Pharmaceutical composition for cat infectious rhinobronchitis as well as preparation method and application thereof

Abstract

The invention provides a pharmaceutical composition for cat infectious rhinobronchitis as well as a preparation method and application thereof. The pharmaceutical composition provided by the invention is prepared from the following raw materials in parts by weight: 3 to 10 parts of folium artemisiae argyi, 1 to 5 parts of rhizoma atractylodis, 1 to 5 parts of flos magnoliae and 0.5 to 3 parts of rhizoma acori graminei. The preparation method of the pharmaceutical composition provided by the invention comprises the following steps: respectively processing the folium artemisiae argyi, the rhizoma atractylodis, the flos magnoliae and the rhizoma acori graminei into moxa, rhizoma atractylodis powder, flos magnoliae powder and rhizoma acori graminei powder, uniformly stirring and mixing, and further preparing an incense strip. The pharmaceutical composition provided by the invention is administered in a smoking inhalation manner, so that the pharmaceutical components directly act on the upper respiratory tract of a sick cat, the symptoms of rhinitis and nasosinusitis of the sick cat can be effectively controlled, the disease relapse probability is low, the treatment effect and reliability are greatly improved, the treatment cycle is greatly shortened, and excessive use of antibiotics in clinical treatment can be avoided.

Description

Technical Field

[0001] The invention relates to the technical field of veterinary inhalation medicines, and in particular to a medicine composition for feline infectious rhinobronchitis, and a preparation method and application thereof. Background Art

[0002] With the improvement of living standards, the number of pets raised has increased year by year, and pet health and medical issues have gradually received widespread attention from society.

[0003] Feline infectious rhinobronchitis is an infectious disease that is seriously harmful to cats, especially kittens. Its pathogen is feline herpesvirus type I, which poses a serious threat to the health of cats. In the early stage of the disease, cats mainly show symptoms of upper respiratory tract infection. Sick cats appear depressed, anorexia, fever, cough, sneeze, tears, and secretions from the eyes and nose. The secretions are serous at first and become purulent as the disease worsens. Chronic cases may have symptoms such as coughing, sinusitis, and difficulty breathing. The disease is particularly harmful to kittens, with a mortality rate of up to 50%.

[0004] In terms of prevention of the disease, vaccines are the main method; in terms of treatment of sick animals, cat interferon can be injected, and secondary bacterial infections can be treated with antibiotics. However, the vaccine prevention effect of the disease is limited; the treatment effect of interferon is not satisfactory; antibiotics do not target viruses, and long-term use can easily lead to drug resistance. Therefore, even with timely treatment, nearly half of sick cats will develop chronic or latent infections. Once the environment changes, such as a sudden drop in temperature, sick cats may reappear acute symptoms. There is also a method of using aerosol inhalation treatment of adrenal glucocorticoid drugs. Although it can control respiratory inflammatory exudation to a certain extent, it cannot cure the disease, and there are side effects such as reducing the animal's immune ability and consuming the body's material resources. Summary of the invention

[0005] The present invention aims to solve one of the technical problems in the prior art at least to a certain extent. To this end, one object of the present invention is to provide a pharmaceutical composition for feline infectious rhinobronchitis with good efficacy and low side effects.

[0006] In one aspect of the present invention, a pharmaceutical composition for feline infectious rhinobronchitis is provided. The raw materials thereof include, by weight, 3-10 parts of wormwood leaves, 1-5 parts of atractylodes lancea, 1-5 parts of magnolia officinalis, and 0.5-3 parts of calamus tatarinowii.

[0007] The pharmaceutical composition provided by the present invention adopts the above composition and proportion, can effectively treat feline infectious rhinobronchitis, has low side effects, and can effectively reduce recurrence.

[0008] The pharmaceutical composition provided by the present invention has a pungent and bitter taste and is warm in nature. It has the functions of aromatic odor-avoiding and preventing epidemics. The content of cellulose and volatile oil is high, which is convenient for continuous combustion. It plays a major role in the prescription, and is pungent, warm and dispersing, and relieves the cold-dampness attacking the lungs during infectious rhinorrhoea and bronchitis in cats. Atractylodes lancea is pungent and bitter in taste and is warm in nature. It has the functions of drying dampness and strengthening the spleen, dispelling wind and dispersing cold, and helps to improve respiratory mucosal edema, and is a ministerial drug. Acorus calamus is pungent, bitter, slightly warm, and can open the mind and eliminate phlegm, regulate qi and activate blood circulation, dispel wind and dispel dampness, and assist in clearing phlegm and dampness in the respiratory tract, and is an adjuvant. Magnolia officinalis is pungent and warm in taste, and has the functions of dispersing wind and cold and clearing the nasal cavity. It can not only improve the microcirculation state of the respiratory tract, but also lead the medicine into the nasal cavity, and is a guiding drug.

[0009] In some embodiments, the raw materials include, by weight: 3-6 parts of Artemisia argyi, 1-3 parts of Atractylodes macrocephala, 1-3 parts of Magnolia officinalis, and 1-2 parts of Acorus calamus. The pharmaceutical composition provided by the present invention, using such a composition and ratio, can achieve better effects in treating infectious rhinorrhoea and bronchitis in cats, with low side effects, and effectively reduce recurrence.

[0010] In some embodiments, the pharmaceutical composition is in the form of a fumigant; the smoke of the fumigant can directly reach the lesion and can have a rapid and direct therapeutic effect; it has been verified that the smoke of the fumigant has a better therapeutic effect on feline infectious rhinobronchitis.

[0011] In some embodiments, the pharmaceutical composition further comprises 2-8 parts by weight of elm bark powder, which is used as an auxiliary material to act as a binder.

[0012] The second aspect of the present invention provides a method for preparing the aforementioned pharmaceutical composition, comprising: processing wormwood leaf, atractylodes, magnolia and calamus into wormwood floss, atractylodes powder, magnolia powder and calamus powder respectively, and stirring and mixing them evenly; wherein, except for wormwood leaf, the remaining powders are coarse powder-medium powder screened by a 50-80 mesh screen, and after screening, the ash after the medicine is burned is fine, which is conducive to safe operation and convenient cleaning. The powdered pharmaceutical composition can be added to incense burning equipment such as incense burners for fumigation. wherein, the coarse powder refers to powder that can pass through the No. 3 sieve (50 mesh) but is mixed with no more than 20% of powder that can pass through the No. 5 sieve (80 mesh).

[0013] In some embodiments, the particle size of the Atractylodes lancea powder, Magnolia flos powder and Acorus calamus powder is 180-355 μm. By selecting the Atractylodes lancea powder, Magnolia flos powder and Acorus calamus powder within this particle size range, the pharmaceutical composition can be burned more completely.

[0014] In some embodiments, the moxa, atractylodes powder, magnolia powder and calamus powder are evenly mixed, and then mixed with elm bark powder, water is added and stirred, and the mixture is mixed into a mass to form an incense stick. The pharmaceutical composition is made into an incense stick for easy storage, and the aromatherapy drug delivery using an incense stick or incense bundle is simple and convenient to operate, without the need for additional equipment such as an incense burner.

[0015] In some embodiments, the pharmaceutical composition is made into 6-10 incense sticks and combined into an incense bundle to expand the diameter of the smoke column and facilitate drug inhalation.

[0016] The third aspect of the present invention provides use of the pharmaceutical composition and / or the pharmaceutical composition obtained by the preparation method in a drug for preventing and / or treating feline infectious rhinobronchitis.

[0017] In some embodiments, the drug is administered by fumigation, which has a better therapeutic effect.

[0018] In some embodiments, the drug dosage is 2-4 times a day, and each fumigation lasts 10-15 minutes. When the pharmaceutical composition provided by the present invention is used to treat feline infectious rhinobronchitis, the above dosage can be administered to quickly alleviate symptoms and help shorten the course of the disease.

[0019] The present invention has at least the following technical effects: The pharmaceutical composition for treating respiratory tract infection of cats of the present invention has a significant therapeutic effect on respiratory tract infection of pets by rationally formulating traditional Chinese medicine and synergistic action of various components. The composition is mainly used to treat long-standing or irregular respiratory symptoms of infectious rhinorrhoea and bronchitis in cats, such as persistent nasal congestion, dyspnea, sneezing, runny nose and tears (clear and thin nasal discharge, purulent nasal discharge, purulent eye mucus, etc.), and relieves respiratory obstruction. The preparation method of the drug of the present invention is simple, easy to use, and meets the needs of large-scale industrial production.

[0020] Feline infectious rhinobronchitis is a common and intractable disease in pet clinics. Existing treatments mostly rely on interferon and antibiotics, which have limited efficacy and are prone to drug resistance, and the disease is prone to recurrence. Compared with conventional treatments, the present invention adopts non-antibiotic Chinese medicine fumigation therapy. The drug acts directly on the respiratory tract lesions through inhalation, which can effectively improve the symptoms of nasal congestion, sneezing, and nasal discharge in sick cats, promote respiratory tract patency, and has reliable efficacy. Symptoms are not easy to recur after treatment, reducing the use of antibiotics and related side effects, and has higher safety and effectiveness. DETAILED DESCRIPTION

[0021] Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in the field without making any creative work shall fall within the scope of protection of the present invention.

[0022] Feline infectious rhinobronchitis is a clinically refractory disease, which is traditionally treated with interferon, antibiotics, hormones, etc., generally for 5 consecutive days, and cured when the symptoms disappear and there is no recurrence for 2 weeks. However, the above-mentioned therapies have problems such as poor efficacy and obvious side effects. Therefore, one aspect of the present invention provides a pharmaceutical composition for feline infectious rhinobronchitis, which has the advantages of good efficacy, low side effects, and relatively simple operation.

[0023] The pharmaceutical composition provided by the present invention is used to treat infectious rhinorrhoea and bronchitis in cats, and the method of use is fumigation. Each time, the sick cat is placed in an open environment and properly restrained. After the incense bundle is burned, it is placed under the mouth and nose of the sick cat, so that the smoke column goes directly into the nasal cavity. It is kept for a few seconds each time. The sick cat often sneezes after being stimulated (or clear and thin nasal fluid drips from the nostrils), and the head will be moved away to breathe fresh air; after the cat is slightly stable, continue to place the burning incense bundle under the mouth and nose of the sick cat, so that it inhales the smoke and sneezes, and repeat this many times. The whole process lasts for 10-15 minutes, which is a single treatment. The treatment is 2-3 times a day. According to this dosage, the symptoms can be quickly controlled and alleviated, and the course of the disease can be shortened. In the early stage of treatment, the sick cat will continuously discharge the purulent nasal mucus in the nasal cavity with sneezing. After 3-4 days, the symptoms of purulent nasal mucus gradually decrease, and it can generally be used continuously for 1 week. After that, if the symptoms are significantly alleviated but there is still a small amount of sneezing and nasal mucus, the treatment frequency can be reduced to 1-2 times a day, and the treatment is continued until the symptoms disappear, and the drug can be stopped.

[0024] From the analysis of the symptoms and characteristics of infectious rhinobronchitis in cats, it belongs to the syndrome of cold and dampness invading the lungs in traditional Chinese veterinary medicine, and aromatic and filthy avoidance is the traditional rule of traditional Chinese veterinary medicine to prevent and control respiratory infectious diseases. In clinical diagnosis and treatment, it was found that by inhaling the smoke of spicy Chinese medicine formula, the drug ingredients can directly act on the upper respiratory tract of sick cats, which can improve the microcirculation state and help enhance the local defense function. At the same time, it can enhance the secretion of nasal fluid and stimulate the sick cat to sneeze, thereby promoting the discharge of purulent secretions and achieving the purpose of treatment.

[0025] The invention uses wormwood as the basis, formulates a Chinese medicine formula, and prepares a fumigant. The fumigant is administered by burning and then inhaling the fumigant to treat infectious rhinitis and bronchitis in cats, which can effectively control the symptoms of rhinitis and sinusitis, greatly shorten the treatment cycle, and avoid excessive use of antibiotics in clinical treatment. Clinical use shows that after fumigation inhalation treatment, the symptoms of respiratory tract infection in sick cats are significantly alleviated, the probability of recurrence of the disease is low, and the effect and reliability of treatment are greatly improved.

[0026] The present invention is described below with reference to specific embodiments. It should be noted that these embodiments are merely illustrative and do not limit the present invention in any way.

[0027] In the following examples, all raw materials used were purchased from Beijing Tong Ren Tang (Malianwa Pharmacy).

[0028] In the following embodiments, the treatment of infectious rhinitis in cats is used as an example for explanation. When used to prevent infectious rhinitis in cats, it can be directly used on cats. At this time, the medication time or dosage should be appropriately reduced according to the actual situation, such as once every 1-3 days, or 1-2 times a day. It can also act on the environment. At this time, the environment can be disinfected by fumigation to achieve a preventive effect.

[0029] Example 1 The invention provides a pharmaceutical composition for treating infectious rhinobronchitis in cats. The pharmaceutical composition comprises 4g of wormwood leaf, 3g of atractylodes, 2g of magnolia flower, 2g of calamus tatarinowii and 4g of elm bark powder.

[0030] This embodiment also provides a method for preparing the pharmaceutical composition, the steps are as follows: (1) Grind the mugwort leaves into moxa floss according to the formula quantity, and grind the atractylodes, magnolia and calamus into coarse powder together or separately. Evenly mix the moxa floss, moxa residue, atractylodes powder, magnolia powder, calamus powder and elm bark powder. Add appropriate amount of water, stir evenly and mix into a material mass.

[0031] (2) Put the mixed material into an incense making machine and make incense sticks with a diameter of 1-3mm and a length of 6-10cm. Place them in a cool and dry place to dry.

[0032] (3) Roll 6-10 incense sticks into an incense bundle with cotton paper.

[0033] Example 2 The invention provides a pharmaceutical composition for treating infectious rhinorrhoea of ​​cats, which is substantially the same as Example 1, except that the particle sizes of the atractylodes lancea powder, the magnolia flower powder and the calamus tatarinowii powder are controlled to be between 180 and 355 μm by screening with a 10-50 mesh net.

[0034] Example 3 The present invention provides a pharmaceutical composition for treating infectious rhinobronchitis in cats, which is basically the same as Example 1, except that the pharmaceutical composition comprises 8 g of Artemisia argyi, 5 g of Atractylodes lancea, 3 g of Magnolia officinalis, and 2 g of Acorus tatarinowii.

[0035] Comparative Example 1 This comparative example provides a pharmaceutical composition for treating infectious rhinorrhoea in cats, which is basically the same as Example 2, except that the pharmaceutical composition is in the form of an oral powder, and the preparation method is as follows: crushing wormwood leaves into wormwood floss according to the formula amount, crushing atractylodes, magnolia, and calamus into coarse powder together or separately, and mixing with elm bark powder, decocting in water, filtering, and obtaining a 1g / ml decoction. The sick cat takes 0.3ml / kg body weight orally each time, 2-3 times a day.

[0036] Comparative Example 2 This comparative example provides a pharmaceutical composition for treating infectious rhinorrhoea and bronchitis in cats, which is basically the same as Example 2, except that the pharmaceutical composition is in the form of oral pills, and the preparation method is as follows: crushing wormwood leaves into wormwood floss according to the formula amount, crushing atractylodes, magnolia, and calamus into fine powders together or separately, mixing with elm bark powder, adding water to make pills, and making 0.1g / pill water pills. The cat takes 3 pills / kg body weight orally each time, 2-3 times a day.

[0037] Comparison of the effects of treating infectious rhinobronchitis in cats: 1. Related information of comparative test Case inclusion criteria: Naturally occurring cats with symptoms of sneezing, runny nose, and nasal congestion and positive herpes virus tests were selected as verification objects. The specific symptoms were: frequent sneezing, runny nose (nasal discharge characteristics are not limited), a history of positive herpes virus in nasal secretions; or coughing, loss of appetite, etc. There was no limit on age, gender, or previous treatment history.

[0038] 2. Test methods A total of 49 cats that met the above criteria were randomly divided into 7 groups, with 7 cats in each group.

[0039] Test groups 1-3 respectively used the Chinese medicine composition preparations of Examples 1-3 for clinical trial treatment; Test groups 4-5 respectively used the Chinese medicine composition preparations of comparative examples 1-2 for clinical trial treatment; Experimental group 6 uses the existing method of injecting interferon and antibacterial drugs for clinical trial treatment; specifically: cat omega interferon, subcutaneous injection, 150,000 units / kg body weight, once a day, for 5 consecutive days; cefquinome sulfate, subcutaneous injection, 2.5 mg / kg body weight, once a day, for 5 consecutive days. If one course of treatment is not cured, or if the symptoms relapse one week after disappearance, a second course of treatment will be carried out; Experimental group 7 used sick cats whose owners gave up treatment but continued to keep them as a control blank test and did not give them any treatment.

[0040] In Test Examples 1-5, the specific treatment methods are: Place the sick cat in an open environment, secure it appropriately, light the incense bundle and place it under the cat's mouth and nose, so that the smoke column goes straight into the nasal cavity, and keep it for a few seconds each time. The sick cat often sneezes after being stimulated (or clear nasal fluid drips from the nostrils), and will move its head away to breathe fresh air; after the cat is slightly stable, continue to place the burning incense bundle under the cat's mouth and nose, so that it inhales the smoke and sneezes, and repeat this many times. The whole process lasts 10-15 minutes, which is a single treatment, and the treatment is 2-3 times a day for 1 week. After that, if the symptoms are significantly alleviated but there is still a small amount of sneezing and nasal discharge, the treatment frequency can be reduced to 1-2 times a day, and the treatment is continued until the symptoms disappear, then the drug can be stopped. The treatment is generally up to 3 weeks.

[0041] Criteria for judging cure or ineffectiveness: if spontaneous sneezing stops, runny nose disappears, nasal ventilation is smooth, and there is no recurrence within 3 months after the symptoms disappear, it is considered cured; if there is no significant improvement in symptoms within 4 weeks of treatment, or if the symptoms recur within 3 months after stopping the medication, it is considered ineffective.

[0042] 3. Test results The results of the above clinical trial treatment are shown in Table 1 below.

[0043] Table 1 Comparison of results of clinical trial treatment in each group

[0044] From the results in Table 1, it can be seen that the cure rate of the Chinese medicine composition preparation of the present invention for treating infectious rhinobronchitis in cats can reach more than 77% (up to 100%), which is significantly higher than the therapeutic effect of the existing conventional injection of interferon and antibiotics (57.1% cure rate), and the corresponding medication course is also shorter than the existing conventional injection of interferon and antibiotics.

[0045] It has been verified that the therapeutic effect of oral powder is significantly worse than that of fumigants. Although the embodiments do not provide specific examples, it has been verified that the therapeutic effects of not only powders but also other oral dosage forms are significantly worse than those of fumigants.

[0046] Typical application cases In the following typical cases, the pharmaceutical composition obtained in Example 1 was administered.

[0047] Application Example 1 Tabby cat, male, 5 months old, weight 1.9kg, not immunized.

[0048] Continuous sneezing began 4 weeks ago, which worsened when exposed to wind and cold. Occasionally, nasal mucus spurted out, the clearness was uncertain, and the nose was blocked. At night, the nasal breathing sounds could be clearly heard to be aggravated; the conjunctiva of the eyes was red, and there was a small amount of purulent secretion. The appetite worsened after the onset of the disease. The herpes virus was positive by PCR test. After tracheal lavage and nasal secretion culture 2 weeks ago, no colonies were found in the tracheal lavage fluid, while multiple colonies were produced in the nasal secretions. Antibiotics were used for treatment based on the results of the drug sensitivity test, and feline interferon was given continuously for 5 days. The symptoms improved in the first 3-4 days, and then gradually worsened and returned to the state before medication. After 2 weeks of continuous treatment without effect, the patient was transferred to the Chinese veterinary clinic. When he came to the clinic, his weight had dropped slightly compared to before the onset of the disease. Auscultation of the lungs revealed clear breath sounds and the tongue was pale.

[0049] The present invention was used to treat this case. The sick cat was placed in a cage net to limit its range of activities. The incense bundle was burned and placed under the mouth and nose of the sick cat, so that the smoke column went straight into the nasal cavity and was kept for 1-3 seconds. The sick cat sneezed and sprayed a large amount of yellow-brown purulent secretions at the same time. The fumigation was continued for 15 minutes each time. The sick cat sneezed more than ten times, and the amount of purulent mucus sprayed gradually decreased. Finally, a small amount of clear and thin nasal fluid dripped from the nostrils. Treat 3 times a day as above. After the first day of treatment, the sick cat had a reduced frequency of spontaneous sneezes, and the nasal congestion was significantly relieved that night. There was more purulent mucus around the nostrils within 3 days, and then the face gradually began to clean, and the appetite was significantly enhanced. After 1 week of continuous treatment, the sick cat no longer had spontaneous sneezes, the redness and swelling of the conjunctiva subsided, and there was no purulent eye mucus. The owner continued to fumigate 1-2 times a day for 1 week, and the symptoms disappeared completely. The treatment was then stopped.

[0050] No recurrence was observed during the 8-month follow-up.

[0051] Application Example 2 Chinese rural cat, male castrated, 1 year old, weighing 4.5kg, immunized. Usually can go out and move freely.

[0052] Sneezing occurred 3 months ago. Initially, the nasal discharge was clear and thin, and the eyes were red and tearful. After 2 weeks, it turned into yellow-green purulent discharge. After 2 months, the discharge gradually became clear and thin, but the nasal congestion worsened and has lasted until now. At present, the nasal cavity is blocked all day long. The sick cat has difficulty breathing and a large breathing amplitude. It is common to see a small amount of clear discharge hanging in the nostrils. The sneezing worsens when it is cold. When sneezing is frequent, blood is occasionally seen in the discharge, and purulent discharge occasionally spurts out. At present, the conjunctival symptoms are no longer obvious and the appetite is normal. The herpes virus test was positive at the beginning of the disease. Three courses of cat interferon were injected, and famciclovir, doxycycline, and tobramycin eye drops were taken.

[0053] The present invention is used for treatment. Each time the owner picks up the sick cat, secures it with bare hands, and places the burning incense bundle under the sick cat's mouth and nose, so that the smoke column goes directly into the nasal cavity. It needs to be kept for about 10 seconds in the initial stage, so that the sick cat can sneeze and spray yellow-green purulent mucus at the same time. Each time the fumigation treatment is continued for 10-15 minutes, so that the sick cat sneezes more than ten times, and the treatment is done twice a day. Within 5 days after the start of treatment, the sick cat continuously sprays yellow-green purulent mucus during each treatment; after the third day of treatment, the nasal sound becomes significantly lighter, and the breathing movement becomes stable and smooth; after 1 week of treatment, the frequency of spontaneous sneezing is significantly reduced, and each time the spray is only a small amount of clear mucus, and the yellow-green thick and turbid character is no longer seen. After 2 weeks of continuous treatment, the symptoms basically disappear. After that, the owner performs fumigation treatment irregularly, with a frequency of about once every 2-3 days, and the symptoms completely disappear in about 3 weeks. The owner continues to use the medicine for 2 months and then stops.

[0054] No recurrence was observed during the 6-month follow-up.

[0055] Application Example 3 Exotic shorthair cat, male, 3 years old, weighing 2.5kg, thin, immunized twice at 3 months old, and no booster immunization was performed afterwards.

[0056] Shortly after the family bought an American Shorthair cat one and a half years ago, both cats began to sneeze, have runny noses, and tear. After testing, both cats were positive for herpes virus. After treatment with interferon and antibiotics, the American Shorthair cat recovered in 2 weeks. This cat continued to receive treatment for 2 months, but the symptoms have not been effectively relieved. The sneezing continues to this day, and the nasal cavity has long secreted white nasal discharge, the eyes are sometimes photophobic, and the tears increase. Since the onset of the disease, the sick cat has lost its appetite, become listless, and has significantly reduced autonomous activities. It likes to curl up in a warm place, has obvious nasal congestion at night, and has aggravated sneezing in the early morning. In the past year, the owner has not taken active treatment, and only used antibiotics when the nasal congestion was particularly severe and accompanied by coughing. Each treatment cycle is 1-2 weeks. Six months after the onset of the disease, the herpes virus test was performed again, and it was negative. A cold wave hit three days ago, and the owner did not pay attention to closing the window when he went out. After catching a cold, the sick cat sneezed significantly more, had severe nasal congestion, and breathed with its mouth open from time to time. The nasal discharge changed from white to clear and thin, and was accompanied by phlegm and cough, which was lighter during the day and heavier at night, but the cough was weaker.

[0057] According to the course of the disease and the characteristics of symptoms, the Chinese veterinary medicine syndrome differentiation is that the wind-cold binds the lungs, and there is phlegm and dampness inside. The treatment adopts the present invention, and is taken orally with Tongxuan Lifei Pills and Tongqiao Rhinitis Tablets. Because the sick cat is depressed, the owner does not make strong restraint. He comforts the sick cat by stroking it every time, and places the burning incense bundle next to the mouth and nose of the sick cat, so that it inhales the smoke when breathing, and lasts for 10 minutes each time, 3 times a day. The sick cat sneezes after inhaling the smoke, but the initial sneezing is weak. After 2-3 days of fumigation treatment and oral medication, the sick cat's cough becomes loud, and sputum can be coughed up every time, and the sneezing also becomes powerful, and a large amount of white turbid sticky mucus can be sprayed out. After 7 days of treatment, the coughing basically stops, the sneezing is significantly reduced, the sick cat's spirit and appetite are improved, and the autonomous activity increases. The oral medication is discontinued after 10 days of continuous use. The fumigation therapy continues to be used for 2 weeks. The sick cat still has nasal congestion when breathing, but the sneezing and nasal discharge have disappeared. The owner then changed to fumigation once a day on average for 2 weeks.

[0058] The cat was followed up for 1 year. During this period, the cat had a recurrence of sneezing when the weather changed. The owner fumigated the cat for a few days and the symptoms disappeared, and the treatment was stopped.

[0059] No recurrence of sneezing and runny nose was observed during the 6-month follow-up, but the nasal sound was still obvious. The reason was analyzed to be related to the tissue hyperplasia of the nasal mucosa after long-term rhinitis, and also related to the inherent structural characteristics of the nasal cavity of the exotic shorthair cat breed.

[0060] Application Example 4 Chinese rural cat, male, 3 years old, weight 4kg, not immunized.

[0061] Three weeks ago, a stray kitten was taken in by the family for several days. Ten days later, the cat began to be mentally fatigued, feverish, and sneezed frequently. The owner continuously monitored its body temperature, which was between 39.3℃-39.8℃ for several days. The fever subsided after one week, and it has been back to normal for 5 days. The sneezing is still frequent, especially in the early morning, and a small amount of clear mucus is sprayed out every time. The herpes virus test was positive when it came to the clinic. The owner did not use interferon or antibiotics for treatment, and requested to directly use Chinese veterinary methods.

[0062] The present invention was used for treatment. The owner tried to restrain the sick cat with his bare hands or with a cage, but the cat resisted restraint. In addition, the owner went out early and came back late every day, making it difficult to guarantee the frequency of fumigation. Therefore, he changed it to lighting several incense bundles of the present invention in the toilet every night, so that the smoke in the toilet reached a higher concentration, and then placed the cat in the toilet, closed the door, let the cat inhale the smoke, and placed the cat in the toilet overnight. After 1 week of continuous treatment, the sick cat almost did not sneeze spontaneously. The owner continued the treatment as above for 10 days, and the sneezing symptoms completely disappeared.

[0063] During the 4-month follow-up, no recurrence of respiratory symptoms was observed.

[0064] Application Example 5 Russian Blue cat, male, 4 months old, weight 1.5kg, not immunized.

[0065] The cat was bought by the owner when it was 3 months old. On the same day, it was observed to sneeze occasionally, which gradually became more frequent within a few days, with clear and thin nasal discharge. It was examined at the veterinary hospital and found to be positive for herpes virus. Interferon and antibiotics have been used for 3 weeks. In the first week of treatment, the symptoms were alleviated to a certain extent, and then gradually worsened, and the conjunctiva was red and swollen, and both eyes were shy and tearful. Loss of appetite and physique became thinner. When the sick cat came to the clinic, the nasal cavity was severely blocked, and it sometimes breathed with its mouth open. The third eyelid of the left eye was swollen, covering 1 / 3 of the eyeball, and the cornea was slightly turbid.

[0066] The previous treatment plan was discontinued, and the present invention was used for treatment instead. The sick cat was restrained by hand, and the burning incense bundle was placed under the sick cat's mouth and nose. It was kept for a few seconds and then removed to allow the cat to breathe fresh air, and this was repeated. The fumigation was continued for 15 minutes each time, and the treatment was done 3 times a day. During the initial few treatments, the sick cat sometimes opened its mouth to breathe, and relatively less smoke entered the nasal cavity, while relatively more smoke entered the oral cavity, resulting in mild drooling. After 1 day, the sick cat's nasal ventilation improved, and mouth breathing was significantly reduced, and drooling no longer occurred during the treatment. After 1 week of treatment, the sick cat's nasal ventilation returned to normal, spontaneous sneezing basically disappeared, conjunctival redness and swelling subsided, the third eyelid retracted to a slightly protruding state, and the cornea returned to transparency. The frequency of treatment was reduced to 1-2 times per day, and the treatment was continued for 5 days until the symptoms completely disappeared.

[0067] After 1-year follow-up, no recurrence of respiratory symptoms was observed.

[0068] In summary, infectious rhinobronchitis in cats is a common and difficult-to-treat disease in clinic. The traditional method of combining interferon with antibiotics has a certain therapeutic effect, but the condition often relapses; the pharmaceutical composition provided by the present invention can effectively treat infectious rhinobronchitis in cats, and the operation is simple and convenient; the administration method of fumigation inhalation directly allows the drug to act locally on the respiratory mucosa, which can effectively control the symptoms of rhinitis and sinusitis, with reliable efficacy, and the symptoms are not easy to recur after treatment, reducing the use of antibiotics and related side effects, and having higher safety and effectiveness; greatly shortening the treatment cycle. However, the above-mentioned drug combination is decocted or made into pills for oral administration, which does not focus enough on the local nasal cavity, so the efficacy is not as good as fumigation inhalation.

[0069] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, rather than to limit it. Although the present invention has been described in detail with reference to the aforementioned embodiments, those skilled in the art should understand that they can still modify the technical solutions described in the aforementioned embodiments, or make equivalent replacements for some of the technical features therein. However, these modifications or replacements do not deviate the essence of the corresponding technical solutions from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A pharmaceutical composition for feline infectious rhinobronchitis, characterized in that: Calculated by weight, the raw materials include: 3-10 parts of mugwort leaves, 1-5 parts of atractylodes, 1-5 parts of magnolia, and 0.5-3 parts of calamus.

2. The pharmaceutical composition according to claim 1, characterized in that Calculated by weight, the raw materials include: 3-6 parts of mugwort leaves, 1-3 parts of atractylodes, 1-3 parts of magnolia, and 1-2 parts of calamus.

3. The pharmaceutical composition according to claim 1 or 2, characterized in that The dosage form of the pharmaceutical composition is a fumigant.

4. The pharmaceutical composition according to any one of claims 1 to 3, characterized in that According to its weight percentage, it also includes 2-8 parts of elm bark powder.

5. The method for preparing the pharmaceutical composition according to claims 1-4, characterized in that: include: Process wormwood, atractylodes, magnolia and calamus into wormwood fluff, atractylodes powder, magnolia powder and calamus powder respectively, and stir and mix them evenly.

6. The preparation method according to claim 5, characterized in that: The particle sizes of the atractylodes powder, magnolia powder and calamus powder are 180-355 μm.

7. The preparation method according to claim 5 or 6, characterized in that: The moxa, atractylodes powder, magnolia powder and calamus powder are evenly mixed, then evenly mixed with elm bark powder, water is added and stirred, and the mixture is adjusted into a mass to make incense sticks.

8. The preparation method according to claim 5 or 6, characterized in that: The pharmaceutical composition is made into 6-10 incense sticks and combined into an incense bundle.

9. Use of the pharmaceutical composition according to any one of claims 1 to 4 and / or the pharmaceutical composition obtained by the preparation method according to any one of claims 5 to 8 in a drug for preventing and / or treating feline infectious rhinobronchitis.

10. The use according to claim 9, characterized in that: The drug is administered by fumigation.

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