Blood component collection and separation device and use method thereof

Abstract

The invention discloses a blood component collection and separation device and a use method thereof, relates to the technical field of blood separation, and aims to solve the problems of blood loss, blood volume reduction and leucocyte reduction easily occurring in blood donation. The multi-path box is connected with the needle head assembly, the separation assembly, the air bag, the blood sampling bag and the anticoagulant puncture outfit through pipelines, and the saline puncture outfit is connected with a filter and is connected with the multi-path box through a saline pipeline, so that in-vitro residual blood and human body leucocyte loss after blood donation are reduced, and reduction of the blood volume in a human body is avoided.

Description

Technical Field

[0001] The present invention relates to the technical field of blood separation, and more specifically, to a blood component collection and separation device and a method of using the same. Background Art

[0002] Platelets can be used to treat patients with thrombocytopenia or abnormal platelet function due to various reasons, which are common in surgical patients, leukemia, aplastic anemia, blood disease patients undergoing hematopoietic stem cell transplantation, and various cancer patients. In blood collection and supply institutions such as blood stations, blood from blood donors is collected, centrifuged, and separated with the help of blood cell separators and supporting consumables. Platelet products are collected and other blood components are returned to the blood donors. After the collection is completed, the blood remaining in the consumables is returned to the human body, and then the stored plasma is used for flushing and transfusion to reduce the loss of blood cells.

[0003] However, the existing technology has the following problems: First, the residual blood outside the body is not fully returned, a lot of blood is lost, and multiple blood donations affect human health; second, the problem of reduced blood volume in the human body. Each unit of collected platelets is 250mL. When collecting double platelets, more blood is lost, and the equipment cannot return all the blood remaining in the consumables to the human body. The inability to return the residual blood components will lead to a decrease in blood volume in the human body, and then increase the probability of blood donation reactions. When the blood volume loss exceeds 15%, symptoms such as dizziness and syncope are very likely to occur; third, the white blood cells in the separation tower are concentrated in large numbers and cannot be effectively flushed back.

[0004] Therefore, how to solve the problem of blood loss, blood volume and leukopenia that is prone to occur during blood donation is an urgent problem to be solved by technical personnel in this field. Summary of the invention

[0005] In view of this, the purpose of the present invention is to provide a blood component collection and separation device, which can reduce residual blood in vitro, loss of human white blood cells and reduction of blood volume in the human body after blood donation, and ensure the health of blood donors.

[0006] Another object of the present invention is to provide a method for using the above-mentioned blood component collection and separation device, which reduces the loss of blood cells and white blood cells of blood donors and effectively replenishes human blood volume.

[0007] In order to achieve the above object, the present invention provides the following technical solutions:

[0008] A blood component collection and separation device, comprising:

[0009] Needle assembly;

[0010] A multi-channel box is connected to the needle assembly, the separation assembly, the air bag, the blood collection bag and the anticoagulant puncture device through pipelines;

[0011] A saline puncture device is connected to a filter and is connected to a multi-channel box through a saline pipeline.

[0012] Preferably, a saline branch is provided on the saline pipeline, and the saline branch is connected to the needle assembly.

[0013] Preferably, a first control component for controlling the on-off of the brine branch is provided on the brine branch.

[0014] Preferably, a second control component for controlling the on-off of the brine pipeline is provided on the brine pipeline, and the junction between the brine branch and the brine pipeline is located between the second control component and the filter.

[0015] Preferably, the first control member and the second control member are one of a stop clamp and a flow control valve, or the first control member and the second control member are one of a peristaltic pump and a control valve on a separator.

[0016] Preferably, the blood collection bag includes a platelet bag for storing platelets, the platelet bag is provided with at least one, at least one platelet bag is connected to the multi-channel box through a first pipeline, and the first pipeline is provided with a first stop clamp for controlling the opening and closing of the first pipeline.

[0017] Preferably, a second pipeline is provided on the saline pipeline, the second pipeline is connected to a plasma bag, and a second stop clamp for controlling the on-off of the second pipeline is provided on the second pipeline.

[0018] Preferably, the needle assembly is connected to a multi-interface connector, which is used to connect the blood collection tube line, the blood return tube line, the anticoagulant line and the saline line. The blood collection tube line, the blood return tube line and the anticoagulant line are all connected to the multi-channel box.

[0019] Preferably, a filter is provided on the anticoagulant pipeline.

[0020] Preferably, the needle assembly includes a blood collection needle, which is connected to one interface of the multi-interface connector via a three-way connector, and the other interface of the three-way connector is connected to a sampling tube of the sampling device. The sampling tube is provided with a third stop clamp for controlling the flow of blood in the sampling tube.

[0021] Preferably, the multichannel box is connected to the separation component through a blood transfusion blood bundle, the outer sheath of the blood transfusion blood bundle is provided with a protective net, and the blood transfusion blood bundle includes an inlet blood line for conveying blood to the separation component, an outlet blood line for conveying separated platelets to the multichannel box, an adjustment line for conveying separated plasma and red blood cells to the multichannel box, and a plasma line for conveying separated plasma to the multichannel box.

[0022] Preferably, the separation component includes a separation belt, a dam and a separation tower, the separation belt is arranged in the centrifuge, the dam is arranged in the separation belt, and the dam is connected to the blood outlet line, the adjustment line and the plasma line, and the separation tower is arranged in the blood outlet line.

[0023] A method for using a blood component collection and separation device, applied to the above-mentioned blood component collection and separation device, the method for using includes:

[0024] Insert the saline puncture device into the saline bag to connect the saline bag to the multichannel box;

[0025] When the blood sampling is completed, the second control component is opened to allow the physiological saline to enter the multi-channel box, flow through the separation belt, the separation tower, the adjustment pipeline, the plasma pipeline, and then flow into the human body.

[0026] Preferably, after opening the first control element, the method further comprises:

[0027] Turn on the centrifuge to shake the separation column.

[0028] Preferably, the process of inserting the saline puncture device into the physiological saline bag also includes:

[0029] Connect the saline bag and the needle assembly;

[0030] Open the first control component, and after the physiological saline reaches the multi-port connector, close the first control component to collect blood;

[0031] When blood sampling is suspended, the first control member is opened to allow physiological saline to enter the needle assembly through the multi-interface connector and flow into the human body.

[0032] The blood component collection and separation device provided by the present invention comprises a needle assembly, a multi-channel box, a separation assembly, an air bag, a blood collection bag, an anticoagulant puncture device and a saline puncture device. Specifically, the multi-channel box is connected to the needle assembly, the separation assembly, the air bag, the blood collection bag and the anticoagulant puncture device through a pipeline, and the anticoagulant and the multi-channel box are connected through the anticoagulant puncture device, so that the anticoagulant enters the pipeline after passing through the multi-channel box, thereby avoiding the phenomenon of blood coagulation during the blood collection process. Blood is collected through the needle assembly, and the blood flows into the multi-channel box through the pipeline. The multi-channel box transports the blood to the separation assembly through the pipeline for separation, thereby separating the components in the blood, and the separated blood components are transported to the multi-channel box, the blood collection bag and the human body through the pipeline.

[0033] The saline puncture device is connected to a filter and is connected to the multi-channel box through a saline pipeline. The physiological saline and the multi-channel box are connected through the saline puncture device and the saline pipeline. The filter is set to achieve the effect of sterilization and filtration. After the blood collection is completed, the physiological saline can enter the multi-channel box and the separation component through the saline pipeline, and the residual blood can be back-flushed into the multi-channel box and the separation component, so that the blood in the multi-channel box and the separation component is flushed back into the human body with the physiological saline, which can reduce the residual blood outside the body after blood donation, the loss of human white blood cells, and the reduction of blood volume in the human body, thereby ensuring the health of the blood donor. BRIEF DESCRIPTION OF THE DRAWINGS

[0034] In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings required for use in the embodiments or the description of the prior art will be briefly introduced below. Obviously, the drawings described below are only embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on the provided drawings without paying creative work.

[0035] Figure 1 This is a schematic diagram of the structure of the blood component collection and separation device provided by the present invention;

[0036] Figure 2 for Figure 1 A schematic structural diagram of another embodiment;

[0037] Figure 3 for Figure 1 A structural schematic diagram of another embodiment;

[0038] Figure 4 for Figure 1 A structural schematic diagram of another embodiment;

[0039] Figure 5 A partial enlarged view of the needle assembly provided by the present invention;

[0040] Figure 6 A partial enlarged view of the separation component provided by the present invention;

[0041] Figure 7 This is a step diagram of the method for using the blood component collection and separation device provided by the present invention.

[0042] Reference numerals:

[0043] 1-needle assembly, 101-blood collection needle, 102-three-way connector, 103-needle sheath; 2-multi-channel box; 3-separation assembly, 31-separation belt, 32-dam, 33-separation tower; 4-air bag; 5-blood collection bag, 51-platelet bag, 52-plasma bag; 6-saline puncture device; 7-saline pipeline; 8-saline branch; 9-first control part; 10-second control part; 11-first stop clamp; 12-second stop clamp; 13-multi-interface connector; 14-blood collection blood line; 15-return blood line; 16-anticoagulant line; 17-sampling device; 18-protective net; 19-inlet blood line; 20-outlet blood line; 21-adjustment line; 22-plasma line. DETAILED DESCRIPTION

[0044] The following will be combined with the drawings in the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without creative work are within the scope of protection of the present invention.

[0045] In the present invention, unless otherwise clearly specified and limited, the terms "installed", "connected", "connected", "fixed" and the like should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be a mechanical connection or an electrical connection; it can be a direct connection, or it can be an indirect connection through an intermediate medium, or it can be the internal communication of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0046] The core of the present invention is to provide a blood component collection and separation device, which can reduce the residual blood in vitro, the loss of human white blood cells and the reduction of blood volume in the human body after blood donation, and ensure the health of the blood donor. Another core of the present invention is to provide a method of using the blood component collection and separation device, which reduces the loss of blood cells and white blood cells of the blood donor and effectively replenishes the blood volume of the human body.

[0047] Please refer to Figures 1 to 4 A blood component collection and separation device includes a needle assembly 1, a multi-channel box 2, a saline bag, a separation assembly 3, an air bag 4, a blood collection bag 5, an anticoagulant puncture device and a saline puncture device 6. Specifically, the multi-channel box 2 is connected to the needle assembly 1, the separation assembly 3, the air bag 4, the blood collection bag 5, and the anticoagulant puncture device through a pipeline. The anticoagulant and the multi-channel box 2 are connected through the anticoagulant puncture device, so that the anticoagulant enters the pipeline after passing through the multi-channel box 2, thereby avoiding the phenomenon of blood coagulation during the blood collection process. Blood is collected through the needle assembly 1, and the blood flows into the multi-channel box 2 through the pipeline. The multi-channel box 2 transports the blood to the separation assembly 3 through the pipeline for separation, thereby separating the components in the blood. The separated blood components are transported to the multi-channel box 2, the blood collection bag 5, and the human body through the pipeline.

[0048] The saline puncture device 6 is connected with a filter and is connected to the multi-channel box 2 through a saline pipeline 7. The physiological saline is connected to the multi-channel box 2 through the saline puncture device 6 and the saline pipeline 7. The filter is provided to achieve the effects of sterilization and filtration to ensure that the composition of the physiological saline entering the multi-channel box 2 is stable. After the blood collection is completed, the physiological saline can enter the multi-channel box 2 and the separation component 3 through the saline pipeline 7, and the residual blood can be back-flushed into the multi-channel box 2 and the separation component 3, so that the blood in the multi-channel box 2 and the separation component 3 is back-flushed into the human body with the physiological saline, which can reduce the residual blood outside the body after blood donation, the loss of human white blood cells, and the reduction of blood volume in the human body, thereby ensuring the health of the blood donor.

[0049] It should be noted that the saline pipeline 7 and the physiological saline bag can be connected in a pluggable manner through the saline puncture device 6. Among them, the saline puncture device 6 is preferably a puncture device with a drip pot.

[0050] With the blood component collection and separation device arranged in the above manner, when the blood collection is completed and the residual blood in the device needs to be back-flushed, the saline in the saline bag can enter the multi-channel box 2, and the residual blood is back-flushed to the multi-channel box 2 and the separation component 3, so that the blood in the multi-channel box 2 and the separation component 3 is back-flushed into the human body along with the saline, which can reduce the residual blood outside the body after blood donation and the loss of human white blood cells, protect the health of the blood donor, and increase the supplement of saline to prevent the reduction of blood volume in the human body.

[0051] Furthermore, a saline branch 8 is provided on the saline pipeline 7 , and the saline branch 8 is connected to the needle assembly 1 .

[0052] By setting up the saline branch 8 so that the physiological saline can pass through the saline branch 8 to reach the needle assembly 1, the physiological saline relies on gravity to push the blood between the saline branch 8 and the needle assembly 1 back into the human body to ensure that the section of the pipeline is unobstructed and coagulation will not occur. When blood is continued to be drawn, the phenomenon of abnormal blood collection due to coagulation will not occur.

[0053] In the above embodiment, the brine branch 8 is provided with a first control member 9 for controlling the on and off of the brine branch 8 .

[0054] During the blood collection process, the first control component 9 is controlled to open to connect the saline bag and the needle assembly 1, so that the saline in the saline bag can enter the needle assembly 1 through the saline branch 8 and flow into the human body, and the blood volume in the human body is prevented from decreasing by replenishing the saline. When the blood collection process is paused, the first control component 9 can be operated at any time to allow the saline in the saline bag to rely on gravity to push the blood between the pipeline and the needle assembly 1 back into the human body, so as to ensure that the section of the pipeline is unobstructed and coagulation will not occur.

[0055] The first control element 9 can also be used to control the flow rate of the solution in the brine branch 8 .

[0056] In the above situation, the brine pipeline 7 is provided with a second control member 10 for controlling the on and off of the brine pipeline 7, and the junction between the brine branch 8 and the brine pipeline 7 is located between the second control member 10 and the filter.

[0057] By adjusting the opening and closing of the second control component 10, the connection and disconnection of the physiological saline bag and the multi-channel box 2 are controlled. When it is necessary to back-flush the residual blood in the device, the second control component 10 is opened to make the saline pipeline 7 a passage, so that the physiological saline in the physiological saline bag can enter the saline pipeline 7, and the residual blood is back-flushed to the multi-channel box 2 and the separation component 3, so that the blood in the multi-channel box 2 and the separation component 3 is back-flushed into the human body along with the physiological saline, which can reduce the residual blood outside the body after blood donation and the loss of human white blood cells, and protect the health of the blood donor.

[0058] As a preferred embodiment, the first control member 9 and the second control member 10 are one of a stop clamp and a flow control valve, or the first control member 9 and the second control member 10 are one of a peristaltic pump and a control valve on a separator. In practical applications, there is no limitation to this, and other feasible methods may also be used.

[0059] The second control element 10 is preferably a flow regulator, which is manually operated, and can also be a manual clamping valve.

[0060] In one embodiment, please refer to Figure 1 The blood collection bag 5 includes a platelet bag 51 for storing platelets, and the platelet bag 51 is provided with at least one, at least one platelet bag 51 is connected to the multi-channel box 2 through a first pipeline, and the first pipeline is provided with a first stop clamp 11 for controlling the opening and closing of the first pipeline. In this embodiment, two platelet bags 51 are provided.

[0061] It can be understood that the platelets separated by the separation component 3 enter the multi-channel box 2 and enter the platelet bag 51 through the first pipeline. When the platelets in the platelet bag 51 are full, the first stop clamp 11 can be closed.

[0062] The platelet bag 51 is connected to a sample bag for storing platelet samples.

[0063] In another embodiment, a second pipeline is provided on the saline pipeline 7, the second pipeline is connected to a plasma bag 52, and a second stop clamp 12 for controlling the on-off of the second pipeline is provided on the second pipeline.

[0064] It should be noted that the original plasma bag 52 is retained, and the plasma bag 52 is connected to the saline pipeline 7 through the second pipeline. When the residual blood needs to be flushed back, the second stop clamp 12 of the second pipeline is closed, and the second control component 10 of the saline pipeline 7 is opened, and the physiological saline can enter the saline pipeline 7 to replace the original plasma for residual blood flushing, and the centrifuge is controlled to rotate forward and reverse, and the separation tower 33 is shaken, so that the white blood cells in the separation tower 33 are more likely to follow the physiological saline back into the human body. When the blood collection process is paused, the first control component 9 can be operated at any time to allow the physiological saline to push the blood between the saline branch 8 and the needle assembly 1 back into the human body by gravity, thereby ensuring that the pipeline section is unobstructed and no coagulation occurs.

[0065] Because the plasma bag 52 is retained, the solution retains the function of collecting plasma, and an extra portion of plasma can be collected, generally 200 mL of plasma can be collected. After collecting plasma, the second stop clamp 12 can be used to close the second pipeline, and the second control component 10 can be opened to use the normal saline backwash function.

[0066] The second stop clamp 12 is preferably a manual clamp, which is manually operated, or it can be an electric control valve or the like.

[0067] This application includes four implementation modes. The first one is to only add a brine pipeline 7, such as Figure 1 The second is to add a salt water branch 8 on the basis of the first, such as Figure 2 The third is to add a plasma bag 52 on the basis of the first, such as Figure 3 The fourth type is to add a plasma bag 52 on the basis of the second type, such as Figure 4 shown.

[0068] In the first embodiment, there is only a saline backwash function; in the second embodiment, there are saline backwash and the function of preventing blood coagulation when blood collection is paused; in the third embodiment, there are saline backwash and plasma collection functions; in the fourth embodiment, there are saline backwash, the function of preventing blood coagulation when blood collection is paused and the function of collecting plasma.

[0069] In the fourth embodiment, before blood collection, the second control component 10 on the saline pipeline 7 connected to the multi-channel box 2 is first closed to disconnect the physiological saline bag from the multi-channel box 2 to prevent the physiological saline in the physiological saline bag from entering the multi-channel box 2 from the saline pipeline 7, and then the first control component 9 on the saline branch 8 connected to the needle assembly 1 is opened, and the saline puncture device 6 on the saline branch 8 is inserted into the socket of the physiological saline bag to connect the physiological saline bag and the needle assembly 1. By connecting the physiological saline bag and the needle assembly 1, the physiological saline in the physiological saline bag can enter the needle assembly 1 through the saline branch 8. After the physiological saline reaches the multi-port connector 13 on the saline branch 8, the first control component 9 is closed to complete the preparations before blood collection and start blood collection. The blood collection process is a conventional technical means.

[0070] During the blood collection process, when the blood collection is paused, the first control member 9 is opened to allow the saline to enter the needle assembly 1 through the multi-port connector 13 and flow into the human body. That is to say, when the blood collection process is paused, the first control member 9 can be operated at any time to allow the saline in the saline bag to rely on gravity to push the blood between the multi-port connector 13 and the needle assembly 1 back into the human body to ensure that the section of the pipeline is unobstructed and coagulation will not occur. When blood collection continues, the phenomenon of abnormal blood collection due to coagulation will not occur. When a blood donation reaction occurs, the blood volume can be replenished in time through the pipeline to alleviate the blood donation reaction. When the blood collection is completed, the second control member 9 is opened. 10, so that the saline enters the multi-channel box 2, flows through the separation tower 33 and then flows into the human body. That is to say, when the residual blood in the device needs to be flushed back, the second control member 10 is opened to make the saline pipeline 7 a passage, so that the saline in the saline bag can enter the saline pipeline 7, and the residual blood is back-flushed to the multi-channel box 2 and the separation tower 33, the separation belt 31, the adjustment pipeline 21, and the plasma pipeline 22, so that the blood in the multi-channel box 2 and the separation tower 33 is flushed back into the human body with the saline, which can reduce the residual blood and human leukocyte loss in the body after blood donation, protect the health of the blood donor, and increase the saline supplement to prevent the blood volume in the body from decreasing. With this embodiment, the blood volume in the body is prevented from decreasing by increasing the saline supplement, and the majority of leukocytes in the separation tower 33 are prevented from gathering and being unable to effectively flush back into the human body, so as to reduce the loss of human leukocytes, reduce the residual blood in the body after blood donation, protect the health of the blood donor, and prevent blood coagulation when the device is paused.

[0071] On the basis of the above embodiment, the needle assembly 1 is connected to the multi-interface connector 13, and the multi-interface connector 13 is used to connect the blood collection tube line 14, the blood return tube line 15, the anticoagulant line 16 and the saline branch 8. The blood collection tube line 14, the blood return tube line 15, and the anticoagulant line 16 are all connected to the multi-channel box 2.

[0072] It can be understood that by setting the multi-interface connector 13, the needle assembly 1 is connected with the blood collection tube 14, the return blood tube 15, the anticoagulant tube 16, and the saline branch 8, so that the collected blood can enter the multi-channel box 2 through the blood collection tube 14, and the saline branch 8 can transport the saline in the saline bag to the multi-interface connector 13 and then enter the human body from the needle assembly 1 to replenish the blood drawn from the human body to prevent the reduction of blood volume in the human body. At the same time, the multi-interface connector 13 and the needle assembly can be connected by the saline. 1 is pushed back into the human body to ensure that the section of the pipeline is unobstructed and no coagulation will occur after the blood collection is suspended. The anticoagulant is transported to the multi-channel box 2, the multi-interface connector 13 and the needle assembly 1 through the anticoagulant pipeline 16 to avoid blood coagulation in the multi-channel box 2, the multi-interface connector 13 and the needle assembly 1 to block the pipeline. The separated plasma, red blood cells and other components are returned to the human body through the blood return line 15, and the components in the multi-channel box 2, the separation assembly 3 and various pipelines are flushed back to the human body through the saline pipeline 7.

[0073] As a preferred embodiment, a filter is provided on the anticoagulant pipeline 16 .

[0074] It should be noted that the anticoagulant is filtered by providing a filter to ensure that the composition of the anticoagulant entering the multichannel box 2 is stable.

[0075] Please refer to Figure 5 The needle assembly 1 includes a blood collection needle 101, which is connected to one interface of the multi-interface connector 13 through a three-way connector 102. The other interface of the three-way connector 102 is connected to a sampling tube of the sampling device 17. The sampling tube is provided with a third stop clamp for controlling the flow of blood in the sampling tube.

[0076] It can be understood that when collecting blood, the third stop clamp is first opened, and the blood collection needle 101 is inserted into the blood vessel. Part of the blood enters the three-way connector 102 through the channel of the blood collection needle 101, and part of the blood enters the sampling tube. The blood entering the sampling tube flows to the sampling device 17 to provide a sample for subsequent analysis of blood components. When the sampling device 17 is full of blood, the third stop clamp is closed to break the circuit between the sampling device 17 and the three-way connector 102, so that all the blood collected by the blood collection needle 101 enters the multi-interface connector 13 through the three-way connector 102, and finally enters the multi-channel box 2 through the blood collection tube path 14.

[0077] The blood collection needle 101 is covered with a needle sheath 103 to protect the blood collection needle 101 from being contaminated.

[0078] In the above embodiment, the multichannel box 2 is connected to the separation component 3 through a blood transfusion tube bundle, the outer cover of the blood transfusion tube bundle is provided with a protective net 18, and the blood transfusion tube bundle includes an inlet blood line 19 for conveying blood to the separation component 3, an outlet blood line 20 for conveying separated platelets to the multichannel box 2, an adjustment line 21 for conveying separated plasma and red blood cells to the multichannel box 2, and a plasma line 22 for conveying separated plasma to the multichannel box 2.

[0079] It should be noted that the blood entering the multichannel box 2 through the blood collection tube line 14 enters the separation component 3 through the blood inlet line 19, the separated platelets are transported to the multichannel box 2 through the blood outlet line 20, and the platelets entering the multichannel box 2 enter the platelet bag 51 through the first pipeline and the parallel branch; the separated plasma is transported to the multichannel box 2 through the plasma pipeline 22, and the plasma entering the multichannel box 2 flows back into the human body through the blood return line 15; the separated plasma and red blood cells are transported to the multichannel box 2 through the adjustment pipeline 21, when a plasma bag 52 is provided, a part of the plasma and red blood cells can enter the plasma bag 52 through the second pipeline, when the plasma bag 52 is full of plasma and red blood cells, the other part can flow back into the human body through the blood return line 15, and when the plasma bag 52 is not provided, all the plasma and red blood cells directly flow back into the human body through the blood return line 15.

[0080] Please refer to Figure 6 The separation component 3 includes a separation belt 31, a dam 32 and a separation tower 33. The separation belt 31 is arranged in the centrifuge, the dam 32 is arranged in the separation belt 31, and the dam 32 is connected to the blood outlet line 20, the adjustment line 21 and the plasma line 22. The separation tower 33 is arranged in the blood outlet line 20.

[0081] It can be understood that, by installing the separation belt 31 on the separator of the equipment, the blood is subjected to the centrifugal force to form layers when passing through the separation belt 31, and the red blood cells, the white film layer (including white blood cells and platelets, etc.), and the plasma are separated; the white film layer enters the separation tower 33, which is equivalent to further centrifugation, and the platelets in the white film layer can be separated, so that the platelets enter the multichannel box 2 through the blood outlet line 20, and the white blood cells remain in the separation tower 33; the separated blood components are separated by the dam 32 and enter different pipelines.

[0082] Please refer to Figure 7 , a method for using a blood component collection and separation device, applied to the above-mentioned blood component collection and separation device, the method for using comprises:

[0083] Step S1, inserting the saline puncture device 6 into the saline bag to connect the saline bag and the multi-channel box 2;

[0084] Step S2, when blood sampling is completed, open the second control component 10 to allow the physiological saline to enter the multi-channel box 2, flow through the separation belt 31, the separation tower 33, the adjustment pipeline 21, the plasma pipeline 22, and then flow into the human body.

[0085] When collecting blood, first insert the saline puncture device 6 into the saline bag to connect the saline bag and the multi-channel box 2, and then carry out the normal blood collection process. When the blood collection is completed, open the second control component 10 to allow the saline to enter the multi-channel box 2, flow through the separation belt 31, the separation tower 33, the adjustment pipeline 21, and the plasma pipeline 22, and then flow into the human body, thereby flushing the plasma components remaining in the multi-channel box 2, the separation belt 31, the separation tower 33, the adjustment pipeline 21, and the plasma pipeline 22 back to the human body, which can reduce the residual blood outside the body after blood donation, the loss of human white blood cells, and the reduction of blood volume in the human body, thereby ensuring the health of the blood donor.

[0086] In the above embodiment, after the second control member 10 is opened, the method further includes:

[0087] The centrifuge is turned on to shake the separation column 33 .

[0088] In this embodiment, the centrifuge can be turned on to rotate forward and reversely, thereby oscillating the white blood cells and other plasma components in the separation tower 33, so that the white blood cells in the separation tower 33 are more easily flushed back into the human body with the physiological saline, thereby reducing the loss of white blood cells in the human body. It can also be achieved by adding an oscillator to the separator, and there is no limitation on the method of oscillating the separation tower 33, as long as the above technical effect can be achieved.

[0089] Preferably, the process of inserting the saline puncture device 6 into the physiological saline bag also includes:

[0090] Connect the saline bag and the needle assembly 1;

[0091] Open the first control member 9, and after the physiological saline reaches the multi-port connector 13, close the first control member 9 to collect blood;

[0092] When blood sampling is suspended, the first control member 9 is opened to allow physiological saline to enter the needle assembly 1 through the multi-port connector 13 and flow into the human body.

[0093] During the process of inserting the saline puncture device 6 into the saline bag, the saline bag and the needle assembly 1 are also connected. Before blood collection, the first control component 9 is opened to allow the saline to enter the saline branch 8. After the saline reaches the multi-port connector 13, the first control component 9 is closed to collect blood. When blood collection is paused, the first control component 9 is opened to allow the saline to enter the needle assembly 1 through the multi-port connector 13. The saline pushes the blood between the saline branch 8 and the needle assembly 1 back into the human body by gravity to ensure that the section of the pipeline is unobstructed and coagulation does not occur. When blood collection continues, the phenomenon of abnormal blood collection due to coagulation will not occur.

[0094] In summary, the blood component collection and separation device provided by the present invention has four advantages. The first is to reduce the residual blood outside the body after blood donation, thereby ensuring the health of the blood donor. The second is to prevent blood coagulation when the equipment is paused. The third is to increase the supplement of physiological saline to prevent the reduction of blood volume in the human body. The fourth is to solve the problem that most white blood cells gather in the separation tower 33 and cannot be effectively flushed back, thereby reducing the loss of white blood cells in the human body.

[0095] It should be noted that, in this specification, relational terms such as first and second are merely used to distinguish one entity from other entities, but do not necessarily require or imply any actual relationship or order between these entities.

[0096] The various embodiments in this specification are described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the various embodiments can be referenced to each other.

[0097] The above is a detailed introduction to a blood component collection and separation device and a method of use provided by the present invention. This article uses specific examples to illustrate the principles and implementation methods of the present invention. The description of the above embodiments is only used to help understand the method of the present invention and its core idea. It should be pointed out that for ordinary technicians in this technical field, without departing from the principle of the present invention, several improvements and modifications can be made to the present invention, and these improvements and modifications also fall within the scope of protection of the claims of the present invention.

Claims

1. A blood component collection and separation device, characterized in that: include: Needle assembly (1); A multi-channel box (2) is connected to the needle assembly (1), the separation assembly (3), the air bag (4), the blood collection bag (5) and the anticoagulant puncture device through pipelines; A saline puncture device (6), wherein the saline puncture device (6) is connected to a filter and is connected to the multi-channel box (2) via a saline pipeline (7).

2. The blood component collection and separation device according to claim 1, characterized in that: The saline pipeline (7) is provided with a saline branch (8), and the saline branch (8) is connected to the needle assembly (1).

3. The blood component collection and separation device according to claim 2, characterized in that: The salt water branch (8) is provided with a first control component (9) for controlling the on and off of the salt water branch (8).

4. The blood component collection and separation device according to claim 3, characterized in that: The brine pipeline (7) is provided with a second control component (10) for controlling the on / off state of the brine pipeline (7); the junction between the brine branch (8) and the brine pipeline (7) is located between the second control component (10) and the filter.

5. The blood component collection and separation device according to claim 4, characterized in that: The first control component (9) and the second control component (10) are one of a stop clamp and a flow control valve, or the first control component (9) and the second control component (10) are one of a peristaltic pump and a control valve on a separator.

6. The blood component collection and separation device according to any one of claims 1 to 5, characterized in that: The blood collection bag (5) comprises a platelet bag (51) for storing platelets, the platelet bag (51) being provided with at least one, at least one of the platelet bags (51) being connected to the multichannel box (2) via a first pipeline, the first pipeline being provided with a first stop clamp (11) for controlling the on and off of the first pipeline.

7. The blood component collection and separation device according to claim 6, characterized in that: The saline pipeline (7) is provided with a second pipeline, the second pipeline is connected to a plasma bag (52), and the second pipeline is provided with a second stop clamp (12) for controlling the on and off of the second pipeline.

8. The blood component collection and separation device according to claim 4, characterized in that: The needle assembly (1) is connected to a multi-interface connector (13), and the multi-interface connector (13) is used to connect a blood collection tube line (14), a blood return tube line (15), an anticoagulant line (16), and the saline line (7); the blood collection tube line (14), the blood return tube line (15), and the anticoagulant line (16) are all connected to the multi-channel box (2).

9. The blood component collection and separation device according to claim 8, characterized in that: The anticoagulant pipeline (16) is provided with a filter.

10. The blood component collection and separation device according to claim 8, characterized in that: The needle assembly (1) comprises a blood collection needle (101), the blood collection needle (101) being connected to one interface of the multi-interface connector (13) via a three-way connector (102), the other interface of the three-way connector (102) being connected to a sampling tube of a sampling device (17), the sampling tube being provided with a third stop clamp for controlling the flow of blood in the sampling tube.

11. The blood component collection and separation device according to claim 10, characterized in that: The multichannel box (2) is connected to the separation component (3) via a blood transfusion bundle, the outer portion of the blood transfusion bundle is provided with a protective net (18), the blood transfusion bundle comprises an inlet blood line (19) for conveying blood to the separation component (3), an outlet blood line (20) for conveying separated platelets to the multichannel box (2), an adjustment line (21) for conveying separated plasma and red blood cells to the multichannel box (2), and a plasma line (22) for conveying separated plasma to the multichannel box (2).

12. The blood component collection and separation device according to claim 11, characterized in that: The separation component (3) comprises a separation belt (31), a dam (32) and a separation tower (33); the separation belt (31) is arranged in a centrifuge; the dam (32) is arranged in the separation belt (31); the dam (32) is connected to the blood outlet line (20), the adjustment line (21) and the plasma line (22); and the separation tower (33) is arranged in the blood outlet line (20).

13. A method for using a blood component collection and separation device, characterized in that: Applied to the blood component collection and separation device according to claim 12, the method of use comprises: Inserting a saline puncture device (6) into a saline bag to connect the saline bag to the multichannel box (2); When blood sampling is completed, the second control component (10) is opened to allow physiological saline to enter the multi-channel box (2), flow through the separation belt (31), the separation tower (33), the adjustment pipeline (21), the plasma pipeline (22), and then flow into the human body.

14. The method for using the blood component collection and separation device according to claim 13, characterized in that: After the second control member (10) is opened, the method further comprises: The centrifuge is turned on to shake the separation column (33).

15. The method for using the blood component collection and separation device according to claim 13, characterized in that: The process of inserting the saline puncture device (6) into the physiological saline bag also includes: Connecting the physiological saline bag and the needle assembly (1); Opening the first control component (9), and after the physiological saline reaches the multi-interface connector (13), closing the first control component (9) to perform blood sampling; When blood sampling is paused, the first control component (9) is opened to allow physiological saline to enter the needle assembly (1) through the multi-interface connector (13) and flow into the human body.

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