Blood glucose monitoring device and method

Abstract

The invention discloses a blood glucose monitoring device and method.The blood glucose monitoring device is characterized in that an interstitial fluid gathering module in the device is connected between a control module and a first sensor and used for gathering subcutaneous tissue fluid under the control of the control module, and the first sensor is used for generating electrochemical reaction with the skin surface of the gathered subcutaneous tissue fluid to output first current; the second sensor is connected with the reference electrode and used for generating electrochemical reaction with the skin surface attached to the reference electrode to output a second current, and the first voltage detection module is connected between the first sensor and the control module and used for monitoring a first voltage value of the first current and sending the first voltage value to the control module; the second voltage detection module is connected between the second sensor and the control module and used for monitoring a second voltage value of the second current and sending the second voltage value to the control module, and the control module is used for obtaining a blood glucose concentration value according to the first voltage value and the second voltage value.

Description

Technical Field

[0001] The present invention relates to the field of medical health monitoring technology, and more specifically, to a blood glucose monitoring device and method. Background Art

[0002] Blood glucose monitoring is of vital importance for the treatment and management of diabetes. At present, there are two main methods of blood glucose monitoring, one is the traditional blood glucose monitoring method, and the other is the non-invasive continuous glucose monitoring (CGM) method. Among them, the traditional blood glucose monitoring method, such as fingertip capillary blood glucose monitoring, although it can provide accurate blood glucose readings, it requires repeated puncture of the skin to draw blood, which brings inconvenience and pain to patients and seriously affects patient compliance. Non-invasive continuous glucose monitoring (CGM) methods, such as monitoring blood glucose on the skin surface by collecting skin tissue fluid, do not require puncturing the skin and can provide continuous and comprehensive blood glucose information throughout the day, but this detection method is often contaminated by secretions such as sweat and uric acid on the skin surface, generating interference current, which seriously affects the accuracy of blood glucose monitoring. Summary of the invention

[0003] One purpose of the embodiments of the present invention is to provide a new technical solution for blood sugar monitoring.

[0004] According to a first aspect of the present invention, there is provided a blood glucose monitoring device, comprising: an interstitial fluid aggregation module, a first sensor, a second sensor, a first voltage detection module, a second voltage detection module, a reference electrode, and a control module, wherein;

[0005] The tissue fluid gathering module is connected between the control module and the first sensor, and is used to gather subcutaneous tissue fluid under the control of the control module;

[0006] The first sensor is used to generate an electrochemical reaction with the skin surface of the subcutaneous tissue fluid collected by the tissue fluid collection module to output a first current;

[0007] The second sensor is connected to the reference electrode, and is used to generate an electrochemical reaction with the skin surface to which the reference electrode is attached to output a second current;

[0008] The first voltage detection module is connected between the first sensor and the control module, and is used to monitor a first voltage value of the first current and send the first voltage value to the control module;

[0009] The second voltage detection module is connected between the second sensor and the control module, and is used to monitor a second voltage value of the second current and send the second voltage value to the control module;

[0010] The control module is used to obtain a blood glucose concentration value according to the first voltage value and the second voltage value.

[0011] Optionally, the first voltage detection module and the second voltage detection module are the same, and the device also includes a gating module, the first voltage detection module is connected between the control module and the gating module, and the control module is connected to the control end of the gating module, and is used to control the gating module to respectively gate the first sensor and the second sensor at different times.

[0012] Optionally, the tissue fluid aggregation module includes a boost circuit and a aggregation electrode, the boost circuit is connected between the control module and the first end of the aggregation electrode, the second end of the aggregation electrode is connected to the first sensor, and the aggregation electrode aggregates subcutaneous tissue fluid under the boosting action of the boost circuit.

[0013] Optionally, the apparatus further comprises a communication module, the communication module is connected to the control module, and the communication module is used to send the first voltage value and the second voltage value to a target device under the control of the control module;

[0014] The control module is used to receive the blood glucose concentration value returned by the target device for the first voltage value and the second voltage value through the communication module.

[0015] According to a second aspect of the present invention, there is provided a blood glucose monitoring method, which is applied to the device according to the first aspect, and the method comprises:

[0016] Under the condition of controlling the tissue fluid gathering module to gather subcutaneous tissue fluid, acquiring a first voltage value detected by the first voltage detection module and a second voltage value detected by the second voltage detection module;

[0017] A blood glucose concentration value is determined according to the first voltage value and the second voltage value.

[0018] Optionally, the method further comprises:

[0019] In a case where the tissue fluid gathering module is not controlled to gather subcutaneous tissue fluid, acquiring a third voltage value detected by the first voltage detection module and a fourth voltage value detected by the second voltage detection module;

[0020] The step of determining the blood glucose concentration value according to the first voltage value and the second voltage value includes:

[0021] The blood glucose concentration value is determined according to the first voltage value, the second voltage value, the third voltage value, and the fourth voltage value.

[0022] Optionally, determining the blood glucose concentration value according to the first voltage value, the second voltage value, the third voltage value, and the fourth voltage value includes:

[0023] determining a first current value according to the first voltage value and the third voltage value;

[0024] determining a second current value according to the second voltage value and the fourth voltage value;

[0025] Determine a target current value according to the first current value and the second current value; wherein the target current value is a current difference between the first current value and the second current value;

[0026] According to a preset mapping relationship and the target current value, a blood glucose concentration value corresponding to the target current value is determined; wherein the preset mapping relationship is a corresponding relationship between current and blood glucose concentration.

[0027] Optionally, the method further comprises:

[0028] Receive sampling parameters; wherein the sampling parameters include a sampling start time and a sampling time interval;

[0029] In response to the sampling parameters, determining a plurality of sampling moments;

[0030] When the sampling start time is reached, controlling the tissue fluid gathering module not to gather subcutaneous tissue fluid;

[0031] When a sampling start time other than the sampling start time is reached among the plurality of sampling times, the tissue fluid collection module is controlled to collect subcutaneous tissue fluid.

[0032] Optionally, after controlling the tissue fluid gathering module to gather subcutaneous tissue fluid, the method further comprises:

[0033] When the control time is greater than or equal to the preset time, the step of acquiring the first voltage value monitored by the first voltage detection module and the second voltage value monitored by the second voltage detection module is performed.

[0034] Optionally, the first voltage detection module and the second voltage detection module are the same, the device further comprises a gating module, the first voltage detection module is connected between the control module and the gating module, the control module is connected to a control end of the gating module, and is used to control the gating module to respectively gate the first sensor and the second sensor at different times, and the method further comprises:

[0035] When any sampling time among the plurality of sampling times is reached, the gating module is controlled to sequentially gate the first sensor and the second sensor.

[0036] One beneficial effect of the present invention is that, by setting a reference electrode and a second sensor, a channel can be provided for the electrochemical reaction between secretions such as sweat and uric acid on the skin surface and the glucose reaction enzyme on the second sensor, and by setting a second voltage detection module, a second voltage value corresponding to the noise current generated by the electrochemical reaction can be detected, so that the first voltage value can be corrected and calculated based on the second voltage value corresponding to the noise current in blood glucose monitoring to avoid the influence of secretions such as sweat and uric acid on the skin surface on the accuracy of blood glucose monitoring, thereby improving the accuracy of blood glucose monitoring. In addition, the blood glucose monitoring method can be implemented without penetrating the skin and will not affect the patient's compliance. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] The accompanying drawings, which are incorporated in and constitute a part of the specification, illustrate embodiments of the invention and, together with the description, serve to explain the principles of the invention.

[0038] Figure 1 is a schematic structural diagram of a blood glucose monitoring device according to an embodiment of the present invention;

[0039] Figure 2 is a structural schematic diagram of a blood glucose monitoring device according to another embodiment of the present invention;

[0040] Figure 3 is a flow chart of a blood glucose monitoring method according to an embodiment of the present invention;

[0041] Figure 4 1 is a flow chart of a blood glucose monitoring method according to an example of the present invention. DETAILED DESCRIPTION

[0042] Various exemplary embodiments of the present invention will now be described in detail with reference to the accompanying drawings. It should be noted that the relative arrangement of components and steps, numerical expressions and numerical values ​​set forth in these embodiments do not limit the scope of the present invention unless otherwise specifically stated.

[0043] The following description of at least one exemplary embodiment is merely illustrative in nature and is in no way intended to limit the invention, its application, or uses.

[0044] Technologies, methods, and equipment known to ordinary technicians in the relevant art may not be discussed in detail, but where appropriate, the technologies, methods, and equipment should be considered as part of the specification.

[0045] In all examples shown and discussed herein, any specific values ​​should be interpreted as merely exemplary and not limiting. Therefore, other examples of the exemplary embodiments may have different values.

[0046] It should be noted that like reference numerals and letters refer to similar items in the following figures, and therefore, once an item is defined in one figure, it need not be further discussed in subsequent figures.

[0047] The treatment of diabetes requires long-term monitoring of blood glucose levels in order to adjust the treatment plan to achieve blood glucose control goals and reduce the risk of complications. At present, blood glucose monitoring methods are mainly divided into traditional blood glucose monitoring methods and non-invasive continuous glucose monitoring (CGM) methods. Among them, traditional blood glucose monitoring methods, such as fingertip capillary blood glucose monitoring, although it can provide accurate blood glucose readings, require repeated puncture of the skin for blood sampling, which brings inconvenience and pain to patients and seriously affects patient compliance. Non-invasive continuous glucose monitoring (CGM) methods, such as blood glucose monitoring on the skin surface after collecting skin tissue fluid, do not need to puncture the skin, and can provide continuous and comprehensive blood glucose information throughout the day. However, this monitoring method is often interfered by secretions such as sweat and uric acid on the skin surface. This is because these secretions react electrochemically with the glucose sensor to generate interference current, which seriously affects the accuracy of blood glucose monitoring.

[0048] Therefore, how to accurately measure the glucose level in tissue fluid without penetrating the skin while avoiding the influence of secretions on the skin surface on the blood glucose measurement results has become a technical problem that needs to be solved urgently.

[0049] In response to the above technical problems, the embodiments of the present disclosure relate to a new technical solution for a blood glucose monitoring device. Figure 1 FIG. 1 shows a schematic diagram of the structure of a blood glucose monitoring device 100 according to some embodiments. Figure 1 As shown, the blood glucose monitoring device 100 includes: a tissue fluid accumulation module 11, a first sensor 12, a second sensor 13, a first voltage detection module 15, a second voltage detection module 16, a reference electrode 14, and a control module 10.

[0050] The control module 10 may be a microprocessor, a digital signal processor (DSP), a programmable logic controller (PLC), etc. Those skilled in the art should understand that the specific type of the control module is not limited here.

[0051] The first sensor 12 and the second transducer 13 may both be glucose sensors. The glucose sensor carries glucose enzyme, which can undergo an electrochemical reaction with glucose to generate a reaction current.

[0052] The first voltage detection module 15 and the second voltage detection module 16 can both be high-precision voltage acquisition modules such as AFE (Analog Front End).

[0053] The tissue fluid gathering module 11 is connected between the control module 10 and the first sensor 12 , and is used for gathering subcutaneous tissue fluid under the control of the control module 10 .

[0054] Specifically, the skin-fitting end of the tissue fluid gathering module 11 is used to fit with the skin, the first connection end of the tissue fluid gathering module 11 is connected to the first end of the control module 10, and the tissue fluid gathering module 11 is used to gather subcutaneous tissue fluid at the skin where its skin-fitting end fits under the control of the control module 10. The second connection end of the tissue fluid gathering module 11 is connected to the first connection end of the first sensor 12. The first sensor 12 is used to generate an electrochemical reaction with the skin surface of the subcutaneous tissue fluid gathered by the tissue fluid gathering module 11 (i.e., the skin surface where the skin-fitting end of the tissue fluid gathering module 11 fits) to output a first current.

[0055] The second sensor 13 is connected to the reference electrode 14 , and is used for generating an electrochemical reaction with the skin surface to which the reference electrode 14 is attached to output a second current.

[0056] Specifically, the reference electrode 14 can also be attached to the skin, and the first end of the second sensor 13 is connected to the reference electrode 14, which can facilitate the second sensor 13 to electrochemically react with sweat, uric acid and other secretions on the skin surface attached to the reference electrode 14 to output the second current. The second current here can also be called noise current.

[0057] The first voltage detection module 15 is connected between the first sensor 12 and the control module 10, and is used to monitor the first voltage value of the first current, and send the first voltage value to the control module 10. The second voltage detection module 16 is connected between the second sensor 13 and the control module 10, and is used to monitor the second voltage value of the second current, and send the second voltage value to the control module 10.

[0058] Specifically, one end of the first voltage detection module 15 is connected to the second end of the control module 10, and the other end is connected to the second end of the first sensor 12. One end of the second voltage detection module 16 is connected to the third end of the control module 10, and the other end is connected to the second end of the second sensor 13. When the first current flows through the first voltage detection module 15, due to the large internal resistance of the first voltage detection module 15, the first current will generate a voltage drop when passing through the first voltage detection module 15. Therefore, the first voltage value can be obtained by detecting the voltage drop through the first voltage detection module 15. Similarly, the second voltage detection module 16 can also detect the voltage drop generated when the second current flows through itself to obtain a second voltage value.

[0059] In some embodiments, in order to avoid the accuracy of blood glucose monitoring being affected by the type difference between the first voltage detection module and the second voltage detection module (i.e., the internal resistance difference), the first voltage detection module and the second voltage detection module can be set to be voltage detection modules of the same type and specification (i.e., voltage detection modules with the same internal resistance).

[0060] The control module 10 is used to obtain a blood glucose concentration value according to the first voltage value and the second voltage value.

[0061] For example, the internal resistance of the first voltage detection module and the second voltage detection module is the same. After the control module receives the first voltage value and the second voltage value, since the second voltage value is the voltage value corresponding to the noise current (i.e., the second current), the first voltage value and the second voltage value can be subtracted to obtain the actual voltage value. Then, based on the internal resistance value of the first voltage detection module or the second voltage detection module, it is determined to convert the actual voltage value into the actual current value. Based on the correspondence between the actual current value and the preset current and blood glucose concentration, the blood glucose concentration value corresponding to the actual current value is determined.

[0062] According to the embodiment of the present application, by setting a reference electrode and a second sensor, a channel can be provided for the sweat, uric acid and other secretions on the skin surface to undergo an electrochemical reaction with the glucose reaction enzyme on the second sensor, and by setting a second voltage detection module, a second voltage value corresponding to the noise current generated by the electrochemical reaction can be detected, so that the first voltage value can be corrected and calculated based on the second voltage value corresponding to the noise current in blood glucose monitoring to avoid the sweat, uric acid and other secretions on the skin surface affecting the accuracy of blood glucose monitoring, thereby improving the accuracy of blood glucose monitoring. In addition, the blood glucose monitoring method can be implemented without penetrating the skin and will not affect the patient's compliance.

[0063] In some embodiments, Figure 2 As shown, the first voltage detection module 15 and the second voltage detection module 16 are the same, that is, there is only one voltage detection module in the blood glucose monitoring device, and the voltage detection module can be the first voltage detection module or the second voltage detection module. This article only takes the voltage detection module as the first voltage detection module 15 as an example.

[0064] The blood glucose monitoring device 100 also includes a gating module 17. The first voltage detection module 15 is connected between the control module 10 and the gating module 17. The control module 10 is connected to the control end of the gating module 17 to control the gating module 17 to respectively select the first sensor 12 and the second sensor 13 at different times.

[0065] Specifically, one end of the first voltage detection module 15 is connected to the second end of the control module 10, and the other end is connected to the first connection end of the gating module 17, and the second connection end of the gating module 17 can switch between the first sensor 12 and the second sensor 13. The third end of the control module 10 is connected to the control end of the gating module 17, and the control module 10 can control the second connection end of the gating module 17 to respectively gate the first sensor 12 and the second sensor 13 at different times. When the second connection end of the gating module 17 selects the first sensor 12, the voltage value detected by the first voltage detection module 15 is the first voltage value corresponding to the first current, and when the second connection end of the gating module 17 selects the second sensor 13, the voltage value detected by the first voltage detection module 15 is the second voltage value corresponding to the second current.

[0066] According to an embodiment of the present application, by setting up a voltage detection module and respectively selecting the first sensor and the second sensor through the selection module to obtain the first voltage value and the second voltage value, it is possible to reduce the hardware quantity of the blood glucose monitoring device and save costs without affecting the voltage acquisition of the first voltage value and the second voltage value.

[0067] In some embodiments, the tissue fluid aggregation module 11 includes a boost circuit 111 and a aggregation electrode 112, the boost circuit 111 is connected between the control module 10 and the first end of the aggregation electrode 112, the second end of the aggregation electrode 112 is connected to the first sensor 12, and the aggregation electrode 112 aggregates subcutaneous tissue fluid under the boosting action of the boost circuit 111.

[0068] In this embodiment, the skin-fitting end of the tissue fluid aggregation module 11 is the skin-fitting end of the aggregation electrode 112, which is used to fit with the skin. The first connection end of the tissue fluid aggregation module 11 is connected to the first end of the control module 10, that is, the first connection end of the boost circuit 111 is connected to the first end of the control module 10. The second connection end of the boost circuit 111 is connected to the first end of the aggregation electrode. The second connection end of the tissue fluid aggregation module 11 is connected to the first connection end of the first sensor 12, that is, the second end of the aggregation electrode 12 is connected to the first connection end of the first sensor 12. The boost circuit 111 is used to boost the voltage of the aggregation electrode 112 to form an electric field to gather the subcutaneous tissue fluid of the skin to which the aggregation electrode 112 fits.

[0069] According to the embodiment of the present application, an electric field is formed at the gathering electrode by a boost circuit to gather tissue fluid, which can facilitate the gathering of subcutaneous tissue fluid. In addition, the boost circuit is relatively easy to control and can be convenient for user operation.

[0070] In some embodiments, the blood glucose monitoring device 100 also includes a communication module 18, which is connected to the control module 10. The communication module 18 is used to send the first voltage value and the second voltage value to the target device under the control of the control module 10, and the control module 10 is used to receive the blood glucose concentration value returned by the target device for the first voltage value and the second voltage value through the communication module 18.

[0071] In this embodiment, the communication module 18 may be a wireless communication module, such as a wifi communication module, a Bluetooth module, etc., or a wired communication module, such as a USB communication module, etc., or other communication modules.

[0072] In such Figure 2 In the example of the blood glucose monitoring device shown, the communication module 18 can be connected to the fourth terminal of the control module 10 .

[0073] The control module 10 can control the communication module 18 to send the first voltage value and the second voltage value to the target device. The target device can be an electronic device, such as a mobile phone, a computer, etc., or a server, which is not limited here.

[0074] In the case where the target device is an electronic device, the electronic device may also communicate with the server to upload the first voltage value and the second voltage value to the server via the electronic device.

[0075] After receiving the first voltage value and the second voltage value, the target device can obtain the blood glucose concentration value according to the first voltage value and the second voltage value. In addition, the target device can send the blood glucose concentration value returned for the first voltage value and the second voltage value to the control module 10 through the communication module 18.

[0076] In some examples, the blood glucose monitoring device also includes a display module.

[0077] In this example, after the control module receives the blood glucose concentration value returned by the target device in response to the first voltage value and the second voltage value, the control module may further control the display module to display the blood glucose concentration value.

[0078] In some examples, the target device can also be connected to a medical platform such as a hospital consultation platform. When the target device returns the blood glucose concentration value to the control module, it can also send the blood glucose concentration value to the medical platform so that the medical platform can provide medical advice to the user based on the blood glucose concentration value.

[0079] According to an embodiment of the present application, by setting a communication module to upload the first voltage value and the second voltage value to the target device so that the target device calculates the blood glucose concentration value, the power consumption of the blood glucose monitoring device can be reduced and the battery life can be extended.

[0080] Figure 3A blood glucose monitoring method is shown, which is applied to Figure 1 or Figure 2 The blood glucose monitoring device shown in FIG. 1 can be specifically composed of Figure 1 or Figure 2 The control module of the blood glucose monitoring device shown is executed, wherein the method includes: step S3100 and step S3200.

[0081] Step S3100 , when controlling the tissue fluid gathering module 11 to gather subcutaneous tissue fluid, obtaining a first voltage value detected by the first voltage detection module 15 and a second voltage value detected by the second voltage detection module 16 .

[0082] In this embodiment, the first voltage detection module and the second voltage detection module may be the same as shown in Figure 2, that is, Figure 2 The first voltage detection module in the embodiment may be a first voltage detection module or a second voltage detection module. The first voltage detection module and the second voltage detection module may also be as follows Figure 1 The ones shown are not the same and are not limited here.

[0083] After the user has attached the blood glucose monitoring device to the skin, the tissue fluid gathering module 11 can be controlled to gather subcutaneous tissue fluid to obtain a first voltage value and a second voltage value.

[0084] Those skilled in the art should understand that the specific method of controlling the tissue fluid aggregation module 11 to aggregate subcutaneous tissue fluid is not limited in step S3100. That is, the tissue fluid aggregation module 11 may be controlled to aggregate subcutaneous tissue fluid at a specific time, or the tissue fluid aggregation module 11 may be controlled to aggregate subcutaneous tissue fluid upon receiving an aggregation instruction, or other control methods may be used, which are not limited here.

[0085] Step S3200, determining the blood glucose concentration value according to the first voltage value and the second voltage value.

[0086] For example, the internal resistance of the first voltage detection module and the second voltage detection module is the same. After the control module obtains the first voltage value and the second voltage value, since the second voltage value is the voltage value corresponding to the noise current (i.e., the second current), the first voltage value and the second voltage value can be subtracted to obtain the actual voltage value. Then, based on the internal resistance value of the first voltage detection module or the second voltage detection module, it is determined to convert the actual voltage value into the actual current value. Based on the correspondence between the actual current value and the preset current and blood glucose concentration, the blood glucose concentration value corresponding to the actual current value is determined.

[0087] According to the embodiment of the present application, by controlling the tissue fluid gathering module 11 to gather subcutaneous tissue fluid, the first voltage value detected by the first voltage detection module 15 and the second voltage value detected by the second voltage detection module 16 are obtained, and the blood glucose concentration value is determined according to the first voltage value and the second voltage value. It is possible to introduce the second voltage value generated by the electrochemical reaction of secretions such as sweat and uric acid on the skin surface into the calculation process of the blood glucose concentration value to correct the first voltage value, thereby avoiding the influence of secretions such as sweat and uric acid on the skin surface on the accuracy of blood glucose monitoring, thereby improving the accuracy of blood glucose monitoring. In addition, the blood glucose monitoring method can be implemented without penetrating the skin, and will not affect the patient's compliance.

[0088] Theoretically, when the tissue fluid aggregation module is not controlled to aggregate subcutaneous tissue fluid, the third voltage value detected by the first voltage detection module and the fourth voltage value detected by the second voltage detection module should be the same. However, since the blood glucose monitoring device 100 includes a first sensor and a second sensor, although both sensors are glucose sensors, it is almost impossible for the two sensors to be exactly the same, that is, the degree of reaction of the first sensor and the second sensor to glucose may be different, and the corresponding measured third voltage value and fourth voltage value will also be different. If the blood glucose concentration value is calculated directly by the first voltage value and the second voltage value, there will be a problem of inaccurate blood glucose monitoring due to the hardware difference between the first sensor and the second sensor themselves. In order to solve this problem, in some embodiments, the method also includes: step S4100.

[0089] Step S4100 , when the tissue fluid gathering module 11 is not controlled to gather subcutaneous tissue fluid, a third voltage value detected by the first voltage detection module 15 and a fourth voltage value detected by the second voltage detection module 16 are acquired.

[0090] In this embodiment, the third voltage value is the voltage error value of the first sensor, and the fourth voltage value is the voltage error value of the second sensor.

[0091] In these embodiments, determining the blood glucose concentration value according to the first voltage value and the second voltage value in step S3200 includes: step S4200.

[0092] Step S4200, determining the blood glucose concentration value according to the first voltage value, the second voltage value, the third voltage value, and the fourth voltage value.

[0093] For example, the first voltage value may be subtracted from the third voltage value to obtain the first actual voltage value, the second voltage value may be subtracted from the fourth voltage value to obtain the second actual voltage value, and then the first actual voltage value may be subtracted from the second actual voltage value to obtain the denoised voltage value. The denoised voltage value is then divided by the internal resistance value of the voltage detection module to obtain the denoised current value. The corresponding blood glucose concentration value is determined based on the denoised current value.

[0094] In some embodiments, step S4200 determines the blood glucose concentration value according to the first voltage value, the second voltage value, the third voltage value, and the fourth voltage value, including: steps S4200.1 to S4200.4.

[0095] Step S4200.1, determining a first current value according to the first voltage value and the third voltage value.

[0096] In this embodiment, the first actual voltage value is determined according to the voltage difference between the first voltage value and the third voltage value, and the first actual voltage value is divided by the internal resistance value of the first voltage detection module to obtain the first current value.

[0097] Step S4200.2, determining a second current value according to the second voltage value and the fourth voltage value.

[0098] In this embodiment, the second actual voltage value is determined according to the voltage difference between the second voltage value and the fourth voltage value, and the second actual voltage value is divided by the internal resistance value of the second voltage detection module to obtain the second current value.

[0099] Step S4200.3, determining a target current value according to the first current value and the second current value.

[0100] In this embodiment, the target current value is a current difference between the first current value and the second current value.

[0101] Step S4200.4, determining the blood glucose concentration value corresponding to the target current value according to the preset mapping relationship and the target current value.

[0102] In this embodiment, the preset mapping relationship is the corresponding relationship between the current and the blood glucose concentration, that is, for each current value, there is a corresponding blood glucose concentration value.

[0103] In some embodiments, the method further includes: steps S5100 to S5400.

[0104] Step S5100, receiving sampling parameters.

[0105] In this embodiment, the sampling parameters include a sampling start time and a sampling time interval.

[0106] In some examples, the sampling parameter is sent to a control module of a blood glucose monitoring device via a target device, such as an electronic device.

[0107] In some other examples, the blood glucose monitoring device includes an input module for a user to input sampling parameters.

[0108] Step S5200, determining a plurality of sampling moments in response to the sampling parameters.

[0109] Exemplarily, the sampling start time is 0:00, the sampling time interval is 1 hour, and the multiple sampling times are 0:00, 1:00, 2:00, 3:00...23:00, 0:00.

[0110] Step S5300: When the sampling start time is reached, the tissue fluid gathering module 11 is controlled not to gather subcutaneous tissue fluid.

[0111] Continuing with the above example, the sampling start time is 0:00. When the current time reaches 0:00, the tissue fluid aggregation module is controlled not to aggregate subcutaneous tissue fluid.

[0112] In the above embodiment where the tissue fluid gathering module includes a boost circuit and a gathering electrode, the step of controlling the tissue fluid gathering module not to gather subcutaneous tissue fluid includes:

[0113] The voltage boosting circuit is controlled not to boost the voltage of the focusing electrode.

[0114] Step S5400: When a non-sampling start time among the multiple sampling times is reached, the tissue fluid collection module 11 is controlled to collect subcutaneous tissue fluid.

[0115] Continuing the above example, the sampling start time is 0:00, and the sampling interval is 1h, then the multiple sampling times are 0:00, 1:00, 2:00, 3:00...23:00, 0:00. When the current time reaches 1:00, 2:00 or other non-sampling start times, the tissue fluid gathering module is controlled to gather subcutaneous tissue fluid.

[0116] In the above embodiment where the tissue fluid gathering module includes a boost circuit and a gathering electrode, the control of the tissue fluid gathering module to gather subcutaneous tissue fluid includes:

[0117] The boost circuit is controlled to boost the voltage of the focusing electrode.

[0118] The accumulated subcutaneous tissue fluid has a direct impact on blood glucose monitoring. In order to avoid the problem that the amount of accumulated subcutaneous tissue fluid is small due to the short time for the tissue fluid accumulation module to accumulate subcutaneous tissue fluid, thereby reducing the accuracy of blood glucose monitoring, the embodiment of the present application sets the theoretical time for tissue fluid accumulation according to experimental experience, that is, the preset time, so as to detect the first voltage value and the second voltage value when the control time for the tissue fluid accumulation module to accumulate subcutaneous tissue fluid reaches the preset time.

[0119] Based on this, in some embodiments, after controlling the tissue fluid gathering module to gather subcutaneous tissue fluid in step S3100 or step S5400, the method further includes:

[0120] When the control time is greater than or equal to the preset time, the step of acquiring the first voltage value monitored by the first voltage detection module and the second voltage value monitored by the second voltage detection module is performed.

[0121] In this embodiment, the preset time length may be the time length required for the corresponding tissue fluid aggregation module to aggregate subcutaneous tissue fluid when the first voltage value tends to be stable during the historical tissue fluid aggregation process.

[0122] In the above embodiment where the controlling the tissue fluid gathering module to gather subcutaneous tissue fluid comprises: controlling the voltage boosting circuit to boost the gathering electrode, the control duration may be the duration of the voltage boosting circuit on the gathering electrode.

[0123] In the above embodiment where the first voltage detection module and the second voltage detection module are the same and the blood glucose monitoring device further includes a gating module, the method further includes:

[0124] When any sampling time among the plurality of sampling times is reached, the control gating module sequentially gates the first sensor 12 and the second sensor 13 .

[0125] Continuing the above example, the multiple sampling times are 0:00, 1:00, 2:00, 3:00...23:00, 0:00. When the current time reaches the starting sampling time 0:00, the first sensor and the second sensor are sequentially selected by the selection module to obtain the third voltage value and the fourth voltage value. When the current time reaches 1:00, the first sensor and the second sensor are sequentially selected by the selection module to obtain the first voltage value and the second voltage value.

[0126] In some embodiments, in order to reduce the power consumption of the blood glucose monitoring device, when any sampling time among a plurality of sampling times is reached, the first sensor and the second sensor are controlled to respectively undergo electrochemical reactions with the skin.

[0127] In this embodiment, the electrochemical reaction between the glucose reaction enzymes on the first sensor and the second sensor and the skin can be initiated by sending a trigger instruction to the first sensor and the second sensor.

[0128] like Figure 4 As shown, it shows a blood glucose monitoring method according to an example of the present application. The method is executed by a control module of a blood glucose monitoring device, and the method includes steps S1 to S13.

[0129] Step S1, receiving sampling parameters sent by an electronic device.

[0130] In this example, the sampling parameters include the sampling start time and the sampling time interval.

[0131] In some other examples, sampling parameters input by a user may also be received.

[0132] Step S2, determining a plurality of sampling moments in response to the sampling parameters.

[0133] Exemplarily, the sampling start time is 0:00, the sampling time interval is 1 hour, and the multiple sampling times are 0:00, 1:00, 2:00, 3:00...23:00, 0:00.

[0134] Step S3, whether the current time reaches the sampling start time; if yes, execute step S4, if not, return to step S3.

[0135] Step S4, sending trigger instructions to the first sensor and the second sensor respectively to trigger the electrochemical reaction.

[0136] In this example, the first sensor is triggered to undergo an electrochemical reaction with the skin to generate a reverse current, and the second sensor is triggered to undergo an electrochemical reaction with the skin to generate a reverse current.

[0137] Step S5, enabling the first sensor to obtain a third voltage value detected by the first voltage detection module.

[0138] In this example, the third voltage value is a voltage value corresponding to a reverse current generated by an electrochemical reaction between the first sensor and the skin.

[0139] Step S6, enabling the second sensor to obtain a fourth voltage value detected by the first voltage detection module.

[0140] In this example, the fourth voltage value is a voltage value corresponding to a reverse current generated by an electrochemical reaction between the second sensor and the skin.

[0141] Step S7, whether the current time reaches the non-sampling start time among the multiple sampling times; if so, execute step S8, if not, return to step S7.

[0142] Step S8, controlling the voltage boosting circuit to boost the voltage of the focusing electrode, and sending trigger instructions to the first sensor and the second sensor respectively to trigger the electrochemical reaction.

[0143] Triggering the electrochemical reaction in this step is basically the same as in step S4, and will not be repeated here.

[0144] Step S9, control whether the duration is greater than or equal to the preset duration; if so, execute step S10, if not, return to step S8.

[0145] Step S10, enabling the first sensor to obtain a first voltage value detected by a first voltage detection module.

[0146] Step S11, enabling the second sensor to obtain a second voltage value detected by the first voltage detection module.

[0147] Step S12: sending the first voltage value, the second voltage value, the third voltage value, and the fourth voltage value to the server via the electronic device.

[0148] In this example, the server calculates the blood glucose concentration value according to the first voltage value, the second voltage value, the third voltage value, and the fourth voltage value to obtain the corresponding blood glucose concentration value. The server calculates the blood glucose concentration value in the same way as the control module calculates the blood glucose concentration value, which will not be repeated here.

[0149] Step S13, receiving the blood glucose concentration value returned by the server based on the first voltage value, the second voltage value, the third voltage value, and the fourth voltage value.

[0150] The present invention may be a system, a method and / or a computer program product. The computer program product may include a computer-readable storage medium carrying computer-readable program instructions for causing a processor to implement various aspects of the present invention.

[0151] A computer-readable storage medium may be a tangible device that can hold and store instructions used by an instruction execution device. A computer-readable storage medium may be, for example, but not limited to, an electrical storage device, a magnetic storage device, an optical storage device, an electromagnetic storage device, a semiconductor storage device, or any suitable combination of the foregoing. More specific examples of computer-readable storage media (a non-exhaustive list) include: a portable computer disk, a hard disk, a random access memory (RAM), a read-only memory (ROM), an erasable programmable read-only memory (EPROM or flash memory), a static random access memory (SRAM), a portable compact disk read-only memory (CD-ROM), a digital versatile disk (DVD), a memory stick, a floppy disk, a mechanical encoding device, such as a punch card or a raised structure in a groove on which instructions are stored, and any suitable combination of the foregoing. As used herein, a computer-readable storage medium is not to be interpreted as a transient signal per se, such as a radio wave or other freely propagating electromagnetic wave, an electromagnetic wave propagating through a waveguide or other transmission medium (e.g., a light pulse through a fiber optic cable), or an electrical signal transmitted through a wire.

[0152] The computer-readable program instructions described herein can be downloaded from a computer-readable storage medium to each computing / processing device, or downloaded to an external computer or external storage device via a network, such as the Internet, a local area network, a wide area network, and / or a wireless network. The network can include copper transmission cables, optical fiber transmissions, wireless transmissions, routers, firewalls, switches, gateway computers, and / or edge servers. The network adapter card or network interface in each computing / processing device receives the computer-readable program instructions from the network and forwards the computer-readable program instructions for storage in the computer-readable storage medium in each computing / processing device.

[0153] The computer program instructions for performing the operation of the present invention may be assembly instructions, instruction set architecture (ISA) instructions, machine instructions, machine-related instructions, microcode, firmware instructions, state setting data, or source code or object code written in any combination of one or more programming languages, including object-oriented programming languages, such as Smalltalk, C++, etc., and conventional procedural programming languages, such as "C" language or similar programming languages. Computer-readable program instructions may be executed entirely on a user's computer, partially on a user's computer, as an independent software package, partially on a user's computer, partially on a remote computer, or entirely on a remote computer or server. In the case of a remote computer, the remote computer may be connected to the user's computer via any type of network, including a local area network (LAN) or a wide area network (WAN), or may be connected to an external computer (e.g., using an Internet service provider to connect via the Internet). In some embodiments, an electronic circuit, such as a programmable logic circuit, a field programmable gate array (FPGA), or a programmable logic array (PLA), may be personalized by utilizing the state information of the computer-readable program instructions, and the electronic circuit may execute the computer-readable program instructions, thereby realizing various aspects of the present invention.

[0154] Various aspects of the present invention are described herein with reference to the flow charts and / or block diagrams of the methods, devices (systems) and computer program products according to embodiments of the present invention. It should be understood that each box of the flow chart and / or block diagram and the combination of each box in the flow chart and / or block diagram can be implemented by computer-readable program instructions.

[0155] These computer-readable program instructions can be provided to a processor of a general-purpose computer, a special-purpose computer, or other programmable data processing device, thereby producing a machine, so that when these instructions are executed by the processor of the computer or other programmable data processing device, a device that implements the functions / actions specified in one or more boxes in the flowchart and / or block diagram is generated. These computer-readable program instructions can also be stored in a computer-readable storage medium, and these instructions cause the computer, programmable data processing device, and / or other equipment to work in a specific manner, so that the computer-readable medium storing the instructions includes a manufactured product, which includes instructions for implementing various aspects of the functions / actions specified in one or more boxes in the flowchart and / or block diagram.

[0156] Computer-readable program instructions may also be loaded onto a computer, other programmable data processing apparatus, or other device so that a series of operating steps are performed on the computer, other programmable data processing apparatus, or other device to produce a computer-implemented process, thereby causing the instructions executed on the computer, other programmable data processing apparatus, or other device to implement the functions / actions specified in one or more boxes in the flowchart and / or block diagram.

[0157] The flow charts and block diagrams in the accompanying drawings show the possible architecture, functions and operations of the systems, methods and computer program products according to multiple embodiments of the present invention. In this regard, each box in the flow chart or block diagram can represent a part of a module, a program segment or an instruction, and a part of the module, a program segment or an instruction contains one or more executable instructions for realizing the specified logical function. In some alternative implementations, the functions marked in the box can also occur in a different order from the order marked in the accompanying drawings. For example, two consecutive boxes can actually be executed substantially in parallel, and they can sometimes be executed in the opposite order, depending on the functions involved. It should also be noted that each box in the block diagram and / or flow chart, and the combination of the boxes in the block diagram and / or flow chart can be implemented by a dedicated hardware-based system that performs the specified function or action, or can be implemented by a combination of dedicated hardware and computer instructions. It is well known to those skilled in the art that it is equivalent to implement it by hardware, implement it by software, and implement it by combining software and hardware.

[0158] Embodiments of the present invention have been described above, and the above description is exemplary, not exhaustive, and is not limited to the disclosed embodiments. Many modifications and variations will be apparent to those of ordinary skill in the art without departing from the scope and spirit of the described embodiments. The selection of terms used herein is intended to best explain the principles of the embodiments, practical applications, or technical improvements in the marketplace, or to enable other persons of ordinary skill in the art to understand the embodiments disclosed herein. The scope of the present invention is defined by the appended claims.

Claims

1. A blood glucose monitoring device, characterized in that: include: a tissue fluid aggregation module, a first sensor, a second sensor, a first voltage detection module, a second voltage detection module, a reference electrode, and a control module, wherein; The tissue fluid gathering module is connected between the control module and the first sensor, and is used to gather subcutaneous tissue fluid under the control of the control module; The first sensor is used to generate an electrochemical reaction with the skin surface of the subcutaneous tissue fluid collected by the tissue fluid collection module to output a first current; The second sensor is connected to the reference electrode, and is used to generate an electrochemical reaction with the skin surface to which the reference electrode is attached to output a second current; The first voltage detection module is connected between the first sensor and the control module, and is used to monitor a first voltage value of the first current and send the first voltage value to the control module; The second voltage detection module is connected between the second sensor and the control module, and is used to monitor a second voltage value of the second current and send the second voltage value to the control module; The control module is used to obtain a blood glucose concentration value according to the first voltage value and the second voltage value.

2. The device according to claim 1, characterized in that The first voltage detection module and the second voltage detection module are the same, and the device also includes a gating module, the first voltage detection module is connected between the control module and the gating module, and the control module is connected to the control end of the gating module, and is used to control the gating module to respectively gate the first sensor and the second sensor at different times.

3. The device according to claim 1, characterized in that The tissue fluid aggregation module includes a boost circuit and an aggregation electrode. The boost circuit is connected between the control module and the first end of the aggregation electrode. The second end of the aggregation electrode is connected to the first sensor. The aggregation electrode aggregates subcutaneous tissue fluid under the boost action of the boost circuit.

4. The device according to claim 1, characterized in that The device further includes a communication module, the communication module is connected to the control module, and the communication module is used to send the first voltage value and the second voltage value to a target device under the control of the control module; The control module is used to receive the blood glucose concentration value returned by the target device for the first voltage value and the second voltage value through the communication module.

5. A blood glucose monitoring method, characterized in that: Applied to the device according to any one of claims 1 to 4, the method comprises: Under the condition of controlling the tissue fluid gathering module to gather subcutaneous tissue fluid, acquiring a first voltage value detected by the first voltage detection module and a second voltage value detected by the second voltage detection module; A blood glucose concentration value is determined according to the first voltage value and the second voltage value.

6. The method according to claim 5, characterized in that The method further comprises: In a case where the tissue fluid gathering module is not controlled to gather subcutaneous tissue fluid, acquiring a third voltage value detected by the first voltage detection module and a fourth voltage value detected by the second voltage detection module; The step of determining the blood glucose concentration value according to the first voltage value and the second voltage value includes: The blood glucose concentration value is determined according to the first voltage value, the second voltage value, the third voltage value, and the fourth voltage value.

7. The method according to claim 6, characterized in that The step of determining the blood glucose concentration value according to the first voltage value, the second voltage value, the third voltage value, and the fourth voltage value includes: determining a first current value according to the first voltage value and the third voltage value; determining a second current value according to the second voltage value and the fourth voltage value; Determine a target current value according to the first current value and the second current value; wherein the target current value is a current difference between the first current value and the second current value; According to a preset mapping relationship and the target current value, a blood glucose concentration value corresponding to the target current value is determined; wherein the preset mapping relationship is a corresponding relationship between current and blood glucose concentration.

8. The method according to claim 6, characterized in that The method further comprises: Receive sampling parameters; wherein the sampling parameters include a sampling start time and a sampling time interval; In response to the sampling parameters, determining a plurality of sampling moments; When the sampling start time is reached, controlling the tissue fluid gathering module not to gather subcutaneous tissue fluid; When a sampling start time other than the sampling start time is reached among the plurality of sampling times, the tissue fluid collection module is controlled to collect subcutaneous tissue fluid.

9. The method according to claim 5, characterized in that After controlling the tissue fluid gathering module to gather subcutaneous tissue fluid, the method further includes: When the control time is greater than or equal to the preset time, the step of acquiring the first voltage value monitored by the first voltage detection module and the second voltage value monitored by the second voltage detection module is performed.

10. The method according to claim 8, characterized in that The first voltage detection module and the second voltage detection module are the same, the device further comprises a gating module, the first voltage detection module is connected between the control module and the gating module, the control module is connected to the control end of the gating module, and is used to control the gating module to respectively gate the first sensor and the second sensor at different times, the method further comprises: When any sampling time among the plurality of sampling times is reached, the gating module is controlled to sequentially gate the first sensor and the second sensor.

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