Throat-clearing lozenge candy and preparation method thereof

Abstract

The invention discloses a throat-clearing lozenge candy and a preparation method thereof, and belongs to the technical field of pharmaceutical preparations, the throat-clearing lozenge candy comprises the following raw material components by weight: 10-15 parts of a Mongolian medicine hosta plantaginea water extract; 2-5 parts of pear powder; 5 to 15 parts of raisin; 5-15 parts of rock sugar; 5 to 15 parts of honey; and 0.6 to 1.5 parts of a preservative. According to the lozenge sugar, the Mongolian medicine hosta plantaginea flower water extract serves as a main active ingredient, the Mongolian medicine hosta plantaginea flower serves as a traditional Chinese medicinal material, and the water extract is widely considered to have the remarkable effects of clearing away heat and toxic materials, diminishing inflammation, relieving pain and clearing heat from throat, so that the lozenge sugar has potential advantages in the aspect of treating throat diseases such as chronic pharyngitis. Meanwhile, due to the addition of the pear powder, the natural fruity flavor of the lozenge sugar is increased, additional nutritional value is added to the lozenge sugar due to the rich vitamins and minerals, and throat health maintenance is facilitated.

Description

Technical Field

[0001] The invention relates to the technical field of pharmaceutical preparations, in particular to a throat-clearing and throat-relieving lozenge and a preparation method thereof. Background Art

[0002] Chronic pharyngitis is a chronic inflammation of the upper respiratory tract of the pharyngeal mucosa, submucosal and lymphoid tissues, often manifested as upper respiratory tract infection symptoms such as redness, swelling and pain in the throat, foreign body sensation, itchy throat, irritating cough, etc., with high incidence, stubborn symptoms, lingering and difficult to cure, easy to relapse and other characteristics, seriously affecting the quality of life of patients. According to statistics, nearly 1 / 3 of the patients who visit the otolaryngology clinic on a daily basis are chronic pharyngitis patients. Clinically, anti-infection, acid-reducing, anti-allergic and other treatments are often used to improve symptoms, but they are often unable to be cured and require repeated medication. In recent years, with the continuous influence of various factors in people's living environment, especially those who stay up late, drink alcohol and smoke, the incidence rate is as high as more than 60%, and it is showing a sharp upward trend. It can be seen that pharyngitis has caused serious harm to human health.

[0003] Mongolian medicine believes that chronic pharyngitis belongs to the category of "throat disease". In daily diet, excessive consumption of spicy or irritating food, smoking, alcoholism, fatigue, excessive talk, pollution of living environment, long-term stimulation to the throat, or inappropriate diet and living in cold seasons, so that bacteria enter the throat and affect Qisu, Xila, Bada Gan heat and stickiness. The throat is the ascending Heyi serial road, and the pharynx is rich in blood vessels and lymph. When the three roots are out of balance, Qisu, Xila, Bada Gan are disordered, and stickiness is combined to cause this disease.

[0004] The dosage forms for treating chronic pharyngitis include decoctions, pills, lozenges, granules, aerosols, etc. Each dosage form has its specific application scenarios and limitations. Although decoctions have significant efficacy and can be flexibly adjusted according to the patient's symptoms, their preparation and taking processes are cumbersome and not suitable for a fast-paced lifestyle. Although granules and pills have advantages in portability, granules still need to be brewed when taken, which is not convenient enough, and pills usually take effect slowly, which may not be suitable for patients who need to quickly relieve symptoms. To this end, a throat-clearing lozenge and a preparation method thereof are proposed.

[0005] The above information disclosed in this background technology is only used to increase the understanding of the background technology of the present invention and therefore, it may include information that does not constitute the prior art known to a person of ordinary skill in the art. Summary of the invention

[0006] The present invention aims to solve at least one of the technical problems existing in the prior art that each dosage form has its specific application scenario and limitations. To this end, one object of the present invention is to provide a throat clearing lozenge and a preparation method thereof.

[0007] To achieve the above object, the present invention provides the following technical solutions:

[0008] A throat-clearing lozenge comprises the following raw material components in parts by weight: 10-15 parts of Mongolian medicine Hosta flower water extract; 2-5 parts of pear powder; 5-15 parts of raisins; 5-15 parts of crystal sugar; 5-15 parts of honey; and 0.6-1.5 parts of preservatives.

[0009] Hosta plantaginea is the dried flower of Hosta plant of Liliaceae. Its Mongolian name is Has-Hatagul-Qiqige, Chaganbangzhan, Chagangarbu, etc. It is a common medicine used in Mongolian medicine to treat pharyngitis. It has the effects of clearing heat, detoxifying, relieving cough and benefiting throat. It is mainly used to treat sore throat, hoarseness, lung heat and antipyretic. The three types of Mongolian medicine compound preparations based on Hosta plantaginea are Hosta Qingyan Fifteen Flavor Pills, Hosta Qingyan Fifteen Flavor Powder and Qingyan Six Flavor Powder, which are used to treat sore throat, asthma, hoarseness and other diseases. The book "Recognizing Medicine White Crystal" written by Mongolian doctor Yixibalajul recorded: "Hosta grows in wetlands, and the white ones are the best, bitter, treat throat diseases, detoxify and clear epidemic heat". The book "Infallible Mongolian Medicine" written by the Mongolian medicine saint Zhanbula Dorji in the 19th century recorded: "Hosta is cool in nature, clears lung heat, treats throat diseases and detoxifies". Menghe Deliger, "Chinese Materia Medica" (Mongolian Medicine Volume) records that it is cold in nature, astringent and bitter in taste, soft, tender and thin in effect, and has the effects of clearing heat, detoxifying, relieving cough and benefiting the throat. It is mainly used to treat sore throat, hoarseness, lung heat and toxic heat. The Mongolian medicine prescription Bangzhan-15 uses the Mongolian medicine for throat relief, Hosta flower as the main medicine, which has the effects of reducing swelling, relieving cough and relieving asthma. It is mainly used to treat sore throat, asthma, chest tightness, lung heat cough caused by colds, etc. Bangzhan-10 also uses the Mongolian medicine for throat relief, Hosta flower as the main medicine, which has the effects of clearing heat and reducing swelling. It is mainly used to treat throat paralysis, hoarseness, sore throat caused by Bada dry heat.

[0010] Pear powder is a powdered food additive or ingredient made from pears through drying and grinding. Pear powder contains vitamins, minerals, dietary fiber and a variety of antioxidants.

[0011] Rock sugar, also known as rock sugar or lump sugar, is made by heating a sucrose solution to a saturated state and then cooling it to crystallize. Rock sugar is considered to have certain medicinal value in traditional Chinese medicine, and has the effects of moistening the lungs and relieving coughs, harmonizing the middle and benefiting the lungs, replenishing energy, clearing away heat and detoxifying, and improving taste.

[0012] Raisins are a type of dried fruit that is made by drying grapes naturally or using artificial drying methods to remove most of the water. Raisins are rich in sugars, vitamins (such as B vitamins), minerals (such as iron, potassium, copper and magnesium), antioxidants (such as flavonoids) and dietary fiber.

[0013] Honey has the effect of moistening the lungs and is often used to treat dry coughs and coughs with little phlegm. It can relieve sore throats and cough symptoms. It also has the effects of promoting digestion, antibacterial and anti-inflammatory, anti-oxidation, enhancing immunity, promoting wound healing, relieving fatigue, calming the nerves, and beautifying the skin.

[0014] As a further optimization scheme of the present invention, the Mongolian medicine Hosta flos water extract is a total polysaccharide.

[0015] As a further optimization scheme of the present invention, the preservative is one or more of sodium benzoate and citric acid.

[0016] A method for preparing a throat-clearing lozenge comprises the following steps:

[0017] Step 1: prepare and pretreat pear powder, total polysaccharides, raisins and crystal sugar;

[0018] Step 2: Mix the prepared raw materials and emulsify the mixture using a high-speed shear emulsifier;

[0019] Step 3: placing the emulsified mixture in a vacuum drying oven to slowly dry and remove moisture;

[0020] Step 4: Crush the dried material, pass it through an 80-mesh sieve to obtain powder, mix the powder with magnesium stearate, and finally, use a tablet press to press it into lozenges.

[0021] As a further optimization scheme of the present invention, the specific steps of extracting total polysaccharides from Hosta flowers by water extraction are:

[0022] The dried Mongolian medicine hosta flower is selected as a raw material, the dried hosta flower is crushed into powder, the crushed hosta flower is put into distilled water for 6-8 hours to soften the plant cell wall so that the polysaccharide is dissolved, the soaked hosta flower and the water are heated to boiling, the cooking time is 1-2 hours, and the extraction process is repeated 2-3 times, and new distilled water is used each time;

[0023] The extracted mixed solution was cooled to room temperature, and the cooled extract was centrifuged at a speed of 4000-6000 rpm for 10-20 min to remove insoluble impurities to obtain a supernatant;

[0024] The supernatant after centrifugation is concentrated by a vacuum concentration device to remove most of the water to obtain a polysaccharide concentrate, the concentrate is preliminarily purified by a DEAE-cellulose ion exchange column, the preliminarily purified polysaccharide solution is further purified by gel filtration chromatography to separate polysaccharides with different molecular weights to obtain polysaccharide components, the collected polysaccharide solution is dialyzed using a dialysis bag, and the dialyzed polysaccharide solution is freeze-dried to obtain a dry polysaccharide powder.

[0025] As a further optimization scheme of the present invention, in step 2, the mixing time of the raw materials is 10-20 minutes, the rotation speed of the emulsifier is 1000-10000 rpm, and the emulsification time is 3-10 minutes.

[0026] As a further optimization scheme of the present invention, in step three, the temperature of the drying oven is set at 40-60° C., and the drying is stopped when the water content of the mixture is lower than 5%.

[0027] Compared with the prior art, the present invention has the following beneficial effects:

[0028] The lozenges of the present invention use the Mongolian medicine hosta flower water extract as a main active ingredient. As a traditional Chinese medicinal material, the Mongolian medicine hosta flower, its water extract is widely believed to have the significant effects of clearing away heat and detoxifying, relieving inflammation and pain, and clearing the throat, which makes it have potential advantages in treating throat diseases such as chronic pharyngitis. At the same time, the addition of pear powder not only increases the natural fruity aroma of the lozenges, but also adds additional nutritional value to the lozenges due to its rich vitamins and minerals, which helps to maintain throat health. Raisins further enhance the taste and health care function of the product. The combination of rock sugar and honey provides the lozenges with mild sweetness. At the same time, the throat-moistening property of honey and the throat-clearing effect of hosta can work together to relieve throat discomfort.

[0029] The above summary is for illustrative purposes only and is not intended to be limiting in any way. In addition to the illustrative aspects, embodiments and features described above, further aspects, embodiments and features of the present invention will be readily apparent by reference to the accompanying drawings and the following detailed description. BRIEF DESCRIPTION OF THE DRAWINGS

[0030] Figure 1 The present invention is a flow chart of the method for preparing the lozenge. DETAILED DESCRIPTION

[0031] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0032] The present invention provides a technical solution:

[0033] Embodiment 1

[0034] A throat-clearing lozenge comprises the following raw material components in parts by weight: 10 parts of Mongolian medicine Hosta flower water extract; 2 parts of pear powder; 5 parts of raisins; 5 parts of crystal sugar; 5 parts of honey; and 0.6 parts of preservatives.

[0035] The Mongolian medicine Hosta flower water extract is total polysaccharide. The preservative is one or more of sodium benzoate and citric acid.

[0036] Embodiment 2

[0037] A throat-clearing lozenge comprises the following raw material components in parts by weight: 15 parts of Mongolian medicine Hosta flower water extract; 5 parts of pear powder; 15 parts of raisins; 15 parts of crystal sugar; 15 parts of honey; and 1.5 parts of preservatives.

[0038] Embodiment 3

[0039] A throat-clearing lozenge comprises the following raw material components in parts by weight: 13 parts of Mongolian medicine Hosta flower water extract; 4 parts of pear powder; 11 parts of raisins; 10 parts of crystal sugar; 11 parts of honey; and 1 part of preservative.

[0040] Embodiment 4

[0041] See also Figure 1 , a method for preparing a throat-clearing lozenge comprises the following steps:

[0042] Step 1: prepare and pretreat pear powder, total polysaccharides, raisins and crystal sugar;

[0043] Steps for freeze drying pear powder:

[0044] Wash the surface of the pear with clean water, remove the core and stalk of the pear, cut into pieces and peel, freeze the processed pear pieces in a freezer below -40°C to reduce the formation of ice crystals, put the frozen pear pieces into a freeze dryer to remove moisture by sublimation, the freeze drying time is 12-48 hours, use a grinder to grind the dried pear pieces into powder, and filter with a 100-mesh sieve to obtain uniform pear powder.

[0045] Steps for processing raisins:

[0046] Wash the raisins, soak them in warm water for 30-60 minutes to soften them, use a dicer to cut the raisins into small pieces, use a centrifuge to drain the cut raisins, and finally, use hot air drying to remove excess moisture. The drying temperature is 40-60℃, the drying time is 6-12h, and the moisture content should be reduced to 15-20%.

[0047] Dissolving rock sugar: Crush the rock sugar and dissolve it in an appropriate amount of hot water to make a rock sugar solution.

[0048] Specific steps for extracting total polysaccharides from Hosta flowers using water extraction:

[0049] The dried Mongolian medicine hosta flower is selected as a raw material, the dried hosta flower is crushed into powder, the crushed hosta flower is put into distilled water for 6-8 hours to soften the plant cell wall so that the polysaccharide is dissolved, the soaked hosta flower and the water are heated to boiling, the cooking time is 1-2 hours, and the extraction process is repeated 2-3 times, and new distilled water is used each time;

[0050] The extracted mixed solution was cooled to room temperature, and the cooled extract was centrifuged at a speed of 4000-6000 rpm for 10-20 min to remove insoluble impurities to obtain a supernatant;

[0051] The supernatant after centrifugation is concentrated by a vacuum concentration device to remove most of the water to obtain a polysaccharide concentrate, the concentrate is preliminarily purified by a DEAE-cellulose ion exchange column, the preliminarily purified polysaccharide solution is further purified by gel filtration chromatography to separate polysaccharides with different molecular weights to obtain polysaccharide components, the collected polysaccharide solution is dialyzed using a dialysis bag, and the dialyzed polysaccharide solution is freeze-dried to obtain a dry polysaccharide powder.

[0052] Gradient elution steps:

[0053] Prepare the ion exchange column: First prepare the DEAE-cellulose ion exchange column and make sure the column is properly packed and equilibrated.

[0054] Loading: Load the concentrated polysaccharide solution onto the equilibrated DEAE-cellulose column.

[0055] Wash: After loading the sample, wash the column with a low ionic strength starting buffer to remove unbound proteins and other impurities.

[0056] Gradient preparation: Prepare buffer containing 0.1M, 0.2M, 0.3M, and 0.5M NaCl.

[0057] Gradient elution: When starting gradient elution, first use a buffer with low ionic strength and gradually transition to a buffer with high ionic strength.

[0058] Linear gradient elution: gradually increase the salt concentration in the buffer, i.e. start from 0.1 M NaCl and increase by 0.1 M every 10 column volumes until reaching 0.5 M NaCl.

[0059] Nonlinear gradient elution: During gradient elution, the salt concentration increases slowly at low ionic strength and increases rapidly at high ionic strength.

[0060] Collect fractions: During gradient elution, different polysaccharides elute from the column at different ionic strengths. Collect fractions at different time points and monitor their absorbance.

[0061] Detection and analysis: The collected fractions were subjected to high performance liquid chromatography and mass spectrometry to determine the content and purity of the polysaccharide. Based on the test results, the fractions with higher purity were combined.

[0062] The steps of further purifying the polysaccharide solution after preliminary purification by gel filtration chromatography:

[0063] Prepare the gel column: Use a 1.5 cm x 100 cm chromatography column and pre-treat the Sephadex G-100 gel before loading it into the column.

[0064] Equilibrate the column: Use 0.02 M ammonium acetate buffer (pH 7.0) to equilibrate the gel column until the pH and conductivity of the buffer are stable.

[0065] Loading: Slowly add the preliminarily purified polysaccharide solution to the gel column through a syringe, and control the loading volume not to exceed 5-10% of the total capacity of the gel column.

[0066] Elution: Continue to use 0.02 M ammonium acetate buffer (pH 7.0) for elution, and control the flow rate at 0.5-1 mL / min.

[0067] Collect fractions: Collect 10 mL of eluate and record the volume of each fraction.

[0068] Detection and analysis: The sugar content of the collected fractions was determined by the phenol-sulfuric acid method, and the characteristics of the polysaccharides were analyzed by UV-Vis spectroscopy.

[0069] Step 2: Mix the prepared raw materials and emulsify the mixture using a high-speed shear emulsifier. The mixing time of the raw materials is 10-20 minutes, the speed of the emulsifier is 1000-10000 rpm, and the emulsification time is 3-10 minutes.

[0070] Step 3: Place the emulsified mixture in a vacuum drying oven to slowly dry and remove moisture. The temperature of the drying oven is set at 40-60° C. The drying is stopped when the water content of the mixture is less than 5%.

[0071] Step 4: Crush the dried material, pass it through an 80-mesh sieve to obtain powder, mix the powder with magnesium stearate, and finally, use a tablet press to press it into lozenges.

[0072] Experimental Example 1

[0073] Experimental purpose: To compare the throat-clearing and throat-removing effects and taste of the lozenges prepared by the present invention and traditional lozenges (without the Mongolian medicine Hosta floridula water extract).

[0074] Experimental materials: The experimental group was given lozenges prepared according to this protocol, and the control group was given lozenges prepared according to the traditional method.

[0075] Subjects: 40 healthy adults were randomly selected as subjects.

[0076] Experimental steps:

[0077] Step 1: Prepare lozenges according to the steps of this protocol as the experimental group, and prepare lozenges using the traditional method as the control group.

[0078] Step 2: Divide the subjects into two groups, with 20 people in each group. Ask the two groups of subjects to taste the lozenges of the experimental group and the control group respectively, and collect the subjects' scores on taste, dissolution speed, and throat clearing effect, with a score of 1-10, with 10 being the highest.

[0079] Step 3: Ask the subjects to use the lozenges when they feel throat discomfort and record the throat comfort score within 1 hour after use, with a score of 1-10, with 10 being the highest.

[0080] Experimental data:

[0081] The sensory evaluation results are shown in the following table:

[0082]

[0083] The evaluation results of the throat clearing effect are shown in the following table:

[0084] Group Throat comfort score (average) Experimental Group 8.4 Control group 6.9

[0085] According to the above experimental data, it can be seen that the experimental group is superior to the control group in terms of taste, dissolution speed and throat clearing effect, indicating that the lozenge prepared by the present invention has obvious advantages in sensory experience and efficacy.

[0086] Parts not involved in the present invention are the same as the prior art or can be implemented by the prior art. Although the embodiments of the present invention have been shown and described, it is understood by those skilled in the art that various changes, modifications, substitutions and variations can be made to these embodiments without departing from the principles and spirit of the present invention, and the scope of the present invention is defined by the appended claims and their equivalents.

Claims

1. A throat clearing lozenge, characterized in that: The lozenge candy comprises the following raw material components in parts by weight: 10-15 parts of Mongolian medicine Hosta flower water extract; 2-5 parts of pear powder; 5-15 parts of raisins; Rock sugar: 5-15 parts; Honey: 5-15 portions; Preservatives: 0.6-1.5 parts.

2. The throat-clearing lozenge according to claim 1, characterized in that: The water extract of Mongolian medicine Hosta odorata is total polysaccharide.

3. The throat-clearing lozenge according to claim 1, characterized in that: The preservative is one or more of sodium benzoate and citric acid.

4. A method for preparing a throat-clearing lozenge, characterized in that: The following steps are involved: Step 1: prepare and pretreat pear powder, total polysaccharides, raisins and crystal sugar; Step 2: Mix the prepared raw materials and emulsify the mixture using a high-speed shear emulsifier; Step 3: placing the emulsified mixture in a vacuum drying oven to slowly dry and remove moisture; Step 4: Crush the dried material, pass it through an 80-mesh sieve to obtain powder, mix the powder with magnesium stearate, and finally, use a tablet press to press it into lozenges.

5. The method for preparing the throat-clearing lozenge according to claim 4, characterized in that: Specific steps for extracting total polysaccharides from Hosta flowers using water extraction: The dried Mongolian medicine hosta flower is selected as a raw material, the dried hosta flower is crushed into powder, the crushed hosta flower is put into distilled water for 6-8 hours to soften the plant cell wall so that the polysaccharide is dissolved, the soaked hosta flower and the water are heated to boiling, the cooking time is 1-2 hours, and the extraction process is repeated 2-3 times, and new distilled water is used each time; The extracted mixed solution was cooled to room temperature, and the cooled extract was centrifuged at a speed of 4000-6000 rpm for 10-20 min to remove insoluble impurities to obtain a supernatant; The supernatant after centrifugation is concentrated by a vacuum concentration device to remove most of the water to obtain a polysaccharide concentrate, the concentrate is preliminarily purified by a DEAE-cellulose ion exchange column, the preliminarily purified polysaccharide solution is further purified by gel filtration chromatography to separate polysaccharides with different molecular weights to obtain polysaccharide components, the collected polysaccharide solution is dialyzed using a dialysis bag, and the dialyzed polysaccharide solution is freeze-dried to obtain a dry polysaccharide powder.

6. The method for preparing the throat-clearing lozenge according to claim 4, characterized in that: In step 2, the mixing time of the raw materials is 10-20 minutes, the rotation speed of the emulsifier is 1000-10000 rpm, and the emulsification time is 3-10 minutes.

7. The throat-clearing lozenge and preparation method thereof according to claim 4, characterized in that: In step three, the temperature of the drying oven is set at 40-60° C., and the drying is stopped when the water content of the mixture is lower than 5%.

Images