Pressure adaptive method and apparatus

Abstract

The application provides a pressure self-adaptive method and device. The method comprises the following steps: obtaining a first pressure after a flushing device is connected with a ventricular assist device, the first pressure being a flushing pipeline pressure when a pump assembly drives flushing liquid at a first flushing liquid flow rate; calculating a target flushing liquid flow rate flowing into the flushing pipeline according to the first pressure; and calculating a target pressure according to the target flushing liquid flow rate, so that an outlet pressure of the flushing pipeline is greater than a second pressure, the second pressure being an ambient pressure of the flushing pipeline. The application calculates a suitable flushing liquid flow rate according to the current detected flushing pipeline pressure, and then calculates the optimal flushing pipeline pressure according to the flushing liquid flow rate, so that the flushing liquid pressure output by the flushing pipeline is greater than the ambient pressure at any time, so that the pressure barrier between the blood and the motor in the ventricular assist device is kept in a stable state, and the safe operation of the ventricular assist device is ensured.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, and in particular to a pressure self-adaptive method and device. BACKGROUND

[0002] The ventricular assist system mainly includes an interventional ventricular assist device, a controller and a flushing device. The interventional ventricular assist device (Ventricular Assist Device, VAD) is mainly used for protection of high-risk percutaneous coronary intervention (PCI) surgery. The flushing device is used to maintain the pressure barrier between the blood and the motor. The pressure formed by the flushing liquid in the opposite direction of the blood flow isolates the blood from the motor and prevents the blood from entering the motor. However, the flushing device currently generally directly sets a fixed pressure and maintains the flushing device at the fixed pressure. However, when the blood pressure in the ventricular assist device changes, the flushing device cannot be adjusted in time, which affects the operation of the ventricular assist device. SUMMARY

[0003] The embodiments of the present application provide a pressure self-adaptive method and device, which can adaptively control the pressure in the flushing pipeline according to the environmental pressure, so that the pressure barrier between the blood in the ventricular assist device and the motor is kept in a stable state, thereby ensuring the safe operation of the ventricular assist device.

[0004] In a first aspect, the embodiments of the present application provide a pressure self-adaptive method, which comprises:

[0005] After the flushing device and the ventricular assist device are operated, a first pressure is obtained, the first pressure being the flushing pipeline pressure when the pump assembly drives the flushing liquid at a first flushing liquid flow rate;

[0006] A target flushing liquid flow rate flowing into the flushing pipeline is calculated according to the first pressure;

[0007] A target pressure is calculated according to the target flushing liquid flow rate, so that the outlet pressure of the flushing pipeline is greater than a second pressure, the second pressure being the environmental pressure of the flushing pipeline.

[0008] In a second aspect, the embodiments of the present application provide a control circuit of a flushing device, the flushing device comprising a flushing pipeline for conveying flushing liquid and a pump assembly for driving the flushing liquid to flow, the control circuit comprising one or more processors, the one or more processors being configured to:

[0009] After the flushing device and the ventricular assist device are operated, a first pressure is obtained, the first pressure being the flushing pipeline pressure when the pump assembly drives the flushing liquid at a first flushing liquid flow rate;

[0010] calculating a target flush fluid flow rate into the flush line according to the first pressure;

[0011] calculating a target pressure according to the target flush fluid flow rate, so that an outlet pressure of the flush line is greater than a second pressure, the second pressure being an ambient pressure of the flush line.

[0012] In a third aspect, an embodiment of the present application provides a ventricular assist system, comprising:

[0013] a ventricular assist device;

[0014] a flush device for providing flush fluid to the ventricular assist device, the flush device comprising a flush line for conveying the flush fluid and a pump assembly for driving a flow of the flush fluid;

[0015] a control circuit for controlling operations of the ventricular assist device and the pump assembly, the control circuit being configured to perform the steps in the method of the first aspect.

[0016] In a fourth aspect, an embodiment of the present application provides a medical device, comprising a processor, a memory, a communication interface, and one or more programs stored in the memory and configured to be executed by the processor, the program comprising instructions for performing some or all of the steps described in the method of the first aspect.

[0017] In a fifth aspect, an embodiment of the present application provides a computer-readable storage medium storing a computer program for electronic data exchange, wherein the computer program causes a computer to perform some or all of the steps described in the method of the first aspect.

[0018] In a sixth aspect, an embodiment of the present application provides a computer program product, wherein the above computer program product includes a non-transitory computer-readable storage medium storing a computer program, and the computer program is operable to cause a computer to perform some or all of the steps described in the method of the first aspect of the present application. The computer program product can be a software installation package.

[0019] The technical scheme provided in the application obtains a first pressure after the flushing device is connected with the ventricular assist device, the first pressure being a flushing pipeline pressure of the pump assembly when driving the flushing liquid at a first flushing liquid flow rate; calculates a target flushing liquid flow rate flowing into the flushing pipeline according to the first pressure; and calculates a target pressure according to the target flushing liquid flow rate, so that the outlet pressure of the flushing pipeline is greater than a second pressure, the second pressure being an ambient pressure of the flushing pipeline. The application calculates a suitable flushing liquid flow rate according to the currently detected flushing pipeline pressure, and then calculates an optimal flushing pipeline pressure according to the flushing liquid flow rate, so that the flushing liquid pressure output by the flushing pipeline is greater than the ambient pressure of the flushing pipeline in real time, so that the pressure barrier between the blood and the motor in the ventricular assist device is kept in a stable state, and the safe operation of the ventricular assist device is ensured. BRIEF DESCRIPTION OF DRAWINGS

[0020] In order to more clearly illustrate the technical solutions in the embodiments of the application, the following will briefly introduce the drawings needed to be used in the embodiments. Obviously, the drawings described in the following are some embodiments of the application, and other drawings can also be obtained by those skilled in the art without any creative effort.

[0021] Figure 1 is a schematic diagram of a ventricular assist system provided by an embodiment of the application;

[0022] Figure 2 is a structural schematic diagram of the flushing device when the pump door cover is closed, provided by an embodiment of the application;

[0023] Figure 3 is a structural schematic diagram of the flushing device when the pump door is omitted, provided by an embodiment of the application;

[0024] Figure 4 is a structural schematic diagram of the flushing pipeline and the pump door, provided by an embodiment of the application;

[0025] Figure 5 is a flow schematic diagram of a pressure self-adaptive method provided by an embodiment of the application;

[0026] Figure 6 is a structural schematic diagram of a medical device provided by an embodiment of the application. DETAILED DESCRIPTION

[0027] In order for those skilled in the art to better understand the technical solutions of the application, the technical solutions in the embodiments of the application will be described clearly and completely below with reference to the drawings in the embodiments of the application. Obviously, the described embodiments are only some of the embodiments of the application, rather than all the embodiments. Based on the description of the embodiments of the application, all other embodiments obtained by those skilled in the art without any creative effort are within the scope of protection of the application.

[0028] The terms "first", "second", and the like, in the description and in the claims of the present application and above drawings, are used to distinguish different objects, and are not used to describe a particular sequential order. Moreover, the terms "comprises", "comprising", and the like, and any variations thereof, are intended to cover a non-exclusive inclusion. For example, a process, method, article, or apparatus that comprises a list of steps or elements is not necessarily limited to the listed steps or elements, but can include additional steps or elements not expressly listed or inherent to such process, method, article, or apparatus.

[0029] Reference herein to "an embodiment" means that a particular feature, structure, or characteristic described in connection with the embodiment can be included in at least one embodiment of the application. The appearances of the phrase that in various places in the specification are not necessarily all referring to the same embodiment, nor are they necessarily mutually exclusive of one another. As will be apparent to those of ordinary skill in the art, embodiments described herein can be combined with other embodiments.

[0030] The medical device and the pump involved in the present application can be a ventricular assist device (VAD), such as an implantable ventricular assist device, an interventional ventricular assist device, etc. The ventricular assist device can include at least one blood pump, wherein the blood pump can be a centrifugal pump, an axial flow pump, a magnetic suspension pump, etc.

[0031] It should be noted that the term "proximal" or "proximally" in the present application refers to the end or side closer to the operator; "distal" or "distally" refers to the end or side farther away from the operator.

[0032] In the present application, as shown in Figure 1 The ventricular assist system includes a ventricular assist device 30, an external controller 10, and a flush device 10. The ventricular assist device 30 is implanted in the patient's body, crosses the aortic valve of the patient's heart, so that the proximal end of the ventricular assist device 30 is located in the aorta and the distal end of the ventricular assist device 30 is located in the left ventricle, thereby pumping blood in the left ventricle into the aorta through the ventricular assist device 30 to provide partial or full assistance to the heart circulatory system. The controller 20 and the flush device 10 are located outside the body, the controller 20 is used to realize the control and data display of the ventricular assist device 30 and the flush device 10, as well as the functions of fault detection alarm, data recording, etc. The flush device 10 is used to maintain the pressure barrier between the blood and the motor, by connecting the flush pipeline of the flush device 10 to the motor bearing in the ventricular assist device 30, using the fluid pressure formed by the flush liquid in the opposite direction of the blood flow to isolate the blood from the motor, preventing the blood from entering the motor.

[0033] AsFigures 2-4 As shown, the flushing device 10 comprises a base 200 and a pump door 120, the pump door 120 is movably connected with the base 200, for example, rotatably connected, the pump door 120 is rotated relative to the base 200 to realize the closing or opening of the pump door 120 and the base 200.

[0034] The base 200 is provided with a pump assembly and a flushing pipeline 400. The flushing pipeline 400 is at least partially located between the pump assembly and the pump door 120. Specifically, the flushing pipeline 400 has a first pipe section 410 located between the pump assembly and the pump door 120, and when the pump door 120 closes the base 200, the pump door 120 and the pump assembly can jointly extrude the first pipe section 410 in the flushing pipeline 400.

[0035] For example, the pump assembly comprises a peristaltic unit 140, the peristaltic unit 140 is arranged in the base 200 and corresponds to the first pipe section 410 of the flushing pipeline 400, the peristaltic unit 140 has a plurality of peristaltic pieces 141, the plurality of peristaltic pieces 141 are arranged in sequence along the extension direction of the flushing pipeline 400, the peristaltic pieces 141 and the pump door 120 are distributed on two opposite sides in the radial direction of the flushing pipeline 400 (specifically, the first pipe section 410) and can jointly act on the flushing pipeline 400.

[0036] In one embodiment, the pump assembly further comprises a rotating shaft, a plurality of cams are arranged on the rotating shaft, the plurality of cams are sequentially and drivingly installed on the rotating shaft in the axial direction, each cam is sleeved with a peristaltic piece 141, the cams on the rotating shaft make the peristaltic pieces 141 produce wave-shaped motion according to a certain time sequence, and each peristaltic piece 141 can move back and forth in the radial direction of the flushing pipeline 400. When the peristaltic piece 141 moves towards the flushing pipeline 400, it can jointly act with the pump door 120 to extrude the flushing pipeline 400, so that the fluid in the flushing pipeline 400 receives a continuous and time sequence related pushing force, thereby making the fluid flow and achieving the effect of conveying the fluid.

[0037] When the pump door 120 closes the base 200, the first pipe section 410 is located between the peristaltic unit 140 and the pump door 120. When the peristaltic unit 140 starts to work, the peristaltic unit 140 moves towards the pump door 120, thereby jointly extruding the flushing pipeline 400 with the pump door 120 to extrude the liquid in the flushing pipeline 400, and finally realizing the pumping function of the flushing device 10 to the liquid.

[0038] The flushing pipeline 400 further comprises a second pipe segment 420 in communication with the first pipe segment 410, and the flushing device 10 further comprises a pressure sensor 130 in contact with the second pipe segment 420 in the flushing pipeline 400, or in other words, the pressure sensor 130 is arranged on the outer wall of the flushing pipeline 400 (specifically the second pipe segment 420) to detect the pressure of the second pipe segment 420. The second pipe segment 420 is one of the segments of the flushing pipeline 400 that will not be extruded by the pump door 120 and / or the peristaltic unit 140.

[0039] In one of the embodiments, the base 200 is provided with a mounting channel 330 for the flushing pipeline 400 to pass through, and the pressure sensor 130 is at least partially located in the mounting channel 330. The base 200 is provided with a cover plate 300 covering part of the mounting channel 330, and the second pipe segment 420 is mounted in the mounting channel 330. The position of the second pipe segment 420 corresponds to the position of the cover plate 300, and the position of the pressure sensor 130 also corresponds to the position of the cover plate 300, and the pressure sensor 130 is located between the cover plate 300 and the pressure sensor 130. When the flushing pipeline 400 is mounted in the mounting channel 330, the cover plate 300 makes the pressure sensor 130 in contact with the second pipe segment 420 in the flushing pipeline 400, so that the pressure sensor 130 can detect the pressure of the second pipe segment 420.

[0040] For example, the flushing device 10 further comprises a control circuit electrically connected to the peristaltic unit 140, which can control the fluid pressure and flow rate in the flushing pipeline 400 by controlling the rotation speed of the peristaltic unit 140. The faster the rotation speed of the rotating shaft, the faster the fluid delivery speed.

[0041] For example, the control circuit in the flushing device 10 can be integrated in the flushing device 10 (such as arranged in the accommodating cavity 220) or integrated in the control device 20, and the present application does not limit this.

[0042] The ventricular assist device 30 has a cannula, an impeller arranged in the cannula, and a motor, a motor shaft of which extends out of an opening at a distal end of a motor housing and is connected with the impeller, the motor shaft rotates to drive the impeller to rotate, and the motor shaft is supported by bearings located in the motor housing. Generally, a radial bearing is arranged at the distal end opening of the motor housing to support the motor shaft. However, since the motor of the interventional ventricular assist device 30 is arranged in the human body, blood may flow into the motor from the gap between the motor shaft and the motor housing or the distal radial bearing at the distal end opening of the motor housing. A large amount of blood entering the motor will affect the normal operation of the motor, causing problems such as increased load and transmission failure. Therefore, in the interventional ventricular assist system, a method of filling flushing fluid is often used to prevent blood from entering the motor of the ventricular assist device 30, and at the same time, the heat generated during the operation of the motor can be discharged through the flushing fluid. One end of the flushing pipeline 400 can be connected to a liquid infusion bottle or bag, which can provide saline or heparin flushing fluid; the other end of the flushing pipeline 400 can be accommodated in a catheter of the ventricular assist device 30, which is connected to the proximal end of the motor, so that the flushing pipeline 400 is connected to the proximal end of the motor, the distal end of the motor is connected to the cannula, and the flushing fluid entering the motor flows out from the distal end of the motor. The flow direction of the liquid delivered by the flushing device 10 is opposite to the direction of pumping blood in the ventricular assist device 30, so as to realize the fluid sealing of the distal end of the motor of the ventricular assist device 30, and avoid the blood entering the motor through the gap between the motor shaft and the motor housing or the distal radial bearing to cause motor failure.

[0043] To ensure the fluid sealing effect, the pressure at the output port of the flushing pipeline 400 needs to be continuously greater than or equal to the blood flow pressure, so as to provide reliable back pressure for the ventricular assist device 30 and ensure the safe operation of the ventricular assist device 30. However, for different users, the motor speed of the ventricular assist device 30 set by the user will be different, and the blood pressure of the user himself / herself will also be different, so that the blood pressure pumped by the ventricular assist device 30 of each user is different, and the required motor speed in different scenarios (such as surgical scenarios and daily use scenarios) will be different, and the motor speed will also be adjusted according to the physical condition of the user, so that the blood pressure pumped by the ventricular assist device 30 will change during the operation of the ventricular assist device 30. This change will change the pressure barrier formed between the flushing pipeline pressure and the blood pressure, and the flushing pipeline pressure set by the user may not be adjusted in time, and the flushing pipeline pressure set too large may cause excessive anticoagulation or affect the treatment of diabetic patients due to large flow of flushing fluid; and the flushing pipeline pressure set too small may cause blood to enter the motor, increase the risk of thrombosis, and damage the motor.

[0044] To solve the above problems, the application provides a pressure self-adaptive method. The pressure and flow characteristic curve of the flushing pipeline 400 is used to determine the environment pressure of the flushing pipeline in the ventricular assist device 30. The flushing fluid flow and pressure are self-adaptively adjusted according to the environment pressure. The best pressure of the flushing device 10 is automatically determined to ensure the pressure barrier between the blood and the motor in the ventricular assist device 30, avoid the excessive or insufficient pressure of the flushing pipeline, and ensure the safe operation of the ventricular assist device 30.

[0045] In combination with the above description, the application is described below from the perspective of method examples.

[0046] Please refer to Figure 5 , Figure 5 The pressure self-adaptive method provided by the application is applied to the flushing device 10 as shown in Figures 1-4 . As shown in Figure 5 , the method comprises the following steps.

[0047] S510, after the flushing device and the ventricular assist device are operated, a first pressure is obtained. The first pressure is the pressure of the flushing pipeline when the pump assembly drives the flushing fluid at a first flushing fluid flow rate.

[0048] After leaving the factory, the flushing pipeline 400 of the flushing device 10 is connected with the motor in the ventricular assist device 30 to provide flushing fluid to the motor through the flushing device 10 to form a fluid seal at the distal end of the motor. After the ventricular assist device 30 is implanted in the patient's body, the ventricular assist device 30 and the flushing device 10 are started. The ventricular assist device 30 can be operated at a target rotating speed, and the flushing device 10 can be operated at a pre-set default flushing fluid flow rate (i.e. the first flushing fluid flow rate). During the operation of the flushing device 10 at the first flushing fluid flow rate, the first pressure can be obtained by the pressure sensor 130 arranged in the flushing cavity. The first pressure is the pressure of the flushing pipeline detected when the flushing fluid is input into the flushing pipeline 400 at the first flushing fluid flow rate, i.e. the pressure detected by the pressure sensor 130.

[0049] The flow rate of the flushing liquid is related to the speed of the pump assembly. The faster the pump assembly rotates, the faster the flushing liquid flows. When the flow rate of the flushing pipeline 400 is constant and the pressure in the flushing pipeline 400 is balanced, if the flow rate of the flushing liquid is increased by increasing the rotating speed of the pump assembly, the pressure in the flushing pipeline 400 will gradually increase, thereby increasing the fluid pressure of the flushing liquid flowing into the motor. Similarly, when the flow rate of the flushing pipeline 400 is constant and the pressure in the flushing pipeline 400 is balanced, if the flow rate of the flushing liquid is reduced by reducing the rotating speed of the pump assembly, the pressure in the flushing pipeline 400 will gradually decrease, thereby reducing the fluid pressure of the flushing liquid flowing into the motor.

[0050] The application can control the flushing device 10 to operate at a default flushing liquid flow rate, estimate the optimal flushing liquid flow rate and the flushing pipeline pressure of the flushing device 10 at the current target rotating speed by detecting the flushing pipeline pressure at the flushing liquid flow rate, and improve the operating efficiency of the flushing device 10 while ensuring the safe operation of the ventricular assist device 30.

[0051] S520, calculating a target flushing liquid flow rate flowing into the flushing pipeline according to the first pressure.

[0052] When the ventricular assist system is operating, the flushing liquid pressure output by the flushing pipeline 400 needs to be greater than the blood pressure in the ventricular assist device 30 (i.e., the blood pressure in the sleeve of the ventricular assist device 30) in real time. That is, the flushing pipeline pressure depends on the blood pressure in the ventricular assist device 30. Therefore, the control circuit can estimate the current blood pressure in the ventricular assist device 30 (i.e., the ambient pressure of the flushing pipeline 400 at one end of the conduit of the ventricular assist device 30) according to the first pressure. The flushing pipeline pressure is preliminarily estimated according to the blood pressure in the ventricular assist device 30, and then the flushing liquid flow rate flowing into the flushing pipeline 400 is determined so that the flushing pipeline pressure can reach the preliminarily estimated flushing pipeline pressure.

[0053] For example, the target flushing liquid flow rate flowing into the flushing pipeline is calculated according to the first pressure, including: obtaining a first pressure curve, which is a relationship curve between the second pressure and the flushing pipeline pressure at the first flushing liquid flow rate; determining a third pressure corresponding to a preset pressure from the first pressure curve; and calculating the target flushing liquid flow rate according to the first pressure and the third pressure.

[0054] In the present application, before the ventricular assist system is shipped, the relationship curve between the ambient pressure of the flush conduit 400 received in the conduit of the ventricular assist device 30 and the flush conduit pressure at different flush fluid flow rates can be measured when the ventricular assist device 30 is placed in a test environment, and then the pressure curve at each flush fluid flow rate is stored in the control circuit. When the ventricular assist device 30 and the flush device 10 are running, the first pressure curve at the first flush fluid flow rate is obtained from the control circuit, and then the flush conduit pressure when the ambient pressure of the flush conduit 400 is 0 (i.e. the third pressure) can be determined according to the first pressure curve. The third pressure is the pressure of the flush conduit when the ambient pressure of the flush conduit 400 is 0, i.e. the pressure of the flush conduit when there is no blood in the motor in the ventricular assist device 30.

[0055] Optionally, the calculating the target flush fluid flow rate according to the first pressure and the third pressure comprises: obtaining a second pressure curve, the second pressure curve being a relationship curve of the flush fluid flow rate and the flush conduit pressure when the flush device is not connected with the ventricular assist device; determining a first conduit pressure drop corresponding to the first flush fluid flow rate according to the second pressure curve; calculating a second pressure according to the first pressure and the third pressure; obtaining a third pressure curve, the third pressure curve being a relationship curve of the flush fluid flow rate and the flush conduit pressure at the second pressure; calculating an estimated pressure according to the first conduit pressure drop and the second pressure; and determining the target flush fluid flow rate corresponding to the estimated pressure from the third pressure curve.

[0056] In the present application, before the ventricular assist system is shipped, the relationship curve between the ambient pressure of the flush conduit 400 received in the conduit of the ventricular assist device 30 and the flush conduit pressure at different flush fluid flow rates can be measured when the ventricular assist device 30 is placed in a test environment, and then the pressure curve at each flush fluid flow rate is stored in the control circuit. When the ventricular assist device 30 and the flush device 10 are running, the first pressure curve at the first flush fluid flow rate is obtained from the control circuit, and then the flush conduit pressure when the ambient pressure of the flush conduit 400 is 0 (i.e. the third pressure) can be determined according to the first pressure curve. The third pressure is the pressure of the flush conduit when the ambient pressure of the flush conduit 400 is 0, i.e. the pressure of the flush conduit when there is no blood in the motor in the ventricular assist device 30.

[0057] In the present application, before the ventricular assist system is shipped, the second pressure curve between the flow rate of the flushing fluid in the flushing device 10 and the pressure of the flushing conduit when the ventricular assist device 30 is placed in a test environment and the flushing device 10 is not connected to the ventricular assist device 30 can be measured, and then the second pressure curve is stored in the control circuit. The second pressure curve can represent the relationship between the pressure drop in the flushing conduit 400 and the flow rate of the flushing fluid. When the flushing device 10 is running, the control circuit can determine the conduit pressure drop corresponding to the current first flushing fluid flow rate from the second pressure curve. The first conduit pressure drop is the pressure loss in the flushing conduit 400 at the first flushing fluid flow rate.

[0058] In order to prevent blood in the ventricular assist device 30 from entering its motor, the pressure of the flushing fluid output by the flushing conduit 400 in the flushing device 10 needs to be greater than the blood pressure in the ventricular assist device 30 (or the blood pressure in the cannula). Considering the conduit pressure drop of the flushing conduit 400 itself, the required flushing conduit pressure (i.e., the estimated pressure) can be roughly estimated according to the second pressure and the first conduit pressure drop. The estimated pressure is equal to the sum of the second pressure and the first conduit pressure drop.

[0059] In the present application, before the ventricular assist system is shipped, the relationship curve between the flow rate of the flushing fluid in the flushing device 10 and the pressure of the flushing conduit at different ambient pressures of the flushing conduit 400 when the ventricular assist device 30 is placed in a test environment can be measured, and then the pressure curve at each ambient pressure is stored in the control circuit. When the ventricular assist device 30 and the flushing device 10 are running, the control circuit obtains the third pressure curve corresponding to the second pressure from the plurality of pressure curves, and determines the flushing fluid flow rate (i.e., the target flushing fluid flow rate) when the flushing conduit pressure reaches the estimated pressure according to the third pressure curve.

[0060] S530, calculating a target pressure according to the target flushing fluid flow rate, so that the outlet pressure of the flushing conduit 400 is greater than the second pressure, and the second pressure is the ambient pressure of the flushing conduit.

[0061] The estimated pressure is a rough estimate, and the deviation can be large. If the flushing conduit pressure is too large, a large amount of flushing fluid will enter the patient's body, causing excessive anticoagulation to affect the patient's treatment; if the flushing conduit pressure is too small, it will not form a fluid seal for the motor, causing blood to enter the motor and damage the motor. Therefore, after the estimated pressure is estimated, the control circuit can further estimate the flushing conduit pressure according to the target flushing fluid flow rate to calculate a more accurate target pressure, so as to realize precise control of the flushing conduit pressure.

[0062] The target pressure is in a preset pressure range, and the preset pressure range is 300 mmHg-1100 mmHg. The flushing pipeline can bear a fixed pressure due to its material characteristics. When the pressure of the flushing pipeline is greater than the maximum pressure that can be borne, the flushing pipeline 400 will be broken due to too large pressure. Therefore, in the operation of the flushing device 10, in order to ensure the service life of the flushing pipeline 400, the target pressure needs to be in the preset pressure range, which is the pressure range that can be borne by the flushing pipeline 400.

[0063] Optionally, the target pressure is calculated according to the target flushing liquid flow rate, comprising: determining the second pipeline pressure drop corresponding to the target flushing liquid flow rate from the second pressure curve; and substituting the second pipeline pressure drop and the second pressure into a target formula to calculate the target pressure, wherein the target formula is , wherein the is a pipeline pressure drop, the is an ambient pressure of the flushing pipeline, and the k is an adjustment coefficient, and the k is greater than 1.

[0064] Because the pipeline pressure drop of the flushing pipeline 400 is different under different flushing liquid flow rates, after the target flushing liquid flow rate is determined, the pipeline pressure drop can be further determined according to the target flushing liquid flow rate, so as to reduce the deviation of the target pressure.

[0065] The control circuit determines the second pipeline pressure drop corresponding to the target flushing liquid flow rate from the second pressure curve, and then reestimates the flushing pipeline pressure according to the second pipeline pressure drop and the second pressure. Specifically, the control circuit substitutes the second pipeline pressure drop and the second pressure into the target formula to calculate the target pressure. Because it is necessary to ensure that the flushing liquid pressure output by the flushing pipeline 400 is greater than the second pressure in real time, the sum of the second pipeline pressure drop and the second pressure is multiplied by k to make the flushing liquid form a fluid seal in the motor, wherein the k is greater than 1. For example, the k is greater than or equal to 1.5, for example, the k is 1.5, 1.7, 1.8, etc.

[0066] In the present application, the control circuit can automatically determine the maximum flushing pipeline pressure of the flushing device 10 when the ventricular assist device 30 operates at the target rotating speed through the pre-measured pressure curve and the default flushing liquid flow rate, which can reduce the influence of the flushing liquid on the patient while ensuring the safe operation of the ventricular assist device 30.

[0067] In one possible example, the method further comprises: adjusting the flushing liquid flow rate to maintain the flushing pipeline pressure as the target pressure; and recalculating the target pressure when the rotating speed of the ventricular assist device changes or the fluctuation value of the flushing pipeline pressure exceeds a preset value.

[0068] Wherein, after the target pressure is calculated, the control circuit can maintain the flushing pipeline pressure at the target pressure by adjusting the flushing liquid flow rate. When the rotation speed of the ventricular assist device 30 changes, the pumping flow rate of the ventricular assist device 30 also changes, so that the blood pressure in the ventricular assist device 30 also changes. Therefore, during the operation of the flushing device 10, if the rotation speed of the ventricular assist device 30 changes, the control circuit can take the pressure detected by the pressure sensor 130 after the rotation speed of the ventricular assist device 30 changes as the first pressure, and then recalculate the target pressure using the above method.

[0069] The flushing liquid delivered by the flushing device 10 has a certain viscosity. After the flushing device 10 operates for a period of time, the flushing liquid in the flushing pipeline 400 may be condensed together, or the flushing liquid may be pasted or attached to the inner wall of the pipeline, the filter screen arranged in the pipeline, and the motor gap, or the blood in the human body may be condensed or pasted in the motor gap. This situation can cause a tendency of blockage in the flushing pipeline 400, that is, due to the condensation, pasting, or attachment of the flushing liquid, the flushing liquid in the flushing pipeline 400 is blocked but not blocked, or due to the condensation, pasting, or attachment of the blood, the motor gap is blocked but not blocked, that is, the pipeline in the abnormal state can also deliver the flushing liquid, but the flow rate of the delivered flushing liquid is less than the current fluid flow rate corresponding to the outlet pressure of the flushing pipeline. When the flushing pipeline 400 or the motor gap is blocked, the flushing pipeline pressure gradually increases. Therefore, during the operation of the flushing device 10, the control circuit can monitor the flushing pipeline pressure in real time. If the flushing pipeline pressure suddenly increases by a preset value, it is considered that the current flushing pipeline 400 or the motor gap is blocked. The control circuit can take the pressure detected by the current pressure sensor 130 as the first pressure to recalculate the target pressure.

[0070] In the embodiments of the present application, the control circuit recalculates the target pressure when the flushing pipeline pressure changes or the environmental pressure of the flushing pipeline 400 changes, so as to maintain the pressure barrier between the blood in the casing of the ventricular assist device 30 and the distal end of the motor in real time, avoid the flushing pipeline pressure being too large or too small, and ensure the safe operation of the ventricular assist device 30.

[0071] In a possible example, when the target drug needs to be delivered, the method further includes: obtaining the concentration of the target drug; and recalculating the target flushing liquid flow rate according to the concentration of the target drug.

[0072] Wherein, when the patient needs to accurately control the input of the target drug, the control circuit can calculate the target flushing liquid flow rate according to the concentration of the target drug, and then determine the target pressure according to the target flushing liquid flow rate. In an example, the target drug can be an anticoagulant drug such as heparin, glucose, a blood vessel drug, a diuretic drug, etc.

[0073] For example, when the patient needs to precisely control the input of heparin at 150 IU / h, if the current flushing fluid heparin concentration is 25 IU / ml, then the target flushing fluid flow rate is 6 mL / h. The control circuit can determine the second line pressure drop corresponding to the target flushing fluid flow rate from the second pressure curve, and then substitute the second pressure and the newly determined second line pressure drop into the target formula to recalculate the target pressure.

[0074] It can be seen that the present application proposes a pressure adaptive method. After the flushing device is connected to the ventricular assist device, a first pressure is obtained, which is the flushing line pressure when the pump assembly drives the flushing fluid at a first flushing fluid flow rate. A target flushing fluid flow rate flowing into the flushing line is calculated according to the first pressure. A target pressure is calculated according to the target flushing fluid flow rate, so that the outlet pressure of the flushing line is greater than a second pressure, which is the ambient pressure of the flushing line. The present application calculates the appropriate flushing fluid flow rate according to the currently detected flushing line pressure, and then calculates the optimal flushing line pressure according to the flushing fluid flow rate, so that the outlet pressure of the flushing line is greater than its ambient pressure in real time, so that the pressure barrier between the blood in the ventricular assist device and the motor is kept in a stable state, ensuring the safe operation of the ventricular assist device.

[0075] The above mainly introduces the scheme of the embodiments of the present application from the perspective of the execution process of the method. It can be understood that, in order to implement the above functions, the network device comprises a hardware structure and / or a software module corresponding to the execution of each function. Those skilled in the art should easily realize that, in combination with the unit and algorithm steps of each example described in the embodiments provided herein, the present application can be realized in the form of hardware or a combination of hardware and computer software. Whether a certain function is executed in the form of hardware or computer software driving hardware depends on the specific application and design constraints of the technical solution. Professional technicians can use different methods to implement the described functions for each specific application, but such implementation should not be considered beyond the scope of the present application.

[0076] For example, the present application also provides a control circuit of a flushing device, the flushing device comprising a flushing line for conveying flushing fluid and a pump assembly for driving the flow of flushing fluid, the control circuit comprising one or more processors, the one or more processors being configured to: after the flushing device and the ventricular assist device are operated, obtain a first pressure, the first pressure being the flushing line pressure when the pump assembly drives the flushing fluid at a first flushing fluid flow rate; calculate a target flushing fluid flow rate flowing into the flushing line according to the first pressure; and calculate a target pressure according to the target flushing fluid flow rate, so that the outlet pressure of the flushing line is greater than a second pressure, the second pressure being the ambient pressure of the flushing line.

[0077] For example, the present application also provides a ventricular assist system, which comprises:

[0078] a ventricular assist device;

[0079] a flushing device for providing flushing fluid to the ventricular assist device, the flushing device comprising a flushing pipeline for conveying the flushing fluid and a pump assembly for driving the flushing fluid to flow;

[0080] a control circuit for controlling the ventricular assist device and the pump assembly to operate, the control circuit being configured to perform some or all of the steps described in the above method.

[0081] wherein the control circuit of each of the above schemes has a function of implementing the corresponding steps performed by the medical device in the above method; the function can be implemented by hardware, or by executing corresponding software by hardware.

[0082] In the embodiments of the present application, the control circuit can also be a chip or a chip system, for example, a system on chip (SoC).

[0083] Please refer to Figure 6 , Figure 6 is a structural schematic diagram of a medical device provided by an embodiment of the present application, which comprises one or more processors, one or more memories, one or more communication interfaces, and one or more programs; the one or more programs are stored in the memory and configured to be executed by the one or more processors.

[0084] The above program comprises instructions for performing the following steps:

[0085] after the flushing device and the ventricular assist device operate, obtaining a first pressure, the first pressure being the pressure of the flushing pipeline when the pump assembly drives the flushing fluid at a first flushing fluid flow rate;

[0086] calculating a target flushing fluid flow rate flowing into the flushing pipeline according to the first pressure;

[0087] calculating a target pressure according to the target flushing fluid flow rate, so that the outlet pressure of the flushing pipeline is greater than a second pressure, the second pressure being the ambient pressure of the flushing pipeline.

[0088] wherein all the related contents of each scenario involved in the above method embodiments can be cited to the function description of the corresponding function module, which will not be repeated here.

[0089] It should be understood that the above-mentioned memory can include read-only memory and random access memory, and provide instructions and data to the processor. Part of the memory can also include non-volatile random access memory. For example, the memory can also store device type information.

[0090] In the embodiments of the present application, the processor of the above-mentioned device can be a central processing unit (CPU), and the processor can also be other general-purpose processors, digital signal processors (DSP), application-specific integrated circuits (ASIC), field programmable gate arrays (FPGA) or other programmable logic devices, discrete gates or transistor logic devices, discrete hardware components, etc. The general-purpose processor can be a microprocessor or the processor can also be any conventional processor, etc.

[0091] It should be understood that "at least one" in the embodiments of the present application refers to one or more, and "multiple" refers to two or more. The "and / or" describes the association relationship of the associated objects, which means that there can be three relationships, for example, A and / or B, which can represent the following cases: A exists alone, A and B exist together, and B exists alone, where A and B can be singular or plural. The character " / " generally represents that the associated objects before and after it are in an "or" relationship. "At least one of the following" or similar expressions refers to any combination of these items, including single item or any combination of multiple items. For example, at least one of a, b, or c, can represent: a, b, c, a-b, a-c, b-c, or a-b-c, where a, b, and c can be single or multiple.

[0092] In addition, unless otherwise stated, the ordinal numbers "first", "second", etc. mentioned in the embodiments of the present application are used to distinguish a plurality of objects, and are not used to limit the order, time sequence, priority or importance of the plurality of objects. For example, the first information and the second information are only used to distinguish different information, and do not mean that the contents, priority, sending order or importance of the two kinds of information are different.

[0093] In the implementation process, each step of the above-mentioned method can be completed by the integrated logic circuit of hardware in the processor or the instruction in the form of software. The steps of the method disclosed in the embodiments of the present application can be directly embodied as hardware processor execution completion, or executed by hardware and software units in the processor. The software unit can be located in a mature storage medium in the field, such as random access memory, flash memory, read-only memory, programmable read-only memory, electrically erasable programmable memory, register, etc. The storage medium is located in the memory, and the processor executes the instructions in the memory, and combines the hardware to complete the steps of the above-mentioned method. To avoid repetition, it will not be described in detail here.

[0094] The embodiment of the present application further provides a computer storage medium, wherein the computer storage medium stores a computer program for electronic data exchange, and the computer program causes a computer to execute part or all of steps of any method described in the above method embodiments.

[0095] The embodiment of the present application further provides a computer program product, which includes a non-transitory computer-readable storage medium storing a computer program, and the computer program is operable to cause a computer to execute part or all of steps of any method described in the above method embodiments. The computer program product can be a software installation package.

[0096] It should be noted that, for the above-mentioned method embodiments, in order to simply describe, they are all described as a series of action combinations, but those skilled in the art should know that the present application is not limited to the order of actions described, because according to the present application, some steps can be performed in other order or simultaneously. Secondly, those skilled in the art should know that the embodiments described in the specification all belong to preferred embodiments, and the actions and modules involved are not necessarily necessary for the present application.

[0097] In the above embodiments, the description of each embodiment has its own focus, and the parts not described in detail in a certain embodiment can be referred to the related description of other embodiments.

[0098] In several embodiments provided by the present application, it should be understood that the disclosed device can be implemented in other ways. For example, the device embodiments described above are only schematic. The division of the above units is only a logical function division. There can be another division manner in actual implementation. For example, a plurality of units or components can be combined or integrated into another system, or some features can be ignored or not executed. In addition, the displayed or discussed mutual couplings or direct couplings or communication connections between the units can be indirect couplings or communication connections through some interfaces, devices or units, and can be electrical or other forms.

[0099] The units described as separate components can or can not be physically separate, and the components displayed as units can or can not be physical units, that is, they can be located in one place, or can be distributed on a plurality of network units. According to actual needs, some or all of the units can be selected to achieve the purpose of the embodiment of the present application.

[0100] In addition, each of the functional units in the various embodiments of the present application can be integrated in one processing unit, or each unit can be physically present separately, or two or more units can be integrated in one unit. The integrated unit can be realized in the form of hardware or in the form of a software functional unit.

[0101] The integrated unit, if realized in the form of a software functional unit and sold or used as an independent product, can be stored in a computer readable memory. Based on such understanding, the technical solutions of the present application, essentially or in part, or all or part of the technical solutions can be embodied in the form of a software product. The computer software product is stored in a memory and includes several instructions for causing a computer device (which can be a personal computer, a server, or a TRP, etc.) to execute all or part of the steps of the various embodiments of the method of the present application. The aforementioned memory includes various media that can store program codes, such as a U disk, a read-only memory (ROM), a random access memory (RAM), a mobile hard disk, a magnetic disk or an optical disk, etc.

[0102] Those of ordinary skill in the art can understand that all or part of the steps of the various methods of the above embodiments can be completed by a program instructing relevant hardware, and the program can be stored in a computer readable memory, which can include a flash disk, a ROM, a RAM, a magnetic disk or an optical disk, etc.

[0103] The embodiments of the present application are described in detail above, and the principles and implementation manners of the present application are described by applying specific examples. The above description of the embodiments is only to help understand the method of the present application and its core idea; at the same time, for those of ordinary skill in the art, according to the idea of the present application, the specific implementation manner and application range will be changed, and the above description of the embodiments is not to be understood as a limitation of the present application.

Claims

1. A control circuit for a rinsing device, characterized in that The control circuit includes one or more processors configured to perform the following steps: acquiring a first pressure, the first pressure being a pressure of the flush line when the pump assembly drives the flush fluid at a first flush fluid flow rate; calculating a target flush fluid flow rate into the flush line based on the first pressure; calculating a target pressure based on the target flush fluid flow rate, such that an outlet pressure of the flush line is greater than a second pressure, the second pressure being an ambient pressure of the flush line; wherein the calculating the target flush fluid flow rate into the flush line based on the first pressure includes: acquiring a first pressure curve, the first pressure curve being a relationship curve between the second pressure and the flush line pressure at the first flush fluid flow rate; determining a third pressure corresponding to a preset pressure from the first pressure curve; acquiring a second pressure curve, the second pressure curve being a relationship curve between a flush fluid flow rate and the flush line pressure when the flush device is not connected to the ventricular assist device; determining a first line pressure drop corresponding to the first flush fluid flow rate based on the second pressure curve; calculating the second pressure based on the first pressure and the third pressure; acquiring a third pressure curve, the third pressure curve being a relationship curve between the flush fluid flow rate and the flush line pressure at the second pressure; calculating an estimated pressure based on the first line pressure drop and the second pressure; determining the target flush fluid flow rate corresponding to the estimated pressure from the third pressure curve.

2. The control circuit of claim 1, wherein, In the calculating the target pressure based on the target flush fluid flow rate, the control circuit performs the following steps: determining a second line pressure drop corresponding to the target flush fluid flow rate from the second pressure curve; The second line pressure drop and the second pressure are substituted into a target formula to calculate the target pressure, the target formula being , the is a line pressure drop, the is an ambient pressure of the flush line, and the k is an adjustment factor, the k being greater than 1.

3. The control circuit of claim 1, wherein, the control circuit further performs the following steps: adjusting the flush fluid flow rate of the flush device to maintain the flush line pressure as the target pressure; re-calculating the target pressure when a rotational speed of the ventricular assist device changes or a fluctuation value of the flush line pressure exceeds a preset value.

4. The control circuit of claim 1, wherein, In a case where a target drug needs to be delivered, the control circuit further performs the following steps: acquiring a concentration of the target drug; re-determining the target flush fluid flow rate based on the concentration of the target drug.

5. The control circuit according to any one of claims 1 to 4, characterized in that, The target pressure is in a preset pressure range, the preset pressure range being 300 mmHg-1100 mmHg.

6. A ventricular assist system, characterized by The ventricular assist system includes: a ventricular assist device; a flush device configured to provide a flush fluid to the ventricular assist device, the flush device including a flush line configured to deliver the flush fluid and a pump assembly configured to drive a flow of the flush fluid; a control circuit configured to control the ventricular assist device and the pump assembly, the control circuit being configured to perform the steps of any one of claims 1-5.

7. A medical device, characterized by A computer readable storage medium storing a computer program for electronic data interchange, wherein the computer program causes a computer to perform the steps of any of claims 1-5.

8. A computer-readable storage medium, characterized in that, A computer readable storage medium storing a computer program for electronic data interchange, wherein the computer program causes a computer to perform the steps of any of claims 1-5.

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