Traditional Chinese medicine composition for preventing and treating epidemic virus infection diseases, traditional Chinese medicine incense, traditional Chinese medicine sachet and preparation method

Abstract

The invention provides a traditional Chinese medicine composition for preventing and treating epidemic virus infection diseases, traditional Chinese medicine incense, a traditional Chinese medicine sachet and a preparation method, and can solve the problems that a mode of preventing and treating infectious respiratory diseases by oral taking of western medicines does not conform to clinical diagnosis and treatment specifications, the treatment effect is poor, the side effect is large, and the cost is high. The traditional Chinese medicine composition comprises the following raw material medicines in parts by weight: 8-15 parts of fingered citron, 2-4 parts of ephedra, 2-4 parts of asarum, 8-15 parts of platycodon grandiflorum, 6-12 parts of rhizoma kaempferiae, 6-12 parts of cardamom, 6-12 parts of clove, 6-12 parts of agilawood, 6-10 parts of cinnamon, 5-10 parts of borneol, 5-10 parts of menthol, 1-3 parts of pepper, 8-15 parts of elecampane, 6-12 parts of rosin and 6-10 parts of storax. The traditional Chinese medicine composition is prepared according to the addition and reduction of miasma-induced perinqing powder, has good effects of relieving exterior syndrome and expelling evil, reducing phlegm and opening orifices and the like, can be used for preventing and treating infectious respiratory diseases, and is remarkable in clinical curative effect, small in side effect and low in cost.

Description

Technical Field

[0001] The invention relates to a Chinese medicine composition, in particular to a Chinese medicine composition for preventing and treating epidemic viral infections, Chinese medicine fumigation incense, Chinese medicine sachet and a preparation method thereof. Background Art

[0002] Epidemic virus infections are highly contagious exogenous diseases that usually enter the body through the mouth and nose. They are characterized by rapid onset, severe condition, and rapid changes. If not treated in time or the treatment effect is poor, the condition will worsen and even develop into other diseases. Infectious respiratory diseases such as influenza A, influenza B, mycoplasma pneumonia, and new coronavirus infection all belong to the category of "epidemic virus" in traditional Chinese medicine. This type of disease has a high incidence rate and is highly contagious. It is a major public safety and health issue that threatens human health. At present, infectious respiratory diseases are mainly prevented and treated by oral Western medicine, and there is no specific medicine. However, due to objective factors such as drug indications, contraindications, and the patient's own economic conditions, the method of oral Western medicine for the prevention and treatment of infectious respiratory diseases does not meet the clinical diagnosis and treatment standards, and the treatment effect is poor, the side effects are large, and the cost is high. Therefore, finding new preventive measures is of great significance for the prevention and treatment of infectious respiratory diseases. Summary of the invention

[0003] The purpose of the present invention is to solve the technical problems that the method of preventing and treating infectious respiratory diseases by oral Western medicine does not conform to clinical diagnosis and treatment standards, has poor treatment effects, has large side effects and high costs, and to provide a Chinese medicine composition for preventing and treating epidemic viral infections, Chinese medicine incense, Chinese medicine sachets and preparation methods.

[0004] In order to achieve the above object, the present invention adopts the following technical solution:

[0005] A Chinese medicine composition for preventing and treating epidemic viral infections, which is special in that it comprises the following raw materials in parts by weight:

[0006] 8-15 parts of bergamot, 2-4 parts of ephedra, 2-4 parts of asarum, 8-15 parts of platycodon, 6-12 parts of galangal, 6-12 parts of cardamom, 6-12 parts of cloves, 6-12 parts of agarwood, 6-10 parts of cinnamon, 5-10 parts of borneol, 5-10 parts of menthol, 1-3 parts of zanthoxylum, 8-15 parts of costusroot, 6-12 parts of rosin, and 6-10 parts of styrax.

[0007] Furthermore, the weight parts of each raw material drug are:

[0008] 8-12 parts of bergamot, 2-4 parts of ephedra, 2-4 parts of asarum, 8-12 parts of platycodon, 6-10 parts of galangal, 6-10 parts of cardamom, 6-10 parts of cloves, 6-10 parts of agarwood, 6-8 parts of cinnamon, 5-8 parts of borneol, 5-8 parts of menthol, 1-3 parts of zanthoxylum, 8-12 parts of costusroot, 6-10 parts of rosin, and 6-8 parts of storax.

[0009] Furthermore, the weight parts of each raw material drug are:

[0010] 10 parts of bergamots, 3 parts of ephedra, 3 parts of asarum, 10 parts of platycodon, 8 parts of galangal, 8 parts of cardamoms, 8 parts of cloves, 8 parts of agarwood, 6 parts of cinnamon, 5 parts of borneol, 5 parts of menthol, 1 part of zanthoxylum bungeanum, 10 parts of costusroot, 8 parts of rosin, and 8 parts of styrax.

[0011] At the same time, the present invention also provides a Chinese medicinal incense prepared by using the above-mentioned Chinese medicinal composition for preventing and treating epidemic viral infections.

[0012] At the same time, the present invention also provides a Chinese medicine sachet prepared by using the above-mentioned Chinese medicine composition for preventing and treating epidemic viral infections.

[0013] At the same time, the present invention also provides a method for preparing the above-mentioned Chinese medicine sachet using the above-mentioned Chinese medicine composition for preventing and treating epidemic viral infections, which is special in that it comprises the following steps:

[0014] Step 1, grinding each weight portion of the raw material into coarse powder;

[0015] Step 2: Pack the coarse powder into sachets according to preset weights to prepare Chinese medicine sachets.

[0016] Furthermore, step 1 is specifically as follows: firstly, grinding each weight portion of the raw material drug except for styrax into coarse powder, and then adding 6 to 10 parts of styrax and mixing evenly;

[0017] Step 2 specifically includes packing the mixed raw materials into sachets according to preset weights to prepare Chinese medicine sachets.

[0018] Beneficial effects of the present invention:

[0019] 1. The present invention provides a kind of Chinese medicine composition for preventing and treating epidemic epidemic virus infection disease, wherein ephedra and asarum are monarch drugs, which can dispel wind and cold, dispel cold and relieve exterior symptoms, and promote lung function and dredge collaterals; platycodon and storax are assistant drugs, which can promote lung function and detoxify, and enhance the power of the whole prescription to dispel filth and evil, and promote qi circulation and relieve pain; bergamot, cardamom, galangal, clove, agarwood, cinnamon, prickly ash, costus root and rosin are adjuvant drugs, wherein bergamot, cardamom and galangal can soothe the liver and relieve depression, invigorate the spleen and dispel dampness, promote qi circulation and relieve pain, clove and agarwood are pungent and fragrant, promote meridians and collaterals, promote blood circulation and detoxify, cinnamon and prickly ash warm the yang and dredge collaterals, and expel evil to go out, costus root and rosin enhance the power of the whole prescription to soothe the liver and relieve depression, and promote collaterals and relieve pain; borneol and menthol are guiding drugs, which have the property of pungent and fragrant, can lead drugs into meridians, and at the same time, they are cool in nature, and can counter the pungent and dry nature of other drugs. This Chinese medicine composition is derived from Sun Simiao's Dumaofahhanqingsan with modifications. It has good effects of dispelling exterior pathogens, resolving phlegm and opening the orifices. It can be used to prevent and treat infectious respiratory diseases such as influenza, new coronavirus infection, chlamydial pneumonia, mycoplasma pneumonia, etc. It has significant clinical efficacy, few side effects and low cost.

[0020] 2. The present invention mainly uses aromatic drugs. Compared with the traditional oral Western medicine method, it does not need to be combined with oral drugs. The Chinese medicinal fragrance prepared by the combination can warm the middle and dispel evil. The effective ingredients enter the body through the human mouth and nose, which is the same as the path of the epidemic toxins entering the body through the mouth and nose. It increases the route of drug administration for prevention and treatment, greatly improves the patient's compliance, and has unique advantages such as high feasibility, small side effects, simple and cheap. The present invention is suitable for both healthy people and patients infected with epidemic toxins. When used for healthy people, it can play a good role in preventing epidemic toxins. When used for patients, it can effectively alleviate symptoms, shorten the healing time, and play a good therapeutic effect. DETAILED DESCRIPTION

[0021] Embodiment 1

[0022] A traditional Chinese medicine composition for preventing and treating epidemic viral infections, comprising 10g of bergamot, 10g of costusroot, 3g of ephedra, 3g of asarum, 10g of platycodon, 8g of galangal, 8g of cardamom, 8g of clove, 8g of agarwood, 8g of rosin, 6g of cinnamon, 5g of borneol, 5g of menthol, 1g of prickly ash, and 8g of storax.

[0023] The Chinese medicine sachet prepared from the above Chinese medicine composition comprises the following steps:

[0024] Step 1, weigh 10g of bergamot, 10g of costus root, 3g of ephedra, 3g of asarum, 10g of platycodon, 8g of galangal, 8g of cardamom, 8g of clove, 8g of agarwood, 8g of rosin, 6g of cinnamon, 5g of borneol, 5g of menthol, and 1g of zanthoxylum bungeanum, grind these raw materials into coarse powder, and then add 8g of storax to mix well;

[0025] Step 2: Pack the mixed API into sachets at a weight of 20 g per bag to prepare Chinese medicine sachets.

[0026] Embodiment 2

[0027] A traditional Chinese medicine composition for preventing and treating epidemic viral infections, comprising 15g of bergamot, 15g of costusroot, 3g of ephedra, 3g of asarum, 15g of platycodon, 12g of galangal, 12g of cardamom, 12g of clove, 12g of agarwood, 12g of rosin, 7g of cinnamon, 6g of borneol, 6g of menthol, 1g of prickly ash, and 8g of storax.

[0028] The Chinese medicine sachet prepared from the above Chinese medicine composition comprises the following steps:

[0029] Step 1, weigh 15g of bergamot, 15g of costusroot, 3g of ephedra, 3g of asarum, 15g of platycodon, 12g of galangal, 12g of cardamom, 12g of clove, 12g of agarwood, 12g of rosin, 7g of cinnamon, 6g of borneol, 6g of menthol, and 1g of zanthoxylum bungeanum, grind these raw materials into coarse powder, and then add 8g of storax to mix well;

[0030] Step 2: Pack the mixed API into sachets at a weight of 20 g per bag to prepare Chinese medicine sachets.

[0031] Embodiment 3

[0032] A traditional Chinese medicine composition for preventing and treating epidemic viral infections, comprising 8g of bergamot, 8g of costusroot, 2g of ephedra, 2g of asarum, 8g of platycodon, 6g of galangal, 6g of cardamom, 6g of clove, 6g of agarwood, 6g of rosin, 8g of cinnamon, 8g of borneol, 8g of menthol, 2g of prickly ash, and 6g of storax.

[0033] The Chinese medicine sachet prepared from the above Chinese medicine composition comprises the following steps:

[0034] Step 1, weigh 8g of bergamot, 8g of costus root, 2g of ephedra, 2g of asarum, 8g of platycodon, 6g of galangal, 6g of cardamom, 6g of clove, 6g of agarwood, 6g of rosin, 8g of cinnamon, 8g of borneol, 8g of menthol, and 2g of Zanthoxylum bungeanum, grind these raw materials into coarse powder, and then add 6g of storax to mix well;

[0035] Step 2: Pack the mixed API into sachets at a weight of 20 g per bag to prepare Chinese medicine sachets.

[0036] Embodiment 4

[0037] A traditional Chinese medicine composition for preventing and treating epidemic viral infections, comprising 12g of bergamot, 12g of costusroot, 4g of ephedra, 4g of asarum, 12g of platycodon, 10g of galangal, 10g of cardamom, 10g of clove, 10g of agarwood, 10g of rosin, 10g of cinnamon, 10g of borneol, 10g of menthol, 3g of zanthoxylum bungeanum and 7g of storax.

[0038] The Chinese medicine sachet prepared from the above Chinese medicine composition comprises the following steps:

[0039] Step 1, weigh 12g of bergamot, 12g of costusroot, 4g of ephedra, 4g of asarum, 12g of platycodon, 10g of galangal, 10g of cardamom, 10g of clove, 10g of agarwood, 10g of rosin, 10g of cinnamon, 10g of borneol, 10g of menthol, and 3g of Zanthoxylum bungeanum, grind these raw materials into coarse powder, and then add 7g of storax to mix well;

[0040] Step 2: Pack the mixed API into sachets at a weight of 20 g per bag to prepare Chinese medicine sachets.

[0041] Clinical Trial 1

[0042] 60 healthy volunteers were recruited from Xi'an Traditional Chinese Medicine Hospital and randomly divided into a prevention group and a blank group of 30 people each. They wore or did not wear the Chinese medicine sachets prepared in Example 1, and followed up for 3 months to compare the incidence of new coronavirus infection. The results showed that within 3 months, a total of 6 people in the prevention group were infected with the new coronavirus infection, with an infection rate of 20%, and a total of 14 people in the blank group were infected with the new coronavirus infection, with an infection rate of 46.67%. It can be seen that the present invention can effectively reduce the new coronavirus infection rate in healthy people.

[0043] Clinical Trial II

[0044] 60 patients infected with the new coronavirus were selected by Xi'an Traditional Chinese Medicine Hospital for systematic clinical observation. Diagnostic criteria: (1) The patient had no history of chronic bronchitis, bronchiectasis and other lung diseases; (2) had a history of contact with SARS-CoV-2 infected persons (positive nucleic acid test) within 14 days before the onset of the disease; (3) clinical symptoms were mainly fever and / or respiratory symptoms; (4) had imaging characteristics of new coronavirus infection; (5) nucleic acid test was positive; (6) the total number of peripheral blood leukocytes was normal or decreased, and the lymphocyte count was decreased. 60 patients were diagnosed with new coronavirus infection according to the above diagnostic criteria and were randomly divided into two groups after diagnosis, namely the treatment group and the control group. The control group was given conventional Western medicine treatment, and the treatment group wore the sachet prepared in Example 1 on the basis of conventional Western medicine treatment. The observation period was 20 days.

[0045] Usage: Wear the Chinese medicine sachet prepared in Example 1 in the chest pocket of your coat and replace it once every 3 to 4 days.

[0046] Efficacy evaluation criteria:

[0047] Recovery: Symptoms disappear, nucleic acid test is negative, blood count and imaging return to normal.

[0048] Markedly effective: Symptoms were relieved by more than 50%, and blood count and imaging were close to normal.

[0049] Improvement: Symptoms alleviated by more than 30%, blood count and imaging improved compared to before.

[0050] Ineffective: Symptoms, blood counts, and imaging studies did not improve significantly or worsened.

[0051] The clinical efficacy observation results of the control group and the treatment group are shown in Table 1:

[0052] Table 1

[0053]

[0054] It can be seen from Table 1 that the cure rate of the treatment group was 76.67%, the markedly effective rate was 13.33%, the improvement rate was 6.67%, and the ineffective rate was 3.33%. The above research results show that wearing the Chinese medicine sachet in Example 1 during the treatment of patients infected with the new coronavirus can improve the cure rate, alleviate symptoms, and shorten the course of the disease.

[0055] Clinical Trial 3

[0056] 60 patients with influenza A were selected by Xi'an Traditional Chinese Medicine Hospital for systematic clinical observation. Diagnostic criteria: (1) nucleic acid test is positive; (2) clinical symptoms are mainly fever and / or respiratory symptoms; (3) total peripheral blood leukocyte count is normal or decreased, and lymphocyte count is normal. 60 patients were diagnosed as influenza A patients according to the above diagnostic criteria and were randomly divided into two groups after diagnosis, namely the treatment group and the control group. The control group was given conventional Western medicine treatment, and the treatment group wore the Chinese medicine sachets prepared in Example 1 on the basis of conventional Western medicine treatment. The observation period was 15 days.

[0057] Usage: Wear the Chinese medicine sachet in Example 1 in the chest pocket of a coat and replace it once every 3 to 4 days.

[0058] Efficacy evaluation criteria:

[0059] Recovered: Symptoms disappear and nucleic acid test is negative.

[0060] Markedly effective: Symptoms alleviated by more than 50%.

[0061] Improvement: Symptoms alleviated by more than 30%.

[0062] Ineffective: Symptoms and nucleic acid levels did not improve significantly or worsened.

[0063] The clinical efficacy observation results of the control group and the treatment group are shown in Table 2:

[0064] Table 2

[0065]

[0066] As shown in Table 2, the cure rate of the treatment group was 63.33%, the marked efficacy rate was 30%, the improvement rate was 3.33%, and the ineffective rate was 3.33%. The above research results show that in the treatment of influenza A patients, wearing the Chinese medicine sachet in Example 1 can improve the cure rate, alleviate symptoms, and shorten the course of the disease.

[0067] Clinical Trial 4

[0068] 100 patients with mycoplasma pneumonia were selected by Xi'an Traditional Chinese Medicine Hospital for systematic clinical observation. Diagnostic criteria: (1) mainly respiratory symptoms such as dry cough and sore throat; (2) imaging meets the diagnostic criteria for mycoplasma pneumonia; (3) serum specific antibody test is positive. 100 patients were diagnosed with mycoplasma pneumonia according to the above diagnostic criteria and randomly divided into 2 groups, namely the treatment group and the control group. The control group was given conventional Western medicine treatment, and the treatment group wore the Chinese medicine sachets prepared in Example 1 on the basis of conventional Western medicine treatment. The observation period was 15 days.

[0069] Usage: Wear the Chinese medicine sachet in Example 1 in the chest pocket of a coat and replace it once every 3 to 4 days.

[0070] Efficacy evaluation criteria:

[0071] Recovery: Symptoms disappear, serum-specific antibody test is negative, and imaging manifestations completely disappear.

[0072] Markedly effective: Symptoms alleviated by more than 50%.

[0073] Improvement: Symptoms alleviated by more than 30%.

[0074] Ineffective: Symptoms and nucleic acid levels did not improve significantly or worsened.

[0075] The clinical efficacy observation results of the control group and the treatment group are shown in Table 3:

[0076] Table 3

[0077]

[0078] As shown in Table 3, the cure rate of the treatment group was 44%, the markedly effective rate was 34%, the improved rate was 20%, and the ineffective rate was 2%. The above research results show that in the treatment of mycoplasma pneumonia patients, wearing the Chinese medicine sachet in Example 1 can improve the cure rate, alleviate symptoms, and shorten the course of the disease.

[0079] Clinical Trial 5

[0080] 100 patients with influenza B were selected by Xi'an Traditional Chinese Medicine Hospital for systematic clinical observation. Diagnostic criteria: (1) Symptoms such as fever, headache, myalgia and general discomfort, with body temperature up to 39-40°C; (2) nucleic acid test was positive. The 100 patients with influenza B were randomly divided into 2 groups, namely the treatment group and the control group. The control group was given conventional Western medicine treatment, and the treatment group wore the Chinese medicine sachets prepared in Example 2 on the basis of conventional Western medicine treatment. The observation period was 15 days.

[0081] Usage: Wear the Chinese medicine sachet in Example 2 in the chest pocket of your coat and replace it once every 3 to 4 days.

[0082] Efficacy evaluation criteria:

[0083] Recovered: Symptoms disappear and nucleic acid test is negative.

[0084] Markedly effective: Symptoms alleviated by more than 50%.

[0085] Improvement: Symptoms alleviated by more than 30%.

[0086] Ineffective: Symptoms and nucleic acid levels did not improve significantly or worsened.

[0087] The clinical efficacy observation results of the control group and the treatment group are shown in Table 4:

[0088] Table 4

[0089]

[0090] As shown in Table 4, the cure rate of the treatment group was 60%, the markedly effective rate was 20%, the improved rate was 16%, and the ineffective rate was 4%. The results show that the present invention has the advantages of rapid onset, low side effects, and high efficiency in treating patients with influenza B. In addition, the present invention can also effectively improve the symptoms of fever, muscle aches, cough and sputum in patients with influenza B.

[0091] The above is only a specific embodiment of the present invention, but the protection scope of the present invention is not limited thereto. Any changes or substitutions within the technical scope disclosed by the present invention should be included in the protection scope of the present invention. Therefore, the protection scope of the present invention should be based on the protection scope of the claims.

Claims

1. A Chinese medicine composition for preventing and treating epidemic viral infections, characterized in that: The raw materials include the following parts by weight: 8-15 parts of bergamot, 2-4 parts of ephedra, 2-4 parts of asarum, 8-15 parts of platycodon, 6-12 parts of galangal, 6-12 parts of cardamom, 6-12 parts of cloves, 6-12 parts of agarwood, 6-10 parts of cinnamon, 5-10 parts of borneol, 5-10 parts of menthol, 1-3 parts of zanthoxylum, 8-15 parts of costusroot, 6-12 parts of rosin, and 6-10 parts of styrax.

2. The Chinese medicine composition for preventing and treating epidemic viral infections according to claim 1, characterized in that: The weight parts of each raw material are: 8-12 parts of bergamot, 2-4 parts of ephedra, 2-4 parts of asarum, 8-12 parts of platycodon, 6-10 parts of galangal, 6-10 parts of cardamom, 6-10 parts of cloves, 6-10 parts of agarwood, 6-8 parts of cinnamon, 5-8 parts of borneol, 5-8 parts of menthol, 1-3 parts of zanthoxylum, 8-12 parts of costusroot, 6-10 parts of rosin, and 6-8 parts of storax.

3. The Chinese medicine composition for preventing and treating epidemic viral infections according to claim 2, characterized in that: The weight parts of each raw material are: 10 parts of bergamots, 3 parts of ephedra, 3 parts of asarum, 10 parts of platycodon, 8 parts of galangal, 8 parts of cardamoms, 8 parts of cloves, 8 parts of agarwood, 6 parts of cinnamon, 5 parts of borneol, 5 parts of menthol, 1 part of zanthoxylum bungeanum, 10 parts of costusroot, 8 parts of rosin, and 8 parts of styrax.

4. A Chinese medicinal incense prepared using the Chinese medicinal composition for preventing and treating epidemic viral infections as described in any one of claims 1 to 3.

5. A Chinese medicine sachet prepared using the Chinese medicine composition for preventing and treating epidemic viral infections as described in any one of claims 1 to 3.

6. A method for preparing the Chinese medicine sachet according to claim 5 using the Chinese medicine composition for preventing and treating epidemic viral infections according to any one of claims 1 to 3, characterized in that: The following steps are involved: Step 1, grinding each weight portion of the raw material into coarse powder; Step 2: Pack the coarse powder into sachets according to preset weights to prepare Chinese medicine sachets.

7. The method for preparing a sachet according to claim 6, characterized in that: Step 1 is specifically as follows: firstly, grinding each weight portion of the raw materials except for styrax into coarse powder, and then adding 6 to 10 parts of styrax and mixing evenly; Step 2 specifically includes packing the mixed raw materials into sachets according to preset weights to prepare Chinese medicine sachets.

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