A sublingual thrombolytic and hemostatic drug formula and preparation method thereof

Abstract

The invention discloses a sublingual thrombolytic and hemostatic drug formula and a preparation method thereof. The formula is composed of the following raw materials in parts by weight: 10-15 parts of ginseng, 10-15 parts of poria cocos, 8-10 parts of longan, 8-10 parts of leek, 5-10 parts of aloe, 5-10 parts of angelica, 10-15 parts of plantain seeds, 5-10 parts of carrots, 5-10 parts of astragalus, 5-10 parts of salvia miltiorrhiza, 5-7 parts of notoginseng, 5-7 parts of wolfberry, 5-7 parts of cinnamon bark, and 5-20 parts of honeysuckle. The ingredients work synergistically. Ginseng, Astragalus, etc. can replenish Qi and promote blood circulation; Salvia miltiorrhiza and Panax notoginseng can promote blood circulation and remove blood stasis; Poria cocos can strengthen the spleen and eliminate dampness, which helps the circulation of Qi and blood; Longan and Lycium barbarum can nourish Qi and blood; Angelica sinensis can nourish blood and promote blood circulation; Leek can warm the Yang and promote blood circulation; Aloe vera can clear away heat and remove blood stasis; Plantago can promote diuresis and remove dampness; Carrots are rich in nutrients to help body functions; Cinnamon can warm and circulate blood; Honeysuckle can clear away heat and detoxify, prevent endogenous heat evil from affecting the efficacy of the medicine and avoid thrombotic inflammatory reactions.

Description

Technical Field

[0001] The present invention relates to the technical field of traditional Chinese medicine, and more particularly to a sublingual thrombolytic and hemostatic drug formula and a preparation method thereof. Background Art

[0002] At present, cardiovascular and cerebrovascular diseases such as thrombosis seriously threaten human health, and existing thrombolytic drugs may have serious side effects and high prices. At the same time, in some bleeding situations, safe and effective hemostatic methods are also needed. Traditional Chinese medicine has unique advantages and rich experience in regulating human physiological functions and preventing and treating diseases. Therefore, the development of a sublingual thrombolytic and hemostatic formula based on traditional Chinese medicine has important practical significance and market prospects. Summary of the invention

[0003] In view of this, the present invention aims to provide a Chinese medicine formula that can effectively achieve sublingual thrombolysis and has hemostatic function and a preparation method thereof, so as to solve related health problems in a safe, efficient and low-cost manner, improve the quality of life of patients, and fill the gap of such Chinese medicine formulas on the market.

[0004] To achieve the above purpose, the present invention provides the following technical scheme, which is composed of the following raw materials in parts by weight: 10-15 parts of ginseng, 10-15 parts of poria cocos, 8-10 parts of longan, 8-10 parts of leek, 5-10 parts of aloe, 5-10 parts of angelica, 10-15 parts of plantain seeds, 5-10 parts of carrots, 5-10 parts of astragalus, 5-10 parts of salvia miltiorrhiza, 5-7 parts of Panax notoginseng, 5-7 parts of wolfberry, 5-7 parts of cinnamon, and 5-20 parts of honeysuckle.

[0005] Preferably, in the above-mentioned sublingual thrombolytic and hemostatic drug formulation and preparation method thereof, the formulation is prepared in the form of a sublingual tablet or a liquid.

[0006] Preferably, the above-mentioned sublingual thrombolytic and hemostatic drug formulation and preparation method thereof include the following steps:

[0007] Raw material pretreatment: wash and dry ginseng, poria, angelica, astragalus, salvia miltiorrhiza, Panax notoginseng, and cinnamon bark, grind them into fine powder, and pass through an 80-100 mesh sieve; remove the core of longan and take out the flesh, dry it, and grind it; wash leek, aloe vera, and carrot, squeeze the juice for later use; wash plantain and honeysuckle, add water and boil for 1-2 hours, and filter the juice;

[0008] Mixing and granulation: Evenly mix the above-treated powder, juice and decoction, add appropriate amount of auxiliary materials to make a soft material, granulate through a 14-18 mesh sieve, and dry the granules at 40-60°C to a moisture content of 3-5%;

[0009] Tablet molding: Add an appropriate amount of lubricant to the dried granules and mix evenly, then use a tablet press to press them into sublingual tablets, each weighing 0.3-0.5g.

[0010] Preferably, in the above-mentioned sublingual thrombolytic and hemostatic drug formulation and preparation method thereof, the

[0011] It can be seen from the above technical scheme that compared with the prior art, the present invention discloses a sublingual thrombolytic and hemostatic drug formula and a preparation method thereof. The raw materials act synergistically. Ginseng, Astragalus, etc. can replenish qi and promote blood circulation; Salvia miltiorrhiza and Panax notoginseng can promote blood circulation and remove blood stasis; Poria can strengthen the spleen and eliminate dampness and help qi and blood circulation; Longan and Lycium barbarum can nourish qi and blood; Angelica sinensis can nourish blood and promote blood circulation; Leek can warm the yang and promote blood circulation; Aloe can clear away heat and remove blood stasis; Plantago can promote diuresis and remove dampness; Carrots are rich in nutrients to help body functions; cinnamon can warm and circulate blood; Honeysuckle can clear away heat and detoxify to prevent endogenous heat evil from affecting the efficacy of the drug and avoid thrombotic inflammatory reactions. DETAILED DESCRIPTION

[0012] The following will be combined with the embodiments of the present invention to clearly and completely describe the technical solutions in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, not all of the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0013] The invention is composed of the following raw materials in parts by weight: 10-15 parts of ginseng, 10-15 parts of poria, 8-10 parts of longan, 8-10 parts of leek, 5-10 parts of aloe, 5-10 parts of angelica, 10-15 parts of plantain seeds, 5-10 parts of carrots, 5-10 parts of astragalus, 5-10 parts of salvia miltiorrhiza, 5-7 parts of notoginseng, 5-7 parts of wolfberry, 5-7 parts of cinnamon and 5-20 parts of honeysuckle.

[0014] It should be noted that the raw materials work synergistically. Ginseng, Astragalus, etc. can replenish Qi and promote blood circulation; Salvia miltiorrhiza and Panax notoginseng can promote blood circulation and remove blood stasis; Poria cocos can strengthen the spleen and eliminate dampness, and aid the circulation of Qi and blood; Longan and Lycium barbarum can nourish Qi and blood; Angelica sinensis can nourish blood and promote blood circulation; Leek can warm the Yang and promote blood circulation; Aloe vera can clear away heat and remove blood stasis; Plantago can promote diuresis and remove dampness; Carrots are rich in nutrients to help body functions; Cinnamon can warm and circulate blood; Honeysuckle can clear away heat and detoxify, prevent endogenous heat evil from affecting the efficacy of the medicine and avoid thrombotic inflammatory reactions.

[0015] It should be noted that the dosage form is selected as a sublingual tablet. Sublingual tablets can allow the drug to be quickly absorbed into the blood circulation through the sublingual mucosa, avoid the first-pass effect of the liver, improve the bioavailability of the drug, and quickly exert thrombolytic and hemostatic effects, which is especially suitable for thrombosis prevention and bleeding control in emergency situations.

[0016] In order to further optimize the above technical solution, the preparation method

[0017] 1. Raw material pretreatment: wash and dry ginseng, poria, angelica, astragalus, salvia miltiorrhiza, Panax notoginseng and cinnamon, grind them into fine powder, and pass through 80-100 mesh sieve; remove the core of longan, take out the pulp, dry it and grind it; wash leek, aloe vera and carrot, squeeze the juice for later use; wash plantain seed and honeysuckle, add water and boil for 1-2 hours, filter and take the juice.

[0018] 2. Mixing and granulation: Evenly mix the above-treated powder, juice and decoction, add appropriate amount of auxiliary materials (such as mannitol, magnesium stearate, etc.) to make a soft material, granulate through a 14-18 mesh sieve, and dry the granules at 40-60°C to a moisture content of 3-5%.

[0019] 3. Tablet molding: Add an appropriate amount of lubricant (such as talcum powder) to the dried granules, mix evenly, and use a tablet press to press them into sublingual tablets, each weighing 0.3-0.5g.

[0020] Usage and efficacy verification

[0021] 1. How to use

[0022] When used for sublingual thrombolysis prevention, take 1-2 tablets 1-2 times a day, sublingually until completely dissolved; in the case of acute bleeding, take 2-3 tablets immediately depending on the degree of bleeding to promote hemostasis.

[0023] 2. Efficacy verification

[0024] Through animal experiments, rats with thrombosis model and mice with bleeding model were selected, and the sublingual tablets of the present invention were respectively administered to observe the thrombus dissolution and the bleeding cessation time, and compared with the control group. The results showed that the formula of the present invention has significant effects in thrombolysis and hemostasis. At the same time, a certain number of clinical volunteers were selected to conduct preliminary human trial observations under the premise of complying with ethical norms, and the changes in coagulation indicators, hemorheology indicators, etc. before and after use were recorded to further verify its effectiveness and safety on the human body.

[0025] In this specification, each embodiment is described in a progressive manner, and each embodiment focuses on the differences from other embodiments. The same or similar parts between the embodiments can be referred to each other. For the device disclosed in the embodiment, since it corresponds to the method disclosed in the embodiment, the description is relatively simple, and the relevant parts can be referred to the method part.

[0026] The above description of the disclosed embodiments enables one skilled in the art to implement or use the present invention. Various modifications to these embodiments will be apparent to one skilled in the art, and the general principles defined herein may be implemented in other embodiments without departing from the spirit or scope of the present invention. Therefore, the present invention will not be limited to the embodiments shown herein, but rather to the widest scope consistent with the principles and novel features disclosed herein.

Claims

1. A sublingual thrombolytic and hemostatic drug formulation, characterized in that: The invention is composed of the following raw materials in parts by weight: 10-15 parts of ginseng, 10-15 parts of poria cocos, 8-10 parts of longan, 8-10 parts of leek, 5-10 parts of aloe, 5-10 parts of angelica, 10-15 parts of plantain seeds, 5-10 parts of carrots, 5-10 parts of astragalus, 5-10 parts of salvia miltiorrhiza, 5-7 parts of Panax notoginseng, 5-7 parts of wolfberry, 5-7 parts of cinnamon bark and 5-20 parts of honeysuckle.

2. A sublingual thrombolytic and hemostatic drug formulation according to claim 1, characterized in that: The formulation is prepared in the form of a sublingual tablet or a liquid.

3. A method for preparing a sublingual thrombolytic and hemostatic drug formulation according to claim 1, characterized in that: The following steps are involved: Raw material pretreatment: wash and dry ginseng, poria, angelica, astragalus, salvia miltiorrhiza, Panax notoginseng, and cinnamon bark, grind them into fine powder, and pass through an 80-100 mesh sieve; remove the core of longan and take out the flesh, dry it, and grind it; wash leek, aloe vera, and carrot, squeeze the juice for later use; wash plantain and honeysuckle, add water and boil for 1-2 hours, and filter the juice; Mixing granulation: mix the above-treated powder, juice and decoction evenly, add appropriate amount of auxiliary materials to make a soft material, granulate through a 14-18 mesh sieve, and dry the granules at 40-60°C to a moisture content of 3-5%; tableting: add appropriate amount of lubricant to the dried granules and mix evenly, then use a tablet press to press into sublingual tablets, each weighing 0.3-0.5g.