Traditional Chinese medicine composition for treating uterine tissue related diseases and preparation method thereof

Abstract

The invention relates to the technical field of traditional Chinese medicine compositions. The invention provides a traditional Chinese medicine composition for treating uterine tissue related diseases and a preparation method thereof. The traditional Chinese medicine composition comprises the following components: Chinese yam, codonopsis pilosula, bighead atractylodes rhizome, semen cuscutae, glossy privet fruit, lotus seed pulp, parasitic loranthus, rhizoma smilacis glabrae, coix seed, selfheal, kelp, seaweed, cassia twig and bulbus fritillariae cirrhosae. The compatibility of the medicinal components can improve the symptoms of uterine tissue related diseases such as hysteromyoma, adenomyoma and cervical cyst, and reduce the volume of myoma or cyst; meanwhile, the selected materials are safe, non-toxic and sustainable to take.

Description

Technical Field

[0001] The present invention relates to the technical field of Chinese medicine compositions, and in particular to a Chinese medicine composition for treating uterine tissue-related diseases and a preparation method thereof. Background Art

[0002] Uterine-related diseases mainly include uterine inflammation, endometrial disease, intrauterine foreign bodies, congenital uterine diseases, uterine tumors, etc. Among them, uterine fibroids are benign tumors, which are benign hyperplasias from uterine smooth muscle tissue, mainly affecting women aged 30-50. The cause of the disease has not yet been determined, and it may be related to genetic susceptibility, sex hormone levels and stem cell dysfunction. The incidence rate is difficult to accurately calculate, and it is estimated that the prevalence rate in women of childbearing age may reach 25%. Among them, the main treatment methods for patients with prominent symptoms currently include drug therapy and surgical treatment. The drugs are mainly gonadotropin-releasing hormone drugs, non-steroidal anti-inflammatory drugs, hemostatic drugs, combined oral contraceptives, etc., which are used to improve symptoms and reduce the size of fibroids, but the use of drugs has clear side effects. Surgical treatment is suitable for patients whose symptoms have affected their quality of life.

[0003] In summary, it is very necessary to obtain a formula that can effectively act on patients with symptomatic and asymptomatic uterine diseases and has low toxic and side effects. Summary of the invention

[0004] The purpose of the present invention is to provide a traditional Chinese medicine composition for treating uterine tissue related diseases. The combination of the medicinal components of the present invention can improve the symptoms of uterine tissue related diseases such as uterine fibroids, adenomyomas and cervical cysts, and reduce the volume of fibroids or cysts; at the same time, the materials are safe, non-toxic, and can be taken continuously.

[0005] In order to achieve the above-mentioned object of the invention, the present invention provides the following technical solutions:

[0006] The invention provides a traditional Chinese medicine composition for treating uterine fibroids. The composition comprises the following components in parts by weight: 18-23 parts of yam, 12-17 parts of codonopsis pilosula, 12-17 parts of atractylodes macrocephala, 13-18 parts of dodder seeds, 13-17 parts of glossy privet fruits, 8-13 parts of lotus seeds, 7-12 parts of parasitic plants, 7-13 parts of smilax glabra, 5-15 parts of coix seeds, 8-13 parts of selfheal, 8-12 parts of kelp, 7-12 parts of seaweed, 8-12 parts of cassia twig and 4-8 parts of fritillaria cirrhosa.

[0007] Preferably, the following components are included in parts by weight: 19-22 parts of yam, 13-16 parts of Codonopsis pilosula, 13-16 parts of Atractylodes macrocephala, 14-17 parts of Cuscuta australis, 14-16 parts of Ligustrum lucidum, 8.5-12 parts of lotus seed, 8-11 parts of Viscum album, 8-12.5 parts of Smilax glabra, 6-12 parts of Coix seeds, 9-11 parts of Prunella vulgaris, 9-11 parts of Kelp, 8-11 parts of Sargassum, 9-11 parts of Cassia twig and 5-7 parts of Fritillaria cirrhosa.

[0008] The present invention also provides a method for preparing the Chinese medicine composition, which is characterized by comprising the following steps:

[0009] (1) mixing the components, soaking and boiling them in water, and filtering to obtain a filter residue and a filtrate A;

[0010] (2) mixing the filter residue with water, boiling again and filtering to obtain filtrate B;

[0011] (3) Mix filtrate A and filtrate B to obtain.

[0012] Preferably, the amount of water added in step (1) is 2-4 times the total mass of the components.

[0013] Preferably, the soaking time in step (1) is 25-35 minutes.

[0014] Preferably, the decocting in step (1) and the re-decocting in step (2) are both performed by decocting until the water boils and then switching to medium heat for further decocting; the further decocting time is 15-25 minutes.

[0015] The present invention also provides application of the traditional Chinese medicine composition in preparing medicines for treating diseases related to uterine tissue.

[0016] Preferably, the uterine tissue related diseases include uterine fibroids, adenomyomas and cervical cysts.

[0017] Preferably, the dosage form of the drug for treating uterine tissue-related diseases includes powder, granules, tablets or decoction.

[0018] The invention also provides litchi sparkling wine prepared by the preparation method.

[0019] By adopting the above technical solution, the present invention has the following beneficial effects:

[0020] The technical solution of the present invention is based on the results of uterine B-ultrasound examination, and uses traditional Chinese medicine methods to strengthen the spleen and regulate qi, soften and dissipate stagnation, and tonify the kidney and promote yang. The Chinese yam, Codonopsis pilosula, and Atractylodes macrocephala are selected for coordinated compatibility. Codonopsis pilosula, Atractylodes macrocephala, and Coix seeds are used to strengthen the spleen and replenish qi as the main medicine; Smilax glabra, Herba Prunellae, Kelp, Sargassum, and Fritillaria cirrhosae are used to soften and dissipate stagnation and reduce swelling as the ministerial medicine; Cuscuta chinensis, Fructus Ligustri Lucidi, Lotus seed meat, and Morus alba are used to tonify the liver and kidney as adjuvant medicines; Cinnamon twig and Chinese yam are used to promote yang and replenish qi as the guiding medicine. The prescription can effectively improve the symptoms of uterine tissue-related diseases such as uterine fibroids, adenomyoma, and cervical cysts, reduce the volume of fibroids or cysts, and improve the quality of life of patients at the same time. In addition, the present invention is safe in material selection, non-toxic, and can be taken continuously. Although the medication time is long, it can improve the body function more comprehensively and repair uterine tissue more systematically. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 The results of patient Cheng*Ling before and after treatment ( Figure 1 A is before treatment, and B is after treatment);

[0022] Figure 2 The results of patient Ding*Rong before and after treatment ( Figure 2 A is before treatment, and B is after treatment);

[0023] Figure 3 The results of patient Li*Li before and after treatment ( Figure 3 A is before treatment, B is during treatment, and C is after treatment);

[0024] Figure 4 Results of patient Lin* before and after treatment ( Figure 4 A is before treatment, B is during treatment, and C is after treatment);

[0025] Figure 5 The results of the patient Luo*ying before and after treatment ( Figure 5 A is before treatment, and B is after treatment);

[0026] Figure 6 The results of the patient's horse* flower treatment before and after ( Figure 6 A is before treatment, and B is after treatment). DETAILED DESCRIPTION

[0027] The invention provides a traditional Chinese medicine composition for treating diseases related to uterine tissue, comprising yam, codonopsis pilosula, atractylodes macrocephala, dodder seed, glossy privet fruit, lotus seed pulp, parasitic plant, smilax glabra, coix seed, selfheal, kelp, seaweed, cassia twig and fritillaria cirrhosa.

[0028] In the present invention, the weight portion of the yam is preferably 18-23 parts, further preferably 19-22 parts, and further preferably 20 parts; the weight portion of the codonopsis is preferably 12-17 parts, further preferably 13-16 parts, and further preferably 15 parts; the weight portion of the atractylodes is preferably 12-17 parts, further preferably 13-16 parts, and further preferably 15 parts; the weight portion of the dodder is preferably 13-18 parts, further preferably 14-17 parts, and further preferably 15 parts; the weight portion of the privet fruit is preferably 13-17 parts, further preferably 14-16 parts, and further preferably 15 parts; the weight portion of the lotus seed is preferably 8-13 parts, further preferably 8.5-12 parts, and further preferably 10 parts; the weight portion of the mistletoe is preferably 7-12 parts, further preferably 8-11 parts, and further preferably 15 parts. The preferred amount of the step is 10 parts; the weight portion of the Smilax glabra is preferably 7-13 parts, further preferably 8-12.5 parts, and further preferably 10 parts; the weight portion of the Coix seed is preferably 5-15 parts, further preferably 6-12 parts, and further preferably 10 parts; the weight portion of the Prunella vulgaris is preferably 8-13 parts, further preferably 9-11 parts, and further preferably 10 parts; the weight portion of the kelp is preferably 8-12 parts, further preferably 9-11 parts, and further preferably 10 parts; the weight portion of the seaweed is preferably 7-12 parts, further preferably 8-11 parts, and further preferably 10 parts; the weight portion of the cassia twig is preferably 8-12 parts, further preferably 9-11 parts, and further preferably 10 parts; the weight portion of the Fritillaria cirrhosa is preferably 4-8 parts, further preferably 5-7 parts, and further preferably 6 parts.

[0029] The present invention also provides a method for preparing the Chinese medicine composition, comprising the following steps:

[0030] (1) mixing the components, soaking and boiling them in water, and filtering to obtain a filter residue and a filtrate A;

[0031] (2) mixing the filter residue with water, boiling again and filtering to obtain filtrate B;

[0032] (3) Mix filtrate A and filtrate B to obtain.

[0033] In the present invention, yam, codonopsis, atractylodes, dodder seed, Ligustrum lucidum, lotus seed meat, parasitic loquat, smilax glabra, coix seed, selfheal, kelp, seaweed, cassia twig and cirrhosa are selected and mixed, and then soaked in water. The amount of water added in the present invention is preferably 2-4 times the total mass of each component, further preferably 2.5-3.5 times, and further preferably 3 times; the soaking time is preferably 25-35min, further preferably 28-32min, and further preferably 30min.

[0034] In the present invention, the decocting process is performed after the soaking is completed. The decocting method is preferably to boil the water and then switch to medium heat to continue decocting. The decocting time is preferably 15-25 minutes, more preferably 18-22 minutes, and further preferably 20 minutes.

[0035] In the present invention, filtering is performed after the decoction is completed to obtain filter residue and filtrate A.

[0036] In the present invention, water is added to the obtained filter residue for re-decocting, and the amount of water added is 1-3 times the total mass of the raw materials of each component, more preferably 1.5-2.5 times, and more preferably 2 times. The method of re-decocting in the present invention is also preferably to boil until the water boils and then turn to medium heat to continue decocting, and the time for continued decocting is preferably 15-25 minutes, more preferably 18-22 minutes, and more preferably 20 minutes.

[0037] In the present invention, filtering is performed after the second decoction is completed to obtain filtrate B.

[0038] In the present invention, the filtrate A is mixed with the filtrate B to obtain the traditional Chinese medicine composition.

[0039] The present invention also provides application of the traditional Chinese medicine composition in preparing medicines for treating diseases related to uterine tissue.

[0040] In the present invention, the uterine tissue related diseases include uterine fibroids, adenomyomas and cervical cysts.

[0041] In the present invention, the dosage form of the drug for treating uterine tissue-related diseases includes powder, granules, tablets or decoction.

[0042] The technical solutions provided by the present invention are described in detail below in conjunction with the embodiments, but they should not be construed as limiting the protection scope of the present invention.

[0043] Example 1

[0044] A Chinese medicine composition for treating uterine fibroids, comprising the following components:

[0045] 20 parts of yam, 15 parts of codonopsis pilosula, 15 parts of atractylodes macrocephala, 15 parts of dodder seeds, 15 parts of glossy privet fruits, 10 parts of lotus seeds, 10 parts of parasitic loranthus, 10 parts of smilax glabra, 10 parts of coix seeds, 10 parts of selfheal, 10 parts of kelp, 10 parts of seaweed, 10 parts of cassia twig and 6 parts of fritillaria cirrhosa.

[0046] Example 2

[0047] A Chinese medicine composition for treating uterine fibroids, comprising the following components:

[0048] 18 parts of yam, 17 parts of codonopsis pilosula, 12 parts of atractylodes macrocephala, 13 parts of dodder seeds, 13 parts of glossy privet fruits, 8 parts of lotus seeds, 12 parts of parasitic loranthus, 13 parts of smilax glabra, 5 parts of coix seeds, 8 parts of selfheal, 12 parts of kelp, 7 parts of seaweed, 12 parts of cassia twig and 4 parts of fritillaria cirrhosa.

[0049] Example 3

[0050] A Chinese medicine composition for treating uterine fibroids, comprising the following components:

[0051] 23 parts of yam, 12 parts of codonopsis pilosula, 17 parts of atractylodes macrocephala, 18 parts of dodder seeds, 17 parts of glossy privet fruits, 13 parts of lotus seeds, 7 parts of parasitic plants, 7 parts of smilax glabra, 15 parts of coix seeds, 13 parts of selfheal, 8 parts of kelp, 12 parts of seaweed, 8 parts of cassia twig and 8 parts of fritillaria cirrhosa.

[0052] Example 4

[0053] A Chinese medicine composition for treating uterine adenomyoma, comprising the following components:

[0054] 18 parts of yam, 15 parts of codonopsis pilosula, 15 parts of atractylodes macrocephala, 18 parts of dodder seeds, 15 parts of glossy privet fruits, 10 parts of lotus seeds, 7 parts of parasitic loranthus, 10 parts of smilax glabra, 10 parts of coix seeds, 13 parts of selfheal, 10 parts of kelp, 10 parts of seaweed, 10 parts of cassia twig and 6 parts of fritillaria cirrhosa.

[0055] Example 5

[0056] A Chinese medicine composition for treating cervical cysts, comprising the following components:

[0057] 23 parts of yam, 12 parts of codonopsis pilosula, 15 parts of atractylodes macrocephala, 15 parts of dodder seeds, 13 parts of glossy privet fruits, 10 parts of lotus seeds, 10 parts of parasitic loranthus, 7 parts of smilax glabra, 10 parts of coix seeds, 10 parts of selfheal, 10 parts of kelp, 12 parts of seaweed, 10 parts of cassia twig and 8 parts of fritillaria cirrhosa.

[0058] Example 6

[0059] A method for preparing the Chinese medicine composition for treating uterine fibroids as described in Example 1 comprises the following steps:

[0060] (1) Mix the Chinese yam, codonopsis pilosula, atractylodes macrocephala, dodder seed, glossy privet fruit, lotus seed pulp, mistletoe, smilax glabra, coix seed, selfheal, kelp, seaweed, cassia twig and fritillaria cirrhosa in the amounts described in Example 1, soak in water for 30 minutes, the amount of water added being 3 times the total mass of the raw materials of each component; then boil until the water boils, turn to medium heat and continue boiling for 20 minutes, and then filter to obtain a residue and a filtrate A;

[0061] (2) adding water to the obtained filter residue in an amount of twice the total mass of the raw materials of each component, and then boiling the mixture until the water boils, then turning to medium heat and continuing to boil for 20 minutes, and then filtering to obtain filtrate B;

[0062] (3) Mixing the filtrate A and the filtrate B to obtain the Chinese medicine composition.

[0063] Example 7

[0064] A method for preparing the Chinese medicine composition for treating uterine fibroids as described in Example 1 comprises the following steps:

[0065] (1) Mix the Chinese yam, codonopsis pilosula, atractylodes macrocephala, dodder seed, glossy privet fruit, lotus seed pulp, mistletoe, smilax glabra, coix seed, selfheal, kelp, seaweed, cassia twig and fritillaria cirrhosa in the amounts described in Example 1, soak in water for 25 minutes, the amount of water added being twice the total mass of the raw materials of each component; then boil until the water boils, turn to medium heat and continue boiling for 25 minutes, and then filter to obtain a residue and a filtrate A;

[0066] (2) adding water to the obtained filter residue in an amount of 3 times the total mass of the raw materials of each component, and then boiling the mixture until the water boils, then turning to medium heat and continuing to boil for 15 minutes, and then filtering to obtain filtrate B;

[0067] (3) Mixing the filtrate A and the filtrate B to obtain the Chinese medicine composition.

[0068] Example 8

[0069] A method for preparing the Chinese medicine composition for treating uterine fibroids as described in Example 1 comprises the following steps:

[0070] (1) Mix the Chinese yam, codonopsis, atractylodes, dodder seed, glossy privet fruit, lotus seed, mistletoe, smilax, coix seed, selfheal, kelp, seaweed, cassia twig and fritillaria cirrhosa in the amounts described in Example 1, soak in water for 35 minutes, the amount of water added being 4 times the total mass of the raw materials of each component; then boil until the water boils, turn to medium heat and continue boiling for 15 minutes, and then filter to obtain a residue and a filtrate A;

[0071] (2) adding water to the obtained filter residue, the amount of water added being 1.5 times the total mass of the raw materials of each component, and then boiling in the same manner until the water boils, then switching to medium heat and continuing to boil for 25 minutes, and then filtering to obtain filtrate B;

[0072] (3) Mixing the filtrate A and the filtrate B to obtain the Chinese medicine composition.

[0073] Example 9

[0074] A method for preparing the Chinese medicine composition for treating uterine fibroids as described in Example 2 comprises the following steps:

[0075] (1) Mix the Chinese yam, codonopsis pilosula, atractylodes macrocephala, dodder seed, glossy privet fruit, lotus seed pulp, mistletoe, smilax glabra, coix seed, selfheal, kelp, seaweed, cassia twig and fritillaria cirrhosa in the amounts described in Example 2, soak in water for 30 minutes, and add water in an amount of 3 times the total weight of the raw materials of each component; then boil until the water boils, turn to medium heat and continue boiling for 20 minutes, and then filter to obtain a residue and a filtrate A;

[0076] (2) adding water to the obtained filter residue in an amount of twice the total mass of the raw materials of each component, and then boiling the mixture until the water boils, then turning to medium heat and continuing to boil for 20 minutes, and then filtering to obtain filtrate B;

[0077] (3) Mixing the filtrate A and the filtrate B to obtain the Chinese medicine composition.

[0078] Example 10

[0079] A method for preparing the Chinese medicine composition for treating uterine fibroids as described in Example 3 comprises the following steps:

[0080] (1) Mix the Chinese yam, codonopsis pilosula, atractylodes macrocephala, dodder seed, glossy privet fruit, lotus seed pulp, parasitic plant, smilax glabra, coix seed, selfheal, kelp, seaweed, cassia twig and fritillaria cirrhosa in the amounts described in Example 3, soak in water for 30 minutes, and add water in an amount of 3 times the total weight of the raw materials of each component; then boil until the water boils, turn to medium heat and continue boiling for 20 minutes, and then filter to obtain a residue and a filtrate A;

[0081] (2) adding water to the obtained filter residue in an amount of twice the total mass of the raw materials of each component, and then boiling the mixture until the water boils, then turning to medium heat and continuing to boil for 20 minutes, and then filtering to obtain filtrate B;

[0082] (3) Mixing the filtrate A and the filtrate B to obtain the Chinese medicine composition.

[0083] Embodiment 11

[0084] A method for preparing the Chinese medicine composition for treating uterine adenomyoma described in Example 4 comprises the following steps:

[0085] (1) Mix the Chinese yam, codonopsis pilosula, atractylodes macrocephala, dodder seed, glossy privet fruit, lotus seed pulp, mistletoe, smilax glabra, coix seed, selfheal, kelp, seaweed, cassia twig and fritillaria cirrhosa in the amounts described in Example 1, soak in water for 30 minutes, the amount of water added being 3 times the total mass of the raw materials of each component; then boil until the water boils, turn to medium heat and continue boiling for 20 minutes, and then filter to obtain a residue and a filtrate A;

[0086] (2) adding water to the obtained filter residue in an amount of twice the total mass of the raw materials of each component, and then boiling the mixture until the water boils, then turning to medium heat and continuing to boil for 20 minutes, and then filtering to obtain filtrate B;

[0087] (3) Mixing the filtrate A and the filtrate B to obtain the Chinese medicine composition.

[0088] Example 12

[0089] A method for preparing the Chinese medicine composition for treating cervical cysts according to Example 5 comprises the following steps:

[0090] (1) Mix the Chinese yam, codonopsis pilosula, atractylodes macrocephala, dodder seed, glossy privet fruit, lotus seed pulp, mistletoe, smilax glabra, coix seed, selfheal, kelp, seaweed, cassia twig and fritillaria cirrhosa in the amounts described in Example 1, soak in water for 30 minutes, the amount of water added being 3 times the total mass of the raw materials of each component; then boil until the water boils, turn to medium heat and continue boiling for 20 minutes, and then filter to obtain a residue and a filtrate A;

[0091] (2) adding water to the obtained filter residue in an amount of twice the total mass of the raw materials of each component, and then boiling the mixture until the water boils, then turning to medium heat and continuing to boil for 20 minutes, and then filtering to obtain filtrate B;

[0092] (3) Mixing the filtrate A and the filtrate B to obtain the Chinese medicine composition.

[0093] Test Example 1

[0094] Cheng * Ling, female, 45 years old, business owner, has many investments and social events. She wants to get pregnant again after her marriage changes. She had a comprehensive physical examination in January 2020, during which uterine B-ultrasound showed that several low-echo areas were visible in the myometrium of the uterine wall, with clear boundaries. The larger one was located on the anterior wall and was about 16*16cm in size. The Chinese medicine composition of the present invention was used for comprehensive maintenance for 9 months from July 2020 to April 2021, taking into account the maintenance of uterine fibroids. In April 2021, the uterine B-ultrasound was reviewed, showing that 2-3 low-echo nodules were visible on the posterior wall of the uterus, with clear boundaries and uneven internal echoes, none of which were close to the uterine cavity, and one of them was about 0.67*0.59cm in size. The echo of the remaining myometrium was thickened and uneven. Comparing the results of the two B-ultrasounds, it can be seen that the fibroids that were once located on the anterior wall of 16*16 are no longer there, and the location and size of the fibroids on the posterior wall have a relatively small impact on pregnancy. After consulting an obstetrician and gynecologist, the patient was very relieved to prepare for pregnancy.

[0095] Test Example 2

[0096] Ding*Rong, female, 45 years old, business owner, has a lot of company socializing, which requires hard work. A physical examination in December 2020 showed that the uterus had a regular shape, uneven myometrial echo, and low-echo nodules of about 3.0*2.3cm in size were visible in the myometrium, and she was diagnosed with uterine fibroids. Because the stomach and heart were maintained from March to September 2020, the degree of improvement and progress was very satisfactory. After checking the condition of uterine fibroids in December 2020, the Chinese medicine composition of the present invention was used for systematic maintenance for 3 months in January 2021, taking into account the improvement of uterine fibroids. After the individual felt that the physiological period was in good condition, the maintenance was suspended. No comparative data was made. It was not until the physical examination in December 2022 that the uterine B-ultrasound was rechecked, showing that the myometrium had uneven echoes, several low-echo nodules were seen inside, the boundaries were still clear, and the largest was 2.8*2.0cm. Although the prescription was discontinued for one and a half years, compared with the previous uterine B-ultrasound, the uterine fibroids were still reduced by 18.8%.

[0097] Test Example 3

[0098] Li * Li, female, 48 years old, business owner, engaged in the beauty industry. In April 2019, the B-ultrasound of the uterus showed uneven echo in the uterine area, and a low-echo light group of about 6*5mm in size could be seen on the anterior wall of the uterus, with clear boundaries and regular shapes. In 2019, 2020, and 2021, the Chinese medicine composition of the present invention was used for systematic maintenance for three months each year, taking into account the improvement of uterine fibroids. In May 2022, the B-ultrasound of the uterus was reviewed, showing that the size and shape of the uterine body were the same, the echo of the uterine wall was still uniform, the endometrial line was centered, and the thickness was about 3mm. Several small anechoic dark areas were explored in the cervical canal, which were protected from light, and the larger one was about 9*6mm. Compared with the B-ultrasound of the uterus in 2019, it can be seen that the uterine fibroids are no longer there, and there are cysts in the cervix. In 2022, the system was maintained as usual for 3 months, taking into account the maintenance of the uterus. The B-ultrasound of the uterus in the physical examination in 2023 showed: postmenopausal uterus, uneven echo of the myometrium, and a cervical cyst of about 3mm in size.

[0099] Test Example 4

[0100] Lin*, female, 52 years old, a staff member of the procuratorate, is in menopause. In July 2023, the uterine B-ultrasound showed that the size of the uterus was about 51*42*50mm, the shape was full, the capsule was smooth, and an inhomogeneous echo was visible on the posterior wall of the uterus, with a range of about 42*39*37, unclear boundaries, regular shape, and uneven internal echoes. CDFI: short branch-like blood flow signals were visible. The diagnosis was possible adenomyoma. The Chinese medicine composition of the present invention was used to start system maintenance and take into account uterine maintenance. In April 2024, the uterine B-ultrasound showed: the size of the uterus was 37*35*43, the shape was full, the capsule was smooth, the posterior wall solid echo was uneven, and an inhomogeneous echo was visible inside, with a range of about 16*15mm, unclear boundaries, regular shape, and uneven internal echoes. CDFI: short branch-like blood flow signals were visible. Compared with the last B-ultrasound data, the range of uneven echoes was reduced by 85%. Continue to maintain the uterus. In September 2024, the ultrasound examination of the uterus showed: the uterus was anterior, about 56*47*39 in size, normal in shape, smooth capsule, thickened and uneven echo of the posterior wall, and CDFI: dot-like blood flow signals were visible in the parenchyma. Compared with the previous two ultrasounds, the uneven range has been reduced to an inconspicuous level, and the blood flow signal in the parenchyma has changed.

[0101] Test Example 5

[0102] Luo * Ying, female, 44 years old, business owner, family abnormal genes are common, and there is potential pressure on the lungs and stomach. Personally, I don’t pay much attention to my health. The B-ultrasound of the uterus during the physical examination in April 2021 showed that there was no abnormality in the uterus, and multiple cystic dark areas of varying sizes were found in the cervix. The larger one was measured to be about 0.7 cm in diameter, with clear boundaries and acceptable sound inside. After one month of maintenance in April 2021, it was suspended until April 2022 when I felt that my body was very uncomfortable, and I started to maintain it seriously again. After a year, there was no physical examination before maintenance. The maintenance was mainly carried out for the symptoms of the lungs and stomach, while taking into account the maintenance of the uterus. After 3 months, in July 2022, the review was conducted, in which the B-ultrasound of the uterus showed multiple cystic nodules in the cervix, one of which was about 0.5*0.4 cm in size. Although there is no comparison with uterine fibroids, the changes in cervical cysts show that the Chinese medicine composition of the present invention is effective in maintaining uterine tissue.

[0103] Test Example 6

[0104] Ma*Hua, female, 40 years old, the owner of a breakfast shop, gets up early every day and is busy. She has three children and is under great pressure from work and life. In 2022, it was found that the uterine fibroids were relatively large. Regular check-ups showed that they were getting bigger and bigger. In April 2024, the uterine B-ultrasound showed: the uterus was tilted forward, the uterine body was about 75*71*110mm in size, full in shape, smooth in capsule, and a low-echo mass was seen on the right anterior wall of the uterus, about 76*66*70 in size, with clear boundaries, uneven internal echoes, and protruding outside the uterine contour. The uterine fibroids are relatively large. After three months of maintenance using the Chinese medicine composition of the present invention, the B-ultrasound of the uterus in July 2024 showed: the uterus was anterior, 63*59*67mm in size, with clear outlines, smooth surface, and medium echoes of the substance. A 75*51mm mass was visible in the right anterior wall muscle layer, with clear boundaries, varying echo strengths, and uneven distribution of light spots. Compared with B-ultrasound, the size of the uterus has shrunk by 57%. The uterine fibroids cannot be completely compared because of the deviation in the dimensions measured by the two hospitals, but based on the existing data, it has shrunk by at least 10%.

[0105] In summary, it can be seen that the synergistic use of the medicinal components such as yam, codonopsis and atractylodes as described in the present invention can effectively improve the symptoms of uterine tissue-related diseases such as uterine fibroids, adenomyoma, cervical cysts, etc., reduce the volume of fibroids or cysts, and improve the quality of life of patients; it can more comprehensively improve the body's functions and more systematically repair uterine tissue; it also has a certain improvement effect on symptoms.

[0106] The above is only a preferred embodiment of the present invention. It should be pointed out that for ordinary technicians in this technical field, several improvements and modifications can be made without departing from the principle of the present invention. These improvements and modifications should also be regarded as the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for treating uterine tissue-related diseases, characterized in that: The invention comprises the following components in parts by weight: 18-23 parts of yam, 12-17 parts of codonopsis pilosula, 12-17 parts of atractylodes macrocephala, 13-18 parts of dodder seeds, 13-17 parts of ligustrum lucidum fruits, 8-13 parts of lotus seeds, 7-12 parts of mistletoe, 7-13 parts of smilax glabra, 5-15 parts of coix seeds, 8-13 parts of selfheal, 8-12 parts of kelp, 7-12 parts of seaweed, 8-12 parts of cassia twig and 4-8 parts of fritillaria cirrhosa.

2. The Chinese medicine composition according to claim 1, characterized in that: The invention comprises the following components in parts by weight: 19-22 parts of yam, 13-16 parts of codonopsis pilosula, 13-16 parts of atractylodes macrocephala, 14-17 parts of dodder seeds, 14-16 parts of glossy privet fruits, 8.5-12 parts of lotus seeds, 8-11 parts of mistletoe, 8-12.5 parts of smilax glabra, 6-12 parts of coix seeds, 9-11 parts of selfheal, 9-11 parts of kelp, 8-11 parts of seaweed, 9-11 parts of cassia twig and 5-7 parts of fritillaria cirrhosa.

3. The method for preparing the Chinese medicine composition according to claim 1, characterized in that: The steps include: (1) After mixing the components described in claim 1, soaking and boiling them in water, filtering them to obtain a filter residue and a filtrate A; (2) mixing the filter residue with water, boiling again and filtering to obtain filtrate B; (3) Mix filtrate A and filtrate B to obtain.

4. The preparation method according to claim 3, characterized in that: The amount of water added in step (1) is 2-4 times the total mass of the components described in claim 1.

5. The preparation method according to claim 3, characterized in that: The soaking time in step (1) is 25-35 minutes.

6. The preparation method according to claim 3, characterized in that: The decoction in step (1) and the re-decoction in step (2) are both performed by boiling until the water boils and then switching to medium heat to continue decocting; The time for continuing to decoct is 15-25 minutes.

7. Use of the Chinese medicine composition according to claim 1 or 2, or the Chinese medicine composition prepared by the preparation method according to any one of claims 3 to 6, in the preparation of drugs for treating uterine tissue-related diseases.

8. The use according to claim 7, characterized in that: The uterine tissue related diseases include uterine fibroids, adenomyomas and cervical cysts.

9. The use according to claim 7, characterized in that: The dosage form of the medicine for treating uterine tissue-related diseases includes powder, granule, tablet or decoction.

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