Medical support system

Abstract

The invention provides a medical stent system which comprises a covered stent and a coagulation accelerating piece arranged on the peripheral face of the covered stent, and the coagulation accelerating piece comprises a plurality of coagulation accelerating fibers and is used for filling a tumor cavity to slow down the flow speed of blood entering the tumor cavity and promote blood clotting in the tumor cavity. Therefore, generation of II-type inner leakage can be reduced or even avoided, and continuous expansion of a tumor cavity is avoided.

Description

Technical Field

[0001] The present invention belongs to the technical field of medical devices, and in particular relates to a medical stent system. Background Art

[0002] In recent years, endovascular abdominal aortic aneurysm repair (EVAR) has gradually become the first choice for interventional doctors to treat abdominal aortic aneurysms. As a minimally invasive surgical procedure, EVAR causes a smaller surgical incision, allowing many high-risk patients who cannot tolerate open-chest surgery to have the opportunity to undergo surgery.

[0003] However, long-term clinical data studies have shown that the efficacy of EVAR surgery has not met expectations. Studies have shown that within 6 months after surgery, the survival rate of EVAR patients is higher than that of open-chest surgery patients, but over time, the survival advantage of EVAR patients gradually disappears. In addition, 8 years after surgery, the overall survival rate of EVAR patients is lower than that of patients undergoing open-chest surgery. The possible reason for this result is that EVAR surgery causes secondary aortic aneurysm rupture. Endoleaks are prone to occur after EVAR surgery. According to statistics, the total incidence of various types of endoleaks after EVAR surgery is 20% to 50%, among which the incidence of type II endoleaks is as high as 10% to 25%. The occurrence of type II endoleaks will lead to continuous expansion of the aneurysm cavity, which will then cause rupture. Summary of the invention

[0004] The object of the present invention is to provide a medical stent system, which is intended to fill the tumor cavity to slow down the flow rate of blood entering the tumor cavity, promote blood clotting in the tumor cavity, and avoid II endoleak.

[0005] To achieve the above-mentioned objectives, the present invention provides a medical stent system, comprising a coated stent and a coagulant arranged on the outer peripheral surface of the coated stent, wherein the coagulant comprises a plurality of coagulant fibers for filling the tumor cavity to slow down the flow rate of blood entering the tumor cavity and promote blood clotting in the tumor cavity.

[0006] Optionally, the coagulation promoter further comprises a self-expanding shaping portion, the coagulation promoter fiber is attached to the shaping portion, one end of the shaping portion is connected to the coated stent, and the other end is a free end; the shaping portion is at least partially pre-shaped into a three-dimensional structure.

[0007] Optionally, all the coagulation promoters are divided into a number of coagulation promoter components, each of which includes a plurality of the coagulation promoters; all the coagulation promoter components are arranged at intervals along the circumference of the coated stent; all the coagulation promoters of the same coagulation promoter component are arranged at intervals along the axial direction of the coated stent and are arranged spirally around the axis of the coated stent.

[0008] Optionally, the coated stent includes a first sub-stent and two second sub-stents, the two second sub-stents are connected in parallel to the same axial end of the first sub-stent and are respectively connected to the first sub-stent; some segments of the second sub-stent are embolic segments; the coagulation promoter is provided on the outer peripheral surface of the first sub-stent and the outer peripheral surface of each of the embolic segments.

[0009] Optionally, all the coagulants arranged on the first sub-support are divided into a number of first coagulant assemblies, which include a plurality of coagulants; all the first coagulant assemblies are arranged at intervals along the circumference of the first sub-support; all the coagulants of the same first coagulant assembly are arranged at intervals along the axial direction of the first sub-support and are arranged spirally around the axis of the first sub-support; and / or, all the coagulants on each embolization segment are divided into a number of second coagulant assemblies, which include a plurality of coagulants; all the second coagulant assemblies located on the same embolization segment are arranged at intervals along the circumference of the corresponding second sub-support; all the coagulants of the same second coagulant assembly are arranged at intervals along the axial direction of the corresponding second sub-support and are arranged spirally around the axis of the corresponding second sub-support.

[0010] Optionally, the first sub-stent comprises a plurality of stent rings spaced apart along its axial direction, and 1 to 3 stent rings are spaced apart between two adjacent stent members of the same first stent assembly; and / or,

[0011] Each of the second sub-supports comprises a plurality of support rings spaced apart along the axial direction thereof, and there are 1 to 3 support rings spaced apart between two adjacent coagulation promoting members of the same second coagulation promoting component.

[0012] Optionally, the coagulation promoter disposed on the outer circumference of the first sub-support is inclined relative to the axis of the first sub-support; and / or the coagulation promoter disposed on the outer circumference of the embolization segment is inclined relative to the corresponding axis of the second sub-support.

[0013] Optionally, the first sub-bracket includes a first segment and a second segment that are axially connected, and one end of the second segment away from the first segment is connected to two of the second sub-brackets;

[0014] The length of the coagulation-promoting fiber of the coagulation-promoting member arranged on the first segment is 5 mm to 50 mm, and the length of the coagulation-promoting fiber of the coagulation-promoting member arranged on the second segment is 50 mm to 110 mm;

[0015] The length of the coagulation-promoting fiber of the coagulation-promoting member arranged on the second sub-bracket is 5 mm to 50 mm; and / or,

[0016] The number of the coagulation-promoting fibers of each of the coagulation-promoting elements arranged on the first segment is smaller than the number of the coagulation-promoting fibers of each of the coagulation-promoting elements arranged on the second segment; the number of the coagulation-promoting fibers of each of the coagulation-promoting elements arranged on the second segment is larger than the number of the coagulation-promoting fibers of each of the coagulation-promoting elements arranged on the second sub-bracket.

[0017] Optionally, the coated stent includes a first sub-stent and two second sub-stents, the two second sub-stents are connected in parallel to the same axial end of the first sub-stent and are respectively connected to the first sub-stent; the first sub-stent includes an axially connected first segment and a second segment, the second segment is connected to the two second sub-stents at one end away from the first segment; some segments of the second sub-stent are embolization segments; the coagulation promoter is provided on the outer peripheral surface of the first sub-stent and the outer peripheral surface of each of the embolization segments;

[0018] The axial length of the shaping portion of the coagulation promoter arranged on the first segment is 5mm to 20mm, and the axial length of the shaping portion of the coagulation promoter arranged on the second segment is 15mm to 50mm; and / or the axial length of the shaping portion arranged on the embolization segment is 5mm to 20mm.

[0019] Optionally, a coagulation-promoting coating is provided on at least part of the outer surface of the coagulation-promoting member.

[0020] Compared with the prior art, the medical stent system of the present invention has the following advantages:

[0021] The aforementioned medical stent system comprises a stent graft and a coagulant member disposed on the outer peripheral surface of the stent graft, wherein the coagulant member comprises a plurality of coagulant fibers, which are used to fill the tumor cavity to slow down the flow rate of blood entering the tumor cavity and promote blood clotting in the tumor cavity. Thus, the generation of type II endoleak can be reduced, thereby avoiding the continuous expansion of the tumor cavity.

[0022] Furthermore, the coagulation promoting member also includes a self-expanding shaping portion, the coagulation promoting fibers are attached to the shaping portion, the shaping portion is connected to the stent graft, and the shaping portion is at least partially pre-shaped into a three-dimensional structure. When the medical stent system is implanted in a blood vessel and is at least partially located in the aneurysm cavity of an aortic aneurysm, the shaping portion naturally expands to a predetermined shape, and the coagulation promoting fibers thereon stretch accordingly. Under the support of the shaping portion, the coagulation promoting fibers will not be impacted by the blood flow and collapse to the outer peripheral surface attached to the stent graft, so that the coagulation promoting fibers can effectively fill the aneurysm cavity, thereby effectively slowing down the flow rate of blood entering the aneurysm cavity, promoting blood clotting, and then blocking the blood flow in the aneurysm cavity, so that the pressure in the aneurysm cavity is reduced, thereby avoiding the occurrence of type II endoleak.

[0023] Furthermore, all the coagulation promoters are divided into a plurality of coagulation promoter components, and the coagulation promoter components include a plurality of the coagulation promoters; all the coagulation promoter components are arranged at intervals along the circumference of the coated stent; all the coagulation promoters of the same coagulation promoter component are arranged at intervals along the axial direction of the coated stent and spirally arranged around the axis of the coated stent; or, the coated stent includes a first sub-stent and a second sub-stent, and some segments of the second sub-stent are embolic segments; the coagulation promoters are provided on the embolic segments of the first sub-stent and the second sub-stent; all the coagulation promoters provided on the first sub-stent are divided into a plurality of first coagulation promoter components, and all the first coagulation promoter components are arranged in the The first sub-stent is arranged at intervals in the circumferential direction, each of the first coagulation promoting components includes a plurality of coagulation promoting elements, and all the coagulation promoting elements of the same first coagulation promoting component are arranged at intervals in the axial direction of the first sub-stent and arranged spirally around the axis of the first sub-stent; the coagulation promoting elements arranged on the embolization segment are divided into a plurality of second coagulation promoting elements, and all the second coagulation promoting elements on the same embolization segment are arranged at intervals in the circumferential direction of the corresponding second sub-stent, and each of the second coagulation promoting components includes a plurality of coagulation promoting elements, and all the coagulation promoting elements of the same second coagulation promoting component are arranged at intervals in the axial direction of the corresponding second sub-stent and arranged spirally around the axis of the corresponding second sub-stent. The arrangement of the coagulation promoting elements can effectively reduce the overlap between the different coagulation promoting elements, avoid the tangling of the coagulation promoting elements, and make them fill the tumor cavity to slow down the flow rate of the blood entering the tumor cavity, promote blood clotting in the tumor cavity, and avoid II internal leakage; at the same time, it can effectively reduce the resistance encountered by the medical stent system when it is pressed to the delivery system during the production process and when it is released in the vascular cavity, thereby increasing the production stability and safety during surgical treatment. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] The accompanying drawings are used to better understand the present invention and do not constitute an improper limitation of the present invention.

[0025] Figure 1 1 is a schematic structural diagram of a medical stent system provided according to an embodiment of the present invention, wherein a first sub-stent and two second sub-stents are shown in the figure, but the second sub-stents in the figure are incomplete;

[0026] Figure 2 A schematic diagram showing an abdominal aortic aneurysm;

[0027] Figure 3 A schematic diagram showing a medical stent system provided by an embodiment of the present invention when applied to the treatment of abdominal aortic aneurysm;

[0028] Figure 4 is a schematic structural diagram of a medical stent system provided according to an embodiment of the present invention, Figure 4 and Figure 1 The difference lies in the different structures of the coagulants;

[0029] Figure 5 yes Figure 4 A schematic diagram of the structure of a coagulation-promoting component of the provided medical stent system;

[0030] Figure 6 yes Figure 4 A schematic structural diagram of a shaping portion of a coagulation-promoting component of a provided medical stent system;

[0031] Figure 7 yes Figure 4 A schematic diagram of the provided medical stent system when used in the treatment of abdominal aortic aneurysm.

[0032] [Description of reference numerals is as follows]:

[0033] 110-first sub-stent, 111-first segment, 112-second segment, 120-second sub-stent, 121-embolization segment, 200-coagulation promoter, 210-coagulation promoter fiber, 220-shaping portion, 221-three-dimensional spiral structure, 300-anchoring mechanism, 101-stent ring, 102-membrane, 10-aortic aneurysm, 21-blood inflow tract, 22-blood outflow tract, 23-abdominal aorta, 24-left iliac artery, 25-right iliac artery. DETAILED DESCRIPTION

[0034] The following is an explanation of the embodiments of the present invention by specific examples, and those skilled in the art can easily understand other advantages and effects of the present invention from the contents disclosed in this specification. The present invention can also be implemented or applied through other different specific embodiments, and the details in this specification can also be modified or changed in various ways based on different viewpoints and applications without departing from the spirit of the present invention. It should be noted that the illustrations provided in the present embodiment only illustrate the basic concept of the present invention in a schematic manner, and only the components related to the present invention are shown in the figure instead of being drawn according to the number, shape and size of the components in the actual implementation. The type, quantity and proportion of each component in the actual implementation can be a random change, and the component layout type may also be more complicated.

[0035] In addition, each embodiment of the following description has one or more technical features, but this does not mean that the user of the present invention must implement all the technical features in any embodiment at the same time, or can only implement part or all of the technical features in different embodiments separately. In other words, under the premise that implementation is possible, those skilled in the art can selectively implement part or all of the technical features in any embodiment according to the disclosure of the present invention and according to the design specifications or implementation requirements, or selectively implement a combination of part or all of the technical features in multiple embodiments, thereby increasing the flexibility of the implementation of the present invention.

[0036] As used in this specification, the singular forms "one", "an", and "the" include plural objects, and the plural form "a plurality" includes more than two objects, unless the content clearly indicates otherwise. As used in this specification, the term "or" is generally used in a sense that includes "and / or", unless the content clearly indicates otherwise, and the terms "installed", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection. It can be a mechanical connection or an electrical connection. It can be directly connected or indirectly connected through an intermediate medium, and it can be a connection between two elements or an interactive relationship between two elements. Relational terms such as the terms "first", "second", etc. are only used to distinguish one entity or operation from another entity or operation, and do not necessarily require or imply any such actual relationship or order between these entities or operations, nor do they indicate or imply relative importance or implicitly indicate the number of technical features indicated. It should be understood that the terms "center", "longitudinal", "lateral", "length", "width", "thickness", "up", "down", "front", "back", "left", "right", "vertical", "horizontal", "top", "bottom", "inside", "outside", "axial", "radial", "circumferential" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, rather than indicating or implying that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore cannot be understood as limiting the present invention. For those of ordinary skill in the art, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0037] The purpose of the present invention is to provide a medical stent system which can be used for interventional treatment of aortic aneurysms. The medical stent system avoids the occurrence of type II endoleak by promoting embolization of the aneurysm cavity, thereby avoiding the problem of continuous expansion or even rupture of the aneurysm cavity caused by type II endoleak.

[0038] In order to make the purpose, advantages and features of the present invention more clear, the present invention is further described in detail below in conjunction with specific embodiments and drawings. It should be noted that the drawings are all in a very simplified form and are not in precise proportions, and are only used to conveniently and clearly assist in explaining the purpose of the embodiments of the present invention. The same or similar reference numerals in the drawings represent the same or similar components.

[0039] Please refer to Figure 1 , Figures 4 to 6The medical stent system provided in the embodiment of the present invention comprises a stent graft and a coagulation promoting member 200 disposed on the outer peripheral surface of the stent graft, wherein the coagulation promoting member 200 comprises a plurality of coagulation promoting fibers 210. The medical stent system is used to treat Figure 2 The aortic aneurysm 10 shown in the figure has an aneurysm cavity connected to a plurality of side branch vessels, a portion of which forms a blood inflow channel 21, and another portion of which forms a blood outflow channel 22. When the medical stent system is used, Figure 3 and Figure 7 As shown, the stent graft is at least partially used to be arranged in the aneurysm cavity of the aortic aneurysm 10, so that the coagulation promoting member 200 is located between the aneurysm wall and the outer peripheral surface of the stent graft, and the coagulation promoting fibers 210 of the coagulation promoting member 200 are used to slow down the flow rate of blood flowing into the aneurysm cavity from the blood inflow channel 21, which can promote blood coagulation to form blood clots. The blood clots form a space-occupying effect in the aneurysm cavity until the blood clots completely fill the aneurysm cavity, blocking the blood flow in the aneurysm cavity, reducing or even avoiding the occurrence of type II endoleak, and thus avoiding the continuous expansion of the aortic aneurysm. Preferably, the coagulation promoting fibers 210 are cilia that can promote blood clotting.

[0040] It should be understood that the medical stent system further includes an anchoring mechanism 300 , which is connected to one end of the stent graft. The medical stent system is anchored in the blood vessel through the anchoring mechanism 300 .

[0041] When there are branch arteries near the aortic aneurysm 10, for example, please continue to refer to Figure 2 , the aortic aneurysm 10 is located in the abdominal aorta 23, and is close to the intersection of the abdominal aorta 23 with the left iliac artery 24 and the right iliac artery 25. Based on this, it is preferred that the medical stent system includes a first sub-stent 110 and two second sub-stents 120. The two second sub-stents 120 are connected in parallel at the same axial end of the first sub-stent 110. Specifically, the anchoring mechanism 300 is provided on one end of the first sub-stent 110, and the two second sub-stents 120 are connected to the end of the first sub-stent 110 away from the anchoring mechanism 300. The two second sub-stents 120 are also respectively connected to the first sub-stent 110. When in use, one second sub-stent 120 at least partially extends into the left iliac artery 24, and the other second sub-stent 120 at least partially extends into the right iliac artery 25.

[0042] When each of the second sub-stents 120 is partially located in the aortic aneurysm 10, the portion of each of the second sub-stents 120 located in the aortic aneurysm 10 is called an embolization segment 121, and thus, the embolization segment 121 is connected to the first sub-stent 110. Based on this, the outer circumference of the first sub-stent 110 and the outer circumference of each of the embolization segments 121 are provided with the coagulation promoting member 200.

[0043] Herein, all the coagulation promoting members 200 disposed on the first sub-support 110 are divided into a plurality of first coagulation promoting members (not labeled in the figure), and all the coagulation promoting members 200 disposed on each of the embolization segments 121 are divided into a plurality of second coagulation promoting members (not labeled in the figure). In other words, a plurality of the first coagulation promoting members are disposed on the first sub-support 110, and a plurality of the second coagulation promoting members are disposed on each of the embolization segments 121. Each of the first coagulation promoting members includes a plurality of the coagulation promoting members 200, and each of the second coagulation promoting members also includes a plurality of the coagulation promoting members 200.

[0044] It is understandable that if there is no branch artery near the aortic aneurysm, the stent graft only includes the first sub-stent but not the second sub-stent (not shown in the figure). That is, the stent graft is a straight-tube stent.

[0045] Next, the optional configuration of the medical stent system is described by taking the medical stent including the first sub-stent 110, the second sub-stent 120, the first coagulation promoting component and the second coagulation promoting component as an example.

[0046] Optionally, when there are multiple first coagulation-promoting components, all the first coagulation-promoting components are arranged at intervals along the circumference of the first sub-support 110. All the coagulation-promoting members 200 of the same first coagulation-promoting component are arranged at intervals along the axial direction of the first sub-support 110 and are arranged spirally around the axis of the first sub-support 110. Similarly, at least one second coagulation-promoting component is provided on each of the embolization segments 121. When multiple second coagulation-promoting components are provided on each of the embolization segments 121, all the second coagulation-promoting components on the same embolization segment 121 are arranged at intervals along the circumference of the corresponding second sub-support 120. All the coagulation-promoting members 200 of the same second coagulation-promoting component are arranged at intervals along the axial direction of the corresponding second sub-support 120 and are arranged spirally around the axis of the corresponding second sub-support 120.

[0047] The arrangement of the first coagulant component on the first sub-stent 110 and the arrangement of the second coagulant component on the corresponding second sub-stent 120 reduce the overlap between different coagulant elements 200, thereby avoiding knotting of the coagulant elements, allowing them to fill the tumor cavity to slow down the flow rate of blood entering the tumor cavity, promote blood clotting in the tumor cavity, and avoid II internal leakage; at the same time, it can reduce the radial dimension of the medical stent system when it is compressed and gripped, thereby reducing the resistance from the delivery system when the medical stent system is compressed and gripped to the delivery system during production and released into the blood vessel during use, thereby improving production stability and safety during surgery.

[0048] The first sub-stent 110 and the second sub-stent 120 have substantially the same configuration. Specifically, each stent graft (including the first sub-stent 110 and the second sub-stent 120) includes a plurality of stent rings 101 and a coating 102. In the corresponding stent graft (the first sub-stent 110 or any one of the second sub-stents 120), a plurality of stent rings 101 are arranged at intervals along the axial direction thereof, and the coating 102 connects all the stent rings 101. In some embodiments, the coating 102 includes at least an outer coating, which is sutured on the outer circumferential surface of the corresponding stent ring 101.

[0049] On the first sub-bracket 110, in order to further reduce the overlap between two adjacent coagulation promoting members 200 in the same first coagulation promoting assembly, preferably, there are 1 to 3 bracket rings 101 between two adjacent coagulation promoting members 200 in the same first coagulation promoting assembly. Similarly, on any of the second sub-brackets 120, preferably, there are 1 to 3 bracket rings 101 between two adjacent coagulation promoting members 200 in the same second coagulation promoting assembly.

[0050] In some embodiments, the coagulation promoting fibers 210 of the coagulation promoting member 200 are directly connected to the stent graft 100, and the arrangement direction of the multiple coagulation promoting fibers 210 of each coagulation promoting member 200 is inclined with respect to the axis of the corresponding sub-stent. That is, the arrangement direction of the multiple coagulation promoting fibers 210 of the coagulation promoting member 200 disposed on the outer peripheral surface of the first sub-stent 110 is inclined with respect to the axis of the first sub-stent 110, and the arrangement direction of the multiple coagulation promoting fibers 210 of the coagulation promoting member 200 disposed on the outer peripheral surface of the embolization segment is inclined with respect to the axis of the corresponding second sub-stent.

[0051] Specifically, in the first coagulation promoting component, all the coagulation promoting fibers 210 of the same coagulation promoting member 200 are arranged along a first predetermined trajectory. On a plane parallel to the axis of the first sub-support 110, the projection of the first predetermined trajectory is inclined relative to the projection of the axis of the first sub-support 110. Optionally, on a plane parallel to the axis of the first sub-support 110, the projection of the first predetermined trajectory forms a third angle α with the projection of the axis of the first sub-support 110, and the angle of the third angle α is -45° to 45°. Such an arrangement further reduces the degree of overlap between the coagulation promoting fibers 210 of different coagulation promoting members 200 in the first coagulation promoting component.

[0052] And, in the second coagulation promoting component, all the coagulation promoting fibers 210 of the same coagulation promoting member 200 are arranged along a second predetermined trajectory. On a plane parallel to the axis of the second sub-bracket 120, the projection of the second predetermined trajectory is inclined relative to the projection of the axis of the second sub-bracket 120, so as to further reduce the overlap between two adjacent coagulation promoting members 200 in the same second coagulation promoting component. Optionally, on a plane parallel to the axis of the second sub-bracket 120, the projection of the second predetermined trajectory and the corresponding projection of the axis of the second sub-bracket 120 form a fourth angle β, and the angle of the fourth angle β is -45° to 45°.

[0053] The length of the coagulation promoting fiber 210 of each coagulation promoting member 200 is determined according to the position of the corresponding coagulation promoting member 200 in the tumor cavity.

[0054] Specifically, please refer to Figure 2 and Figure 3 , the diameter of the aortic aneurysm 10 first increases and then decreases along the axial direction of the abdominal aorta 23. The first sub-stent 110 includes an axially connected first segment 111 and a second segment 112, the end of the first segment 111 away from the second segment 112 is connected to the anchoring mechanism 300, and the end of the second segment 112 away from the first segment 111 is connected to two second sub-stents 120. The second segment 112 is used to be arranged in the middle part of the aortic aneurysm 10, and the first segment 111 and the embolization segment 121 are used to be arranged in the parts of the aortic aneurysm 10 close to the axial ends. That is, the second segment 112 is used to be arranged in the part with a relatively large diameter of the aortic cavity, while the first segment 111 and the embolization segment 121 are used to be arranged in the part with a relatively small diameter of the aortic cavity.

[0055] Matching this, the length of the coagulation promoting fiber 210 of the coagulation promoting member 200 disposed on the first segment 111 may be less than the length of the coagulation promoting fiber 210 of the coagulation promoting member 200 disposed on the second segment 112. Also, the length of the coagulation promoting fiber 210 of the coagulation promoting member 200 in the second coagulation promoting assembly may be less than the length of the coagulation promoting fiber 210 of the coagulation promoting member 200 disposed on the second segment 112. It should be understood that the coagulation promoting fiber 210 has two opposite ends, one end of which is connected to the corresponding sub-support (the first sub-support 110 or the second sub-support 120) and the other end is free, and the length of the coagulation promoting fiber 210 refers to the distance between the two ends of the coagulation promoting fiber 210 when the coagulation promoting fiber 210 is in a straight state. Such a setting can reduce the raw material consumption of the coagulation promoting fiber 210 as much as possible while ensuring that the blood in the tumor cavity can coagulate and block the blood flow in the tumor cavity.

[0056] Optionally, the length of the coagulation-promoting fiber 210 of the coagulation-promoting member 200 disposed on the first segment 111 and the length of the coagulation-promoting fiber 210 of the coagulation-promoting member 200 of the second coagulation-promoting assembly can be 5 mm to 50 mm. The length of the coagulation-promoting fiber 210 of the coagulation-promoting member 200 disposed on the second segment 112 is 50 mm to 100 mm.

[0057] And / or, the number of the coagulation-promoting fibers 210 of the coagulation-promoting member 200 disposed on the second segment 112 is greater than the number of the coagulation-promoting fibers 210 of the coagulation-promoting member 200 disposed on the first segment 111, and is also greater than the number of the coagulation-promoting fibers 210 of the coagulation-promoting member 200 of the second coagulation-promoting assembly. Such a configuration can also reduce the raw material consumption of the coagulation-promoting fibers 210 as much as possible while ensuring that the blood in the tumor cavity can coagulate.

[0058] Optionally, each of the support rings 101 includes a plurality of support edges (not marked in the figure) connected end to end in sequence, and two adjacent support edges form a V-shaped structure.

[0059] In some embodiments, the coagulation-promoting fibers 210 of all the coagulation-promoting members 200 of the first coagulation-promoting component are sutured to the first sub-bracket 110 by sutures. In a preferred implementation, each coagulation-promoting member 200 of the first coagulation-promoting component is arranged at one of the bracket rings 101, and the first predetermined trajectory of each coagulation-promoting member 200 overlaps with one of the bracket edges, and all the coagulation-promoting fibers 210 of the corresponding coagulation-promoting member 200 are sutured at the bracket edge by sutures of the coating 102 and the bracket ring 101. In this way, the number of suture holes generated by suturing on the coating 102 of the first sub-bracket 110 can be reduced. It should be understood that in this case, on a plane parallel to the axis of the first sub-bracket 110, the angle formed by the projection of the bracket edge in the first sub-bracket 110 and the projection of the axis of the first sub-bracket 110 is the third angle α.

[0060] In the second coagulation promoting component, the coagulation promoting fibers 210 of each coagulation promoting member 200 are sutured to the corresponding second sub-support 120 by sutures. Optionally, each coagulation promoting member 200 of the second coagulation promoting component is arranged at one of the support rings 101, and the second predetermined trajectory of each coagulation promoting member 200 overlaps with one of the support edges, and all the coagulation promoting fibers 210 of the corresponding coagulation promoting member 200 are sutured at the support edge by sutures of the covering film 102 and the support ring 101. It should be understood that in this case, on a plane parallel to the axis of the second sub-support 120, the angle formed by the projection of the support edge in the second sub-support 120 and the projection of the axis of the second sub-support 120 is the fourth angle β.

[0061] In addition, a coagulation-promoting coating (not shown) may be provided on the outer surface of the coagulation-promoting fiber 210 of at least part of the coagulation-promoting member 200 in the above embodiment. Preferably, the coagulation-promoting coating is provided on the outer surface of the shaping portion 220 and the coagulation-promoting fiber 210 of all the coagulation-promoting members 200. The provision of the coagulation-promoting coating can accelerate the formation of blood clots and increase the speed at which the blood in the tumor cavity coagulates and fills the tumor cavity. The coagulation-promoting coating may include a hydrogel.

[0062] In an alternative embodiment, please refer to Figures 4 to 6 Each of the coagulation promoting members 200 includes a self-expanding shaping portion 220 and a coagulation promoting fiber 210 attached to the outer surface of the shaping portion 220. One end of the shaping portion 220 is connected to the stent graft 100, and the other end is a free end, and the shaping portion 220 is at least partially pre-shaped into a three-dimensional structure. In a typical implementation, the shaping portion 220 is at least partially pre-shaped into a three-dimensional spiral structure 221.

[0063] When the medical stent system is implanted in a blood vessel, Figure 7 As shown, the self-expanding shaping portion 220 automatically expands to a shape having the three-dimensional spiral structure 221, and the coagulation-promoting fiber 210 follows the expansion of the shaping portion 220 and stretches freely in the tumor cavity, so that the coagulation-promoting fiber 210 will not collapse under the impact of blood to the outer surface of the stent graft (including the first sub-stent 110 and the second sub-stent 120). In addition, the shaping portion 220 itself can also be filled in the tumor cavity. In this way, the coagulation-promoting member 200 can promote blood coagulation well and increase the speed of blood coagulation in the tumor cavity. In addition, by arranging the coagulation-promoting fiber 210 in this way, it is also possible to avoid the coagulation-promoting fiber 210 from being knotted due to blood reflux. The shaping portion 220 can be made of shape memory alloy such as nickel-titanium alloy or other highly elastic materials, which are pre-shaped to have the shape of the three-dimensional spiral structure 221.

[0064] It should be understood that in these embodiments, the arrangement of the coagulation promoting members 200 is the same as described above. That is, all the first coagulation promoting members are arranged at intervals along the circumference of the first sub-bracket 110, and all the coagulation promoting members 200 of the same first coagulation promoting member are arranged at intervals along the axial direction of the first sub-bracket 110, and are arranged spirally around the axis of the first sub-bracket 110. Also, all the second coagulation promoting members located on the same embolization segment 121 are arranged at intervals along the circumference of the corresponding second sub-bracket 120, and all the coagulation promoting members 200 of the same second coagulation promoting member are arranged at intervals along the axial direction of the corresponding second sub-bracket 120, and are arranged spirally around the axis of the corresponding second sub-bracket 120.

[0065] Further, in the first coagulation promoting component, the axis of the three-dimensional helical structure 221 is inclined relative to the axis of the first sub-bracket 110. And, in the second coagulation promoting component, the axis of the three-dimensional helical structure 221 of the shaping portion 220 is inclined relative to the corresponding axis of the second sub-bracket 120.

[0066] In the first coagulation promoting component, the axis of the three-dimensional spiral structure 221 of the coagulation promoting component 200 forms a first angle γ with the axis of the first sub-support 110, and the angle of the first angle γ is -45° to 45°. In the second coagulation promoting component, the axis of the three-dimensional spiral structure 221 of the coagulation promoting component 200 forms a second angle δ with the axis of the second sub-support 120 connected thereto, and the angle of the second angle δ is -45° to 45°.

[0067] In these embodiments, the axial length of the shaping portion 220 connected to the second segment 112 is greater than the axial length of the shaping portion 220 connected to the first segment 111, and is also greater than the axial length of the shaping portion 220 connected to the second sub-bracket 120. The axial direction of the shaping portion 220 refers to the axial direction of the three-dimensional spiral structure 221 of the shaping portion 220.

[0068] Optionally, the length of the shaping portion 220 connected to the first segment 111 in its axial direction is 5mm to 20mm, and the length of the shaping portion 220 connected to the second segment 112 in its axial direction is 15mm to 50mm. The length of the shaping portion 220 connected to the second sub-stent 120 in its axial direction is 5mm to 20mm. In this way, the coagulation promoting member 200 located at various parts in the tumor cavity can fully fill the tumor cavity, effectively slow down the flow rate of blood in the tumor cavity, and promote blood coagulation. In these embodiments, at least part of the shaping portion 220 of the coagulation promoting member 200 and / or the coagulation promoting fiber 210 are also provided with a coagulation promoting coating (not shown in the figure) on the outer surface. Preferably, the shaping portion 220 and the coagulation promoting fiber 210 of all the coagulation promoting members 200 are provided with the coagulation promoting coating on their outer surfaces. The provision of the coagulation promoting coating can accelerate the formation of blood clots and increase the speed at which the blood in the tumor cavity coagulates and fills the tumor cavity. The coagulation promoting coating may include a hydrogel.

[0069] In summary, the medical stent system provided by the embodiment of the present invention, by arranging a coagulant on the outer peripheral surface of the coated stent, can use the coagulant to slow down the blood flow rate in the aneurysm cavity during the treatment of aneurysms, promote blood clotting and fill the aneurysm cavity, thereby reducing the occurrence of type II endoleak. In particular, when the coagulant includes a shaping portion and coagulant fibers attached thereto, the shaping portion can prevent the coagulant fibers from collapsing and attaching to the coated stent, thereby allowing the coagulant to effectively fill the aneurysm cavity and further promote blood clotting in the aneurysm cavity.

[0070] Although the present invention is disclosed as above, it is not limited thereto. Those skilled in the art may make various changes and modifications to the present invention without departing from the spirit and scope of the present invention. Thus, if these modifications and variations of the present invention fall within the scope of the claims of the present invention and their equivalents, the present invention is also intended to include these modifications and variations.

Claims

1. A medical stent system, characterized in that: It comprises a stent graft and a coagulant member arranged on the outer peripheral surface of the stent graft, wherein the coagulant member comprises a plurality of coagulant fibers for filling the tumor cavity to slow down the flow rate of blood entering the tumor cavity and promote blood coagulation in the tumor cavity.

2. The medical stent system according to claim 1, characterized in that: The coagulation promoting member also includes a self-expanding shaping portion, the coagulation promoting fiber is attached to the shaping portion, one end of the shaping portion is connected to the stent graft, and the other end is a free end; the shaping portion is at least partially pre-shaped into a three-dimensional structure.

3. The medical stent system according to claim 1 or 2, characterized in that: All the coagulation-promoting components are divided into a plurality of coagulation-promoting components, and each of the coagulation-promoting components includes a plurality of the coagulation-promoting components; All the coagulation promoting components are arranged at intervals along the circumference of the coated stent; all the coagulation promoting elements of the same coagulation promoting component are arranged at intervals along the axial direction of the coated stent and are arranged spirally around the axis of the coated stent.

4. The medical stent system according to claim 1 or 2, characterized in that: The coated stent includes a first sub-stent and two second sub-stents, the two second sub-stents are connected in parallel to the same axial end of the first sub-stent and are respectively connected to the first sub-stent; some segments of the second sub-stent are embolic segments; the coagulation promoter is provided on the outer peripheral surface of the first sub-stent and the outer peripheral surface of each of the embolic segments.

5. The medical stent system according to claim 4, characterized in that: All the coagulants arranged on the first sub-support are divided into a plurality of first coagulant assemblies, each of which includes a plurality of coagulants; all the first coagulant assemblies are arranged at intervals along the circumference of the first sub-support; all the coagulants of the same first coagulant assembly are arranged at intervals along the axial direction of the first sub-support and are arranged spirally around the axis of the first sub-support; and / or, all the coagulants on each embolization segment are divided into a plurality of second coagulant assemblies, each of which includes a plurality of coagulants; all the second coagulant assemblies located on the same embolization segment are arranged at intervals along the circumference of the corresponding second sub-support; all the coagulants of the same second coagulant assembly are arranged at intervals along the axial direction of the corresponding second sub-support and are arranged spirally around the axis of the corresponding second sub-support.

6. The medical stent system according to claim 5, characterized in that: The first sub-stent comprises a plurality of stent rings spaced apart along its axial direction, and there are 1 to 3 stent rings spaced apart between two adjacent stent members of the same first stent assembly; and / or, Each of the second sub-supports comprises a plurality of support rings spaced apart along the axial direction thereof, and there are 1 to 3 support rings spaced apart between two adjacent coagulation promoting members of the same second coagulation promoting component.

7. The medical stent system according to claim 4, characterized in that: The coagulation promoter disposed on the outer circumference of the first sub-support is inclined relative to the axis of the first sub-support; and / or the coagulation promoter disposed on the outer circumference of the embolization segment is inclined relative to the corresponding axis of the second sub-support.

8. The medical stent system according to claim 4, characterized in that: The first sub-bracket comprises a first segment and a second segment connected axially, and one end of the second segment away from the first segment is connected to two second sub-brackets; The length of the coagulation-promoting fiber of the coagulation-promoting member arranged on the first segment is 5 mm to 50 mm, and the length of the coagulation-promoting fiber of the coagulation-promoting member arranged on the second segment is 50 mm to 110 mm; The length of the coagulation-promoting fiber of the coagulation-promoting member arranged on the second sub-bracket is 5 mm to 50 mm; and / or, The number of the coagulation-promoting fibers of each of the coagulation-promoting elements arranged on the first segment is smaller than the number of the coagulation-promoting fibers of each of the coagulation-promoting elements arranged on the second segment; the number of the coagulation-promoting fibers of each of the coagulation-promoting elements arranged on the second segment is larger than the number of the coagulation-promoting fibers of each of the coagulation-promoting elements arranged on the second sub-bracket.

9. The medical stent system according to claim 2, characterized in that: The coated stent comprises a first sub-stent and two second sub-stents, the two second sub-stents are connected in parallel to the same axial end of the first sub-stent and are respectively connected to the first sub-stent; the first sub-stent comprises an axially connected first segment and a second segment, the second segment is connected to the two second sub-stents at one end away from the first segment; some segments of the second sub-stent are embolization segments; the coagulation promoter is provided on the outer peripheral surface of the first sub-stent and the outer peripheral surface of each of the embolization segments; The axial length of the shaping portion of the coagulation promoter arranged on the first segment is 5mm to 20mm, and the axial length of the shaping portion of the coagulation promoter arranged on the second segment is 15mm to 50mm; and / or the axial length of the shaping portion arranged on the embolization segment is 5mm to 20mm.

10. The medical stent system according to claim 1 or 2, characterized in that: A coagulation-promoting coating is provided on at least a portion of the outer surface of the coagulation-promoting member.

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