Preparation process of industrialized medicinal cellulose diacetate
By optimizing the cellulose activation, esterification, neutralization and hydrolysis reaction steps, low viscosity medicinal cellulose diacetate esters were prepared, solving the problem of high viscosity of cellulose diacetate in the prior art, and achieving industrial preparation that meets the pharmacopoeia standards.
Patent Information
- Application Number
- CN202311245378.3
- Authority / Receiving Office
- CN · China
- Patent Type
- Applications(China)
- Current Assignee / Owner
- Filing Date
- 2023-09-26
- Publication Date
- 2025-03-28
AI Technical Summary
The prior art is difficult to achieve the industrial preparation of medicinal cellulose diacetate, and the prepared cellulose diacetate has a high viscosity and is not suitable for medicinal use.
A process for preparing medicinal cellulose diacetate esters is provided, including cellulose activation, esterification reaction, neutralization reaction, hydrolysis reaction and washing steps, and control the acetic acid binding amount and molecular weight distribution to reduce viscosity by optimizing process parameters such as temperature, time and catalyst use.
The low viscosity preparation of medicinal cellulose diacetate is achieved, with acetic acid binding amount ranging from 53% to 57%, a weight average molecular weight ranging from 95,000 to 105,000, and a molecular weight distribution of 1.8 to 2.1. The product quality meets the 2015 edition of the pharmacopoeia standards and is suitable for the pharmaceutical field.