Intelligent constant-temperature perfusion system for organ transplantation and isolated organ repair

Abstract

The invention discloses an intelligent constant-temperature perfusion system for organ transplantation and isolated organ repair, which is characterized in that the liquid outlet end of a perfusion blood bag is connected with the liquid inlet end of a total input blood pump, and the liquid outlet end of the total input blood pump is connected with the input end of an oxygenator; the output end of the oxygenator is divided into two paths which are respectively connected to the liquid inlet ends of a first input blood pump and a second input blood pump, and the liquid outlet ends of the first input blood pump and the second input blood pump are respectively connected with the hepatic artery inlet and the portal vein inlet of the organ container through an ultrasonic flowmeter and a pressure transmitter; the inferior vena cava outlet of the organ container is connected with the liquid inlet end of the total output blood pump through a pipeline with an ultrasonic flowmeter, and the liquid outlet end of the total output blood pump is connected with the perfusion blood bag to form circulation. By means of the scheme, external blood circulation equipment can be conveniently maintained, and blood mechanical injuries caused by long-time perfusion are reduced.

Description

Technical Field

[0001] The present application relates to the field of organ perfusion, and in particular to an intelligent constant temperature perfusion system for organ transplantation and ex vivo organ repair. Background Art

[0002] In recent years, the incidence of cardiovascular disease has increased significantly worldwide, especially in low- and middle-income countries, where the growth trend is more obvious. This phenomenon is mainly attributed to multiple factors such as poor eating habits, increased environmental pollution, and an aging society. Cardiovascular disease has become one of the main causes of threat to public health, placing a heavy burden on individuals, families, and the medical system. In this context, in order to alleviate the condition of patients with cardiovascular disease, especially those with end-stage heart failure, the application of organ perfusion technology has received increasing attention. The main function of organ perfusion is to provide additional blood and oxygen supply to the patient's damaged or dysfunctional organs, and to maintain the normal metabolic function of the organs by improving the local blood perfusion state. This technology is widely used in the supportive treatment of important organs such as the heart, kidneys, and liver, especially in intensive care and organ transplantation surgery. For patients with organ failure, organ perfusion technology provides them with a precious opportunity to prolong their lives, and it is also of great significance in organ preservation and transportation.

[0003] At present, with the continuous advancement of medical technology, organ perfusion technology has gradually developed from traditional manual operation to a precise control system that relies on advanced equipment. Modern organ perfusion equipment combines technologies from multiple fields such as fluid mechanics, mechanical engineering and biomedicine to achieve real-time monitoring and regulation of blood flow velocity, pressure and oxygenation level. These systems can be used to support patients' organs during surgery and to maintain the activity of organs under in vitro conditions, creating conditions for transplantation and functional recovery. However, despite significant progress in related technologies, organ perfusion still faces many challenges in clinical practice. The current mainstream organ perfusion technologies mainly include extracorporeal membrane oxygenation (ECMO), centrifugal pump perfusion systems and multifunctional perfusion equipment. These technologies achieve efficient oxygen supply and nutrient delivery to organs by mimicking the characteristics of physiological blood circulation. However, in practical applications, existing technologies still have some inherent limitations. For example, blood may be subjected to non-physiological fluid shear force when passing through the perfusion equipment, resulting in red blood cell rupture and hemolysis; in addition, irregular blood flow patterns may also lead to platelet activation and thrombosis. These problems not only affect perfusion efficiency, but may also induce serious complications. At present, one of the most prominent problems facing organ perfusion technology in clinical applications is mechanical damage to the blood. Due to the complex flow field characteristics inside the device, the blood may experience unnatural mechanical stress during the perfusion process, which may damage the blood components and affect the functional recovery of the perfused organ. At the same time, the existing perfusion equipment still needs to be further optimized in terms of biocompatibility, energy consumption and long-term operational stability. For example, high power consumption may limit the use of equipment in resource-poor areas, and the lack of reliability and durability of the equipment also poses a challenge to its application in long-term support. These problems restrict the widespread popularization and clinical promotion of organ perfusion technology.

[0004] Therefore, there is an urgent need for a technical solution that can facilitate the maintenance of extracorporeal blood circulation equipment and reduce mechanical damage to blood under long-term perfusion. Summary of the invention

[0005] In order to solve the deficiencies of the prior art, the embodiment of the present application provides an intelligent constant temperature perfusion system for organ transplantation and ex vivo organ repair. The present application solves the technical problems that the prior art perfusion equipment is not easy to repair and long-term perfusion may cause mechanical damage to the blood.

[0006] An embodiment of the present application provides an intelligent constant temperature perfusion system for organ transplantation and ex vivo organ repair, comprising: an internal circulation system of a box and an external control system of the box; wherein the internal circulation system of the box comprises a perfusion blood bag, a total input blood pump, an oxygenator, a first input blood pump, a second input blood pump, one or more ultrasonic flow meters, a pressure transmitter, an organ container and a total output blood pump; the external control system of the box comprises a power conversion board, a main control board, a data acquisition board, an air-cooled compressor, a drive device, a touch display screen, a battery pack and an inverter.

[0007] In a possible implementation, the connection method of the internal circulation system of the box includes: the liquid outlet of the perfusion blood bag is connected to the liquid inlet of the total input blood pump, the liquid outlet of the total input blood pump is connected to the input end of the oxygenator, the output end of the oxygenator is divided into two paths and respectively connected to the liquid inlet of the first input blood pump and the second input blood pump, the liquid outlets of the first input blood pump and the second input blood pump are respectively connected to the hepatic artery inlet and the portal vein inlet of the organ container through an ultrasonic flowmeter and a pressure transmitter, the inferior vena cava outlet of the organ container is connected to the liquid inlet of the total output blood pump through a pipeline with an ultrasonic flowmeter, and the liquid outlet of the total output blood pump is connected to the perfusion blood bag to form a circulation.

[0008] In a possible implementation, the internal circulation system of the box further includes: one or more temperature sensors, which are arranged at the perfusion blood bag and / or the organ container and are used to collect temperature data and transmit it to the data acquisition board.

[0009] In a possible implementation, the ultrasonic flowmeters in the internal circulation system of the box are respectively arranged at the liquid outlet of the first input blood pump, the liquid outlet of the second input blood pump and the liquid outlet of the total output blood pump, for collecting the flow data of each pipeline and transmitting it to the data acquisition board.

[0010] In a possible implementation, the pressure transmitter in the internal circulation system of the box is a sanitary diaphragm type, which is respectively arranged on the pipelines leading to the hepatic artery and the portal vein, and is used to collect perfusion pressure data and transmit it to the data acquisition board.

[0011] In a possible implementation, the total input blood pump, the first input blood pump, and the second input blood pump are diaphragm pumps.

[0012] In a possible implementation, the organ container is provided with a hepatic artery inlet, a portal vein inlet and an inferior vena cava outlet.

[0013] In a possible implementation, the connection method of the external control system of the box includes: the power conversion board is electrically connected to the main control board and the drive device, the main control board is connected to the data acquisition board through a data bus, the data acquisition board is connected to the temperature sensor, ultrasonic flow meter, and pressure transmitter signals, the drive device is electrically connected to each blood pump, the touch display screen is communicatively connected to the main control board, and the battery pack is connected to the power conversion board through an inverter.

[0014] In a possible implementation, the control end of the air-cooled compressor in the control system outside the box is connected to the main control board, and the refrigerant pipeline is connected to the heat exchanger inside the box.

[0015] In a possible implementation, the information interaction method between the internal circulation system of the box and the external control system of the box includes: the data collected by the temperature sensor, ultrasonic flow meter, and pressure transmitter are transmitted to the main control board through the data acquisition board; the control instructions of the main control board are transmitted to the blood pump through the drive device; the touch screen displays the system operation status in real time and receives operation instructions; the air-cooled compressor adjusts the internal temperature of the box according to the feedback from the temperature sensor.

[0016] In the intelligent constant temperature perfusion system for organ transplantation and ex vivo organ repair provided above, the embodiments of the present application can reduce the failure rate of extracorporeal blood circulation equipment by integrating a modular dual-circuit perfusion system. Furthermore, in some embodiments, the mechanical damage of blood under long-term perfusion can be reduced by an improved diaphragm pump structure. BRIEF DESCRIPTION OF THE DRAWINGS

[0017] In order to more clearly illustrate the embodiments of the present application or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of the present application. For ordinary technicians in this field, other drawings can be obtained based on these drawings without paying any creative work.

[0018] Figure 1 A schematic block diagram of an intelligent constant temperature perfusion system for organ transplantation and ex vivo organ repair provided in an embodiment of the present application;

[0019] Figure 2 A schematic block diagram of a dual-circuit integrated perfusion system for organ transplantation and ex vivo organ repair provided in an embodiment of the present application;

[0020] Figure 3 A schematic diagram of the effect of a double-layer diaphragm diaphragm pump provided in an embodiment of the present application. DETAILED DESCRIPTION

[0021] Various exemplary embodiments of the present disclosure will now be described in detail with reference to the accompanying drawings. It should be noted that the relative arrangement of components and steps, numerical expressions and numerical values ​​set forth in these embodiments do not limit the scope of the present disclosure unless otherwise specifically stated.

[0022] Those skilled in the art can understand that the terms "first", "second" and the like in the embodiments of the present disclosure are only used to distinguish different steps, devices or modules, etc., and neither represent any specific technical meaning nor represent the necessary logical order between them. It should also be understood that in the embodiments of the present disclosure, "multiple" can refer to two or more, and "at least one" can refer to one, two or more. It should also be understood that for any component, data or structure mentioned in the embodiments of the present disclosure, in the absence of explicit limitation or contrary revelation given in the context, it can generally be understood as one or more. In addition, the term "and / or" in the present disclosure is only a description of the association relationship of the associated objects, indicating that there can be three relationships, for example, A and / or B can represent: A exists alone, A and B exist at the same time, and B exists alone. In addition, the character " / " in the present disclosure generally indicates that the associated objects before and after are an "or" relationship. It should also be understood that the description of each embodiment in the present disclosure emphasizes the differences between the embodiments, and the same or similar parts can refer to each other. For the sake of brevity, they will not be repeated one by one.

[0023] At the same time, it should be understood that, for ease of description, the sizes of the various parts shown in the drawings are not drawn according to the actual proportional relationship. The following description of at least one exemplary embodiment is actually only illustrative and is by no means intended to limit the present disclosure and its application or use. The techniques, methods and devices known to ordinary technicians in the relevant fields may not be discussed in detail, but where appropriate, the techniques, methods and devices should be considered part of the specification. It should be noted that similar numbers and letters represent similar items in the following drawings, so once an item is defined in one drawing, it does not need to be further discussed in subsequent drawings.

[0024] In order to make the purpose, technical solution and advantages of the embodiments of the present application clearer, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of this application.

[0025] Figure 1A schematic block diagram of an intelligent constant temperature perfusion system for organ transplantation and ex vivo organ repair provided in an embodiment of the present application. It should be understood that the system shown in the figure is exemplary and not restrictive. This means that the system architecture involved is not limited to a specific form or design, but is presented as an example. In other words, the architecture shown in the figure can be regarded as a way of expression to clearly describe related concepts and relationships, and does not exclude other forms of architecture. Therefore, when interpreting the architecture in the picture, it should be understood that the model is flexible and diverse, and its purpose is to provide an exemplary description rather than a restrictive provision on a specific form.

[0026] Specifically, an embodiment of the present application discloses an intelligent constant temperature perfusion system for organ transplantation and ex vivo organ repair, comprising: an internal circulation system 100 of the box and an external control system 200 of the box; wherein the internal circulation system 100 of the box comprises a perfusion blood bag 101, a total input blood pump 102, an oxygenator 103, a first input blood pump 104, a second input blood pump 105, one or more ultrasonic flow meters 106, a pressure transmitter 107, an organ container 108 and a total output blood pump 109; the external control system 200 of the box comprises a power conversion board 201, a main control board 202, a data acquisition board 203, an air-cooled compressor 204, a drive device 205, a touch display screen 206, a battery pack 207 and an inverter 208.

[0027] In one embodiment, the connection mode of the internal circulation system 100 of the box includes: the liquid outlet of the perfusion blood bag 101 is connected to the liquid inlet of the total input blood pump 102, the liquid outlet of the total input blood pump 102 is connected to the input end of the oxygenator 103, the output end of the oxygenator 103 is divided into two paths and respectively connected to the liquid inlets of the first input blood pump 104 and the second input blood pump 105, the liquid outlets of the first input blood pump 104 and the second input blood pump 105 are respectively connected to the hepatic artery inlet and the portal vein inlet of the organ container 108 through the ultrasonic flowmeter 106 and the pressure transmitter 107, the inferior vena cava outlet of the organ container 108 is connected to the liquid inlet of the total output blood pump 109 through the pipeline with the ultrasonic flowmeter 106, and the liquid outlet of the total output blood pump 109 is connected to the perfusion blood bag 101 to form a circulation.

[0028] In yet another embodiment, the internal circulation system 100 of the box further includes: one or more temperature sensors 301 , wherein the temperature sensors 301 are disposed at the perfusion blood bag 101 and / or the organ container 108 , and are used to collect temperature data and transmit the temperature data to the data acquisition board 203 .

[0029] Preferably, the ultrasonic flowmeter 106 in the internal circulation system 100 of the box is respectively arranged at the liquid outlet of the first input blood pump 104, the liquid outlet of the second input blood pump 105 and the liquid outlet of the total output blood pump 109, for collecting the flow data of each pipeline and transmitting it to the data acquisition board 203.

[0030] Preferably, the pressure transmitter 107 in the internal circulation system 100 of the box is a sanitary diaphragm type, which is respectively arranged on the pipelines leading to the hepatic artery and the portal vein, and is used to collect perfusion pressure data and transmit it to the data acquisition board 203. The total input blood pump 102, the first input blood pump 104, and the second input blood pump 105 are diaphragm pumps. The organ container 108 is provided with a hepatic artery inlet, a portal vein inlet, and an inferior vena cava outlet.

[0031] Furthermore, in a preferred embodiment, the internal circulation module of the system adopts multiple protection mechanisms. First, multiple temperature sensors are set in the system, which are located at the perfusion blood bag, the output end of the oxygenator and the return of the inferior vena cava, forming a complete temperature monitoring network to ensure that the perfusion fluid is always maintained in the optimal temperature range of 3.8°C to 4.2°C. Secondly, a total input blood pump with a diaphragm pump structure is equipped on the blood circulation path. The operating frequency of the pump can be accurately adjusted within the range of 60-180 times / minute, and the pumping flow rate can reach 0-2.5L / min. It is also equipped with a dedicated blood pump using a diaphragm pump. This design can effectively reduce the blood cell destruction rate.

[0032] In the specific implementation of organ perfusion, the system adopts a dual-parallel input structure. The first input blood pump and the second input blood pump control the perfusion of the hepatic artery and the portal vein respectively. This design can independently adjust the perfusion parameters of the two blood vessels according to the specific needs of different organs. For example, in the liver perfusion scenario, the perfusion pressure of the hepatic artery is usually maintained at 60-100mmHg, while the portal vein is maintained in the physiological pressure range of 8-12mmHg. Each perfusion branch is equipped with an ultrasonic flowmeter and a pressure transmitter to monitor flow and pressure changes in real time, with an accuracy of ±0.5% and ±0.1% respectively.

[0033] The oxygenator can be a hollow fiber membrane oxygenator with an effective membrane area of ​​1.5-2.0m 2 , gas exchange efficiency ≥ 98%. The oxygenator is provided with an air inlet and an air outlet at both ends, and the oxygen partial pressure is maintained within the range of 80-100 mmHg through a precise gas flow control system. In some embodiments, the oxygenator can also be equipped with an optional CO2 monitoring module to adjust the CO2 partial pressure in real time to maintain it within the physiological range of 35-45 mmHg.

[0034] The organ container can be made of medical grade transparent material to facilitate observation of the organ status. The inlet and outlet of the container are respectively connected to the hepatic artery, portal vein and inferior vena cava, and a quick-connect connector is used to facilitate loading and unloading of the organ. In some embodiments, the organ container can also be equipped with a miniature camera to record the morphological changes of the organ during storage.

[0035] In one embodiment, the connection method of the external control system 200 of the box includes: the power conversion board 201 is electrically connected to the main control board 202 and the drive device 205, the main control board 202 is connected to the data acquisition board 203 through a data bus, the data acquisition board 203 is signal-connected to the temperature sensor 301, the ultrasonic flow meter 106, and the pressure transmitter 107, the drive device 205 is electrically connected to each blood pump, the touch display screen 206 is communicatively connected to the main control board 202, and the battery pack 207 is connected to the power conversion board 201 through the inverter 208.

[0036] Preferably, the control end of the air-cooled compressor 204 in the external control system 200 of the box is connected to the main control board 202, and the refrigerant pipeline is connected to the heat exchanger inside the box.

[0037] In one implementation scenario, the information interaction method between the internal circulation system 100 of the box and the external control system 200 of the box includes: the data collected by the temperature sensor 301, the ultrasonic flow meter 106, and the pressure transmitter 107 are transmitted to the main control board 202 through the data acquisition board 203; the control instructions of the main control board 202 are transmitted to the blood pump through the drive device 205; the touch display screen 206 displays the system operation status in real time and receives operation instructions; the air-cooled compressor 204 adjusts the internal temperature of the box according to the feedback from the temperature sensor 301.

[0038] Furthermore, in terms of the control system, the power conversion board can use a medical-grade switching power supply with an input voltage range of 100-240V AC, which can adapt to the power supply standards of different regions. The main control board can use a 32-bit high-performance microprocessor with a main frequency of up to 180MHz and real-time multi-tasking capabilities. The controller communicates with each functional module through the CAN bus, and the sampling rate of the data acquisition board can reach 1kHz, ensuring the real-time and accuracy of the system operation data.

[0039] The refrigeration system uses an air-cooled compressor with a cooling power of 1.5-2.0kW, and can work stably in an ambient temperature range of -20°C to 45°C. In a specific embodiment, the start and stop of the compressor is regulated by a PID control algorithm, and the temperature control accuracy is better than ±0.1°C. At the same time, the system is equipped with a complete thermal management solution, including air duct design and heat conduction system, which can ensure uniform temperature distribution in the box and control the temperature difference within ±0.3°C.

[0040] The human-machine interface uses a 10.1-inch capacitive touch screen with a resolution of 1280×800 pixels, which can display all system operating parameters, including but not limited to real-time data and historical trend charts of key indicators such as temperature, pressure, and flow. In an emergency, the system will alert the operator through sound and light alarms.

[0041] To ensure power supply reliability, the system is equipped with a 12V / 40Ah lithium battery pack, which can provide no less than 4 hours of backup power. The inverter is rated at 2000W and has multiple protection functions such as overvoltage, undervoltage, and overload. In the event of a power outage, the system can automatically switch to battery power with a switching time of less than 10ms to ensure the continuity of organ perfusion.

[0042] In some implementations, the system can also be equipped with a remote monitoring module, which transmits operating data to a cloud server in real time via a 4G / 5G network, making it easier for the medical team to remotely monitor the operating status of the equipment. At the same time, the system supports online software upgrades and continuously optimizes the control algorithm and user interface.

[0043] Considering the safety of the system, redundant protection is set for each key component. For example, the temperature sensor adopts a triple redundant design, and the failure of any sensor will not affect the normal operation of the system. The pressure monitoring system is set with over-limit protection. When the pressure exceeds the preset threshold, the system will automatically adjust the pump speed or cut off the liquid supply.

[0044] Figure 2 A schematic block diagram of a dual-pipeline integrated perfusion system for organ transplantation and ex vivo organ repair provided in an embodiment of the present application. The pipeline system in the embodiment of the present application adopts a modular integrated design, including two major parts: a pipeline module for ex vivo organs and a nutrient solution delivery management module.

[0045] In one embodiment, the first part of the ex vivo organ pipeline module connects the inlet and outlet of the organ container, including: a pipeline from the first input blood pump to the hepatic artery inlet of the organ container; a pipeline from the second input blood pump to the portal vein inlet of the organ container; and a pipeline from the inferior vena cava outlet of the organ container to the total output blood pump.

[0046] This part of the pipeline can be made of medical grade silicone material, with a wall thickness of 1.6±0.1mm and an inner diameter of 6.4±0.2mm. The pipeline is designed to be detachable, and all joints are equipped with bayonet-type quick connectors. The surface of the connector is plasma treated, and the contact angle is less than 15° to ensure sterile sealing. The inner surface of the pipeline is heparinized, and the heparin grafting density reaches 15-20μg / cm 2 , which can effectively prevent thrombosis. In practical applications, the pipeline components are sterilized with ethylene oxide and provided in sterile packaging, which can be quickly loaded, unloaded and replaced when in use.

[0047] The organ container can be made of medical-grade PMMA material, which has good biocompatibility and transparency. The specific dimensions of the container are 320mm long × 240mm wide × 80mm high, and a flat design is adopted to ensure that the organ is evenly stressed. A micro-raised support grid is provided at the bottom of the container, with a grid spacing of 8.5mm and a height of 2.3mm, which can prevent the organ from directly contacting the bottom of the container and facilitate the uniform distribution of the perfusion fluid. A serpentine refrigeration pipe is embedded in the container wall, and a refrigerant with a temperature of 2.8°C is passed into the pipe. The temperature in the container is kept constant at 4.0±0.2°C through convection heat exchange.

[0048] In one embodiment, the second part of the nutrient solution delivery management module includes: a pipeline from the perfusion blood bag to the total input blood pump; a pipeline from the total input blood pump to the oxygenator; a branch pipeline from the oxygenator to the input blood pump 1 and the input blood pump 2; and a loop pipeline from the total output blood pump back to the perfusion blood bag.

[0049] This part of the pipeline can be made of medical grade silicone material and adopts a closed loop design. The perfusion blood bag is made of medical grade EVA material, with a capacity of 450ml, and is placed in a constant temperature environment of 4°C. The outside of the blood bag is coated with an inflatable silicone airbag, which is connected to a medical grade nitrogen cylinder through a precision pressure reducing valve. In actual use, the inflation pressure of the airbag is adjusted to the range of 23.5-26.8kPa, and the airbag is used to apply uniform pressure to the liquid storage bag, replacing the traditional roller extrusion method, which significantly reduces the mechanical damage to the blood.

[0050] In another embodiment, a bile collection device may be provided. The collection container is a graduated conical structure, with a bottom inner diameter of 15.2 mm, a top inner diameter of 38.5 mm, and a height of 82.6 mm. The container is connected to the bile duct outlet of the organ container through a quick-screw joint, and the bile secretion can be collected and measured in real time during the perfusion process.

[0051] Figure 3 A schematic diagram of the effect of a double-layer diaphragm diaphragm pump provided in an embodiment of the present application. Further, specifically, in order to solve the problem of mechanical damage to blood during extracorporeal circulation, in one embodiment, the embodiment of the present application may adopt a double-layer diaphragm diaphragm pump structure. The core of this structure is the use of an upper and lower double-layer PTFE diaphragm design with a diaphragm thickness of 0.22±0.01mm and an effective diameter of 68.5mm. The upper diaphragm is in direct contact with the liquid cavity and is made of modified PTFE material. After the surface is treated with plasma, the contact angle is less than 5°, which can significantly reduce blood cell adhesion; the lower diaphragm is made of reinforced PTFE composite material, which has excellent mechanical strength and fatigue resistance.

[0052] The diaphragm is driven by pneumatic control, and the driving gas is medical grade nitrogen. The relationship between the driving cavity volume and the diaphragm displacement can be expressed as: V = V0 × [1-(h / h0)2 × (3-2h / h0)], where V0 is the initial cavity volume (125ml), h is the diaphragm center displacement, and h0 is the maximum stroke (4.8mm). Through this nonlinear design, the uniform speed characteristics of the diaphragm during movement can be achieved.

[0053] The flow characteristics of blood in the pump are described by the modified Bernoulli equation: P1 / ρg+v1 2 / 2g+z1=P2 / ρg+v2 2 / 2g+z2+hl, where P is pressure, v is flow rate, z is position head, and hl is loss head. After calculation and optimization, at an operating frequency of 48-72 times / minute, the maximum shear stress in the pump can be controlled below 125Pa, which is far below the critical damage threshold of red blood cells (400Pa).

[0054] In order to achieve accurate flow control, the diaphragm pump is driven by a fuzzy PID algorithm. The control rules for the output flow are as follows:

[0055] If q is the flow deviation and qc is the deviation change rate, the actuator output is adjusted as follows:

[0056] P=P0×(1+0.28×|q|+0.12×|qc|);

[0057] τ=τ0×(1-0.25×|q|-0.15×|qc|),

[0058] Where P is the driving gas pressure, τ is the driving period, and P0 and τ0 are the reference parameter values. This control strategy can control the output flow fluctuation of the pump within ±2.8%.

[0059] To further optimize the blood flow characteristics, the pump inlet and outlet can adopt a gradual flow channel design. The cross-sectional area of ​​the flow channel changes according to the exponential law: A(x) = A0×[1+(x / L) 2 ], where A0 is the inlet cross-sectional area (28.3mm 2 ), L is the flow channel length (42.6 mm), and x is the distance along the path. This design allows the pressure gradient of blood to change smoothly during flow, avoiding the formation of local high shear areas.

[0060] Furthermore, an embodiment of the present application also provides a perfusion control device, comprising: a processor, a memory, and a system bus; the processor and the memory are connected via the system bus; the memory is used to store one or more programs, and the one or more programs include instructions, which, when executed by the processor, enable the processor to execute any of the above methods.

[0061] Furthermore, an embodiment of the present application also provides a computer program product, which, when executed on a terminal device, enables the terminal device to execute any of the above methods.

[0062] It can be known from the description of the above implementation mode that those skilled in the art can clearly understand that all or part of the steps in the above-mentioned embodiment method can be implemented by means of software plus a necessary general hardware platform. Based on such an understanding, the technical solution of the present application can be essentially or partly embodied in the form of a software product that contributes to the prior art. The computer software product can be stored in a storage medium such as ROM / RAM, a disk, an optical disk, etc., including several instructions for enabling a computer device (which can be a personal computer, a server, or a network communication device such as a media gateway, etc.) to execute the methods described in the various embodiments of the present application or certain parts of the embodiments.

[0063] It should be noted that the various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments, and the same or similar parts between the various embodiments can be referred to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant parts can be referred to the method part description.

[0064] It should also be noted that, in this article, relational terms such as first and second, etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations. Moreover, the terms "include", "comprise" or any other variants thereof are intended to cover non-exclusive inclusion, so that a process, method, article or device including a series of elements includes not only those elements, but also other elements not explicitly listed, or also includes elements inherent to such process, method, article or device. In the absence of further restrictions, the elements defined by the sentence "comprise a ..." do not exclude the presence of other identical elements in the process, method, article or device including the elements.

[0065] The above description of the disclosed embodiments enables those skilled in the art to implement or use the present application. Various modifications to these embodiments will be apparent to those skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present application. Therefore, the present application will not be limited to the embodiments shown herein, but will conform to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. An intelligent constant temperature perfusion system for organ transplantation and ex vivo organ repair, characterized in that: include: The internal circulation system (100) of the box and the external control system (200) of the box; wherein, The internal circulation system (100) of the box includes a perfusion blood bag (101), a total input blood pump (102), an oxygenator (103), a first input blood pump (104), a second input blood pump (105), one or more ultrasonic flow meters (106), a pressure transmitter (107), an organ container (108) and a total output blood pump (109); The box external control system (200) comprises a power conversion board (201), a main control board (202), a data acquisition board (203), an air-cooled compressor (204), a drive device (205), a touch display screen (206), a battery pack (207) and an inverter (208).

2. The intelligent constant temperature perfusion system according to claim 1, characterized in that: in, The connection method of the internal circulation system (100) of the box body includes: The liquid outlet of the perfusion blood bag (101) is connected to the liquid inlet of the total input blood pump (102), the liquid outlet of the total input blood pump (102) is connected to the input end of the oxygenator (103), the output end of the oxygenator (103) is divided into two paths and respectively connected to the liquid inlets of the first input blood pump (104) and the second input blood pump (105), the liquid outlets of the first input blood pump (104) and the second input blood pump (105) are respectively connected to the hepatic artery inlet and the portal vein inlet of the organ container (108) through an ultrasonic flowmeter (106) and a pressure transmitter (107), the inferior vena cava outlet of the organ container (108) is connected to the liquid inlet of the total output blood pump (109) through a pipeline with an ultrasonic flowmeter (106), and the liquid outlet of the total output blood pump (109) is connected to the perfusion blood bag (101) to form a circulation.

3. The intelligent constant temperature perfusion system according to claim 2, characterized in that: in, The internal circulation system (100) of the box body further comprises: One or more temperature sensors (301), wherein the temperature sensors (301) are arranged at the perfusion blood bag (101) and / or the organ container (108), and are used to collect temperature data and transmit the temperature data to the data collection board (203).

4. The intelligent constant temperature perfusion system according to claim 3, characterized in that: in, The ultrasonic flowmeter (106) in the internal circulation system (100) of the box is respectively arranged at the liquid outlet of the first input blood pump (104), the liquid outlet of the second input blood pump (105) and the liquid outlet of the total output blood pump (109), and is used to collect flow data of each pipeline and transmit it to the data acquisition board (203).

5. The intelligent constant temperature perfusion system according to claim 4, characterized in that: in, The pressure transmitter (107) in the internal circulation system (100) of the box is of sanitary diaphragm type and is respectively arranged on the pipelines leading to the hepatic artery and the portal vein, and is used to collect perfusion pressure data and transmit it to the data acquisition board (203).

6. The intelligent constant temperature perfusion system according to claim 5, characterized in that: in, The total input blood pump (102), the first input blood pump (104), and the second input blood pump (105) are diaphragm pumps.

7. The intelligent constant temperature perfusion system according to claim 6, characterized in that: in, The organ container (108) is provided with a hepatic artery inlet, a portal vein inlet and an inferior vena cava outlet.

8. The intelligent constant temperature perfusion system according to claim 1, characterized in that: in, The connection method of the cabinet external control system (200) includes: The power conversion board (201) is electrically connected to the main control board (202) and the driving device (205); the main control board (202) is connected to the data acquisition board (203) via a data bus; the data acquisition board (203) is signal-connected to the temperature sensor (301), the ultrasonic flow meter (106), and the pressure transmitter (107); the driving device (205) is electrically connected to each blood pump; the touch display screen (206) is communicatively connected to the main control board (202); and the battery pack (207) is connected to the power conversion board (201) via an inverter (208).

9. The intelligent constant temperature perfusion system according to claim 8, characterized in that: in, The control end of the air-cooled compressor (204) in the external control system (200) of the box is connected to the main control board (202), and the refrigerant pipeline is connected to the heat exchanger inside the box.

10. The intelligent constant temperature perfusion system according to claim 9, characterized in that: in, The information interaction method between the internal circulation system (100) of the box and the external control system (200) of the box includes: The data collected by the temperature sensor (301), the ultrasonic flow meter (106) and the pressure transmitter (107) are transmitted to the main control board (202) via the data acquisition board (203); The control instructions of the main control board (202) are transmitted to the blood pump via the driving device (205); The touch screen (206) displays the system operation status in real time and receives operation instructions; The air-cooled compressor (204) adjusts the internal temperature of the box according to the feedback from the temperature sensor (301).

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