Spraying device for coprophilous fungus transplantation

Abstract

The invention provides a spraying device for coprophilous fungus transplantation. The spraying device comprises a tank body and a cover body component, the tank body is used for accommodating coprophilous fungus liquid to be transplanted; the cover body component comprises a cover body, a pipeline and an air pump; the cover body seals an opening in the upper end of the tank body; a first round hole and a second round hole are formed in the cover body; the first end of the pipeline is closed, the second end of the pipeline is open, the first end of the pipeline is inserted into the intestine of a subject through an instrument hole of the colonoscope, and a plurality of spraying holes are formed along the peripheral surface of the first end of the pipeline; the second end of the pipeline penetrates through the cover body through the first round hole and then is inserted into the bottom of the tank body; an air pump is mounted on the upper side of the cover body; the output end of the air pump is inserted into the second round hole; the air pump is used for pumping external air into the tank body, so that the air pressure in the tank body is increased, under the action of the air pressure, the coprophilous bacteria liquid in the tank body is pushed into the pipeline through the second end of the pipeline and conveyed to the first end of the pipeline, and the coprophilous bacteria liquid is sprayed to the inner circumferential surface of the intestine of a subject through the spraying holes in the circumferential surface of the first end of the pipeline.

Description

Technical Field

[0001] The present application relates to a fecal microbiota transplantation medical device, and more particularly to a spraying device for fecal microbiota transplantation. Background Art

[0002] Fecal microbiota transplantation, also known as intestinal flora transplantation (FMT), is a medical therapy that transfers the flora in the feces of healthy people to the intestines of patients to adjust and restore the intestinal microbial community of patients. Its principle is based on the important role of intestinal flora in maintaining human health and immune function.

[0003] The principle of FMT can be briefly summarized into the following steps: 1. Donor screening: Healthy people are selected as donors and undergo strict screening, including checking for infectious diseases, autoimmune disease history, and drug use. Ensure that the donor's feces contains rich beneficial bacteria.

[0004] 2. Sample preparation: Obtain fresh stool samples from donors and process them. The processing usually includes dilution, stirring and filtration to obtain a liquid or suspension containing the bacterial flora.

[0005] 3. Transplantation process: The processed fecal sample is introduced into the recipient's intestines in different ways. Common methods include direct instillation through a nasogastric tube or colonoscope, or oral administration in capsule form.

[0006] 4. Reconstruction of the microbiota: The donor's microbiota will colonize the recipient's intestines and coexist with the original microbiota. These beneficial microbiota can replicate and grow to restore the balance of the intestinal microbiota.

[0007] During the transplantation process, the clinic currently uses a syringe to suck out the fecal bacteria liquid, and then uses a tube to insert the fecal bacteria liquid into the subject's intestines through the instrument channel of the colonoscope to push the fecal bacteria liquid into the intestines. The operator sprays the fecal bacteria liquid while withdrawing the tube, so that the fecal bacteria liquid is sprayed into the intestines.

[0008] Fecal bacteria liquid needs to be sprayed evenly on the inner surface of the intestine, so that the success rate of transplantation is higher. However, there is currently no pipeline dedicated to the spraying of fecal bacteria liquid. Even if multiple openings are opened on the side wall of the pipeline, the uniformity of the spraying of fecal bacteria liquid is not very ideal. In addition, the viscosity of fecal bacteria liquid is relatively high, and it is very difficult to push it with a syringe. Moreover, the capacity of a standard syringe is limited, and the spraying amount of fecal bacteria liquid is relatively large, and the syringe needs to be filled repeatedly. The fecal bacteria liquid in the container is easy to be clear on the top and turbid on the bottom after standing for a long time. In this way, the consistency of the fecal bacteria liquid is poor, which makes the concentration of the fecal bacteria liquid sprayed front and back in the intestine vary greatly, affecting the transplantation effect.

[0009] In addition, the existing clinical methods require at least two people to work together, one person operates the syringe to inject the fecal bacteria liquid; the other person operates the colonoscope so that the pipeline injection head is gradually withdrawn along with the colonoscope. Summary of the invention

[0010] In view of the above problems, the present application aims to propose a spraying device for fecal microbiota transplantation, which only requires one person to complete the spraying operation. The present application aims to propose a spraying device for fecal microbiota transplantation, which facilitates the uniform spraying of fecal microbiota liquid in the intestine.

[0011] The spraying device for fecal microbiota transplantation of the present application comprises: a tank body and a cover member; The tank is used to contain the fecal bacteria liquid to be transplanted; The cover member includes a cover body, a pipeline, and an air pump; the cover body and the tank body are airtightly installed together, and the upper end opening of the tank body is closed; a first circular hole and a second circular hole are formed on the cover body; the first end of the pipeline is closed, and the second end is open, and the first end of the pipeline is inserted into the intestine of the subject through the instrument hole of the colonoscope, and a plurality of injection holes are formed along the outer circumferential surface of the first end of the pipeline; the second end of the pipeline passes through the cover body through the first circular hole and is inserted into the bottom of the tank body; the pipeline and the first circular hole are kept airtight; an air pump is installed on the upper side of the cover body; the output end of the air pump is inserted into the second circular hole; the output end of the air pump and the second circular hole are kept airtight; the air pump is used to draw external air into the tank body, so that the air pressure in the tank body increases, and under the action of the air pressure, the fecal bacteria liquid in the tank body is pushed into the pipeline through the second end of the pipeline and transported to the first end of the pipeline, and sprayed onto the inner circumferential surface of the subject's intestine through the injection holes on the circumferential surface of the first end of the pipeline.

[0012] Preferably, the cover body is also formed with a third circular hole; a motor is installed on the cover body, and the output shaft of the motor extends into the tank body through the third circular hole. At least one impeller is installed on the output shaft of the motor to stir the fecal bacteria liquid in the tank body to make its concentration uniform.

[0013] Preferably, a balloon with a columnar outer circumference is formed at the first end of the pipeline; the balloon is made of a plastic film with a certain thickness; and the injection hole is formed on the circumference of the balloon.

[0014] Preferably, when the balloon is in a deflated state, its diameter is smaller than the diameter of the adjacent tubing portion; when the balloon is in an expanded state, its diameter is larger than the diameter of the adjacent tubing portion, so that the balloon is closer to the inner circumference of the subject's intestine.

[0015] Preferably, a disturbance handle is provided in the middle of the pipeline, and the disturbance handle is outside the colonoscope, so that the pipeline can be reciprocated in the instrument hole of the colonoscope with the axis of the pipeline as the rotation axis by manipulating the disturbance handle, thereby the injection hole in the subject's intestine correspondingly swings back and forth with the axis of the pipeline as the rotation axis, so that the fecal bacteria liquid is evenly sprayed onto the inner circumference of the subject's intestine.

[0016] Preferably, a convex ridge extending along the length direction of the pipeline is formed on the outer side surface of the pipeline; the convex ridge is located at least in the middle of the pipeline; the disturbance handle includes a mounting ring and a handle body; the handle body and the mounting ring are formed integrally; the handle body extends outward from the mounting ring; the shape of the inner circumference of the mounting ring corresponds to the shape of the outer circumference of the pipeline; a groove is formed on the inner circumference of the mounting ring; the convex ridge of the pipeline is engaged in the groove.

[0017] Preferably, the convex ridges are formed on opposite sides of the pipeline respectively.

[0018] Preferably, there are multiple impellers; the multiple impellers are evenly distributed along the length direction of the output shaft of the motor.

[0019] Preferably, the output shaft of the motor is located at the center of the cover body.

[0020] The spraying device for fecal microbiota transplantation of the present application uses an air pump to pressurize the fecal microbiota liquid, making the operation labor-saving. No special person is needed to pressurize the fecal microbiota liquid, and only one person is needed to operate at the colonoscope; the spraying device for fecal microbiota transplantation of the present application can spray as close to the inner surface of the intestine as possible by inflating the balloon, and the spraying position is easier to control; the spraying device for fecal microbiota transplantation of the present application can realize repeated swinging of the spraying balloon around the axis by a disturbance handle, so as to realize a more uniform distribution of the fecal microbiota liquid on the inner surface of the intestine; the spraying device for fecal microbiota transplantation of the present application stirs the fecal microbiota liquid by a motor, so that the fecal microbiota liquid is always uniform, ensuring that the concentration of the fecal microbiota liquid sprayed in the early stage and the fecal microbiota liquid sprayed in the later stage are consistent, and the uniformity of the fecal microbiota transplantation is guaranteed in terms of fecal microbiota concentration. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 This is a schematic diagram of the three-dimensional structure of the spraying device used for fecal microbiota transplantation in the present application.

[0022] Figure 2 , 3 This is a schematic diagram of the three-dimensional structure of the cover component of the spraying device for fecal microbiota transplantation of the present application.

[0023] Figure 4 This is a schematic diagram of the three-dimensional structure of the disturbance handle of the spraying device for fecal microbiota transplantation of the present application.

[0024] Figure 5 for Figure 4Schematic diagram of the main structure of the disturbance handle. DETAILED DESCRIPTION

[0025] Below, in conjunction with the accompanying drawings, the spraying device for fecal microbiota transplantation of the present application is described in detail.

[0026] The spraying device for fecal microbiota transplantation of the present application includes: a tank body 10 and a cover member.

[0027] The tank body 10 is used to contain the fecal bacteria liquid to be transplanted; the tank body 10 is made of transparent plastic or glass, and is printed with a capacity scale to facilitate the operator to grasp the amount of the fecal bacteria liquid.

[0028] The cover component includes a cover body 20 , a pipeline 50 , and an air pump 30 .

[0029] The cover body 20 is installed together with the can body 10 in an airtight manner, for example, by means of threads, to seal the upper opening of the can body 10 .

[0030] The cover body 20 is formed with a first circular hole and a second circular hole.

[0031] The first end of the pipeline 50 is closed and the second end is open. The first end of the pipeline 20 is inserted into the intestine of the subject through the instrument hole of the colonoscope, and a plurality of injection holes are formed along the outer circumferential surface of the first end of the pipeline; the second end of the pipeline 50 passes through the cover body 20 through the first circular hole and is inserted into the bottom of the tank body 10; the pipeline 50 and the first circular hole are kept airtight, for example, by a sealing ring.

[0032] An air pump 30 is installed on the upper side of the cover body 20; the output end of the air pump 30 is inserted into the second circular hole; the output end of the air pump 30 and the second circular hole are kept airtight. The air pump 30 is used to draw external air into the tank body 10, so that the air pressure in the tank body 10 increases, and under the action of the air pressure, the fecal bacteria liquid in the tank body is pushed into the pipeline 50 through the second end of the pipeline 50 and transported to the first end of the pipeline 50, and sprayed onto the inner circumference of the subject's intestine through the spray hole on the circumference of the first end of the pipeline 50.

[0033] In one embodiment, the cover body 20 is also formed with a third circular hole; a motor 40 is installed on the cover body 20, and an output shaft 41 of the motor 40 extends into the tank body 10 through the third circular hole. At least one impeller 42 is installed on the output shaft 41 of the motor to stir the fecal bacteria liquid in the tank body to make its concentration uniform.

[0034] In a preferred embodiment, a balloon 51 with a columnar outer circumference is formed at the first end of the pipeline 50 ; the balloon 51 is made of a plastic film with a certain thickness; and the injection hole is formed on the circumference of the balloon 51 .

[0035] When the balloon 51 is in a contracted state, its diameter is smaller than the diameter of the adjacent tubing portion, so that the balloon 51 can pass through the instrument channel and enter the intestine easily; when the balloon 51 is in an expanded state, its diameter is larger than the diameter of the adjacent tubing portion, so that the balloon is closer to the inner circumference of the subject's intestine, so that the inner circumference of the intestine can be easily and accurately sprayed.

[0036] A disturbance handle 53 is provided in the middle of the pipeline 50, and the disturbance handle 53 is outside the colonoscope. By manipulating the disturbance handle, the pipeline is made to swing back and forth in the instrument hole of the colonoscope with the axis of the pipeline as the rotation axis, thereby the injection hole in the subject's intestine correspondingly swings back and forth with the axis of the pipeline as the rotation axis, so that the fecal bacteria liquid is evenly sprayed onto the inner circumference of the subject's intestine.

[0037] The disturbance handle 53 may be integrally formed on the pipeline 50 , or may be installed on the pipeline 50 .

[0038] In the installation method, one embodiment is that a convex rib 52 extending along the length direction of the pipeline is formed on the outer surface of the pipeline 50; the convex rib 52 is at least located in the middle of the pipeline; the disturbance handle 53 includes a mounting ring and a handle body 53a; the handle body 53a is formed integrally with the mounting ring; the handle body 53a extends outward from the mounting ring; the shape of the inner circumference of the mounting ring corresponds to the shape of the outer circumference of the pipeline 50; a groove 53b is formed on the inner circumference of the mounting ring; the convex rib 52 of the pipeline 50 is engaged in the groove 53b. There is friction between the disturbance handle 53 and the pipeline 50, so that the disturbance handle 53 can be kept stationary on the pipeline. If the position of the disturbance handle is moved, for example, when a colonoscope of different lengths is selected, the position of the disturbance handle on the pipeline can be moved after overcoming the friction between the disturbance handle 53 and the pipeline 50, so that the disturbance handle is always outside the opening of the colonoscope instrument channel, which is convenient for manipulation and forms a swing at the balloon.

[0039] The ridges 52 may be formed on opposite sides of the pipe 50 .

[0040] There are multiple impellers 42; the multiple impellers 42 are evenly distributed along the length direction of the output shaft 41 of the motor, which makes it easier to maintain a uniform concentration of the fecal bacteria liquid in the entire tube body.

[0041] The output shaft 41 of the motor is located at the center of the cover body.

[0042] In addition, since the pipeline needs to be swung by operating the disturbance handle, a steel wire may be added to the inside of the pipeline to increase the axial rigidity of the pipeline.

[0043] When in use, first use a guide wire to insert the pipeline into the instrument channel of the colonoscope, so that the first end of the pipeline is located in the subject's intestine after extending from the instrument channel; then insert the second end of the pipeline into the cover body; after adding the fecal bacteria liquid into the tank body, cover the tank body with the cover body component; start the motor to stir the fecal bacteria liquid at an appropriate speed to make it uniform in concentration throughout the transplantation process; start the air pump, gas continuously enters the tank body, the air pressure in the tank body continuously increases, and the fecal bacteria liquid is squeezed into the pipeline and enters the first end of the pipeline; the balloon expands due to the pressure of the fecal bacteria liquid and approaches the inner peripheral surface of the intestine; the fecal bacteria liquid is continuously ejected from the injection hole under the action of pressure and adheres to the inner peripheral surface of the intestine. The operator holds the colonoscope in one hand, sprays and retreats at the same time, so that the fecal bacteria are evenly distributed in the length direction of the subject's intestine. At the same time, the operator's other hand operates the disturbance handle to make the balloon swing in the intestine, so that the fecal bacteria liquid is more evenly distributed on the intestinal peripheral surface; until the fecal bacteria liquid is sprayed.

[0044] The spraying device for fecal microbiota transplantation of the present application can spray more evenly on the circumference of the intestine, and the concentration of the fecal microbiota liquid sprayed in the early stage and the fecal microbiota liquid sprayed in the later stage is consistent, so that the fecal microbiota liquid in the length direction of the intestine is also uniform and consistent. During the whole process, the fecal microbiota liquid is as airtight as possible, and the odor of the fecal microbiota liquid has little interference with the operator.

Claims

1. A spraying device for fecal microbiota transplantation, comprising: Tank body and cover components; The tank is used to contain the fecal bacteria liquid to be transplanted; The cover member includes a cover body, a pipeline, and an air pump; the cover body and the tank body are airtightly installed together, and the upper end opening of the tank body is closed; a first circular hole and a second circular hole are formed on the cover body; the first end of the pipeline is closed, and the second end is open, and the first end of the pipeline is inserted into the intestine of the subject through the instrument hole of the colonoscope, and a plurality of injection holes are formed along the outer circumferential surface of the first end of the pipeline; the second end of the pipeline passes through the cover body through the first circular hole and is inserted into the bottom of the tank body; the pipeline and the first circular hole are kept airtight; an air pump is installed on the upper side of the cover body; the output end of the air pump is inserted into the second circular hole; the output end of the air pump and the second circular hole are kept airtight; the air pump is used to draw external air into the tank body, so that the air pressure in the tank body increases, and under the action of the air pressure, the fecal bacteria liquid in the tank body is pushed into the pipeline through the second end of the pipeline and transported to the first end of the pipeline, and sprayed onto the inner circumferential surface of the subject's intestine through the injection holes on the circumferential surface of the first end of the pipeline.

2. The spraying device for fecal microbiota transplantation according to claim 1, characterized in that: The cover body is also formed with a third circular hole; a motor is installed on the cover body, and the output shaft of the motor extends into the tank body through the third circular hole. At least one impeller is installed on the output shaft of the motor to stir the fecal bacteria liquid in the tank body to make its concentration uniform.

3. The spraying device for fecal microbiota transplantation according to claim 1, characterized in that: A balloon with a columnar outer circumference is formed at the first end of the pipeline; the balloon is made of a plastic film with a certain thickness; and the injection hole is formed on the circumference of the balloon.

4. The spraying device for fecal microbiota transplantation according to claim 3, characterized in that: When the balloon is in a deflated state, its diameter is smaller than the diameter of the adjacent tubing portion; when the balloon is in an expanded state, its diameter is larger than the diameter of the adjacent tubing portion, so that the balloon is closer to the inner circumference of the subject's intestine.

5. The spraying device for fecal microbiota transplantation according to claim 1 or 3, characterized in that: A disturbance handle is provided in the middle of the pipeline, and the disturbance handle is outside the colonoscope. By manipulating the disturbance handle, the pipeline is made to swing back and forth in the instrument hole of the colonoscope with the axis of the pipeline as the rotating axis, thereby the injection hole in the subject's intestine correspondingly swings back and forth with the axis of the pipeline as the rotating axis, so that the fecal bacteria liquid is evenly sprayed onto the inner circumference of the subject's intestine.

6. The spraying device for fecal microbiota transplantation according to claim 5, characterized in that: A convex ridge extending along the length direction of the pipeline is formed on the outer surface of the pipeline; the convex ridge is located at least in the middle of the pipeline; the disturbance handle includes a mounting ring and a handle body; the handle body and the mounting ring are formed integrally; the handle body extends outward from the mounting ring; the shape of the inner circumference of the mounting ring corresponds to the shape of the outer circumference of the pipeline; a groove is formed on the inner circumference of the mounting ring; the convex ridge of the pipeline is engaged in the groove.

7. The spraying device for fecal microbiota transplantation according to claim 6, characterized in that: The convex ridges are respectively formed on opposite sides of the pipeline.

8. The spraying device for fecal microbiota transplantation according to claim 2, characterized in that: There are multiple impellers; the multiple impellers are evenly distributed along the length direction of the output shaft of the motor.

9. The spraying device for fecal microbiota transplantation according to claim 8, characterized in that: The output shaft of the motor is located at the center of the cover body.

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