Antibacterial and antiviral ointment for verruca plantaris and preparation method thereof

Abstract

The invention discloses an antibacterial and antiviral ointment for verruca plantaris and a preparation method of the antibacterial and antiviral ointment, and relates to the technical field of traditional Chinese medicines. The traditional Chinese medicine composition is prepared from the following components: 0.5 to 1.5 parts of purpurea sal ammoniac, 0.4 to 1.2 parts of calculus bovis factitius, 0.8 to 2 parts of pearl powder, 0.8 to 1.5 parts of realgar, 0.5 to 1 part of venenum bufonis, 0.5 to 1 part of borneol, 0.5 to 1 part of sulfur, 0.5 to 1 part of collagen peptide, 1 to 2 parts of matrix vaseline, 1 to 2 parts of wool fat and 0.5 to 1 part of liquid paraffin. The ointment is mainly used for treating ulcers, furunculosis and collagen peptide, cells at pathological positions can be repaired, immunity can be improved, according to a preparation method of the ointment, firstly, sal ammoniac, calculus bovis factitius, pearl powder, realgar, venenum bufonis and sulfur are dissolved in borneol, pharmacology is improved, then the collagen peptide, matrix vaseline, wool fat and liquid paraffin are added, and the ointment is prepared. When the medicinal materials are prepared into paste, the skin repairing function can be achieved.

Description

Technical Field

[0001] The invention relates to the technical field of traditional Chinese medicines, and in particular to an antibacterial and antiviral ointment for plantar warts and a preparation method thereof. Background Art

[0002] Plantar warts are caused by human papillomavirus infection and occur on one or both sides of the sole, especially common warts on the front of the sole. Patients may feel tenderness when walking. The number of skin lesions varies, often only 1 to 2, or there may be many scattered all over the sole, or densely distributed. In clinical practice, doctors will take appropriate medication or surgical treatment according to the actual situation of the patient.

[0003] At present, there is no very targeted Chinese medicine prescription for the treatment of plantar warts, and multiple plantar warts are still difficult to treat clinically, so it is imperative to develop an antibacterial and antiviral ointment for plantar warts. Summary of the invention

[0004] In order to overcome the above-mentioned shortcomings, the present invention provides an antibacterial and antiviral ointment for plantar warts and a preparation method thereof.

[0005] The present invention achieves the above-mentioned purpose through the following technical solutions:

[0006] An antibacterial and antiviral ointment for plantar warts consists of the following components by weight: 0.5-1.5 parts of purple borax, 0.4-1.2 parts of artificial bezoar, 0.8-2 parts of pearl powder, 0.8-1.5 parts of realgar, 0.5-1 part of toad venom, 0.5-1 part of borneol, 0.5-1 part of sulfur, 0.5-1 part of collagen peptide, 1-2 parts of base vaseline, 1-2 parts of lanolin and 0.5-1 part of liquid paraffin.

[0007] Preferably, the preparation comprises the following components by weight: 1 part of purple alumina, 0.8 parts of artificial bezoar, 1.0 parts of pearl powder, 1.1 parts of realgar, 0.6 parts of toad venom, 0.7 parts of borneol, 0.7 parts of sulfur, 0.7 parts of collagen peptide, 1.3 parts of base vaseline, 1.4 parts of lanolin and 0.8 parts of liquid paraffin.

[0008] Preferably, the preparation comprises the following components in parts by weight: 0.8 parts of purple alumina, 1.1 parts of artificial bezoar, 1.2 parts of pearl powder, 1.1 parts of realgar, 0.6 parts of toad venom, 0.6 parts of borneol, 0.6 parts of sulfur, 0.6 parts of collagen peptide, 1.2 parts of base vaseline, 1.2 parts of lanolin and 0.8 parts of liquid paraffin.

[0009] Preferably, the preparation comprises the following components in parts by weight: 1.5 parts of purple alumina, 1.1 parts of artificial bezoar, 1.6 parts of pearl powder, 1.1 parts of realgar, 0.6 parts of toad venom, 0.6 parts of borneol, 0.6 parts of sulfur, 1.0 parts of collagen peptide, 1.2 parts of base vaseline, 1.2 parts of lanolin and 0.8 parts of liquid paraffin.

[0010] An antibacterial and antiviral ointment for plantar warts as described above is also disclosed, and a method for preparing the ointment is also disclosed, comprising the following steps:

[0011] Step 1: Take the medicinal materials according to the proportion, grind them into powder, and then heat them to 30-50℃, borneol begins to melt, and purple alumina, artificial bezoar, pearl powder, realgar, toad venom and sulfur will dissolve in it. The medicinal materials are purple alumina, artificial bezoar, pearl powder, realgar, toad venom, borneol and sulfur;

[0012] Step 2: When the temperature returns to 30°C and the medicinal materials are still in liquid form, pour in other medicinal materials and stir. The medicinal materials poured in are collagen peptide, matrix vaseline, lanolin and liquid paraffin;

[0013] Step 3: The temperature returns to normal.

[0014] Preferably, in step one, in order to speed up the dissolution efficiency, a proper amount of solvent water may be added, and in this case, in step two, the water needs to be evaporated at a low temperature.

[0015] The invention has the beneficial effects that: in the antibacterial and antiviral ointment for plantar warts and the preparation method thereof, purple borax has the purpose of relieving pain and treating malignant sores and warts, toad venom has the effects of detoxification, relieving pain, invigorating the mind and invigorating the mind, and is mainly used to treat carbuncles and furuncles, and collagen peptide can not only repair cells at the pathological site, but also improve immunity. In the preparation method of the ointment, borax, artificial bezoar, pearl powder, realgar, toad venom and sulfur are firstly dissolved in the ointment by borneol to improve the pharmacology, and then collagen peptide, matrix vaseline, lanolin and liquid paraffin are added to make the medicinal materials into a paste, and the ointment can have the function of skin repairing. DETAILED DESCRIPTION

[0016] The present invention will now be described in further detail.

[0017] An antibacterial and antiviral ointment for plantar warts consists of the following components by weight: 0.5-1.5 parts of purple borax, 0.4-1.2 parts of artificial bezoar, 0.8-2 parts of pearl powder, 0.8-1.5 parts of realgar, 0.5-1 part of toad venom, 0.5-1 part of borneol, 0.5-1 part of sulfur, 0.5-1 part of collagen peptide, 1-2 parts of base vaseline, 1-2 parts of lanolin and 0.5-1 part of liquid paraffin.

[0018] An antibacterial and antiviral ointment for plantar warts as described above is also disclosed, and a method for preparing the ointment is also disclosed, comprising the following steps:

[0019] Step 1: Take the medicinal materials according to the proportion, grind them into powder, and then heat them to 30-50℃, borneol begins to melt, and purple alumina, artificial bezoar, pearl powder, realgar, toad venom and sulfur will dissolve in it. The medicinal materials are purple alumina, artificial bezoar, pearl powder, realgar, toad venom, borneol and sulfur;

[0020] Step 2: When the temperature returns to 30°C and the medicinal materials are still in liquid form, pour in other medicinal materials and stir. The medicinal materials poured in are collagen peptide, matrix vaseline, lanolin and liquid paraffin;

[0021] Step 3: The temperature returns to normal.

[0022] Among them, in step one, in order to speed up the dissolution efficiency, an appropriate amount of solvent water can be added. At this time, in step two, it is necessary to evaporate the water at a low temperature.

[0023] Purple borax can remove badaganheyi, regulate stomach fire, relieve constipation, relieve pain, and is used to treat malignant sores and warts;

[0024] Collagen peptides are a type of extracellular protein extracted from fresh tissues such as animal skin, tendons, tendons and scales. They can beautify the skin and improve immunity. In this patent, they can not only repair cells in pathological areas, but also improve immunity.

[0025] Matrix vaseline: After the medicinal materials in step one are ground and dissolved, the matrix vaseline is used to dissolve the remaining medicinal materials into an ointment for easy use.

[0026] Example 1 is composed of the following components, by weight: 1 part of purple alumina, 0.8 part of artificial bezoar, 1.0 part of pearl powder, 1.1 part of realgar, 0.6 part of toad venom, 0.7 part of borneol, 0.7 part of sulfur, 0.7 part of collagen peptide, 1.3 parts of base vaseline, 1.4 parts of lanolin and 0.8 part of liquid paraffin.

[0027] Example 2 is composed of the following components, by weight: 0.8 parts of purple alumina, 1.1 parts of artificial bezoar, 1.2 parts of pearl powder, 1.1 parts of realgar, 0.6 parts of toad venom, 0.6 parts of borneol, 0.6 parts of sulfur, 0.6 parts of collagen peptide, 1.2 parts of base vaseline, 1.2 parts of lanolin and 0.8 parts of liquid paraffin.

[0028] Example 3 is composed of the following components, by weight: 1.5 parts of purple alumina, 1.1 parts of artificial bezoar, 1.6 parts of pearl powder, 1.1 parts of realgar, 0.6 parts of toad venom, 0.6 parts of borneol, 0.6 parts of sulfur, 1.0 parts of collagen peptide, 1.2 parts of base vaseline, 1.2 parts of lanolin and 0.8 parts of liquid paraffin.

[0029] Test verification:

[0030] From January 2019 to December 2023, 302 patients with plantar warts who visited the Shenyang Military Region General Hospital were selected and divided into 3 groups, with 100 cases in each group;

[0031] Diagnostic criteria: Based on patent number CN1 16392566A, patent name: A Chinese medicine composition for treating multiple plantar warts and its application, hereinafter collectively referred to as reference patents. The diagnostic criteria cited in the reference patents are as follows:

[0032] Refer to the diagnostic criteria for plantar warts in the book "Dermatology of Integrated Traditional Chinese and Western Medicine" edited by Li Bin and Chen Dacan and the "Standards for Diagnosis and Efficacy of TCM Diseases". The diagnosis is based on the main symptoms: initially, it is a small keratinous papule, which gradually increases in size and may also merge into a piece, with a grayish yellow or grayish white color, a rough surface, and a slight concave center. The pain increases with pressure, or there may be no symptoms. After removing the stratum corneum of some plantar warts, there is a loose keratin soft core underneath, and small black spots formed by ruptured capillaries and bleeding can be seen.

[0033] Inclusion criteria

[0034] ①Meet the above diagnostic criteria for plantar warts;

[0035] ②The number of warts is ≥10;

[0036] ③Age 18 to 60, regardless of gender;

[0037] ④The patient is unwilling to accept cryotherapy or laser treatment;

[0038] ⑤Sign the informed consent and be able to adhere to the follow-up for 6 months.

[0039] Exclusion criteria

[0040] ① Those who are allergic to the drugs in this clinical trial;

[0041] ② Those with scar tissue or local skin ulceration and erosion;

[0042] ③ Pregnant and lactating women;

[0043] ④ Have other serious systemic diseases.

[0044] Rejection and shedding criteria

[0045] ① Those with poor compliance, who fail to return for follow-up visits on time or fail to take medication as prescribed by the doctor;

[0046] ② The use of other treatment methods during treatment or follow-up that may affect the efficacy observation;

[0047] ③ Those with serious adverse reactions.

[0048] Efficacy evaluation criteria

[0049] The clinical symptom score was the sum of the wart number score, wart area score and pain severity score.

[0050] Scoring is based on the following criteria:

[0051] ① Score for the number of warts: 0, 0 points; 1-5, 2 points; 6-10, 3 points; 11-15, 4 points; >15, 5 points.

[0052] ② Wart size score (calculated based on the maximum diameter of the wart): no skin lesions, 0 points; <5 mm, 1 point; 5-10 mm (including 5 mm), 2 points; 10-15 mm (including 10 mm), 3 points; 15-20 mm (including 15 mm), 4 points; ≥20 mm, 5 points.

[0053] ③ Pain severity score: The numerical rating scale (NRS) was used for scoring. No pain was recorded as 0 points; pain when pressing hard and slight pain when walking was recorded as 1 point; mild pain when touching but not affecting life was recorded as 2 points; moderate pain when touching but still tolerable was recorded as 3 points; severe pain when touching but unbearable was recorded as 4 points. The symptom scores of each group before and after treatment were recorded and counted.

[0054] The clinical efficacy of multiple plantar warts refers to the efficacy determination criteria for palmoplantar warts in the "Diagnosis and Efficacy Standards for Traditional Chinese Medicine Diseases".

[0055] ① Cured: All warts fall off, no new warts appear, and the efficacy index is ≥90%;

[0056] ② Significantly effective: Most of the warts fall off, no new warts appear, 70%≤efficacy index<90%;

[0057] ③ Effective: Warts fall off by more than 30% compared with before treatment, symptoms are relieved, 30%≤efficacy index<70%;

[0058] ④ Ineffective: less than 30% of the warts fall off or new warts appear, and the efficacy index is less than 30%.

[0059] Efficacy index = (clinical symptom score before treatment - clinical symptom score after treatment) / clinical symptom score before treatment × 100%;

[0060] Total effective rate = (number of cured cases + number of markedly effective cases + number of effective cases) / total number of cases × 100%.

[0061] Experimental results:

[0062] The therapeutic effects of each experimental group are shown in the following table. The Chinese medicine composition of the present invention can effectively treat multiple plantar warts, and the total effective rate can reach 98%.

[0063] Group Example total get well Significant effect efficient invalid Total Effectiveness 1 Example 1 100 85 8 5 2 98％ 2 Example 2 100 80 10 5 5 95％ 3 Example 3 100 83 9 4 4 96％

[0064] The total effective rate is almost the same as that of the reference patent, but the skin recovery effect is still good. According to the experimental results, it can be known that the effect is best when 1.0 part of purple sand is used, and the patient's skin recovery effect is best when 1.0 part of collagen peptide is used. In summary, the combination of medicinal materials can be adjusted according to the patient's clinical symptoms.

[0065] The above is based on the present invention as an inspiration. Through the above description, relevant staff can make various changes and modifications without departing from the technical idea of ​​this invention. The technical scope of this invention is not limited to the content in the specification, and its technical scope must be determined according to the scope of the claims.

Claims

1. An antibacterial and antiviral ointment for plantar warts, characterized in that: The invention is composed of the following components by weight: 0.5-1.5 parts of purple alumina, 0.4-1.2 parts of artificial bezoar, 0.8-2 parts of pearl powder, 0.8-1.5 parts of realgar, 0.5-1 parts of toad venom, 0.5-1 parts of borneol, 0.5-1 parts of sulfur, 0.5-1 parts of collagen peptide, 1-2 parts of base vaseline, 1-2 parts of lanolin and 0.5-1 parts of liquid paraffin.

2. The antibacterial and antiviral ointment for plantar warts according to claim 1, characterized in that: The composition is composed of the following components by weight: 1 part of purple alumina, 0.8 part of artificial bezoar, 1.0 part of pearl powder, 1.1 part of realgar, 0.6 part of toad venom, 0.7 part of borneol, 0.7 part of sulfur, 0.7 part of collagen peptide, 1.3 parts of base vaseline, 1.4 parts of lanolin and 0.8 part of liquid paraffin.

3. The antibacterial and antiviral ointment for plantar warts according to claim 1, characterized in that: The preparation is composed of the following components by weight: 0.8 parts of purple alumina, 1.1 parts of artificial bezoar, 1.2 parts of pearl powder, 1.1 parts of realgar, 0.6 parts of toad venom, 0.6 parts of borneol, 0.6 parts of sulfur, 0.6 parts of collagen peptide, 1.2 parts of base vaseline, 1.2 parts of lanolin and 0.8 parts of liquid paraffin.

4. The antibacterial and antiviral ointment for plantar warts according to claim 1, characterized in that: The preparation is composed of the following components by weight: 1.5 parts of purple alumina, 1.1 parts of artificial bezoar, 1.6 parts of pearl powder, 1.1 parts of realgar, 0.6 parts of toad venom, 0.6 parts of borneol, 0.6 parts of sulfur, 1.0 parts of collagen peptide, 1.2 parts of base vaseline, 1.2 parts of lanolin and 0.8 parts of liquid paraffin.

5. An antibacterial and antiviral ointment for plantar warts according to claim 1, and a method for preparing the ointment, characterized in that: The following steps are involved: Step 1: Take the medicinal materials according to the proportion, grind them into powder, and then heat them to 30-50℃, borneol begins to melt, and purple alumina, artificial bezoar, pearl powder, realgar, toad venom and sulfur will dissolve in it. The medicinal materials are purple alumina, artificial bezoar, pearl powder, realgar, toad venom, borneol and sulfur; Step 2: When the temperature returns to 30°C and the medicinal materials are still in liquid form, pour in other medicinal materials and stir. The medicinal materials poured in are collagen peptide, matrix vaseline, lanolin and liquid paraffin; Step 3: The temperature returns to normal.

6. The method for preparing the antibacterial and antiviral ointment for plantar warts according to claim 5, characterized in that: In step one, in order to speed up the dissolution efficiency, an appropriate amount of solvent water can be added. At this time, in step two, the water needs to be evaporated at a low temperature.