Anti-dandruff oil-control composition and preparation method thereof

Abstract

The invention relates to the field of daily chemical products, and discloses an anti-dandruff and oil-control composition and a preparation method thereof. The anti-dandruff and oil-control composition comprises the following components: a core component and an auxiliary material. The preparation method comprises the following steps: 1) preparing raw materials; 2) preparing a phase A; 3) preparing a phase B; 4) mixing; and 5) homogenizing. According to the anti-dandruff and oil-control composition provided by the invention, the oil-control component, the anti-dandruff component and the conditioner are added as core components from five dimensions of oil control, malassezia inhibition, inflammation resistance, moisturizing and oxidation resistance, so that the sebum secretion balance is maintained, the anti-dandruff effect can be achieved by inhibiting bacteria, and the components of the composition are mild and non-irritant. According to the preparation method, the production efficiency is improved, the operation process is simple and convenient, and the preparation method is suitable for industrial production.

Description

Technical Field

[0001] The invention relates to the field of daily chemical products, and in particular to an anti-dandruff and oil-controlling composition and a preparation method thereof. Background Art

[0002] Pityriasis capitis, commonly known as dandruff, is a chronic, recurring and common scalp problem. Dandruff develops in three stages: the first stage is the appearance of scales; the second stage is accompanied by itching; the third stage is the appearance of erythema, i.e. seborrheic dermatitis. Dandruff is the product of the metabolism of epidermal cells on the human head. Epidermal cells continue to proliferate and divide on the scalp, move upward and gradually form keratin. The shedding and death of epidermal cells is a normal physiological process, and dandruff causes epidermal cells to shed faster than normal. The causes of dandruff include: excessive skin oil, fungal infection (Malassezia), dry scalp, skin inflammation, improper shampooing and care habits, and bad eating and living habits.

[0003] Although the anti-dandruff and oil-control products on the market are updated generation after generation, most users are not satisfied with the anti-dandruff effects of the products. The main reasons are as follows: First, most of the anti-dandruff and oil-control products currently on the market have added anti-dandruff fungicides such as zinc pyrithione (ZPT), piroctone ethanolamine (OCT), ketoconazole, and hexamidine II, which are not only irritating but also have side effects; secondly, the surfactant system of some products is over-cleansing, which will also aggravate scalp inflammation and lead to worse anti-dandruff effects of the products. Second, the current treatment methods for dandruff mainly focus on inhibiting Malassezia, but there are many factors that affect dandruff, involving multiple factors such as scalp microecology, stratum corneum lipids, and scalp barrier, which leads to poor anti-dandruff and oil-control effects of the products.

[0004] More and more people are troubled by dandruff, but the existing anti-dandruff and oil-control products are highly irritating and have a single anti-dandruff treatment method, which leads to consumers' dissatisfaction with the effects of anti-dandruff and oil-control products. This makes more consumers more eager to have anti-dandruff and oil-control hair care products. Therefore, it is of great significance to study a mild anti-dandruff and oil-control composition that can inhibit the production of dandruff in multiple dimensions. Summary of the invention

[0005] In view of the above defects or improvement needs of the prior art, the present invention provides an anti-dandruff oil-control composition and a preparation method thereof. The present invention solves the problems of existing anti-dandruff oil-control products being highly irritating and having poor anti-dandruff oil-control effects, and provides a mild anti-dandruff oil-control composition that inhibits dandruff production in multiple dimensions, which not only combines the maintenance of sebum secretion balance and the achievement of anti-dandruff effects, but also has natural active ingredients that are green, mild and non-irritating. Adding the composition to shampoo or hair care products can effectively improve the anti-dandruff oil-control effects of the products.

[0006] The first aspect of the present invention aims to provide an anti-dandruff and oil-control composition.

[0007] The purpose of the second aspect of the present invention is to provide a method for preparing the anti-dandruff and oil-control composition of the first aspect of the present invention.

[0008] In order to achieve the above object, the technical solution adopted by the present invention is: The first aspect of the present invention provides an anti-dandruff and oil-control composition, which comprises the following components, each component being calculated by mass percentage: 38-54% of a core component and 46-62% of an auxiliary material.

[0009] Preferably, the core ingredient comprises the following components, and the weight percentage of each component in the anti-dandruff and oil-control composition is: 15-20% of oil-control ingredient, 15-20% of anti-dandruff ingredient and 8-14% of conditioning agent.

[0010] Preferably, the auxiliary materials include the following components, and the mass percentage of each component in the anti-dandruff and oil-control composition is: surfactant 10-15%, emulsifier 1%-2.5%, preservative 0.1%-0.3%, chelating agent 0.02%-0.2%, and deionized water 34.88-44%.

[0011] More preferably, the oil-controlling ingredients are dandelion extract, magnolia bark extract and tea polyphenols.

[0012] More preferably, the anti-dandruff ingredients are ginger volatile oil and Sophora alopecuroides extract.

[0013] Further preferably, the conditioning agent is hydroxypropyltrimethylammonium chloride chitosan, ectoine and madecassoside.

[0014] Further preferably, the surfactant includes at least anionic surfactants and zwitterionic surfactants, and the surfactant is at least two of betaine, cocoyl betaine, cocamidopropyl betaine, sodium lauroyl sarcosinate, sodium cocoyl glycinate and sodium methyl lauroyl taurate.

[0015] Further preferably, the emulsifier includes a water-soluble emulsifier and an oil-soluble emulsifier, wherein the water-soluble emulsifier is at least one of disodium cetearyl sulfosuccinate and sodium stearoyl glutamate; the oil-soluble emulsifier is at least one of steareth-2, steareth-21, arachidyl glucoside, PEG-100 stearate, glyceryl stearate, cetearyl glucoside, sodium stearoyl glutamate, disodium cetearyl sulfosuccinate, PEG-10 dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone, sorbitan oleate and sorbitan stearate.

[0016] Further preferably, the preservative includes at least one of methylparaben, propylparaben, phenoxyethanol, sodium benzoate and potassium sorbate.

[0017] Further preferably, the chelating agent is at least one of disodium EDTA, trisodium EDTA, tetrasodium EDTA and pentasodium DTPA.

[0018] More preferably, the mass ratio of the oil-controlling ingredients dandelion extract, magnolia bark extract and tea polyphenols is 1:1:2.

[0019] More preferably, in the anti-dandruff ingredient, the mass ratio of ginger volatile oil to Sophora alopecuroides extract is 1:1.

[0020] More preferably, in the conditioner, the mass ratio of hydroxypropyltrimethylammonium chloride chitosan, ectoine and madecassoside is 2:1:1.

[0021] More preferably, the mass ratio of the anionic surfactant to the zwitterionic surfactant is (0.5-2):1, and the surfactant is a combination of sodium lauroyl sarcosinate and cocamidopropyl betaine.

[0022] The second aspect of the present invention provides a method for preparing an anti-dandruff and oil-controlling composition according to the first aspect of the present invention, the method comprising the following steps: 1) Raw material preparation S1. Preparation of dandelion extract and magnolia bark extract: 150 g of dandelion and magnolia bark were weighed and placed in round-bottom flasks respectively, soaked in 10 times the amount of water for 2 h, heated in a water bath for reflux extraction for 45 min, filtered through a 200-mesh filter cloth while hot, and the filtrate was collected; 9 times the amount of water was added to the residue for reflux extraction for 20 min, filtered through a 200-mesh filter cloth while hot, the filtrates were combined, and concentrated to 400 mL at 50°C under reduced pressure; S2. Preparation of ginger volatile oil: 200 g of medicinal material powder was placed in a round-bottom flask, 1800 mL of deionized water was added, and ultrasonic treatment was performed for 15 min at an ultrasonic power of 500 W. After extraction at 180 °C for 2 h, the liquid in the volatile oil extractor was collected, and centrifuged at 5000 r / min for 5 min to collect the upper liquid. S3. Preparation of Sophora alopecuroides extract: 100 g of Sophora alopecuroides dried medicinal material powder was taken and placed in a round-bottom flask. An appropriate amount of water was added, and sodium phosphate buffer solution was added to adjust the solution pH to 6. Then, cellulase (enzyme activity 1500 U / g) was added at a ratio of 1:1000 g. The mixture was heated to 45°C, and enzymolysis was performed in a constant temperature water bath for 4.5 h. Then, hydrochloric acid was added at a ratio of 4:1000 mL, with a solid-liquid ratio of 1:16. The mixture was extracted twice, with the first extraction time of 1.5 h and the second extraction time of 1 h. The mixture was filtered through a 200-mesh filter cloth, and the filtrate was combined and concentrated to 300 mL at 50°C under reduced pressure. 2) Prepare phase A: add surfactant, chelating agent, water-soluble emulsifier, oil control ingredient, conditioner, deionized water and Sophora alopecuroides extract into the water phase pot, start stirring at a speed of 160-200 r / min, heat to 45-55°C, and disperse evenly to obtain phase A; 3) Prepare phase B: add oil-soluble emulsifier and ginger volatile oil into the oil phase pot, start stirring, the speed is 900-960r / min, heat to 60-70°C, and disperse evenly, which is phase B; 4) Mixing: Pump phase A of step 2) and phase B of step 3) into a high-performance disperser, homogenize at high speed under vacuum at a speed of 8000-9000 r / min, stir evenly, and cool under stirring to obtain mixture I; 5) Homogenization: Add the preservative to the mixture I obtained in step 4 and stir evenly, homogenize for 5-10 minutes, and homogenize until the mixture is evenly mixed to obtain the anti-dandruff and oil-control composition.

[0023] Compared with the prior art, the present invention has the following beneficial effects: The present invention provides an anti-dandruff oil-control composition and a preparation method thereof. The anti-dandruff oil-control composition provided by the present invention not only maintains the balance of sebum secretion, but also can inhibit bacteria and play an anti-dandruff effect from five dimensions of oil control, inhibition of Malassezia, anti-inflammatory, moisturizing and anti-oxidation, by adding oil control ingredients, anti-dandruff ingredients and conditioners, and the composition ingredients are mild and non-irritating. For those who are troubled by oily hair, the present invention adopts dandelion extract, magnolia bark extract and tea polyphenols to coordinate and match, which can enhance the antibacterial and anti-inflammatory effects, inhibit the growth of Malassezia, avoid excessive secretion of scalp oil, balance the scalp microecological environment, and repair the scalp stratum corneum, so that the composition of the present invention can play an excellent oil control effect, and can also play an anti-itching and scalp soothing effect. For those who are troubled by dandruff and itchy head, the present invention adopts ginger extract and sophora alopecuroides extract for use, and ginger volatile oil and sophora alopecuroides extract both have antibacterial, anti-inflammatory and antioxidant effects. As pure plant ingredients, they are mild and non-irritating to the human body, environmentally friendly and pollution-free. For those who are troubled by dry hair and sensitive scalp, the present invention adopts hydroxypropyltrimethylammonium chloride chitosan, ectoine and madecassoside, among which the combination of ectoine and madecassoside has a synergistic effect in anti-inflammatory effect, and dihydroxypropyltrimethylammonium chloride chitosan has good antioxidant, biocompatibility, moisture absorption and moisturizing properties, antibacterial properties, biodegradability, film-forming properties and non-toxicity. It can not only provide moisturizing and antibacterial effects for the formula without causing allergic reactions, but also because of its high stability, it can improve the stability and bioavailability of other active ingredients in the formula.

[0024] The present invention provides a method for preparing an anti-dandruff oil-control composition, the method comprising the following steps: 1) raw material preparation; 2) preparation of phase A; 3) preparation of phase B; 4) mixing; 5) homogenization. The present invention provides a method for preparing a dandelion extract and a magnolia bark extract, and the inventor has found through multiple experiments that adding a water soaking step before extraction and appropriately extending the soaking time can achieve a better oil control effect of the extracted active ingredients; the first extraction is extracted with 10 times the amount of water for 45 minutes, and the second extraction is extracted with 9 times the amount of water for 20 minutes, which can improve the efficiency of subsequent heating and reflux extraction, greatly shorten the extraction time, and can be applied to industrial production to save production costs. The present invention provides a method for preparing ginger volatile oil, which makes it easier to release the active ingredients by first ultrasonic treatment and then extraction, and the extraction time is shortened from the original 4 hours to 2 hours, and the efficacy of ginger volatile oil is not affected, thereby improving production efficiency. The preparation method of the sophora alopecuroides extract provided by the present invention improves the extraction rate by first enzymolysis with cellulase and then acid extraction with hydrochloric acid; and the present invention adjusts the material-liquid ratio to 1:16, which is more in line with the actual industrial production, and the two acid extraction times are shortened from the original 4h to 2.5h. The preparation method provided by the present invention not only improves the production efficiency but also has a simple operation process and is suitable for industrial production. DETAILED DESCRIPTION

[0025] The anti-dandruff and oil-control composition and the preparation method thereof provided by the present invention are now further described in detail in conjunction with specific examples, but the scope of the present invention is not limited thereto.

[0026] Unless otherwise specified, the materials used in this example were obtained from commercial sources.

[0027] In one aspect, the present invention provides an anti-dandruff and oil-control composition, which comprises the following components, each component being calculated by mass percentage: 38-54% of a core component and 46-62% of an auxiliary material.

[0028] The core ingredients include the following components, and the weight percentage of each component in the anti-dandruff and oil-control composition is: 15-20% of oil-control ingredients, 15-20% of anti-dandruff ingredients, and 8-14% of conditioning agents.

[0029] The auxiliary materials include the following components, and the weight percentage of each component in the anti-dandruff and oil-control composition is as follows: surfactant 10-15%, emulsifier 1%-2.5%, preservative 0.1%-0.3%, chelating agent 0.02%-0.2%, and deionized water 34.88-44%.

[0030] The oil-controlling ingredients are dandelion extract, magnolia bark extract and tea polyphenols.

[0031] The anti-dandruff ingredients are ginger volatile oil and sophora alopecuroides extract.

[0032] The conditioning agent is hydroxypropyltrimethylammonium chloride chitosan, ectoine and madecassoside.

[0033] The surfactant comprises at least an anionic surfactant and a zwitterionic surfactant, and the surfactant is at least two of betaine, cocoyl betaine, cocamidopropyl betaine, sodium lauroyl sarcosinate, sodium cocoyl glycinate and sodium methyl lauroyl taurate.

[0034] The emulsifier includes a water-soluble emulsifier and an oil-soluble emulsifier, wherein the water-soluble emulsifier is at least one of disodium cetearyl sulfosuccinate and sodium stearoyl glutamate; the oil-soluble emulsifier is at least one of steareth-2, steareth-21, arachidyl glucoside, PEG-100 stearate, glyceryl stearate, cetearyl glucoside, sodium stearoyl glutamate, disodium cetearyl sulfosuccinate, PEG-10 polydimethylsiloxane, PEG-9 polydimethylsiloxyethyl polydimethylsiloxane, sorbitan oleate and sorbitan stearate.

[0035] The preservative includes at least one of methylparaben, propylparaben, phenoxyethanol, sodium benzoate and potassium sorbate.

[0036] The chelating agent is at least one of disodium EDTA, trisodium EDTA, tetrasodium EDTA and pentasodium DTPA.

[0037] In the oil-controlling ingredient, the mass ratio of dandelion extract, magnolia bark extract and tea polyphenols is 1:1:2.

[0038] In the anti-dandruff component, the mass ratio of ginger volatile oil to Sophora alopecuroides extract is 1:1.

[0039] In the conditioning agent, the mass ratio of hydroxypropyltrimethylammonium chloride chitosan, ectoine and madecassoside is 2:1:1.

[0040] Furthermore, the mass ratio of the anionic surfactant to the zwitterionic surfactant is (0.5-2):1, and the surfactant is a combination of sodium lauroyl sarcosinate and cocamidopropyl betaine.

[0041] Furthermore, as a natural plant extract, dandelion extract is rich in a variety of ingredients with antioxidant and anti-inflammatory effects, such as flavonoids and flavonoid compounds, which can inhibit the production of inflammatory factors and reduce inflammatory damage to tissues. In addition, dandelion extract can reduce inflammatory response and tissue damage by inhibiting the expression of proteins such as nuclear factor KB (NF-kB), cyclooxygenase 2 (COX-2), and inducible nitric oxide synthase (iNOS). Among them, NF-kB is a signaling molecule in cells that can regulate processes such as cell apoptosis and inflammatory response; COX-2 and iNOS are enzymes closely related to inflammatory response. Inhibiting the expression of these proteins can reduce inflammatory response in the body and promote tissue healing and repair. Studies have shown that when dandelion extract is used as an acne-removing product, the ingredients in dandelion extract can be used to control the skin's secretion of excess oil, thereby achieving an oil control effect.

[0042] Furthermore, Magnolia officinalis is the dried bark, root bark and branch bark of Magnolia officinalis or Magnolia officinalis of the Magnoliaceae family. Chinese medicine believes that Magnolia officinalis has the effects of drying dampness and eliminating phlegm, lowering qi and removing fullness. It is mainly used to treat dampness stagnation, abdominal distension, vomiting and diarrhea, food accumulation and qi stagnation, abdominal distension and constipation, phlegm and cough. Magnolia officinalis and its isomers and magnolia officinalis are active ingredients with high content in Magnolia officinalis medicinal materials, and their content has become an important quality indicator of Magnolia officinalis medicinal materials. Studies have found that Magnolia officinalis extract has anti-inflammatory effects and fights against oxidative stress damage caused by free radicals in the body. When Magnolia officinalis extract is used as an acne product, it has a good oil control effect.

[0043] Furthermore, tea polyphenols (TP) are a major natural product in tea leaves. They are a complex of polyphenolic compounds with catechins as the main component, including flavonoids, anthocyanins, phenolic acids, etc. Tea polyphenols are mainly catechins, which are mainly composed of catechins (EC), epigallocatechin (EGC), epigallocatechin gallate (ECG) and epigallocatechin gallate (EGCG), among which EGCG is the catechin with the highest content. Tea polyphenols have a variety of biological activities, such as antioxidant activity, anticancer activity, antibacterial activity and metabolic syndrome regulation activity.

[0044] Among them, tea polyphenols can activate the endogenous antioxidant (Nrf2) pathway and regulate pro-inflammatory and anti-inflammatory signal transduction factors, such as TNF-α, Toll-like receptors and COX-2, to play an anti-inflammatory and immune regulatory role. These inflammatory factors are related to abnormal sebaceous gland secretion. When their levels are reduced, they can effectively improve skin inflammation caused by abnormal sebaceous gland secretion, thereby indirectly achieving oil control. Studies have shown that the PI3K--AKT-mTORC1 signaling pathway plays an important regulatory role in lipid metabolism, and the EGCG contained in tea polyphenols can inhibit the PI3K-AKT-mTORC1 signaling pathway, thereby reducing oil secretion. In summary, tea polyphenols have a good oil control effect.

[0045] Further, ginger (Zingiber officinale Roscoe), a perennial herb, has thick roots, yellow-white cross-section, and a strong spicy aroma. It is edible and can also be used for medicinal purposes. Ginger has the effects of dispelling cold, warming the middle and stopping vomiting, and warming the lungs and stopping coughing. The chemical components of ginger are many and complex. There are many chemical components that have been discovered and determined so far, which are basically divided into volatile oils, oleoresins, and diphenylcycloheptanes, and volatile oils and oleoresins are collectively referred to as ginger oil. Among them, gingerol is one of the main active ingredients of ginger, which has the effects of promoting blood circulation in the head skin, effectively preventing hair loss, and inhibiting scalp itching. The ginger volatile oil selected by the present invention has physiological activities such as antibacterial, anti-inflammatory, anti-gastric ulcer, and antioxidant, and has a strong aromatic taste. Studies have shown that ginger volatile oil has a good inhibitory effect on Malassezia, which is the main cause of dandruff.

[0046] Further, Sophora alopecuroides is the dried aerial part of Sophora alopecuroides, a plant of the genus Sophora in the Leguminosae family. It is mainly distributed in the desert and semi-desert areas of northern my country, and is rich in resources in Gansu, Qinghai and other regions. Sophora alopecuroides is bitter and cold in nature, and has the effects of clearing heat, detoxifying, promoting dampness, killing insects, and anti-cancer. It is used for diseases such as sore throat, lung heat cough, and hepatitis B. For a long time, there have been reports of using Sophora alopecuroides preparations to treat infectious diseases such as skin anthrax and acute bacillary dysentery. Through modern pharmacological studies on Sophora alopecuroides, it was found that its active ingredients have strong in vitro antibacterial activity. The main ingredients in Sophora alopecuroides extract are sophoridine, which is one of the higher alkaloids contained in Sophora alopecuroides. Studies have found that it has anti-tumor, anti-arrhythmic, anti-inflammatory, antibacterial and immunosuppressive effects, and its antibacterial activity against Malassezia is strong. In summary, as a pure plant ingredient, Sophora alopecuroides extract is safe, green, pollution-free, harmless, and inexpensive, and has broad application prospects in long-term antibacterial applications.

[0047] Furthermore, chitosan (polyglucosamine (1-4)-2-amino-BD) is odorless and tasteless, and is a product of N-deacetylation of chitin. Chitosan has good biodegradability, cell affinity and biological effect, adsorption, film-forming, permeability, fiber-forming, hygroscopicity and moisture retention, but chitosan can only be dissolved in acidic solutions. It does not dissolve in solutions with a pH value greater than 6.5, which has always restricted its application. Hydroxypropyltrimethylammonium chloride chitosan belongs to quaternized chitosan, a derivative of chitosan, and a linear cationic polysaccharide with good water solubility. Quaternized chitosan not only overcomes the problem of poor water solubility of chitosan, maintains the advantages of chitosan, but also has the properties of quaternary ammonium salts. The hydroxypropyltrimethylammonium chloride chitosan selected in the present invention has good antioxidant properties, biocompatibility, hygroscopicity and moisture retention, antibacterial properties, biodegradability, film-forming properties and non-toxicity. It can not only provide moisturizing and antibacterial effects for the formula without causing allergic reactions, but also because of its high and low temperature stability, it can improve the stability and bioavailability of other active ingredients in the formula.

[0048] Furthermore, Ectoin (also known as tetrahydromethylpyridine carboxylic acid, Ectoin, EC) is an amino acid derivative, a natural protective ingredient produced by halophilic bacteria in the outer layer of cells under high temperature, dryness, strong ultraviolet radiation, and high salinity environments. Ectoin is also a strongly hydrophilic substance. Its structure has a strong electronegativity and can easily form hydrogen bonds with water molecules, causing water molecules to be oriented around it and forming a protective, nourishing and stable hydration shell around cells, enzymes, proteins and other biological molecules, which can resist various external damages, thereby reducing the stimulation of external substances to skin cells, and at the same time has a long-lasting water-locking effect. In addition, Ectoin has excellent antioxidant, repair and anti-inflammatory properties, can repair damaged scalp cells, and improve cellular immune protection.

[0049] Furthermore, Centella asiatica is the dried whole herb of Centella asiatica of the genus Centella asiatica of the Apiaceae family, which was first recorded in the Shennong Bencao Jing. The main active ingredient is triterpenoid saponins. Studies have shown that total glycosides of Centella asiatica have multiple effects such as anti-ulcer, immunomodulation and induction of apoptosis, treatment of skin diseases, and anti-anxiety. Madecassoside (MC) selected in the present invention is one of the main components of triterpenoid saponins of Centella asiatica extract. Studies have shown that madecassoside has anti-inflammatory, antibacterial, moisturizing, anti-oxidation, and wound healing promotion functions.

[0050] Further, the present invention selects zwitterionic surfactant and anionic surfactant compound, can reduce the irritation of anionic surfactant to skin, make product more gentle. Preferably, the surfactant is at least two of betaine, cocoyl betaine, cocamidopropyl betaine, sodium lauroyl sarcosinate, sodium cocoyl glycinate and sodium methyl lauroyl taurate. Preferably, the surfactant is a combination of sodium lauroyl sarcosinate and cocamidopropyl betaine. The present invention finds after a large number of attempts that sodium lauroyl sarcosinate and cocamidopropyl betaine are selected to act together in the system, can form a close arrangement in the oil-water phase, the formed mixed micelles are uniformly wrapped with active functional ingredients, dispersed in the mixed system, the electrical repulsion of adsorption layer and charged ions is weakened, the flocculation and precipitation trend of the composition under temperature change are significantly suppressed, and the stability is significantly improved. Furthermore, the present invention finds that when the mass ratio of sodium lauroyl sarcosinate to cocamidopropyl betaine is (0.5-2):1, the compatibility of the formula promotes the antibacterial, anti-inflammatory, anti-dandruff and moisturizing soothing effects of the conditioning agent, oil control, and anti-dandruff ingredients to the greatest extent.

[0051] Furthermore, the anti-dandruff and oil-control composition provided by the present invention maintains the balance of sebum secretion and has an antibacterial and anti-dandruff effect from five dimensions: oil control, inhibition of Malassezia, anti-inflammation, moisturizing, and anti-oxidation by adding oil-control ingredients, anti-dandruff ingredients, and conditioners. Moreover, the ingredients of the composition are mild and non-irritating.

[0052] On the other hand, the present invention also provides a method for preparing an anti-dandruff and oil-controlling composition, comprising the following steps: 1) Raw material preparation S1. Preparation of dandelion extract and magnolia bark extract: 150 g of dandelion and magnolia bark were weighed and placed in round-bottom flasks respectively, and 10 times the amount of water was added to soak for 2 h. The mixture was heated and refluxed in a water bath for the first extraction for 45 min. The mixture was filtered through a 200-mesh filter cloth while hot, and the filtrate was collected. The residue was added with 9 times the amount of water and refluxed for the second extraction for 20 min. The mixture was filtered through a 200-mesh filter cloth while hot, and the filtrates were combined and concentrated to 400 mL at 50°C under reduced pressure. S2. Preparation of ginger volatile oil: 200 g of medicinal material powder was placed in a round-bottom flask, 1800 mL of deionized water was added, and ultrasonic treatment was performed for 15 min at an ultrasonic power of 500 W. After extraction at 180 °C for 2 h, the liquid in the volatile oil extractor was collected, and centrifuged at 5000 r / min for 5 min to collect the upper liquid. S3. Preparation of Sophora alopecuroides extract: 100 g of Sophora alopecuroides dried medicinal material powder was taken and placed in a round-bottom flask. An appropriate amount of water was added, and sodium phosphate buffer solution was added to adjust the solution pH to 6. Then, cellulase (enzyme activity 1500 U / g) was added at a ratio of 1:1000 g. The mixture was heated to 45°C, and enzymolysis was performed in a constant temperature water bath for 4.5 h. Then, hydrochloric acid was added at a ratio of 4:1000 mL, with a solid-liquid ratio of 1:16. The mixture was extracted twice, with the first extraction time of 1.5 h and the second extraction time of 1 h. The mixture was filtered through a 200-mesh filter cloth, and the filtrate was combined and concentrated to 300 mL at 50°C under reduced pressure. 2) Prepare phase A: add surfactant, chelating agent, water-soluble emulsifier, oil control ingredient, conditioner, deionized water and Sophora alopecuroides extract into the water phase pot, start stirring at a speed of 160-200 r / min, heat to 45-55°C, and disperse evenly to obtain phase A; 3) Prepare phase B: add oil-soluble emulsifier and ginger volatile oil into the oil phase pot, start stirring, the speed is 900-960r / min, heat to 60-70°C, and disperse evenly, which is phase B; 4) Mixing: Pump phase A of step 2) and phase B of step 3) into a high-performance disperser, homogenize at high speed under vacuum at a speed of 8000-9000 r / min, stir evenly, and cool under stirring to obtain mixture I; 5) Homogenization: Add the preservative to the mixture I obtained in step 4 and stir evenly, homogenize for 5-10 minutes, and homogenize until the mixture is evenly mixed to obtain the anti-dandruff and oil-control composition.

[0053] Furthermore, the preparation method of dandelion extract and magnolia bark extract provided by the present invention is that the inventors found through multiple experiments that adding a water soaking step before extraction and appropriately extending the soaking time can achieve better oil control effect of the extracted active ingredients. The first extraction is extracted with 10 times the amount of water for 45 minutes, and the second extraction is extracted with 9 times the amount of water for 20 minutes. This can improve the efficiency of subsequent heating reflux extraction, greatly shorten the extraction time, and can be applied to industrial production to save production costs.

[0054] Furthermore, the preparation method of ginger volatile oil provided by the present invention is to first perform ultrasonic treatment and then perform heating extraction by a volatile oil extractor, so that the effective ingredients are more easily released, the extraction time is shortened from the original 4 hours to 2 hours, and the effect of ginger volatile oil is not affected, thereby improving production efficiency.

[0055] Furthermore, the method for preparing the sophora alopecuroides extract provided by the present invention improves the extraction rate by first enzymolysis with cellulase and then acid extraction with hydrochloric acid; and the present invention adjusts the material-liquid ratio to 1:16, which is more in line with industrial production practices, and the time for the two acid extractions is shortened from the original 4 hours to 2.5 hours.

[0056] Examples The components in Examples 1-3 were configured according to Table 1 below.

[0057] Table 1 Mass percentage of each component in Examples 1-3

[0058] The preparation method of the above composition comprises the following steps: 1. Raw material preparation S1. Preparation of dandelion extract and magnolia bark extract: 150 g of dandelion and magnolia bark were weighed and placed in round-bottom flasks respectively, soaked in 10 times the amount of water for 2 h, heated in a water bath for reflux extraction for 45 min, filtered through a 200-mesh filter cloth while hot, and the filtrate was collected; 9 times the amount of water was added to the residue for reflux extraction for 20 min, filtered through a 200-mesh filter cloth while hot, the filtrates were combined, and concentrated to 400 mL at 50°C under reduced pressure; S2. Preparation of ginger volatile oil: 200 g of medicinal material powder was placed in a round-bottom flask, 1800 mL of deionized water was added, and ultrasonic treatment was performed for 15 min at an ultrasonic power of 500 W. After extraction at 180 °C for 2 h, the liquid in the volatile oil extractor was collected, and centrifuged at 5000 r / min for 5 min to collect the upper liquid. S3. Preparation of Sophora alopecuroides extract: 100 g of Sophora alopecuroides dried medicinal material powder was taken and placed in a round-bottom flask. An appropriate amount of water was added, and sodium phosphate buffer solution was added to adjust the solution pH to 6. Then, cellulase (enzyme activity 1500 U / g) was added at a ratio of 1:1000 g. The mixture was heated to 45°C, and enzymolysis was performed in a constant temperature water bath for 4.5 h. Then, hydrochloric acid was added at a ratio of 4:1000 mL, with a solid-liquid ratio of 1:16. The mixture was extracted twice, with the first extraction time of 1.5 h and the second extraction time of 1 h. The mixture was filtered through a 200-mesh filter cloth, and the filtrate was combined and concentrated to 300 mL at 50°C under reduced pressure. 2. Prepare phase A: add surfactant, chelating agent, water-soluble emulsifier, oil control ingredient, conditioner, deionized water and Sophora alopecuroides extract into the water phase pot, start stirring at a speed of 200 r / min, heat to 50°C, and disperse evenly to obtain phase A; 3. Prepare phase B: Add the oil-soluble emulsifier and ginger volatile oil into the oil phase pot, start stirring, speed 900r / min, heat to 60°C, and disperse evenly as phase B; 4. Mixing: Pump phase A of step 2) and phase B of step 3) into a high-performance disperser, homogenize at high speed under vacuum at a speed of 8000 r / min, stir evenly, and cool under stirring to obtain mixture I; 5. Homogenization: Add the preservative to the mixture I obtained in step 4 and stir evenly. Homogenize for 10 minutes and homogenize until the mixture is evenly mixed to obtain the anti-dandruff and oil-controlling composition.

[0059] Comparative Example 1 The difference between Comparative Example 1 and Example 1 is that, in Comparative Example 1, dandelion extract and magnolia bark extract are not added, but tea polyphenols with a content equivalent to that of dandelion extract and magnolia bark extract in Example 1 are added.

[0060] Comparative Example 2 The difference between Comparative Example 2 and Example 1 is that, in Comparative Example 2, Magnolia bark extract and tea polyphenols are not added, but dandelion extract having the same content of Magnolia bark extract and tea polyphenols as that in Example 1 is added.

[0061] Comparative Example 3 The difference between Comparative Example 3 and Example 1 is that, in Comparative Example 3, dandelion extract and tea polyphenols are not added, but Magnolia bark extract having the same content of dandelion extract and tea polyphenols as that in Example 1 is added.

[0062] Comparative Example 4 The difference between Comparative Example 4 and Example 1 is that, in Comparative Example 4, ginger volatile oil is not added, but a Sophora alopecuroides extract having a content of ginger volatile oil equivalent to that of Example 1 is added.

[0063] Comparative Example 5 The difference between Comparative Example 5 and Example 1 is that, in Comparative Example 5, no Sophora alopecuroides extract is added, and ginger volatile oil is added in an amount equivalent to that of Sophora alopecuroides extract in Example 1.

[0064] Comparative Example 6 The difference between Comparative Example 6 and Example 1 is that Comparative Example 6 does not add hydroxypropyltrimethylammonium chloride chitosan and madecassoside, but adds ectoine with a content equivalent to that of hydroxypropyltrimethylammonium chloride chitosan and madecassoside in Example 1.

[0065] Comparative Example 7 The difference between Comparative Example 7 and Example 1 is that Comparative Example 7 does not add ectoine and hydroxypropyltrimethylammonium chloride chitosan, and adds hydroxymadecassoside with a content equivalent to that of ectoine and hydroxypropyltrimethylammonium chloride chitosan in Example 1.

[0066] Comparative Example 8 The difference between Comparative Example 8 and Example 1 is that Comparative Example 8 does not add hydroxymadecassoside and ectoine, but adds hydroxypropyltrimethylammonium chloride chitosan with the same content of hydroxymadecassoside and ectoine as that in Example 1.

[0067] Test Example 1 This test example evaluates the safety of the anti-dandruff and oil-control compositions prepared in Examples 1-3 and Comparative Examples 1-8, and tests the potential for the test samples to cause adverse reactions on human skin. The test refers to the relevant requirements and determination methods of the "Human Skin Patch Test" as stated in the "Technical Specifications for Safety of Cosmetics" (2015 edition).

[0068] 1. Test Preparation 1. Test sample: the anti-dandruff and oil-control composition prepared in Examples 1-3 and Comparative Examples 1-8; 2. Subjects: 110 volunteers were selected, half of them were male and half were female, aged 20-35 years old, and they did not suffer from inflammatory skin diseases or highly sensitive constitutions; they were divided into 11 groups, with 10 people in each group; 3. Test materials: informed consent form of the subjects, patch tester (area ≤50m2, depth about 1mm), hypoallergenic adhesive tape, waterproof marker, patch test ruler, magnifying glass and skin occlusion patch test record form; 2. Test steps 1. Clean the skin on the flexor side of the forearm of the subject and keep the tested area dry; 2. Weigh 0.020-0.025g of the test sample and place it in the small chamber of the spot tester; the control well is a blank control (no substance is placed); 3. Apply the patch tester with the test sample added in step 2 to the back or curved side of the forearm of the subject with a hypoallergenic tape, and gently press it with the palm of your hand to evenly apply it to the skin for 24 hours; 4. Observation: Observe the skin reaction 30 minutes (after the indentation disappears), 6 hours, 12 hours, 24 hours and 48 hours after removing the test sample spot tester, and record the observation results according to the standards in Table 2.

[0069] Table 2 Skin reaction grading standards for occlusive patch test

[0070] 3. Test results The human skin closed patch test showed that the experimental results of all subjects were negative results, and no adverse skin reactions occurred, indicating that the anti-dandruff and oil-control composition prepared by the present invention will not cause allergic reactions, is non-irritating, and has high safety.

[0071] Test Example 2 This test example evaluates the physicochemical stability of the anti-dandruff and oil-control compositions prepared in Examples 1-3 and Comparative Examples 1-8, and the test is performed according to the determination method of the standard GB / T 29679-2013.

[0072] 1. High temperature stability The anti-dandruff and oil-control compositions prepared in Examples 1-3 and Comparative Examples 1-8 were placed at 40° C. for 48 hours. If no stratification of the composition was observed after returning to room temperature, the high-temperature stability was recorded as "excellent"; if stratification of the composition was observed after returning to room temperature, the high-temperature stability was recorded as "poor".

[0073] 2. Low temperature stability The compositions for relieving itching, removing dandruff and controlling oil prepared in Examples 1-3 and Comparative Examples 1-8 were placed at -8°C for 48 hours. If no stratification of the composition was observed after returning to room temperature, the low-temperature stability was recorded as "excellent"; if stratification of the composition was observed after returning to room temperature, the low-temperature stability was recorded as "poor".

[0074] 3. Test results The specific test results are shown in Table 3.

[0075] Table 3 Evaluation results of physical and chemical stability of different test samples

[0076] The physicochemical stability evaluation results of the anti-dandruff and oil-control compositions prepared in Examples 1-3 and Comparative Examples 1-8 show that, except for Comparative Example 6, which has a poor evaluation result, the evaluation results of the other test samples are all excellent, indicating that the anti-dandruff and oil-control compositions prepared by the present invention have good physicochemical stability, among which hydroxypropyltrimethylammonium chloride chitosan plays a key role in the stability of other active ingredients.

[0077] Test Example 3 In this test example, the anti-dandruff and oil-control compositions prepared in Examples 1-3 and Comparative Examples 1-8 were evaluated for their effects.

[0078] 1. Test Preparation 1. Test subjects: 110 volunteers were screened, including 55 males and 55 females, aged 20-50 years old, with dandruff, oily scalp and itchy scalp problems. They were randomly divided into 11 groups, with 10 people in each group, half of them were males and half were females; 2. Test samples: anti-dandruff and oil-control compositions prepared in Examples 1-3 and Comparative Examples 1-8.

[0079] 2. Test methods 1. Depending on the thickness of the hair, use 20-50ml each time, once every two days, for 2 consecutive months; 2. The following indicators were scored: oil control, anti-dandruff, and antipruritic; the score was scored on a 10-point scale, with the highest score being 10 and the lowest score being 0. The average score of each volunteer was taken.

[0080] 3. Test results The specific test results are shown in Table 4.

[0081] Table 4 Evaluation results of the use effects of different test samples

[0082] The results of the physicochemical stability evaluation of the anti-dandruff and oil-control compositions prepared in Examples 1-3 and Comparative Examples 1-8 show that the anti-dandruff and oil-control compositions prepared in Examples 1-3 have better oil control, anti-dandruff and antipruritic effects, and the overall use effect score is better than the anti-dandruff and oil-control compositions prepared in Comparative Examples 1-8. Among them, the oil control effect of Comparative Examples 1-3 is the worst, indicating that dandelion extract, magnolia bark extract and tea polyphenols have a good oil control effect, and the three ingredients must be used in combination to have a good oil control effect. The anti-dandruff and antipruritic effects of Comparative Examples 4 and 5 are the worst, indicating that ginger volatile oil and sophora alopecuroides extract have good antibacterial anti-dandruff and antipruritic effects, and the two are indispensable, with an effect of one plus one greater than two. The oil control, anti-dandruff and antipruritic effects of Comparative Examples 6 and 7 are poor relative to those of Comparative Example 8, indicating that the high and low temperature stability of hydroxypropyltrimethylammonium chloride chitosan can affect the efficacy of other components in the formula.

[0083] Test Example 4 This test example is to evaluate the antibacterial effect of the anti-dandruff oil-control composition prepared in Examples 1-3 and Comparative Examples 1-8. The test refers to the 2.1.8.2 antibacterial ring test of the Ministry of Health's 2002 edition of the "Technical Specifications for Disinfection" to determine the antibacterial effect of the test sample on Malassezia. The principle is to use the antibacterial agent to continuously dissolve and diffuse through agar to form different concentration gradients to show its antibacterial effect. The test is to judge whether it has antibacterial ability by the size of the antibacterial ring.

[0084] 1. Test Preparation 1. Test sample: the anti-dandruff and oil-control composition prepared in Examples 1-3 and Comparative Examples 1-8; 2. Test strain: Malassezia furfur (M. furfur ATCC44344), from Guangdong Microbiological Culture Collection Center; 3. Test materials: puncher, filter paper (5 mm diameter round Xinhua No. 1 qualitative filter paper, sterilized by pressure steam, dried at 120℃ for 2 h, and stored for later use), sterile tweezers, sterile cotton swab, Leeming & Notman culture medium plate and vernier caliper.

[0085] 2. Test steps 1. Preparation of antibacterial tablets: Take a number of sterile and dry filter paper sheets, use sterile tweezers to dip a little of the anti-dandruff and oil-control composition prepared in Examples 1-3 and Comparative Examples 1-8, spread the filter paper sheets evenly as much as possible, and then place the filter paper sheets flat in a clean sterile dish and dry them naturally at room temperature to obtain antibacterial tablets; 2. Preparation of negative control samples: Take sterile dry filter paper pieces, add sterile distilled water to each piece, dry and set aside; 3. Inoculation of test bacteria: Use a sterile cotton swab to inoculate a 5×10 6cfu / ml test bacterial suspension, apply evenly on the surface of Leeming & Notman medium plate 3 times. Each time you apply, the plate should be rotated 60°, and finally apply the cotton swab around the edge of the plate. Cover the plate and dry it at room temperature for 5 minutes; 4. Place the samples: Place 4 antibacterial tablets and 1 negative control sample on each plate, for a total of 5 samples. Use sterile tweezers to take the sample and place it on the surface of the plate. The distance between the centers of each sample should be more than 25 mm, and the distance from the edge of the plate should be more than 15 mm. After placing, use sterile tweezers to gently press the sample to make it close to the surface of the plate. Cover the plate and place it in a 32℃ constant temperature incubator for 7 days.

[0086] 5. Observation results: Use a vernier caliper to measure the diameter of the antibacterial ring (including the patch) and record it.

[0087] Note: When measuring the inhibition ring, you should choose an inhibition ring with uniform and completely sterile growth; the diameter should be measured with the outer edge of the inhibition ring as the boundary.

[0088] 3. Test results Evaluation regulations: (1) Determination of antibacterial effect: If the diameter of the antibacterial ring is greater than 7 mm, it is judged to have antibacterial effect; if the diameter of the antibacterial ring is less than or equal to 7 mm, it is judged to have no antibacterial effect.

[0089] (2) No inhibition zone should be produced in the negative control group, otherwise the test will be invalid.

[0090] No inhibition ring was produced in the negative control group, and the test was effective. The specific test results are shown in Table 5.

[0091] Table 5 Evaluation results of antibacterial effect of different test samples

[0092] The antibacterial effect evaluation results of the anti-dandruff oil-control compositions prepared in Examples 1-3 and Comparative Examples 1-8 show that the anti-dandruff oil-control compositions prepared in the present invention have a good antibacterial effect on Malassezia; among them, the antibacterial effects of Examples 1-3 are better than those of Comparative Examples 1-8, indicating that the anti-dandruff oil-control compositions prepared in the present invention have a good antibacterial effect on Malassezia, and there is a synergistic effect between the oil-control component, the anti-dandruff component and the conditioner, and their combined use can achieve a better antibacterial effect.

[0093] Test Example 5 This test example is to test the oil control efficacy of the anti-dandruff oil control composition prepared in Examples 1-3 and Comparative Examples 1-8. 5α-reductase (5α-reductase) is a membrane protease that depends on reduced coenzyme II (N ADPH). It is an important male hormone metabolic enzyme in the skin and can irreversibly convert testosterone (Testosterone, T) into dihydrotestosterone (Dihydrotestosterone, DHT). DHT is the most active male hormone and can induce excessive oil secretion by sebaceous glands. Therefore, by inhibiting the activity of 5α-reductase, the level of DHT can be reduced, thereby effectively alleviating the excessive oil secretion of sebaceous glands. In view of the relationship between 5α-reductase and sebaceous glands, the inhibitory effect of the test sample on 5α-reductase is usually detected to reflect the effect of sebum regulation, so as to characterize the oil control efficacy of the test sample.

[0094] 1. Treatment of control and test samples: 1. Test sample: the anti-dandruff and oil-control compositions prepared in Examples 1-3 and Comparative Examples 1-8; 2. Positive control (finasteride, purity ≥98%): dilute with anhydrous ethanol to a positive control concentration of 0.1%; 3. Negative control: PBS solution.

[0095] 2. Test operation steps: Set up a sample group, a positive control group, a negative control group and a blank group. Each group needs to have 3 parallels. Add different reagent solutions to the four groups, shake well, and measure the testosterone content in each group.

[0096] The calculation formula is shown in formula (1): Formula (1); The specific test results are shown in Table 6.

[0097] Table 6 Test results of oil control efficacy of different test samples

[0098] The results of 5α-reductase inhibition rate of the anti-dandruff and oil-control compositions prepared in Examples 1-3 and Comparative Examples 1-8 showed that the 5α-reductase inhibition rate of the positive control was >50%, indicating that the reaction system was effective, and the 5α-reductase inhibition rate of the anti-dandruff and oil-control compositions prepared in Examples 1-3 and Comparative Examples 1-8 was significantly different from that of the negative control group, indicating that the anti-dandruff and oil-control compositions provided by the present invention have good oil control effect; the 5α-reductase inhibition rate of Examples 1-3 is higher than that of Comparative Examples 1-8, indicating that the oil control component, anti-dandruff component and conditioner of the present invention are used in combination to have a better oil control effect, and the three components synergize and enhance each other, and none of them can be missing.

[0099] The above is a detailed description of the embodiments of the present invention, but the invention is not limited to the above embodiments. Various changes can be made within the knowledge of ordinary technicians in the relevant technical field without departing from the purpose of the present invention. In addition, the embodiments of the present invention and the features in the embodiments can be combined with each other without conflict.

Claims

1. An anti-dandruff and oil-control composition, characterized in that: The composition comprises the following components, each component being calculated by mass percentage: 38-54% of core component, 46-62% of auxiliary material; The core ingredients include the following components, and the weight percentage of each component in the anti-dandruff and oil-control composition is: 15-20% oil-control component, 15-20% anti-dandruff component and 8-14% conditioning agent; The auxiliary materials include the following components, and the mass percentage of each component in the anti-dandruff and oil-control composition is: surfactant 10-15%, emulsifier 1%-2.5%, preservative 0.1%-0.3%, chelating agent 0.02%-0.2%, and deionized water 34.88-44%.

2. The anti-dandruff and oil-control composition according to claim 1, characterized in that: The oil-controlling ingredients are dandelion extract, magnolia bark extract and tea polyphenols; The anti-dandruff ingredients are ginger volatile oil and Sophora alopecuroides extract; The conditioning agent is hydroxypropyltrimethylammonium chloride chitosan, ectoine and madecassoside; The surfactant comprises at least an anionic surfactant and a zwitterionic surfactant, and the surfactant is at least two of betaine, cocoyl betaine, cocamidopropyl betaine, sodium lauroyl sarcosinate, sodium cocoyl glycinate and sodium methyl lauroyl taurate; The emulsifier includes a water-soluble emulsifier and an oil-soluble emulsifier, wherein the water-soluble emulsifier is at least one of disodium cetearyl sulfosuccinate and sodium stearoyl glutamate; the oil-soluble emulsifier is at least one of steareth-2, steareth-21, arachidyl glucoside, PEG-100 stearate, glyceryl stearate, cetearyl glucoside, sodium stearoyl glutamate, disodium cetearyl sulfosuccinate, PEG-10 dimethicone, PEG-9 polydimethylsiloxyethyl dimethicone, sorbitan oleate and sorbitan stearate; The preservative includes at least one of methylparaben, propylparaben, phenoxyethanol, sodium benzoate and potassium sorbate; The chelating agent is at least one of disodium EDTA, trisodium EDTA, tetrasodium EDTA and pentasodium DTPA.

3. The anti-dandruff and oil-control composition according to claim 2, characterized in that: In the oil-controlling ingredient, the mass ratio of dandelion extract, magnolia bark extract and tea polyphenols is 1:1:2; In the anti-dandruff component, the mass ratio of ginger volatile oil to Sophora alopecuroides extract is 1:1; In the conditioning agent, the mass ratio of hydroxypropyltrimethylammonium chloride chitosan, ectoine and madecassoside is 2:1:1; The mass ratio of the anionic surfactant to the zwitterionic surfactant is (0.5-2):1, and the surfactant is a combination of sodium lauroyl sarcosinate and cocamidopropyl betaine.

4. A method for preparing an anti-dandruff and oil-controlling composition according to any one of claims 1 to 3, characterized in that: The steps include: 1) Raw material preparation: S1, preparation of dandelion extract and magnolia bark extract; S2, preparation of ginger volatile oil; S3, preparation of sophora alopecuroides extract; 2) Prepare phase A: add surfactant, chelating agent, water-soluble emulsifier, oil control component, conditioning agent, deionized water and Sophora alopecuroides extract into the water phase pot, start stirring, heat and disperse evenly to obtain phase A; 3) Prepare phase B: Add the oil-soluble emulsifier and ginger volatile oil into the oil phase pot, start stirring, heat, and disperse evenly to form phase B; 4) Mixing: Pump phase A of step 2) and phase B of step 3) into a high-performance disperser, homogenize at high speed under vacuum, stir evenly, and cool under stirring to obtain mixture I; 5) Homogenization: Add the preservative to the mixture I obtained in step 4) and stir evenly, homogenize for 5-10 minutes, and homogenize until the mixture is evenly mixed to obtain the anti-dandruff and oil-control composition.

5. The method for preparing an anti-dandruff and oil-controlling composition according to claim 4, characterized in that: The step S1 of preparing dandelion extract and magnolia bark extract comprises: weighing 150 g of dandelion and magnolia bark respectively, placing them in round-bottom flasks, adding 10 times the amount of water to soak for 2 hours, heating and refluxing in a water bath for 45 minutes, filtering with a 200-mesh filter cloth while hot, and collecting the filtrate; adding 9 times the amount of water to the residues for reflux extraction for 20 minutes, filtering with a 200-mesh filter cloth while hot, combining the filtrates, and concentrating under reduced pressure at 50° C. to 400 mL.

6. The method for preparing an anti-dandruff and oil-controlling composition according to claim 4, characterized in that: The step S2 of preparing ginger volatile oil comprises: taking 200 g of medicinal material powder, placing it in a round-bottom flask, adding 1800 mL of deionized water, first ultrasonically treating it for 15 min, with an ultrasonic power of 500 W; then extracting it at 180° C. for 2 h, collecting the liquid in the volatile oil extractor, centrifuging it at 5000 r / min for 5 min, and collecting the upper layer of liquid.

7. The method for preparing an anti-dandruff and oil-controlling composition according to claim 4, characterized in that: The step S3 of preparing the extract of Sophora alopecuroides comprises: taking 100 g of fine powder of dried medicinal material of Sophora alopecuroides, placing it in a round-bottom flask, adding an appropriate amount of water, adding sodium phosphate buffer solution to adjust the solution pH to 6, then adding cellulase (enzyme activity 1500U / g) at a ratio of 1:1000g, heating to 45°C, performing enzymolysis in a constant temperature water bath for 4.5 hours, adding hydrochloric acid at a ratio of 4:1000mL, with a solid-liquid ratio of 1:16, extracting twice, the first time for 1.5 hours and the second time for 1 hour, filtering with a 200-mesh filter cloth, combining the filtrate, and concentrating to 300 mL under reduced pressure at 50°C.

8. The method for preparing an anti-dandruff and oil-controlling composition according to claim 4, characterized in that: In the step 2), the stirring speed is 160-200 r / min, and the heating temperature is 45-55°C.

9. The method for preparing an anti-dandruff and oil-controlling composition according to claim 4, characterized in that: In the step 3), the stirring speed is 900-960 r / min, and the heating temperature is 60-70°C.

10. The method for preparing an anti-dandruff and oil-controlling composition according to claim 4, characterized in that: In the step 4), the stirring speed is 8000-9000 r / min.

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