Macroenergy heat capacity laser and anti-vascularization generation laser

Abstract

The invention provides a large-energy heat capacity laser and an anti-vascularization generation laser. The large-energy heat capacity laser comprises a pumping source, a light guide cone and a laser crystal group, wherein the laser crystal group comprises a plurality of laser crystal sheets, any laser crystal sheet is cut along a set wavelength non-critical phase matching direction, the thickness in a light transmission direction is 1-3mm, and the area is greater than 10mm * 10mm; the plurality of laser crystal sheets are arranged and distributed along the direction from left to right, the light-passing surfaces of all the laser crystal sheets are optically polished and coated, a gap is formed between any two adjacent laser crystal sheets, and heat-conducting fluid can flow through the gap; the laser crystal wafer is installed in the cooling container and soaked in the heat-conducting fluid, the heat-conducting fluid circularly flows through the cooling container to cool the laser crystal wafer, and the defects that the laser crystal wafer is small in heat conductivity coefficient and low in heat transfer efficiency are thoroughly overcome. The laser has important application prospects in the fields of biological detection, medical cosmetology, scar treatment and the like.

Description

Technical Field

[0001] The present invention relates to the field of laser technology, in particular to a large-energy heat capacity laser and a laser for anti-angiogenesis. Background Art

[0002] The target chromophores of blood vessels are oxyhemoglobin and deoxyhemoglobin, both of which have multiple absorption peaks (ref. Figure 1 As shown in the figure, the absorption peaks of oxygenated hemoglobin are 418nm, 542nm and 577nm, and the absorption peaks of deoxyhemoglobin are 535nm and 570nm). At the same time, the wavelength also affects the penetration depth of the laser. Below 1200nm, the longer the wavelength, the deeper the penetration. Therefore, the wavelength of the laser used to treat vascular diseases should be slightly longer, so that the selective absorption and penetration of the target tissue can be taken into account. In addition, the laser needs to penetrate the melanin barrier of the epidermis to reach the target blood vessels. When treating skin vascular diseases, blood vessels absorb light and are coagulated; when treating scars, it is based on the same technical idea. The healing process of skin wounds is accompanied by excessive angiogenesis, which is closely related to the formation of pathological scars. Scar tissue usually contains more microvessels than the dermis of normal skin. When using lasers to treat scars, the microvessels inside the scar tissue can be closed, so that the pathological scars cannot obtain nutrients through the microvessels and gradually necrotize. A large number of studies have also confirmed the effectiveness of anti-vascular chemotherapy in inhibiting pathological scars.

[0003] At present, 595nm dye lasers are widely used in the treatment of vascular diseases, but dye lasers have limitations such as toxic dyes, short working hours, irregular maintenance, and high costs. Many medical and scientific research institutions use high-energy 532nm solid lasers instead of 595nm dye lasers. Although the absorption coefficient of blood at 532nm is also high, and the frequency-doubled Nd:YAG laser is also effective in treating superficial vascular diseases, it has poor penetration in the skin and is more easily absorbed by the melanin in the epidermis, so its application range is limited.

[0004] The inventors noticed that 545nm laser is closer to the absorption peak of 542nm than 532nm laser, and has higher absorption efficiency. In addition, 1090nm laser has stronger penetration. Therefore, if 545nm laser can be used to treat vascular diseases, the curative effect will be better than that of traditional 532nm laser. However, existing 545nm semiconductor lasers generally have the defects of low emission power and high cost. Existing 545nm semiconductor lasers cannot be directly used for skin vascular diseases.

[0005] The chemical formula of rare earth-doped calcium oxyborate crystal is , where Re represents Y (yttrium) and lanthanide rare earth elements Gd and La. This type of crystal belongs to the space group Cm and point group m. It is a bicyclic crystal with low symmetry. It has stable chemical properties, is not easy to deliquesce, has second-order nonlinear optical properties and a moderate nonlinear optical coefficient (d11=1.5 pm / V), a high damage threshold (>1 GW / cm2), and is easy to grow large-sized high-optical quality crystals. At the same time, it has a large specific heat capacity coefficient of 700J / kg.K, which is suitable for heat capacity lasers. Heat capacity lasers are divided into two stages: working and heat dissipation. When working, the crystal relies on its own heat capacity to absorb heat, and the crystal and LD array continue to rise in temperature. The crystal continues to dissipate heat outside the working time, and when the crystal drops to a certain temperature, it can start the next work. However, when lasers using rare earth calcium borate oxychloride crystals operate at high power, there are serious thermal lens effects and thermally induced birefringence effects, which can cause a significant drop in the laser output power or even catastrophic damage to the crystal. Therefore, existing lasers using rare earth calcium borate oxychloride crystals are difficult to use to directly generate high-power lasers, and are therefore difficult to use directly for the treatment of skin vascular diseases and anti-vascularization of scars.

[0006] Therefore, how to develop a 545nm semiconductor laser with high emission power and low cost, and enable it to be used to treat skin vascular diseases and anti-vascularization of scars, is a technical problem that needs to be solved urgently in the existing technology. Summary of the invention

[0007] Therefore, the technical problem to be solved by the present invention is to overcome the technical defects of the prior art that a high-energy 532nm solid laser is used instead of a 595nm fuel laser, but the laser has poor penetration into the skin and is more easily absorbed by epidermal melanin, thus having limited effect in treating vascular diseases, thereby providing a 545nm semiconductor laser with high emission power and low cost.

[0008] The invention also provides a laser for resisting angiogenesis.

[0009] To this end, the present invention provides a large energy heat capacity laser, comprising: a pump source, at least one, for emitting pump light; A light guide cone, arranged in one-to-one correspondence with the pump source, and used for focusing the pump light; A laser crystal group, used for absorbing the pump light focused by the light guide cone and outputting laser light of a set wavelength; The laser crystal group includes a plurality of laser crystal sheets, and any of the laser crystal sheets is cut along the non-critical phase matching direction of the set wavelength, has a thickness of 1-3 mm in the light transmission direction, and has an area greater than 10 mm×10 mm; Several laser crystal sheets are arranged in parallel from left to right, and the light-transmitting surfaces of all the laser crystal sheets are optically polished and coated, wherein: The left side of the leftmost laser crystal sheet is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly reflective to the output light, and the right side is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly reflective to the output light; The left side of the rightmost laser crystal sheet is coated with a dielectric film that is highly transparent to the pump light, highly transparent to the fundamental frequency light, and highly transparent to the output light, and the right side is coated with a dielectric film that is highly transparent to the pump light, highly reflective or partially transparent to the fundamental frequency light, and highly transparent to the output light; Both sides of the middle laser crystal plate are coated with dielectric films with high transmittance to the pump light, high transmittance to the fundamental frequency light, and high transmittance to the output light; There is a gap between any two adjacent laser crystal sheets, and the gap allows a heat transfer fluid to flow through; The laser crystal piece is installed in a cooling container and is immersed in the heat transfer fluid. The heat transfer fluid circulates through the cooling container to cool the laser crystal piece.

[0010] The present invention also provides another large energy heat capacity laser, comprising: a pump source, at least one, for emitting pump light; A light guide cone, arranged in one-to-one correspondence with the pump source, and used for focusing the pump light; A laser crystal group, used for absorbing the pump light focused by the light guide cone and outputting laser light of a set wavelength; The laser crystal group includes a plurality of laser crystal sheets, and any of the laser crystal sheets is cut along the non-critical phase matching direction of the set wavelength, has a thickness of 1-3 mm in the light transmission direction, and has an area greater than 10 mm×10 mm; Several laser crystal sheets are arranged from left to right, and any two laser crystal sheets are tilted at a certain angle, and all the light-transmitting surfaces of the laser crystal sheets are optically polished and coated, wherein: The left side of the leftmost laser crystal sheet is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly reflective to the output light, and the right side is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the output light; The left side of the rightmost laser crystal sheet is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the output light, and the right side is coated with a dielectric film that is highly transparent to the pump light, highly reflective or partially transmits the fundamental frequency light, and highly transparent to the output light; The left side of the middle laser crystal plate is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the output light; the right side is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the output light; There is a gap between any two adjacent laser crystal sheets, and the gap allows a heat transfer fluid to flow through; The laser crystal piece is installed in a cooling container and is immersed in the heat transfer fluid. The heat transfer fluid circulates through the cooling container to cool the laser crystal piece.

[0011] As a preferred solution, the angle between any two adjacent laser crystal sheets is 0-10'.

[0012] As a preferred solution, the partial transmission refers to a transmittance of 1-10%.

[0013] As a preferred solution, the fundamental frequency light is a laser with a wavelength of 1090 nm, and the output light is a laser with a wavelength of 545 nm.

[0014] As a preferred solution, the laser crystal sheet is a rare earth ion-doped calcium oxygen borate crystal having laser effect and nonlinear optical effect, and the molecular formula is or The laser crystal sheet is cut along the 545nm yellow-green non-critical phase matching direction, and the cutting angle is θ=148.1°, φ=0°.

[0015] As a preferred solution, the number of pump sources is at least three, which enter the laser crystal sheet through the focusing and homogenization of the light guide cone respectively, and the output light is obtained after laser frequency conversion and nonlinear frequency conversion.

[0016] As a preferred solution, the pump source is formed by a stacked array of at least 10 50W bars; the pump source is powered by a TTL circuit, and the power pulse width is 0.5ms-100ms. Preferably, the power pulse width is 20-40ms.

[0017] As a preferred solution, the heat transfer fluid is pure water.

[0018] The present invention also provides an anti-angiogenesis laser for use in the treatment of skin vascular diseases and scar anti-angiogenesis, comprising the high-energy heat capacity laser as described in any one of the above items.

[0019] It should be noted that the terms "high reflection" and "high transmittance" in the present invention have well-known meanings in the art. "High reflection" means that the reflectivity of incident light of a specific wavelength or wavelength band is greater than 90%. "High transmittance" means that the transmittance of incident light of a specific wavelength or wavelength band is greater than 80%.

[0020] The technical solution provided by the present invention has the following advantages: 1. The high energy heat capacity laser of the present invention comprises a pump source, a light guide cone and a laser crystal group, wherein the pump source is at least one and is used to emit pump light; the light guide cone is arranged one-to-one with the pump source and is used to focus the pump light; the laser crystal group is used to absorb the pump light focused by the light guide cone and output laser light of a set wavelength; the high energy heat capacity laser of the present invention comprises a plurality of laser crystal sheets arranged in parallel from left to right to form a laser crystal group, and any laser crystal sheet is cut along the non-critical phase matching direction of the set wavelength, the thickness in the light passing direction is controlled to be 1-3 mm, and the crystal area is greater than 10 mm×10 mm; by coating a dielectric film on different laser crystal sheets constituting the laser crystal group, the laser crystal sheet absorbs the fundamental frequency light generated by the pump light, passes through all the laser crystal sheets, and oscillates and doubles the frequency between the leftmost and rightmost laser crystal sheets, thereby generating the output light after frequency doubling; The high-energy heat capacity laser of the present invention does not use a single laser crystal block, but uses a combination of several laser crystal sheets to form a laser crystal group. A gap is set between two adjacent laser crystal sheets to allow a heat-conducting fluid to pass through, and each laser crystal sheet is reasonably coated. The laser crystal group is immersed in a flowing heat-conducting fluid to work, thereby achieving high-energy laser output and completely solving the defects of low thermal conductivity and low heat transfer efficiency of laser crystals, and solving the problem of low output power and even damage to laser crystals caused by poor heat transfer of laser crystals in traditional lasers. The high-energy heat capacity laser of the present invention has high emission power and low cost, can be used to treat skin vascular diseases, and has important application prospects in the fields of biological detection, medical cosmetology, scar treatment, etc.

[0021] 2. The high-energy heat capacity laser of the present invention can also be designed to arrange several laser crystal sheets in a left-to-right direction, but there is a certain angle of inclination between any two laser crystal sheets. At this time, the coating strategy of the laser crystal sheets is also changed accordingly to oscillate and double the fundamental frequency light in each individual laser crystal sheet; after each laser crystal sheet absorbs the pump light and generates the fundamental frequency light through the laser crystal group set as above, it does not need to pass through all the laser crystal sheets, but only needs to oscillate and double the frequency inside each individual laser crystal sheet, and the output light after frequency doubling is transmitted to the right for output; the high-energy heat capacity laser of the present invention combines the output light outputted individually by several laser crystal sheets together, thereby realizing high-energy output light laser output.

[0022] 3. The high-energy heat capacity laser of the present invention has a dielectric film on the right side of the rightmost laser crystal sheet that is highly transparent to pump light, partially transparent to fundamental frequency light, and highly transparent to outgoing light, so that a laser containing both fundamental frequency light and outgoing light can be output from the right side; taking the fundamental frequency light as 1090nm laser and the outgoing light as 545nm laser as an example, when the right side of the last laser crystal sheet is coated with a dielectric film that is partially transparent to fundamental frequency light 1090nm laser and highly transparent to outgoing light 545nm laser, the laser emitted from the right side of the laser crystal sheet contains both 545nm and 1090nm wavelengths. Since 545nm laser is more suitable for the treatment of superficial skin blood vessels, and 1090nm laser is more suitable for the treatment of deep skin blood vessels, the combination of the two can treat skin with both superficial skin blood vessels and deep skin blood vessels, and the treatment efficiency is higher. The emergence of the high-energy 545nm and / or 1090nm yellow-green laser of the present invention fills the shortcoming of the serious thermal effect of yellow light self-frequency doubling laser, and has important application prospects in military industry, medical cosmetology and other fields.

[0023] 4. The present invention also provides an anti-angiogenesis laser for the treatment of skin vascular diseases and scar anti-angiogenesis, etc., comprising any of the large-energy heat capacity lasers described above; since it comprises the large-energy heat capacity laser described above, it can output a higher-power laser and is not easily damaged by the laser crystal, and has good market application prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0024] In order to more clearly illustrate the technical solutions in the prior art or the specific implementation manner of the present invention, the drawings used in the description of the prior art or the specific implementation manner are briefly introduced below.

[0025] Figure 1 It is the absorption curve of oxygenated hemoglobin and melanin to lasers of different wavelengths.

[0026] Figure 2 It is a structural principle diagram of the large energy heat capacity laser in Example 1 of the present invention.

[0027] Figure 3 It is a structural principle diagram of the large energy heat capacity laser in Example 2 of the present invention.

[0028] Figure numerals: 1, pump source; 2, light guide cone; 3, laser crystal group; 31, laser crystal plate. DETAILED DESCRIPTION

[0029] In order to make those skilled in the art better understand the present solution, the technical solution in the embodiments of the present application will be clearly and completely described below in conjunction with the drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, not all of the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work should fall within the scope of protection of the present application.

[0030] It should be noted that the terms "first", "second", etc. in this application are used to distinguish similar objects, and are not used to describe a specific order or sequence. In addition, the terms "including" and "having" and any variations thereof are intended to cover non-exclusive inclusions, for example, a process, method, system, product or device that includes a series of steps or units is not limited to those steps or units clearly listed, but may also include other steps or units that are not clearly listed or inherent to these processes, methods, products or devices.

[0031] In the present application, the terms "upper", "lower", "left", "right", "front", "back", "top", "bottom", "inside", "outside", "middle", "vertical", "horizontal", "lateral", "longitudinal" and the like indicate positions or positional relationships based on the positions or positional relationships shown in the accompanying drawings. These terms are mainly intended to better describe the present application and its embodiments, and are not intended to limit the indicated devices, elements or components to have a specific orientation, or to be constructed and operated in a specific orientation. In addition, in addition to being used to indicate orientation or positional relationships, some of the above terms may also be used to indicate other meanings. For example, the term "upper" may also be used to indicate a certain dependency or connection relationship in some cases. For those skilled in the art, the specific meanings of these terms in the present application can be understood according to the specific circumstances. In addition, the term "multiple" should mean two or more. It should be noted that the embodiments in the present application and the features in the embodiments may be combined with each other without conflict.

[0032] The present application will be described in detail below with reference to the accompanying drawings and in combination with embodiments.

[0033] Example 1

[0034] This embodiment provides a large energy heat capacity laser, such as Figure 1 As shown, it includes: a pump source 1, a light guide cone 2 and a laser crystal group 3; wherein: there are three pump sources 1 for emitting pump light; the light guide cones 2 are arranged one by one corresponding to the pump sources 1, and are also three, for focusing the pump light; the laser crystal group 3 is used to absorb the pump light after being focused by the light guide cone 2, and output laser of a set wavelength.

[0035] The laser crystal group 3 includes a plurality of laser crystal sheets 31, and any laser crystal sheet 31 is cut along the non-critical phase matching direction of the set wavelength, has a thickness of 1-3 mm in the light transmission direction, and has an area greater than 10 mm×10 mm.

[0036] In this embodiment, a plurality of laser crystal sheets 31 are arranged and distributed from left to right, and all of the laser crystal sheets 31 are arranged parallel to each other, and the light-transmitting surfaces of all of the laser crystal sheets 31 are optically polished and coated; wherein: the left side surface of the leftmost laser crystal sheet 31 is coated with a dielectric film with high transmittance to the pump light, high reflection to the fundamental frequency light, and high reflection to the output light, and the right side surface is coated with a dielectric film with high transmittance to the pump light, high transmittance to the fundamental frequency light, and high transmittance to the output light; the left side surface of the rightmost laser crystal sheet 31 is coated with a dielectric film with high transmittance to the pump light, high transmittance to the fundamental frequency light, and high transmittance to the output light, and the right side surface is coated with a dielectric film with high transmittance to the pump light, high reflection or partial transmission to the fundamental frequency light, and high transmittance to the output light; both side surfaces of the middle laser crystal sheet 31 are coated with dielectric films with high transmittance to the pump light, high transmittance to the fundamental frequency light, and high transmittance to the output light.

[0037] There is a gap between any two adjacent laser crystal plates 31, and the gap allows a heat transfer fluid to flow through; the laser crystal plates 31 are installed in a cooling container and are immersed in the heat transfer fluid, and the heat transfer fluid circulates through the cooling container to cool the laser crystal plates 31.

[0038] In this embodiment, the laser crystal plate 31 is a rare earth ion-doped calcium oxygen borate crystal having laser effect and nonlinear optical effect, and the molecular formula is or The laser crystal sheet is cut along the 545nm yellow-green non-critical phase matching direction, and the cutting angle is θ=148.1°, φ=0°. The fundamental frequency light is a 1090nm wavelength laser, and the output light is a 545nm wavelength laser.

[0039] In this embodiment, any two of the laser crystal sheets 31 are arranged in parallel; the pump light emitted by the pump source 1 is projected to the laser crystal sheet 31 after being focused and homogenized by the light guide cone 2. Since there are several laser crystal sheets 31 arranged side by side, and all of them are coated with a dielectric film with high transmittance to the pump light, the pump light projected to the laser crystal sheet 31 will pass through multiple laser crystal sheets 31. Each time it passes through a laser crystal sheet 31, the laser crystal sheet 31 can absorb the pump light and generate fundamental frequency light. The fundamental frequency light is oscillated and doubled in frequency between the leftmost laser crystal sheet 31 and the rightmost laser crystal sheet 31, forming an output light that is emitted from the right. Since multiple laser crystal sheets 31 are provided, the pump light can be absorbed layer by layer, and all of them can generate fundamental frequency light and generate output light after oscillation and frequency doubling, thereby improving the generation efficiency of the output light and producing an output laser with greater energy.

[0040] There is a gap between any two adjacent laser crystal sheets 31, and the gap is 0.1mm-1mm, which can allow the heat transfer fluid to flow at a speed of 0.5m / s, so as to quickly cool the laser crystal sheet 31 immersed in the heat transfer fluid, and reduce the high heat generation caused by the thermal lens effect and the thermally induced birefringence effect of the rare earth-doped calcium borate salt crystal when working at high power. In this embodiment, the heat transfer fluid is pure water.

[0041] When the right side of the rightmost laser crystal sheet 31 is coated with a dielectric film that is highly transparent to pump light, partially transparent to fundamental frequency light, and highly transparent to outgoing light, the laser output from the right side is a laser that contains both fundamental frequency light and outgoing light. Taking the fundamental frequency light of 1090nm laser and the outgoing light of 545nm laser as an example, when the right side of the last laser crystal sheet is coated with a dielectric film that is partially transparent to fundamental frequency light 1090nm laser and highly transparent to outgoing light 545nm laser, the laser emitted from the right side of the laser crystal sheet contains both 545nm and 1090nm wavelengths. Since 545nm laser is more suitable for the treatment of superficial skin blood vessels, and 1090nm laser is more suitable for the treatment of deep skin blood vessels, the combination of the two can treat skin with both superficial skin blood vessels and deep skin blood vessels, and the treatment efficiency is higher. The emergence of the high-energy 545nm and / or 1090nm yellow-green laser in this embodiment fills the shortcoming of the serious thermal effect of yellow self-frequency doubling laser, and has important application prospects in military industry, medical beauty and other fields.

[0042] The pump source 1 in this embodiment is formed by a stacked array of at least 10 50W bars. The pump source 1 is powered by a TTL circuit, and the power pulse width is 0.5ms-100ms; preferably, the power pulse width is 20-40ms.

[0043] Example 2

[0044] This embodiment provides a large energy heat capacity laser, which is a variation of the embodiment 1, except that any two laser crystal sheets 31 are tilted at a certain angle (refer to Figure 3 As shown in FIG. 1 ), at this time, the coating strategy of the laser crystal piece is also changed accordingly so that the fundamental frequency light oscillates and doubles the frequency in each individual laser crystal piece 31 .

[0045] Specifically, the angle between any two adjacent laser crystal plates 31 is 0-10'.

[0046] The coating strategy is adjusted as follows: the left side surface of the leftmost laser crystal piece 31 is coated with a dielectric film with high transmittance to the pump light, high reflection to the fundamental frequency light, and high reflection to the output light, and the right side surface is coated with a dielectric film with high transmittance to the pump light, high reflection to the fundamental frequency light, and high transmittance to the output light; the left side surface of the rightmost laser crystal piece 31 is coated with a dielectric film with high transmittance to the pump light, high reflection to the fundamental frequency light, and high transmittance to the output light, and the right side surface is coated with a dielectric film with high transmittance to the pump light, high reflection or partial transmission to the fundamental frequency light, and high transmittance to the output light; the left side surface of the middle laser crystal piece 31 is coated with a dielectric film with high transmittance to the pump light, high reflection to the fundamental frequency light, and high transmittance to the output light; the right side surface is coated with a dielectric film with high transmittance to the pump light, high reflection to the fundamental frequency light, and high transmittance to the output light.

[0047] After the laser crystal group 3 is set up as above, after each laser crystal piece 31 absorbs the pump light and generates the fundamental frequency light, it does not need to pass through all the laser crystal pieces 31, but only needs to oscillate and double the frequency inside each individual laser crystal piece 31, and the output light after frequency doubling is transmitted to the right for output; the large energy heat capacity laser of this embodiment combines the output light outputted individually by several laser crystal pieces 31 together, thereby realizing the output light laser output of large energy.

[0048] Example 3

[0049] This embodiment provides an anti-angiogenesis laser for the treatment of skin vascular diseases and scar anti-angiogenesis. The laser uses the high-energy heat capacity laser described in Embodiment 1 or 2.

[0050] Anti-angiogenesis refers to a therapeutic strategy that intervenes in disease or abnormal tissue growth by inhibiting the formation of new blood vessels. There is usually such a relationship between angiogenesis and scar formation: in the early stages of wound healing, new blood vessels provide oxygen and nutrients for tissue repair, while in pathological scars (such as hypertrophic scars and keloids), the formation of new blood vessels may be overactive. These new blood vessels not only provide additional nutrients for scars, but also release pro-inflammatory factors and growth factors (such as VEGF, TGF-β), stimulating fibroblast proliferation and excessive collagen deposition, resulting in scar thickening and hardening.

[0051] The laser of this embodiment can inhibit angiogenesis, reduce blood supply to scars, block the nutritional source of scar tissue, and restrict its growth; it can regulate inflammation and fibrosis, inhibit pro-angiogenic factors (such as VEGF), reduce inflammatory mediators and collagen synthesis, and promote scar softening; it can also promote scar maturation and transform overproliferative scars into normal tissues.

[0052] Since the large energy heat capacity laser in the above embodiment is adopted, all the advantages brought by adopting the above laser are possessed.

[0053] Obviously, the above embodiments are merely examples for clear explanation, and are not intended to limit the implementation methods. For ordinary technicians in the relevant field, other different forms of changes or modifications can be made based on the above description. It is not necessary and impossible to list all the implementation methods here. The obvious changes or modifications derived from them are still within the protection scope of this innovative technical solution.

Claims

1. A high energy heat capacity laser, comprising: A pump source (1), at least one, for emitting pump light; A light guide cone (2), arranged in one-to-one correspondence with the pump source (1), and used for focusing the pump light; A laser crystal group (3) is used to absorb the pump light focused by the light guide cone (2) and output laser light of a set wavelength; Features: The laser crystal group (3) comprises a plurality of laser crystal sheets (31), and any one of the laser crystal sheets (31) is cut along a non-critical phase matching direction of a set wavelength, has a thickness of 1-3 mm in the light transmission direction, and has an area greater than 10 mm×10 mm; A plurality of laser crystal sheets (31) are arranged in parallel from left to right, and the light-transmitting surfaces of all the laser crystal sheets (31) are optically polished and coated, wherein: The left side of the leftmost laser crystal sheet (31) is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly reflective to the output light, and the right side is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly reflective to the output light; The left side of the rightmost laser crystal sheet (31) is coated with a dielectric film that is highly transparent to the pump light, highly transparent to the fundamental frequency light, and highly transparent to the output light, and the right side is coated with a dielectric film that is highly transparent to the pump light, highly reflective or partially transparent to the fundamental frequency light, and highly transparent to the output light; Both sides of the middle laser crystal plate (31) are coated with dielectric films that are highly transparent to the pump light, highly transparent to the fundamental frequency light, and highly transparent to the output light; There is a gap between any two adjacent laser crystal sheets (31), and the gap allows a heat-conducting fluid to flow through; The laser crystal plate (31) is installed in a cooling container and is immersed in the heat-conducting fluid, and the heat-conducting fluid circulates through the cooling container to cool the laser crystal plate (31).

2. A high energy heat capacity laser, comprising: A pump source (1), at least one, for emitting pump light; A light guide cone (2), arranged in one-to-one correspondence with the pump source (1), and used for focusing the pump light; A laser crystal group (3) is used to absorb the pump light focused by the light guide cone (2) and output laser light of a set wavelength; Features: The laser crystal group (3) comprises a plurality of laser crystal sheets (31), and any one of the laser crystal sheets (31) is cut along a non-critical phase matching direction of a set wavelength, has a thickness of 1-3 mm in the light transmission direction, and has an area greater than 10 mm×10 mm; A plurality of laser crystal sheets (31) are arranged and distributed in a direction from left to right, and any two of the laser crystal sheets (31) are arranged to be inclined at a certain angle, and the light-transmitting surfaces of all the laser crystal sheets (31) are optically polished and coated, wherein: The left side of the leftmost laser crystal sheet (31) is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly reflective to the output light, and the right side is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the output light; The left side of the rightmost laser crystal sheet (31) is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the output light, and the right side is coated with a dielectric film that is highly transparent to the pump light, highly reflective or partially transmits the fundamental frequency light, and highly transparent to the output light; The left side of the middle laser crystal plate (31) is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the output light; the right side is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the output light; There is a gap between any two adjacent laser crystal sheets (31), and the gap allows a heat-conducting fluid to flow through; The laser crystal plate (31) is installed in a cooling container and is immersed in the heat-conducting fluid, and the heat-conducting fluid circulates through the cooling container to cool the laser crystal plate (31).

3. The high energy heat capacity laser according to claim 2, characterized in that: The included angle between any two adjacent laser crystal sheets (31) is 0-10'.

4. The high energy heat capacity laser according to any one of claims 1 to 3, characterized in that: The partial transmission refers to a transmittance of 1-10%.

5. The high energy heat capacity laser according to any one of claims 1 to 3, characterized in that: The fundamental frequency light is a laser with a wavelength of 1090 nm, and the output light is a laser with a wavelength of 545 nm.

6. The high energy heat capacity laser according to any one of claims 1 to 3, characterized in that: The laser crystal plate (31) is a rare earth ion-doped calcium oxygen borate crystal having laser effect and nonlinear optical effect, and has a molecular formula of or The laser crystal sheet is cut along the 545nm yellow-green non-critical phase matching direction, and the cutting angle is θ=148.1°, φ=0°.

7. The high energy heat capacity laser according to any one of claims 1 to 3, characterized in that: The pump sources (1) are at least three, and enter the laser crystal plate (31) through the focusing and homogenization of the light guide cone (2) respectively, and after laser frequency conversion and nonlinear frequency conversion are performed, the output light is obtained.

8. The high energy heat capacity laser according to any one of claims 1 to 3, characterized in that: The pump source (1) is formed by a stacked array of at least 10 50W bars; the pump source is powered by a TTL circuit, and the power pulse width is 0.5ms-100ms. Preferably, the power pulse width is 20-40ms.

9. The high energy heat capacity laser according to any one of claims 1 to 3, characterized in that: The heat transfer fluid is pure water.

10. An anti-angiogenesis laser for the treatment of skin vascular diseases and scar anti-angiogenesis, characterized in that: The invention comprises a large energy heat capacity laser as claimed in any one of claims 1 to 9.

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