratification, crystallization, floccules, etc. It can be adapted to a variety of water qualities and has excellent mixing effect. BRIEF DESCRIPTION OF THE DRAWINGS

[0048] Figure 1 This is the state of the sample after hot storage in Comparative Example 1.

[0049] Figure 2 This is the state of the sample after hot storage in Comparative Example 2.

[0050] Figure 3 This is the state of the sample after hot storage in Comparative Example 3.

[0051] Figure 4 This is the state of the sample after hot storage in Comparative Example 6.

[0052] Figure 5 This is the state of the sample after hot storage in Comparative Example 7.

[0053] Figure 6 Dilute the 30-fold potassium dihydrogen phosphate solution of Example 2 for 4 hours

[0054] Figure 7 Diluted with nanometer standard hard water in Example 2 for 24 hours

[0055] Figure 8 Example 2 nanometer dilute standard hard water release 4h DETAILED DESCRIPTION

[0056] Example 1, Comparative Examples 1-7

[0057] A suspension concentrate containing mepiquat-calcium prohexadione, the components of which are shown in Table 1 by weight percentage.

[0058] Table 1

[0059]

[0060]

[0061] A method for preparing a suspension containing mepiquat-calcium prohexadione, wherein Example 1 comprises the following steps:

[0062] S1, adding calcium prohexadione, dispersant, antifreeze, thickener, additive and reverse osmosis water into a sand mill, using a FJ300-SH shearing machine to adjust the speed to 8000 r / min, shearing for 5 minutes, preliminarily dispersing the above materials, adding sand milling beads with a size of 1.2 mm into the above sand milling tank, using a laboratory vertical small sand mill, continuously sand milling for 3 hours, controlling the particle size D90 at 3 microns, to obtain a mixture;

[0063] S2, add the synergist and mepiquat to the mixture, and continue to disperse for 5 minutes.

[0064] Comparative Examples 1-7 are the following steps:

[0065] S1, adding calcium prohexadione, dispersant, antifreeze, thickener, additive and reverse osmosis water into a sand mill, using a FJ300-SH shearing machine to adjust the speed to 8000 r / min, shearing for 5 minutes, preliminarily dispersing the above materials, adding sand milling beads with a size of 1.2 mm into the above sand milling tank, using a laboratory vertical small sand mill, continuously sand milling for 3 hours, controlling the particle size D90 at 3 microns, to obtain a mixture;

[0066] S2, add methylpiperidinium to the mixture and continue to disperse for 5 minutes to obtain.

[0067] Example 2

[0068] The specific implementation mode is the same as that of embodiment 1, except that:

[0069] S1, adding calcium prohexadione, dispersant, antifreeze, thickener, additive and reverse osmosis water into a sand mill, using a FJ300-SH shearing machine to adjust the speed to 8000 r / min, shearing for 5 minutes, preliminarily dispersing the above materials, adding sand milling beads with a size of 0.3 mm into the above sand milling tank, using a laboratory vertical small sand mill, continuously sand milling for 10.0 hours, controlling the particle size D90 at 0.3 microns, to obtain a mixture;

[0070] S2, add the synergist and mepiquat to the mixture, and continue to disperse for 5 minutes.

[0071] Performance Testing Methods

[0072] 1. The indoor combined toxicity test of mepiquat and prohexadione calcium was carried out according to the test criteria for indoor biological activity determination of plant regulators (NY / T 2061.2-2011) and (NY / T 2061.5-2016). The regulating effects of mepiquat and prohexadione calcium and their different ratios on cotton growth are shown in Table 2, and the combined effects of mepiquat and prohexadione calcium in different ratios on cotton growth (Gowing method) are shown in Table 3.

[0073] 2. Field experiment: Comply with the "Quality Management Standards for Pesticide Registration Tests", "Guidelines for Pesticide Field Efficacy Tests" GB / T17980.134-2004, and SOP-TM-068a "Cotton Growth Regulation Test".

[0074] Test reagents:

[0075] Test drug, 14% prohexadione calcium-mepiridone suspension, Shanghai Yuelian Biotechnology Co., Ltd.

[0076] Control drugs: 5% prohexadione calcium effervescent granules, Anyang Quanfeng Biotechnology Co., Ltd.; 98% mepiquat soluble powder, Sichuan Runer Technology Co., Ltd.

[0077] Application method and water consumption: Spray, water consumption per hectare is about 525 liters.

[0078] Purpose of the test: To verify the effect of the test agent on regulating cotton growth and its safety to crops, and to provide a field efficacy basis for the registration of the agent.

[0079] 1 Test conditions

[0080] 1.1 Crops and targets: Crops / cotton / Hongyuza No. 5

[0081] Target / regulate growth

[0082] 1.2 Experimental conditions: The experiment was conducted in the cotton field of Xiaoba Village, Heilong Town, Qingshen County, Meishan City, Sichuan Province from June 11, 2023 to October 30, 2023. Cotton variety: Hongyuza No. 5, sown on April 8, 2023, with about 1,200 plants per mu. Growth period: bud stage, with white radish as the previous crop. The field is brown-gray semi-sandy soil with medium fertility level, pH value of 5.9, and organic matter content of about 2.0%.

[0083] 2 Experimental design and arrangement

[0084] 2.1 Pharmacy

[0085] 2.1.1 Test Agents

[0086] 14% Prohexadione Calcium Mepiquat Suspension (Shanghai Yuelian Biotechnology Co., Ltd.)

[0087] Basic information of active ingredients:

[0088] Chinese name: prohexadione calcium, English name: prohexadione calcium, CAS registration number: 127277-53-6, molecular formula: C10H10O5Ca, molecular weight: 250.3. The above information comes from the 2nd edition of the New Pesticide Handbook and the Pesticide Analysis Handbook.

[0089] (Sample number: TSN2023495, gross weight: 151g, appearance / color: light brown opaque liquid, production date: 2022.3.6, batch number: 2022030601, validity period: 2 years, sample date: 2023.3.30, storage conditions: storage at room temperature.) The above information is provided by the client.

[0090] 2.1.2 Control Drugs

[0091] 5% Prohexadione Calcium Effervescent Granules (Anyang Quanfeng Biotechnology Co., Ltd.)

[0092] (Sample number: CSN002023448, pesticide registration certificate number: PD20180369, gross weight: 20g, appearance / color: granular solid, production date: 2019.3.12, batch number: 20190312, validity period: 2 years, sample date: 2023.3.30, storage conditions: storage at room temperature.) The above information is provided by the client.

[0093] 98% mepiquat soluble powder (Sichuan Runer Technology Co., Ltd.)

[0094] (Sample number: CSN012023195, pesticide registration number: PD20131453, gross weight: 13g, appearance / color: solid, production date: 2019.11.12, validity period: 2 years, sample date: 2023.4.2, storage conditions: storage at room temperature.) The above information is obtained from the product label.

[0095] Table 1: Results of a test on regulating cotton growth using 14% prohexadione-calcium methylpiperidinium suspension concentrate.

[0096] Table 2: Results of the test on regulating cotton growth by 14% prohexadione-calcium and mepiquat suspension concentrate.

[0097] Table 3: Results of the measurement of cotton growth quality regulated by 14% prohexadione-calcium methylpiperidinium suspension concentrate.

[0098] 3. Stability test: After room temperature, hot storage and cold storage, the suspension rate of prohexadione calcium, the suspension rate of mepiquat, pH, persistent foaming (after 1 min), and wet sieve test (through 75 μm test sieve) were tested. The test results are shown in Table 7-13.

[0099] Among them, reference is made to GB / T 19136-2021 method for determining thermal storage stability of pesticides, GB / T 19137-2003 method for determining low temperature stability of pesticides, GB / T 28137 method for determining persistent foaming of pesticides, GB / T14825-2023 method for determining suspension rate of pesticides, GB / T 1601 method for determining pH value of pesticides, and the wet sieve test is determined according to GB / T 16150-1995.

[0100] like Figure 1 As shown, the particle size D90 of Comparative Example 1 increased from 3.2 μm to 10.3 μm after hot storage, and there were a large number of particles in the 75 μm wet screen.

[0101] like Figure 2 As shown, the particle size D90 of Comparative Example 2 increased from 3.1 μm to 6.5 μm after hot storage, and there was a small amount of particulate matter in the 75 μm wet screen.

[0102] like Figure 3 As shown, the experimental sample of Comparative Example 3 was paste-like after hot storage.

[0103] In comparative example 4, the auxiliary agent KY-518 is a compound of anionic surfactant and polyether surfactant. The viscosity of the experimental sample after sand grinding reaches about 2500 mPa.s, and the viscosity of the experimental sample after hot storage reaches about 3100 mPa.s, which exceeds the control range of 1600-2000 mPa.s (rotor No. 2, 6RPM), and the risk of paste formation is high.

[0104] like Figure 4 As shown, after hot storage, the sample of Comparative Example 6 showed pseudoplasticity on the surface, and the suspension returned to normal after shaking.

[0105] like Figure 5 As shown, the sample of Comparative Example 7 dehydrated and stratified by about 50% after hot storage.

[0106] like Figure 6-8 As shown, after being diluted with standard hard water for 4 hours, standard hard water for 24 hours, and 30 times potassium dihydrogen phosphate aqueous solution, the diluted liquid can be kept free of stratification, crystallization, floccules, etc., and can be adapted to a variety of water qualities and has excellent mixing effect.

[0107] Performance test data

[0108] Table 2

[0109]

[0110]

[0111] Table 3

[0112]

[0113]

[0114] From the results in Tables 2 and 3, it can be seen that the plant height growth inhibition rates 15 days after treatment with the test agent mepiquat at 15.56 mg / L, 23.33 mg / L, 35 mg / L, 52.5 mg / L and 78.75 mg / L were 3.00%, 5.04%, 6.97%, 9.10% and 11.09%, respectively; the plant height inhibition rates 15 days after treatment with 50.64 mg / L, 60.76 mg / L, 72.91 mg / L, 87.5 mg / L and 105 mg / L were 4.08%, 5.11%, 6.04%, 7.05% and 9.02%, respectively. After the two were mixed in pairs, the Gowing method was used to evaluate their combined action type. It showed that the E-E0 value of the treatment with mepiquat + calcium prohexadione 35mg / L+87.5mg / L was the largest in the plant height inhibition rate 15 days after the drug application, which was an additive effect. The inhibitory effect on the growth of cotton plant height was significant. The two had a certain additive effect when the ratio was 1:2.5. The yield increase rates of the experimental agent mepiquat 15.56mg / L, 23.33mg / L, 35mg / L, 52.5mg / L and 78.75mg / L were 2.11%, 3.22%, 4.93%, 6.20% and 7.92%; the yield increase rates of prohexadione calcium 50.64mg / L, 60.76mg / L, 72.91mg / L, 87.5mg / L and 105mg / L were 1.48%, 1.96%, 3.98%, 5.04% and 6.07%. After the two were mixed, the Gowing method was used to evaluate the type of joint action. It was found that the E-E0 value of mepiquat + prohexadione calcium 35mg / L + 87.5mg / L was greater than 10%, which was a synergistic effect, and the yield increase effect on cotton single boll weight was significant. The two had a certain synergistic effect when the ratio was 1:2.5.

[0115] The test results show that when the ratio of mepiquat to prohexadione-calcium is 1:2.5, it can inhibit the vigorous growth of plants, increase the weight of single boll, and significantly regulate the growth and increase the yield of cotton. Enterprises can consider processing the preparation according to this ratio to regulate the growth of cotton and increase the yield. Observation during the test process shows that the two agents and their respective ratios and dosages are safe for the growth of the test cotton and there is no phytotoxicity.

[0116] Table 4

[0117]

[0118] Table 5

[0119]

[0120] Table 6

[0121]

[0122]

[0123] Table 3-5 shows that 8, 12, 16, and 24 ml of 14% prohexadione calcium·mepiquat suspension were used per mu to regulate cotton growth, and the plant height inhibition rate was 8.2%, 10.2%, 10.7%, and 13.5%, the fruit branch length regulation rate was 18.1%, 12.6%, 10.6%, and 9%, the internode length inhibition rate was 13.4%, 14.6%, 18.3%, and 20.7%, the cotton boll number regulation rate was 6.7%, 13.5%, 15.9%, and 13.9%, and the yield increase rate was 8.2%, 13.9%, 16%, and 13.6%. The control agent 5% prohexadione calcium effervescent granules were used per mu for 40 grams, and the plant height inhibition rate, fruit branch length regulation rate, internode length inhibition rate, cotton boll number regulation rate, and yield increase rate were 7.8%, 11.6%, 14.6%, 13%, and 13%, respectively. The control agent 98% mepiquat soluble powder 4g per mu had plant height inhibition rate, fruit branch length regulation rate, internode length inhibition rate, cotton boll number regulation rate, and yield increase rate of 24.2%, -22.4%, 35.4%, 4.8%, and 5.6%, respectively. The yield increase rate statistical data was analyzed by variance analysis, and the yield increase effect of the test agent 12, 16, and 24 ml per mu was equivalent and significantly higher than that of 8 ml per mu. Compared with the control agent, the yield increase effect of the test agent 12, 16, and 24 ml per mu was equivalent to that of the control agent 5% prohexadione calcium effervescent granules 40g per mu and significantly higher than that of 98% mepiquat soluble powder 4g per mu, and the yield increase effect of 8 ml per mu was equivalent to that of the control agent 98% mepiquat soluble powder 4g per mu. The test results show that 14% calcium prohexadione·mepiquat suspension can regulate cotton growth and has a significant regulatory effect on cotton growth. It has excellent effects such as inhibiting plant height and increasing cotton bolls. It can improve the plant structure of cotton plants, enhance lodging resistance, increase cotton boll weight, and significantly increase yield. The quality measurement results show that the test agent has no significant effect on cotton quality. During the test, cotton grew normally and no symptoms of pesticide damage were observed. 14% calcium prohexadione·mepiquat suspension can be used to regulate cotton growth.

[0124] According to the test results this year, the 14% calcium cyclamate-methylpiperidin suspension provided by Shanghai Yuelian Biotechnology Co., Ltd. is used to regulate cotton growth. The recommended dosage is 8-16 ml per mu (active ingredient 16.8-33.6 g / hectare). The first application is during the cotton budding stage, and the second application is about 15 days later. Add water and spray evenly.

[0125] Table 7

[0126]

[0127]

[0128] Table 8

[0129] Comparative Example-1 normal temperature Heat Storage Cold Storage Prohexadione calcium content, % 10.0 9.8 9.9 Suspension rate of prohexadione calcium, % 100 100 100 Mepiquat content, % 4.0 4.0 4.0 Mepiquat suspension rate, % 100 100 100 pH 6.8 6.4 6.7 Persistent foaming (after 1 min), mL 25 21 / Wet sieve test (through 75 μm test sieve), % 100 Large amount of particles precipitated 100 Particle size D90 / D97, μm 3.2 / 3.7 10.3 / 13.7 3.3 / 3.9

[0130] Table 9

[0131] Comparative Example-2 normal temperature Heat Storage Cold Storage Prohexadione calcium content, % 10.2 10.0 10.2 Suspension rate of prohexadione calcium, % 100 100 100 Mepiquat content, % 4.0 4.0 4.0 Mepiquat suspension rate, % 100 100 100 pH 6.8 6.5 6.6 Persistent foaming (after 1 min), mL 30 21 / Wet sieve test (through 75 μm test sieve), % 100 A small amount of crystals precipitated 100 Particle size D90 / D97, μm 3.1 / 3.9 6.5 / 8.3 2.8 / 3.9

[0132] Table 10

[0133] Comparative Example-4 normal temperature Heat Storage Cold Storage Prohexadione calcium content, % 10.0 10.0 10 Suspension rate of prohexadione calcium, % 100 100 100 Mepiquat content, % 4.0 4.0 4.0 Mepiquat suspension rate, % 100 100 100 pH 6.7 6.6 6.6 Persistent foaming (after 1 min), mL 45 37 / Wet sieve test (through 75 μm test sieve), % 100 99.9 100 Particle size D90 / D97, μm 3.2 / 3.7 3.4 / 4.1 3.2 / 3.8

[0134] Table 11

[0135]

[0136]

[0137] Table 12

[0138] Comparative Example-6 normal temperature Heat Storage Cold Storage Prohexadione calcium content, % 10.2 10.0 10.1 Suspension rate of prohexadione calcium, % 100 100 100 Mepiquat content, % 4.0 4.0 4.0 Mepiquat suspension rate, % 100 100 100 pH 6.6 6.4 6.5 Persistent foaming (after 1 min), mL 38 33 / Wet sieve test (through 75 μm test sieve), % 100 99 100 Particle size D90 / D97, μm 3.1 / 3.7 3.5 / 4.0 3.3 / 4.0

[0139] Table 13

[0140] Comparative Example-7 normal temperature Heat Storage Cold Storage Prohexadione calcium content, % 10.1 10.1 10.1 Suspension rate of prohexadione calcium, % 100 100 100 Mepiquat content, % 4.0 4.0 4.0 Mepiquat suspension rate, % 100 100 100 pH 6.7 6.5 6.5 Persistent foaming (after 1 min), mL 34 28 / Wet sieve test (through 75 μm test sieve), % 100 100 100 Particle size D90 / D97, μm 2.6 / 2.9 3.0 / 3.5 2.8 / 3.1

[0141] As shown in Tables 7-13, the adjuvants SP-SC3275 and SP-SC29 used in the agricultural adjuvant matching scheme used in the present invention have stable sources and stable performance. The special structure of the adjuvant can well maintain the dispersion of the prohexadione-calcium technical without precipitation. After accelerated hot storage test, cold storage test and freeze-thaw test, the formula sample has excellent stability, and various indicators are basically unchanged before and after hot storage.

[0142] When the prepared sample is diluted to 500 times the concentration, the diluted liquid is no longer a milky white suspension in the normal state, but a nano-scale suspension with a slightly blue fluorescence. The diluted liquid sample can be kept free of stratification, crystallization, precipitation, and floccules for 24 hours. All indicators of the sample before and after hot storage show that it is significantly better than traditional suspension agents.

Claims

1. A suspension containing mepiquat-calcium prohexadione, characterized in that: The components include, by weight percentage, 5-20% of prohexadione calcium, 1-8% of mepiquat, 3-10% of dispersant, 1-6% of synergist, 4-10% of antifreeze agent, 0.5-3% of thickener, 0.5-3% of auxiliary agent, and the balance is made up of reverse osmosis water.

2. The suspension concentrate containing mepiquat-calcium prohexadione according to claim 1, characterized in that: The weight ratio of the prohexadione calcium to mepiquat is (1.5-4):

1.

3. The suspension concentrate containing mepiquat-calcium prohexadione according to claim 2, characterized in that: The dispersant includes a cationic polycarboxylic acid dispersant and a polyarylphenol polyether modified dispersant.

4. The suspension concentrate containing mepiquat-calcium prohexadione according to claim 3, characterized in that: The weight ratio of the cationic polycarboxylic acid dispersant to the polyarylphenol polyether modified dispersant is (1-4):

1.

5. The suspension concentrate containing mepiquat-prohexadione-calcium according to claim 4, characterized in that: The weight ratio of the cationic polycarboxylic acid dispersant to the polyarylphenol polyether modified dispersant is (1-3):

1.

6. The suspension concentrate containing mepiquat-prohexadione-calcium according to claim 1 or 5, characterized in that: The synergist accounts for 1-3 wt % in the suspension concentrate of mepiquat-prohexadione-calcium.

7. The suspension concentrate containing mepiquat-prohexadione-calcium according to claim 6, characterized in that: The auxiliary agent includes a defoaming agent and / or a preservative.

8. A method for preparing a suspension concentrate containing mepiquat-prohexadione-calcium according to any one of claims 1 to 7, characterized in that: The following steps are involved: S1, adding prohexadione calcium, a dispersant, an antifreeze agent, a thickener, an additive and reverse osmosis water, dispersing them uniformly and then grinding them to obtain a mixture; S2, adding a synergist and mepiquat to the mixture, and continuing to grind to obtain.

9. The method for preparing the suspension containing mepiquat-prohexadione-calcium according to claim 8, characterized in that: The D90 particle size of the mixture is 0.2-4 microns.

10. Use of the suspension concentrate containing mepiquat-calcium prohexadione according to any one of claims 1 to 7, characterized in that: Used in cotton growth regulation.

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