occlusion device

Abstract

The application discloses a plugging device and relates to the technical field of medical devices. The plugging device comprises a plugging body, an elastic connecting piece and a hanging component. The plugging body is adapted to the shape of a target plugging area. One end of the elastic connecting piece is arranged on the plugging body. One end of the hanging component is connected with the other end of the elastic connecting piece, and the hanging component is adapted to be hung on the tissue of the target plugging area. The plugging device for cauliflower-shaped left atrial appendages is made of degradable materials, can be implanted into the left atrial appendages of a patient through a minimally invasive catheter intervention operation to realize plugging of the left atrial appendages, can guide the climbing of the endothelial tissue in the left atrium, and can realize complete degradation of the device in the human body after endothelialization. Finally, the plugging effect is realized by the patient's autologous tissue, the formation and shedding of thrombus embolus in the left atrial appendages are effectively prevented, and the risk of stroke is greatly reduced.

Description

TECHNICAL FIELD

[0001] The present application relates to the technical field of medical devices, and in particular to a closure device. BACKGROUND

[0002] Atrial fibrillation (AF) is a common persistent arrhythmia in clinical practice, and is a common heart disease in the elderly population. The incidence of AF increases with age. One of the main hazards of AF is the induction of left atrial thrombus formation.

[0003] The left atrial appendage (LAA) is a small sac on the right front side of the left atrium. It is a structure that the heart originally has. It is the remnant of the primitive left atrium during embryonic development, but its internal structure is not quite the same as that of the mature left atrium. The LAA is not a cavity like the left atrium, but has very rich comb-shaped muscles and trabeculae, resulting in a large number of channels and recesses inside, forming a structure similar to a "honeycomb". Long-term clinical practice and research have found that the unique structure of the LAA is the main site of thrombus formation in patients with AF. The special structure of the LAA causes the blood flow to slow down in the LAA, and in extreme cases, even turbulent flow can cause some blood to stagnate and eventually clot to form a thrombus. In the LAA, the risk of blood stagnation and clotting is greatly increased due to the instability of blood flow in patients with AF, making it a "thrombus embolus base" in the patient's body. These thrombi, although formed in the LAA, still have a high risk of falling off and running with the blood to other parts of the body, causing blood vessel obstruction. When the thrombus enters the cerebral blood vessels and causes cerebral blood vessel obstruction, it can cause very serious complications of stroke.

[0004] Stroke is the main cause of long-term disability in the elderly and is the main consumer of medical resources. Stroke is a relatively fast onset and progression, which can easily cause sequelae in patients, such as limb damage and paralysis, and can cause heavy burden to patients and families. It can also cause limb paralysis and cause the patient to be unable to take care of himself. At present, most of the thrombi in non-valvular AF patients come from the LAA, and the thrombus problem in the LAA is a sword of Damocles over the heads of AF patients.

[0005] The traditional treatment regimen is to take oral anticoagulants to inhibit blood clotting to form thrombi, but long-term oral anticoagulants are expensive, have a high incidence of complications, and have poor patient compliance. Medical research has found that closing and occluding the LAA can significantly reduce the risk of thrombus formation and shedding in the LAA, and the impact on the patient's cardiac function is within a controllable range, which is an ideal stroke prevention regimen and can greatly reduce the risk of cardiogenic stroke. Compared with direct thoracotomy for LAA ligation surgery, the surgical regimen of the LAA occlusion device through catheter intervention has the advantages of small incision, low risk, and less pain for patients, and is a new generation of treatment regimen that has emerged in recent years and is popular in the medical market.

[0006] Most of the left atrial appendage occlusion devices on the market are composed of metal and attached with a flow blocking film, adopting an umbrella or cover type configuration, which has strong universality, but poor adaptability to cauliflower-shaped left atrial appendage, and poor occlusion effect. The cauliflower-shaped left atrial appendage has a higher incidence of stroke, which is significantly higher than that of other shapes of left atrial appendage. SUMMARY

[0007] The main purpose of the present application is to provide an occlusion device, which aims to improve the occlusion effect of the occlusion device, especially the occlusion effect of the cauliflower-shaped left atrial appendage.

[0008] To achieve the above-mentioned purpose, the present application provides an occlusion device, which comprises:

[0009] An occlusion body adapted to the shape of the target occlusion area;

[0010] An elastic connecting piece, one end of which is arranged on the occlusion body; and

[0011] A hanging component, one end of which is connected with the other end of the elastic connecting piece, and the hanging component is adapted to be hung on the tissue of the target occlusion area.

[0012] Optionally, the occlusion body is disc-shaped, and the elastic connecting piece is spring-shaped;

[0013] The diameter of the elastic connecting piece is smaller than the diameter of the occlusion body; and / or

[0014] The diameter of the elastic connecting piece is 14-32mm, and the length is 8-15mm; and / or

[0015] The diameter of the occlusion body is 20-40mm.

[0016] Optionally, the occlusion device further comprises a filling component, which is arranged in the elastic connecting piece and connected with the occlusion body, and the filling component is used to fill the internal space of the target occlusion area and provide radial support force for the elastic connecting piece.

[0017] Optionally, the filling component is a structure that is at least partially compressed and can spontaneously expand in liquid; and / or

[0018] The occlusion body is a structure that is at least partially compressed and can spontaneously expand in liquid.

[0019] Optionally, the occlusion body is made of a medical degradable material; and / or

[0020] The elastic connecting piece is made of a medical degradable material; and / or

[0021] The hanging component is made of a medical degradable material; and / or

[0022] The filling component is made of a medical degradable material.

[0023] Optionally, the material of the occlusion body is expandable polyurethane foam; and / or

[0024] The material of the elastic connecting piece is random poly-lactic acid, poly-p-dioxanone, poly-l-lactide-co-DL-lactide, a medical degradable magnesium alloy or a zinc alloy, or the elastic connecting piece is a composite structure formed by filling a hollow metal tube with a degradable polymer material; and / or

[0025] The material of the hanging component is L-lactic acid, poly-caprolactone, poly-l-lactide-co-DL-lactide, a medical degradable magnesium alloy or a zinc alloy, or the hanging component is a composite structure formed by filling a hollow metal tube with a degradable polymer material; and / or

[0026] The material of the filling component is expandable polyurethane foam, or the filling component is a composite structure formed by wrapping an expandable polyurethane foam around a hard center rod.

[0027] Optionally, the elastic connecting piece is provided with a plurality of barb portions for penetrating into the tissue of the target occlusion area.

[0028] Optionally, the height difference between the center and the edge of the disc surface of the occlusion body is 1-4 mm, and the slope is 5-15°.

[0029] Optionally, the filling component has one or more, and a plurality of the filling components are connected in series.

[0030] Optionally, the elastic connecting piece and the occlusion body, and the elastic connecting piece and the hanging component are fixed by crimping or welding; and / or

[0031] The hanging component is provided with a connecting hole adapted to be connected to the end of a pushing device.

[0032] In the technical scheme of the present application, the occlusion device comprises an occlusion body, an elastic connecting piece and a hanging component; the occlusion body is adapted to the shape of the target occlusion area; one end of the elastic connecting piece is arranged on the occlusion body; one end of the hanging component is connected with the other end of the elastic connecting piece, and the hanging component is adapted to be hung on the tissue of the target occlusion area. It can be understood that the occlusion device for the cauliflower-shaped left atrial appendage of the present application can be implanted into the left atrial appendage of the patient through a minimally invasive catheter intervention surgery to achieve the occlusion of the left atrial appendage and guide the overgrowth of the endothelial tissue in the left atrium, and the occlusion effect is greatly improved; and the occlusion device is made of degradable material, which can realize complete degradation of the endothelialization instrument in the human body, and finally completely realizes the occlusion effect by the patient's autologous tissue, effectively prevents the formation and shedding of thrombus embolus in the left atrial appendage, and greatly reduces the risk of stroke. BRIEF DESCRIPTION OF DRAWINGS

[0033] In order to more clearly illustrate the technical scheme in the embodiments of the present application or the prior art, the drawings needed to be used in the following embodiment or prior art description will be briefly introduced. Obviously, the drawings in the following description are only some embodiments of the present application, and other drawings can be obtained by those skilled in the art without creative labor on the basis of the drawings shown.

[0034] Figure 1 It is an embodiment of the structure of the occlusion device of the present application.

[0035] Figure 2 It is a front view of an embodiment of the occlusion device of the present application.

[0036] Figure 3 It is a top view of an embodiment of the occlusion device of the present application.

[0037] Figure 4 It is a top view of another embodiment of the occlusion device of the present application.

[0038] Figure 5 It is a structure diagram of the filling component in another embodiment of the occlusion device of the present application.

[0039] Figure 6 It is a wire structure diagram of the elastic connecting piece in an embodiment of the occlusion device of the present application.

[0040] Figure 7 It is a wire structure diagram of the elastic connecting piece in another embodiment of the occlusion device of the present application.

[0041] Explanation of reference numerals:

[0042] 10, occlusion body; 20, elastic connecting piece; 30, hanging component; 40, filling component; 311, braided wire; 312, coiled wire.

[0043] The objectives, functional characteristics and advantages of the present application will be further described with reference to the embodiments and the accompanying drawings. DETAILED DESCRIPTION

[0044] The technical solutions in the embodiments of the present application will be clearly and completely described with reference to the accompanying drawings in the embodiments of the present application. Obviously, the described embodiments are only part of the embodiments of the present application, rather than all the embodiments of the present application. Based on the embodiments in the present application, all the other embodiments obtained by a person of ordinary skill in the art without creative effort are within the protection scope of the present application.

[0045] It should be noted that all the directionality indications (such as up, down, left, right, front, back, etc.) in the embodiments of the present application are only used to explain the relative position relationship, movement condition, etc. between components in a certain posture (as shown in the drawings), and if the certain posture changes, the directionality indications also change accordingly.

[0046] In the description of the present application, it should be noted that unless otherwise explicitly specified and limited, the terms “mounting”, “connection”, “connecting” should be understood in a broad sense, for example, can be fixed connection, can be detachable connection, or integral connection; can be mechanical connection, can be electrical connection; can be direct connection, can be indirect connection through an intermediate medium, can be the communication inside two elements. For a person of ordinary skill in the art, the specific meaning of the above terms in the present application can be understood according to the specific circumstances.

[0047] In addition, the description of “first”, “second” and the like in the present application is only for the purpose of description, and cannot be understood as indicating or implying the relative importance of the indicated technical features or implicitly indicating the number of the indicated technical features. Therefore, the features limited by “first”, “second” can explicitly or implicitly include at least one of the features. In addition, the meaning of “and / or” appearing throughout the text is to include three parallel schemes, for example, “A and / or B” includes A scheme, or B scheme, or A and B schemes are satisfied at the same time. In addition, the technical solutions of each embodiment can be combined with each other, but it must be based on the fact that a person of ordinary skill in the art can realize it, when the combination of technical solutions appears contradictory or unachievable, it should be considered that the combination of technical solutions does not exist, and is not within the protection scope of the present application.

[0048] A medical study shows that the left atrial appendage of human can be divided into four shapes, namely chicken wing shape, cactus shape, wind direction bag shape and cauliflower shape, and the four types account for 48%, 30%, 19% and 3% respectively. Related studies also show similar results. Although the cauliflower-shaped left atrial appendage only accounts for a small part of the population (3%), it has a very high incidence of stroke, significantly higher than the other three, and is an independent factor for left atrial thrombosis. Moreover, the cauliflower-shaped left atrial appendage is also shorter in length, and there are many problems and risks in the fixation of the current occlusion device.

[0049] To this end, the present application provides a sealing device, which can be applied to seal the blood vessels or heart of human or animal body, especially for sealing the cauliflower-shaped left atrial appendage.

[0050] Reference Figures 1 to 3 In an embodiment of the present application, the sealing device comprises a sealing body 10, an elastic connecting piece 20 and a hanging component 30; the sealing body 10 is adapted to the shape of the target sealing area; one end of the elastic connecting piece 20 is arranged on the sealing body 10; the other end of the elastic connecting piece 20 is connected with one end of the hanging component 30, and the hanging component 30 is adapted to be hung on the tissue of the target sealing area.

[0051] In this embodiment, the sealing body 10 can be disc-shaped to adapt to the structure of the cauliflower-shaped left atrial appendage, which is not limited. The elastic connecting piece 20 can be spring-shaped or the like, so that the hanging component 30 has a wider hanging range, which helps to enhance the hanging reliability. The hanging component 30 can be a hook or a hanging structure with multiple hooks, which is not limited.

[0052] The head hook of the hanging component 30 can hook the pectinate muscle inside the left atrial appendage; the disc-shaped sealing body 10 has a certain flow resistance effect and can be fixed at the left atrial appendage passage to block the blood flow, preventing the blood from flowing into or out of the left atrial appendage; the spring-shaped elastic connecting piece 20 can connect the two parts and has a smaller relaxed annular diameter than the sealing body 10, and when stretched by external force, it can be stretched into a long strip shape, and after the external force is removed, it can automatically recover to the original spring shape.

[0053] To achieve better sealing effect of the cauliflower-shaped left atrial appendage, preferably, the diameter of the elastic connecting piece 20 is smaller than the diameter of the sealing body 10; specifically, the diameter of the elastic connecting piece 20 can be 14-32mm, and the length can be 8-15mm; the diameter of the sealing body 10 can be 20-40mm. In this embodiment, the height difference between the center and the edge of the disc surface of the sealing body 10 can be set to 1-4mm, and the slope can be set to 5-15°, which is not limited.

[0054] It can be understood that the occlusion device for cauliflower-shaped left atrial appendage of the present application can be implanted into the left atrial appendage of the patient through minimally invasive catheter intervention surgery to achieve occlusion of the left atrial appendage and guide the endothelialization of the left atrium, greatly improving the occlusion effect. Moreover, the occlusion device is made of degradable material, which can completely degrade in the human body after endothelialization, and finally completely occlude the effect by the patient's autologous tissue, effectively preventing the formation and shedding of left atrial thrombus embolus, greatly reducing the risk of stroke.

[0055] To further improve the occlusion effect of the occlusion device, refer to Figures 1 to 5 In some embodiments, the occlusion device can further include a plugging component 40, which can be in the form of a rod, etc. The plugging component 40 is arranged in the elastic connecting member 20 and connected with the occlusion body 10. The plugging component 40 is used to plug the internal space of the target occlusion area and provide radial support force for the elastic connecting member 20. That is, the plugging component 40 has a compressed self-expandable part that can spontaneously expand to a certain volume in blood.

[0056] In this embodiment, mainly refer to Figures 3 to 5 The plugging component 40 has one or more, and the multiple plugging components 40 are connected in series. The specific design can be made according to the processing and assembly difficulty, manufacturing cost, convenience of operation and specific occlusion scene, etc. Herein, no limitation is made.

[0057] When the occlusion device contains only a single plugging component 40, the expansion diameter of the plugging component 40 should be set to be greater than the spring inner ring diameter of the elastic connecting member 20. When the occlusion device contains multiple plugging components 40, the expansion diameter of a single plugging component 40 can be less than the spring inner ring diameter of the elastic connecting member 20.

[0058] In this embodiment, the plugging component 40 is at least partially compressed and can spontaneously expand in liquid. Similarly, the occlusion body 10 is at least partially compressed and can spontaneously expand in liquid.

[0059] Further, the occlusion body 10 can be made of a medical degradable material; the elastic connecting member 20 can be made of a soft medical degradable material; the hanging component 30 can be made of a hard medical degradable material; and the plugging component 40 can be made of a medical degradable material.

[0060] The material of the plugging body 10 is expandable polyurethane foam; the material of the elastic connecting piece 20 is random poly-lactic acid, poly-p-dioxanone, poly-glycolide, medical degradable magnesium alloy or zinc alloy, or the elastic connecting piece 20 is a composite structure formed by filling a hollow metal tube with degradable polymer material; the material of the hooking component 30 is left-handed poly-lactic acid, poly-caprolactone, poly-glycolide, medical degradable magnesium alloy or zinc alloy, or the hooking component 30 is a composite structure formed by filling a hollow metal tube with degradable polymer material; the material of the filling component 40 is expandable polyurethane foam, or the filling component 40 is a composite structure formed by wrapping a hard center rod with expandable polyurethane foam.

[0061] The plugging body 10 is made of expandable polyurethane foam material, has only a small volume in the compressed state, and can expand within 1-10 minutes after encountering water, with the volume being expanded to 10-200 times that in the compressed state. In the compressed state, the degradable polyurethane material is folded and compressed into a long columnar shape according to a certain folding mode, can be delivered into the human body through a surgical sheath, and the center of the long column can allow the head end of the pushing device to enter. The expanded polyurethane foam forms a circular disc with a certain diameter and thickness, and the center and the edge of the disc are not in the same plane to form a conical shape with a small slope.

[0062] The hooking component 30 can be processed into the shape of a hook through the above-mentioned materials, has a hardness capable of piercing the inner membrane of the heart tissue, and also has a certain elasticity capable of bearing a certain limit of extrusion deformation and still recovering to more than 90% of the original shape. When the hooking component 30 is a composite structure formed by filling a hollow metal tube with degradable polymer material, the metal shell can provide a relatively strong hardness and elasticity in the early stage, and the internal degradable polymer material can provide long-term mechanical strength, so as to avoid the problem that the degradable metal material degrades too fast and the mechanical properties cannot be maintained for a long time.

[0063] The size and curvature of the hooking component 30 should be designed to have a certain matching with the comb-shaped muscle inside the cauliflower-shaped left atrial appendage, can provide strong puncture ability and elastic support ability, can hook the comb-shaped muscle at the distal end of the left atrial appendage when deep into the left atrial appendage, and be fixed in the comb-shaped muscle channel or recess in the left atrial appendage for a long time (at least three months). The hook has strong elasticity, can be appropriately straightened and recover the curvature, can be compressed and loaded into the catheter without affecting the delivery of the device, and after being sent out of the catheter, will recover to the original size and curvature from the appropriately straightened state under the action of self-elasticity, so as to realize the hooking and fixing of the comb-shaped muscle at the distal end of the left atrial appendage.

[0064] In this embodiment, the elastic connecting member 20 can be provided with a plurality of barbs for penetrating into the tissue of the target occlusion area. This helps to further improve the reliability of the connection between the occlusion device and the human tissue, and further enhances the occlusion effect. The barbs can be barb structures formed by processing the elastic connecting member 20 itself, or can be hooks attached additionally.

[0065] The elastic connecting member 20 can be processed into a linear shape by the aforementioned materials to become a degradable wire. The wire can be processed to have barbs on the wire, which can pierce the endocardium and play a partial fixation role. As shown in Figure 6 and Figure 7 The elastic connecting member 20 can use a braided wire 311 or a coiled wire 312. The spring-like member can be directly prepared by coiling the wire, or can be prepared by braiding multiple wires and then coiling, or can be prepared by first spirally coiling the wire into a slender steel cable and then coiling. The length and diameter of the coiled spring are matched with the typical clinical size of the left atrial appendage. Preferably, the diameter of the coiled spring is in the range of 14-32 mm, and the length is in the range of 8-15 mm.

[0066] During processing, the thicker degradable wire can be directly coiled into a large spring, or the thinner degradable wire can be first coiled into a slender spring and then coiled into a large spring, or multiple wires can be braided into a braided wire and then coiled into a large spring. Preferably, the diameter of the degradable wire or the thin spring made of the degradable wire should be smaller than the inner diameter of the catheter used in the catheter intervention surgery. The degradable wire can have a multi-layer composite structure, or can have a certain design pattern, groove, etc. to facilitate its elastic bending. During the processing of the barbs, a roller can be used to roll and process the barbs, or a laser cutting method can be used to set the laser parameters such as power, pulse frequency, cutting speed, etc. according to the angle, size, and spacing of the barbs to ensure the formation of effective barb structures.

[0067] The plug-in member 40 is made of a medical degradable material and has an expandable property. It is compressed into a vertical strip shape in vitro and can spontaneously expand radially within a certain time after contacting and absorbing blood. It can be made of a single expandable polyurethane foam material, or a thin hard center rod wrapped with an expandable polyurethane foam material. The composite structure is beneficial to improve the connection strength of the structure. The plug-in connecting rod can be used alone or in series. It expands to a set size in vivo and has the effect of plugging the internal space of the left atrial appendage and providing radial support for the spring ring.

[0068] In addition, the size of the occlusion body 10 and the length and diameter of the elastic connecting member 20 are designed to have optional different models to cope with different sizes and depths of the cauliflower-shaped left atrial appendage.

[0069] It should be noted that most of the left atrial appendage occlusion devices currently on the market are made of metal and have a flow-blocking membrane. They adopt an umbrella or cap-type configuration and are highly versatile, but there are still many problems such as metal ion leakage, metal fatigue, and metal implants affecting CT and MRI detection.

[0070] The implantable occlusion device made of biodegradable material provided by this invention can provide flow obstruction and support in the early stage of implantation, and provide a bridge for endothelial tissue to climb over. After completing its occlusion mission, it gradually degrades and is replaced by autologous tissue, achieving the goal of complete occlusion by autologous tissue, which is in line with the health concept of "intervention without implantation and implantation without residue".

[0071] To ensure the reliability of the connections between the components and thus guarantee the sealing stability of the sealing device, refer to... Figure 1 and Figure 2 In one embodiment, the elastic connector 20 and the sealing body 10, as well as the elastic connector 20 and the hanging component 30, are fixed by means of upper and lower pressure plate pressing or hot-melt pressing. More specifically, when the hanging component 30 is metal or has a metal outer layer, it can be joined by pressure plate pressing; when the hanging component 30 is made of all polymer material, it can be fixed by pressure plate welding to achieve a better fixing effect.

[0072] In this embodiment, the hook-on component 30 is provided with a connection hole suitable for connecting and adapting to the end of the pushing device. The connection hole can be a threaded hole or the like, and is not limited here.

[0073] During the procedure, the occlusion body 10 and the packing component 40 are in a compressed state. The pushing device is connected to the occlusion device, and only the occlusion body 10 is pulled into the loader for rapid venting to remove gas from the instrument delivery system and prevent air embolism (a clinical complication that can lead to patient death). The elastic connector 20 is stretched, and the hook component 30 is inserted into the sheath and pushed. The hook component 30 is released distally to attempt to hook the distal pectinate muscle. Then, the elastic connector 20 is gradually pushed, allowing it to naturally return to a spring shape within the left atrial appendage. Due to its good elasticity, it can adapt to the shape of the left atrial appendage. After this, a traction test can be used to confirm the stability of the attachment. After confirming stability, the loader is connected to the outer sheath, and the pushing delivery device pushes forward to release the packing components 40 one by one. The packing components 40 are allowed to expand and fill the space within the atrial appendage. Then, the umbrella-shaped portion of the occlusion body 10 is pushed out, and the polyurethane is allowed to expand into a roughly conical disc. The residual shunt is then confirmed with instrument assistance. After there is no residual shunt, twisting the pusher will separate the pusher from the instrument, completing the release.

[0074] The above description is merely an optional embodiment of the present invention and does not limit the patent scope of the present invention. All equivalent structural transformations made using the contents of the present invention's specification and drawings under the inventive concept of the present invention, or direct / indirect applications in other related technical fields, are included within the patent protection scope of the present invention.

Claims

1. A sealing device, characterized in that, The sealing device includes: The sealing body is adapted to fit the shape of the target sealing area, the sealing body is disc-shaped, and the sealing body is a structure that is at least partially compressible and can spontaneously expand in a liquid; An elastic connector, one end of which is disposed on the sealing body, is spring-shaped; A mounting component, one end of which is connected to the other end of the elastic connector, the mounting component being adapted to be attached to the tissue of the target occlusion region; and A plugging component, which is at least partially compressible and spontaneously expandable in a liquid, is disposed within the elastic connector and connected to the plugging body. The plugging component is used to fill the internal space of the target plugging area and provide radial support force for the elastic connector.

2. The sealing device as described in claim 1, characterized in that, The diameter of the elastic connector is smaller than the diameter of the sealing body; and / or The elastic connector has a diameter of 14-32 mm and a length of 8-15 mm; and / or The diameter of the sealing body is 20-40mm.

3. The sealing device as described in claim 2, characterized in that, The sealing body is made of medical biodegradable material; and / or The elastic connector is made of medical-grade biodegradable material; and / or The mounting components are made of medical-grade biodegradable materials; and / or The filling component is made of medical-grade biodegradable material.

4. The sealing device as described in claim 3, characterized in that, The sealing body is made of expandable polyurethane foam; and / or The elastic connector is made of random polylactic acid, poly(p-dioxanone), hexyl lactide copolymer, medical biodegradable magnesium alloy, or zinc alloy; or the elastic connector is a composite structure formed by filling a hollow metal tube with a biodegradable polymer material; and / or The material of the mounting component is polylactic acid (PLA), polycaprolactone (PVC), hexyl lactide copolymer, medical biodegradable magnesium alloy, or zinc alloy; or the mounting component is a composite structure formed by filling a hollow metal tube with a biodegradable polymer material; and / or The filling component is made of expandable polyurethane foam, or the filling component is a composite structure in which a rigid central rod is wrapped with expandable polyurethane foam.

5. The sealing device as described in claim 1, characterized in that, The elastic connector is provided with a plurality of barbs, which are used to penetrate into the tissue of the target sealing area.

6. The sealing device as described in claim 2, characterized in that, The height difference between the center and the edge of the sealing body is 1-4mm, and the slope is 5-15°.

7. The sealing device as described in claim 1, characterized in that, The filling component has one or more components, and the plurality of filling components are connected in series.

8. The sealing device as described in claim 1, characterized in that, The elastic connector and the sealing body, and the elastic connector and the hanging component are all fixed by compression or welding; and / or The mounting component is provided with a connection hole suitable for connecting and fitting with the end of the pushing device.

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