A kind of wormwood deodorizing foot soaking ball and preparation method thereof

Abstract

The present invention relates to the field of traditional Chinese medicine, and specifically discloses a wormwood deodorizing foot soaking ball and a preparation method thereof. The foot soaking ball comprises the following raw materials by weight: 40 to 60 parts of a traditional Chinese medicine extract and 5 to 12 parts of an antibacterial enhancer; wherein the traditional Chinese medicine used to prepare the traditional Chinese medicine extract comprises wormwood, prickly ash, dried ginger, notopterygium root, angelica root, saposhnikovia root, gentiana macrophylla, clematis root and mulberry branch. The present invention uses traditional Chinese medicines such as wormwood to extract active substances, kneads them with a stabilizer with good dispersibility in water, forms a highly flexible serosal film on the surface of the extract powder, improves the storage stability of the active ingredients, and is compounded with an antibacterial enhancer adapted to the system, so that the foot soaking ball has a killing effect on bacteria and fungi, and can effectively alleviate the problems of odor, itching and the like caused by tinea pedis.

Description

Technical Field

[0001] The invention belongs to the field of traditional Chinese medicine, and particularly relates to a wormwood deodorizing foot soaking ball and a preparation method thereof. Background Art

[0002] Foot bath is a common leisure and health care activity. People usually add functional auxiliary products such as foot bath powder, foot bath bag, foot bath ball, etc. to achieve better foot bath effect. In the prior art, the products used for bathing are mainly bath salts. For example, patent CN110101589A discloses an effervescent bath salt ball, which contains magnesium chloride, sodium bicarbonate, citric acid, foaming agent and surfactant. The bath salt ball dissolves quickly and has the function of sterilization and disinfection. However, the water containing the above components is easy to cause skin dehydration after long-term contact with the human body, resulting in itching, dandruff and other phenomena.

[0003] In response to the above problems, many businesses have developed a series of bathing products containing Chinese medicine ingredients based on the theory of traditional Chinese medicine. For example, patent CN112168901A discloses a foot soaking ball containing saffron extract base liquid, which uses Chinese medicine saffron to enhance the excretion of cold air and waste in the body, effectively prevents and treats symptoms such as uterine cold and body cold, and also has a certain therapeutic effect on gout and onychomycosis. However, after being placed for a long time, whether the activity of the saffron extract base liquid can be effectively retained in the foot soaking ball remains to be investigated. In addition, considering the lack of antibacterial bathing products on the market, the present invention provides a foot soaking ball with low skin irritation, high Chinese medicine active ingredients, and antibacterial and fungal effects. Summary of the invention

[0004] In order to overcome the shortcomings of the above-mentioned prior art, the present invention uses low-irritation Chinese medicinal materials such as wormwood to extract active substances, improves the storage stability of the active ingredients through a special stabilizer, and compounded with an antibacterial enhancer to provide a foot soaking ball that has a killing effect on bacteria and fungi, effectively alleviating the problems of odor, itching and so on caused by tinea pedis.

[0005] In order to achieve the above object, the technical solution adopted by the present invention is:

[0006] On the one hand, the present invention provides a mugwort deodorizing foot soaking ball, which comprises the following raw materials by weight: 40 to 60 parts of a Chinese medicine extract and 5 to 12 parts of an antibacterial enhancer; wherein the Chinese medicine used to prepare the Chinese medicine extract comprises mugwort, zanthoxylum bungeanum, dried ginger, notopterygium wilfordii, angelica pubescens, siler, gentiana macrophylla, clematis radix and mulberry branches.

[0007] In some embodiments, based on 100wt%, the traditional Chinese medicine comprises 50-60wt% wormwood, 4-8wt% prickly ash, 8-14wt% dried ginger, 5-10wt% notopterygium root, 4-10wt% angelica dahurica, 3-6wt% siler, 3-6wt% gentiana macrophylla, 5-10wt% clematis root and 5-10wt% mulberry branch.

[0008] Tinea pedis is a common fungal infection of the skin. It is highly contagious and has a high recurrence rate. Symptoms such as odor and itching often occur at the infected site. The main pathogen is Trichophyton rubrum. The foot soaking ball provided by the present invention adopts Chinese medicinal materials mainly composed of wormwood, and is compounded with an antibacterial enhancer, which has a killing effect on bacteria and fungi, and effectively alleviates the odor and itching problems caused by tinea pedis.

[0009] In some embodiments, the preparation steps of the Chinese medicine extract are as follows:

[0010] The Chinese medicine is crushed and sieved to obtain Chinese medicine powder, 50-95v% ethanol is added, and the mixture is heated under reflux at 70-90°C for 1-4h, filtered, concentrated, and dried to obtain extract powder, and a stabilizer is added and kneaded to obtain the Chinese medicine extract.

[0011] The present invention adds the Chinese medicine extract into the foot soaking ball. Compared with directly adding the Chinese medicine powder, this method is convenient to use and does not need to wait for the active ingredient to dissolve during use. In addition, the present invention improves the storage stability of the active ingredient by adding a stabilizer into the extract powder.

[0012] In some embodiments, the ratio of the traditional Chinese medicine powder to 50-95v% ethanol is 1 g: (15-25) mL.

[0013] The invention achieves a balance between extraction efficiency and extraction process cost by specifically selecting the usage ratio of traditional Chinese medicine powder and extraction solvent.

[0014] In some embodiments, the mass ratio of the extract powder to the stabilizer is 1:(0.01-0.06).

[0015] The invention controls the mass ratio between the extract powder and the stabilizer so that the obtained traditional Chinese medicine extract has good water solubility, storage stability and low cost.

[0016] In some embodiments, the preparation steps of the stabilizer are as follows:

[0017] S1, dissolving quaternary ammonium cationic starch in a buffer solution of pH=4.5 to obtain starch milk with a concentration of 35-45wt%;

[0018] S2, dissolving sodium periodate in a buffer solution of pH=4.5 to obtain a reaction solution, adding the reaction solution to the starch milk of step S1 at -5 to 5°C, and stirring until the periodate reaction is complete, thereby obtaining the stabilizer.

[0019] The present invention uses quaternary ammonium cationic starch milk as a raw material, and the molecules of the starch contain a large number of reactive hydroxyl groups. Sodium periodate is used to specifically oxidize the hydroxyl groups and introduce aldehyde groups to obtain a stabilizer. The preparation process of the stabilizer is simple and almost no post-processing steps are required. The iodine ions that have not been removed in the finished product also have a killing effect on fungi and bacteria.

[0020] Among them, the quaternary ammonium cationic starch emulsion itself has good viscosity. After kneading, it can form a serum film on the surface of the extract powder, reduce contact with oxygen, improve antioxidant properties and shape stability of the foot bath ball, and facilitate transportation. However, its dispersibility in water is poor, so that the foot bath ball cannot dissolve quickly; the introduced aldehyde group can enhance the dispersibility in water, while also weakening the hydrogen bond association between starch hydroxyl groups, causing the orderly arrangement of starch molecular chains to be disturbed, thereby improving the flexibility of the serum film. Since the foot bath ball needs to be extruded and kneaded together with the antibacterial enhancer during preparation, the improvement in flexibility helps to avoid direct contact between the Chinese medicine extract and the antibacterial enhancer, further ensuring the stability of the active substance.

[0021] In some embodiments, the mass ratio of the quaternary ammonium cationic starch in step S1 to the sodium periodate in step S2 is 1:(0.018-0.036).

[0022] The invention controls the mass ratio of quaternary ammonium cationic starch to sodium periodate and thus controls the degree of oxidation of the hydroxyl group of the cationic starch, thereby ensuring the water-soluble effect of the traditional Chinese medicine extract.

[0023] In some embodiments, the pH of the buffer solution is 4-6.

[0024] In some embodiments, the antimicrobial enhancing agent comprises benzoic acid and salicylic acid.

[0025] Preferably, the mass ratio of benzoic acid to salicylic acid is 1:(2-4).

[0026] The present invention enhances the antibacterial effect by adding benzoic acid and salicylic acid, wherein benzoic acid can interfere with the metabolic process in bacteria by inhibiting the activities of respiratory enzymes, dehydrogenases and oxidoreductases of microbial cells, thereby exerting an antibacterial and bactericidal effect. The stabilizer in the above-mentioned traditional Chinese medicine extract can not only prevent benzoic acid and salicylic acid from causing ineffectiveness of active extract substances, but the acidic environment of the stabilizer can make benzoic acid show stronger bactericidal ability than the alkaline environment; salicylic acid exerts a bactericidal effect by penetrating and destroying cell membranes, interfering with bacterial enzyme activity and changing the physiological function of bacteria.

[0027] Another aspect of the present invention provides a method for preparing a mugwort deodorizing foot soaking ball, comprising the following preparation steps: extruding and kneading a traditional Chinese medicine extract and an antibacterial enhancer to obtain the mugwort deodorizing foot soaking ball.

[0028] Compared with the prior art, the present invention has the following beneficial effects:

[0029] 1. The present invention adopts Chinese medicinal materials mainly composed of mugwort and is compounded with an antibacterial enhancer to provide a foot soaking ball that has a killing effect on bacteria and fungi, effectively alleviating the problems of odor, itching and the like caused by tinea pedis.

[0030] 2. The present invention extracts the active ingredients of traditional Chinese medicine and adds them into the foot soaking ball. There is no need to wait for the active ingredients to dissolve when using the foot soaking ball. In addition, the storage stability of the active ingredients is improved by adding a stabilizer into the extract powder.

[0031] 3. The stabilizer provided by the present invention has good dispersibility in water, can make the foot soaking ball dissolve quickly, can form a highly flexible serous film on the surface of the extract powder after kneading, reduce contact with oxygen, improve antioxidant properties and shape stability of the foot soaking ball, and facilitate transportation. When extruded and kneaded together with the antibacterial enhancer, direct contact between the traditional Chinese medicine extract and the antibacterial enhancer can be avoided, reducing interference with active substances; and the preparation process of the stabilizer is simple, and almost no post-processing steps are required. The iodine ions that have not been removed in the finished product also have a killing effect on fungi and bacteria.

[0032] 4. The present invention selects benzoic acid and salicylic acid as antibacterial enhancers adapted to the system, among which benzoic acid exhibits stronger bactericidal ability in the slightly acidic environment provided by the stabilizer. DETAILED DESCRIPTION

[0033] The present invention will be described below in conjunction with specific embodiments. It should be noted that the following embodiments are examples of the present invention and are only used to illustrate the present invention, but not to limit the present invention. Other combinations and various modifications within the concept of the present invention may be performed without departing from the spirit or scope of the present invention.

[0034] In order to facilitate those skilled in the art to implement the present invention, some raw materials and manufacturers of the embodiments are described as follows:

[0035] Quaternary ammonium cationic starch was purchased from Dezhou Runde Starch Co., Ltd.

[0036] Preparation Example 1

[0037] The preparation steps of stabilizer A are as follows:

[0038] S1, dissolving quaternary ammonium cationic starch in a phosphate buffer solution with a pH of 4.5 to obtain a starch milk with a concentration of 40 wt%;

[0039] S2. Dissolve sodium periodate in a phosphate buffer solution with a pH of 4.5 to obtain a reaction solution with a concentration of 5 wt%, and add it to the starch milk in step S1 at 0°C. The mass ratio of the quaternary ammonium cationic starch in step S1 to the sodium periodate in step S2 is 1:0.027. Stir until the periodate reaction is completed to obtain stabilizer A.

[0040] Preparation Example 2

[0041] The preparation steps of stabilizer B are as follows:

[0042] The difference between this preparation example and preparation example 1 is that the mass ratio of the quaternary ammonium cationic starch in step S1 to the sodium periodate in step S2 is 1:0.015.

[0043] Preparation Example 3

[0044] The preparation steps of stabilizer C are as follows:

[0045] The difference between this preparation example and preparation example 1 is that the mass ratio of the quaternary ammonium cationic starch in step S1 to the sodium periodate in step S2 is 1:0.039.

[0046] Preparation Example 4

[0047] The preparation steps of Chinese herbal medicine extract A are as follows:

[0048] Based on 100wt%, the traditional Chinese medicine comprises 55wt% wormwood, 6wt% zanthoxylum bungeanum, 10wt% dried ginger, 6wt% notopterygium wilfordii, 5wt% angelica pubescens, 3wt% saposhnikovia divaricata, 3wt% gentiana macrophylla, 5wt% clematis and 7wt% mulberry branch. The traditional Chinese medicine is crushed and passed through an 80-mesh sieve to obtain traditional Chinese medicine powder. 70v% ethanol is added at a ratio of 1g:20mL, and the mixture is heated under reflux at 80°C for 3h, filtered, and concentrated to one tenth of the original volume. The mixture is dried at 50°C to obtain extract powder. Stabilizer A is added at a mass ratio of 1:0.03 between the extract powder and stabilizer A, and the mixture is kneaded to obtain traditional Chinese medicine extract A.

[0049] Preparation Example 5

[0050] The preparation steps of Chinese herbal medicine extract B are as follows:

[0051] The difference between this preparation example and preparation example 4 is that stabilizer A is replaced by stabilizer B in an equal amount.

[0052] Preparation Example 6

[0053] The preparation steps of Chinese herbal medicine extract C are as follows:

[0054] The difference between this preparation example and preparation example 4 is that stabilizer A is replaced by stabilizer C in an equal amount.

[0055] Preparation Example 7

[0056] The preparation steps of Chinese herbal medicine extract D are as follows:

[0057] The difference between this preparation example and preparation example 4 is that, based on 100wt%, the traditional Chinese medicine comprises 45wt% wormwood, 10wt% zanthoxylum bungeanum, 15wt% dried ginger, 4wt% angelica dahurica, 4wt% angelica pubescens, 3wt% siler, 3wt% gentiana macrophylla, 4wt% clematis and 12wt% mulberry branch.

[0058] Preparation Example 8

[0059] The preparation steps of Chinese herbal medicine extract E are as follows:

[0060] The difference between this preparation example and preparation example 4 is that, based on 100wt%, the traditional Chinese medicine contains 55wt% wormwood, 3wt% prickly ash, 5wt% dried ginger, 8wt% notopterygium root, 6wt% angelica root, 7wt% siler, 7wt% gentiana macrophylla, 6wt% clematis root and 3wt% mulberry branch.

[0061] Preparation Example 9

[0062] The preparation steps of Chinese herbal medicine extract F are as follows:

[0063] Based on 100wt%, the traditional Chinese medicine comprises 55wt% wormwood, 6wt% zanthoxylum bungeanum, 10wt% dried ginger, 6wt% notopterygium wilfordii, 5wt% angelica pubescens, 3wt% saposhnikovia divaricata, 3wt% gentiana macrophylla, 5wt% clematis and 7wt% mulberry branch. The traditional Chinese medicine is crushed and passed through an 80-mesh sieve to obtain traditional Chinese medicine powder. 70v% ethanol is added at a ratio of 1g:20mL, the mixture is heated under reflux at 80°C for 3h, filtered, concentrated to one tenth of the original volume, and dried at 50°C to obtain an extract powder, which is the traditional Chinese medicine extract F.

[0064] Example 1

[0065] A mugwort deodorizing foot soaking ball comprises the following raw materials, measured by weight: 50 parts of a traditional Chinese medicine extract A, 2 parts of benzoic acid and 6 parts of salicylic acid.

[0066] The preparation method of the wormwood deodorizing foot soaking ball in this embodiment comprises the following steps: the Chinese medicine extract A, benzoic acid and salicylic acid are squeezed and kneaded to obtain the wormwood deodorizing foot soaking ball.

[0067] Example 2

[0068] A mugwort deodorizing foot soaking ball comprises the following raw materials, measured by weight: 40 parts of a traditional Chinese medicine extract A, 1.6 parts of benzoic acid and 3.4 parts of salicylic acid.

[0069] The preparation method of the mugwort deodorizing foot soaking ball in this embodiment is the same as that in Example 1.

[0070] Example 3

[0071] A mugwort deodorizing foot soaking ball comprises the following raw materials, measured by weight: 60 parts of a traditional Chinese medicine extract A, 2.4 parts of benzoic acid and 9.6 parts of salicylic acid.

[0072] The preparation method of the mugwort deodorizing foot soaking ball in this embodiment is the same as that in Example 1.

[0073] Example 4

[0074] This embodiment provides a mugwort deodorizing foot bath ball and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that the Chinese herbal extract A is replaced by an equal portion of Chinese herbal extract B.

[0075] Example 5

[0076] This embodiment provides a mugwort deodorizing foot bath ball and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that the Chinese herbal extract A is replaced by an equal portion of Chinese herbal extract C.

[0077] Example 6

[0078] This embodiment provides a mugwort deodorizing foot bath ball and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that the Chinese herbal extract A is replaced by an equal portion of Chinese herbal extract D.

[0079] Example 7

[0080] This embodiment provides a mugwort deodorizing foot bath ball and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that the Chinese herbal extract A is replaced by an equal portion of Chinese herbal extract E.

[0081] Example 8

[0082] This embodiment provides a mugwort deodorizing foot bath ball and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that salicylic acid is replaced by an equal portion of benzoic acid.

[0083] Example 9

[0084] This embodiment provides a mugwort deodorizing foot bath ball and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that benzoic acid is replaced by an equal portion of salicylic acid.

[0085] Example 10

[0086] This embodiment provides a mugwort deodorizing foot bath ball and a preparation method thereof. The specific implementation method is the same as that of Example 1, except that the Chinese herbal extract A is replaced by an equal portion of Chinese herbal extract F.

[0087] Performance Testing:

[0088] 1. In vitro anti-Trichophyton rubrum test

[0089] The experimental process complies with the standards of the Clinical and Laboratory Standards Institute (CLSI) of the United States, with the minimum inhibitory concentration (MIC) as the evaluation index. The specific steps are as follows:

[0090] 1) Strain activation and inoculation

[0091] The frozen Trichophyton rubrum glycerol tube was streaked and inoculated into a PDA plate, which was then cultured at 35°C and 80% humidity for 6 days.

[0092] 2) Preparation of inoculum

[0093] The plate was covered with 5 mL of 0.9 wt% NaCl solution, and the surface of the plate was gently scraped with a spreader to obtain a spore suspension. The suspension was diluted 100 times, and counted using a microscope and a red blood cell counter to obtain a stock solution with a spore concentration of about 505,000 spores / mL. 800 μL of the bacterial solution was added to 250 mL of test culture medium (RPMI1640 supplemented with 0.165 M MOPS, pH 7.0) to obtain an inoculum solution;

[0094] 3) Compound detection plate preparation

[0095] On the day of the experiment, the foot soaking ball provided in each example was diluted with DMSO to a 6.4 mg / mL working solution for use, and 2 μL of the working solution was transferred to a 96-U well plate with culture medium to obtain a compound detection plate;

[0096] 4) Compound detection plate inoculation

[0097] Add 198 μL of inoculum to the compound test plate to finally obtain the MIC test plate;

[0098] 5) MIC detection

[0099] The MIC test plate was placed at 35°C and 80% humidity, and the MIC value was read after 4 days of static culture (80% growth inhibition). The MIC reading standard was based on CLSIM38.

[0100] 2. Water dissolution rate test

[0101] The foot soaking ball provided in each embodiment was placed in 15L of water at a temperature of 40°C, with a diameter of 3±0.2cm. The ball was allowed to stand and the time for complete water dissolution (complete disappearance of the ball) was recorded, with 30s as the recording node.

[0102] 3. Active substance stability test

[0103] The foot soaking balls provided in each embodiment were placed in a dark and dry place at room temperature for 30 days, and then subjected to an in vitro anti-Trichophyton rubrum test, with the specific steps being the same as those in performance test 1.

[0104] The results are shown in Table 1.

[0105] Table 1 Performance test results

[0106]

[0107]

[0108] From the data in Table 1, it can be seen that the foot soaking balls of Examples 1 to 3 have a faster water dissolution rate and the best antibacterial effect on Trichophyton rubrum (MIC=64μg / mL). By comparing the antibacterial effect after 30 days, it can be seen that the Chinese medicine extracts in the foot soaking balls can maintain their activity for a longer time. Compared with Example 1, the stabilizer used in the Chinese medicine extracts of Examples 4 to 5 changed the mass ratio of quaternary ammonium cationic starch to sodium periodate during preparation, which changed the degree of hydroxyl oxidation of the starch, affecting the water dissolution rate of the foot soaking balls and the stability of the active substances.

[0109] Compared with Example 1, the Chinese medicinal materials used in the Chinese medicinal extracts of Examples 6-7 were adjusted in terms of dosage. Although they still had a good antibacterial effect (MIC=128μg / mL), they could not reach the best (MIC=64μg / mL). Compared with Example 1, the antibacterial enhancers of Examples 8-9 used a single salicylic acid or benzoic acid, which also had a certain antibacterial effect (MIC=256μg / mL). Compared with Example 1, the Chinese medicinal extract of Example 10 did not add a stabilizer during preparation, resulting in the gradual inactivation of the active substance, causing the antibacterial effect to decrease significantly after 30 days.

[0110] The embodiments described above do not impose any form of limitation on the present invention. Although the present invention has been disclosed as a preferred embodiment as above, it is not intended to limit the present invention. Any technician familiar with the profession can make some changes or modifications to equivalent embodiments of equivalent changes using the technical contents disclosed above without departing from the scope of the technical solution of the present invention. However, any simple modification, equivalent change and modification made to the above embodiments based on the technical essence of the present invention without departing from the content of the technical solution of the present invention still falls within the scope of the technical solution of the present invention.

Claims

1. A wormwood deodorizing foot soaking ball, characterized in that: The invention comprises the following raw materials by weight: 40 to 60 parts of Chinese herbal medicine extract and 5 to 12 parts of antibacterial enhancer; wherein the Chinese herbal medicine used to prepare the Chinese herbal medicine extract comprises mugwort, zanthoxylum bungeanum, dried ginger, notopterygium wilfordii, angelica pubescens, siler, gentiana macrophylla, clematis radix and mulberry branch.

2. The wormwood deodorizing foot soaking ball according to claim 1, characterized in that: Based on 100wt%, the traditional Chinese medicine comprises 50-60wt% of mugwort, 4-8wt% of prickly ash, 8-14wt% of dried ginger, 5-10wt% of notopterygium root, 4-10wt% of angelica root, 3-6wt% of siler, 3-6wt% of gentiana macrophylla, 5-10wt% of clematis root and 5-10wt% of mulberry branch.

3. The wormwood deodorizing foot soaking ball according to claim 1, characterized in that: The preparation steps of the Chinese medicine extract are as follows: The Chinese medicine is crushed and sieved to obtain Chinese medicine powder, 50-95v% ethanol is added, and the mixture is heated under reflux at 70-90°C for 1-4h, filtered, concentrated, and dried to obtain extract powder, and a stabilizer is added and kneaded to obtain the Chinese medicine extract.

4. The wormwood deodorizing foot soaking ball according to claim 3, characterized in that: The ratio of the Chinese medicine powder to 50-95v% ethanol is 1g: (15-25)mL.

5. The wormwood deodorizing foot soaking ball according to claim 3, characterized in that: The mass ratio of the extract powder to the stabilizer is 1:(0.01-0.06).

6. The wormwood deodorizing foot soaking ball according to claim 3, characterized in that: The preparation steps of the stabilizer are as follows: S1, dissolving quaternary ammonium cationic starch in a buffer solution to obtain a starch milk with a concentration of 35-45wt%; S2, dissolving sodium periodate in a buffer solution to obtain a reaction solution, adding the reaction solution to the starch milk in step S1 at -5 to 5°C, and stirring until the periodate reaction is complete, thereby obtaining the stabilizer.

7. The wormwood deodorizing foot soaking ball according to claim 6, characterized in that: The mass ratio of the quaternary ammonium cationic starch in step S1 to the sodium periodate in step S2 is 1:(0.018-0.036).

8. The wormwood deodorizing foot soaking ball according to claim 6, characterized in that: The pH of the buffer solution is 4-6.

9. The wormwood deodorizing foot soaking ball according to claim 1, characterized in that: The antimicrobial enhancers include benzoic acid and salicylic acid.

10. A method for preparing the wormwood deodorizing foot soaking ball according to any one of claims 1 to 9, characterized in that: The method comprises the following preparation steps: the Chinese medicine extract and the antibacterial enhancer are squeezed and kneaded to obtain the wormwood deodorizing foot soaking ball.

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