Slow-release nicotine buccal product and preparation method thereof

Abstract

The invention discloses a sustained-release nicotine buccal product and a preparation method thereof, the sustained-release nicotine buccal product comprises the following preparation raw materials: a microcapsule, a sustained-release auxiliary agent and a functional auxiliary agent, nicotine / salt and essence are embedded in the microcapsule, and the sustained-release auxiliary agent is a water-soluble polyhydroxy compound. The water-soluble polyhydroxy compound is used as the slow-release auxiliary agent, so that the loss rate of nicotine in the microcapsule can be greatly reduced, the release of nicotine in the use process is more lasting and uniform, meanwhile, the humidity of the product can be improved, the smoke is softer, the discomfort of the throat is reduced, and the smoking experience of a user is improved; besides, the humidity is improved, so that the release of nicotine can be promoted, the nicotine can be absorbed more easily, the stability of the nicotine can be improved, and the storage time of the product is prolonged.

Description

Technical Field

[0001] The present invention relates to the technical field related to oral products, and in particular to a sustained-release nicotine oral product and a preparation method thereof. Background Art

[0002] Smoke-free has become a global goal, and countries are adopting different strategies to achieve this goal. Smokeless tobacco products, as the only tobacco products that can be used in any public place, are a strong alternative to traditional cigarettes. Smokeless nicotine products are mainly divided into snuff, oral tobacco, chewing tobacco and other products. Currently, sales in many countries are gradually increasing. Among them, oral nicotine products have a lower content of N-nitrosamines (TSNAs) than traditional cigarettes, and are far less harmful than traditional cigarettes. Oral nicotine products are mainly sold in foreign markets and are mainly divided into American moist snuff, American dry snuff, Swedish moist snuff and throat lozenge-type snuff, which are mostly in the form of bags, while domestic smokeless nicotine products are still in their infancy.

[0003] When using oral nicotine products on the market, there is a strong sense of nicotine stimulation at the beginning of use. As the time in the mouth increases, the nicotine content decreases sharply in the later stage, and the aroma becomes lighter, similar to chewing gum becoming tasteless and intangible. These phenomena will affect the experience and increase the interest of novices in using oral products, thereby slowing down the progress of smoke-free.

[0004] Therefore, the development of oral nicotine products that continuously release flavors and nicotine salts is of great significance to improving user experience and further promoting the smoke-free process. Summary of the invention

[0005] The present invention aims to solve at least one of the technical problems existing in the prior art. To this end, the present invention provides a sustained-release nicotine oral product, which can release nicotine and flavors in a long-lasting and uniform manner and can also better maintain relative humidity.

[0006] The present invention also provides a method for preparing the sustained-release nicotine oral product.

[0007] According to one aspect of the present invention, a sustained-release nicotine oral product is provided, comprising the following preparation raw materials: microcapsules, sustained-release aids and functional aids, wherein nicotine / salts (i.e., nicotine and / or nicotine salts) and flavors are embedded in the microcapsules, the sustained-release aid is at least one of propylene glycol, glycerol, and polyethylene glycol, and the mass proportion of the sustained-release aid in the preparation raw materials is 0.64-5.8%.

[0008] According to a preferred embodiment of the present invention, at least the following beneficial effects are achieved: in view of the defect that the effective ingredients such as nicotine and aroma in the current oral nicotine products are released quickly, the present invention embeds nicotine or nicotine salt and flavor in the wall material in the form of microcapsules, which can achieve the effect of continuously releasing flavor and nicotine / salt and reducing irritation; using water-soluble polyhydroxy compounds as sustained-release aids can greatly reduce the decay rate of the effective ingredients in the microcapsules, so that the release of the effective ingredients during use is more durable and uniform, and at the same time, the sustained-release aid further locks in water by forming molecular bonds with water-insoluble cellulose derivatives, maintains the humidity of the product, releases nicotine evenly, reduces throat discomfort, and improves the user's smoking experience; in addition, the increase in humidity can not only promote the release of nicotine during use, making it easier to be absorbed, but also improve the stability of nicotine and extend the storage time of the product.

[0009] In some preferred embodiments of the present invention, the water-soluble polyhydroxy compound is a polar water-soluble polyhydroxy compound.

[0010] In some more preferred embodiments of the present invention, the water-soluble polyol comprises at least one of propylene glycol, glycerol, and polyethylene glycol. The polyol contains multiple hydroxyl functional groups (-OH), which can form hydrogen bonds with water molecules, thereby making the polyol hygroscopic; polar polyols such as propylene glycol, glycerol, and polyethylene glycol have stronger hygroscopicity than non-polar polyols, thus having better sustained-release effect.

[0011] In some preferred embodiments of the present invention, the cellulose ether derivative contains ethoxy groups.

[0012] In some more preferred embodiments of the present invention, the cellulose ether derivative is ethyl cellulose. Ethyl cellulose reacts with the alcoholic hydroxyl group in the water-soluble polyhydroxy compound, so that the two substances cooperate with each other, thereby better controlling the sustained release rate of the microcapsule.

[0013] In some preferred embodiments of the present invention, the nicotine salt is any one of benzoate, lactate, and salicylate.

[0014] In some preferred embodiments of the present invention, the mass ratio of the cellulose ether derivative to the water-soluble polyhydroxy compound is 3:10-7:1.

[0015] In some preferred embodiments of the present invention, the embedding rate of the microcapsules is between 18% and 24%.

[0016] In some embodiments of the present invention, the functional auxiliary agent includes at least one of a filler, a preservative, a flavoring agent and a sweetener.

[0017] In some embodiments of the present invention, the filler is at least one of modified starch, microcrystalline cellulose, corn starch, and carboxymethyl cellulose.

[0018] In some embodiments of the present invention, the sweetener is at least one of erythritol, mogroside, stevioside, neotame, trehalose, honey, and glucose.

[0019] In some embodiments of the present invention, the flavoring agent may be the same as or different from the flavor embedded in the microcapsule.

[0020] In some preferred embodiments of the present invention, the flavor is any edible oil-soluble flavor.

[0021] In some embodiments of the present invention, the sustained-release nicotine oral product comprises the following raw materials in parts by weight:

[0022]

[0023]

[0024] The proportion of flavoring agents in the above ratio does not include the flavor embedded in the microcapsule.

[0025] In some preferred embodiments of the present invention, all raw materials in the preparation raw materials are food grade.

[0026] In some preferred embodiments of the present invention, the sustained-release nicotine oral product is a nicotine bag, which can be prepared into a nicotine bag or other forms, which can be selected according to needs.

[0027] According to another aspect of the present invention, a method for preparing a sustained-release nicotine oral product is provided, wherein the raw materials for preparing the sustained-release nicotine oral product include a filler, a preservative, a microcapsule, a flavoring agent, a sustained-release aid, a sweetener, and water, wherein the sustained-release aid is at least one of propylene glycol, glycerol, and polyethylene glycol; the preparation method comprises the following steps:

[0028] S1, mixing a filler, a preservative and microcapsules to obtain a mixture I;

[0029] S2, mixing the flavoring agent, the sustained-release aid and the sweetener and adding them to the mixture I;

[0030] S3. Adjust the moisture content to obtain.

[0031] According to a preferred embodiment of the present invention, the preparation method has at least the following beneficial effects: the preparation method of the present invention can be simply mixed and is easy to operate. The solid substance and the liquid substance are mixed separately, and then the solid mixture and the liquid mixture are mixed to better ensure the uniformity of each substance.

[0032] In some embodiments of the present invention, step S1 further includes a microcapsule preparation process, specifically including:

[0033] Ethyl cellulose, nicotine / salt and flavor are added to an organic solvent, and then added to an aqueous solution containing a nonionic surfactant or an organic solvent-water mixture to prepare an emulsion, and freeze-dried to obtain the product. The microcapsule preparation process of the scheme of the present invention is simple and has strong repeatability. By preparing microcapsules containing nicotine salt and flavor, and adding them to nicotine oral products, the effect of slowly releasing flavor and nicotine is achieved, which solves the problem of short-term nicotine release and serious flavor loss during the use of nicotine bags.

[0034] In some preferred embodiments of the present invention, the nonionic surfactant includes at least one of Tween-80, Tween-20 or Span-60.

[0035] In some preferred embodiments of the present invention, the organic solvent includes at least one of ethyl acetate, alcohol solvents, dichloromethane, and aromatic hydrocarbon solvents.

[0036] In some preferred embodiments of the present invention, the alcohol solvent is selected from at least one of methanol and ethanol.

[0037] In some embodiments of the present invention, the moisture content is adjusted to 10-40% in step S3. The moisture content of the sustained-release nicotine oral product is controlled within this range so that the nicotine in the oral product is released at a stable rate. At the same time, precise control of the moisture content can ensure that the quality and performance of each product meet the expected standards and reduce the difference between batches.

[0038] Other features and advantages of the present invention will be set forth in the description which follows, and in part will be apparent from the description, or may be learned by practice of the present invention. BRIEF DESCRIPTION OF THE DRAWINGS

[0039] The above and / or additional aspects and advantages of the present invention will become apparent and easily understood from the description of the embodiments in conjunction with the following drawings, in which:

[0040] Figure 1 is a simulated nicotine release curve diagram of the nicotine bags prepared in Examples 1 to 5 of the present invention;

[0041] Figure 2 It is a simulated nicotine release curve diagram of the nicotine bags prepared in Example 1 of the present invention and Comparative Example 1;

[0042] Figure 3 It is a simulated nicotine release curve diagram of the nicotine bags prepared in Example 1 of the present invention and Comparative Example 3. DETAILED DESCRIPTION

[0043] The following will be combined with the embodiments to clearly and completely describe the concept of the present invention and the technical effects produced, so as to fully understand the purpose, characteristics and effects of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all of them. Based on the embodiments of the present invention, other embodiments obtained by technicians in this field without creative work are all within the scope of protection of the present invention. The test methods used in the embodiments are conventional methods unless otherwise specified; the materials, reagents, etc. used, unless otherwise specified, can be reagents and materials obtained from commercial channels. Unless otherwise specified, the same parameter in each embodiment has the same value. The embodiments described below are exemplary and are only used to explain the present invention, and cannot be understood as limitations on the present invention.

[0044] The "room temperature" referred to in the present invention refers to 25±5°C, and is specifically 25°C in the embodiments.

[0045] The preparation process of the microcapsules used in the following Examples 1 to 8 and Comparative Example 1 is as follows: 12 parts of ethyl cellulose, 3 parts of nicotine benzoate salt and 3 parts of lemon flavor (which may also be replaced by any other oil-soluble flavor) are added to 90 parts of ethyl acetate (60-120 parts are acceptable), stirred to make them uniformly dissolved, and the above solution is slowly added dropwise (using a peristaltic pump to add at a speed of 1.5 ml / min, and the adding speed may be between 0.5-3 ml / min) to 80 parts (50-100 parts are acceptable) of Tween 80 (the weight of Tween 80 is 10 parts) of saturated ethyl acetate aqueous solution (saturated solution at room temperature) using a peristaltic pump, stirred uniformly, and stirred at 100 00rpm (8000-15000rpm) high-speed shearing machine is used for homogenization to obtain an emulsion. After the emulsion is freeze-dried for 24h, microcapsules embedded with nicotine salt and flavor are obtained (the embedding rate of microcapsules prepared by this method is usually between 18-24%; the specific test result of this test is 22%. Test method: The embedding rate of the microcapsules is determined by thermal stability analysis (TGA). 3-5mg of the freeze-dried microcapsules are placed on the tray of TGA5500 analyzer, and the temperature is increased from 30°C to 600°C in nitrogen at a heating rate of 10°C. The heating curve is recorded, and the embedding rate of the microcapsules is determined according to the start of weight loss and the relative temperature peak).

[0046] The preparation process of the microcapsules used in Example 9 is as follows: the only difference between the microcapsules used in Examples 1 to 8 and Comparative Example 1 is that ethyl acetate is replaced by methanol, and an equal amount of a saturated ethyl acetate aqueous solution containing Tween-80 is replaced by an equal amount of an aqueous solution containing Tween-80.

[0047] The raw materials and amounts of the nicotine salt-flavor mixture used in Comparative Example 2 are the same as those of the microcapsules used in Examples 1 to 8 and Comparative Example 1, with the only difference being that the preparation process is as follows: ethyl cellulose, nicotine salt and flavor are mixed and added to ethyl acetate, and a saturated ethyl acetate aqueous solution containing Tween 80 is added (directly added), and stirred evenly to obtain the mixture.

[0048] Example 1

[0049] This embodiment prepares a sustained-release nicotine bag, and the specific process is as follows:

[0050] (1) 10 parts of modified starch, 30 parts of microcrystalline cellulose, 4 parts of carboxymethyl cellulose, 0.5 parts of potassium sorbate, and 1.5 parts of microcapsules are uniformly mixed in a weight ratio to obtain a powdery mixture;

[0051] (2) mixing 2 parts of lemon essence, 2 parts of propylene glycol, 3 parts of erythritol and 1 part of mogroside into the mixed powder of (1);

[0052] (3) adjusting the moisture content of the mixed powder to 10 parts;

[0053] (4) uniformly stirring the mixture after adjusting the water content;

[0054] (5) The uniformly stirred mixture in (4) is packaged with edible filter paper at a specification of 0.3 g / bag and sterilized by ultraviolet light.

[0055] Example 2

[0056] This embodiment prepares a sustained-release nicotine bag, and the specific process is as follows:

[0057] (1) 5 parts of modified starch, 40 parts of microcrystalline cellulose, 3 parts of corn starch, 1 part of potassium sorbate, and 3.5 parts of microcapsules are uniformly mixed in a weight ratio to obtain a powdery mixture;

[0058] (2) 2 parts of lemon flavor, 2 parts of polyethylene glycol, 2 parts of stevioside, 0.5 parts of neotame, and 1.5 parts of mogroside were mixed and added to the mixed powder of (1);

[0059] (3) adjusting the moisture content of the mixed powder to 25 parts;

[0060] (4) uniformly stirring the mixture after adjusting the water content;

[0061] (5) The uniformly stirred mixture in (4) is packaged with edible filter paper at a specification of 0.3 g / bag and sterilized by ultraviolet light.

[0062] Example 3

[0063] This embodiment prepares a sustained-release nicotine bag, and the specific process is as follows:

[0064] (1) 40 parts of modified starch, 5 parts of carboxymethyl cellulose, 1 part of potassium sorbate, and 3 parts of microcapsules are uniformly mixed according to weight to obtain a powdery mixture;

[0065] (2) Mix 3 parts of lemon essence, 2 parts of propylene glycol, 0.5 parts of neotame, 1 part of trehalose, 3 parts of honey, and 2.5 parts of glucose and add them to the mixed powder of (1);

[0066] (3) adjusting the moisture content of the mixed powder to 10 parts;

[0067] (4) uniformly stirring the mixture after adjusting the water content;

[0068] (5) The uniformly stirred mixture in (4) is packaged with edible filter paper at a specification of 0.3 g / bag and sterilized by ultraviolet light.

[0069] Example 4

[0070] This embodiment prepares a sustained-release nicotine bag, and the specific process is as follows:

[0071] (1) 40 parts of microcrystalline cellulose, 0.6 parts of potassium sorbate, and 2.5 parts of microcapsules are uniformly mixed in a weight ratio to obtain a powdery mixture;

[0072] (2) 4 parts of lemon essence, 3 parts of propylene glycol, 3 parts of honey, 1 part of erythritol, 1.5 parts of mogroside, and 0.5 parts of neotame are mixed and added to the mixed powder of (1);

[0073] (3) adjusting the moisture content of the mixed powder to 20 parts;

[0074] (4) uniformly stirring the mixture after adjusting the water content;

[0075] (5) The uniformly stirred mixture in (4) is packaged with edible filter paper at a specification of 0.3 g / bag and sterilized with ultraviolet light;

[0076] (6) Place the nicotine bag in artificial saliva and take samples every 5 minutes for ultraviolet spectrophotometry testing to measure the nicotine release within 30 minutes.

[0077] Example 5

[0078] This embodiment prepares a sustained-release nicotine bag, and the specific process is as follows:

[0079] (1) 20 parts of microcrystalline cellulose, 10 parts of modified starch, 1 part of potassium sorbate, and 3 parts of microcapsules are uniformly mixed according to weight to obtain a powdery mixture;

[0080] (2) Mix 2 parts of lemon essence, 4 parts of polyethylene glycol, 2 parts of stevioside, 2 parts of erythritol, and 1 part of honey and add them to the mixed powder of (1);

[0081] (3) adjusting the moisture content of the mixed powder to 24 parts;

[0082] (4) uniformly stirring the mixture after adjusting the water content;

[0083] (5) The uniformly stirred mixture in (4) is packaged with edible filter paper at a specification of 0.3 g / bag and sterilized by ultraviolet light.

[0084] Example 6

[0085] This embodiment prepares a sustained-release nicotine bag, and the specific process is as follows:

[0086] (1) 10 parts of modified starch, 30 parts of microcrystalline cellulose, 4 parts of carboxymethyl cellulose, 0.5 parts of potassium sorbate, and 1.5 parts of microcapsules are uniformly mixed in a weight ratio to obtain a powdery mixture;

[0087] (2) 2 parts of lemon essence, 0.4 parts of propylene glycol, 3 parts of erythritol and 1 part of mogroside are mixed and added to the mixed powder of (1);

[0088] (3) adjusting the moisture content of the mixed powder to 10 parts;

[0089] (4) uniformly stirring the mixture after adjusting the water content;

[0090] (5) The uniformly stirred mixture in (4) is packaged with edible filter paper at a specification of 0.3 g / bag and sterilized by ultraviolet light.

[0091] Example 7

[0092] This embodiment prepares a sustained-release nicotine bag, and the specific process is as follows:

[0093] (1) 10 parts of modified starch, 30 parts of microcrystalline cellulose, 4 parts of carboxymethyl cellulose, 0.5 parts of potassium sorbate, and 1.5 parts of microcapsules are uniformly mixed in a weight ratio to obtain a powdery mixture;

[0094] (2) mixing 2 parts of lemon essence, 1 part of propylene glycol and 1 part of polyethylene glycol, 3 parts of erythritol and 1 part of mogroside into the mixed powder of (1);

[0095] (3) adjusting the moisture content of the mixed powder to 10 parts;

[0096] (4) uniformly stirring the mixture after adjusting the water content;

[0097] (5) The uniformly stirred mixture in (4) is packaged with edible filter paper at a specification of 0.3 g / bag and sterilized by ultraviolet light.

[0098] Example 8

[0099] This embodiment prepares a sustained-release nicotine bag, and the specific process is as follows:

[0100] (1) 10 parts of modified starch, 30 parts of microcrystalline cellulose, 4 parts of carboxymethyl cellulose, 0.5 parts of potassium sorbate, and 1.5 parts of microcapsules are uniformly mixed in a weight ratio to obtain a powdery mixture;

[0101] (2) mixing 2 parts of lemon essence, 2 parts of glycerin, 3 parts of erythritol and 1 part of mogroside into the mixed powder of (1);

[0102] (3) adjusting the moisture content of the mixed powder to 10 parts;

[0103] (4) uniformly stirring the mixture after adjusting the water content;

[0104] (5) The uniformly stirred mixture in (4) is packaged with edible filter paper at a specification of 0.3 g / bag and sterilized by ultraviolet light.

[0105] Example 9

[0106] This embodiment prepares a sustained-release nicotine bag, and the specific process is as follows:

[0107] (1) 10 parts of modified starch, 30 parts of microcrystalline cellulose, 4 parts of carboxymethyl cellulose, 0.5 parts of potassium sorbate, and 1.5 parts of microcapsules are uniformly mixed in a weight ratio to obtain a powdery mixture;

[0108] (2) mixing 2 parts of lemon essence, 2 parts of propylene glycol, 3 parts of erythritol and 1 part of mogroside into the mixed powder of (1);

[0109] (3) adjusting the moisture content of the mixed powder to 10 parts;

[0110] (4) uniformly stirring the mixture after adjusting the water content;

[0111] (5) The uniformly stirred mixture in (4) is packaged with edible filter paper at a specification of 0.3 g / bag and sterilized by ultraviolet light.

[0112] Comparative Example 1

[0113] This comparative example prepares a sustained-release nicotine bag, and the specific process is as follows:

[0114] (1) 10 parts of modified starch, 30 parts of microcrystalline cellulose, 4 parts of carboxymethyl cellulose, 0.5 parts of potassium sorbate, and 1.5 parts of microcapsules are uniformly mixed in a weight ratio to obtain a powdery mixture;

[0115] (2) 2 parts of lemon essence, 2 parts of emulsified corn oil, 3 parts of erythritol and 1 part of mogroside are mixed and added to the mixed powder of (1);

[0116] (3) adjusting the moisture content of the mixed powder to 10 parts;

[0117] (4) uniformly stirring the mixture after adjusting the water content;

[0118] (5) The uniformly stirred mixture in (4) is packaged with edible filter paper at a specification of 0.3 g / bag and sterilized by ultraviolet light.

[0119] Comparative Example 2

[0120] This comparative example prepares a sustained-release nicotine bag, and the specific process is as follows:

[0121] (1) 10 parts of modified starch, 30 parts of microcrystalline cellulose, 4 parts of carboxymethyl cellulose, 0.5 parts of potassium sorbate, and 1.5 parts of nicotine salt-flavor mixture are uniformly mixed according to weight to obtain a powdery mixture;

[0122] (2) mixing 2 parts of lemon essence, 2 parts of propylene glycol, 3 parts of erythritol and 1 part of mogroside into the mixed powder of (1);

[0123] (3) adjusting the moisture content of the mixed powder to 10 parts;

[0124] (4) uniformly stirring the mixture after adjusting the water content;

[0125] (5) The uniformly stirred mixture in (4) is packaged with edible filter paper at a specification of 0.3 g / bag and sterilized by ultraviolet light.

[0126] Comparative Example 3

[0127] This comparative example prepares a sustained-release nicotine bag, and the specific process is as follows:

[0128] (1) 10 parts of modified starch, 30 parts of microcrystalline cellulose, 4 parts of carboxymethyl cellulose, 0.5 parts of potassium sorbate, and 1.5 parts of microcapsules are uniformly mixed in a weight ratio to obtain a powdery mixture;

[0129] (2) 2 parts of lemon essence, 0.1 parts of propylene glycol, 3 parts of erythritol and 1 part of mogroside are mixed and added to the mixed powder of (1);

[0130] (3) adjusting the moisture content of the mixed powder to 10 parts;

[0131] (4) uniformly stirring the mixture after adjusting the water content;

[0132] (5) The uniformly stirred mixture in (4) is packaged with edible filter paper at a specification of 0.3 g / bag and sterilized by ultraviolet light.

[0133] The formulas of various embodiments and comparative examples are summarized in Table 1 below:

[0134] Table 1

[0135]

[0136]

[0137] Test example

[0138] This test example tests the nicotine sustained-release performance of the sustained-release nicotine pouches prepared in the examples and comparative examples. The test process is as follows:

[0139] The nicotine bag was placed in artificial saliva, and samples were taken every 5 minutes for UV spectrophotometer testing to determine the nicotine release rate within 30 minutes.

[0140] The test results of Examples 1 to 5 are as follows Figure 1 As shown, the test results of Example 1 and Comparative Example 1 are compared. Figure 2 As shown. Figure 1 and 2 It can be seen that the nicotine bag prepared by the embodiment of the present invention can release nicotine slowly, persistently and evenly, while in comparative example 1, when the sustained-release aid of the present invention is replaced with the sustained-release aid emulsified corn oil commonly used in this field, the release rate fluctuation of the prepared nicotine bag is significantly greater than that of the embodiment of the present invention. At the same time, the release time only lasts for 20 minutes and the release rate is below 90%, while the release time of the present invention can last for more than 30 minutes, the release amount is more than 90%, the duration is increased by at least 50%, and the release amount is also increased. This shows that the sustained-release aid of the present invention generates a molecular bond with the water-insoluble cellulose derivative, further locks water, maintains the humidity of the product, releases nicotine evenly, delays the nicotine loss rate in the microcapsule, and can also make the release of nicotine more durable and uniform during use.

[0141] The effects of Examples 7 to 9 are comparable to those of Example 1, and the effect of Example 6 is weaker than that of Example 1, but still has good release stability.

[0142] In Comparative Example 2, since the nicotine salt and the flavor are simply mixed without being embedded, the nicotine salt is released quickly and short-actingly during use and has a strong irritation.

[0143] The test results of Example 1 and Comparative Example 3 are compared. Figure 3 As shown in the figure, it can be seen that when the amount of the sustained-release aid added is too small, the stability of nicotine release will be affected.

[0144] In summary, the oral product prepared by the scheme of the present invention is a nicotine oral product that can provide continuous satisfaction and aroma release. In view of the fact that the current nicotine oral products are highly irritating, release nicotine quickly, and lose aroma seriously during use, the present invention embeds nicotine salts and flavors in the wall material to achieve the effect of slowly releasing flavors and nicotine, providing long-lasting aroma and long-lasting satisfaction. At the same time, a specific sustained-release adjuvant is used to make the nicotine release lasting and uniform during use, with a higher release rate, softer smoke, and a better overall smoking experience.

[0145] The embodiments of the present invention are described in detail above, but the present invention is not limited to the above embodiments. Various changes can be made within the knowledge scope of ordinary technicians in the relevant technical field without departing from the purpose of the present invention.

Claims

1. A sustained-release nicotine oral product, characterized in that: The preparation raw materials include: microcapsules, sustained-release aids and functional aids, wherein nicotine / salt and flavors are embedded in the microcapsules, the wall material of the microcapsules is a cellulose ether derivative, the sustained-release aid is a water-soluble polyhydroxy compound, and the mass proportion of the sustained-release aid in the preparation raw materials is 0.64-5.8%.

2. The sustained-release nicotine oral product according to claim 1, characterized in that: The water-soluble polyhydroxy compound is a polar water-soluble polyhydroxy compound; preferably, the water-soluble polyhydroxy compound includes at least one of propylene glycol, glycerol and polyethylene glycol.

3. The sustained-release nicotine oral product according to claim 1, characterized in that: The cellulose ether derivative contains ethoxy groups, preferably ethyl cellulose.

4. The sustained-release nicotine oral product according to claim 1, characterized in that: The mass ratio of the cellulose ether derivative to the water-soluble polyhydroxy compound is 3:10-7:

1.

5. The sustained-release nicotine oral product according to claim 1, characterized in that: The embedding rate of the microcapsules is between 18% and 24%.

6. The sustained-release nicotine oral product according to any one of claims 1 to 5, characterized in that: The functional auxiliary agent includes at least one of a filler, a preservative, a flavoring agent and a sweetener; preferably, the filler is at least one of modified starch, microcrystalline cellulose, corn starch and carboxymethyl cellulose; preferably, the sweetener is at least one of erythritol, mogroside, stevioside, neotame, trehalose, honey and glucose; preferably, the sustained-release nicotine oral preparation includes the following raw materials in parts by weight:

7. The sustained-release nicotine oral product according to any one of claims 1 to 5, characterized in that: The sustained-release nicotine oral product is a nicotine bag.

8. A method for preparing a sustained-release nicotine oral product, characterized in that: The raw materials for preparing the sustained-release nicotine oral product include fillers, preservatives, microcapsules, flavoring agents, sustained-release aids, sweeteners and water. Nicotine / salt and flavors are embedded in the microcapsules. The wall material of the microcapsules is a cellulose ether derivative, and the sustained-release aid is a water-soluble polyhydroxy compound. The preparation method comprises the following steps: S1, mixing a filler, a preservative and microcapsules to obtain a mixture I; S2, mixing the flavoring agent, the sustained-release aid and the sweetener and adding them to the mixture I; S3. Adjust the moisture content to obtain.

9. The method for preparing the sustained-release nicotine oral product according to claim 8, characterized in that: The preparation process of the microcapsule comprises the following steps: adding ethyl cellulose, nicotine / salt and flavor into an organic solvent, then adding into an aqueous solution containing a non-ionic surfactant or an organic solvent-water mixture to prepare an emulsion, and freeze-drying to obtain the microcapsule.

10. The preparation method according to claim 8 or 9, characterized in that: In step S3, the moisture content is adjusted to 10-40%.

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