Skin care composition containing bakuchiol and rosmarinic acid and application thereof

Abstract

The invention discloses a skin care composition containing bakuchiol and rosmarinic acid and application of the skin care composition. The composition comprises bakuchiol and rosmarinic acid in a physiologically acceptable medium. According to the composition, the bakuchiol and the rosmarinic acid are compounded for use, and the composition shows a very good synergistic effect in the aspect of inhibiting lipid peroxidation.

Description

Technical Field

[0001] The invention belongs to the field of cosmetics, and in particular relates to a skin care composition comprising bakuchiol and rosmarinic acid and application thereof. Background Art

[0002] The main components of skin lipids are glycerides, wax esters, squalene, free fatty acids, cholesterol and cholesterol esters. They are mainly derived from sebum secretion and epidermal cells. Sebum is very important for maintaining the barrier function. It has the functions of locking in moisture, moisturizing, resisting infection, neutralizing pH, etc., and can maintain the ecological stability of resident bacteria on the surface of human skin.

[0003] However, the free fatty acids and squalene in skin lipids are unstable and can be easily oxidized under the influence of pollutants such as PM2.5 and ultraviolet rays. Oxidized lipids can cause many harms to the skin: 1. Squalene peroxidation can generate molecules that damage the physiological functions of cells and tissues and induce inflammation. 2. Cause oxidative aging. 3. Affect the balance of microecology. When too much sebum is oxidized, the distribution of lipids on the skin surface changes, affecting the balance of microecology and disrupting the barrier function. Adding antioxidants is an effective measure to inhibit the harm caused by lipid oxidation.

[0004] Antioxidants used in cosmetics can be divided into water-soluble antioxidants and oil-soluble antioxidants according to solubility; according to the type of compound, they can be divided into phenolic compounds, organic acids and their esters, inorganic acids and their salts, etc. The phenolic compounds include vitamin E, guaiacol, gallic acid and its propyl and amyl esters, butylated hydroxyanisole, butylated hydroxytoluene, 2,5-di-tert-butylhydroquinone, tert-butylhydroquinone, guaiac resin and nordihydroguaiac acid, etc. Organic acids and their esters include oxalic acid, citric acid, tartaric acid, malic acid, thiodipropionic acid, glucuronic acid, isopropyl citrate, maleic acid, succinic acid and glucuronic acid, etc. Inorganic acids and their salts include phosphoric acid and its salts, sodium sulfite and sodium bisulfite, etc. Phenols are oil-soluble and are used for the antioxidant of oily substances; organic acids, inorganic acids and inorganic acid salts are water-soluble and are generally used for the antioxidant of aqueous substances. However, studies have shown that the combined use of water-soluble antioxidants and oil-soluble antioxidants will make it difficult for the two to contact each other in, for example, an O / W emulsified system, and thus fail to exert a synergistic effect. Summary of the invention

[0005] After in-depth research, the inventors of the present application found that oil-soluble bakuchiol and water-soluble rosmarinic acid can exert a synergistic effect in inhibiting lipid peroxidation even in emulsions. Therefore, this combination can be adapted to a variety of formulation systems, such as emulsions, oils, creams, etc.

[0006] The present application provides a skin care composition, and its specific technical solution is as follows:

[0007] 1. A skin care composition, characterized in that: it includes bakuchiol and rosmarinic acid in a physiologically acceptable medium, and the mass ratio of bakuchiol to rosmarinic acid is 1:5 to 5:1.

[0008] 2. The skin care composition according to item 1, characterized in that: the composition also includes an oily component.

[0009] 3. The skin care composition according to item 1 or 2, characterized in that the composition is prepared into one or more of an oil, an emulsion, and a cream.

[0010] 4. Use of the skin care composition according to any one of items 1 to 3 for non-therapeutic purposes on the skin surface to inhibit lipid peroxidation.

[0011] 5. Use of the skin care composition described in any one of items 1 to 3 in the preparation of a product for inhibiting lipid peroxidation.

[0012] 6. The use according to item 4 or 5, wherein the skin care composition is used for one or more of repairing the skin barrier, improving skin dryness, and reducing skin sensitivity.

[0013] 7. The use according to any one of items 4 to 6, wherein the lipid comprises an oil containing an unsaturated bond.

[0014] 8. Use of the skin care composition according to any one of items 1 to 3 in anti-oxidation.

[0015] 9. Use of the skin care composition described in any one of items 1 to 3 in the preparation of antioxidant products.

[0016] 10. Use of the skin care composition according to any one of items 1 to 3 in the preparation of cosmetics.

[0017] This application has the following beneficial effects:

[0018] This application compounds bakuchiol and rosmarinic acid, which can play a synergistic role in inhibiting lipid peroxidation in a variety of formulation systems, broadening the application scenarios of the compound;

[0019] The present application compounds bakuchiol and rosmarinic acid, which can also play a synergistic role in inhibiting lipid peroxidation in the emulsified system, thereby enhancing the anti-lipid oxidation effect of the emulsified system product. DETAILED DESCRIPTION

[0020] The following is a description of the exemplary embodiments of the present application, including various details of the embodiments of the present application to facilitate understanding, which should be considered as merely exemplary. Therefore, it should be recognized by those of ordinary skill in the art that various changes and modifications can be made to the embodiments described herein without departing from the scope and spirit of the present application. Similarly, for clarity and conciseness, the description of well-known functions and structures is omitted in the following description.

[0021] Unless otherwise defined, technical and scientific terms in this specification have the same meaning as those commonly understood by those skilled in the art. Although methods and materials similar or identical to those described herein may be used in experiments or practical applications, the present application still describes the materials and methods below. In the event of a conflict, the present specification, including definitions, shall prevail.

[0022] The present application relates to a composition. The "composition" can achieve the effects described in the present invention. The "composition" includes but is not limited to using the components simultaneously or sequentially. The "simultaneous use" includes using them together in the same preparation or using them separately in different preparations. The "sequential use" includes using them sequentially in different preparations, and there is no restriction on the order of sequential use.

[0023] The present application provides a skin care composition, which has the effect of inhibiting lipid peroxidation. The composition includes a physiologically acceptable medium, which includes bakuchiol and rosmarinic acid. The mass ratio of bakuchiol to rosmarinic acid is 1:5 to 5:1, for example, 1:5, 1:4.5, 1:4, 1:3.5, 1:3, 1:2.5, 1:2, 1:1.5, 1:1, 1.5:1, 2:1, 2.5:1, 3:1, 3.5:1, 4:1, 4.5:1, 5:1, etc.

[0024] The bakuchiol used in this application is the main component of the commonly used Chinese medicine psoralea corylifolia volatile oil, and is a prenylphenol terpene compound. This raw material has good antioxidant and anti-inflammatory effects and has begun to attract much attention in the domestic cosmetics industry. Bakuchiol can be introduced into the composition in any form, such as a pure product, a solution state, or an extract state containing bakuchiol.

[0025] Rosmarinic acid is a natural phenolic acid compound extracted from plants such as Boraginaceae, Lamiaceae and Cucurbitaceae, has good stability, and has good antioxidant, anti-inflammatory and antibacterial effects. The rosmarinic acid used in the present invention is a water-soluble natural phenolic acid compound, which is an important component of the rosemary plant and is usually extracted and separated from rosemary. Rosmarinic acid can be introduced into the composition in any form, such as a pure product, a solution state or an extract state containing rosmarinic acid.

[0026] In some embodiments of the present application, the composition further comprises an oily component.

[0027] The oily components include oily media for forming oils, emulsions, and creams, oil-soluble active ingredients, etc. As oily media, they include but are not limited to oils, waxes, and their derivatives. As oil-soluble active ingredients, they include but are not limited to 3-O-ethyl ascorbic acid, ascorbyl palmitate, ethylhexyl ferulate, tocopherol, tocopherol acetate, ubiquinone, retinol, retinol acetate, phytosterols, ceramides, oil-soluble sunscreens, α-bisabolol, etc.

[0028] As oils, waxes and their derivatives, they include but are not limited to jojoba seed oil, wheat germ oil, castor seed oil, olive oil, avocado oil, decyl oleate, sunflower seed oil, sweet almond oil, peanut oil, carnauba wax, candelilla wax, paraffin, microcrystalline wax, cetyl alcohol, stearyl alcohol, cetyl alcohol, hexadecanoic acid (palmitic acid), octadecanoic acid (stearic acid), dodecanoic acid (lauric acid), myristic acid (myristic acid), eicosanoic acid (arachidic acid), linolenic acid, linoleic acid, oleic acid, caprylic / capric triglyceride, isopropyl isostearate, isopropyl stearate, C12-C14 isoparaffin, etc.

[0029] In some embodiments of the present invention, the composition can be prepared into one or more of an oil, an emulsion, and a cream.

[0030] Among them, oil agents refer to liquid cosmetics containing vegetable oils, animal oils and mineral oils without emulsification. It is a dosage form made of animal and vegetable oils or mineral oils, synthetic (semi-synthetic) oils as solvents and functional ingredients. Oil agents can be divided into liquid and semi-solid states according to their appearance, such as sunscreen, makeup remover, hair wax, hair oil, massage oil, hair conditioner, nourishing hair oil, rancid oil, nail polish, etc.

[0031] Among them, emulsion is emulsified milk, lotion, milk, milk, etc. It is a type of cosmetics formed by one or more liquid phases dispersed in another immiscible liquid phase in the form of liquid droplets. Emulsion is a dispersion system. The dispersed substance is called the dispersed phase (internal phase), and the continuous medium that contains the dispersed phase is called the dispersion medium (external phase). In emulsions, one phase is often water or an aqueous solution, called the aqueous phase; the other phase is a liquid that is immiscible with water, called the oil phase.

[0032] Among them, creams refer to emulsified ointments, creams, honeys, fats and other cosmetics. In other words, it refers to a type of cosmetics that uses emulsifiers or physical methods to make the oil phase and the water phase or powder mix evenly, and presents a solid or semi-solid paste. Common cream products include cleansing creams, massage creams, skin creams, facial masks, eye creams, whitening and freckle creams, sunscreens, concealers, mascara, moisturizing honeys, etc.

[0033] Emulsions and creams are emulsified products, therefore, the composition also includes an emulsifier.

[0034] In some embodiments of the present invention, the composition further comprises an emulsifier.

[0035] Furthermore, the emulsifier is an emulsifier acceptable in the field of cosmetics, and non-limiting examples thereof include the following emulsifiers: anionic surfactants, cationic surfactants, amphoteric surfactants, and nonionic surfactants.

[0036] Examples of the anionic surfactant include sulfonates, sulfate esters, and cholates. For example, anionic surfactants commonly used in the cosmetics field such as sodium dodecyl sulfate, sodium lauryl sulfate, sodium dodecylbenzene sulfonate, and sodium glycocholate may be included.

[0037] Examples of the cationic surfactant include nitrogen-containing organic amine derivatives, such as polyquaternium-7, polyquaternium-10, polyquaternium-49, and other cationic surfactants commonly used in the cosmetics field.

[0038] Examples of zwitterionic surfactants include amino acid-based and betaine-based surfactants. For example, zwitterionic surfactants commonly used in the cosmetics field, such as lauroyl ammonium chloride, cocoyl glutamate, and cocoyl propyl betaine, can be included.

[0039] Examples of nonionic surfactants include polyoxyethylene type, polyol type, alkanolamide type, polyether type, amine oxide type, etc. For example, nonionic surfactants commonly used in the cosmetics field such as PEG-400 hydrogenated castor, polysorbate, sorbitan fatty acid, alkyl glucoside, and decyl glucoside may be included.

[0040] As physiologically acceptable media, their composition, usage amount, etc. can be selected by those skilled in the art according to their knowledge and the type of application scenario required.

[0041] In addition to the components mentioned above, the composition of the present application may also optionally include preservatives, moisturizers, pH adjusters, functional additives, fragrances, pigments and other ingredients; it may also include ingredients that are inevitably introduced with the introduction of bakuchiol and rosmarinic acid.

[0042] In some specific embodiments, the content of bakuchiol in the skin care composition is 0.01wt% to 5wt%, for example, 0.01wt%, 0.02wt%, 0.03wt%, 0.04wt%, 0.05wt%,

[0043] 0.06wt%, 0.07wt%, 0.08wt%, 0.09wt%, 0.1wt%, 0.2wt%, 0.3wt%, 0.4wt%,

[0044] 0.5wt%, 0.6wt%, 0.7wt%, 0.8wt%, 0.9wt%, 1wt%, 1.5wt%, 2.0wt%, 2.5wt%, 3.0wt%, 3.5wt%, 4.0wt%, 4.5wt%, 5.0wt%, and any value and range therebetween.

[0045] In some specific embodiments, the content of rosmarinic acid in the skin care composition is 0.01wt% to 5wt%, for example, 0.01wt%, 0.02wt%, 0.03wt%, 0.04wt%, 0.05wt%,

[0046] 0.06wt%, 0.07wt%, 0.08wt%, 0.09wt%, 0.1wt%, 0.2wt%, 0.3wt%, 0.4wt%,

[0047] 0.5wt%, 0.6wt%, 0.7wt%, 0.8wt%, 0.9wt%, 1wt%, 1.5wt%, 2.0wt%, 2.5wt%, 3.0wt%, 3.5wt%, 4.0wt%, 4.5wt%, 5.0wt%, and any value and range therebetween.

[0048] In some specific embodiments, the composition is a composition for external use on the skin.

[0049] The present invention also provides a method for preparing the skin care composition, and the preparation method only needs to dissolve bakuchiol and rosmarinic acid and mix them uniformly.

[0050] In some specific embodiments, the preparation method comprises dissolving and mixing bakuchiol and rosmarinic acid in a non-aqueous solvent, and the non-aqueous solvent comprises an alcohol solvent.

[0051] In some specific embodiments, the preparation method comprises dissolving and mixing bakuchiol and rosmarinic acid in an oily medium.

[0052] In some specific embodiments, the preparation method comprises dissolving bakuchiol in an oily medium, dissolving rosmarinic acid in an aqueous medium, and forming an emulsion or cream by adding an emulsifier.

[0053] In some specific embodiments, the preparation method comprises mixing bakuchiol, rosmarinic acid and an emulsifier, and adding a solvent for dilution as needed to form an emulsion or a cream.

[0054] The present invention also provides the use of the above skin care composition applied to the skin surface for non-therapeutic purposes to inhibit lipid peroxidation.

[0055] The present invention also provides application of the skin care composition in inhibiting lipid peroxidation.

[0056] The present invention also provides application of the skin care composition in preparing products for inhibiting lipid peroxidation.

[0057] The skin care composition is used for one or more of repairing skin barrier, improving skin dryness and reducing skin sensitivity.

[0058] The lipids of the present invention include oils and fats containing unsaturated bonds, and the oils and fats containing unsaturated bonds are easily oxidized.

[0059] The present invention also provides application of the skin care composition in anti-oxidation.

[0060] The present invention also provides application of the skin care composition in preparing anti-oxidation products.

[0061] The present invention also provides application of the skin care composition in preparing cosmetics.

[0062] The skin care composition of the present application can exert a synergistic anti-lipid oxidation effect in a variety of formulation systems by compounding bakuchiol and rosmarinic acid. On the one hand, it broadens the application scenarios of the compound; on the other hand, it solves the problem that water-soluble antioxidants and oil-soluble antioxidants cannot exert a synergistic effect in an emulsified system, thereby improving the anti-lipid oxidation efficacy of the emulsified system product and increasing the selectivity of the dosage form and active ingredients of the anti-lipid oxidation product.

[0063] Test Example 1

[0064] 1. Test methods

[0065] 1.1 Method Overview:

[0066] Using homemade artificial sebum as an experimental model, adding different concentrations of antioxidant compositions, and sequentially inducing by smoke and ultraviolet irradiation, the artificial sebum produced sufficient malondialdehyde, and the content of malondialdehyde was detected. The inhibition rate of the antioxidant composition was calculated by the reduction of malondialdehyde, thereby evaluating the anti-lipid peroxidation ability of the antioxidant composition.

[0067] 1.2 Preparation of artificial sebum:

[0068] Weigh 5 g of triolein, 2.5 g of myristyl myristate (myristate), 1 g of oleic acid and 0.1 g of cholesterol, put them in a beaker, heat and stir until all solids are dissolved into a uniform oily liquid, add 1.2 g of squalene, stir evenly, and cool to obtain simulated artificial sebum.

[0069] 1.3 Preparation of experimental samples

[0070] (1) Preparation of experimental samples 1-16

[0071] a. Dissolve bakuchiol in anhydrous ethanol and mix well to obtain sample 1 with a concentration of 0.05wt%.

[0072] b. Dissolve rosmarinic acid in anhydrous ethanol and mix well to obtain sample 2 with a concentration of 0.05wt%.

[0073] c. 0.05% ethanol solution of bakuchiol and 0.05% ethanol solution of rosmarinic acid were mixed in volume ratios of 1:99, 1:70, 1:50, 1:20, 1:9, 1:4, 1:1.5, 1.5:1, 4:1, 9:1, 20:1, 50:1, 70:1, and 99:1 to obtain samples 3-16. The mass ratios of the active ingredients in experimental samples 1-16 are shown in Table 1 below.

[0074] Table 1

[0075] sample Mass ratio of bakuchiol to rosmarinic acid 1 - 2 - 3 1：99 4 1：70 5 1：50 6 1：20 7 1：9 8 1：4 9 1：1.5 10 1.5：1 11 4：1 12 9：1 13 20：1 14 50：1 15 70：1 16 99：1

[0076] (2) Preparation of experimental samples 17-18

[0077] a. Dissolve thioneine in anhydrous ethanol and mix well to obtain a sample 17 having a concentration of 0.05wt%.

[0078] b. 0.05% ethanol solution of bakuchiol and 0.05% ethanol solution of ergothioneine were mixed in a volume ratio of 1:1.5 to obtain sample 18.

[0079] The mass ratios of the active ingredients in the experimental samples 17-18 are shown in Table 2 below.

[0080] Table 2

[0081] sample Quality Ratio 17 - 18 1：1.5

[0082] 1.4 Smear

[0083] 1.4.1 Take about 10 mg of artificial sebum and spread it evenly on the D-Squame membrane to form a thin oil film to make an artificial sebum smear.

[0084] 1.4.2 Use a pipette to accurately measure 20 μL of each experimental sample solution prepared above and evenly apply it on the artificial sebum smear. Repeat 6 pieces for each sample; at the same time, take 6 smears without adding experimental sample solution as blank controls.

[0085] 1.5 Smoke induction and UV irradiation experiments

[0086] 1.5.1 Design of smoke simulation device: Make a homemade cigarette smoke box, open a hole near the bottom of the box and fix it with a two-way pipe. Fix the cigarette at one end of the two-way pipe to ensure it is suspended in the air, and the other end leads to the outside of the box. Place a mesh partition at half the height of the box and place the smear on the mesh partition. After the experiment starts, seal the box to prevent smoke from leaking out.

[0087] 1.5.2 Place the smear without the experimental sample solution (blank control) and the artificial sebum smear with the experimental sample solution into the smoke simulation device, light a cigarette, and keep it sealed for 25 minutes. After the end, take out the smears and place them in the sunlight simulation irradiator for 15 minutes. The UV energy is set to 0.45J / cm 2 , take it out after completion, and the lipid oxidation reaction of sebum is completed.

[0088] 1.6 Sample pretreatment and derivatization

[0089] The artificial sebum smear after the lipid oxidation reaction was placed in a 2 mL centrifuge tube, 1 mL of trichloroacetic acid mixed solution was accurately added, vortexed and mixed, placed in a constant temperature ultrasonic cleaner at 50°C for 30 min, taken out, and cooled to room temperature to obtain an extract.

[0090] According to the method in GB 5009.181-2016 "Determination of malondialdehyde in food - Method 1", a malondialdehyde standard curve series was prepared using a trichloroacetic acid mixed solution.

[0091] Take 0.5mL of the extract and the MDA standard curve series, place them in 2mL centrifuge tubes, add 0.5mL of thiobarbituric acid aqueous solution, add stopper, mix well, place in a 90℃ water bath to react for 30min, take out, cool to room temperature, take the supernatant through a 0.22μm filter membrane and perform liquid chromatography analysis. At the same time, use a trichloroacetic acid mixed solution as a solvent blank.

[0092] Among them, the preparation method of the above-mentioned trichloroacetic acid mixed solution and thiobarbituric acid aqueous solution and the liquid chromatography detection method of malondialdehyde are carried out with reference to the method described in GB 5009.181-2016 Determination of malondialdehyde in food, method 1.

[0093] 1.7 Evaluation method of anti-lipid oxidation effect

[0094] An inhibition rate (IC) ≥ 25% is considered to have significant anti-lipid oxidation efficacy. The inhibition rate is calculated as follows:

[0095] IC=(V0-V1) / V0*100

[0096] Where, IC——MDA inhibition rate after adding experimental samples, %;

[0097] V0——the malondialdehyde content of blank sebum without adding experimental samples after induction experiment, ug / L;

[0098] V1——The malondialdehyde content obtained after the induction experiment of the sebum with added experimental samples, ug / L.

[0099] 1.8 Data Statistics and Synergy Evaluation Criteria

[0100] The MDA inhibition rate of each experimental sample was determined according to the formula suggested by Dai Tijun in the literature "Quantitative Analysis of Combined Drug Use": A+B (i.e., MDA inhibition rate) and the effect of a single component E A or E B (i.e., MDA inhibition rate) were compared and statistically processed (T test). A+B Greater than E A or E B , and P < 0.05, it can be considered that component A and component B are synergistic; if E A+B Less than E A or E B , and P < 0.05, it can be considered that component A and component B are antagonistic; if P > 0.05, it can be determined that component A and component B are additive.

[0101] In Table 3, p1 is the effect E of the composition No. 3-16 and No. 18 A+B Effect E with Bakuchiol (Sample 1) A The statistical comparison results, p2 is the effect E of the combination No. 3-16 and No. 18 A+B Effect E with rosmarinic acid (sample 2) or ergothioneine (sample 17) B Statistical comparison results.

[0102] 2. Results of the anti-lipid oxidation test of each experimental sample

[0103] The experimental comparison is carried out according to the evaluation method given in the experiment, and the results are shown in Table 3 below.

[0104] From the data in Table 3, it can be seen that the MDA inhibition rate of the combination of bakuchiol and rosmarinic acid is significantly higher than that of a single substance, indicating that the combination of bakuchiol and rosmarinic acid produces a synergistic anti-lipid oxidation effect.

[0105] Table 3

[0106]

[0107]

[0108] Test Example 2 Antioxidant Effect of Emulsified System Containing Combination of Bakuchiol and Rosmarinic Acid

[0109] 1. Experimental sample preparation

[0110] Sample 19: 0.5 g of bakuchiol was dissolved in 1 g of PEG-400 hydrogenated castor oil, water was added, and the mixture was stirred to dissolve to prepare an emulsion with a volume of 100 mL. The emulsion was diluted 10 times with ethanol to obtain an emulsion system containing 0.05% bakuchiol.

[0111] Sample 20: 0.5 g of rosmarinic acid was dissolved in water to prepare a solution with a volume of 100 mL. The solution was diluted 10 times with ethanol to obtain a solution containing 0.05% rosmarinic acid.

[0112] Sample 21: 0.1 g of bakuchiol was dissolved in 1 g of PEG-400 hydrogenated castor oil, 0.4 g of rosmarinic acid was added, water was added, and the mixture was stirred to dissolve to prepare an emulsion with a volume of 100 mL. The emulsion was diluted 10 times with ethanol to obtain an emulsion system containing a combination of bakuchiol and rosmarinic acid.

[0113] 2. According to the method described in Experimental Example 1, the self-made artificial sebum was used as the experimental model to verify the anti-lipid oxidation effect of each experimental sample. The results are shown in Table 4 below.

[0114] It can be seen from the data in Table 4 that the MDA inhibition rate of bakuchiol and rosmarinic acid in the emulsified system is also significantly higher than that of a single substance, indicating that the combination of bakuchiol and rosmarinic acid in the emulsified system also produces a synergistic anti-lipid oxidation effect.

[0115] Table 4

[0116]

[0117]

[0118] Test Example 3 Antioxidant effect of an oil containing a combination of bakuchiol and rosmarinic acid

[0119] 1. Experimental sample preparation

[0120] Sample 22: Take 0.02 g of bakuchiol and dissolve it in 100 g of caprylic acid / capric acid triglyceride to prepare a bakuchiol oil solution with a concentration of 0.02 wt%.

[0121] Sample 23: 0.02 g of rosmarinic acid was dissolved in 100 g of caprylic acid / capric acid triglyceride by heating at 45° C. to prepare a rosmarinic acid oil solution with a concentration of 0.02 wt %.

[0122] Sample 24: The above-mentioned 0.02 wt % rosmarinic acid oil solution and 0.02 wt % bakuchiol oil solution were mixed in a volume ratio of 1:1 to obtain an oil preparation containing bakuchiol and rosmarinic acid.

[0123] 2. According to the method described in Experimental Example 1, the self-made artificial sebum was used as the experimental model to verify the anti-lipid oxidation effect of each experimental sample. The results are shown in Table 5 below.

[0124] It can be seen from the data in Table 5 that the MDA inhibition rate of bakuchiol and rosmarinic acid in the oil is also significantly higher than that of a single substance, indicating that the combination of bakuchiol and rosmarinic acid in the oil also produces a synergistic anti-lipid oxidation effect.

[0125] Table 5

[0126] Experimental samples Quality Ratio Malondialdehyde inhibition rate / % p1 p2 Effect Sample 22 - 17.15±3.55 - - - Sample 23 - 16.18±3.38 - - - Sample 24 1:1 31.80±4.21 0.004 0.025 Collaboration

Claims

1. A skin care composition, characterized in that: The physiologically acceptable medium comprises bakuchiol and rosmarinic acid, wherein the mass ratio of bakuchiol to rosmarinic acid is 1:5 to 5:

1.

2. The skin care composition according to claim 1, characterized in that: The composition also includes an oily component.

3. The skin care composition according to claim 1 or 2, characterized in that: The composition is prepared into one or more of an oil, an emulsion, and a cream.

4. Use of the skin care composition according to any one of claims 1 to 3 for non-therapeutic purposes on the skin surface to inhibit lipid peroxidation.

5. Use of the skin care composition according to any one of claims 1 to 3 in preparing a product for inhibiting lipid peroxidation.

6. The use according to claim 4 or 5, wherein the skin care composition is used for one or more of repairing the skin barrier, improving skin dryness, and reducing skin sensitivity.

7. The use according to any one of claims 4 to 6, characterized in that: The lipids include oils and fats containing unsaturated bonds.

8. Use of the skin care composition according to any one of claims 1 to 3 in anti-oxidation.

9. Use of the skin care composition according to any one of claims 1 to 3 in the preparation of antioxidant products.

10. Use of the skin care composition according to any one of claims 1 to 3 in the preparation of cosmetics.

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