Improved production device and process of voglibose dispersible tablets

Abstract

The invention discloses an improved production device and process of voglibose dispersible tablets. The device comprises a central control box, an extruder shell, a heating pipe, a speed reducer and a stirrer, the process comprises the following steps: 1, selecting and matching raw materials; 2, performing hot-melt extrusion on the raw materials; 3, crushing and filtering the raw materials; step 4, adding chemicals and stirring; step 5, tabletting and forming the medicines; and step 6, finished product detection and quality control. And step 7, packaging and selling finished products. According to the invention, a novel medicine treatment device is designed, raw materials are processed by adopting a hot-melt extruder, the voglibose with indissolvability is heated at high temperature in the device, and the voglibose and copovidone with a certain proportion are uniformly mixed, so that the indissolvability voglibose can be effectively and quickly melted and extruded, and the voglibose can be quickly melted and extruded; other special treatment is not needed, so that the addition of device components is reduced, the preparation cost of medicines is controlled, and the selling price of subsequent medicines is reasonably reduced.

Description

Technical Field

[0001] The invention relates to the technical field of voglibose dispersible tablets, in particular to an improved production device and process for voglibose dispersible tablets. Background Art

[0002] Voglibose dispersible tablets are indicated for improving postprandial hyperglycemia in diabetes. This product is suitable for patients who have not achieved significant results with diet therapy and exercise therapy, or who have not achieved significant results with oral hypoglycemic drugs or insulin preparations in addition to diet therapy and exercise therapy. The main ingredient of this product is voglibose, which is white or off-white tablets. When using, add this product to an appropriate amount of water, stir evenly and then take it. Voglibose dispersible tablets can effectively lower postprandial blood sugar levels and help diabetic patients control blood sugar. The drug can improve the body's ability to utilize insulin, help maintain normal blood sugar levels, and can help prevent the occurrence of diabetes-related complications by controlling blood sugar. Therefore, the production and process of voglibose dispersible tablets have become the direction of research.

[0003] However, the traditional production equipment and process of voglibose dispersible tablets cannot meet people's needs, and it has the following defects: First, no new drug processing equipment is designed. For voglibose dispersible tablets, the raw materials are poorly soluble drugs. The traditional method requires special treatments such as solubilization, dissolution promotion and taste masking, which cannot quickly process the raw materials. In addition, the production process is complicated and various components need to be added to meet the special treatment effect. The complex equipment makes it difficult to control the cost of drug preparation, resulting in high subsequent drug sales prices. In addition, the special treatment required in the drug preparation process increases the difficulty of operation, and the consumption of time and manpower cannot be controlled, which greatly increases the cost of drug preparation. The cost of drug preparation is increased; secondly, there is no drug crushing device. Before the drug is pressed into tablets, the raw materials need to be crushed to facilitate subsequent operations. Traditional raw material crushing is done manually, and the size of the raw materials cannot be controlled. Moreover, manual crushing consumes a lot of time and the efficiency cannot be improved, which increases the cost of drug preparation to a certain extent; thirdly, there is no drug mixing device. After the raw materials are crushed, the raw materials need to be mixed with various additives. Traditional drug mixing is done manually, and the dosage of the drug cannot be effectively controlled. Moreover, the effect of manual mixing cannot be guaranteed, which makes the quality of the finished drug uncontrollable and unable to meet customer needs. Summary of the invention

[0004] The object of the present invention is to provide an improved production device and process for voglibose dispersible tablets to solve the problems raised in the above background technology.

[0005] To achieve the above-mentioned purpose, the present invention provides the following technical solutions: an improved production device for voglibose dispersible tablets, comprising a central control box, a first motor is fixedly connected to the upper surface of the central control box, a first rotating shaft is fixedly connected to the output end of the first motor, a reducer is fixedly connected to the outer wall of one side of the first rotating shaft, an extrusion screw is fixedly connected to the other end of the first rotating shaft, an extruder housing is sleeved on the outer wall of one side of the extrusion screw, a heating layer is fixedly connected to the outer wall of one side of the extruder housing, a heating compartment is provided on the outer wall of one side of the heating layer, a heating pipe is fixedly connected to the outer wall of one side of the heating compartment, and the heating pipe is electrically connected to the central control box, a transfer tube is sleeved on the outer wall of one side of the extruder housing, one end of the extrusion screw is arranged in the transfer tube, one end of the transfer tube is fixedly connected to the first conveying pipe, the output end of the first conveying pipe is fixedly connected to the cutting machine housing, and a mixer housing is provided on the lower surface of the cutting machine housing.

[0006] As a further technical solution of the present invention, an input pipe is sleeved on the upper surface of the extruder housing, and the input pipe is sleeved on one side outer wall of the heating layer, a first flip sealing cover is provided on one side outer wall of the input pipe, a first electronic valve is fixedly connected to one side outer wall of the first flip sealing cover, and the first electronic valve is sleeved on one side outer wall of the input pipe, a heat insulation layer is fixedly connected to one side outer wall of the extruder housing, and the heat insulation layer is fixedly connected to the position of the heating layer corresponding to the heating pipe.

[0007] A second motor is fixedly connected to the upper surface of the cutting machine housing, a second rotating shaft is fixedly connected to the output end of the second motor, and the second rotating shaft is sleeved on one side outer wall of the cutting machine housing, a first roller is fixedly connected to one side outer wall of the second rotating shaft, a first cutting blade is fixedly connected to one side outer wall of the first roller, a driving wheel is fixedly connected to one side outer wall of the second rotating shaft, and the driving wheel is arranged on the upper surface of the first roller, and a conveyor belt is sleeved on one side outer wall of the driving wheel.

[0008] A driven wheel is sleeved on the outer wall of one side of the conveyor belt, a third rotating shaft is fixedly connected to the outer wall of one side of the driven wheel, and the third rotating shaft is fixedly connected to the cutting machine housing, a second roller is fixedly connected to the outer wall of one side of the third rotating shaft at a position corresponding to the first roller, a second cutting blade is fixedly connected to the outer wall of one side of the second roller, a mesh screen is fixedly connected to the outer wall of one side of the cutting machine housing, and the mesh screen is arranged on the lower surface of the second roller.

[0009] A second delivery pipe is fixedly connected to the upper surface of the mixer shell, and the other end of the second delivery pipe is fixedly connected to the lower surface of the cutting machine shell, a third motor is fixedly connected to the lower surface of the mixer shell, a protective shell is fixedly connected to one side outer wall of the third motor, an output end of the third motor is fixedly connected to a stirring drum, an agitator is fixedly connected to one side outer wall of the stirring drum, a solvent adding pipe is sleeved on one side outer wall of the mixer shell, a second flip sealing cover is provided on one side outer wall of the solvent adding pipe, a second electronic valve is fixedly connected to one side outer wall of the second flip sealing cover, and the second electronic valve is sleeved on one side outer wall of the solvent adding pipe, and an output pipe is sleeved on one side outer wall of the mixer shell.

[0010] A control console is fixedly connected to an outer wall of one side of the central control box, a bracket is fixedly connected to the lower surface of the central control box, and the cutter housing and the mixer housing are both fixedly connected to the bracket.

[0011] An improved production process for voglibose dispersible tablets, comprising step 1, raw material selection and preparation; step 2, raw material hot melt extrusion; step 3, raw material crushing and filtering; step 4, drug addition and stirring; step 5, drug tableting; step 6, finished product testing and quality control; step 7, finished product packaging and sales;

[0012] In the above step 1, a carrier material is selected and mixed with the raw material to reduce the activity of the raw material;

[0013] Wherein in the above step 2, the raw material is prepared by hot melt extrusion;

[0014] In the above step 3, the raw materials after heat capacity are cut and screened by a pulverizer;

[0015] In the above step 4, a proper amount of additives is added to the raw material powder, and the raw material powder is uniformly stirred by a mixer;

[0016] In the above step 5, the mixed drug is tableted to obtain a finished drug product;

[0017] In step 6 above, the finished drug product is tested and various quality controls are implemented to ensure stable and reliable quality;

[0018] In the above step seven, suitable packaging materials are selected to ensure the stability and safety of the drug during storage and transportation.

[0019] As a further technical solution of the present invention, in the step 2, the raw materials are prepared by hot melt extrusion, and the carrier material is selected as copolyvidone, which is mixed and stirred with voglibose having an active ingredient. After the stirring is completed, the mixed raw materials are input into the extruder housing through the input pipe, and the first flip sealing cover is controlled to rotate and open by the first electronic valve, so that the channel in the input pipe is open, and the first motor is started by controlling the control console to drive the first rotating shaft thereon to rotate, and the first rotating shaft drives the extrusion screw to rotate, and the inflowing raw materials move forward through the threaded channel on the extrusion screw. During the process, the control console controls the heating tube to start heating, and the heating tube is heated to 151°C and then maintained at a constant temperature. The raw materials on the extrusion screw are melted and extruded by heating, and the solubility and bioavailability of the dispersion after melting are improved.

[0020] As a further technical solution of the present invention, in the step three, the raw materials after heat capacity are cut and screened by a crusher, and the dispersion after melt extrusion is moved to the cutting machine housing through the transfer tube and the first conveying pipe, and the second motor is controlled by the control console to move, and the second motor drives the second rotating shaft to start rotating, and the driving wheel on the second rotating shaft drives the driven wheel to start rotating through the conveyor belt, and the driven wheel drives the third rotating shaft thereon to start rotating, so that the first cutting blade and the second cutting blade on the first roller and the second roller start to perform rotational cutting work, and the falling dispersion is crushed. The powder after cutting falls on the mesh screen, and the mesh screen adopts 60-120 mesh, so that the powder that meets the requirements enters the next process through the second conveying pipe.

[0021] As a further technical solution of the present invention, in the step four, an appropriate amount of additives is added to the raw material powder, and the powder is uniformly stirred by a mixer. After the dispersion is crushed, the dispersion enters the mixer housing through a second conveying pipe, and a suitable agent is added to the mixer through a solvent adding pipe. The filler is mannitol, the disintegrant is cross-linked polyvinylpyrrolidone, and the lubricant is magnesium stearate. The second flip sealing cover is opened by controlling the second electronic valve, and various solvents are added thereto. The third motor is controlled to rotate by the control console to drive the stirring drum thereon to rotate. The various reagents are uniformly stirred by the agitator on the stirring drum, and are transported to the tablet press through the output pipe.

[0022] Compared with the prior art, the present invention has the following beneficial effects: the present invention is designed with a novel drug processing device, which uses a hot melt extruder to process raw materials. For the poorly soluble voglibose, the device uses a high temperature for heating, and the voglibose is uniformly mixed with a certain proportion of copolyvidone, which can effectively make the poorly soluble voglibose quickly melt and extrude, without the need for other special treatments, reducing the addition of device components, and controlling the preparation cost of the drug to a certain extent, so that the subsequent drug selling price is reasonably reduced, and the simple preparation device makes the operation simpler, reduces the consumption of time and manpower, and improves the generation efficiency of the device; at the same time, a drug crushing device is designed, which uses a motor, a roller and a cutting blade to realize the molten drug The material can be evenly crushed without manual operation, which reduces the use of manpower. The crushed raw materials are screened with a mesh sieve, so that the size of the crushed raw materials is controlled, the time required for crushing is reduced, the operation efficiency of the device is improved, and the preparation cost of the drug is reduced to a certain extent. A drug mixing device is also designed, which uses a motor with a stirrer to complete the uniform mixing of the drug. After the raw materials are crushed, a certain amount of filler, disintegrant and lubricant are added to the raw materials. There is no need for manual operation, the amount of drug added can be effectively controlled, and the mixing effect of the drug is guaranteed, so that the quality of the finished drug is reasonably controlled, the consumption of manpower and time is reduced, and the preparation cost of the drug is reduced to a certain extent. BRIEF DESCRIPTION OF THE DRAWINGS

[0023] Figure 1 It is a schematic diagram of the three-dimensional structure of the present invention;

[0024] Figure 2 It is a front view structural schematic diagram of the present invention;

[0025] Figure 3 It is a schematic diagram of the top view of the structure of the present invention;

[0026] Figure 4 It is a side view structural schematic diagram of the present invention;

[0027] Figure 5 It is a schematic diagram of the three-dimensional cutaway structure of the present invention;

[0028] Figure 6 It is a three-dimensional structural schematic diagram of the cutting machine of the present invention;

[0029] Figure 7 The present invention is a flow chart of the method.

[0030] In the figure: 1, bracket; 2, control console; 3, central control box; 4, first motor; 5, input pipe; 6, first electronic valve; 7, extruder housing; 8, adapter pipe; 9, first conveying pipe; 10, second motor; 11, cutting machine housing; 12, first flip sealing cover; 13, heating layer; 14, heating tube; 15, insulation layer; 16, extrusion screw; 17, heating compartment; 18, first roller; 19, mesh screen; 20, second electronic valve; 21, Solvent adding pipeline; 22, mixer housing; 23, protective shell; 24, third motor; 25, stirring drum; 26, output pipeline; 27, stirrer; 28, second conveying pipe; 29, reducer; 30, first rotating shaft; 31, second rotating shaft; 32, driving wheel; 33, conveyor belt; 34, third rotating shaft; 35, driven wheel; 36, second drum; 37, first cutting blade; 38, second cutting blade; 39, second flip sealing cover. DETAILED DESCRIPTION

[0031] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0032] Please refer to the attached Figure 1 -Attached Figure 6An embodiment of the present invention is as follows: an improved production device for voglibose dispersible tablets, comprising a central control box 3, a first motor 4 is fixedly connected to the upper surface of the central control box 3, a first rotating shaft 30 is fixedly connected to the output end of the first motor 4, a reducer 29 is fixedly connected to the outer wall of one side of the first rotating shaft 30, an extrusion screw 16 is fixedly connected to the other end of the first rotating shaft 30, an extruder housing 7 is sleeved on the outer wall of one side of the extrusion screw 16, a heating layer 13 is fixedly connected to the outer wall of one side of the extruder housing 7, a heating compartment 17 is provided on the outer wall of one side of the heating layer 13, a heating pipe 14 is fixedly connected to the outer wall of one side of the heating compartment 17, and the heating pipe 14 is electrically connected to the central control box 3, the extruder housing 7 A transfer tube 8 is sleeved on one side outer wall of the extruder housing 7, and one end of the extrusion screw 16 is arranged in the transfer tube 8, one end of the transfer tube 8 is fixedly connected to the first delivery tube 9, the output end of the first delivery tube 9 is fixedly connected to the cutting machine housing 11, and the lower surface of the cutting machine housing 11 is provided with a mixer housing 22; an input tube 5 is sleeved on the upper surface of the extruder housing 7, and the input tube 5 is sleeved on one side outer wall of the heating layer 13, a first flip sealing cover 12 is provided on one side outer wall of the input tube 5, a first electronic valve 6 is fixedly connected on one side outer wall of the first flip sealing cover 12, and the first electronic valve 6 is sleeved on one side outer wall of the input tube 5, a heat insulation layer 15 is fixedly connected to one side outer wall of the extruder housing 7, and the heat insulation layer 15 is fixedly connected. Connected to the position of the heating tube 14 on the heating layer 13, the first electronic valve 6 is used to monitor the principle flow rate in the input tube 5, and reasonably adjust the first flip sealing cover 12 under appropriate conditions; the upper surface of the cutting machine housing 11 is fixedly connected to the second motor 10, the output end of the second motor 10 is fixedly connected to the second rotating shaft 31, and the second rotating shaft 31 is sleeved on one side of the outer wall of the cutting machine housing 11, the first roller 18 is fixedly connected to the outer wall of one side of the second rotating shaft 31, the first cutting blade 37 is fixedly connected to the outer wall of one side of the first roller 18, and the driving wheel 32 is fixedly connected to the outer wall of one side of the second rotating shaft 31, and the driving wheel 32 is arranged on the upper surface of the first roller 18, and the driving wheel 32 A conveyor belt 33 is sleeved on one side of the outer wall, and the conveyor belt 33 is used to connect the driving wheel 32 and the driven wheel 35; a driven wheel 35 is sleeved on one side of the outer wall of the conveyor belt 33, and a third rotating shaft 34 is fixedly connected to one side of the outer wall of the driven wheel 35, and the third rotating shaft 34 is fixedly connected to the cutting machine housing 11, and a second roller 36 is fixedly connected to the position of the first roller 18 on one side of the outer wall of the third rotating shaft 34, and a second cutting blade 38 is fixedly connected to one side of the outer wall of the second roller 36. A mesh screen 19 is fixedly connected to one side of the outer wall of the cutting machine housing 11, and the mesh screen 19 is arranged on the lower surface of the second roller 36. The mesh screen 19 is used to filter the crushed raw materials to ensure that the size of the raw materials after crushing meets the required size;The upper surface of the mixer housing 22 is fixedly connected with a second delivery pipe 28, and the other end of the second delivery pipe 28 is fixedly connected to the lower surface of the cutting machine housing 11, the lower surface of the mixer housing 22 is fixedly connected with a third motor 24, one side of the outer wall of the third motor 24 is fixedly connected with a protective shell 23, the output end of the third motor 24 is fixedly connected with a stirring drum 25, one side of the outer wall of the stirring drum 25 is fixedly connected with a stirrer 27, one side of the outer wall of the mixer housing 22 is sleeved with a solvent adding pipeline 21, one side of the outer wall of the solvent adding pipeline 21 is provided with a second flip sealing cover 39, the second flip sealing cover 39 is fixedly connected with the second flip sealing cover 39, and the second flip sealing cover 39 is fixedly connected with the second flip sealing cover 39. A second electronic valve 20 is fixedly connected to one side outer wall of the cover 39, and the second electronic valve 20 is sleeved on one side outer wall of the solvent adding pipeline 21. An output pipeline 26 is sleeved on one side outer wall of the mixer housing 22. The second electronic valve 20 is used to detect the inflow of solution in the solvent adding pipeline 21 to ensure that the amount of solvent flowing in meets the specified standard; a control console 2 is fixedly connected to one side outer wall of the central control box 3, and a bracket 1 is fixedly connected to the lower surface of the central control box 3, and the cutting machine housing 11 and the mixer housing 22 are fixedly connected to the bracket 1. The bracket 1 is used to support the device to improve the overall structural strength of the device. ;

[0033] See also Figure 7 The present invention provides an embodiment: an improved production process for voglibose dispersible tablets, comprising step 1, raw material selection and matching; step 2, raw material hot melt extrusion; step 3, raw material crushing and filtering; step 4, drug addition and stirring; step 5, drug tableting; step 6, finished product testing and quality control; step 7, finished product packaging and sales;

[0034] In the above step 1, a carrier material is selected to be mixed with the raw material to reduce the activity of the raw material, and the carrier material is selected from copovidone, which is mixed and stirred with voglibose having an active ingredient;

[0035] In the above step 2, the raw materials are prepared by hot melt extrusion, and after stirring, the mixed raw materials are input into the extruder housing 7 through the input pipe 5, and the first flip sealing cover 12 is controlled to rotate and open by the first electronic valve 6, so that the channel in the input pipe 5 is open, and the first motor 4 is controlled to start by the control console 2 to drive the first rotating shaft 30 thereon to rotate, and the first rotating shaft 30 drives the extrusion screw 16 to rotate, and the inflowing raw materials move forward through the threaded channel on the extrusion screw 16. During the process, the control console 2 controls the heating tube 14 to start heating, and the heating tube 14 is heated to 151°C and then kept at a constant temperature. The raw materials on the extrusion screw 16 are melted and extruded by heating, and the solubility and bioavailability of the dispersion after melting are improved;

[0036] In the above step three, the raw material after heat capacity is cut and screened by a pulverizer, and the dispersion after melt extrusion is moved to the cutting machine housing 11 through the transfer tube 8 and the first conveying tube 9, and the second motor 10 is controlled by the console 2 to move, and the second motor 10 drives the second rotating shaft 31 to start rotating, and the driving wheel 32 on the second rotating shaft 31 drives the driven wheel 35 to start rotating through the conveyor belt 33, and the driven wheel 35 drives the third rotating shaft 34 thereon to start rotating, so that the first cutting blade 37 and the second cutting blade 38 on the first roller 18 and the second roller 36 start to perform rotational cutting work, and the falling dispersion is crushed. The powder after cutting falls on the mesh screen 19, and the mesh screen 19 adopts 60-120 meshes, so that the powder that meets the requirements enters the next process through the second conveying tube 28;

[0037] In the above step 4, a proper amount of additives is added to the raw material powder, and the raw material powder is uniformly stirred by a mixer. After the dispersion is crushed, the dispersion enters the mixer housing 22 through the second conveying pipe 28, and a suitable agent is added to the mixer through the solvent adding pipe 21. The filler is mannitol, the disintegrant is cross-linked polyvinylpyrrolidone, and the lubricant is magnesium stearate. The second electronic valve 20 controls the second flip sealing cover 39 to open, and various solvents are added thereto. The control console 2 controls the third motor 24 to rotate, driving the stirring drum 25 thereon to rotate, and the agitator 27 on the stirring drum 25 completes the uniform stirring of various reagents, and the agitator 27 is used to transport the agitators to the tablet press through the output pipe 26.

[0038] In the above step 5, the mixed drugs are tableted to obtain a finished drug product, and the mixed reagents are tableted using an automatic tablet press, and the tablet hardness is controlled to be 28-36N to obtain a finished drug product;

[0039] In the above step six, the finished drug product is tested and various quality controls are implemented to ensure stable and reliable quality. After the drug is formed, the content uniformity test can be used to ensure that the drug content in each tablet is uniform, the dissolution test can be used to ensure whether the drug is dissolved within the specified time, and the content of the drug components can be determined by content determination to ensure that the drug meets the specified requirements, and stability measurement can be performed to ensure that the quality of the drug is guaranteed within the validity period;

[0040] In the above step seven, suitable packaging materials are selected to ensure the stability and safety of the drug during storage and transportation. The packaging is aluminum-plastic blister packaging, and the number of tablets can be changed according to actual conditions.

[0041] Based on the above, the advantages of the present invention are: when using the present invention, firstly, the carrier material is selected, and copovidone and voglibose having an active ingredient are mixed and stirred. After the stirring is completed, the mixed raw materials are input into the extruder housing 7 through the input pipe 5, and the first electronic valve 6 is used to control the first flip sealing cover 12 to rotate and open, so that the channel in the input pipe 5 is open. During the raw material transportation process, the first electronic valve 6 can be used to monitor the principle flow rate in the input pipe 5, and the first flip sealing cover 12 is reasonably adjusted under appropriate conditions. The power supply in the central control box 3 is controlled by the console 2 to start, so that the first motor 4 starts to start, driving the first rotating shaft 30 thereon to rotate, and the first rotating shaft 30 drives the extrusion screw 16 to rotate, and the raw materials flowing in The heating tube 14 moves forward through the threaded channel on the extrusion screw 16. During the process, the central control box 3 controls the heating tube 14 to start heating. The heating tube 14 is heated to 151°C and then maintained at a constant temperature. The raw materials on the extrusion screw 16 are melted and extruded by heating. The solubility and bioavailability of the dispersion after melting are improved. The heating tube 14 is installed through the heating layer 13 and the heating compartment 17. The insulation layer 15 is used to isolate the heating layer 13 from the extruder housing 7 to avoid damage to the equipment caused by excessive temperature and burns to the operator. The reducer 29 is used to control the speed of the first motor 4. The dispersion after melt extrusion is moved to the cutting machine housing 11 through the transfer tube 8 and the first conveying tube 9. The second motor 10 is controlled by the control console 2 to move. The second motor 10 drives the second rotating shaft 31 to start rotating, and the driving wheel 32 on the second rotating shaft 31 drives the driven wheel 35 to start rotating through the conveyor belt 33, and the driven wheel 35 drives the third rotating shaft 34 thereon to start rotating, so that the first cutting blade 37 and the second cutting blade 38 on the first roller 18 and the second roller 36 start to perform a rotary cutting operation, and the falling dispersion is crushed. After the cutting is completed, the powder falls on the mesh screen 19, and the mesh screen 19 adopts a 60-120 mesh, so that the powder that meets the requirements enters the next process through the second conveying pipe 28. After the dispersion is crushed, the dispersion enters the mixer housing 22 through the second conveying pipe 28, and a suitable agent is added to the mixer through the solvent adding pipe 21. The filler is selected from glycerol. Dew alcohol, cross-linked polyvinylpyrrolidone is selected as the disintegrant, and magnesium stearate is selected as the lubricant. The second flip sealing cover 39 is opened by the second electronic valve 20 to control various solvents to be added thereto. The second electronic valve 20 is used to detect the inflow of the solution in the solvent adding pipeline 21 to ensure that the amount of the inflowing solvent meets the prescribed standard. The third motor 24 is controlled to rotate by the control console 2 to drive the stirring roller 25 thereon to rotate. The stirrer 27 on the stirring roller 25 is used to complete the uniform stirring of various reagents, and the reagents are transported to the tablet press through the output pipeline 26. The mixed reagents are tableted by an automatic tablet press, and the tablet hardness is controlled to be 28-36N to obtain a finished drug product. After the drug is formed, the uniform content of the drug in each tablet can be ensured by content uniformity detection.Dissolution testing can be used to ensure whether the drug is dissolved within the specified time. The content of the drug's components can be determined by content determination to ensure that the drug meets the specified requirements, and stability measurement can be performed to ensure that the quality of the drug is guaranteed within the validity period. After completing various tests, appropriate packaging materials must be selected to ensure the stability and safety of the drug during storage and transportation. The packaging is aluminum-plastic blister packaging, and the number of tablets can be changed according to actual conditions; the bracket 1 is used to support the device to improve the overall structural strength of the device, and the protective shell 23 is used to protect the third motor 24 to prevent the third motor 24 from being affected by the environment.

[0042] It will be apparent to those skilled in the art that the invention is not limited to the details of the exemplary embodiments described above and that the invention can be implemented in other specific forms without departing from the spirit or essential features of the invention. Therefore, the embodiments should be considered exemplary and non-limiting in all respects, and the scope of the invention is defined by the appended claims rather than the foregoing description, and it is intended that all variations falling within the meaning and scope of the equivalent elements of the claims be included in the invention. Any reference numeral in a claim should not be considered as limiting the claim to which it relates.

Claims

1. An improved production device for voglibose dispersible tablets, comprising a central control box (3), characterized in that: The upper surface of the central control box (3) is fixedly connected to a first motor (4), the output end of the first motor (4) is fixedly connected to a first rotating shaft (30), a reducer (29) is fixedly connected to an outer wall of one side of the first rotating shaft (30), the other end of the first rotating shaft (30) is fixedly connected to an extrusion screw (16), an extruder housing (7) is sleeved on an outer wall of one side of the extrusion screw (16), a heating layer (13) is fixedly connected to an outer wall of one side of the extruder housing (7), and a heating compartment is provided on an outer wall of one side of the heating layer (13). (17), a heating tube (14) is fixedly connected to an outer wall of one side of the heating compartment (17), and the heating tube (14) is electrically connected to the central control box (3), a transfer tube (8) is sleeved on an outer wall of one side of the extruder housing (7), and one end of the extrusion screw (16) is arranged in the transfer tube (8), one end of the transfer tube (8) is fixedly connected to a first conveying tube (9), and the output end of the first conveying tube (9) is fixedly connected to a cutting machine housing (11), and a mixer housing (22) is arranged on the lower surface of the cutting machine housing (11).

2. The improved production device for voglibose dispersible tablets according to claim 1, characterized in that: An input pipe (5) is sleeved on the upper surface of the extruder housing (7), and the input pipe (5) is sleeved on one side outer wall of the heating layer (13); a first flip sealing cover (12) is provided on one side outer wall of the input pipe (5); a first electronic valve (6) is fixedly connected to one side outer wall of the first flip sealing cover (12), and the first electronic valve (6) is sleeved on one side outer wall of the input pipe (5); a heat insulation layer (15) is fixedly connected to one side outer wall of the extruder housing (7), and the heat insulation layer (15) is fixedly connected to a position on the heating layer (13) corresponding to the heating pipe (14).

3. The improved production device for voglibose dispersible tablets according to claim 1, characterized in that: A second motor (10) is fixedly connected to the upper surface of the cutting machine housing (11); a second rotating shaft (31) is fixedly connected to the output end of the second motor (10); and the second rotating shaft (31) is sleeved on one side outer wall of the cutting machine housing (11); a first roller (18) is fixedly connected to one side outer wall of the second rotating shaft (31); a first cutting blade (37) is fixedly connected to one side outer wall of the first roller (18); a driving wheel (32) is fixedly connected to one side outer wall of the second rotating shaft (31); the driving wheel (32) is arranged on the upper surface of the first roller (18); and a conveyor belt (33) is sleeved on one side outer wall of the driving wheel (32).

4. The improved production device for voglibose dispersible tablets according to claim 3, characterized in that: A driven wheel (35) is sleeved on one side outer wall of the conveyor belt (33); a third rotating shaft (34) is fixedly connected to one side outer wall of the driven wheel (35); and the third rotating shaft (34) is fixedly connected to the cutting machine housing (11); a second roller (36) is fixedly connected to one side outer wall of the third rotating shaft (34) at a position corresponding to the first roller (18); a second cutting blade (38) is fixedly connected to one side outer wall of the second roller (36); and a mesh screen (19) is fixedly connected to one side outer wall of the cutting machine housing (11); and the mesh screen (19) is arranged on the lower surface of the second roller (36).

5. The improved production device for voglibose dispersible tablets according to claim 1, characterized in that: The upper surface of the mixer housing (22) is fixedly connected to a second conveying pipe (28), and the other end of the second conveying pipe (28) is fixedly connected to the lower surface of the cutting machine housing (11); the lower surface of the mixer housing (22) is fixedly connected to a third motor (24); a protective shell (23) is fixedly connected to an outer wall on one side of the third motor (24); an output end of the third motor (24) is fixedly connected to a stirring drum (25); an agitator (27) is fixedly connected to an outer wall on one side of the stirring drum (25); a solvent adding pipe (21) is sleeved on an outer wall on one side of the mixer housing (22); a second flip sealing cover (39) is provided on an outer wall on one side of the solvent adding pipe (21); a second electronic valve (20) is fixedly connected to an outer wall on one side of the second flip sealing cover (39); and the second electronic valve (20) is sleeved on an outer wall on one side of the solvent adding pipe (21); and an output pipe (26) is sleeved on an outer wall on one side of the mixer housing (22).

6. The improved production device for voglibose dispersible tablets according to claim 1, characterized in that: A control console (2) is fixedly connected to one side outer wall of the central control box (3), a bracket (1) is fixedly connected to the lower surface of the central control box (3), and the cutting machine housing (11) and the mixer housing (22) are both fixedly connected to the bracket (1).

7. An improved production process for voglibose dispersible tablets, comprising step 1, raw material selection and preparation; step 2, raw material hot melt extrusion; step 3, raw material crushing and filtering; step 4, drug addition and stirring; step 5, drug tableting; step 6, finished product testing and quality control; step 7, finished product packaging and sale; characterized in that: In the above step 1, a carrier material is selected and mixed with the raw material to reduce the activity of the raw material; Wherein in the above step 2, the raw material is prepared by hot melt extrusion; In the above step 3, the raw materials after heat capacity are cut and screened by a pulverizer; In the above step 4, a proper amount of additives is added to the raw material powder, and the raw material powder is uniformly stirred by a mixer; In the above step 5, the mixed drug is tableted to obtain a finished drug product; In step 6 above, the finished drug product is tested and various quality controls are implemented to ensure stable and reliable quality; In the above step seven, suitable packaging materials are selected to ensure the stability and safety of the drug during storage and transportation.

8. The improved production process of voglibose dispersible tablets according to claim 7, characterized in that: In the second step, the raw materials are prepared by hot melt extrusion, the carrier material is selected as copolyvidone, and the raw materials are mixed and stirred with voglibose having an active ingredient. After the stirring is completed, the mixed raw materials are input into the extruder housing (7) through the input pipe (5), and the first flip sealing cover (12) is controlled to rotate and open through the first electronic valve (6), so that the channel in the input pipe (5) is opened, and the control console (2) controls the first motor (4) to start, driving the first rotating shaft (30) thereon to rotate, and the first rotating shaft (30) drives the extrusion screw (16) to rotate, and the raw materials flowing in move forward through the threaded channel on the extrusion screw (16). During the process, the control console (2) controls the heating tube (14) to start heating, and the heating tube (14) is heated to 151° C. and then kept at a constant temperature. The raw materials on the extrusion screw (16) are melted and extruded by heating, and the dissolution rate and bioavailability of the dispersion after melting are improved.

9. The improved production process of voglibose dispersible tablets according to claim 7, characterized in that: In the step three, the raw material after heat capacity is cut and screened by a pulverizer, and the dispersion after melt extrusion is moved into the cutting machine housing (11) through the transfer tube (8) and the first conveying tube (9), and the second motor (10) is controlled by the control console (2) to move, and the second motor (10) drives the second rotating shaft (31) to start rotating, and the driving wheel (32) on the second rotating shaft (31) drives the driven wheel (35) to start rotating through the conveyor belt (33), and the driven wheel (35) drives the third rotating shaft (34) thereon to start rotating, so that the first cutting blade (37) and the second cutting blade (38) on the first roller (18) and the second roller (36) start to perform a rotational cutting operation, and the falling dispersion is pulverized. After the cutting is completed, the powder falls on the mesh screen (19), and the mesh screen (19) adopts 60-120 meshes, so that the powder that meets the requirements enters the next process through the second conveying tube (28).

10. The improved production process of voglibose dispersible tablets according to claim 7, characterized in that: In the step 4, a proper amount of additives is added to the raw material powder, and the powder is uniformly stirred by a stirrer. After the dispersion is crushed, the dispersion enters the stirrer housing (22) through the second conveying pipe (28), and a suitable agent is added to the stirrer through the solvent adding pipe (21). The filler is selected as mannitol, the disintegrant is selected as cross-linked polyvinylpyrrolidone, and the lubricant is selected as magnesium stearate. The second flip sealing cover (39) is opened by controlling the second electronic valve (20), and various solvents are added thereto. The control console (2) controls the third motor (24) to rotate, thereby driving the stirring roller (25) thereon to rotate. The stirrer (27) on the stirring roller (25) is used to evenly stir various reagents, and the reagents are then transported to the tablet press through the output pipe (26).

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