Eye drops manufacturing method and manufacturing equipment

Abstract

The invention provides an eye drop manufacturing method and manufacturing equipment, which belongs to the technical field of eye drops and aims to solve the problem that the current preparation efficiency of eye drops is low and the manufacturing process of the preparation equipment has not been automated. The invention comprises: a shell, wherein a first cavity, a second cavity, a third cavity and a fourth cavity are arranged in the shell; a heating wire is arranged in the first cavity; a solution extraction mechanism; a funnel; a stirring mechanism, wherein the stirring mechanism is arranged at the bottom of the first cylinder; an ultrasonic device, wherein the ultrasonic device comprises a transducer and an ultrasonic generator arranged in the first cylinder; a liquid leakage valve is arranged at the bottom of the first cylinder, and the bottom of the liquid leakage valve is connected to the third cavity; a filtrate mechanism; a cooling device for cooling the third cavity; a first vacuum pump is connected to the third cavity; a reflux pump and a first solenoid valve, wherein the reflux pump is connected to the third cavity, one end of the first solenoid valve is connected to the third cavity, and the other end of the first solenoid valve is connected to the stirring cavity; and a second vacuum pump is connected to the inside of the stirring cavity.

Description

Technical Field

[0001] The present invention belongs to the technical field of eye drops, and more specifically, particularly relates to an eye drop manufacturing method and manufacturing equipment thereof. Background Art

[0002] Eye drops refer to liquid medicines for instillation into the eye. Cyclosporine is a cyclic polypeptide composed of 11 amino acids and is an immunosuppressant. It is extracted from the metabolites of fungi. In addition to cyclosporine, eye drops also contain some auxiliary ingredients such as solubilizers (such as polysorbate 80), isotonic regulators (such as sodium chloride), pH regulators (such as phosphate buffer) and possible preservatives (such as benzalkonium chloride). The quality of these excipients must also meet pharmaceutical standards and be accurately weighed to ensure that they can play their due role in the preparation. Cyclosporine eye drops exist in liquid form and directly act on the eyes by eye drops to play its role in treating eye diseases.

[0003] The preparation of the eye drop stock solution comprises the following steps:

[0004] 1. Raw material preparation

[0005] Main drug: First, high-quality cyclosporine raw materials must be prepared. Cyclosporine is usually extracted from fungal metabolites, and its purity needs to meet certain standards. Because the purity of the drug directly affects the quality and safety of the product, insufficient purity may introduce impurities and increase the risk of adverse reactions.

[0006] Excipients: Various excipients should be prepared at the same time, such as solubilizers (such as polysorbate 80), isotonic regulators (such as sodium chloride), pH regulators (such as phosphate buffer) and possible preservatives (such as benzalkonium chloride). The quality of these excipients must also meet pharmaceutical standards and must be accurately weighed to ensure that they can play their due role in the preparation.

[0007] 2. Dissolution and preparation

[0008] Dissolve cyclosporine in an appropriate solvent. This process may require the use of a solubilizer to help cyclosporine fully dissolve. For example, in the presence of polysorbate 80, cyclosporine is evenly dispersed in a solution containing a solubilizer by stirring to form a preliminary drug solution.

[0009] Next, an isotonicity regulator is added to adjust the osmotic pressure of the solution to make it close to the osmotic pressure of human tears. This step usually requires precise control of the amount of sodium chloride and other substances added, which can generally be detected and adjusted by equipment such as an osmotic pressure meter.

[0010] Then, a pH adjuster is used to adjust the pH value of the solution. The physiological pH value of the eye is generally around 7.0-7.4, so the pH value of the drug solution should be adjusted to this appropriate range to reduce irritation to the eye while ensuring the stability of the drug.

[0011] 3. Filtration and sterilization

[0012] After the above preparation, in order to remove the particles and microorganisms in the solution, filtration and sterilization are required. Generally, microporous filter membranes are used for filtration, and the pore size of the filter membrane is usually 0.22μm or 0.45μm. This filtration method can effectively remove microorganisms such as bacteria and fungi, as well as some insoluble impurity particles, to ensure the sterility and purity of the eye drops.

[0013] However, the current preparation of cyclosporine eye drops has the following problems:

[0014] The current process for preparing eye drops is inefficient. In order to improve the preparation efficiency, a new preparation process needs to be designed.

[0015] Moreover, the equipment in the prior art is manually operated during the preparation process, which not only further reduces the preparation efficiency, but also cannot be automated, requiring a large amount of labor to be wasted.

[0016] Therefore, in view of this, the existing structure and defects are studied and improved, and a method for manufacturing eye drops and a manufacturing device thereof are provided, in order to achieve a more practical purpose. Summary of the invention

[0017] In order to solve the above technical problems, the present invention provides an eye drop manufacturing method and a manufacturing device thereof, so as to solve the problem that the preparation process scheme of the present invention is low in efficiency; the equipment in the prior art is manually operated during the preparation process, which further reduces the preparation efficiency and cannot be automated, requiring a large amount of labor to be wasted.

[0018] The purpose and effect of the eye drops manufacturing method and manufacturing equipment of the present invention are achieved by the following specific technical means:

[0019] A method for preparing eye drops, comprising the following steps:

[0020] Step 1: prepare m grams of cyclosporine and v milliliters of organic solvent, 0.05% ≤ m / v ≤ 0.1%;

[0021] Step 2: pouring cyclosporine into an organic solvent to dissolve it, thereby obtaining a cyclosporine solvent;

[0022] Step 3: The organic solvent is evaporated by rotating vacuum in a 40°C water bath to form a uniform film inside the container;

[0023] Step 4: adding distilled water to fully wash the membrane, performing water bath ultrasound to obtain a micellar solution, filtering and freeze drying to obtain a dry powder preparation of cyclosporine;

[0024] Step 5: Re-disperse and dissolve in sterile buffer;

[0025] Step 6: Finally, add preservatives and pH adjusters;

[0026] Step 7: Sterile filtration after isotonicity adjuster.

[0027] An eye drop manufacturing device, comprising:

[0028] A shell, the shell comprising a first cylinder with an upper opening, a second cylinder arranged at the outer periphery of the first cylinder and penetrating from top to bottom, and a third cylinder arranged at the bottom of the first cylinder and opening at the upper portion, a first cavity is formed between the first cylinder and the second cylinder, a partition is arranged in the third cylinder, and the partition divides the third cylinder into a second cavity, a third cavity, and a fourth cavity;

[0029] A heating wire is arranged in the first cavity;

[0030] A solution extraction mechanism, wherein the solution extraction mechanism is provided with a container, wherein a plurality of solution cavities are provided in the container, and the solution extraction mechanism can extract various solutions in the solution cavities and discharge them into the first cylinder;

[0031] A funnel, wherein the funnel is disposed at the lower part of the solution extraction mechanism, the funnel is fixedly connected to the inner peripheral wall of the first cylinder, the lower part of the funnel is connected to a second solenoid valve, and the funnel and the bottom of the first cylinder form a stirring chamber;

[0032] A stirring mechanism, the stirring mechanism is arranged at the bottom of the first cylinder, and the stirring mechanism is used to stir the solution in the stirring chamber;

[0033] An ultrasonic device, comprising a transducer and an ultrasonic generator, wherein the transducer is disposed in the first cylinder;

[0034] A liquid leakage valve, wherein the bottom of the first cylinder is provided with a liquid leakage valve, and the bottom of the liquid leakage valve is connected with the third cavity;

[0035] A filtrate mechanism, wherein the filtrate mechanism is provided with a vertical flow channel, a funnel is provided in the flow channel, and a filter membrane is provided in the funnel;

[0036] A cooling device, the cooling device is used to cool the third cavity;

[0037] a first vacuum pump, the first vacuum pump being in communication with the third cavity;

[0038] A reflux pump and a first solenoid valve, wherein the reflux pump is connected to the third cavity, one end of the first solenoid valve is connected to the third cavity, and the other end of the first solenoid valve is connected to the stirring cavity;

[0039] A second vacuum pump is communicated with the interior of the stirring chamber.

[0040] Furthermore, the solution extraction mechanism includes a transverse movement mechanism and a longitudinal movement mechanism;

[0041] The transverse movement mechanism comprises a first motor fixedly connected to the container, a first lead screw transmission-connected to the first motor, a first lead screw nut threadedly connected to the first lead screw, and a first guide shaft fixedly connected to the container, wherein the first lead screw nut is slidably connected to the first guide shaft, and the first lead screw is parallel to the first guide shaft;

[0042] The longitudinal movement mechanism includes a second motor fixedly connected to the first lead screw nut, a second guide shaft slidably connected to the first lead screw nut, a second lead screw transmission-connected to the second motor, a second lead screw nut threadedly connected to the second lead screw, a side plate fixedly connected to the second lead screw nut, and an extension plate fixedly connected to the side plate, the second lead screw is parallel to the second guide shaft, and the first lead screw and the second lead screw are perpendicular to each other.

[0043] Furthermore, it also includes an electric telescopic rod fixedly connected to the container, and a syringe drivingly connected to the electric telescopic rod, wherein the syringe includes an empty cylinder fixedly connected to the container, a piston movably arranged on the inner wall of the empty cylinder, and a piston shaft connected to the piston at one end, wherein the piston shaft is connected to the driving end of the electric telescopic rod;

[0044] The empty cylinder is provided with a nipple, the nipple is connected to one end of the catheter, the other end of the catheter is connected to the needle, and the needle is fixedly connected to the extension plate.

[0045] Furthermore, each of the solution chambers is provided with an opening, and the opening is provided with a rubber stopper.

[0046] Furthermore, the stirring mechanism includes a third motor fixedly connected to the inner wall of the second cavity, a driving ring drivingly connected to the third motor, and an inner driven ring arranged in the driving ring, wherein the inner driven ring is arranged at the bottom of the first cylinder;

[0047] A plurality of inner magnets are arranged on the outer periphery of the inner driven ring, a plurality of stirring blades are arranged on the inner driven ring, an inner gear portion is arranged on the driving ring, a first gear is connected to the third motor transmission, the first gear is meshed with the inner gear portion, a plurality of outer magnets are arranged on the driving ring, and the inner magnets and the outer magnets can be connected by magnetic attraction.

[0048] Further, the leakage valve is provided with a vertical tube, a ring-shaped raised portion is provided in the middle of the vertical tube, a first cross bar is fixedly connected to the inner wall of the raised portion, the first cross bar is vertically slidably connected to the vertical rod, a plug is fixedly connected to the upper part of the vertical rod, a set is fixedly connected to the vertical tube, the set is laterally slidably connected to the second cross bar, the second cross bar is provided with a rack portion, a fourth motor is fixedly connected to the inner wall of the second cavity, the fourth motor is transmission-connected to the second gear, and the second gear is meshed with the rack portion;

[0049] The vertical rod is provided with a first inclined plane, and the second cross rod is provided with a second inclined plane. The first inclined plane and the second inclined plane are parallel and can contact each other.

[0050] Furthermore, the cooling device comprises an evaporator, a compressor, a condenser, a drying filter and a capillary tube which are connected end to end in sequence, and the evaporator is arranged in the fourth cavity.

[0051] Furthermore, it also includes a discharge piece, wherein the discharge piece is provided with a channel connecting the upper surface to the side surface.

[0052] Compared with the prior art, the present invention has the following beneficial effects:

[0053] 1. The present invention improves the preparation efficiency by improving the process scheme.

[0054] 2. When the device of the present invention is used, a certain amount of cyclosporine solution and a certain amount of organic solution are first extracted by the solution extraction mechanism and injected into the funnel. Then the second solenoid valve is opened, and the liquid flows into the bottom of the first cylinder, and then stirred by the stirring mechanism. Then the electric heating wire heats the solution in the first cylinder to 40° C., and then the second solenoid valve is closed, and the second vacuum pump performs a vacuuming process on the stirring chamber. After the organic solvent evaporates and forms a uniform film inside the stirring chamber, the second solenoid valve is opened, and then a certain amount of distilled water is extracted by the solution extraction mechanism to fully wash the film. Then the ultrasonic device is started to obtain a micellar solution, and then the first vacuum pump is started, and the leakage valve is opened. The liquid is filtered through the filter membrane of the filtration mechanism and flows into the third cavity for freeze drying to obtain a dry powder preparation of cyclosporine. Then a certain amount of sterile buffer is extracted by the solution extraction mechanism to disperse and dissolve the dry powder preparation, and then the liquid in the third cavity is returned to the stirring chamber. Finally, after adding a preservative, a pH adjuster and an isotonic adjuster, the original filtration mechanism is replaced with a discharge piece to lead out the liquid, and finally aseptic filtration is performed. BRIEF DESCRIPTION OF THE DRAWINGS

[0055] Figure 1 The present invention is a three-dimensional structural schematic diagram of an eye drop manufacturing method and a manufacturing device thereof.

[0056] Figure 2The invention discloses a cross-sectional structural schematic diagram of an eye drop manufacturing method and a manufacturing device thereof.

[0057] Figure 3 The invention discloses an exploded structural diagram of an eye drop manufacturing method and a manufacturing device thereof.

[0058] Figure 4 The present invention is a three-dimensional structural schematic diagram of a method for manufacturing eye drops and a cooling device of a manufacturing device thereof.

[0059] Figure 5 The invention discloses a cross-sectional structural schematic diagram of a method for manufacturing eye drops and a filtrate mechanism of a manufacturing device thereof.

[0060] Figure 6 The present invention is a three-dimensional structural schematic diagram of a solution extraction mechanism of an eye drop manufacturing method and a manufacturing device thereof.

[0061] Figure 7 The present invention Figure 6 Enlarged structural diagram at A in the middle.

[0062] Figure 8 The invention discloses an exploded structural diagram of a stirring mechanism of an eye drop manufacturing method and a manufacturing device thereof.

[0063] Fig. 9 The present invention is a schematic cross-sectional structure diagram of a solution extraction mechanism of an eye drop manufacturing method and a manufacturing device thereof.

[0064] Fig.10 The invention discloses a cross-sectional structural schematic diagram of a leakage valve of an eye drop manufacturing method and a manufacturing device thereof.

[0065] Fig.11 The invention discloses a cross-sectional structural schematic diagram of a syringe in a method for manufacturing eye drops and a manufacturing device thereof.

[0066] Fig.12 The invention discloses a cross-sectional structural schematic diagram of a method for manufacturing eye drops and a discharge piece of a manufacturing device thereof.

[0067] In the figure, the corresponding relationship between the component names and the figure numbers is as follows:

[0068] Shell 1, first cylinder 11, second cylinder 12, first cavity 120, electric heating wire 121, third cylinder 13, second cavity 130, third cavity 131, fourth cavity 132, solution extraction mechanism 2, container 20, solution cavity 21, opening 22, rubber stopper 220, electric telescopic rod 23, syringe 24, empty cylinder 241, piston 242, piston shaft 243, nipple 2410, catheter 25, needle 26, transverse mechanism 27, first motor 271, first lead screw 272, first lead screw nut 273, first guide shaft 274, longitudinal mechanism 28, second motor 284, second guide shaft 283, second lead screw 282, second lead screw nut 281, side plate 280, extension plate 285, funnel 3, second solenoid valve 30, Stirring mechanism 4, third motor 41, drive ring 42, inner gear portion 421, outer magnet 422, inner magnet 431 of inner driven ring 43, stirring blade 432, first gear 44, ultrasonic device 5, transducer 50, ultrasonic generator 51, leakage valve 6, vertical tube 61, raised portion 62, first cross bar 63, vertical rod 64, plug 65, kit 66, second cross bar 67, rack portion 670, second gear 68, fourth motor 69, filtrate mechanism 7, flow channel 70, funnel portion 71, filter membrane 72, cooling device 8, evaporator 80, compressor 81, condenser 82, drying filter 83, capillary 84, first vacuum pump 90, reflux pump 91, first solenoid valve 92, second vacuum pump 93, discharge piece 94, channel 940. DETAILED DESCRIPTION

[0069] The following embodiments of the present invention are described in further detail in conjunction with the accompanying drawings and examples. The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention.

[0070] In the description of the present invention, unless otherwise specified, "plurality" means two or more than two; the orientations or positional relationships indicated by the terms "upper", "lower", "left", "right", "inner", "outer", "front end", "rear end", "head", "tail", etc. are based on the orientations or positional relationships shown in the drawings, and are only for the convenience of describing the present invention and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operate in a specific orientation, and therefore cannot be understood as limiting the present invention. In addition, the terms "first", "second", "third", etc. are only used for descriptive purposes and cannot be understood as indicating or implying relative importance.

[0071] In the description of the present invention, it should be noted that, unless otherwise clearly specified and limited, the terms "connected" and "connection" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0072] Embodiment 1:

[0073] The present invention provides a method for preparing eye drops, comprising the following steps:

[0074] Step 1: prepare m grams of cyclosporine and v milliliters of organic solvent, 0.05% ≤ m / v ≤ 0.1%;

[0075] Step 2: pouring cyclosporine into an organic solvent to dissolve it, thereby obtaining a cyclosporine solvent;

[0076] Step 3: The organic solvent is evaporated by rotating vacuum in a 40°C water bath to form a uniform film inside the container;

[0077] Step 4: adding distilled water to fully wash the membrane, performing water bath ultrasound to obtain a micellar solution, filtering and freeze drying to obtain a dry powder preparation of cyclosporine;

[0078] Step 5: Re-disperse and dissolve in sterile buffer;

[0079] Step 6: Finally, add preservatives and pH adjusters;

[0080] Step 7: Sterile filtration after isotonicity adjuster.

[0081] The invention improves the preparation efficiency by improving the process scheme.

[0082] Embodiment 2:

[0083] As attached Figure 1 To Attachment Fig.12 As shown:

[0084] An eye drop manufacturing device, comprising:

[0085] The housing 1 comprises a first cylinder 11 with an upper opening, a second cylinder 12 disposed on the outer periphery of the first cylinder 11 and penetrating from top to bottom, and a third cylinder 13 disposed at the bottom of the first cylinder 11 and with an upper opening, wherein a first cavity 120 is formed between the first cylinder 11 and the second cylinder 12, and a partition is disposed in the third cylinder 13, and the partition divides the third cylinder 13 into a second cavity 130, a third cavity 131 and a fourth cavity 132;

[0086] A heating wire 121 is disposed in the first cavity 120, and the heating wire 121 is used to heat the internal space of the first cavity 120;

[0087] The solution extraction mechanism 2 is provided with a container 20, and a plurality of solution chambers 21 are provided in the container 20. The solution extraction mechanism 2 can extract various solutions in the solution chambers 21 and discharge them into the first barrel 11. Various liquids for making eye drops are poured into the plurality of solution chambers 21, and corresponding liquids are extracted from the solution extraction mechanism 2 in sequence and injected into the first barrel 11 for stirring and mixing, thereby realizing automatic liquid addition;

[0088] The funnel 3 is arranged at the lower part of the solution extraction mechanism 2, the funnel 3 is fixedly connected to the inner peripheral wall of the first cylinder 11, the lower part of the funnel 3 is connected to the second solenoid valve 30, and the funnel 3 and the bottom of the first cylinder 11 form a stirring chamber;

[0089] A stirring mechanism 4, which is disposed at the bottom of the first cylinder 11 and is used to stir the solution in the stirring chamber;

[0090] The ultrasonic device 5 includes a transducer 50 and an ultrasonic generator 51, and the transducer 50 is disposed in the first cylinder 11;

[0091] A liquid leakage valve 6 is provided at the bottom of the first cylinder 11, and the bottom of the liquid leakage valve 6 is communicated with the third cavity 131;

[0092] The filtrate mechanism 7 is provided with a vertical flow channel 70, a funnel portion 71 is provided in the flow channel 70, and a filter membrane 72 is provided in the funnel portion 71, so that the liquid flowing through the leakage valve 6 is filtered through the filter membrane 72;

[0093] A cooling device 8, the cooling device 8 is used to cool the third cavity 131;

[0094] A first vacuum pump 90, the first vacuum pump 90 is connected to the third cavity 131;

[0095] A reflux pump 91 and a first solenoid valve 92, wherein the reflux pump 91 is connected to the third cavity 131, one end of the first solenoid valve 92 is connected to the third cavity 131, and the other end of the first solenoid valve 92 is connected to the stirring cavity;

[0096] The second vacuum pump 93 is communicated with the interior of the stirring chamber.

[0097] When the device in this embodiment is used, a certain amount of cyclosporine solution and a certain amount of organic solution are first extracted by the solution extraction mechanism and injected into the funnel 3, then the second solenoid valve 30 is opened, the liquid flows into the bottom of the first cylinder 11, and then stirred by the stirring mechanism 4, then the electric heating wire 121 heats the solution in the first cylinder 11 to 40°C, then the second solenoid valve 30 is closed, and the second vacuum pump 93 performs a vacuuming process on the stirring chamber, and when the organic solvent evaporates and forms a uniform film inside the stirring chamber, the second solenoid valve 30 is opened, and then a certain amount of vapor is extracted by the solution extraction mechanism. Distilled water is used to fully wash the membrane, and then the ultrasonic device 5 is started to obtain a micellar solution. The first vacuum pump 90 is then started, and the leakage valve 6 is opened. The liquid is filtered through the filter membrane 72 of the filter liquid mechanism 7 and flows into the third cavity 131 to be freeze-dried to obtain a dry powder preparation of cyclosporine. A certain amount of sterile buffer is then extracted through the solution extraction mechanism to disperse and dissolve the dry powder preparation. The liquid in the third cavity 131 is then returned to the stirring chamber. Finally, after adding a preservative, a pH adjuster, and an isotonic adjuster, the original filter liquid mechanism 7 is replaced with a discharge piece 94 to draw out the liquid, and finally aseptic filtration is performed.

[0098] The solution extraction mechanism 2 includes a transverse movement mechanism 27 and a longitudinal movement mechanism 28;

[0099] The transverse movement mechanism 27 includes a first motor 271 fixedly connected to the container 20, a first lead screw 272 drivingly connected to the first motor 271, a first lead screw nut 273 threadedly connected to the first lead screw 272, and a first guide shaft 274 fixedly connected to the container 20, the first lead screw nut 273 is slidably connected to the first guide shaft 274, and the first lead screw 272 is parallel to the first guide shaft 274;

[0100] The longitudinal movement mechanism 28 includes a second motor 284 fixedly connected to the first lead screw nut 273, a second guide shaft 283 slidingly connected to the first lead screw nut 273, a second lead screw 282 transmission-connected to the second motor 284, a second lead screw nut 281 threadedly connected to the second lead screw 282, a side plate 280 fixedly connected to the second lead screw nut 281, and an extension plate 285 fixedly connected to the side plate 280. The second lead screw 282 is parallel to the second guide shaft 283, and the first lead screw 272 and the second lead screw 282 are perpendicular to each other.

[0101] It also includes an electric telescopic rod 23 fixedly connected to the container 20, and a syringe 24 drivingly connected to the electric telescopic rod 23. The syringe 24 includes an empty cylinder 241 fixedly connected to the container 20, a piston 242 movably arranged on the inner wall of the empty cylinder 241, and a piston shaft 243 connected to the piston 242 at one end. The piston shaft 243 is connected to the driving end of the electric telescopic rod 23;

[0102] The hollow cylinder 241 is provided with a nipple 2410 , which is connected to one end of the catheter 25 , and the other end of the catheter 25 is connected to the needle 26 , and the needle 26 is fixedly connected to the extension plate 285 .

[0103] The solution chamber 21 is provided with an opening 22, and the opening 22 is provided with a rubber plug 220. The provision of the rubber plug 220 allows the opening 22 to be sealed while facilitating the insertion of the needle 26.

[0104] The stirring mechanism 4 includes a third motor 41 fixedly connected to the inner wall of the second cavity 130, a driving ring 42 drivingly connected to the third motor 41, and an inner driven ring 43 arranged in the driving ring 42, and the inner driven ring 43 is arranged at the bottom of the first cylinder 11;

[0105] A plurality of inner magnets 431 are arranged on the outer periphery of the inner driven ring 43, a plurality of stirring blades 432 are arranged on the inner driven ring 43, an inner gear portion 421 is arranged on the driving ring 42, a first gear 44 is drivingly connected to the third motor 41, the first gear 44 is meshed with the inner gear portion 421, a plurality of outer magnets 422 are arranged on the driving ring 42, and the inner magnets 431 and the outer magnets 422 can be magnetically connected. By arranging a magnetic structure, the bottom of the first cylinder (11) can be absolutely sealed while transmitting stirring power, which has great advantages for preparations that require a vacuum environment for preparation, and greatly reduces the probability of equipment failure.

[0106] The liquid leakage valve 6 is provided with a vertical tube 61, a ring-shaped raised portion 62 is provided in the middle of the vertical tube 61, a first cross bar 63 is fixedly connected to the inner wall of the raised portion 62, the first cross bar 63 is vertically slidably connected to the vertical rod 64, a plug 65 is fixedly connected to the upper part of the vertical rod 64, a set 66 is fixedly connected to the vertical tube 61, the set 66 is laterally slidably connected to the second cross bar 67, the second cross bar 67 is provided with a rack portion 670, a fourth motor 69 is fixedly connected to the inner wall of the second cavity 130, the fourth motor 69 is transmission-connected to the second gear 68, and the second gear 68 is meshed with the rack portion 670;

[0107] The vertical rod 64 is provided with a first inclined plane, and the second crossbar 67 is provided with a second inclined plane, and the first inclined plane and the second inclined plane are parallel and can contact each other. The inclined planes corresponding to the vertical rod 64 and the second crossbar 67 are both 45 degrees, so that the second crossbar 67 can push the vertical rod 64 while moving. When the second crossbar 67 moves outward under the action of the fourth motor 69, and the first inclined plane and the second inclined plane are always in contact, the plug 65 moves downward under the action of gravity, so that the liquid flows downward; when the second crossbar 67 moves inward under the action of the fourth motor 69, the second crossbar 67 applies an upward component force to the vertical rod 64, so that the plug 65 is pushed back to the upper end of the vertical tube 61 for sealing.

[0108] The cooling device 8 comprises an evaporator 80, a compressor 81, a condenser 82, a drying filter 83 and a capillary tube 84 connected end to end in sequence, and the evaporator 80 is arranged in the fourth cavity 132. The basic principle of the cooling device 8 is the same as the refrigeration principle of a refrigerator, and the evaporator 80 absorbs the third cavity 131.

[0109] It also includes a discharge piece 94, which is provided with a channel 940 connecting the upper surface to the side surface.

[0110] When the solution is implemented, a control chip needs to be provided to control the operation of each electronic component to realize its function.

[0111] The embodiments of the present invention are given for the purpose of illustration and description, and are not intended to be exhaustive or to limit the invention to the disclosed forms. Many modifications and variations will be apparent to those of ordinary skill in the art. The embodiments are selected and described in order to better illustrate the principles and practical applications of the present invention and to enable those of ordinary skill in the art to understand the present invention and thereby design various embodiments with various modifications suitable for specific uses.

Claims

1. A method for producing eye drops, characterized in that: The following steps are involved: Step 1: prepare m grams of cyclosporine and v milliliters of organic solvent, 0.05% ≤ m / v ≤ 0.1%; Step 2: pouring cyclosporine into an organic solvent to dissolve it, thereby obtaining a cyclosporine solvent; Step 3: The organic solvent is evaporated by rotating vacuum in a 40°C water bath to form a uniform film inside the container; Step 4: adding distilled water to fully wash the membrane, performing water bath ultrasound to obtain a micellar solution, filtering and freeze drying to obtain a dry powder preparation of cyclosporine; Step 5: Re-disperse and dissolve in sterile buffer; Step 6: Finally, add preservatives and pH adjusters; Step 7: Sterile filtration after isotonicity adjuster.

2. An eye drop manufacturing device, characterized in that: include: A shell (1), the shell (1) comprising a first cylinder (11) with an opening at the top, a second cylinder (12) arranged at the outer periphery of the first cylinder (11) and penetrating from top to bottom, and a third cylinder (13) arranged at the bottom of the first cylinder (11) and with an opening at the top, a first cavity (120) being formed between the first cylinder (11) and the second cylinder (12), a partition being arranged in the third cylinder (13), and the partition dividing the third cylinder (13) into a second cavity (130), a third cavity (131) and a fourth cavity (132); A heating wire (121) is arranged in the first cavity (120); A solution extraction mechanism (2), wherein the solution extraction mechanism (2) is provided with a container (20), wherein a plurality of solution chambers (21) are provided in the container (20), and the solution extraction mechanism (2) is capable of extracting various solutions in the solution chambers (21) and discharging them into the first barrel (11); A funnel (3), the funnel (3) being arranged at the lower part of the solution extraction mechanism (2), the funnel (3) being fixedly connected to the inner peripheral wall of the first cylinder (11), the lower part of the funnel (3) being connected to a second solenoid valve (30), and the funnel (3) and the bottom of the first cylinder (11) forming a stirring chamber; A stirring mechanism (4), wherein the stirring mechanism (4) is arranged at the bottom of the first cylinder (11), and the stirring mechanism (4) is used to stir the solution in the stirring chamber; An ultrasonic device (5), the ultrasonic device (5) comprising a transducer (50) and an ultrasonic generator (51), the transducer (50) being arranged in the first cylinder (11); A liquid leakage valve (6), wherein the bottom of the first cylinder (11) is provided with a liquid leakage valve (6), and the bottom of the liquid leakage valve (6) is connected to the third cavity (131); A filtrate mechanism (7), wherein the filtrate mechanism (7) is provided with a vertical flow channel (70), a funnel portion (71) is provided in the flow channel (70), and a filter membrane (72) is provided in the funnel portion (71); A cooling device (8), wherein the cooling device (8) is used to cool the third cavity (131); a first vacuum pump (90), the first vacuum pump (90) being in communication with the third chamber (131); a reflux pump (91) and a first solenoid valve (92), wherein the reflux pump (91) is in communication with the third cavity (131), one end of the first solenoid valve (92) is in communication with the third cavity (131), and the other end of the first solenoid valve (92) is in communication with the stirring cavity; A second vacuum pump (93), the second vacuum pump (93) is communicated with the interior of the stirring chamber.

3. An eye drop manufacturing device as claimed in claim 2, characterized in that: The solution extraction mechanism (2) comprises a transverse movement mechanism (27) and a longitudinal movement mechanism (28); The transverse movement mechanism (27) comprises a first motor (271) fixedly connected to the container (20), a first lead screw (272) drivingly connected to the first motor (271), a first lead screw nut (273) threadedly connected to the first lead screw (272), and a first guide shaft (274) fixedly connected to the container (20), the first lead screw nut (273) being slidably connected to the first guide shaft (274), and the first lead screw (272) and the first guide shaft (274) being parallel; The longitudinal movement mechanism (28) comprises a second motor (284) fixedly connected to the first lead screw nut (273), a second guide shaft (283) slidably connected to the first lead screw nut (273), a second lead screw (282) transmission-connected to the second motor (284), a second lead screw nut (281) threadedly connected to the second lead screw (282), a side plate (280) fixedly connected to the second lead screw nut (281), and an extension plate (285) fixedly connected to the side plate (280), wherein the second lead screw (282) is parallel to the second guide shaft (283), and the first lead screw (272) and the second lead screw (282) are perpendicular to each other.

4. An eye drop manufacturing device as claimed in claim 3, characterized in that: It also comprises an electric telescopic rod (23) fixedly connected to the container (20), and a syringe (24) drivingly connected to the electric telescopic rod (23), wherein the syringe (24) comprises an empty cylinder (241) fixedly connected to the container (20), a piston (242) movably arranged on the inner wall of the empty cylinder (241), and a piston shaft (243) connected to the piston (242) at one end, wherein the piston shaft (243) is connected to the driving end of the electric telescopic rod (23); The hollow cylinder (241) is provided with a nipple (2410), the nipple (2410) is connected to one end of the catheter (25), the other end of the catheter (25) is connected to the needle (26), and the needle (26) is fixedly connected to the extension plate (285).

5. An eye drop manufacturing device as claimed in claim 2, characterized in that: The solution chambers (21) are each provided with an opening (22), and the opening (22) is provided with a rubber stopper (220).

6. An eye drop manufacturing device as claimed in claim 2, characterized in that: The stirring mechanism (4) comprises a third motor (41) fixedly connected to the inner wall of the second cavity (130), a driving ring (42) drivingly connected to the third motor (41), and an inner driven ring (43) arranged in the driving ring (42), wherein the inner driven ring (43) is arranged at the bottom of the first cylinder (11); A plurality of inner magnets (431) are arranged on the outer periphery of the inner driven ring (43), a plurality of stirring blades (432) are arranged on the inner driven ring (43), the driving ring (42) is provided with an inner gear portion (421), the third motor (41) is transmission-connected with a first gear (44), the first gear (44) is meshed with the inner gear portion (421), the driving ring (42) is provided with a plurality of outer magnets (422), and the inner magnets (431) and the outer magnets (422) can be magnetically connected.

7. An eye drop manufacturing device as claimed in claim 2, characterized in that: The liquid leakage valve (6) is provided with a vertical tube (61), a ring-shaped raised portion (62) is provided in the middle of the vertical tube (61), a first cross bar (63) is fixedly connected to the inner wall of the raised portion (62), the first cross bar (63) is vertically slidably connected to the vertical rod (64), a plug (65) is fixedly connected to the upper part of the vertical rod (64), the vertical tube (61) is fixedly connected to a sleeve (66), the sleeve (66) is laterally slidably connected to the second cross bar (67), the second cross bar (67) is provided with a rack portion (670), the inner wall of the second cavity (130) is fixedly connected to a fourth motor (69), the fourth motor (69) is transmission-connected to a second gear (68), and the second gear (68) is meshed with the rack portion (670); The vertical rod (64) is provided with a first inclined surface, and the second cross rod (67) is provided with a second inclined surface. The first inclined surface and the second inclined surface are parallel and can contact each other.

8. An eye drop manufacturing device according to any one of claims 2 to 7, characterized in that: The cooling device (8) comprises an evaporator (80), a compressor (81), a condenser (82), a drying filter (83) and a capillary tube (84) which are connected end to end in sequence, and the evaporator (80) is arranged in the fourth cavity (132).

9. An eye drop manufacturing device as claimed in claim 8, characterized in that: The device also includes a discharge piece (94) having a channel (940) connecting an upper surface to a side surface.

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