Insecticidal composition and application thereof

Abstract

The invention relates to a sanitary insecticide, in particular to an insecticidal composition containing a methoxyl acrylate compound (Flupyroxystrobin) and oxadiazon and application of the insecticidal composition containing the methoxyl acrylate compound (Flupyroxystrobin) and the oxadiazon. The composition is a methoxy acrylate compound as shown in a formula I and oxadiazon, and the weight ratio of the methoxy acrylate compound to the oxadiazon is (1: 10)-(10: 1). The flupyroxystrobin and the oxadiazon are compounded and processed into wettable powder, water dispersible granules or a suspending agent, so that the use of an organic solvent is reduced, and the insecticidal composition is more environment-friendly and has an excellent lethal effect on public health pests. The compound insecticide is applied in a retention spraying mode, has a remarkable synergistic effect on prevention and treatment of public health pests, can reduce the application amount of the insecticide, saves the cost, delays the generation of pest resistance to drugs, and is widely applied to hotels, schools, factories, families, farmers, farms, public places and the like. Formula I # imgabs0 #

Description

Technical Field

[0001] The invention relates to a sanitary insecticide, in particular to an insecticide composition containing a methoxyacrylate compound (Flupyroxystrobin) and strobin and an application thereof. Background Art

[0002] Mefenamic acid has contact and stomach poison effects and good knockdown activity. It also has the dual characteristics of inhibiting acetylcholinesterase and nerve axon effects, and can effectively control sanitary pests, especially cockroaches that are resistant to pyrethroids.

[0003] Flupyroxystrobin is the first methoxyacrylate insecticide. Its presumed mechanism of action is a Qo mitochondrial respiration inhibitor. By inhibiting the respiration of the target pest's mitochondria, it inhibits the insect's energy synthesis and ultimately causes the insect's death.

[0004] Among the current residual spraying products in the external environment, the long-term and large-scale use of a single product has led to a large resistance of mosquitoes, flies, cockroaches and other pests, and in recent years, there has also been a general decline in the prevention effect. Therefore, environmentally friendly and efficient pesticide compound varieties are currently needed to delay the development of resistance in sanitary pests. Summary of the invention

[0005] The technical problem to be solved by the present invention is to provide an insecticide composition containing methoxyacrylate compound (Flupyroxystrobin) and flupyroxystrobin and application thereof in view of the deficiencies in the prior art.

[0006] In order to achieve the above object, the present invention adopts the following technical solution:

[0007] An insecticide composition, comprising a methoxyacrylate compound represented by formula I and mefenamic acid, wherein the weight ratio of the methoxyacrylate compound to mefenamic acid is 1:10 to 10:1;

[0008] Formula I is

[0009] Preferably, the weight ratio of the methoxyacrylate compound to mefenamic acid is 1:5 to 5:1.

[0010] An insecticide, which uses the composition as active ingredients and auxiliary materials; wherein the active ingredients account for 10% to 50% of the preparation mass.

[0011] The pesticide formulation is a wettable powder, a water dispersible granule or a suspension.

[0012] The wettable powder comprises 5% to 30% of an insecticide composition containing Flupyroxystrobin and oxadone, 1% to 10% of a dispersant, 1% to 5% of a wetting agent, and the filler is supplemented to 100%.

[0013] The water dispersible granules are composed of 10% to 50% of a compound insecticide composition containing flupyroxystrobin and mefenamic acid, 1% to 10% of a dispersant, 1% to 5% of a wetting agent, 1% to 10% of a disintegrant, 0.1% to 1% of a binder, and the filler is supplemented to 100%.

[0014] The suspension comprises, by weight, 5% to 30% of a compound insecticide composition containing flupyroxystrobin and mefenamic acid, 1% to 10% of a dispersant, 1% to 5% of a wetting agent, 0.1% to 1% of a thickener, 0.1% to 1% of a preservative, 3% to 10% of an antifreeze agent, 0.1% to 0.5% of a defoaming agent, and deionized water is added to make up to 100%.

[0015] The wettable powder is prepared by adding the insecticide composition containing flupyroxystrobin and mefenamic acid, a wetting agent, a dispersant and a filler into a food processor according to the proportion, mixing them evenly, and then putting them into a jet mill for pulverization to obtain the wettable powder.

[0016] The water dispersible granules are prepared by: adding the insecticide composition containing flupyroxystrobin and oxadone, a wetting agent, a dispersant, a disintegrant, a binder and a filler into a food processor according to the proportion, mixing them evenly, and then grinding them in a jet mill; putting the powder into a beaker, adding an appropriate amount of water, stirring and kneading, extruding and granulating them with a granulator, and then drying them to obtain the water dispersible granules.

[0017] The suspension is prepared by: adding the insecticide composition containing flupyroxystrobin and oxadiazine, a wetting agent, a dispersant, an antifreeze agent, a preservative, a defoamer and deionized water to a beaker according to the ratio, mixing evenly, transferring to a sand mill, adding zirconium oxide beads to the sand mill, grinding for 2-3 hours, adding a thickener and continuing to grind for 0.5 hours, and making the particle size D 95 The product can be obtained by controlling the particle size below 5 microns and filtering to remove the zirconium oxide beads.

[0018] The dispersant is selected from any one of sodium methylene bisnaphthalene sulfonate, sodium lignin sulfonate, alkylphenol polyoxyethylene ether formaldehyde condensate, sodium naphthalene sulfonate, sodium alkylbenzene sulfonate, naphthalene sulfonate formaldehyde condensate sodium salt, alkylphenol polyoxyethylene ether, polyaryl phenyl ether ammonium phosphate salt, succinic acid diester sulfonic acid sodium salt, and phosphate triethanolamine salt, or a mixture of two or more in any proportion.

[0019] The wetting agent is selected from any one of alkyl polyoxyethylene ether sodium succinate sulfonate, sodium dihydroxybiphenyl sulfonate, phenethylphenol polyoxyethylene ether phosphate, sodium alkyl sulfate, sodium fatty acid ester sulfate, sodium naphthalene sulfonate, sodium dodecyl sulfate, pull-opening powder BX, sodium dodecylbenzene sulfonate, or a mixture of two or more in any proportion.

[0020] The filler is selected from any one of kaolin, clay, corn starch, attapulgite, light calcium carbonate, diatomaceous earth, bentonite, or a mixture of two or more of them in any proportion.

[0021] The disintegrant is selected from any one of sodium chloride, ammonium chloride, ammonium sulfate, sodium carbonate, sodium carboxymethyl starch, and sodium sulfate.

[0022] The binder is selected from any one of methyl cellulose, polyvinyl pyrrolidone, polyvinyl alcohol, polyethylene glycol, and sodium carboxymethyl cellulose.

[0023] The thickener is selected from any one of xanthan gum, sodium alginate, magnesium aluminum silicate, chitosan, guar gum, or a mixture of two or more of the above in any proportion.

[0024] The preservative is selected from any one of potassium sorbate, p-hydroxybenzoic acid, kasone and benzisothiazolinone.

[0025] In the above technical solution, the antifreeze agent is selected from any one of ethylene glycol, propylene glycol, glycerol and urea.

[0026] In the above technical solution, the defoaming agent is selected from any one of dipalmitoyl ethylenediamide, trioctyl phosphate, dimethyl dimethicone, hexadecanol, and glyceryl ricinoleate.

[0027] A use of the composition or preparation in preventing and controlling public health pests.

[0028] When the composition or insecticide is used to control public health pests, it is applied in the form of residual spraying. The wettable powder is diluted 100-200 times with water, the water-dispersible granules are diluted 100-200 times with water, and the suspension is diluted 100-200 times with water and then sprayed on the surfaces of walls, doors, windows, ceilings and homes.

[0029] The public health pests mentioned are mosquitoes, flies, cockroaches and fleas; the application places include hotels, schools, factories, families, farmers, farms and public places.

[0030] The advantages of the technical solution of the present invention are:

[0031] The insecticide of the present invention is processed into a wettable powder, a water-dispersible granule or a suspension by compounding Flupyroxystrobin and Metamizole, thereby reducing the use of organic solvents, being more environmentally friendly, having a significant synergistic effect in preventing and controlling public health pests, reducing the amount of pesticides applied, saving costs, and delaying the development of pest resistance. DETAILED DESCRIPTION

[0032] The present invention is explained below in conjunction with specific embodiments. The specific implementation methods of the technical solution of the present invention are described in detail below, but the present invention is not limited to the following descriptions. The percentages in the following examples refer to weight percentages unless otherwise specified.

[0033] The invention compounds Flupyroxystrobin and mefenamic acid, which can not only improve the control effect on sanitary pests and delay the generation of drug resistance of sanitary pests, but also reduce the harm of organic solvents to the environment, and is more environmentally friendly. The sanitary insecticide composition of the invention has good insecticide effect, has synergistic effect when compounded, and is not easy to generate drug resistance.

[0034] Application Example 1: Determination of the co-toxicity coefficient of flupyroxystrobin and methadone against Culex pipiens pallens Test target: Culex pipiens pallens Test method: Referring to the Guidelines for Indoor Bioassay of Pesticides - Part 1: Contact Activity Test, the spot method NY / T1154.1-2006 was used to conduct an activity determination test on Culex pipiens pallens.

[0035] The median lethal dose LD was calculated by linear weighted regression. 50 , and the co-toxicity coefficient was calculated with reference to Sun Yunpei's method.

[0036] Table 1 Determination of the co-toxicity coefficient of Flupyroxystrobin and Mefenamicin (for Culex pipiens pallens)

[0037]

[0038]

[0039] As shown in Table 1, when the ratio of Flupyroxystrobin to Mefenamicin was 1:10 to 10:1, the co-toxicity coefficient against Culex pipiens pallens was greater than 120, especially when the ratio was 1:5 to 5:1, the co-toxicity coefficient exceeded 130, showing a significant synergistic effect.

[0040] Formulation Example 1: 22% Flupyroxystrobin·Methodoxazolidinone Wettable Powder

[0041] Flupyroxystrobin 2%, mefenamic acid 20%, sodium lignin sulfonate 4%, sodium methylene bisnaphthalene sulfonate 6%, sodium naphthalene sulfonate of alkylphenol polyoxyethylene ether formaldehyde condensate 3%, diatomaceous earth 20%, and kaolin to 100%.

[0042] The formulated materials were mixed evenly, crushed with an ultrafine air flow mill, and then mixed to prepare a 22% Flupyroxystrobin·Methodoxazolidinone wettable powder.

[0043] Formulation Example 2: 27% Flupyroxystrobin·Methodoxazolidinone Wettable Powder

[0044] Flupyroxystrobin 3%, mefenamic acid 24%, alkylphenol polyoxyethylene ether formaldehyde condensate 8%, sodium naphthalenesulfonate 1%, sodium lauryl sulfate 3%, clay 25%, kaolin to 100%.

[0045] The formulated materials were mixed evenly, crushed with an ultrafine air flow mill, and then mixed to prepare a 27% Flupyroxystrobin·Methodoxazolidinone wettable powder.

[0046] Formulation Example 3: 30% Flupyroxystrobin·Methodoxazolidinone Wettable Powder

[0047] Flupyroxystrobin 5%, mefenamic acid 25%, sodium naphthalene sulfonate 2%, sodium alkylbenzene sulfonate 5%, sodium dihydroxybiphenyl sulfonate 5%, corn starch to 100%.

[0048] The formulated materials were mixed evenly, crushed with an ultrafine air flow mill, and then mixed to prepare a 30% Flupyroxystrobin·Methodoxazolidinone wettable powder.

[0049] Formulation Example 4: 5% Flupyroxystrobin·Methodoxazolidinone Wettable Powder

[0050] Flupyroxystrobin 2.5%, mefenamic acid 2.5%, naphthalenesulfonic acid formaldehyde condensate sodium salt 6%, phenethylphenol polyoxyethylene ether phosphate 4%, bentonite 25%, light calcium carbonate to 100%.

[0051] The formulated materials were mixed evenly, crushed with an ultrafine air flow mill, and then mixed to prepare a 5% Flupyroxystrobin·Methodoxazolidinone wettable powder.

[0052] Formulation Example 5: 21% Flupyroxystrobin·Methodoxazolidinone Wettable Powder

[0053] Flupyroxystrobin 17.5%, mefenamic acid 3.5%, alkylphenol polyoxyethylene ether 7%, sodium alkylnaphthalene sulfonate 2%, sodium fatty acid ester sulfate 2%, attapulgite to 100%.

[0054] The formulated materials were mixed evenly, crushed with an ultrafine air flow mill, and then mixed to prepare a 21% Flupyroxystrobin·Methodoxazolidinone wettable powder.

[0055] Formulation Example 6: 18% Flupyroxystrobin·Methodoxazolidinone Wettable Powder

[0056] Flupyroxystrobin 16%, mefenamic acid 2%, polyarylphenyl ether ammonium phosphate 5%, succinic acid diester sodium salt 5%, alkyl polyoxyethylene ether succinic acid ester sodium sulfonate 2%, sodium dodecylbenzene sulfonate 2%, bentonite 10%, kaolin is made up to 100%.

[0057] The formulated materials were mixed evenly, crushed with an ultrafine air flow mill, and then mixed to prepare 18% Flupyroxystrobin·Methodoxazolidinone wettable powder.

[0058] Formulation Example 7: 11% Flupyroxystrobin·Methodoxazolidinone Wettable Powder

[0059] Flupyroxystrobin 10%, mefenamic acid 1%, polyarylphenyl ether ammonium phosphate 5%, succinic acid diester sodium sulfonate 5%, pull open powder BX 2%, sodium dodecylbenzene sulfonate 2%, bentonite 10%, kaolin is made up to 100%.

[0060] The formulated materials were mixed evenly, crushed with an ultrafine air flow mill, and then mixed to prepare 11% Flupyroxystrobin·Methodoxazolidinone wettable powder.

[0061] Formulation Example 8: 44% Flupyroxystrobin·Methodoxazolidinone Water Dispersible Granules

[0062] Flupyroxystrobin 4%, mefenamic acid 40%, sodium lignin sulfonate 6%, naphthalenesulfonic acid formaldehyde condensate sodium salt 4%, sodium lauryl sulfate 5%, sodium chloride 10%, methyl cellulose 0.5%, kaolin to 100%.

[0063] The formula materials are mixed evenly, crushed with an ultrafine air flow mill, kneaded with a small amount of water, and then put into a rotary granulator for granulation and drying to obtain 44% Flupyroxystrobin·Methodoxone water dispersible granules. Formulation Example 9: 45% Flupyroxystrobin·Methodoxone water dispersible granules

[0064] Flupyroxystrobin 5%, mefenamic acid 40%, alkylphenol polyoxyethylene ether formaldehyde condensate 10%, fatty acid ester sodium sulfate 1%, pull open powder BX2%, ammonium chloride 8%, polyvinyl pyrrolidone 1%, clay 10%, corn starch to 100%.

[0065] The formula materials are mixed evenly, crushed with an ultrafine air flow mill, kneaded with a small amount of water, and then put into a rotary granulator for granulation and drying to obtain 45% Flupyroxystrobin·Methodoxone water dispersible granules. Formulation Example 10: 36% Flupyroxystrobin·Methodoxone water dispersible granules

[0066] Flupyroxystrobin 6%, mefenamic acid 30%, sodium lignin sulfonate 9%, sodium alkyl sulfate 4%, ammonium sulfate 9%, polyvinyl alcohol 0.6%, attapulgite to 100%.

[0067] The formulated materials were mixed evenly, crushed with an ultrafine air flow mill, kneaded with a small amount of water, and then put into a rotary granulator for granulation and drying to obtain 36% Flupyroxystrobin·Methodoxone water dispersible granules. Formulation Example 11: 10% Flupyroxystrobin·Methodoxone water dispersible granules

[0068] Flupyroxystrobin 5%, mefenamic acid 5%, sodium methylenebisnaphthalene sulfonate 5%, sodium alkylbenzene sulfonate 3%, sodium dodecylbenzene sulfonate 1%, sodium lauryl sulfate 2%, sodium carbonate 10%, polyethylene glycol 0.1%, diatomaceous earth made up to 100%.

[0069] The formulated materials are mixed evenly, crushed with an ultrafine air flow mill, kneaded with a small amount of water, and then put into a rotary granulator for granulation and drying to obtain 10% Flupyroxystrobin·Methodoxone water dispersible granules. Formulation Example 12: 50% Flupyroxystrobin·Methodoxone water dispersible granules

[0070] Flupyroxystrobin 42%, mefenamic acid 8%, alkylphenol polyoxyethylene ether formaldehyde condensate 1%, sodium methylene bisnaphthalene sulfonate 6%, sodium alkyl naphthalene sulfonate 5%, sodium carboxymethyl starch 6%, carboxymethyl cellulose 0.5%, corn starch 20%, and attapulgite to 100%.

[0071] The formula materials are mixed evenly, crushed with an ultrafine air flow mill, kneaded with a small amount of water, and then put into a rotary granulator for granulation and drying to obtain 50% Flupyroxystrobin·Methodoxone water dispersible granules. Formulation Example 13: 18% Flupyroxystrobin·Methodoxone water dispersible granules

[0072] Flupyroxystrobin 16%, mefenamic acid 2%, sodium succinate sulfonate 5%, sodium methylene bisnaphthalene sulfonate 4%, BX 5%, sodium sulfate 10%, polyvinyl alcohol 0.2%, kaolin to 100%. The formula materials are mixed evenly, crushed with an ultra-fine air flow mill, kneaded with a small amount of water, and then put into a rotary granulator for granulation and drying to obtain 18% Flupyroxystrobin·mefenamic acid water dispersible granules. Formulation Example 14: 11% Flupyroxystrobin·mefenamic acid water dispersible granules

[0073] Flupyroxystrobin 10%, mefenamic acid 1%, sodium lignin sulfonate 10%, sodium lauryl sulfate 4%, sodium sulfate 5%, sodium carboxymethyl cellulose 0.3%, corn starch to 100%.

[0074] The formulated materials were mixed evenly, crushed with an ultrafine air flow mill, kneaded with a small amount of water, and then put into a rotary granulator for granulation and drying to obtain 11% Flupyroxystrobin·Methodoxone water dispersible granules. Formulation Example 15: 11% Flupyroxystrobin·Methodoxone suspension

[0075] Flupyroxystrobin 1%, mefenamic acid 10%, phosphate triethanolamine salt 3%, sodium methylenebisnaphthalene sulfonate 5%, sodium dihydroxybiphenyl sulfonate 2%, sodium naphthalene sulfonate 1%, xanthan gum 0.2%, magnesium aluminum silicate 0.8%, potassium sorbate 0.5%, ethylene glycol 10%, hexadecanol 0.3%, deionized water to 100%. The formula materials are mixed evenly and sand-milled by a sand mill until the particle size is less than 5 microns to obtain 11% Flupyroxystrobin·mefenamic acid suspension.

[0076] Formulation Example 16: 13.5% Flupyroxystrobin·Methodoxazolidinone Suspension

[0077] Flupyroxystrobin 1.5%, mefenamic acid 12%, succinic acid diester sulfonic acid sodium salt 10%, alkylphenol polyoxyethylene ether formaldehyde condensate sodium naphthalene sulfonate 5%, xanthan gum 0.2%, sodium alginate 0.5%, parahydroxybenzoic acid 1%, propylene glycol 5%, dimethicone 0.1%, deionized water to 100%.

[0078] The formulated materials were mixed uniformly and sand-milled until the particle size was less than 5 microns to obtain a 13.5% Flupyroxystrobin·Methodoxazolidinone suspension.

[0079] Formulation Example 17: 30% Flupyroxystrobin·Methodoxazolidinone Suspension

[0080] Flupyroxystrobin 5%, mefenamic acid 25%, polyarylphenyl ether ammonium phosphate 1%, sodium methylenebisnaphthalene sulfonate 5%, sodium dihydroxybiphenyl sulfonate 2%, sodium dodecylbenzene sulfonate 3%, chitin 0.1%, kason 0.3%, glycerol 5%, dipalmitoylethylenediamine 0.5%, deionized water to 100%. The formula materials are mixed evenly and sand-milled with a sand mill until the particle size is less than 5 microns to obtain a 30% Flupyroxystrobin mefenamic acid suspension.

[0081] Formulation Example 18: 5% Flupyroxystrobin·Methodoxazolidinone Suspension

[0082] Flupyroxystrobin 2.5%, oxadiazine 2.5%, alkylphenol polyoxyethylene ether 5%, sodium lignin sulfonate 3%, phenylethylphenol polyoxyethylene ether phosphate 3%, guar gum 0.3%, magnesium aluminum silicate 0.7%, benzisothiazolinone 0.1%, urea 3%, glyceryl ricinoleate 0.5%, deionized water is added to 100%. The formula materials are mixed evenly and sand-milled with a sand mill until the particle size is less than 5 microns to obtain a 5% Flupyroxystrobin oxadiazine suspension.

[0083] Formulation Example 19: 9% Flupyroxystrobin·Methodoxazolidinone Suspension

[0084] Flupyroxystrobin 7.5%, mefenamic acid 1.5%, sodium lignin sulfonate 10%, sodium alkyl naphthalene sulfonate 4%, sodium naphthalene sulfonate 1%, xanthan gum 0.3%, potassium sorbate 0.5%, propylene glycol 8%, dimethicone 0.3%, deionized water to 100%.

[0085] The formulated materials were mixed uniformly and sand-milled until the particle size was less than 5 microns to obtain a 9% Flupyroxystrobin·Methodoxazolidinone suspension.

[0086] Formulation Example 20: 27% Flupyroxystrobin·Methodoxazolidinone Suspension

[0087] Flupyroxystrobin 24%, mefenamic acid 3%, naphthalenesulfonic acid formaldehyde condensate sodium salt 8%, phenethylphenol polyoxyethylene ether phosphate 3%, sodium alginate 0.1%, magnesium aluminum silicate 0.5%, kason 0.1%, ethylene glycol 3%, trioctyl phosphate 0.5%, deionized water to 100%.

[0088] The formulated materials were mixed uniformly and sand-milled until the particle size was less than 5 microns to obtain a 27% Flupyroxystrobin·Methodoxazolidinone suspension.

[0089] Formulation Example 21: 5.5% Flupyroxystrobin·Methodoxazolidinone Suspension

[0090] Flupyroxystrobin 5%, oxadiazine 0.5%, sodium alkylbenzene sulfonate 2%, triethanolamine phosphate 6%, sodium naphthalene sulfonate 5%, xanthan gum 0.3%, benzisothiazolinone 0.2%, urea 4%, dimethicone 0.1%, deionized water to 100%.

[0091] The formulated materials were mixed uniformly and sand-milled until the particle size was less than 5 microns to obtain a 5.5% Flupyroxystrobin·Methodoxazolidinone suspension.

[0092] Application Example 2: Indoor Retention Efficacy Test for Controlling Mosquitoes and Flies Test Target: Culex pipiens pallens, female adults that have not sucked blood on the 3rd to 5th day after emergence;

[0093] Houseflies, adults on the 3rd to 4th day after emergence, half female and half male;

[0094] Test method: Refer to GB / T 13917.1-2009, residual spray test;

[0095] Test treatment: The total concentration of active ingredients in formulation examples 1, 5, 8, 12, 15, and 19 was diluted to 500 mg / L; Control sample 1: 10% Flupyroxystrobin wettable powder was diluted to 500 mg / L;

[0096] Control sample 2: 10% methadone wettable powder diluted to 500 mg / L;

[0097] Test results:

[0098] Table 2 Efficacy test of formulation examples 1, 5, 8, 12, 15, 19 against mosquitoes and flies

[0099]

[0100] As can be seen from Table 2, the knockdown effects of formulation examples 1, 5, 8, 12, 15, and 19 on Culex pipiens pallens and houseflies were better than those of the single-dose samples of the control sample, and the mortality rates were also better than those of the single-dose samples of the control sample. It can be seen that the combination of Flupyroxystrobin and methadone has a good control effect on Culex pipiens pallens and houseflies by residual spraying.

[0101] Application Example 3: Indoor Retention Efficacy Test for Controlling Cockroaches Test Target: German cockroaches, 10-15-day-old adults, half female and half male;

[0102] Test method: Refer to GB / T 13917.1-2009, residual spray test;

[0103] Test treatment: The total concentration of active ingredients in formulation examples 2, 6, 9, 13, 18, and 20 was diluted to 500 mg / L; Control sample 1: 10% Flupyroxystrobin wettable powder was diluted to 500 mg / L;

[0104] Control sample 2: 10% methadone wettable powder diluted to 500 mg / L;

[0105] Test results:

[0106] Table 3 Efficacy test of formulation examples 2, 6, 9, 13, 18, 20 against German cockroach

[0107] Processing Name 0.5h knockdown rate 1h knockdown rate 2h knockdown rate 72h mortality rate Formulation Example 2 53.3％ 80％ 100％ 100％ Preparation Example 6 50％ 76.7％ 100％ 100％ Preparation Example 9 46.7％ 80％ 100％ 100％ Formulation Example 13 50％ 80％ 100％ 100％ Preparation Example 18 46.7％ 83.3％ 100％ 100％ Preparation Example 20 43.3％ 86.7％ 100％ 100％ Control sample 1 13.3％ 33.7％ 80％ 80％ Control sample 2 23.3％ 46.7％ 86.7％ 86.7％

[0108] As shown in Table 3, the formulation examples 2, 6, 9, 13, 18, and 20 had a significant knockdown effect on German cockroaches at 0.5 h, which was much better than the control samples 1 and 2, and the knockdown rate of German cockroaches at 2 h reached 100%, which was also better than the control samples 1 and 2; the 72 h lethality of the formulation examples 2, 6, 9, 13, 18, and 20 against German cockroaches was better than the control single-dose sample. It can be seen that the combination of Flupyroxystrobin and methadone has a good control effect on German cockroaches by residual spraying.

[0109] Application Example 4: Test on the efficacy of indoor retention of fleas

[0110] Test target: Xenopus chelicerae, 3-day-old to 10-day-old adults, half female and half male;

[0111] Test method: Refer to GB / T 13917.1-2009, residual spray test;

[0112] Test treatment: The total concentration of active ingredients in formulation examples 3, 7, 10, 14, 19, and 21 was diluted to 500 mg / L; Control sample 1: 10% Flupyroxystrobin wettable powder was diluted to 500 mg / L;

[0113] Control sample 2: 10% methadone wettable powder diluted to 500 mg / L;

[0114] Test results:

[0115] Table 4 Efficacy test of formulation examples 3, 7, 10, 14, 19, 21 against Xenopus chelicerae

[0116] Processing Name 0.5h knockdown rate 1h knockdown rate 24h mortality rate Formulation Example 3 78％ 100％ 100％ Formulation Example 7 80％ 100％ 100％ Preparation Example 10 76％ 100％ 100％ Formulation Example 14 74％ 100％ 100％ Formulation Example 19 78％ 100％ 100％ Preparation Example 21 76％ 100％ 100％ Control sample 1 36％ 74％ 70％ Control sample 2 40％ 82％ 80％

[0117] As shown in Table 4, formulation examples 3, 7, 10, 14, 19, and 21 had significant knockdown effects on Xenopsydae cheopis within 0.5 h, which was much better than that of control samples 1 and 2. The knockdown rates of formulation examples 3, 7, 10, 14, 19, and 21 on Xenopsydae cheopis within 1 h all reached 100%, which was better than that of control samples 1 and 2. The 24 h lethality rates of formulation examples 3, 7, 10, 14, 19, and 21 on Xenopsydae cheopis were better than those of control samples 1 and 2. It can be seen that the combination of Flupyroxystrobin and Mefenamicin has a good control effect on Xenopsydae cheopis by residual spraying.

[0118] Application Example 5: Retention efficacy test on three different absorption contact surfaces Test target: Culex pipiens pallens, female adults that have not sucked blood on the 3rd to 5th day after emergence;

[0119] Houseflies, adults on the 3rd to 4th day after emergence, half female and half male;

[0120] German cockroach, 10-15-day-old adults, half female and half male;

[0121] Xenopus chelicerae, 3-day-old to 10-day-old adults, half female and half male;

[0122] Test method: Refer to GB / T 13917.1-2009, residual spray test, test once every 15 days, and evaluate based on the duration (d) of 24h (72h for cockroaches) mortality rate greater than 70%.

[0123] Test equipment panel: non-absorbent surface - glass surface, rated as A for duration ≥ 90 days, rated as B for duration ≥ 60 days;

[0124] Semi-absorption surface - varnish surface, the duration ≥ 60d is rated as Class A, the duration ≥ 45d is rated as Class B;

[0125] Absorption surface: white lime surface (mosquitoes, flies, fleas), cement surface (cockroaches), duration ≥ 45 days is rated as Class A, duration ≥ 30 days is rated as Class B;

[0126] Experimental treatment: The total concentration of active ingredients in formulation examples 4, 11, and 18 was diluted to 500 mg / L;

[0127] Control sample 1: 10% Flupyroxystrobin wettable powder diluted to 500 mg / L;

[0128] Control sample 2: 10% methadone wettable powder diluted to 500 mg / L;

[0129] Test results:

[0130] Table 5 Retention efficacy test of formulation examples 4, 11, and 18 on non-absorbent surface (glass surface)

[0131]

[0132] Table 6 Retention efficacy test of semi-absorbent surface (varnish surface) of formulation examples 4, 11, and 18

[0133]

[0134]

[0135] Table 7 Retention efficacy test of formulation examples 4, 11, 18 on absorption surface (lime surface / cement surface)

[0136]

[0137]

[0138] The test results in the table above show that in the three different absorption contact surface tests, the duration ratings of the preparation examples 4, 11 and 18 of the present invention on Culex pipiens pallens, housefly, German cockroach and Xenopus cheopis were all graded A, while the duration of some targets in the control group was graded B. The comprehensive control effect of the present invention on different targets on three different absorption contact surfaces was better than that of the control group, and the retention effect was better than that of the control group.

[0139] Application Example 6: Outdoor efficacy comparison test for controlling flies

[0140] Test target: Flies Test method: Select the walls and ground of the farm building as the test objects and divide them into different areas. Spray the agent on the walls and ground surfaces, and record the fly density reduction rate of each treatment group after 1, 2, and 3 days.

[0141] Test treatment: Preparation examples 2, 9, and 16 were diluted 100 times, with a dosage of 20 mg active ingredient / m 2 ;

[0142] Control sample 3: 10% cyhalothrin wettable powder on the market was diluted 100 times, and the dosage was 20 mg active ingredient / m 2 ;

[0143] Control sample 4: Commercially available 6% highly effective cypermethrin + 4% propoxur suspension diluted 100 times, dosage 20 mg active ingredient / m 2 ;

[0144] Test results:

[0145] Table 8 Comparative test of the efficacy of formulation examples 2, 9, and 16 against flies outdoors

[0146]

[0147]

[0148] The results show that the examples 2, 9 and 16 of the present invention have obvious fly control effects, with a 1-day density reduction rate of more than 50% and a 3-day density reduction rate of more than 95%, which are better than the control samples 3 and 4. It can be seen that the residual spraying method of Flupyroxystrobin and Mefenamicin has a good control effect.

[0149] The above examples are only for illustrating the technical concept and technical features of the present invention, and cannot be used to limit the protection scope of the present invention. Any equivalent transformation or modification made according to the essence of the present invention should be included in the protection scope of the present invention.

Claims

1. An insecticidal composition, characterized in that: The composition is a methoxyacrylate compound represented by formula I and oxadiazine, wherein the weight ratio of the methoxyacrylate compound to oxadiazine is 1:10 to 10:1; Formula I is 2. The insecticidal composition according to claim 1, characterized in that The weight ratio of the methoxyacrylate compound to methicillin is 1:5 to 5:

1.

3. An insecticide, characterized in that: The insecticide uses the composition described in claim 1 as active ingredients and auxiliary materials; wherein the active ingredients account for 10% to 50% of the preparation mass.

4. The insecticide according to claim 3, characterized in that: The pesticide formulation is a wettable powder, a water dispersible granule or a suspension.

5. The insecticide according to claim 3 or 4, characterized in that: The wettable powder comprises 5% to 30% of an insecticide composition containing Flupyroxystrobin and oxadone, 1% to 10% of a dispersant, 1% to 5% of a wetting agent, and the filler is supplemented to 100%.

6. The insecticide according to claim 3 or 4, characterized in that: The water dispersible granules are composed of 10% to 50% of a compound insecticide composition containing flupyroxystrobin and mefenamic acid, 1% to 10% of a dispersant, 1% to 5% of a wetting agent, 1% to 10% of a disintegrant, 0.1% to 1% of a binder, and the filler is supplemented to 100%.

7. The insecticide according to claim 3 or 4, characterized in that: The suspension comprises, by weight, 5% to 30% of a compound insecticide composition containing flupyroxystrobin and mefenamic acid, 1% to 10% of a dispersant, 1% to 5% of a wetting agent, 0.1% to 1% of a thickener, 0.1% to 1% of a preservative, 3% to 10% of an antifreeze agent, 0.1% to 0.5% of a defoaming agent, and deionized water is added to make up to 100%.

8. The use according to claim 1 or 3, characterized in that: Application of the composition or preparation in preventing and controlling public health pests.

9. The use according to claim 8, characterized in that: When the composition or insecticide is used to control public health pests, it is applied in the form of residual spraying. The wettable powder is diluted 100-200 times with water, the water-dispersible granules are diluted 100-200 times with water, and the suspension is diluted 100-200 times with water and then sprayed on the surfaces of walls, doors, windows, ceilings and homes.

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