Protein nanoparticle for treating ulcerative colitis as well as preparation method and application thereof

By preparing protein nanoparticles loaded with 5-aminosalicylic acid and combining with stabilizers of mannose grafted hyaluronic acid, the problem that existing drugs are difficult to target the inflammatory site of the colon is solved, and more efficient anti-inflammatory and intestinal barrier repair effects are achieved.

CN119679961APending Publication Date: 2025-03-25CHINA PHARM UNIV
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Patent Information

Application Number
CN202411587941.X
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-11-08
Publication Date
2025-03-25

AI Technical Summary

Technical Problem

The existing drugs for treating ulcerative colitis are difficult to effectively target the inflammatory site of the colon, resulting in poor treatment effect and toxic and side effects.

Method used

Targeted protein nanoparticles are prepared by preparing 5-aminosalicylic acid-loaded protein nanoparticles and combining a stabilizer of mannose grafted hyaluronic acid with it. The nanoparticles are prepared by anti-solvent method and physically cross-linked by electrostatic adsorption, improving the targeting and stability of the drug.

Benefits of technology

Targeted delivery of 5-aminosalicylic acid in the body is achieved, improving the aggregation and retention time of the drug in the inflammatory site of the colon, enhancing the effects of anti-inflammatory, antioxidant and intestinal epithelial barrier repair, and reducing toxic and side effects.

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Abstract

The invention relates to protein nanoparticles for treating ulcerative colitis as well as a preparation method and application thereof, and relates to the field of nano pharmaceutical preparations. 5-aminosalicylic acid is encapsulated in zein to achieve the purpose of improving the bioavailability of the 5-aminosalicylic acid by preparing protein nanoparticles of a targeted inflammation colon part, mannose grafted hyaluronic acid is used as a stabilizer to be attached to the surfaces of the zein nanoparticles through electrostatic adsorption and hydrogen-bond interaction, and the bioavailability of the 5-aminosalicylic acid is improved. Mannose can be targeted to immune cells through a mannose receptor, and can be cooperated with 5-aminosalicylic acid to treat ulcerative colitis. The hyaluronic acid has the effects of stabilizing the protein nanoparticles and targeting macrophages and intestinal epithelial cell CD44 receptors in ulcerative colitis tissues, so that aggregation of the nanoparticles in the colitis tissues is mediated, the protein nanoparticles have the functions of resisting inflammation, resisting oxidation and repairing barrier injury, and a new research direction is provided for treatment of ulcerative colitis.
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