Ebbuselenium derivative, pharmaceutical composition and application of ebbuselenium derivative

By developing an ebuseselen derivative that can inhibit the activity of Pseudomonas aeruginosa polyphosphate kinases (PPKs), the problem of difficult inhibition of bacterial survival and pathogenicity in the prior art is solved, and the effect of reducing biofilm formation and enhancing antibiotic sensitivity is achieved.

CN119684232AActive Publication Date: 2025-03-25CENT SOUTH UNIV
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Patent Information

Application Number
CN202411886579.6
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-12-20
Publication Date
2025-03-25
Estimated Expiration
2044-12-20

AI Technical Summary

Technical Problem

The prior art is difficult to effectively inhibit the activity of polyphosphate kinases (PPKs) of Pseudomonas aeruginosa, resulting in bacteria remaining survivable and pathogenic under antibiotic pressure.

Method used

Developing an ebuse selenyl derivative can effectively inhibit PPKs activity, reduce the polyphosphate level of bacteria, reduce the formation of biofilms, reduce the motility of bacteria, reduce the production of virulence factors, and enhance the sensitivity of bacteria to antibiotics.

Benefits of technology

By inhibiting the activity of PPKs, ebuse selenyl derivatives can significantly reduce the pathogenicity of Pseudomonas aeruginosa, reduce biofilm formation and virulence factor production, enhance bacterial sensitivity to antibiotics, thereby effectively preventing and treating bacterial infections.

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Abstract

The invention discloses an ebbuselenium derivative, a pharmaceutical composition and application of the ebbuselenium derivative. The ebbeselenium derivative provided by the invention has the characteristic of inhibiting PPK activity, reduces the polyphosphoric acid (polyP) level of bacteria, reduces the formation of biological membranes, reduces the athletic ability of the bacteria, reduces the generation of virulence factors, can also enhance the sensitivity of the bacteria to antibiotics, and can be used for preparing a medicine for preventing and treating the diseases, such as the diseases, the pests and the like. Therefore, the compound is used for preventing and treating bacterial infection diseases.
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