Application of collateral plexus overexpression in treatment of Alzheimer's disease
Through choroid plexus-specific AAV virus injection, the choroid plexus secretes apoE, solving the problems of low Aβ clearance efficiency and great side effects in existing Alzheimer's treatment methods, achieving efficient clearance of Aβ and relieving pathological progress.
CN119700835APending Publication Date: 2025-03-28CHONGQING MEDICAL UNIVERSITY
0 Cites 0 Cited by
Patent Information
- Application Number
- CN202411890490.7
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2024-12-20
- Publication Date
- 2025-03-28
AI Technical Summary
Technical Problem
The existing Alzheimer's treatment methods have side effects and are difficult to effectively remove β-amyloid (Aβ) in the brain, leading to disease progression.
Method used
Through choroid plexus-specific AAV virus injection, the choroid plexus is synthesized and secreted into cerebrospinal fluid, and its application in the treatment of Alzheimer's disease is explored.
Benefits of technology
This method may provide new therapeutic ideas by regulating the Aβ clearance mechanism in the brain, reducing Aβ spread, thereby alleviating the pathological progress of Alzheimer's disease.
✦ Generated by Eureka AI based on patent content.
Abstract
The invention relates to the technical field of Alzheimer's disease treatment, in particular to application of collateral plexus overexpression in Alzheimer's disease treatment. The application comprises application of collateral plexus overexpression in treatment of Alzheimer's disease; the invention relates to application of venation plexus overexpression in reduction of beta-amyloid protein diffusion. According to the invention, the choice of a special target of the collateral plexus can become a new target for AD treatment, whether apoE synthesized by epithelial cells of the collateral plexus and secreted into cerebrospinal fluid participates in the disease process of AD or not is disclosed, the relation between the apoE of the collateral plexus and brain parenchyma A beta is disclosed, and a new thought can be opened for prevention and treatment of the Alzheimer's disease; according to the method, the influence of apoE4 overexpression and knock-down in the collateral cluster on brain parenchyma A beta is explored, and a new thought is possibly provided for reducing A beta diffusion so as to relieve AD (Alzheimer's disease).
Need to check novelty before this filing date? Find Prior Art