Traditional Chinese medicine composition for treating upper limb lymphedema after breast cancer operation and application thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating upper limb lymphedema after a breast cancer operation and application of the traditional Chinese medicine composition. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicines in parts by weight: 10-15 parts of radix salviae miltiorrhizae, 10-15 parts of radix angelicae sinensis, 10-15 parts of poria cocos, 10-15 parts of radix paeoniae rubra, 10-15 parts of garden balsam stem, 10-15 parts of radix dipsaci, 10-15 parts of caulis spatholobi, 5-10 parts of rhizoma amorphophalli, 5-10 parts of radix clematidis and 5-10 parts of rhizoma cyperi. The traditional Chinese medicine composition conforms to the compatibility principle of monarch, minister, assistant and guide, is safe, economical and free of obvious toxic and side effects, has the effects of replenishing qi to invigorate the spleen, reducing phlegm and resolving masses, and is suitable for patients with upper limb lymphedema after breast cancer operation; clinical research proves that the traditional Chinese medicine composition can improve clinical symptoms of patients with upper limb lymphedema after the breast cancer operation in a traditional Chinese medicine wet-hot compress mode, the curative effect is remarkable, and the traditional Chinese medicine composition has important clinical application value.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and in particular to a traditional Chinese medicine composition for treating upper limb lymphedema after breast cancer surgery and application thereof. Background Art

[0002] Breast cancer-related lymphedema (BCRL) is caused by edema caused by lymphatic system circulation disorders after breast cancer surgery, radiotherapy or tumor metastasis, which leads to obstruction of the return of protein-rich lymph fluid and retention in the interstitial space. Early symptoms include transient swelling, fatigue and pain in the ipsilateral arm, breast or trunk, and stiffness of the ipsilateral arm joints. In severe cases, blisters, burning pain, muscle weakness, and infection may occur in the affected limb. Lymphedema of the upper limb on the side affected by breast cancer is a common complication of axillary lymph node dissection and axillary radiotherapy. The degree of lymphedema is related to individual factors. Some patients have underdeveloped upper limb lymphatic vessels and are prone to lymphedema. The incidence of postoperative lymphedema is high in elderly and obese breast cancer patients.

[0003] The time of upper limb lymphedema after breast cancer surgery generally ranges from 3 months to 10 years after surgery. Its incidence varies depending on the research design, follow-up time or evaluation method. The incidence of BCRL can reach 41.1% to 49% within 10 years after surgery, and the incidence of BCRL can reach 39% to 42% within 1 year after surgery. With the increase in the number of breast cancer patients, the number of BCRLs is likely to increase further. Acute lymphedema manifests as thickening of the affected upper limb. If the circumference of the upper limb increases by more than 2 cm, it can be seen with the naked eye. Chronic lymphedema presents as rubber-like swelling of the upper arm. Lymphedema can cause pain, limb deformity, and dysfunction in the affected upper limb, and can be secondary to infection. The infection further causes sclerosis and occlusion of the lymphatic lumen, aggravating edema. The International Lymphatic Society divides it into the following three stages: Stage I: pitting edema of the upper limbs, which disappears when the limbs are raised; Stage II: the edema is non-pitting, the upper limb tissues have moderate fibrosis, and the edema does not disappear when the limbs are raised; Stage III: rubber swelling, the upper limbs have cartilage-like hardness, and the skin has exophytic papilloma. According to the scope and degree of edema, it is divided into three degrees: Grade I: the volume of the upper arm increases by <10%, which is generally not obvious and difficult to detect with the naked eye. It often occurs in the inner and posterior sides of the proximal upper arm; Grade II: the volume of the upper arm increases by 10% to 80%, and the swelling is obvious, but it generally does not affect the movement of the upper limbs; Grade III (severe): the volume of the upper arm increases by 80%, the swelling is significant, the involvement range is wide, it can affect the entire upper limb, and there are serious upper limb movement disorders.

[0004] Mild upper limb lymphedema after surgery can be relieved within a few months, but severe upper limb swelling is difficult to recover on its own. Various non-surgical and surgical treatments have limited effects. The treatment of upper limb lymphedema after breast cancer surgery is to reduce the accumulation of lymph fluid and improve lymphatic return to obtain long-term relief and avoid recurrence. This is a hot topic of research at home and abroad. Summary of the invention

[0005] In view of the deficiencies in the prior art, the main purpose of the present invention is to provide a traditional Chinese medicine composition for treating upper limb lymphedema after breast cancer surgery. The traditional Chinese medicine composition has a significant therapeutic effect on upper limb lymphedema after breast cancer surgery, can alleviate the patient's pain, and improve the patient's treatment quality and effect.

[0006] Another object of the present invention is to provide the use of the above-mentioned traditional Chinese medicine composition for treating upper limb lymphedema after breast cancer surgery in the preparation of medicines.

[0007] In order to achieve the above object, the present invention provides the following technical solutions:

[0008] The first aspect of the present invention provides a traditional Chinese medicine composition for treating upper limb lymphedema after breast cancer surgery, comprising the following traditional Chinese medicines: 10-15 parts by weight of Salvia miltiorrhiza, 10-15 parts by weight of Angelica sinensis, 10-15 parts by weight of Poria cocos, 10-15 parts by weight of Red Peony Root, 10-15 parts by weight of Herba Polygoni Multiflori, 10-15 parts by weight of Dipsacus asper, 10-15 parts by weight of Millettia reticulata, 5-10 parts by weight of Herba Cephalotaxus, 5-10 parts by weight of Clematis chinensis, and 5-10 parts by weight of Cyperus rotundus.

[0009] Preferably, the Chinese medicine composition comprises the following Chinese medicines: 10 parts by weight of Salvia miltiorrhiza, 10 parts by weight of Angelica sinensis, 10 parts by weight of Poria cocos, 10 parts by weight of Paeonia lactiflora, 10 parts by weight of Herba Polygoni Multiflori, 10 parts by weight of Dipsacus asper, 10 parts by weight of Millettia spatholobi, 5 parts by weight of Herba Cephalotaxus, 5 parts by weight of Clematis chinensis, and 5 parts by weight of Cyperus rotundus.

[0010] Preferably, the Chinese medicine composition comprises the following Chinese medicines: 15 parts by weight of Salvia miltiorrhiza, 15 parts by weight of Angelica sinensis, 15 parts by weight of Poria cocos, 15 parts by weight of Paeonia lactiflora, 15 parts by weight of Herba Polygoni Multiflori, 15 parts by weight of Dipsacus asper, 15 parts by weight of Millettia spatholobi, 10 parts by weight of Herba Cephalotaxus, 10 parts by weight of Clematis chinensis, and 10 parts by weight of Cyperus rotundus.

[0011] The meridian entry, function, main treatment and mechanism of action of each medicinal material used in the present invention are as follows:

[0012] Salvia miltiorrhiza: belongs to the Lamiaceae family and the genus Salvia; it is bitter and slightly cold in nature; it enters the heart and liver meridians; it has the functions of promoting blood circulation and removing blood stasis, relieving menstruation and pain, clearing the heart and relieving restlessness; it is used for accumulation of masses, pain caused by heat arthralgia, and swelling and pain caused by sores; its pharmacological effects include dilating coronary arteries, anti-platelet aggregation, anti-oxidation, anti-inflammatory, and improving microcirculation; remove the soil, dry in the sun or in an oven, and slice for later use.

[0013] Angelica: Belongs to the Apiaceae family, Angelica sinensis; sweet, pungent and warm in nature; enters the liver, heart and spleen meridians; has the functions of nourishing blood and activating blood circulation, regulating menstruation and relieving pain, moistening the intestines and promoting bowel movements, and protecting skin and beautifying; pharmacological effects include nourishing blood, dilating blood vessels, anti-thrombosis, anti-oxidation, enhancing immunity, and anti-inflammation; remove the dirt, dry in the sun or in an oven, and slice for later use. There are three processing methods for angelica: "whole angelica", "head", "body" and "tail", and the effects of different parts are slightly different.

[0014] Poria: Belongs to the Polyporaceae family, Poria genus; sweet, light, flat in nature; enters the heart, lung, spleen, and kidney meridians; has the functions of diuresis, invigorating the spleen and calming the mind, tranquilizing the nerves, and anti-tumor; used for edema, spleen and stomach weakness such as indigestion, restlessness, and adjuvant treatment of tumors to improve immunity and reduce the side effects of radiotherapy and chemotherapy. Pharmacological effects include diuresis, enhancing immunity, anti-tumor, antioxidant, anti-inflammatory, sedative and tranquilizing the nerves; remove the soil, dry in the sun or bake, slice for later use, the processing methods of Poria include "white Poria", "red Poria" and "Fu Shen", and the effects of different parts are slightly different.

[0015] Red Peony Root: Belongs to the Paeoniaceae family, Paeonia genus; bitter and slightly cold in nature; enters the liver and spleen meridians; has the functions of clearing heat and cooling blood, dispersing blood stasis and relieving pain, and promoting blood circulation and removing blood stasis; pharmacological actions include anti-inflammatory and antibacterial activity, anti-tumor activity, liver protection, and blood pressure reduction.

[0016] Herba Lycopodii: belongs to the Euphorbiaceae family and the genus Euphorbia; it is pungent and warm in nature; it enters the liver and kidney meridians; it has the functions of dispelling wind and dampness, promoting blood circulation and relieving pain, detoxifying and reducing swelling; its pharmacological effects include anti-inflammatory and antibacterial, analgesic, anti-tumor, and liver protection; it should not be used together with Veratrum (Eighteen Antidotes); remove impurities, dry in the sun or in an oven, and cut into sections for later use.

[0017] Dipsacus: Belongs to the Dipsacus family and the Dipsacus genus; bitter, pungent and slightly warm in nature; enters the liver and kidney meridians; has the functions of nourishing the liver and kidneys, strengthening the tendons and bones, and stopping bleeding and promoting muscle growth; pharmacological effects include promoting fracture healing, reducing inflammatory responses, relieving pain, inhibiting the growth of various bacteria, and improving the body's immunity; should not be used together with Veratrum (Eighteen Antidotes).

[0018] Millettia reticulata: belongs to the Leguminosae family, Millettia genus; bitter, sweet and warm in nature; enters the liver and kidney meridians; has the functions of promoting blood circulation, dispelling wind and unblocking meridians, and relaxing muscles and tendons; pharmacological effects include dilating blood vessels to improve blood circulation, reducing inflammatory responses, relieving pain, and scavenging free radicals to protect cells; should not be used together with Veratrum (Eighteen Antidotes).

[0019] Snake Six Valley: Belongs to the Araceae family, Plowshare genus; It is pungent, bitter, cold and poisonous in nature; It enters the lung, stomach and liver meridians; It has the functions of clearing away heat and detoxifying, reducing swelling and dispersing nodules, resolving phlegm and relieving cough; The pharmacological effects include anti-inflammatory and antibacterial, anti-tumor, and pain relief; It should not be used in excess, as it may cause poisoning; It needs to be processed before use to reduce toxicity.

[0020] Clematis: Belongs to the Ranunculaceae family, Clematis genus; spicy, salty, warm, and slightly toxic; enters the liver, kidney, and bladder meridians; has the functions of dispelling wind and dampness, dredging meridians and relieving pain, and eliminating phlegm and dispersing nodules; pharmacological effects include anti-inflammatory and antibacterial, analgesic, anti-tumor, and liver protection; should not be used together with Veratrum (Eighteen Anti-Reactions).

[0021] Cyperus rotundus: belongs to the Cyperaceae family, Cyperus genus; it is pungent, slightly bitter, and neutral in nature; it enters the liver, spleen, and triple burner meridians; it has the functions of soothing the liver and regulating qi, regulating menstruation and relieving pain, and promoting qi and relieving fullness; its pharmacological effects include anti-inflammatory, antibacterial, sedative and analgesic.

[0022] In the above-mentioned Chinese medicine composition of the present invention, Herba Clematis and Herba Cyperi are toxic and should be used with caution and not in excessive amounts; Herba Cyperi has a strong effect of regulating qi and should be used to avoid excessive qi-draining; Radix Salviae Miltiorrhizae, Radix Angelicae Sinensis and Radix Paeoniae Rubra are used for promoting blood circulation and removing blood stasis, and have better effects on patients with blood stasis syndrome; Poria, Radix Polygoni Multiflori and Radix Dipsaci are used for removing dampness and strengthening tendons and bones, and are suitable for patients with rheumatic arthralgia and tendon and bone injuries.

[0023] The second aspect of the present invention also provides the use of the traditional Chinese medicine composition in the preparation of a medicine for treating upper limb lymphedema after breast cancer surgery.

[0024] Preferably, the mixture of the effective ingredients of the traditional Chinese medicine composition after extraction is prepared into a pharmaceutically acceptable drug preparation.

[0025] Preferably, the pharmaceutical preparation comprises an extract of the above-mentioned traditional Chinese medicine composition and a pharmaceutically acceptable drug carrier or excipient, and the dosage form includes decoction, granules, pills, capsules, ointments, tablets, powders, granules, suspensions or injections.

[0026] More preferably, the pharmaceutical preparation is a granule, and the preparation method comprises: taking salvia miltiorrhiza, angelica sinensis, Poria cocos, red peony root, herbaceous radix polygoni lobatae, Dipsacus asper, Millettia spatholobi, Herba Cephalotaxus, Radix Clematis, and Rhizoma Cyperi respectively according to the raw materials and weight ratio of the traditional Chinese medicine composition, selecting, and coarsely chopping them respectively to obtain coarse granules of the medicinal materials; soaking in water 8 to 10 times the mass of the raw materials, decocting for 2 to 3 times, each time for 1.5 to 2 hours, combining the decocted medicinal liquids, concentrating to a clear paste with a relative density of 1.12 to 1.15, drying and grinding into fine powder at 130 to 160° C., sieving, adding an appropriate amount of excipient, mixing, making into granules, and drying.

[0027] More preferably, the drug preparation is a pill, and the preparation method comprises: taking Danshen, Angelica, Poria, Red Peony Root, Polygonum Multiflorum, Dipsacus Asper, Millettia Spatholobi, Herba Clematis, and Cyperus rotundus respectively according to the raw materials and weight ratio of the Chinese medicine composition, selecting, and coarsely chopping them respectively to obtain coarse particles of the medicinal materials; soaking in water 8 to 10 times the mass of the raw materials, decocting for 2 to 3 times, each time for 1.5 to 2 hours, combining the decocted medicinal liquids, concentrating to a clear paste with a relative density of 1.12 to 1.15, drying and grinding into fine powder at 130 to 160° C., sieving, adding an appropriate amount of excipients, mixing, making into granules, drying, and then making into water-honeyed pills.

[0028] More preferably, the pharmaceutical preparation is a capsule, and the preparation method comprises: taking salvia miltiorrhiza, angelica sinensis, Poria cocos, red peony root, herbaceous radix polygoni lobatae, Dipsacus asper, Millettia spatholobi, Herba Cephalotaxus, Radix Clematis, and Rhizoma Cyperi according to the raw materials and weight ratio of the traditional Chinese medicine composition, selecting them, and coarsely crushing them respectively to obtain coarse particles of the medicinal materials; soaking them in water 8 to 10 times the mass of the raw materials, decocting them for 2 to 3 times, each time for 1.5 to 2 hours, combining the decocted medicinal liquids, concentrating them to a clear paste with a relative density of 1.12 to 1.15, drying and grinding them into fine powder at 130 to 160° C., sieving, adding an appropriate amount of excipients, mixing them evenly, making them into granules, drying them, and filling them into capsules.

[0029] More preferably, the pharmaceutical preparation is a decoction, and the preparation method comprises: taking Danshen, Angelica, Poria, Red Peony Root, Polygonum Multiflorum, Dipsacus Asper, Millettia Spatholobi, Herba Cephalostachys Officinalis, Radix Clematis, and Rhizoma Cyperi respectively according to the raw materials and weight ratio of the Chinese medicine composition, selecting, and coarsely chopping them respectively to obtain coarse particles of the medicinal materials; soaking them in water 3 to 10 times the mass of the raw materials for 60 minutes, then decocting them to a boil over high heat, then decocting them over low heat for 2 to 3 times, each time for 0.5 to 2 hours, combining the decoctions, concentrating them and keeping them warm at 40°C to obtain the decoction.

[0030] As a more preferred method, a Chinese medicine wet hot compress is used for administration, and the method of use includes: completely soaking the medical gauze in the decoction, exposing the affected limb, placing the medical gauze containing the medicinal solution on the swollen part of the patient's upper limb and the corresponding acupoints, respectively, wrapping the outer layer with a film for heat preservation, and the wet compress lasts for 10 to 20 minutes, once a day, wherein the acupoints include Jianyu, Quchi, Neiguan, Hegu and Fenglong.

[0031] The present invention is based on the concept of "preventive treatment" in traditional Chinese medicine. Long-term clinical evidence shows that the aforementioned Chinese medicine composition of the present invention has the effects of clearing away heat, detoxifying, anti-inflammatory, cooling blood, removing blood stasis, and reducing swelling. It is suitable for treating upper limb lymphedema after breast cancer surgery. The external treatment ingredients of traditional Chinese medicine are safe and will not cause adverse effects on patients. Compared with the prior art, the Chinese medicine composition of the present invention is used to prepare a drug for treating upper limb lymphedema after breast cancer surgery, which can significantly improve the clinical symptoms of patients with upper limb lymphedema after breast cancer surgery, has significant therapeutic effects, and has a high clinical application value in treating upper limb lymphedema after breast cancer surgery. DETAILED DESCRIPTION

[0032] In order to make the purpose, technical solution and advantages of the embodiments of the present invention clearer, the technical solution of the embodiments of the present invention is clearly and completely described in combination with the embodiments of the present invention. Obviously, the described embodiments are part of the embodiments of the present invention, not all of the embodiments. Based on the described embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work belong to the scope of protection of the present invention.

[0033] The Chinese medicine ointment used in the following embodiments comprises the following Chinese medicines: 15 parts by weight of Salvia miltiorrhiza, 15 parts by weight of Angelica sinensis, 15 parts by weight of Poria cocos, 15 parts by weight of Red Peony Root, 15 parts by weight of Herba Polygoni Multiflori, 15 parts by weight of Dipsacus asper, 15 parts by weight of Millettia spatholobi, 10 parts by weight of Herba Cephalotaxus, 10 parts by weight of Radix Clematis, and 10 parts by weight of Rhizoma Cyperi.

[0034] Example 1

[0035] The following examples are clinical trials to observe and evaluate the clinical efficacy of the Chinese medicine composition of the present invention in treating upper limb lymphedema after breast cancer surgery.

[0036] 1. General Information

[0037] Patients with BCRL who received comprehensive detumescence treatment in the Seventh People's Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from March 2019 to December 2021 were selected and divided into a treatment group and a control group according to the random number table method, with 40 cases in each group.

[0038] 2. Evaluation indicators

[0039] (1) Arm circumference: Measure the circumference of the wrist creases and 10 cm, 20 cm, and 40 cm above the wrist creases on both sides of the arm. Each measurement point needs to be measured twice, and the average of the two measurements is taken as the circumference of the measurement point. Calculate the difference in circumference values ​​at different measurement points on both sides of the arm, and use the maximum difference as the statistical data.

[0040] (2) Upper limb function: The diagnostic upper limb function scale (DASH) was used to assess upper limb functional mobility. DASH includes two parts: daily living activities and upper limb discomfort symptoms and their interference, with a total of 30 items. Each item is scored according to a 5-point rating system, such as no difficulty (1 point), a little difficult (2 points), obviously difficult but able to do (3 points), very difficult (4 points), and unable to do (5 points). The standardized score (i.e., DASH score) was calculated according to (DASH total score - 30) / 1.2. The score range is 0 to 100 points, and the lower the score, the better the function. The intraclass correlation coefficient and Cronbach's α coefficient of the Chinese version of the scale were 0.77 and 0.94, respectively, indicating that the scale has good reliability and validity.

[0041] (3) Exclusion criteria: ① Upper limb edema caused by thrombotic diseases, lymphangitis or other non-breast cancer surgery; ② The skin of the affected limb has papules, exfoliative dermatitis or trauma, ulceration, etc., which affect the comprehensive detumescence treatment and TCM operation, and the patient is allergic to topical drugs or dressings and is not suitable for TCM operation; ③ Accompanied by severe heart, liver, kidney, and brain function damage.

[0042] 3. Methods

[0043] Control group: After admission, the patients were given comprehensive detumescence treatment by specialist nurses who obtained the international lymphedema therapist qualification. Treatment group: On the basis of the treatment of the control group, the observation group was given Chinese medicine hot compress by nurses with a background in traditional Chinese medicine and 100 hours of training in traditional Chinese medicine. The ingredients included: 15 parts by weight of salvia miltiorrhiza, 15 parts by weight of angelica sinensis, 15 parts by weight of Poria cocos, 15 parts by weight of red peony root, 15 parts by weight of radix spatholobi, 15 parts by weight of dipsacchariflora, 15 parts by weight of Millettia spatholobi, 10 parts by weight of ophiopogonis, 10 parts by weight of clematis root, and 10 parts by weight of cyperus rotundus. The process is as follows: add water to the above-mentioned traditional Chinese medicine to boil 200mL of liquid medicine, put it into a constant temperature box, set the temperature to 40℃, completely immerse the medical gauze in the liquid medicine, expose the affected limb, and place the medical gauze containing the liquid medicine on the swollen part of the upper limb and related acupoints (the acupoints are Jianyu, Quchi, Neiguan, Hegu, and Fenglong), wrap the outer layer with a film to keep warm, and the wet compress lasts for 15 minutes.

[0044] 4. Results

[0045] 4.1 Comparison of the difference in arm circumference measurement and DASH score between the two groups of patients Before the intervention, there was no significant difference in the difference in arm circumference measurement between the two groups of patients (P>0.05); after the intervention, there was a significant difference in the difference in arm circumference measurement between the two groups of patients (P<0.05). There was no significant difference in the DASH score between the two groups of patients before the intervention (P>0.05); after the intervention, there was a significant difference in the DASH score (P<0.05), as shown in Table 1.

[0046] Table 1: Comparison of the difference in arm circumference and DASH scores between the two groups of patients

[0047]

[0048] Table 2: Comparison of BCLE-SEI scores between the two groups before intervention

[0049]

[0050] 5. Conclusion

[0051] The treatment group (TCM moist heat compress external application group) was superior to the control group in reducing the arm circumference of the affected limb and improving the function of the affected limb in patients with moderate to severe BCRL, and it has certain value in clinical application and reference.

[0052] The technical content of the present invention is specifically described and further elaborated below in conjunction with typical cases, but these typical cases are by no means limiting the present invention in any way.

[0053] The following traditional Chinese medicines were used: 15 parts by weight of Salvia miltiorrhiza, 15 parts by weight of Angelica sinensis, 15 parts by weight of Poria cocos, 15 parts by weight of Red Peony Root, 15 parts by weight of Herba Polygoni Multiflori, 15 parts by weight of Dipsacus asper, 15 parts by weight of Millettia spatholobi, 10 parts by weight of Herba Cephalotaxus, 10 parts by weight of Radix Clematis, and 10 parts by weight of Rhizoma Cyperi. The above medicinal materials are cleaned and coarsely chopped to obtain coarse medicinal particles; water of 3 to 10 times the mass of the raw materials is added for soaking for 60 minutes, then boiled over high heat, and then simmered over low heat for 2 to 3 times, each time for 0.5 to 2 hours, the decoctions are combined, concentrated to 200 mL of liquid medicine, and placed in a constant temperature box at a temperature of 40°C, and medical gauze is completely immersed in the liquid medicine, the affected limb is exposed, and the medical gauze containing the liquid medicine is placed on the swollen part of the upper limb and related acupoints (the acupoints are Jianyu, Quchi, Neiguan, Hegu, and Fenglong), and the outer layer is wrapped with a film for heat preservation, and the wet compress lasts for 15 minutes.

[0054] Case 1

[0055] Wang, 63 years old, female, Shanghai Seventh People's Hospital, hospital number: 68**11

[0056] The patient complained that 2 years after modified radical mastectomy for breast cancer, she found swelling, tightness, and discomfort in her left upper arm. The difference in arm circumference was 4 cm, which was diagnosed as stage II edema. She was given the above-mentioned Chinese medicine hot compress once a day as prescribed by the doctor. After 4 weeks, the difference in arm circumference was 1 cm.

[0057] Case 2

[0058] Liu, 68 years old, female, Shanghai Seventh People's Hospital, hospital number: 68**24

[0059] The patient complained that she had undergone modified radical mastectomy for breast cancer 10 years ago and found that her right upper limb had edema for more than 3 months, felt tight and uncomfortable, had repeated infections, and had severe limited activities. The difference in arm circumference was 7cm, which was judged as stage III edema. According to the doctor's advice, she was given Chinese medicine hot compress once a day. After 4 weeks, the difference in arm circumference was 3cm.

[0060] The above description is only a specific implementation mode of the present invention, but the protection scope of the present invention is not limited thereto. Any technician familiar with the technical field can easily think of changes or substitutions within the technical scope disclosed by the present invention, which should be covered by the protection scope of the present invention.

Claims

1. A Chinese medicine composition for treating upper limb lymphedema after breast cancer surgery, characterized in that: The Chinese medicine composition comprises the following Chinese medicines: 10-15 weight parts of salvia miltiorrhiza, 10-15 weight parts of angelica sinensis, 10-15 weight parts of poria cocos, 10-15 weight parts of red peony root, 10-15 weight parts of radix polygoni lobatae, 10-15 weight parts of dipsaci, 10-15 weight parts of millettia reticulatae, 5-10 weight parts of ophiopogonis, 5-10 weight parts of clematis, and 5-10 weight parts of cyperus rotundus.

2. The Chinese medicine composition for treating upper limb lymphedema after breast cancer surgery according to claim 1, characterized in that: The Chinese medicine composition comprises the following Chinese medicines: 10 parts by weight of Salvia miltiorrhiza, 10 parts by weight of Angelica sinensis, 10 parts by weight of Poria cocos, 10 parts by weight of Paeonia lactiflora, 10 parts by weight of Herba Polygoni Multiflori, 10 parts by weight of Dipsacus asper, 10 parts by weight of Millettia spatholobi, 5 parts by weight of Herba Cephalotaxus, 5 parts by weight of Radix Clematis, and 5 parts by weight of Rhizoma Cyperi.

3. The Chinese medicine composition for treating upper limb lymphedema after breast cancer surgery according to claim 1, characterized in that: The Chinese medicine composition comprises the following Chinese medicines: 15 parts by weight of Salvia miltiorrhiza, 15 parts by weight of Angelica sinensis, 15 parts by weight of Poria cocos, 15 parts by weight of Paeonia lactiflora, 15 parts by weight of Herba Polygoni Multiflori, 15 parts by weight of Dipsacus asper, 15 parts by weight of Millettia spatholobi, 10 parts by weight of Herba Cephalotaxus, 10 parts by weight of Radix Clematis, and 10 parts by weight of Rhizoma Cyperi.

4. Use of the Chinese medicine composition for treating upper limb lymphedema after breast cancer surgery according to any one of claims 1 to 3 in the preparation of a medicament for treating upper limb lymphedema after breast cancer surgery.

5. The use according to claim 4, characterized in that: The effective components of the traditional Chinese medicine composition are extracted and mixed to prepare a pharmaceutically acceptable drug preparation.

6. The use according to claim 5, characterized in that: The pharmaceutical preparation comprises the extract of the above-mentioned traditional Chinese medicine composition and a pharmaceutically acceptable drug carrier or excipient, and the dosage forms include decoction, granules, pills, capsules, ointments, tablets, powders, granules, suspensions or injections.

7. The use according to claim 6, characterized in that: The pharmaceutical preparation is a granule, and the preparation method comprises: taking salvia miltiorrhiza, angelica sinensis, tuckahoe, red peony root, radix polygoni lobatae, dipsaci, millet spatholobi, ophiopogonis, clematis root, and cyperus rotundus according to the raw materials and weight ratio of the traditional Chinese medicine composition, cleaning and crushing them respectively to obtain coarse granules of the medicinal materials; adding water 8 to 10 times the weight of the raw materials to soak, decocting for 2 to 3 times, each time for 1.5 to 2 hours, combining the decoction liquid, concentrating to a clear paste with a relative density of 1.12 to 1.15, drying and crushing into fine powder at 130 to 160° C., sieving, adding an appropriate amount of excipients, mixing, making granules, and drying to obtain the granules; Or the drug preparation is a pill, and the preparation method comprises: taking the medicinal materials of Danshen, Angelica, Poria, Red Peony Root, Herba Polygoni Multiflori, Dipsacus Asper, Millettia Spatholobi, Herba Clematis, and Rhizoma Cyperi respectively according to the raw materials and weight ratio of the Chinese medicine composition, selecting them, and crushing them respectively to obtain coarse medicinal material particles; adding water 8 to 10 times the weight of the raw materials to soak, decocting for 2 to 3 times, each time for 1.5 to 2 hours, combining the decoctions, concentrating to a clear paste with a relative density of 1.12 to 1.15, drying and grinding them into fine powder at 130 to 160° C., sieving, adding an appropriate amount of excipients, mixing, making granules, drying, and then making water-honeyed pills to obtain the drug preparation; Or the drug preparation is a capsule, and the preparation method includes: taking Danshen, Angelica, Poria, Red Peony Root, Polygonum Multiflorum, Dipsacus Asper, Millettia Spatholobi, Herba Clematis, and Cyperus rotundus according to the raw materials and weight ratio of the traditional Chinese medicine composition, selecting, and coarsely crushing them to obtain coarse particles of the medicinal materials; soaking them in water 8 to 10 times the mass of the raw materials, decocting them for 2 to 3 times, each time for 1.5 to 2 hours, combining the decocted medicinal liquids, concentrating them to a clear paste with a relative density of 1.12 to 1.15, drying and crushing them into fine powder at 130 to 160°C, sieving, adding an appropriate amount of excipients, mixing them evenly, making them into granules, drying, and filling them into capsules.

8. The use according to claim 6, characterized in that: The pharmaceutical preparation is a decoction, and the preparation method comprises: taking the medicinal materials of salvia miltiorrhiza, angelica sinensis, poria cocos, red peony root, radix polygoni lobatae, dipsaci, millettia spatholobi, ophiopogonis, clematis root and rhizoma cyperi respectively according to the raw materials and weight ratio of the Chinese medicine composition, selecting them, and respectively coarsely crushing them to obtain coarse medicinal material particles; soaking them in water 3 to 10 times the mass of the raw materials for 60 minutes, then boiling them over high heat, then boiling them over low heat for 2 to 3 times, each time for 0.5 to 2 hours, combining the decoctions, concentrating them and keeping them warm at 40°C to obtain the decoction.

9. The use according to claim 8, characterized in that: The administration method of Chinese medicine wet hot compress is adopted, and the method of use includes: completely soaking the medical gauze in the decoction, exposing the affected limb, placing the medical gauze containing the medicine solution on the swollen part of the patient's upper limb and the corresponding acupoints respectively, wrapping the outer layer with a film for heat preservation, and the wet compress lasts for 10 to 20 minutes, once a day, wherein the acupoints include Jianyu point, Quchi point, Neiguan point, Hegu point and Fenglong point.

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