A high-energy heat capacity laser and a laser for anti-angiogenesis

Abstract

The application provides a high-energy heat capacity laser and an anti-angiogenesis laser, comprising a pump source, a light guide cone and a laser crystal group; wherein the laser crystal group comprises a plurality of laser crystal pieces, and any one of the laser crystal pieces is cut along a non-critical phase matching direction of a set wavelength, the thickness of the light transmission direction is 1-3 mm, and the area is greater than 10 mm*10 mm; the plurality of laser crystal pieces are arranged and distributed along a left-to-right direction, the light transmission surfaces of all the laser crystal pieces are optically polished and coated, there is a gap between any two adjacent laser crystal pieces, and the gap allows a heat-conducting fluid to flow through; the laser crystal pieces are installed in a cooling container and are immersed in the heat-conducting fluid, and the heat-conducting fluid circulates through the cooling container to cool the laser crystal pieces, thereby completely solving the defects of small thermal conductivity and low heat transfer efficiency of the laser crystal pieces. The laser has important application prospects in the fields of biological detection, medical cosmetology, scar treatment and the like.

Description

Technical Field

[0001] This invention relates to the field of laser technology, specifically to a high-energy thermal capacity laser and a laser for preventing angiogenesis. Background Technology

[0002] The target chromophores in blood vessels are oxyhemoglobin and deoxyhemoglobin, both of which have multiple absorption peaks (see reference). Figure 1 As shown, the absorption peaks of oxyhemoglobin are 418nm, 542nm, and 577nm, while those of deoxyhemoglobin are 535nm and 570nm. Wavelength also affects the penetration depth of the laser; below 1200nm, the longer the wavelength, the deeper the penetration. Therefore, the laser wavelength for treating vascular diseases needs to be slightly longer to balance selective absorption and penetration by the target tissue. Furthermore, the laser needs to penetrate the melanin barrier of the epidermis to reach the target blood vessels. In treating vascular diseases of the skin, blood vessels absorb light and are coagulated; the same technical approach is used in treating scars. Skin wounds heal with excessive angiogenesis, which is closely related to the formation of pathological scars. Scar tissue typically contains more microvessels than the dermis of normal skin. When using lasers to treat scars, the microvessels inside the scar tissue can be sealed, preventing the pathological scar from obtaining nutrients through the microvessels and causing it to gradually die. Numerous studies have also confirmed the effectiveness of anti-angiogenic chemotherapy in inhibiting pathological scars.

[0003] Currently, 595nm dye lasers are widely used in the treatment of vascular diseases. However, dye lasers have limitations such as toxic dyes, short operating time, the need for regular maintenance, and high costs. Many medical and research institutions use high-energy 532nm solid-state lasers instead of 595nm dye lasers. Although blood also has a high absorption coefficient at 532nm, and frequency-doubled Nd:YAG lasers are effective in treating superficial vascular diseases, their penetration into the skin is poor, and they are more easily absorbed by melanin in the epidermis, thus limiting their application.

[0004] The inventors noted that 545nm lasers are closer to the absorption peak of 542nm than 532nm lasers, resulting in higher absorption efficiency. Furthermore, 1090nm lasers have stronger penetrating power. Therefore, if 545nm lasers could be used to treat vascular diseases, the therapeutic effect would be better than that of traditional 532nm lasers. However, existing 545nm semiconductor lasers generally suffer from low emission power and high cost, and cannot be directly used for skin vascular diseases.

[0005] The chemical formula of rare earth-doped calcium oxyborate crystals is: In this model, Re represents Y (yttrium) and the lanthanide rare earth elements Gd and La. This type of crystal belongs to space group Cm and point group m. It is a bicyclic crystal with low symmetry, possessing advantages such as chemical stability, low deliquescence, second-order nonlinear optical properties, a moderate nonlinear optical coefficient (d11 = 1.5 pm / V), high damage threshold (>1 GW / cm2), and ease of growing large-size, high-optical-quality crystals. It also has a large specific heat capacity coefficient of 700 J / kg·K, making it suitable for thermal capacity lasers. Thermal capacity lasers consist of two phases: operation and heat dissipation. During operation, the crystal absorbs heat through its own thermal capacity, causing a continuous temperature rise in both the crystal and the LD array. Outside of operation, the crystal continuously dissipates heat, and when the crystal cools to a certain temperature, the next operation can begin. However, lasers using rare-earth-doped calcium borate crystals exhibit severe thermal lensing and thermally induced birefringence effects when operating at high power, which can lead to a significant drop in laser output power or even catastrophic damage to the crystal. Therefore, existing lasers using rare-earth-doped calcium borate crystals are difficult to use to directly generate high-power lasers, and thus difficult to use directly for the treatment of skin vascular diseases and anti-angiogenic scarring.

[0006] Therefore, how to develop a 545nm semiconductor laser with high emission power and low cost, and make it usable for treating vascular skin diseases and anti-angiogenic treatment of scars, is a technical problem that urgently needs to be solved in the current technology. Summary of the Invention

[0007] Therefore, the technical problem to be solved by the present invention is to overcome the technical defects of the prior art, which uses a high-energy 532nm solid-state laser to replace a 595nm fuel laser, but has poor skin penetration and is more easily absorbed by epidermal melanin, thus having limited effect on the treatment of vascular diseases. The present invention provides a 545nm semiconductor laser with high emission power and low cost.

[0008] The present invention also provides a laser for inhibiting angiogenesis.

[0009] Therefore, the present invention provides a high-energy thermal capacity laser, comprising:

[0010] A pump source, at least one, is used to emit pump light;

[0011] A light guide cone, corresponding to each of the pump sources, is used to focus the pump light;

[0012] A laser crystal assembly is used to absorb the pump light focused by the light guide cone and output laser light of a set wavelength.

[0013] The laser crystal assembly includes several laser crystal slices, and each laser crystal slice is cut along a non-critical phase matching direction of a set wavelength, with a thickness of 1-3 mm in the light transmission direction and an area greater than 10 mm × 10 mm.

[0014] Several laser crystal wafers are arranged in parallel from left to right, and the light-transmitting surfaces of all the laser crystal wafers are optically polished and coated, wherein:

[0015] The leftmost laser crystal chip has a dielectric film deposited on its left side that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly reflective to the emitted light, and a dielectric film deposited on its right side that is highly transparent to the pump light, highly transparent to the fundamental frequency light, and highly transparent to the emitted light.

[0016] The rightmost laser crystal chip has a dielectric film deposited on its left side that is highly transparent to the pump light, highly transparent to the fundamental frequency light, and highly transparent to the emitted light, and a dielectric film deposited on its right side that is highly transparent to the pump light, highly reflective or partially transmissive to the fundamental frequency light, and highly transparent to the emitted light.

[0017] Both sides of the middle laser crystal are coated with a dielectric film that is highly transparent to the pump light, highly transparent to the fundamental frequency light, and highly transparent to the emitted light;

[0018] There is a gap between any two adjacent laser crystal wafers, which allows heat-conducting fluid to flow through;

[0019] The laser crystal is installed in a cooling container and immersed in the heat-conducting fluid, which circulates through the cooling container to cool the laser crystal.

[0020] This invention also provides another high-energy thermal capacity laser, comprising:

[0021] A pump source, at least one, is used to emit pump light;

[0022] A light guide cone, corresponding to each of the pump sources, is used to focus the pump light;

[0023] A laser crystal assembly is used to absorb the pump light focused by the light guide cone and output laser light of a set wavelength.

[0024] The laser crystal assembly includes several laser crystal slices, and each laser crystal slice is cut along a non-critical phase matching direction of a set wavelength, with a thickness of 1-3 mm in the light transmission direction and an area greater than 10 mm × 10 mm.

[0025] A plurality of laser crystal wafers are arranged from left to right, and any two laser crystal wafers are tilted at a certain angle. The light-transmitting surfaces of all the laser crystal wafers are optically polished and coated, wherein:

[0026] The leftmost laser crystal chip has a dielectric film deposited on its left side that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly reflective to the emitted light, and a dielectric film deposited on its right side that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the emitted light.

[0027] The rightmost laser crystal chip has a dielectric film deposited on its left side that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the emitted light, and a dielectric film deposited on its right side that is highly transparent to the pump light, highly reflective to the fundamental frequency light or partially transparent, and highly transparent to the emitted light.

[0028] The left side of the middle laser crystal is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the emitted light; the right side is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the emitted light.

[0029] There is a gap between any two adjacent laser crystal wafers, which allows heat-conducting fluid to flow through;

[0030] The laser crystal is installed in a cooling container and immersed in the heat-conducting fluid, which circulates through the cooling container to cool the laser crystal.

[0031] As a preferred embodiment, the included angle between any two adjacent laser crystal slices is 0-10'.

[0032] As a preferred embodiment, the partial transmission refers to a transmittance of 1-10%.

[0033] As a preferred embodiment, the fundamental frequency light is a 1090nm wavelength laser, and the emitted light is a 545nm wavelength laser.

[0034] As a preferred embodiment, the laser crystal sheet is a rare-earth-doped calcium borate crystal exhibiting both laser and nonlinear optical effects, and its molecular formula is [insert molecular formula here]. or The laser crystal sheet is cut along the 545nm yellow-green non-critical phase-matching direction, with a cutting angle of θ=148.1° and φ=0°.

[0035] As a preferred embodiment, there are at least three pump sources, which are focused and homogenized by the light guide cone and enter the laser crystal sheet respectively. After laser frequency conversion and nonlinear frequency conversion, the output light is obtained.

[0036] As a preferred embodiment, the pump source is formed by a stacked array of at least 10 50W bar bars; the pump source is controlled and powered by a TTL circuit, with a power supply pulse width preferably between 0.5ms and 100ms, and the power supply pulse width is 20-40ms.

[0037] As a preferred embodiment, the heat-conducting fluid is pure water.

[0038] The present invention also provides a laser for anti-angiogenesis, used for the treatment of vascular skin diseases and anti-angiogenesis of scars, comprising a high-energy thermal capacity laser as described in any of the preceding claims.

[0039] It should be noted that the terms "high reflectivity" and "high transmittance" in this invention have their common meanings in the art. "High reflectivity" refers to a reflectivity greater than 90% for incident light of a specific wavelength or band. "High transmittance" refers to a transmittance greater than 80% for a specific wavelength or band.

[0040] The technical solution provided by this invention has the following advantages:

[0041] 1. The high-energy thermal capacity laser of the present invention includes a pump source, a light guide cone, and a laser crystal group, wherein there is at least one pump source for emitting pump light; the light guide cone is arranged in a one-to-one correspondence with the pump source for focusing the pump light; the laser crystal group is used to absorb the pump light focused by the light guide cone and to output laser light of a set wavelength; the high-energy thermal capacity laser of the present invention comprises several laser crystal sheets arranged in parallel from left to right to form a laser crystal group, and each laser crystal sheet is cut along a non-critical phase-matching direction of a set wavelength, the thickness in the light transmission direction is controlled at 1-3 mm, and the crystal area is greater than 10 mm × 10 mm; by depositing a dielectric film on different laser crystal sheets that make up the laser crystal group, the laser crystal sheets absorb the fundamental frequency light generated by the pump light, which passes through all the laser crystal sheets, and oscillates and doubles the frequency between the leftmost and rightmost laser crystal sheets, thereby generating frequency-doubled output light;

[0042] The high-energy thermal capacity laser of this invention does not use a single laser crystal block, but rather a laser crystal group composed of several laser crystal slices. A gap is provided between adjacent laser crystal slices to allow the passage of heat-conducting fluid, and a suitable coating is applied to each laser crystal slice. The laser crystal group operates by immersing itself in flowing heat-conducting fluid, achieving high-energy laser output and completely solving the defects of low thermal conductivity and low heat transfer efficiency of laser crystals. It also solves the problem of low output power or even laser crystal damage caused by poor heat transfer in traditional lasers. This high-energy thermal capacity laser of the present invention has high emission power and low cost, and can be used to treat vascular skin diseases, showing significant application prospects in fields such as biological detection, medical aesthetics, and scar treatment.

[0043] 2. The high-energy thermal capacity laser of the present invention can also be designed with several laser crystals arranged in a left-to-right direction, but with a certain angle of inclination between any two laser crystals. In this case, the coating strategy of the laser crystals is also changed accordingly, with the fundamental frequency light oscillating and frequency doubling within each individual laser crystal. After each laser crystal absorbs the pump light and generates the fundamental frequency light, it does not need to pass through all the laser crystals, but only needs to oscillate and double the frequency within each individual laser crystal. The frequency-doubled output light is then transmitted and output to the right. The high-energy thermal capacity laser of the present invention combines the output light from several individual laser crystals together to achieve high-energy output laser light.

[0044] 3. In the high-energy thermal capacity laser of this invention, the rightmost laser crystal plate has a dielectric film coated on its right side that is highly transparent to pump light, partially transparent to fundamental frequency light, and highly transparent to emitted light. This allows the laser emitted from the right side to simultaneously contain both fundamental and emitted light. Taking a 1090nm fundamental frequency laser and a 545nm emitted light as an example, when the right side of the last laser crystal plate is coated with a dielectric film that partially transmits the 1090nm fundamental frequency laser and is highly transparent to the 545nm emitted light, the laser emitted from the right side of the laser crystal plate contains both 545nm and 1090nm wavelengths. Since the 545nm laser is more suitable for treating superficial skin blood vessels, while the 1090nm laser is more suitable for treating deep skin blood vessels, using both together can treat skin with both superficial and deep skin blood vessels, resulting in higher treatment efficiency. The emergence of the high-energy 545nm and / or 1090nm yellow-green laser of the present invention fills the shortcoming of severe thermal effects in yellow light self-frequency doubling lasers, and has important application prospects in military, medical aesthetics and other fields.

[0045] 4. The present invention also provides a laser for anti-angiogenesis, used for the treatment of skin vascular diseases and anti-angiogenesis of scars, etc., comprising any of the high-energy thermal capacity lasers described above; since it comprises the high-energy thermal capacity lasers described above, it can output lasers with higher power and is less likely to damage the laser crystal, and has good market application prospects. Attached Figure Description

[0046] To more clearly illustrate the technical solutions in the prior art or specific embodiments of the present invention, the accompanying drawings used in the description of the prior art or specific embodiments are briefly introduced below.

[0047] Figure 1 These are the absorption curves of oxyhemoglobin and melanin to different wavelengths of laser light.

[0048] Figure 2 This is a schematic diagram of the high-energy thermal capacity laser in Embodiment 1 of the present invention.

[0049] Figure 3 This is a schematic diagram of the high-energy thermal capacity laser in Embodiment 2 of the present invention.

[0050] Figure reference numerals: 1. Pump source; 2. Light guide cone; 3. Laser crystal assembly; 31. Laser crystal sheet. Detailed Implementation

[0051] To enable those skilled in the art to better understand this solution, the technical solutions in the embodiments of this application will be clearly and completely described below with reference to the accompanying drawings. Obviously, the described embodiments are only some embodiments of this application, and not all embodiments. Based on the embodiments in this application, all other embodiments obtained by those skilled in the art without creative effort should fall within the scope of protection of this application.

[0052] It should be noted that the terms "first," "second," etc., used in this application are used to distinguish similar objects and not to describe a specific order or sequence. Furthermore, the terms "comprising" and "having," and any variations thereof, are intended to cover non-exclusive inclusion, such as a process, method, system, product, or device that includes a series of steps or units, not limited to those steps or units explicitly listed, but may also include other steps or units not explicitly listed or inherent to these processes, methods, products, or devices.

[0053] In this application, the terms "upper," "lower," "left," "right," "front," "rear," "top," "bottom," "inner," "outer," "middle," "vertical," "horizontal," "lateral," and "longitudinal" indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings. These terms are primarily for better description of this application and its embodiments, and are not intended to limit the indicated device, element, or component to having a specific orientation, or to be constructed and operated in a specific orientation. Furthermore, some of the above terms may be used to indicate other meanings besides orientation or positional relationship; for example, the term "upper" may also be used in some cases to indicate a certain dependency or connection relationship. Those skilled in the art can understand the specific meaning of these terms in this application according to the specific circumstances. In addition, the term "multiple" should mean two or more. It should be noted that, unless otherwise specified, the embodiments and features in the embodiments of this application can be combined with each other.

[0054] The present application will now be described in detail with reference to the accompanying drawings and embodiments.

[0055] Example 1

[0056] This embodiment provides a high-energy thermal capacity laser, such as Figure 1As shown, it includes: a pump source 1, a light guide cone 2, and a laser crystal group 3; wherein: there are 3 pump sources 1, which are used to emit pump light; there are also 3 light guide cones 2, which are arranged one-to-one with the pump sources 1, and are used to focus the pump light; the laser crystal group 3 is used to absorb the pump light focused by the light guide cone 2 and output laser light of a set wavelength.

[0057] The laser crystal group 3 includes several laser crystal slices 31, and each laser crystal slice 31 is cut along a non-critical phase matching direction of a set wavelength, with a thickness of 1-3 mm in the light transmission direction and an area greater than 10 mm × 10 mm.

[0058] In this embodiment, a plurality of laser crystal wafers 31 are arranged from left to right, and all the laser crystal wafers 31 are arranged parallel to each other. The light-transmitting surfaces of all the laser crystal wafers 31 are optically polished and coated. Among them: the leftmost laser crystal wafer 31 has a dielectric film with high transmittance to pump light, high reflectivity to fundamental frequency light, and high reflectivity to emitted light on its left side, and a dielectric film with high transmittance to pump light, high transmittance to fundamental frequency light, and high transmittance to emitted light on its right side; the rightmost laser crystal wafer 31 has a dielectric film with high transmittance to pump light, high transmittance to fundamental frequency light, and high transmittance to emitted light on its left side, and a dielectric film with high transmittance to pump light, high reflectivity or partial transmission to fundamental frequency light, and high transmittance to emitted light on its right side; the middle laser crystal wafer 31 has a dielectric film with high transmittance to pump light, high transmittance to fundamental frequency light, and high transmittance to emitted light on both sides.

[0059] There is a gap between any two adjacent laser crystal plates 31, which allows heat-conducting fluid to flow through; the laser crystal plates 31 are installed in a cooling container and immersed in the heat-conducting fluid, which circulates through the cooling container to cool the laser crystal plates 31.

[0060] In this embodiment, the laser crystal sheet 31 is a rare-earth-doped calcium borate crystal with laser effect and nonlinear optical effect, and its molecular formula is [insert molecular formula here]. or The laser crystal is cut along a 545nm yellow-green noncritical phase-matching direction at an angle of θ=148.1° and φ=0°. The fundamental frequency light is a 1090nm wavelength laser, and the emitted light is a 545nm wavelength laser.

[0061] In this embodiment, any two laser crystal plates 31 are arranged in parallel. The pump light emitted from the pump source 1 is focused and homogenized by the light guide cone 2 and then projected onto the laser crystal plates 31. Since several laser crystal plates 31 are arranged side by side and each is coated with a dielectric film that is highly transparent to the pump light, the pump light projected onto the laser crystal plates 31 will pass through multiple laser crystal plates 31. Each time it passes through a laser crystal plate 31, that laser crystal plate 31 can absorb the pump light and generate fundamental frequency light. The fundamental frequency light is oscillated and frequency-doubled between the leftmost laser crystal plate 31 and the rightmost laser crystal plate 31, forming the output light emitted from the right. Because multiple laser crystal plates 31 are arranged, the pump light can be absorbed layer by layer, and each can generate fundamental frequency light, which is then oscillated and frequency-doubled to generate output light. Therefore, the generation efficiency of the output light can be improved, and a higher-energy output laser can be produced.

[0062] A gap of 0.1mm-1mm is provided between any two adjacent laser crystal slices 31, allowing the heat-conducting fluid to flow through at a speed of 0.5m / s. This rapidly cools the laser crystal slices 31 immersed in the heat-conducting fluid, reducing the high heat generation caused by thermal lensing and thermally induced birefringence during high-power operation of the rare-earth-doped calcium borate crystal. In this embodiment, the heat-conducting fluid is pure water.

[0063] When the rightmost laser crystal plate 31 has a dielectric film on its right side that is highly transparent to pump light, partially transparent to fundamental frequency light, and highly transparent to emitted light, the laser emitted from the right side contains both fundamental and emitted light. Taking a 1090nm fundamental frequency laser and a 545nm emitted light as an example, when the right side of the last laser crystal plate is coated with a dielectric film that is partially transparent to the 1090nm fundamental frequency laser and highly transparent to the 545nm emitted light, the laser emitted from the right side contains both 545nm and 1090nm wavelengths. Since the 545nm laser is more suitable for treating superficial skin blood vessels, while the 1090nm laser is more suitable for treating deep skin blood vessels, using both together can treat skin with both superficial and deep skin blood vessels, resulting in higher treatment efficiency. The emergence of the high-energy 545nm and / or 1090nm yellow-green lasers in this embodiment fills the gap of severe thermal effects in yellow light self-frequency doubling lasers, and has important application prospects in military, medical aesthetics and other fields.

[0064] In this embodiment, the pump source 1 is formed by a stacked array of at least 10 50W bar bars. The pump source 1 is powered by a TTL circuit with a power supply pulse width of 0.5ms-100ms; preferably, the power supply pulse width is 20-40ms.

[0065] Example 2

[0066] This embodiment provides a high-energy thermal capacity laser, which is a variation of Embodiment 1, the difference being that any two laser crystal plates 31 are tilted at a certain angle (see reference). Figure 3 As shown in the figure, the coating strategy of the laser crystal is also changed accordingly, so that the fundamental frequency light oscillates and doubles within each individual laser crystal 31.

[0067] Specifically, the included angle between any two adjacent laser crystal slices 31 is 0-10'.

[0068] The coating strategy is adjusted as follows: the left side of the leftmost laser crystal sheet 31 is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly reflective to the emitted light; the right side is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the emitted light. The left side of the rightmost laser crystal sheet 31 is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the emitted light; the right side is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, or partially transparent to the emitted light. The left side of the middle laser crystal sheet 31 is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the emitted light; the right side is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the emitted light.

[0069] With the laser crystal group 3 configured as described above, after each laser crystal 31 absorbs the pump light and generates the fundamental frequency light, it does not need to pass through all the laser crystal 31, but only needs to oscillate and double the frequency within each individual laser crystal 31. The frequency-doubled output light is then transmitted and output to the right. The high-energy thermal capacity laser of this embodiment combines the output light from several individual laser crystal 31s together to achieve high-energy output laser light.

[0070] Example 3

[0071] This embodiment provides a laser for anti-angiogenesis, used in the treatment of skin vascular diseases and anti-angiogenesis of scars. The laser uses the high-energy thermal capacity laser described in Embodiment 1 or 2.

[0072] Anti-angiogenesis refers to a therapeutic strategy that intervenes in the growth of diseased or abnormal tissue by inhibiting the formation of new blood vessels. There is generally a relationship between angiogenesis and scar formation: in the early stages of wound healing, new blood vessels provide oxygen and nutrients for tissue repair, while in pathological scars (such as hypertrophic scars and keloids), angiogenesis may be overactive. These new blood vessels not only provide additional nutrients to the scar but also release pro-inflammatory and growth factors (such as VEGF and TGF-β), stimulating fibroblast proliferation and excessive collagen deposition, leading to scar thickening and hardening.

[0073] The laser in this embodiment can inhibit angiogenesis, reduce blood supply to scars, block the nutrient source of scar tissue, and limit its growth; it can regulate inflammation and fibrosis, inhibit pro-angiogenic factors (such as VEGF) while reducing inflammatory mediators and collagen synthesis, and promote scar softening; it can also promote scar maturation, transforming excessively proliferating scars into normal tissue.

[0074] Because of the use of the high-energy thermal capacity laser in the above embodiments, it has all the advantages that come with using the above laser.

[0075] Obviously, the above embodiments are merely illustrative examples for clear explanation and are not intended to limit the implementation. Those skilled in the art can make other variations or modifications based on the above description. It is neither necessary nor possible to exhaustively list all possible implementations here. However, obvious variations or modifications derived therefrom are still within the protection scope of this innovative technical solution.

Claims

1. A high-energy thermal capacity laser, comprising: A pump source (1), at least one, is used to emit pump light; A light guide cone (2) is provided in a one-to-one correspondence with the pump source (1) to focus the pump light; The laser crystal group (3) is used to absorb the pump light focused by the light guide cone (2) and output laser light of a set wavelength; Its features are: The laser crystal group (3) includes several laser crystal slices (31), and any one of the laser crystal slices (31) is cut along the non-critical phase matching direction of a set wavelength, with a thickness of 1-3 mm in the light transmission direction and an area greater than 10 mm × 10 mm. Several laser crystal wafers (31) are arranged from left to right, and any two laser crystal wafers (31) are tilted at a certain angle. The light-transmitting surfaces of all the laser crystal wafers (31) are optically polished and coated, wherein: The left side of the leftmost laser crystal (31) is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly reflective to the emitted light, and the right side is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the emitted light. The rightmost laser crystal chip (31) has a dielectric film on its left side that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the emitted light, and a dielectric film on its right side that is highly transparent to the pump light, highly reflective to the fundamental frequency light or partially transparent to the emitted light. The left side of the intermediate laser crystal (31) is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the emitted light; the right side is coated with a dielectric film that is highly transparent to the pump light, highly reflective to the fundamental frequency light, and highly transparent to the emitted light. There is a gap between any two adjacent laser crystal sheets (31) that allows thermally conductive fluid to flow through; The laser crystal (31) is installed in a cooling container and immersed in the heat-conducting fluid, which circulates through the cooling container to cool the laser crystal (31).

2. The high-energy thermal capacity laser according to claim 1, characterized in that: The included angle between any two adjacent laser crystal sheets (31) is greater than 0 and less than 10'.

3. The high-energy thermal capacity laser according to claim 1, characterized in that: The term "partial transmission" refers to a transmittance between 1% and 10%.

4. The high-energy thermal capacity laser according to any one of claims 1-3, characterized in that: The fundamental frequency light is a 1090nm wavelength laser, and the emitted light is a 545nm wavelength laser.

5. The high-energy thermal capacity laser according to any one of claims 1-3, characterized in that: The laser crystal sheet (31) is a rare earth ion-doped calcium borate crystal with laser effect and nonlinear optical effect, and the molecular formula is Yb:YCa4O(BO3)3 or Nd:YCa4O(BO3)3. The laser crystal sheet is cut along the 545nm yellow-green noncritical phase matching direction, and the cutting angle is θ=148.1°, φ=0°.

6. The high-energy thermal capacity laser according to any one of claims 1-3, characterized in that: The pump source (1) consists of at least three sources, which are focused and homogenized by the light guide cone (2) and enter the laser crystal (31) respectively. After laser frequency conversion and nonlinear frequency conversion, the output light is obtained.

7. The high-energy thermal capacity laser according to any one of claims 1-3, characterized in that: The pump source (1) is formed by a stacked array of at least 10 50W bar bars; the pump source is powered by a TTL circuit and the power supply pulse width is 0.5ms-100ms.

8. The high-energy thermal capacity laser according to claim 7, characterized in that: The power supply pulse width is 20-40ms.

9. The high-energy thermal capacity laser according to any one of claims 1-3, characterized in that: The heat-conducting fluid is pure water.

10. A laser for anti-angiogenesis, used in the treatment of vascular skin diseases and scar anti-angiogenesis, characterized in that, It includes a high-energy thermal capacity laser as described in any one of claims 1-9.

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