A soft nose swab based on pneumatic growth and a sampling method

Abstract

This invention relates to the field of medical devices, and more specifically, to a soft nasal swab based on pneumatic growth and a sampling method, comprising an axial drive section, an auxiliary support surface section, a middle folding surface section, and a front brush section connected sequentially from back to front; it addresses the problems of existing nasal swabs lacking elasticity, resulting in a poor sampling experience; the risk of cross-infection due to direct contact between medical personnel and subjects; and the inability to achieve automatic sampling. The axial drive end allows for deformation through inflation of different sections to adapt to movement in the sampling direction within the nasal cavity; the auxiliary support surface section controls the force transmission of the nasal swab during use; the middle folding surface section enables automatic folding and rotation; the front brush section improves sampling accuracy while achieving automatic sampling; the specific sampling method steps reduce cross-infection; the gas pressure drive and structural design of different parts of the nasal swab simplify the drive source; and safety risks are reduced.

Description

Technical Field

[0001] This invention relates to the field of medical devices, and more specifically, to a soft nasal swab based on aerodynamic growth and a sampling method. Background Technology

[0002] A nasal swab is a small tool used to collect material from the lining of the nasal cavity. The collected material will be used for testing or experiments.

[0003] Current nasal swabs are primarily small wooden sticks with a cotton swab attached to one end, the latter used for sampling. During the procedure, a doctor typically holds the smooth end of the stick and inserts the swab deep into the nostril, rotating it to collect liquids or solids from the nasal cavity wall. This type of nasal swab is rigid and lacks elasticity, easily causing injury to the nasal cavity wall and resulting in significant pain for the subject during sampling. Furthermore, the sampling process requires contact between medical staff and the subject, posing a risk of cross-infection.

[0004] How to achieve automated sampling while improving the experience of test subjects and avoiding cross-infection between medical staff and test subjects is an urgent problem to be solved in this field. Summary of the Invention

[0005] The present invention aims to overcome at least one of the defects (deficiencies) of the prior art and provide a soft nasal swab and sampling method based on pneumatic growth, which solves the problems of existing nasal swabs lacking elasticity, easily puncturing the inner wall of the subject's nasal cavity, resulting in a poor sampling experience; direct contact between medical staff and subjects is prone to cross-infection risk, and automatic sampling cannot be achieved.

[0006] The technical solution adopted by this invention is to provide a soft nasal swab based on pneumatic growth, which includes an axial drive section, an auxiliary support surface section, an intermediate folded surface section, and a front brush section connected sequentially from back to front. The nasal swab is cavity-shaped. The axial drive section is used to control the gas filling in the cavity and the sampling power of the nasal swab. The auxiliary support surface section is used to transmit the driving force of the axial drive section to the front brush section. The intermediate folded surface section is used to provide assistance for the transmitted driving force and to buffer the pressure on the front brush section. The front brush section is used to collect samples from the nasal cavity.

[0007] It is advantageous to use the axial drive section to inflate and deform other different segments of the nasal swab to adapt to the movement of the sampling direction in the nasal cavity; the auxiliary support surface section provides support to control the force transmission of the nasal swab during use; the middle folding surface section enables the nasal swab to automatically fold and rotate, so as to avoid puncturing the nasal cavity and improve the subject's experience; the front brush section automatically rotates and samples over a large area in the nasal cavity, improving sampling accuracy while avoiding direct contact between medical staff and subjects, thus achieving automatic sampling.

[0008] Furthermore, the front brush section is a spherical cavity with multiple brushes evenly distributed on its surface. The bottom of the spherical cavity is connected to the middle folded surface section, and the top of the spherical cavity is a smooth plane.

[0009] It is beneficial to increase the contact area between the nasal swab and the nasal cavity wall by multiple brushes arranged on the surface, thereby increasing the sample collection concentration; the connection of the middle folded surface section enables the front brush section to rotate and sample under its drive, shortening the sampling time and improving the sampling efficiency; the smooth surface section transmits the resistance it encounters in the nasal cavity along the axis to the middle folded surface section.

[0010] Furthermore, the intermediate folded surface section is a foldable cavity, which includes several layers of rings. The diameter of each ring decreases sequentially from back to front along the axial direction. When the intermediate folded surface section is squeezed by the front brush section, the multiple rings are squeezed and then overlap and shrink from front to back along the axial direction.

[0011] It is advantageous to couple the sampling rotation and the front pressure together through the middle folded surface segment to achieve elastic sampling of the nasal swab and improve the subject experience; the middle folded surface segment can be stretched and stacked along the axial direction through several layers of rings.

[0012] Furthermore, each ring includes multiple rhomboid faces, which are spliced ​​together along the circumferential direction to form a ring. When the middle folded section is squeezed by the front brush section, the rhomboid faces on each ring convert the axial force into a tangential force, and the multiple rings rotate and fold along the circumferential direction.

[0013] This allows the axial force to be converted into tangential force through the splicing of multiple rhomboid surfaces in each ring, thereby enabling the automatic rotation of the front brush section.

[0014] Furthermore, the auxiliary support surface segment is a cylindrical cavity, with its top connected to the bottom of the intermediate folded surface segment and its bottom connected to the top of the axial drive segment. The axial length of the auxiliary support surface segment is H3, the axial length of the intermediate folded surface segment is H2, and the axial length of the front brush segment is H1, where H3 > H1 + H2.

[0015] The auxiliary support surface segment has an axial length greater than the sum of the axial lengths of the middle folded surface segment and the front brush segment, which allows the auxiliary support surface segment to provide sufficient axial support, thereby preventing the force transmitted downward along the axial direction by the middle folded surface segment.

[0016] Furthermore, the axial drive section is a drum-shaped cavity, which includes a top drum surface and a bottom drum surface of the same diameter. The bottom drum surface is connected to the pressurizing device through a vent pipe. After being pressurized by the pressurizing device, the axial drive section expands in the axial direction and pushes the front brush section forward.

[0017] It is beneficial to provide inflation power through the pressurization device; the axial drive section provides a large area of ​​base support for the auxiliary support surface section, while providing a buffer space for the inflation of the nasal swab, so that the inflation deformation of each segment on the nasal swab can cooperate to complete the sampling task.

[0018] Furthermore, the diameter of the top drum surface is D4, the diameter of the auxiliary support surface segment is D3, the diameter of the bottom of the middle folded surface segment is D22, the diameter of the top of the middle folded surface segment is D21, the diameter of the brush formed on the outer edge of the front brush segment is D1, and the diameter of the vent pipe is D5, where D4 > D1 > D3 = D22 > D21 > D5.

[0019] The different diameters of the various segments in the nasal swab allow the soft nasal swab to perform different movements in each segment, adapting to the internal environment of the nasal cavity; the small diameter of the air tube increases the airflow velocity; the gradually decreasing diameter of the middle folded section from bottom to top achieves axial overlapping; the larger diameter of the outer edge of the brush compared to the middle folded section increases the sampling contact area; and the fact that the auxiliary support section and the bottom of the middle folded section have the same diameter improves the efficiency of pressure transmission along the axial direction.

[0020] A soft nasal swab sampling method based on aerodynamic growth is also provided, wherein the soft nasal swab includes the following steps:

[0021] S1. The subject remains still, the soft nasal swab is replaced and fixed, and the nasal swab is placed close to the lower part of the subject's nostrils by a robotic arm;

[0022] S2. Start the pressurization device to inflate the soft nasal swab. After the axial drive section, auxiliary support surface section, middle folding surface section and front brush section in the nasal swab expand in sequence, the front brush section extends into the nasal cavity to prepare for sampling.

[0023] S3. After the front brush segment is blocked at the sampling position inside the nasal cavity, the resistance is transmitted through the middle folded surface segment, so that the middle folded surface segment is folded down and rotated in the circumferential direction at the same time.

[0024] S4. The front brush segment connected to the middle folded surface segment is driven to rotate, thereby realizing the collection of biological samples inside the nasal cavity;

[0025] S5. After the nasal swab is collected, the robotic arm places the front brush section into the collection box, turns off the pressurization device, removes the soft nasal swab, and prepares for the next sampling.

[0026] This method helps avoid contact between medical staff and subjects during the sampling process, reducing cross-infection; the gas pressure drive and the structural design of different parts of the nasal swab allow a single drive source to complete different actions at different stages, making the operation simple; the soft material of the soft nasal swab reduces safety risks, and the deformation of the soft material adapts to changes in the nasal cavity environment, resulting in better sampling coverage.

[0027] Step S2 specifically includes:

[0028] S21. After the axial drive section is inflated, the gas quickly enters the front brush section through the cylindrical cavity, and the front brush section extends into the nasal cavity;

[0029] S22. The axial drive section and the auxiliary support section provide support for the intermediate folding section. After continuous inflation, each layer of rings in the intermediate folding section is fully unfolded.

[0030] S23. As the front brush segment gradually penetrates deeper, the forward resistance gradually increases. When it reaches the sampling position inside the nasal cavity, the squeezing resistance of the front brush segment is the greatest, and this resistance is transmitted to the middle folded surface segment.

[0031] It is beneficial to achieve elastic sampling of nasal swabs by observing the specific movement changes of the axial drive section, auxiliary support surface section and front brush section during inflation.

[0032] Step S3 specifically includes:

[0033] S31. The top of the front brush section is a smooth plane. When it reaches the sampling position inside the nasal cavity, it encounters the greatest resistance. The smooth plane transmits the resistance axially to the top of the middle folded surface section.

[0034] S32. The top of the intermediate folded surface segment transmits a portion of the resistance along the axial direction on its multi-layered rings to the bottom of the intermediate folded surface segment, and the multi-layered rings overlap along the axial direction under the action of this portion of resistance.

[0035] S33. The top of the intermediate folded surface segment transmits another part of the resistance in the rhomboid surface of each ring along the tangential direction. Since the bottom of the intermediate folded surface segment is connected to the auxiliary support surface segment, the auxiliary support surface segment provides support for the bottom of the intermediate folded surface segment and prevents this part of the resistance from continuing to be transmitted along the axial direction, so that the intermediate folded surface segment rotates along the tangential circumferential direction under the action of this part of the resistance.

[0036] It is beneficial to achieve large-area rotational sampling by observing the stress state and specific action changes of the intermediate folded surface segment at each stage.

[0037] Compared with existing technologies, the beneficial effects of this invention are as follows: The axial drive section inflates and deforms other different segments of the nasal swab to adapt to movement in the sampling direction within the nasal cavity; the auxiliary support surface section provides support to control the force transmission during use; the intermediate folding section enables automatic folding and rotation of the nasal swab to avoid puncturing the nasal cavity and improve the subject's experience; the front brush section automatically rotates and samples over a large area within the nasal cavity, improving sampling accuracy while avoiding direct contact between medical personnel and subjects, thus achieving automated sampling; the specific sampling method steps avoid contact between medical personnel and subjects during sampling, reducing cross-infection; the gas pressure drive and structural design of different parts of the nasal swab allow a single drive source to complete different actions at different stages, simplifying operation; the soft material of the soft nasal swab reduces safety risks, and the deformation of the soft material adapts to changes in the nasal cavity environment, resulting in better sampling coverage. Attached Figure Description

[0038] Figure 1 This is an overall structural diagram of the present invention.

[0039] Figure 2 This is a schematic diagram of the expanded state of the soft nasal swab of the present invention.

[0040] Figure 3 This is a schematic diagram of the retracted state of the soft nasal swab of the present invention.

[0041] Explanation of the symbols in the attached diagram: 1. Front brush section, 2. Middle folded surface section, 3. Auxiliary support surface section, 4. Axial drive section. Detailed Implementation

[0042] The accompanying drawings are for illustrative purposes only and should not be construed as limiting the invention. To better illustrate the following embodiments, some parts in the drawings may be omitted, enlarged, or reduced, and do not represent the actual product dimensions; it is understandable to those skilled in the art that some well-known structures and their descriptions may be omitted in the drawings.

[0043] Example 1

[0044] like Figure 1-3 As shown, this embodiment provides a soft nasal swab based on pneumatic growth, which includes an axial drive section 4, an auxiliary support surface section 3, an intermediate folded surface section 2, and a front brush section 1 connected sequentially from back to front. The nasal swab is cavity-shaped. The axial drive section 4 is used to control the gas filling in the cavity and the sampling power of the nasal swab. The auxiliary support surface section 3 is used to transmit the driving force of the axial drive section 4 to the front brush section 1. The intermediate folded surface section 2 is used to provide assistance for the transmitted driving force and to buffer the pressure on the front brush section 1. The front brush section 1 is used to collect samples from the nasal cavity.

[0045] In this embodiment, the axial drive section 4 provides the inflation power source for the nasal swab, enabling sampling after inflation and providing a buffer for the inflation process. The auxiliary support surface section 3 provides support for the intermediate folded surface section 2. The intermediate folded surface section 2 provides axial and radial force variations for sampling, thereby driving the front brush section 1 to rotate and extend for sampling. The front brush section 1 directly contacts the subject's nasal cavity, increasing the sampling contact area. The connection with the intermediate folded surface section 2 allows the brush to elastically extend, contract, and rotate during sampling, thereby achieving automatic sampling and improving the sampling experience.

[0046] The front brush section 1 is a spherical cavity with multiple brushes evenly distributed on its surface. The bottom of the spherical cavity is connected to the middle folded surface section 2, and the top of the spherical cavity is a smooth plane.

[0047] In this embodiment, the smooth surface has no brushes, so that when it encounters resistance in contact with the nasal cavity, it will not increase the subject's stinging sensation. At the same time, the smooth surface can completely transmit the resistance encountered by the front brush segment 1 along the axial direction, avoiding force dispersion. The multiple brushes evenly distributed on the surface of the spherical cavity greatly increase the sampling coverage area. When the front brush segment 1 is rotated, the large area of ​​brushes can collect more samples at the same time.

[0048] The middle folded section 2 is a foldable cavity, which includes several layers of rings. The diameter of each ring decreases sequentially from back to front along the axial direction. When the middle folded section 2 is squeezed by the front brush section 1, the multiple rings are squeezed and then overlap and shrink from front to back along the axial direction.

[0049] In this embodiment, the intermediate folded surface section 2 includes four rings. When the front brush section 1 is obstructed in the nasal cavity, its smooth surface transmits the resistance axially to the intermediate folded surface section 2. Since the top diameter of the intermediate folded surface section 2 is small and the bottom diameter is large, the upper rings fold downward after being squeezed until all the rings are stacked and contracted.

[0050] Each ring layer includes multiple rhomboid faces, which are spliced ​​together along the circumferential direction to form a ring. When the middle folded surface segment 2 is squeezed by the front brush segment 1, the rhomboid faces on each ring layer convert the axial force into a tangential force, and the multiple ring layers rotate and fold along the circumferential direction.

[0051] In this embodiment, the hypotenuses of the multiple rhomboid faces on the ring are connected one after the other, and the upper and lower parallel edges of the rhomboid faces form the edge of the ring, so that the multiple rings remain parallel. When the middle folded section 2 is subjected to axial pressure, part of the force undergoes unstable deformation due to the special structure of the rhomboid face, converting the axial force into a tangential force, which drives the rotation of the rhomboid face.

[0052] The auxiliary support section 3 is a cylindrical cavity, with its top connected to the bottom of the middle folded section 2 and its bottom connected to the top of the axial drive section 4. The axial length of the auxiliary support section 3 is H3, the axial length of the middle folded section 2 is H2, and the axial length of the front brush section 1 is H1. H3 > H1 + H2.

[0053] In this embodiment, the cylindrical cavity of the auxiliary support surface section 3 always maintains a rigid, fixed cylindrical shape. Regardless of the inflation and stress states of the middle folded surface section 2 and the front brush section 1, it can maintain high-strength support to control the movement of the sampling direction and limit the transmission of force along the axial direction when sampling is obstructed. The greater the axial length of the auxiliary support surface section 3, the stronger the support force it provides.

[0054] The axial drive section 4 is a drum-shaped cavity, which includes a top drum surface and a bottom drum surface of the same diameter. The bottom drum surface is connected to the pressurizing device through a vent pipe. After being pressurized by the pressurizing device, the axial drive section 4 expands in the axial direction and pushes the front brush section 1 forward.

[0055] In this embodiment, the top and bottom drum surfaces of the axial drive section 4 have the same diameter. When the nasal swab is in a deflated state without inflation, the rigid top drum surface and the rigid auxiliary support surface section 3 support each other, allowing it to quickly deform into position and enter the sampling state during the next inflation. The bottom drum surface rapidly directs the gas generated by the pressurizing device along the shaped auxiliary support surface section 3 into the front brush section 1 through the vent pipe, thereby enabling rapid sampling by the front brush section 1.

[0056] The diameter of the top drum surface is D4, the diameter of the auxiliary support surface section 3 is D3, the diameter of the bottom of the middle folded surface section 2 is D22, the diameter of the top of the middle folded surface section 2 is D21, the diameter of the brush formed on the outer edge of the front brush section 1 is D1, and the diameter of the vent pipe is D5, where D4 > D1 > D3 = D22 > D21 > D5.

[0057] In this embodiment, the diameter of the ventilation tube is much smaller than the diameter of the drumhead of the axial drive section 4 to increase the airflow velocity during inflation. The diameter of the auxiliary support section 3 is approximately half the diameter of the drumhead of the axial drive section 4. This satisfies both the diameter required to enter the nasal cavity and the need to provide sufficient support between the intermediate fold section 2 and the axial drive section 4. The top diameter of the intermediate fold section 2 is slightly smaller than its bottom diameter, with the difference being the sum of the wall thicknesses of the three rings. The diameter of the outer edge of the brush is larger than that of the intermediate fold section 2 and the auxiliary support section 3, ensuring that the brush makes full contact with the nasal cavity wall after entering the nasal cavity, thereby increasing the sample collection concentration.

[0058] Example 2

[0059] This embodiment also provides a soft nasal swab sampling method based on aerodynamic growth, wherein the soft nasal swab includes the following steps:

[0060] S1. The subject remains still, the soft nasal swab is replaced and fixed, and the nasal swab is placed close to the lower part of the subject's nostrils by a robotic arm;

[0061] S2. Start the pressurization device to inflate the soft nasal swab. After the axial drive section 4, auxiliary support section 3, middle folding section 2, and front brush section 1 in the nasal swab expand in sequence, the front brush section 1 extends into the nasal cavity to prepare for sampling.

[0062] S3. After the front brush section 1 is blocked at the sampling position inside the nasal cavity, the resistance is transmitted through the middle folded surface section 2, so that the middle folded surface section 2 is folded down and rotated in the circumferential direction at the same time.

[0063] S4. The front brush segment 1, which is connected to the intermediate folded surface segment 2, is driven to rotate, thereby collecting biological samples from inside the nasal cavity;

[0064] S5. After the nasal swab is collected, the front brush section 1 is placed in the collection box by the robotic arm, the pressurization device is turned off, the soft nasal swab is removed, and preparation is made for the next sampling.

[0065] Step S2 specifically includes:

[0066] S21. After the axial drive section 4 is inflated, the gas quickly enters the front brush section 1 through the cylindrical cavity, and the front brush section 1 extends into the nasal cavity.

[0067] S22. The axial drive section 4 and the auxiliary support section 3 provide support for the intermediate folding section 2. After continuous inflation, each layer of rings in the intermediate folding section 2 is fully unfolded.

[0068] S23. As the front brush section 1 gradually penetrates deeper, the forward resistance gradually increases. When it reaches the sampling position inside the nasal cavity, the squeezing resistance of the front brush section 1 is the greatest, and this resistance is transmitted to the middle folded surface section 2.

[0069] Step S3 specifically includes:

[0070] S31. The top of the front brush section 1 is a smooth plane. When it reaches the sampling position inside the nasal cavity, it encounters the greatest resistance. The smooth plane transmits the resistance axially to the top of the middle folded section 2.

[0071] S32. The top of the intermediate folded surface section 2 transmits a portion of the resistance along the axial direction on its multi-layered rings to the bottom of the intermediate folded surface section 2, and the multi-layered rings overlap along the axial direction under the action of this portion of resistance.

[0072] S33. The top of the intermediate folded surface segment 2 transmits another part of the resistance in the rhomboid surface of each ring along the tangential direction. Since the bottom of the intermediate folded surface segment 2 is connected to the auxiliary support surface segment 3, the auxiliary support surface segment 3 provides support for the bottom of the intermediate folded surface segment 2 and prevents this part of the resistance from continuing to be transmitted along the axial direction, so that the intermediate folded surface segment 2 rotates along the tangential circumferential direction under the action of this part of the resistance.

[0073] Obviously, the above embodiments of the present invention are merely examples for clearly illustrating the technical solution of the present invention, and are not intended to limit the specific implementation of the present invention. Any modifications, equivalent substitutions, and improvements made within the spirit and principles of the claims of the present invention should be included within the protection scope of the claims of the present invention.

Claims

1. A soft nasal swab based on aerodynamic growth, characterized in that, The nasal swab comprises an axial drive section, an auxiliary support surface section, an intermediate folded surface section, and a front brush section connected sequentially from back to front. The nasal swab is cavity-shaped. The axial drive section is used to control the gas filling in the cavity and the sampling power of the nasal swab. The auxiliary support surface section is used to transmit the driving force of the axial drive section to the front brush section. The intermediate folded surface section is used to provide assistance for the transmitted driving force and to buffer the pressure on the front brush section. The front brush section is used to collect samples from the nasal cavity.

2. The soft nasal swab based on pneumatic growth according to claim 1, characterized in that, The front brush section is a spherical cavity with multiple brushes evenly distributed on its surface. The bottom of the spherical cavity is connected to the middle folded surface section, and the top of the spherical cavity is a smooth plane.

3. A soft nasal swab based on pneumatic growth according to claim 1, characterized in that, The middle folded section is a foldable cavity, which includes several layers of rings. The diameter of each ring decreases sequentially from back to front along the axial direction. When the middle folded section is squeezed by the front brush section, the multiple rings are squeezed and then overlap and shrink from front to back along the axial direction.

4. A soft nasal swab based on pneumatic growth according to claim 3, characterized in that, Each ring layer includes multiple rhomboid faces, which are spliced ​​together along the circumference to form a ring. When the middle folded section is squeezed by the front brush section, the rhomboid faces on each ring layer convert the axial force into a tangential force, and the multiple ring layers rotate and fold along the circumference.

5. A soft nasal swab based on pneumatic growth according to claim 1, characterized in that, The auxiliary support surface segment is a cylindrical cavity, with its top connected to the bottom of the middle folded surface segment and its bottom connected to the top of the axial drive segment. The axial length of the auxiliary support surface segment is H3, the axial length of the middle folded surface segment is H2, and the axial length of the front brush segment is H1, where H3 > H1 + H2.

6. A soft nasal swab based on pneumatic growth according to claim 2, characterized in that, The axial drive section is a drum-shaped cavity, which includes a top drum surface and a bottom drum surface of the same diameter. The bottom drum surface is connected to the pressurizing device through a vent pipe. After being pressurized by the pressurizing device, the axial drive section expands in the axial direction and pushes the front brush section forward.

7. A soft nasal swab based on pneumatic growth according to claim 6, characterized in that, The diameter of the top drum surface is D4, the diameter of the auxiliary support surface section is D3, the diameter of the bottom of the middle folded surface section is D22, the diameter of the top of the middle folded surface section is D21, the diameter of the brush formed on the outer edge of the front brush section is D1, and the diameter of the vent pipe is D5, where D4 > D1 > D3 = D22 > D21 > D5.

8. A soft nasal swab sampling method based on aerodynamic growth, characterized in that, The soft nasal swab according to any one of claims 1-7 comprises the following steps: S1. The subject remains still, the soft nasal swab is replaced and fixed, and the nasal swab is placed close to the lower part of the subject's nostrils by a robotic arm; S2. Start the pressurization device to inflate the soft nasal swab. After the axial drive section, auxiliary support surface section, middle folding surface section and front brush section in the nasal swab expand in sequence, the front brush section extends into the nasal cavity to prepare for sampling. S3. After the front brush segment is blocked at the sampling position inside the nasal cavity, the resistance is transmitted through the middle folded surface segment, so that the middle folded surface segment is folded down and rotated in the circumferential direction at the same time. S4. The front brush segment connected to the middle folded surface segment is driven to rotate, thereby realizing the collection of biological samples inside the nasal cavity; S5. After the nasal swab is collected, the robotic arm places the front brush section into the collection box, turns off the pressurization device, removes the soft nasal swab, and prepares for the next sampling.

9. The sampling method according to claim 8, characterized in that, Step S2 specifically includes: S21. After the axial drive section is inflated, the gas quickly enters the front brush section through the cylindrical cavity, and the front brush section extends into the nasal cavity; S22. The axial drive section and the auxiliary support section provide support for the intermediate folding section. After continuous inflation, each layer of rings in the intermediate folding section is fully unfolded. S23. As the front brush segment gradually penetrates deeper, the forward resistance gradually increases. When it reaches the sampling position inside the nasal cavity, the squeezing resistance of the front brush segment is the greatest, and this resistance is transmitted to the middle folded surface segment.

10. The sampling method according to claim 8, characterized in that, Step S3 specifically includes: S31. The top of the front brush section is a smooth plane. When it reaches the sampling position inside the nasal cavity, it encounters the greatest resistance. The smooth plane transmits the resistance axially to the top of the middle folded surface section. S32. The top of the intermediate folded surface segment transmits a portion of the resistance along the axial direction on its multi-layered rings to the bottom of the intermediate folded surface segment, and the multi-layered rings overlap along the axial direction under the action of this portion of resistance. S33. The top of the intermediate folded surface segment transmits another part of the resistance in the rhomboid surface of each ring along the tangential direction. Since the bottom of the intermediate folded surface segment is connected to the auxiliary support surface segment, the auxiliary support surface segment provides support for the bottom of the intermediate folded surface segment and prevents this part of the resistance from continuing to be transmitted along the axial direction, so that the intermediate folded surface segment rotates along the tangential circumferential direction under the action of this part of the resistance.

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