Low molecular weight heparin solution pre-filled integrated hemodialysis injector

Abstract

The present invention provides a low molecular weight heparin liquid pre-filled integrated hemodialysis syringe, including a syringe, a piston, an empty needle nipple, a sealing box, a low molecular weight heparin liquid bag and a liquid bag extrusion mechanism; the side wall of the syringe is provided with a liquid inlet, and the sealing box is arranged outside the side of the syringe close to the liquid inlet; the liquid bag extrusion mechanism includes an upper limit plate, a lower pressure plate and a clamping plate; the middle part of the upper limit plate is arranged from front to back into an arc groove I with a high front and a low back, and the middle part of the lower pressure plate is arranged from front to back into an arc groove II with a high front and a low back; the outer side of the bottom of the syringe is also provided with a rotating drive mechanism for driving the lower pressure plate to rotate around a rotating shaft; a drug mixing interface and an infusion interface are arranged on one end of the bag body, a one-way valve is arranged on the infusion interface, and the end of the infusion interface is clamped into the liquid inlet. After the hemodialysis syringe is connected to the catheter connector, the entire withdrawal and injection of low molecular weight heparin are in a sealed state, which greatly reduces the risk of exposure to the air.

Description

Technical Field

[0001] The invention relates to the technical field of hemodialysis, and in particular to a hemodialysis syringe pre-filled with low-molecular-weight heparin liquid. Background Art

[0002] Before the start of hemodialysis, a sufficient amount of heparin is administered intravenously, and then a certain additional dose is given every hour based on the blood phosphorus index to prevent circulating blood from clotting.

[0003] Heparin solution is prepared and used immediately, according to the dosage. For example, the dosage of low molecular weight heparin is 0.4 vials, which is prepared by drawing 4 ml of saline with an empty needle. Existing heparin injection packaging generally uses vials or ampoules. When preparing the solution, a syringe is used to transfer the drug. In this way, the needle of the syringe is completely exposed to the air during the entire preparation process, which is easy to cause drug contamination.

[0004] In order to overcome the above defects, patent CN 113633549A discloses an ampoule bottle mixing card body and a closed dispensing infusion connector. When using the ampoule bottle mixing card body, the ampoule bottle mixing card body is matched with the infusion connector holder, the broken ampoule bottle is inserted into the upper part of the ampoule bottle mixing cup body, and then the lower end puncture needle of the hollow needle is inserted into the puncture hole of the infusion cover to achieve a closed connection between the ampoule bottle and the infusion soft bag, which greatly reduces the risk of the drug solution being exposed to the air during the mixing process.

[0005] Although the above patent solves the risk of the drug solution being exposed to the air during the mixing process in the prior art, when used in the dialysis clinical field, an empty needle is still needed to first draw the heparin solution in the soft bag into the syringe, and then inject the heparin solution in the syringe into the catheter. When the puncture needle is inserted into the sealing rubber plug on the puncture connector, debris will be generated from the sealing rubber plug during the puncture process, and then enter the syringe. In addition, the heparin solution in the soft bag is drawn into the syringe with an empty needle, which is also in an exposed state and is prone to contamination of the drug solution. Summary of the invention

[0006] In view of the above-mentioned deficiencies in the prior art, the present invention provides a low molecular weight heparin liquid pre-filled integrated hemodialysis syringe which reduces liquid contamination.

[0007] In order to solve the above technical problems, the present invention adopts the following technical solutions:

[0008] A low-molecular-weight heparin liquid pre-filled integrated hemodialysis syringe comprises an injection syringe, a piston, an empty needle nipple arranged on the front end of the injection syringe, a sealing box, a low-molecular-weight heparin liquid bag arranged in the sealing box, and a liquid bag squeezing mechanism;

[0009] A liquid inlet is arranged at one end of the side wall of the injection syringe close to the empty needle nipple, and the sealing box is arranged outside the side of the injection syringe close to the liquid inlet;

[0010] The sealed box comprises a front side plate, a left side plate, a right side plate, a rear side plate and a bottom plate, the tops of the front side plate and the rear side plate are both arranged in an arc shape and adapted to the outer bottom of the injection syringe, and the bottom side wall of the injection syringe is sealed and butted with the tops of the front side plate, the left side plate, the right side plate and the rear side plate;

[0011] The medicine bag squeezing mechanism comprises an upper limit plate, a lower pressure plate and a clamping plate; the upper limit plate is fixedly arranged between the left plate and the right plate, the middle part of the upper limit plate is arranged from front to back into an arc-shaped groove I with a high front and a low back, the lower pressure plate is arranged below the upper limit plate, the inner side of the front side plate is horizontally arranged with a rotating shaft parallel to the front side plate near the top, the front end of the lower pressure plate is sleeved on the rotating shaft, and the middle part of the lower pressure plate is arranged from front to back into an arc-shaped groove II with a high front and a low back; a rotating driving mechanism for driving the lower pressure plate to rotate around the rotating shaft is also arranged on the outer side of the bottom of the injection syringe; when the lower pressure plate rotates to the uppermost position, the upper surface of the arc-shaped groove II of the lower pressure plate and the bottom of the arc-shaped groove I of the upper limit plate are mutually fitted; the clamping plate is horizontally arranged on the inner side of the front side plate and located above the front end of the lower pressure plate, the clamping plate is located on the front side of the upper limit plate, and a fixed clamping position for a drug mixing interface and a clamping position for an infusion interface are arranged on the clamping plate;

[0012] A drug mixing interface and an infusion interface are provided on one end of the bag body of the low molecular weight heparin liquid bag, and a one-way valve is provided on the infusion interface; the low molecular weight heparin liquid bag is placed in the arc groove II of the lower pressure plate, the drug mixing interface is clamped in the drug mixing interface fixed clamping position, the infusion interface is clamped in the infusion interface clamping position, the end of the infusion interface is clamped in the liquid inlet, and the outer wall of the end of the infusion interface is sealed with the inner wall of the liquid inlet.

[0013] As a preferred embodiment of the present invention, the rotation drive mechanism includes a pull rod, a pull rope I and a pull rope II; the pull rod is arranged below the bottom of the injection syringe, the axis of the pull rod is parallel to the axis of the injection syringe, the front end of the pull rod passes through the rear side plate and extends into the sealing box, the pull rod slides and seals with the rear side plate in the front-to-back direction, the front end of the pull rod extends to the upper rear end of the upper limit plate, one end of the pull rope I is connected to the rear end of the lower pressure plate, and the other end of the pull rope I is connected to the front end of the pull rod; one end of the pull rope II is connected to the rear end of the pull rod, and the other end of the pull rope II is detachably connected to the rear end of the piston.

[0014] As a preferred embodiment of the present invention, the rotation drive mechanism also includes a guide sleeve, which is arranged below the bottom of the injection syringe and between the rear side plate and the rear end of the injection syringe, the axis of the guide sleeve is parallel to the axis of the injection syringe, and the pull rod passes through the guide sleeve and slides with the guide sleeve.

[0015] As a preferred solution of the present invention, a filter membrane is provided near the inner side of the infusion interface.

[0016] As a preferred solution of the present invention, a limit block is provided at the rear end of the pull rod to prevent the rear end of the pull rod from sliding into the guide sleeve, and the lateral dimension of the limit block is larger than the inner diameter of the guide sleeve.

[0017] As a preferred solution of the present invention, a through hole I is provided at the rear end of the upper limit plate in the vertical direction, and the pull rope I passes through the through hole I.

[0018] As a preferred solution of the present invention, the sealed box is a transparent sterile sealed box.

[0019] As a preferred solution of the present invention, a connecting sealing sleeve is provided outside the empty needle nipple, and an internal thread matching the external thread on the catheter connector is provided on the inner wall of the connecting sealing sleeve near the rear side, the rear end of the connecting sealing sleeve is rotatably and sealingly connected to the rear end of the empty needle nipple, and a sealing membrane is provided at the front end of the connecting sealing sleeve.

[0020] As a preferred solution of the present invention, a sterile cotton sleeve is arranged on the inner wall of the connecting sealing sleeve near the front side, and the outer wall of the sterile cotton sleeve is in close contact with the inner wall of the connecting sealing sleeve.

[0021] As a preferred solution of the present invention, the connecting sealing sleeve is composed of two semicircular sleeves, one side of the two semicircular sleeves is rotatable and sealed, and the other side of the two semicircular sleeves is sealed by mutually buckled connecting belts.

[0022] Compared with the prior art, the present invention has the following beneficial effects:

[0023] 1. Before hemodialysis, when it is necessary to inject heparin into the vein through the catheter, tear off the sealing film on the connecting sealing sleeve, and immediately screw the connecting sealing sleeve onto the catheter joint, which not only disinfects the catheter joint, but also makes the catheter joint in a sealed connection without being contaminated. When injecting heparin intravenously, first withdraw blood. Simply remove the rear end of the pull rope II from the rear end of the piston to withdraw a certain amount of blood. After the withdrawal is completed, clamp the catheter, and then connect the rear end of the pull rope II to the rear end of the piston. Continue to push the piston backward. The low molecular weight heparin solution is filtered by the filter membrane and enters the injection syringe through the one-way valve. Then open the tube clamp on the catheter and push the piston forward. The low molecular weight heparin solution and blood in the syringe can be injected into the vein through the catheter, thereby preventing the circulating blood from coagulating. The entire withdrawal and injection of low molecular weight heparin solution operations are in a sealed state.

[0024] 2. Only one integrated hemodialysis syringe with low molecular weight heparin solution pre-filled is needed to be connected to the catheter connector to complete the two steps of blood withdrawal and low molecular weight heparin injection. The entire withdrawal and injection of low molecular weight heparin solution are in a sealed state, which greatly reduces the risk of blood and low molecular weight heparin solution being exposed to the air during the withdrawal and injection process, and greatly improves the safety of clinical medication.

[0025] 3. The present invention provides a connecting sealing sleeve outside the empty needle nipple. When the empty needle nipple is inserted into the catheter connector, the catheter connector is pushed and disinfected using the sterilizing cotton sleeve in the connecting sealing sleeve. There is no need to manually disinfect the catheter connector separately, which further ensures that the catheter connector is not contaminated or reduces the chance of contamination of the catheter connector. At the same time, the empty needle nipple is also placed in a sealed and sterile connecting sealing sleeve. BRIEF DESCRIPTION OF THE DRAWINGS

[0026] Figure 1 It is a schematic diagram of the cross-sectional structure of a low molecular weight heparin solution pre-filled integrated hemodialysis syringe;

[0027] Figure 2 yes Figure 1 A schematic diagram of the enlarged structure at A in the middle;

[0028] Figure 3 This is a schematic diagram of the structure of the front side panel of the sealing box after it is removed;

[0029] Figure 4 It is a schematic diagram of the structure in which the lower pressing plate and the clamping plate are arranged on the front side plate;

[0030] Figure 5 It is a schematic diagram of the structure in which a rotating shaft is arranged on the front side plate;

[0031] Figure 6 It is a structural schematic diagram of the lower pressure plate;

[0032] Figure 7 It is a schematic diagram of the structure of the bag;

[0033] Figure 8 It is a structural schematic diagram of unscrewing the sealing cap on the infusion interface on the bag body;

[0034] Fig. 9 It is a structural schematic diagram of the connection sealing sleeve;

[0035] Fig.10 It is a schematic diagram of the cross-sectional structure of the connection sealing sleeve;

[0036] Fig.11 The present invention is a structural schematic diagram of the sealed docking of a low-molecular-weight heparin solution pre-filled integrated hemodialysis syringe and a catheter connector.

[0037] In the figure: 1-injection syringe; 11-liquid inlet; 2-piston; 3-empty needle nipple; 4-sealed box; 41-front side plate; 42-left side plate; 43-right side plate; 44-rear side plate; 45-bottom plate; 5-low molecular weight heparin liquid bag; 51-drug mixing interface; 52-infusion interface; 53-check valve; 54-filter membrane; 55-bag body; 6-liquid bag squeezing mechanism; 61-upper limit plate; 62-lower pressure plate; 6 3—card plate; 631—fixed position of drug mixing interface; 632—card position of infusion interface; 64—rotating shaft; 65—through hole; 66—positioning block; 67—through hole II; 7—rotation driving mechanism; 71—pull rod; 72—pull rope I; 73—pull rope II; 74—guide sleeve; 75—limiting block; 8—connecting sealing sleeve; 81—internal thread; 82—sealing film; 83—sterilized cotton sleeve; 84—connecting belt; 9—catheter connector. DETAILED DESCRIPTION

[0038] The present invention is described in detail below in conjunction with embodiments and drawings.

[0039] like Figure 1 As shown, the low molecular weight heparin liquid pre-filled integrated hemodialysis syringe comprises an injection syringe 1, a piston 2, an empty needle nipple 3 arranged on the front end of the injection syringe 1, a sealing box 4, and a low molecular weight heparin liquid bag 5 and a liquid bag squeezing mechanism 6 arranged in the sealing box 4. In this embodiment, the front side refers to the side facing the empty needle nipple 3 of the syringe 1, and the rear side refers to the side away from the empty needle nipple 3 of the syringe 1. A liquid inlet 11 is arranged on the side wall of the injection syringe 1 close to the empty needle nipple 3, and the sealing box 4 is arranged outside the side of the injection syringe 1 close to the liquid inlet 11, as shown in FIG. Figure 1 and Figure 2 shown.

[0040] The sealed box 4 includes a front side plate 41, a left side plate 42, a right side plate 43, a rear side plate 44 and a bottom plate 45. Figure 1 , Figure 3 and Figure 4The tops of the front side plate 41 and the rear side plate 44 are both configured to be arc-shaped and adapted to the outer bottom of the injection syringe 1 , and the bottom side wall of the injection syringe 1 is sealed and butted with the tops of the front side plate 41 , the left side plate 42 , the right side plate 43 and the rear side plate 44 . In this embodiment, the left side plate 42, the right side plate 43, the rear side plate 44 and the bottom plate 45 are fixedly connected to form a whole, the front side plate 41 is connected to the front ends of the left side plate 42, the right side plate 43 and the bottom plate 45 by interlocking, and the front ends of the left side plate 42, the right side plate 43 and the bottom plate 45 are all provided with a sealing layer. After the buckling connection, the front side plate 41 is sealed with the front ends of the left side plate 42, the right side plate 43 and the bottom plate 45, and the tops of the front side plate 41, the left side plate 42, the right side plate 43 and the rear side plate 44 are also provided with a sealing layer. After the bottom side wall of the injection syringe 1 is sealed and connected to the tops of the front side plate 41, the left side plate 42, the right side plate 43 and the rear side plate 44, the sealed box 4 can be in a sealed state. The connection method between the front side panel 41 and the front ends of the left side panel 42, the right side panel 43 and the bottom panel 45, as well as the connection method between the bottom side wall of the injection syringe 1 and the top of the front side panel 41, the left side panel 42, the right side panel 43 and the rear side panel 44 can be connected by either snap-fitting or snap-fitting. The connection method is a conventional technical means for those skilled in the art, so it will not be described in detail.

[0041] The liquid medicine bag squeezing mechanism 6 includes an upper limit plate 61, a lower pressure plate 62 and a clamping plate 63. Figure 1 , Figure 3 and Figure 4 The upper limit plate 61 is fixedly arranged between the left side plate 42 and the right side plate 43. The middle part of the upper limit plate 61 is arranged from front to back to form an arc-shaped groove I with a high front and a low rear, as shown in FIG. Figure 3 As shown, the arc groove I is a sliding groove from front to back. The lower pressing plate 62 is arranged below the upper limit plate 61. A rotating shaft 64 parallel to the front side plate 41 is arranged horizontally on the inner side of the front side plate 41 near the top. Positioning blocks 66 are fixedly arranged on the inner side of the front side plate 41 and on both sides of the rotating shaft 64. The two ends of the rotating shaft 64 are connected to the left and right positioning blocks 66. Figure 5 As shown, a through hole 65 is provided at the front end of the lower pressing plate 62. Figure 6 As shown, the lower pressing plate 62 is sleeved on the rotating shaft 64 through the through hole 65 thereon and rotates with the rotating shaft 64. The middle part of the lower pressing plate 62 is arranged from front to back to form an arc groove II with a high front and a low rear. The outer side of the bottom of the injection syringe 1 is also provided with a rotation driving mechanism 7 for driving the lower pressing plate 62 to rotate around the rotating shaft 64, as shown in FIG. Figure 1As shown. When the lower pressing plate 62 is rotated to the uppermost position by the rotating driving mechanism 7, the upper surface of the arc groove II of the lower pressing plate 62 fits with the bottom of the arc groove I of the upper positioning plate 61. If the low molecular weight heparin liquid bag 5 is placed on the lower pressing plate 62, the low molecular weight heparin liquid in the low molecular weight heparin liquid bag 5 can be squeezed out of the one-way valve 53 by squeezing the upper positioning plate 61 and the lower pressing plate 62. The card plate 63 is horizontally arranged on the inner side of the front side plate 41 and is located above the front end of the lower pressing plate 62. The card plate 63 is located on the front side of the upper positioning plate 61. The card plate 63 is provided with a drug mixing interface fixing position 631 and an infusion interface fixing position 632, as shown Figure 4 and Figure 5 shown.

[0042] The bag body 55 of the low molecular weight heparin liquid bag 5 is provided with a drug mixing interface 51 and a liquid infusion interface 52 at one end. The structure of the bag body 55 is as follows: Figure 7 As shown, a one-way valve 53 is arranged on the infusion interface 52. The bag body 55, the drug mixing interface 51 and the infusion interface 52 are all prior art. The present invention adds a one-way valve 53 to the existing infusion interface 52, and the length of the infusion interface 52 is longer than that of the drug mixing interface 51. When using the bag body 55, first unscrew the sealing cap on the drug mixing interface 51 to mix the low molecular weight heparin with the physiological saline in the bag body 55. After the mixed low molecular weight heparin liquid enters the bag body 55, screw on the sealing cap on the drug mixing interface 51, and then unscrew the sealing cap on the infusion interface 52 to make the one-way valve 53 communicate with the outside of the drug mixing interface 51. Figure 8 As shown, finally, the low molecular weight heparin liquid bag 5 is placed in the arc groove II of the lower pressure plate 62, the drug mixing interface 51 is clamped in the drug mixing interface fixed clamping position 631, the infusion interface 52 is clamped in the infusion interface clamping position 632, the end of the infusion interface 52 is clamped in the liquid inlet 11, and the outer wall of the end of the infusion interface 52 is sealed with the inner wall of the liquid inlet 11, as shown in FIG. Figure 2 shown.

[0043] The rotation driving mechanism 7 includes a pull rod 71, a pull rope I 72, a pull rope II 73 and a guide sleeve 74. Figure 1The pull rod 71 is arranged below the bottom of the injection syringe 1, and the axis of the pull rod 71 is parallel to the axis of the injection syringe 1. The guide sleeve 74 is also arranged below the bottom of the injection syringe 1 and is located between the rear side plate 44 and the rear end of the injection syringe 1. The axis of the guide sleeve 74 is parallel to the axis of the injection syringe 1. The pull rod 71 passes through the guide sleeve 74 and slides with the guide sleeve 74. The guide sleeve 74 plays a supporting role and a guiding role for the pull rod 71. The front end of the pull rod 71 passes through the rear side plate 44 and extends into the sealed box 4. The pull rod 71 slides with the rear side plate 44 in the front-to-back direction and is sealed. The front end of the pull rod 71 extends to the upper rear end of the upper limit plate 61. The rear end of the upper limit plate 61 is provided with a through hole I in the vertical direction. The rear end of the lower pressure plate 62 is also provided with a through hole II 67 in the vertical direction. The pull rope I 72 passes through the through hole I and the through hole II 67. The bottom end of the pull rope I 72 is connected to the bottom of the through hole II 67 of the lower pressure plate 62, and the top end of the pull rope I 72 is connected to the front end of the pull rod 71. The rear end of the pull rod 71 is provided with a limit block 75 to prevent the rear end of the pull rod 71 from sliding into the guide sleeve 74. The lateral dimension of the limit block 75 is larger than the inner diameter of the guide sleeve 74. One end of the drawstring II 73 is connected to the rear end of the pull rod 71, and the other end of the drawstring II 73 is detachably connected to the rear end of the piston 2. A drawstring hole can be formed on the rear end of the piston 2, and a rotatable clamping block for fixing the drawstring II 73 in the drawstring hole is provided on the rear end of the piston 2. When the rear end of the drawstring II 73 passes through the drawstring hole, the rear end of the drawstring II 73 can be fixed in the drawstring hole by rotating the clamping block. When the rear end of the drawstring II 73 is connected to the rear end of the piston 2, the piston 2 is moved backward, and the lower pressing plate 62 can be driven to rotate by the rotating driving mechanism 7, thereby squeezing the low molecular weight heparin solution in the low molecular weight heparin solution bag 5 into the injection syringe 1 through the one-way valve 53. When the rear end of the drawstring II 73 is not connected to the rear end of the piston 2, it can be used as an ordinary syringe.

[0044] A filter membrane 54 is provided near the inner side of the infusion interface 52. In the process of mixing medicines, glass chips are inevitably generated when breaking the bottleneck of the ampoule bottle, or rubber plug chips are inevitably generated when puncturing the sealing plug on the cillin bottle, or rubber plug chips are also inevitably generated when puncturing the sealing plug on the physiological saline bag. Once the glass chips or rubber plug chips enter the low molecular weight heparin liquid bag 5, when squeezing the low molecular weight heparin liquid bag 5, the low molecular weight heparin liquid passes through the filter membrane 54 and then enters the injection syringe 1 through the one-way valve 53. The filter membrane 54 can filter out the glass chips or rubber plug chips, effectively preventing the glass chips or rubber plug chips from entering the injection syringe 1. The sealing box 4 is a transparent sterile sealing box. When using the low molecular weight heparin liquid pre-set integrated hemodialysis syringe, the pulling conditions of the low molecular weight heparin liquid bag 5, the liquid bag squeezing mechanism 6 and the rotating drive mechanism 7 in the sealing box 4 can be checked at any time.

[0045] The hollow needle nipple 3 is provided with a connecting sealing sleeve 8, and the structure of the connecting sealing sleeve 8 is as follows: Fig. 9 and Fig.10 As shown, the inner wall of the connecting sealing sleeve 8 is provided with an internal thread 81 matching with the external thread on the catheter connector 9 near the rear side, the rear end of the connecting sealing sleeve 8 is rotatably and sealingly connected to the rear end of the empty needle nipple 3, and the front end of the connecting sealing sleeve 8 is provided with a sealing film 82. A sterilizing cotton sleeve 83 is provided on the inner wall of the connecting sealing sleeve 8 near the front side, and the outer wall of the sterilizing cotton sleeve 83 is tightly fitted with the inner wall of the connecting sealing sleeve 8. The sealing film 82 makes the inside of the connecting sealing sleeve 8 in a sealed state, which can ensure that it is in a sterile state during the docking process and use. When in use, tear off the sealing film 82, unscrew the iodine cap on the catheter connector 9, put the connecting sealing sleeve 8 on the catheter connector 9, and sterilize the catheter connector 9 during the process of inserting the sterilizing cotton sleeve 83 on the connecting sealing sleeve 8 on the catheter connector 9, and then rotate the connecting sealing sleeve 8 so that the internal thread 81 in the connecting sealing sleeve 8 is screwed onto the external thread on the catheter connector 9, as shown in FIG. Fig.11 As shown, the syringe 1 and the catheter connector 9 are aseptically connected. A connection sealing sleeve 8 is provided outside the empty needle nipple 3. When the empty needle nipple 3 is inserted into the catheter connector 9, the sealing film 82 is torn off, and the catheter connector 9 is pushed-disinfected using the sterile cotton sleeve 83 in the connection sealing sleeve 8. The connection sealing sleeve 8 is further rotated to be pushed onto the catheter connector 9, which not only disinfects the front end of the catheter connector 9, but also allows the front end of the catheter connector 9 to be covered in the connection sealing sleeve 8. At the same time, the empty needle nipple 3 is placed in the sealed and sterile connection sealing sleeve 8 without being contaminated, further reducing the probability of contamination of the catheter connector 9.

[0046] The connection sealing sleeve 8 is composed of two semicircular sleeves, one side of which can be rotatably sealed and connected, and the other side of which is sealed and connected by a mutually buckled connection belt 84. After the low molecular weight heparin liquid pre-filled integrated hemodialysis syringe is used, the connection belt 84 is untied, the two semicircular sleeves can be rotated outward, the connection sealing sleeve 8 is removed from the catheter connector 9, and finally the empty needle nipple 3 is pulled out from the catheter connector 9, thereby preventing the connection sealing sleeve 8 from being rotated and removed from the catheter connector 9, and further preventing the connection sealing sleeve 8 from being rotated backward to be removed and contaminating the catheter connector 9.

[0047] Before using the low molecular weight heparin solution pre-set integrated hemodialysis syringe, first mix the low molecular weight heparin with the physiological saline in the bag body 55 in the sealed sterile box of the dispensing room, tighten the sealing cap on the mixing interface 51, and then unscrew the sealing cap on the infusion interface 52, place the low molecular weight heparin solution bag 5 on the lower pressure plate 62, the mixing interface 51 on the low molecular weight heparin solution bag 5 is clamped on the mixing interface fixed clamping position 631, and the infusion interface 52 is clamped on the infusion interface clamping position 632, and then the front side plate 41 is sealed and connected with the front end of the left side plate 42, the right side plate 43 and the bottom plate 45, the bottom side wall of the injection syringe 1 is sealed and connected with the top of the front side plate 41, the left side plate 42, the right side plate 43 and the rear side plate 44, and the end of the infusion interface 52 is clamped in the liquid inlet 11, and the entire injection syringe 1 and the sealing box 4 are in a sealed and sterile state.

[0048] When hemodialysis needs to inject heparin into the catheter, the hemodialysis syringe with pre-installed low molecular weight heparin solution is brought to the bedside, the sealing film 82 on the connecting sealing sleeve 8 is torn off, the iodine cap on the catheter connector 9 is unscrewed, and the connecting sealing sleeve 8 is immediately put on the catheter connector 9, the empty needle nipple 3 is inserted into the catheter connector 9, and the connecting sealing sleeve 8 is screwed in and put in, so that the catheter connector 9 is disinfected and the catheter connector 9 is placed in the connecting sealing sleeve 8 without being contaminated. When injecting heparin intravenously, first draw back blood, remove the rear end of the pull rope II 73 from the rear end of the piston 2, push the piston 2 backward, draw back a certain amount of blood, check the amount of blood drawn back to determine whether the venous puncture is correct, and after confirming that the venous puncture is correct, clamp the catheter, then connect the rear end of the pull rope II 73 to the rear end of the piston 2, and continue to push the piston 2 backward. The pull rope II 73 pulls the pull rod 71 to move backward, and the pull rope I 72 simultaneously pulls the lower pressure plate 62 to rotate around the rotating shaft 64, the upper limit plate 61 and the lower pressure plate 62 squeeze the low molecular weight heparin liquid bag 5, and the one-way valve 53 opens. When the piston 2 is pushed backward, it also squeezes the low molecular weight heparin liquid bag 5. The low molecular weight heparin liquid bag 5 forms suction, and the low molecular weight heparin liquid in the low molecular weight heparin liquid bag 5 is filtered by the filter membrane 54 and then enters the injection syringe 1 through the one-way valve 53. When the lower pressure plate 62 rotates to the uppermost position, the lower pressure plate 62 completely presses the two sides of the low molecular weight heparin liquid bag 5 against the bottom of the upper limit plate 61. At this time, the low molecular weight heparin liquid in the low molecular weight heparin liquid bag 5 is completely pressed into the injection syringe 1. At this time, the one-way valve 53 is closed, the tube clamp on the catheter is opened, and the piston 2 is pushed forward, and the low molecular weight heparin liquid and blood in the injection barrel 1 are injected into the vein through the catheter again, thereby preventing the circulating blood from clotting.

[0049] The present invention only requires one low molecular weight heparin solution pre-installed integrated hemodialysis syringe to be connected to the catheter connector 9, and the entire withdrawal and injection of the low molecular weight heparin solution are in a sealed state, which greatly reduces the risk of blood and low molecular weight heparin solution being exposed to the air during the withdrawal and injection process, and greatly improves the safety of clinical medication.

[0050] Finally, it should be noted that the above embodiments are only used to illustrate the technical solution of the present invention rather than to limit it. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solution of the present invention can be modified or replaced by equivalents without departing from the purpose and scope of the technical solution of the present invention, which should be included in the scope of the claims of the present invention.

Claims

1. A low molecular weight heparin liquid pre-filled integrated hemodialysis syringe, comprising an injection syringe (1), a piston (2) and an empty needle nipple (3) arranged on the front end of the injection syringe (1), characterized in that: It also includes a sealed box (4), a low molecular weight heparin drug bag (5) and a drug bag squeezing mechanism (6) arranged in the sealed box (4); A liquid inlet (11) is arranged on one end of the side wall of the injection syringe (1) close to the empty needle nipple (3), and the sealing box (4) is arranged outside the side of the injection syringe (1) close to the liquid inlet (11); The sealed box (4) comprises a front side plate (41), a left side plate (42), a right side plate (43), a rear side plate (44) and a bottom plate (45); the tops of the front side plate (41) and the rear side plate (44) are both arranged in an arc shape and adapted to the outer bottom of the injection syringe (1); the bottom side wall of the injection syringe (1) is sealed and butted with the tops of the front side plate (41), the left side plate (42), the right side plate (43) and the rear side plate (44); The liquid medicine bag squeezing mechanism (6) comprises an upper limit plate (61), a lower pressure plate (62) and a clamping plate (63); the upper limit plate (61) is fixedly arranged between the left side plate (42) and the right side plate (43); the middle part of the upper limit plate (61) is arranged from front to back to form an arc-shaped groove I with a front high and a rear low; the lower pressure plate (62) is arranged below the upper limit plate (61); a rotating shaft (64) parallel to the front side plate (41) is horizontally arranged on the inner side of the front side plate (41) near the top; the front end of the lower pressure plate (62) is sleeved on the rotating shaft (64); the middle part of the lower pressure plate (62) is arranged from front to back to form a front high and a rear low arc-shaped groove I with ... high arc-shaped groove I with a front high and a rear low arc-shaped groove I with a front high and a rear high arc-shaped groove I with a front high and a rear low arc-shaped groove I with a front high and a rear high arc-shaped groove I with a front high and a rear low arc-shaped The bottom of the injection syringe (1) is provided with an arc-shaped groove II; the outer side of the bottom of the injection syringe (1) is also provided with a rotation driving mechanism (7) for driving the lower pressing plate (62) to rotate around the rotating shaft (64); when the lower pressing plate (62) rotates to the uppermost position, the upper surface of the arc-shaped groove II of the lower pressing plate (62) and the bottom of the arc-shaped groove I of the upper limit plate (61) are mutually abutted; the clamping plate (63) is horizontally arranged on the inner side of the front side plate (41) and is located above the front end of the lower pressing plate (62); the clamping plate (63) is located on the front side of the upper limit plate (61); and the clamping plate (63) is provided with a drug mixing interface fixing clamping position (631) and an infusion interface clamping position (632); A drug mixing interface (51) and an infusion interface (52) are provided at one end of the bag body of the low molecular weight heparin drug solution bag (5), and a one-way valve (53) is provided on the infusion interface (52); the low molecular weight heparin drug solution bag (5) is placed in the arc groove II of the lower pressure plate (62), the drug mixing interface (51) is clamped in the drug mixing interface fixed clamping position (631), the infusion interface (52) is clamped in the infusion interface clamping position (632), the end of the infusion interface (52) is clamped in the liquid inlet (11), and the outer wall of the end of the infusion interface (52) is sealed and matched with the inner wall of the liquid inlet (11).

2. The low molecular weight heparin liquid pre-filled integrated hemodialysis syringe according to claim 1, characterized in that: The rotation drive mechanism (7) includes a pull rod (71), a pull rope I (72) and a pull rope II (73); the pull rod (71) is arranged below the bottom of the injection syringe (1), the axis of the pull rod (71) is parallel to the axis of the injection syringe (1), the front end of the pull rod (71) passes through the rear side plate (44) and extends into the sealing box (4), the pull rod (71) and the rear side plate (44) slide and seal in the front-to-back direction, the front end of the pull rod (71) extends to the upper rear end of the upper limit plate (61), one end of the pull rope I (72) is connected to the rear end of the lower pressure plate (62), and the other end of the pull rope I (72) is connected to the front end of the pull rod (71); one end of the pull rope II (73) is connected to the rear end of the pull rod (71), and the other end of the pull rope II (73) is detachably connected to the rear end of the piston (2).

3. The low molecular weight heparin liquid pre-filled integrated hemodialysis syringe according to claim 2, characterized in that: The rotation drive mechanism (7) further comprises a guide sleeve (74), wherein the guide sleeve (74) is arranged below the bottom of the injection syringe (1) and between the rear side plate (44) and the rear end of the injection syringe (1), wherein the axis of the guide sleeve (74) is parallel to the axis of the injection syringe (1), and the pull rod (71) passes through the guide sleeve (74) and is slidably engaged with the guide sleeve (74).

4. The low molecular weight heparin liquid pre-filled integrated hemodialysis syringe according to claim 3, characterized in that: A filter membrane (54) is arranged near the inner side of the infusion interface (52).

5. The low molecular weight heparin liquid pre-filled integrated hemodialysis syringe according to claim 4, characterized in that: A limit block (75) is provided at the rear end of the pull rod (71) to prevent the rear end of the pull rod (71) from sliding into the guide sleeve (74), and the lateral dimension of the limit block (75) is greater than the inner diameter of the guide sleeve (74).

6. The low molecular weight heparin liquid pre-filled integrated hemodialysis syringe according to claim 5, characterized in that: A through hole I is provided at the rear end of the upper limit plate (61) in the vertical direction, and the pull rope I (72) passes through the through hole I.

7. The low molecular weight heparin liquid pre-filled integrated hemodialysis syringe according to claim 6, characterized in that: The sealed box (4) is a transparent sterile sealed box.

8. The low molecular weight heparin liquid pre-filled integrated hemodialysis syringe according to any one of claims 1 to 7, characterized in that: The empty needle nipple (3) is provided with a connecting sealing sleeve (8) outside, and an internal thread (81) that cooperates with the external thread on the catheter connector (9) is provided on the inner wall of the connecting sealing sleeve (8) near the rear side, the rear end of the connecting sealing sleeve (8) is rotatably and sealingly connected to the rear end of the empty needle nipple (3), and a sealing membrane (82) is provided at the front end of the connecting sealing sleeve (8).

9. The low molecular weight heparin liquid pre-filled integrated hemodialysis syringe according to claim 8, characterized in that: A sterilizing cotton sleeve (83) is arranged on the inner wall of the connecting sealing sleeve (8) near the front side, and the outer wall of the sterilizing cotton sleeve (83) is in close contact with the inner wall of the connecting sealing sleeve (8).

10. The low molecular weight heparin liquid pre-filled integrated hemodialysis syringe according to claim 9, characterized in that: The connecting sealing sleeve (8) is composed of two semicircular sleeves, one side of the two semicircular sleeves is rotatably sealed and connected, and the other side of the two semicircular sleeves is sealed and connected via mutually buckled connecting belts (84).

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