A kind of mouthwash with effective anti-moth function and preparation method thereof

Abstract

The invention relates to the technical field of oral care, and in particular to an effective anti-caries mouthwash and a preparation method thereof; the effective anti-caries mouthwash is composed of the following percentage components: 0.1-0.5% sodium fluoride, 0.1-0.5% sodium monofluorophosphate, 0.1-0.5% olafluan, 0.5-1% hydroxyapatite, 0.5-1% lactobacillus, 0.5-1.5% green tea extract, 0.5-1.5% honeysuckle extract, 1.5-2% menthol, 0.5-1% lemon The invention comprises the following components: sodium iodide, 2-3% honey, 1.5-3% licorice extract, 0.5-1.5% lemon extract, 0.5-1.5% ascorbic acid, 2-3% polyoxyethylene hydrogenated eucalyptus oil and water as the balance; the invention has an excellent anti-caries effect, can enhance tooth resistance and inhibit tooth caries, and has excellent ductility and comprehensive protection properties, can quickly cover and fully wrap the tooth surface, can inhibit the growth of bacteria in the oral cavity, reduce the risk of tooth infection and provide a long-term anti-caries effect.

Description

Technical Field

[0001] The invention relates to the technical field of oral care, and in particular to an effective anti-caries mouthwash and a preparation method thereof. Background Art

[0002] Mouthwash is a daily oral care product widely used to clean the mouth, remove bad breath, prevent tooth decay and improve oral hygiene. People first used various plants, spices and water to rinse their mouths to keep their breath fresh and prevent oral diseases. With the development of science, mouthwash gradually entered the commercial market. The earliest commercial mouthwash usually contained ingredients such as acetic acid and alcohol, which were used to clean the mouth and remove bad breath. However, these early products were highly irritating and had limited effects.

[0003] Chinese patent publication number CN111494409A discloses a multifunctional medical mouthwash and a preparation method thereof, which uses nimesulide and sodium fluoride to clean the oral cavity and relieve oral discomfort symptoms, thereby enhancing the applicability of the mouthwash, but its anti-caries effect is poor; Chinese patent publication number CN110538134A discloses a mouthwash and a low-viscosity solution, which adds probiotics into the mouthwash to effectively solve the problem of bad breath, but its antiseptic performance is poor and its high and low temperature stability is poor.

[0004] In view of the above technical defects, a solution is now proposed. Summary of the invention

[0005] The purpose of the present invention is to provide an effective anti-caries mouthwash and a preparation method thereof. The mouthwash prepared by the present invention can not only effectively prevent tooth decay but also protect tooth enamel from wear and tear and control oral halitosis.

[0006] To achieve the above-mentioned purpose, the present invention adopts the following technical scheme: an effective anti-caries mouthwash is composed of the following percentage ingredients: 0.1-0.5% sodium fluoride, 0.1-0.5% sodium monofluorophosphate, 0.1-0.5% olafluan, 0.5-1% hydroxyapatite, 0.5-1% lactobacillus, 0.5-1.5% green tea extract, 0.5-1.5% honeysuckle extract, 1.5-2% menthol, 0.5-1% sodium citrate, 2-3% honey, 1.5-3% licorice extract, 0.5-1.5% lemon extract, 0.5-1.5% ascorbic acid, 2-3% polyoxyethylene hydrogenated eucalyptus oil and the balance water;

[0007] The preparation method of polyoxyethylene hydrogenated eucalyptus oil comprises the following steps:

[0008] A1: Add eucalyptus oil to a blender, place the blender in a fume hood, turn on the fume hood ventilation, set the wind speed to 1.5-2m / s, turn on the blender, set the speed to 600-800rpm, and blend for 1.5-2h. Transfer the blended eucalyptus oil to a homogenizer, and homogenize for 30min to obtain homogenized eucalyptus oil.

[0009] A2: Add the homogenized eucalyptus oil to an oscillator. Before adding, use a vacuum pump to extract the air in the oscillator to create a vacuum environment. Then connect the air inlet valve on the oscillator to a high-pressure nitrogen bottle, use nitrogen to protect the reaction system, fill with nitrogen, and make the air pressure in the oscillator 0.95-1.12atm. Then close the upper air inlet valve, and then change the valve on the oscillator to connect to the hydrogen generator. At the same time, open the upper air inlet valve and the oscillator pump. Open the lower air outlet valve every 10 minutes, use a vacuum pump to extract 10% nitrogen and hydrogen mixed gas. During the vacuum pump extraction process, adjust the upper air inlet valve and the lower air outlet valve to keep the pressure in the oscillator at 0.95-1.12atm. After 100 minutes, close the upper air inlet valve and the lower air outlet valve, and at the same time close the hydrogen generator and the vacuum pump. After oscillating for 2 hours, end the oscillation process to obtain hydrogenated eucalyptus oil.

[0010] A3: Transfer the hydrogenated eucalyptus oil to a high-pressure reactor, adjust the speed of the magnetic stirrer to 1200-1500 rpm and the temperature to 45-50°C, add polyoxyethylene and a metal catalyst, connect the air inlet of the high-pressure reactor to a high-pressure nitrogen bottle, use nitrogen to protect the reaction system, fill the reactor with nitrogen to a pressure of 2.1-2.4 atm, and stir the reaction for 30-60 minutes;

[0011] A4: The eucalyptus oil after the reaction is transferred to a distillation tower for heating and distillation. The temperature in the distillation tower is adjusted to 200-240°C and the distillation pressure is 0.3-0.6atm. The distillation is carried out for 5-6 hours, and the upper layer product of the distillation tower is collected and re-added to the agitator, and steps A1-A3 are repeated once or twice. The bottom layer product of the distillation tower is collected to obtain polyoxyethylene hydrogenated eucalyptus oil.

[0012] Furthermore, the metal catalyst described in step A3 is obtained by adding CaO and EDTA to pure ethanol in a ratio of 1:1 and stirring, then adding MnO and NiO in a mass ratio of n(MnO):n(CaO):n(EDTA):n(NiO)=1:1:1:1, ultrasonically dispersing until completely dissolved, and then calcining at 230-245°C in a muffle furnace for 1-1.5h, then transferring the calcined product to a drying oven, adjusting the drying oven temperature to 65°C, the wind speed to 1.5-2m / s, and drying for 30-45min; the mass ratio of hydrogenated eucalyptus oil, polyoxyethylene and metal catalyst in step A3 is 6:3:1;

[0013] Further, a method for preparing an effective anti-caries mouthwash comprises the following steps:

[0014] B1: Sodium fluoride, sodium monofluorophosphate, olafluor, polyoxyethylene hydrogenated eucalyptus oil and hydroxyapatite were added into a reaction kettle and mixed, and stirred with a magnetic stirrer at 25° C. and 600-800 rpm for 30 min to obtain product A;

[0015] B2: Add green tea extract, honeysuckle extract, lemon extract and ascorbic acid into pure water for dissolution, and stir with a magnetic stirrer at 35-40°C and 800-1000 rpm for 30 min to obtain product B;

[0016] B3: Mix product A and product B in a reactor, then add lactobacillus, menthol, sodium citrate, honey and licorice extract, then add pure water, set the stirrer speed to 1200-1500 rpm and mix for 45-60 minutes to obtain an effective anti-caries mouthwash.

[0017] Furthermore, the lactobacillus is Lactobacillus reuteri, with a specification of 90-110 cfu / g; the lemon extract is water-soluble lemon powder, with a specification of 10:1; the honeysuckle extract is water-soluble honeysuckle pollen, with a specification of 10:1; the green tea extract is water-soluble green tea powder, with a specification of 20:1; the licorice extract is water-soluble Glycyrrhiza glabra root extract, with a specification of 20:1; the hydroxyapatite is white powdery basic calcium phosphate with a particle size of 5-20 um; the sodium monofluorophosphate is water-soluble sodium monofluorophosphate, with a specification of 10:1.

[0018] In summary, due to the adoption of the above technical scheme, the beneficial effect of the present invention is that the present invention can enhance the resistance of tooth enamel to organic acids produced by oral microorganisms by reducing the solubility of tooth enamel, and has an excellent anti-caries effect. At the same time, the present invention will react with the crystals on the surface of tooth enamel to generate fluoroapatite, thereby enhancing the resistance of teeth and inhibiting caries. The present invention has excellent ductility and comprehensive protection characteristics, can quickly cover and fully wrap the tooth surface, can inhibit the growth of bacteria in the oral cavity, reduce the risk of tooth infection, and provide a long-term anti-caries effect. DETAILED DESCRIPTION

[0019] In order to make the technical means, creative features, objectives and effects achieved by the present invention easy to understand, the present invention is further described below in conjunction with specific embodiments.

[0020] The experimental methods in the following examples, unless otherwise specified, are conventional methods, and are performed according to the techniques or conditions described in the literature in the field or according to the product instructions. The materials and reagents used in the following examples, unless otherwise specified, can be obtained from commercial channels.

[0021] Example 1

[0022] 1: Add 200g of eucalyptus oil to the blender, place the blender in a fume hood, turn on the fume hood ventilation, set the wind speed to 2m / s, turn on the blender, set the speed to 800rpm, and stir for 2h. Transfer the stirred eucalyptus oil to a homogenizer and homogenize for 30min to obtain 175g of homogenized eucalyptus oil.

[0023] 2: Add the homogenized eucalyptus oil to the oscillator. Before adding, use a vacuum pump to extract the air in the oscillator to create a vacuum environment. Then connect the air inlet valve on the oscillator to a high-pressure nitrogen bottle, use nitrogen to protect the reaction system, fill with nitrogen, and make the air pressure in the oscillator 1.12atm. Then close the upper air inlet valve, and then change the valve on the oscillator to connect the hydrogen generator and open the upper air inlet valve and the oscillator pump at the same time. Open the lower air outlet valve every 10 minutes, use a vacuum pump to extract 10% nitrogen and hydrogen mixed gas, adjust the upper air inlet valve and the lower air outlet valve during the vacuum pump extraction process, so that the pressure in the oscillator is maintained at 1.12atm. After 100 minutes, close the upper air inlet valve and the lower air outlet valve, and at the same time close the hydrogen generator and the vacuum pump. After continuous oscillation for 2 hours, end the oscillation process to obtain 180g of hydrogenated eucalyptus oil;

[0024] 3: Add 20g CaO and 20g EDTA to pure ethanol and stir, then add 20g MnO and 20g NiO, then transfer the product to an ultrasonic oscillator and disperse it by ultrasonic until it is completely dissolved; transfer the product after ultrasonication to a muffle furnace and calcine it at 245°C for 1.5h, then transfer the calcined product to a drying oven, adjust the temperature of the drying oven to 65°C, the wind speed to 2m / s, and dry it for 45min to obtain 60g of metal catalyst;

[0025] 4: Transfer 180g of hydrogenated eucalyptus oil to a high-pressure reactor, adjust the speed of the magnetic stirrer to 1500rpm, the temperature to 50°C, add 90g of polyoxyethylene and 30g of a metal catalyst, connect the air inlet of the high-pressure reactor to a high-pressure nitrogen bottle, use nitrogen to protect the reaction system, fill the reactor with nitrogen to a pressure of 2.4atm, and stir the reaction for 60min;

[0026] 5: The eucalyptus oil after the reaction is transferred to a distillation tower for heating and distillation. The temperature in the distillation tower is adjusted to 240°C and the distillation pressure is 0.6 atm. The distillation is carried out for 6 hours, and the upper layer product of the distillation tower is collected and re-added to the agitator, and steps A1-A3 are repeated once. The bottom layer product of the distillation tower is collected to obtain 140 g of polyoxyethylene hydrogenated eucalyptus oil.

[0027] Table 1, reagent parameters used in Example 1

[0028] Drug Name source model parameter Eucalyptus Oil Jiangxi Hongyuan Shengtai Biotechnology Co., Ltd. QYST 1kg Polyoxyethylene Guangzhou Zhengqian Chemical Co., Ltd. PEG-14M 1kg

[0029] Example 2

[0030] 1: Add 130 g of eucalyptus oil to a blender, place the blender in a fume hood, turn on the fume hood ventilation, set the wind speed to 1.5 m / s, turn on the blender, set the speed to 600 rpm, stir for 1.5 h, transfer the stirred eucalyptus oil to a homogenizer, homogenize for 30 min to obtain 117 g of homogenized eucalyptus oil;

[0031] 2: Add the homogenized eucalyptus oil to the oscillator. Before adding, use a vacuum pump to extract the air in the oscillator to create a vacuum environment. Then connect the air inlet valve on the oscillator to a high-pressure nitrogen bottle, use nitrogen to protect the reaction system, fill with nitrogen, and make the air pressure in the oscillator 0.95atm. Then close the upper air inlet valve, and then change the valve on the oscillator to connect the hydrogen generator and open the upper air inlet valve and the oscillator pump at the same time. Open the lower air outlet valve every 10 minutes, use a vacuum pump to extract 10% nitrogen and hydrogen mixed gas, adjust the upper air inlet valve and the lower air outlet valve during the vacuum pump extraction process, so that the pressure in the oscillator is maintained at 0.95atm. After 100 minutes, close the upper air inlet valve and the lower air outlet valve, and at the same time close the hydrogen generator and the vacuum pump. After continuous oscillation for 2 hours, end the oscillation process to obtain 120g of hydrogenated eucalyptus oil;

[0032] 3: Add 20g CaO and 20g EDTA to pure ethanol and stir, then add 20g MnO and 20g NiO, then transfer the product to an ultrasonic oscillator and disperse it by ultrasonic until it is completely dissolved; transfer the product after ultrasonication to a muffle furnace and calcine it at 230°C for 1h, then transfer the calcined product to a drying oven, adjust the temperature of the drying oven to 65°C, the wind speed to 1.5m / s, and dry it for 30min to obtain 60g of metal catalyst;

[0033] 4: Transfer 120g of hydrogenated eucalyptus oil to a high-pressure reactor, adjust the speed of the magnetic stirrer to 1500rpm, the temperature to 45°C, add 60g of polyoxyethylene and 20g of a metal catalyst, connect the air inlet of the high-pressure reactor to a high-pressure nitrogen bottle, use nitrogen to protect the reaction system, fill the reactor with nitrogen to a pressure of 2.1atm, and stir the reaction for 30min;

[0034] 5: The eucalyptus oil after the reaction is transferred to a distillation tower for heating and distillation. The temperature in the distillation tower is adjusted to 200°C and the distillation pressure is 0.3 atm. The distillation is carried out for 6 hours, and the upper layer product of the distillation tower is collected and re-added to the agitator, and steps A1-A3 are repeated twice. The bottom layer product of the distillation tower is collected to obtain 85 g of polyoxyethylene hydrogenated eucalyptus oil.

[0035] Table 2, reagent parameters used in Example 2

[0036] Drug Name source model parameter Eucalyptus Oil Jiangxi Hongyuan Shengtai Biotechnology Co., Ltd. QYST 1kg Polyoxyethylene Guangzhou Zhengqian Chemical Co., Ltd. PEG-14M 1kg

[0037] Example 3

[0038] 1: 1 g of sodium fluoride, 1 g of sodium monofluorophosphate, 1 g of olafluor, 6 g of the polyoxyethylene hydrogenated eucalyptus oil prepared in Example 1 and 2 g of hydroxyapatite were added into a reaction kettle and mixed, and stirred with a magnetic stirrer at 25° C. and 800 rpm for 30 min to obtain product A;

[0039] 2: 3 g of green tea extract, 3 g of honeysuckle extract, 3 g of lemon extract and 3 g of ascorbic acid were dissolved in 100 g of pure water, and stirred with a magnetic stirrer at 40° C. and 1000 rpm for 30 min to obtain product B;

[0040] 3: Product A and product B were mixed and stirred in a reactor, followed by adding 2 g of lactobacillus, 4 g of menthol, 2 g of sodium citrate, 6 g of honey and 6 g of licorice extract, followed by adding 57 g of pure water, setting the stirrer speed to 1500 rpm and mixing and stirring for 60 min to obtain 200 g of an effective anti-caries mouthwash prepared in Example 4.

[0041] Table 3, reagent parameters used in Example 3

[0042]

[0043]

[0044] Example 4

[0045] 1: 0.2 g of sodium fluoride, 0.2 g of sodium monofluorophosphate, 0.2 g of olafluor, 4 g of the polyoxyethylene hydrogenated eucalyptus oil prepared in Example 2 and 1 g of hydroxyapatite were added into a reaction kettle and mixed, and stirred with a magnetic stirrer at 25° C. and 800 rpm for 30 min to obtain product A;

[0046] 2: 1 g of green tea extract, 1 g of honeysuckle extract, 1 g of lemon extract and 1 g of ascorbic acid were dissolved in 150 g of pure water, and stirred with a magnetic stirrer at 35° C. and 800 rpm for 30 min to obtain product B;

[0047] 3: Product A and product B are mixed and stirred in a reactor, and then 1g of lactobacillus, 3g of menthol, 1g of sodium citrate, 4g of honey and 3g of licorice extract are added and mixed, and then 27.4g of pure water is added, and the stirrer speed is set to 1200rpm and mixed and stirred for 45min to obtain 200g of an effective anti-caries mouthwash prepared in Example 4.

[0048] Table 4, reagent parameters used in Example 4

[0049]

[0050]

[0051] Comparative Example 1

[0052] Example 1 of Chinese patent publication number CN111494409A was selected as comparative example 1.

[0053] Comparative Example 2

[0054] The specific implementation method of the embodiment of the Chinese patent with publication number CN110538134A is selected as comparative example 2.

[0055] Anti-moth effect test:

[0056] 100 volunteers aged 20-25 were recruited and divided into 5 groups, with 20 people in each group. The first four groups used the mouthwashes prepared by Example 3, Example 4, Comparative Example 1 and Comparative Example 2, respectively. The fifth group did not use any mouthwash product as the control group. The test period was 60 days. The volunteers ate the same food within 60 days and rinsed their mouths with 15 ml of mouthwash twice after each meal. After the test, an antibacterial activity experiment was performed, and the volunteers' tooth decay was detected at the same time.

[0057] Table 5, mothproofing effect test

[0058]

[0059]

[0060] By analyzing Table 5, it can be seen that the mouthwashes prepared in Examples 3 and 4 not only have excellent antibacterial effects, but also have obvious anti-caries effects. No tooth decay occurred in the 40 volunteers, and compared with the mouthwashes prepared in Comparative Examples 1 and 2, the volunteers did not experience any discomfort.

[0061] Gum swelling and pain effect test:

[0062] 100 volunteers aged 20-25 with swollen and painful gums were recruited and divided into 4 groups, with 25 people in each group. The mouthwashes prepared by Example 3, Example 4, Comparative Example 1 and Comparative Example 2 were used respectively. The test period was 60 days. The volunteers ate the same food within 60 days and rinsed their mouths with 15 ml of mouthwash twice after each meal. At the same time, the inhibitory effect of swollen and painful gums on the volunteers was tested.

[0063] The judging criteria are:

[0064] Cured: All symptoms of gingival swelling and pain disappeared

[0065] Effective: Symptoms of gingival swelling and pain were significantly alleviated

[0066] Ineffective: No significant improvement in gingival swelling and pain

[0067] Table 6, Gum swelling and pain effect test

[0068] Recovery rate Efficiency Inefficiency Example 3 24(96％) 1(4％) 0(0) Example 4 25(100％) 0(0) 0(0) Comparative Example 1 12(48％) 4(16％) 9(36％) Comparative Example 2 10(40％) 2(8％) 13(52％)

[0069] By analyzing Table 6, it can be seen that the mouthwash prepared in Example 3 and Example 4 has a very obvious therapeutic effect on patients with gingival swelling and pain compared with Comparative Example 1 and Comparative Example 2, wherein the effective rate and cure rate are higher than 95%.

[0070] Stability test:

[0071] The mouthwash prepared in Example 3, Example 4, Example 1 and Example 2 was tested for high and low temperature stability, and its appearance and smell were tested respectively. At the same time, the antiseptic test was performed. The bacterial suspension of the test sample was prepared according to 2.1.1.2.3 of the "Technical Specification for Disinfection" (2002), and the fungal suspension was prepared according to 2.1.1.9.3 of the "Technical Specification for Disinfection" (2002). In the antiseptic test, the test samples were 1 ml of the mouthwash of the vegetation in Example 3, Example 4, Comparative Example 1 and Comparative Example 2, and 9 ml of PBS was mixed and inoculated with a mixed colony of yeast and Aspergillus niger, and the inoculation amount was 1.2*10 6 cfu / L, the colony count is measured after fourteen days, and the pass standard of the antiseptic test is that the colony count is less than 10 cfu / L after fourteen days;

[0072] Table 7, 4℃ low stability test results

[0073]

[0074] Table 8, 48℃ high temperature stability test results

[0075]

[0076] Table 9, Anticorrosion Performance Test Results

[0077] 0h colony value Colony count at 14 days Result determination Example 3 <![CDATA[1.2*10 6 cfu / L]]> ＜10 pass Example 4 <![CDATA[1.2*10 6 cfu / L]]> ＜10 pass Comparative Example 1 <![CDATA[1.2*10 6 cfu / L]]> 28cfu / L Not passed Comparative Example 2 <![CDATA[1.2*10 6 cfu / L]]> 350cfu / L Not passed

[0078] By analyzing Table 7, Table 8 and Table 9, it can be seen that the mouthwashes prepared in Example 3 and Example 4 have excellent stability under low and high temperature environments compared with the mouthwashes prepared in Comparative Example 1 and Comparative Example 2, and also have excellent antiseptic properties.

[0079] The above shows and describes the basic principles and main features of the present invention and the advantages of the present invention. It should be understood by those skilled in the art that the present invention is not limited to the above embodiments. The above embodiments and descriptions are only for explaining the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention may have various changes and improvements, which fall within the scope of the present invention to be protected. The scope of protection of the present invention is defined by the attached claims and their equivalents.

Claims

1. An effective anti-moth mouthwash, characterized in that: The invention is composed of the following percentage ingredients: 0.1-0.5% sodium fluoride, 0.1-0.5% sodium monofluorophosphate, 0.1-0.5% olafluan, 0.5-1% hydroxyapatite, 0.5-1% lactobacillus, 0.5-1.5% green tea extract, 0.5-1.5% honeysuckle extract, 1.5-2% menthol, 0.5-1% sodium citrate, 2-3% honey, 1.5-3% licorice extract, 0.5-1.5% lemon extract, 0.5-1.5% ascorbic acid, 2-3% polyoxyethylene hydrogenated eucalyptus oil and the balance is water; The preparation method of polyoxyethylene hydrogenated eucalyptus oil comprises the following steps: A1: Add eucalyptus oil to a blender, place the blender in a fume hood, turn on the fume hood ventilation, set the wind speed to 1.5-2m / s, turn on the blender, set the speed to 600-800rpm, and blend for 1.5-2h. Transfer the blended eucalyptus oil to a homogenizer, and homogenize for 30min to obtain homogenized eucalyptus oil. A2: Add the homogenized eucalyptus oil to an oscillator. Before adding, use a vacuum pump to extract the air in the oscillator to create a vacuum environment. Then connect the air inlet valve on the oscillator to a high-pressure nitrogen bottle, use nitrogen to protect the reaction system, fill with nitrogen, and make the air pressure in the oscillator 0.95-1.12atm. Then close the upper air inlet valve, and then change the valve on the oscillator to connect to the hydrogen generator. At the same time, open the upper air inlet valve and the oscillator pump. Open the lower air outlet valve every 10 minutes, use a vacuum pump to extract 10% nitrogen and hydrogen mixed gas. During the vacuum pump extraction process, adjust the upper air inlet valve and the lower air outlet valve to keep the pressure in the oscillator at 0.95-1.12atm. After 100 minutes, close the upper air inlet valve and the lower air outlet valve, and at the same time close the hydrogen generator and the vacuum pump. After oscillating for 2 hours, end the oscillation process to obtain hydrogenated eucalyptus oil. A3: Transfer the hydrogenated eucalyptus oil to a high-pressure reactor, adjust the speed of the magnetic stirrer to 1200-1500 rpm and the temperature to 45-50°C, add polyoxyethylene and a metal catalyst, connect the air inlet of the high-pressure reactor to a high-pressure nitrogen bottle, use nitrogen to protect the reaction system, fill the reactor with nitrogen to a pressure of 2.1-2.4 atm, and stir the reaction for 30-60 minutes; A4: The eucalyptus oil after the reaction is transferred to a distillation tower for heating and distillation. The temperature in the distillation tower is adjusted to 200-240°C and the distillation pressure is 0.3-0.6atm. The distillation is carried out for 5-6 hours, and the upper layer product of the distillation tower is collected and re-added to the agitator, and steps A1-A3 are repeated once or twice. The bottom layer product of the distillation tower is collected to obtain polyoxyethylene hydrogenated eucalyptus oil.

2. An effective anti-moth mouthwash according to claim 1, characterized in that: The metal catalyst described in step A3 is prepared by adding CaO and EDTA to pure ethanol in a ratio of 1:1 and stirring, then adding MnO and NiO in a mass ratio of n(MnO):n(CaO):n(EDTA):n(NiO)=1:1:1:1, ultrasonically dispersing until completely dissolved, and then calcining at 230-245°C in a muffle furnace for 1-1.5h, then transferring the calcined product to a drying oven, adjusting the drying oven temperature to 65°C, the wind speed to 1.5-2m / s, and drying for 30-45min.

3. An effective anti-moth mouthwash according to claim 1, characterized in that: The mass ratio of hydrogenated eucalyptus oil, polyoxyethylene and metal catalyst in step A3 is 6:3:

1.

4. An effective anti-moth mouthwash according to claim 1, characterized in that: The lactobacillus is Lactobacillus reuteri, and the specification is 90-110 cfu / g.

5. An effective anti-moth mouthwash according to claim 1, characterized in that: The lemon extract is water-soluble lemon powder with a specification of 10:1; the honeysuckle extract is water-soluble honeysuckle powder with a specification of 10:1; and the green tea extract is water-soluble green tea powder with a specification of 20:

1.

6. An effective anti-moth mouthwash according to claim 1, characterized in that: The licorice extract is a water-soluble licorice root extract with a specification of 20:

1.

7. An effective anti-moth mouthwash according to claim 1, characterized in that: The hydroxyapatite is white powdery basic calcium phosphate with a particle size of 5-20 um.

8. An effective anti-moth mouthwash according to claim 1, characterized in that: The sodium monofluorophosphate is water-soluble sodium monofluorophosphate with a specification of 10:

1.

9. The method for preparing an effective anti-moth mouthwash according to claim 1, characterized in that: The following steps are involved: B1: Sodium fluoride, sodium monofluorophosphate, olafluor, polyoxyethylene hydrogenated eucalyptus oil and hydroxyapatite were added into a reaction kettle and mixed, and stirred with a magnetic stirrer at 25° C. and 600-800 rpm for 30 min to obtain product A; B2: Add green tea extract, honeysuckle extract, lemon extract and ascorbic acid into pure water for dissolution, and stir with a magnetic stirrer at 35-40°C and 800-1000 rpm for 30 min to obtain product B; B3: Mix product A and product B in a reactor, then add lactobacillus, menthol, sodium citrate, honey and licorice extract, then add pure water, set the stirrer speed to 1200-1500 rpm and mix for 45-60 minutes to obtain an effective anti-caries mouthwash.

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