Renal artery balloon catheter for local drug perfusion

Abstract

The invention discloses a renal artery balloon catheter for local drug perfusion, and relates to the technical field of renal artery balloon catheters, the renal artery balloon catheter comprises an access unit, and the access unit comprises a connecting end, a perfusion joint arranged at one end of the connecting end, and a liquid injection joint arranged on the outer wall of the connecting end. The balloon has the advantages that a traditional integrally-injection-molded balloon is changed to be composed of multiple independent tubes, the balloon can be matched with the renal artery with the larger bending degree, the production cost of an enterprise can be reduced, the corrugated balloon formed through expansion and the concave-convex surface can disperse contact pressure, local compression on the intima is reduced, and the balloon has the good sealing effect. And the'grooves' of the waveform structure are in multi-point contact with the blood vessel wall, so that the friction force is increased, and the balloon is prevented from sliding under the impact of blood flow.

Description

Technical Field

[0001] The invention relates to the technical field of renal artery balloon catheters, in particular to a renal artery balloon catheter for local drug perfusion. Background Art

[0002] Renal artery drug infusion is a targeted treatment method that uses interventional technology to directly inject drugs into the renal artery. It aims to increase drug concentration in the lesion area while reducing systemic side effects. Specifically, a catheter enters the renal artery under image guidance to confirm the location of the lesion. The catheter then delivers the drug directly to the lesion area of ​​the kidney (such as tumors, narrowed blood vessels), making the local drug concentration significantly higher than the systemic circulation, thereby improving the efficacy.

[0003] Existing balloon catheters are integrally injection molded and have limited bending capabilities. In actual clinical practice, when a balloon catheter reaches a target area and the target blood vessel happens to be a tortuous blood vessel, the expanded balloon will cause local compression on the blood vessel, leading to damage to the vascular endothelium and dissection problems. Summary of the invention

[0004] In view of the above-mentioned prior art problems, the present invention is proposed.

[0005] The purpose of the present invention is to provide a renal artery balloon catheter for local drug perfusion, which aims to solve the problem that the existing balloon catheter has limited bending degree and causes local compression of the blood vessel when expanding in a tortuous blood vessel, resulting in damage and dissection of the blood vessel endothelium.

[0006] To solve the above technical problems, the present invention provides the following technical solutions: A renal artery balloon catheter for local drug perfusion, comprising an access unit, including a connecting end, a perfusion connector arranged at one end of the connecting end, and a liquid injection connector arranged on the outer wall of the connecting end;

[0007] The insertion unit includes a balloon, a ball head disposed at one end of the balloon, a connecting groove provided on the outer wall of the balloon, a connecting tube and an annular airbag provided in the connecting groove, a through hole provided on the connecting tube, and an anti-blocking component provided outside the through hole;

[0008] The connecting unit comprises an inner tube arranged between the perfusion joint and the ball head, and an outer tube arranged between the connecting end head and the balloon.

[0009] As a preferred embodiment of the renal artery balloon catheter for local drug perfusion of the present invention, the perfusion connector comprises a perfusion tube disposed at one end of the connection end, a sealing cap disposed at one end of the perfusion tube, and a perfusion end disposed in the inner cavity of the sealing cap;

[0010] The perfusion end is connected to one end of the inner tube.

[0011] As a preferred embodiment of the renal artery balloon catheter for local drug perfusion of the present invention, a sealing gasket is provided between the perfusion tube and the sealing cover.

[0012] As a preferred embodiment of the renal artery balloon catheter for local drug perfusion of the present invention, the injection connector includes an injection tube arranged on the outer wall of the connecting end, and a medical valve arranged at one end of the injection tube.

[0013] As a preferred embodiment of the renal artery balloon catheter for local drug perfusion of the present invention, a connecting hole is provided between the ball head and the balloon.

[0014] As a preferred embodiment of the renal artery balloon catheter for local drug perfusion of the present invention, the anti-blockage component includes a sealing cover arranged on the outer wall of the connecting tube, a through groove opened on the outside of the sealing cover, and a shielding cover arranged on the outside of the sealing cover.

[0015] As a preferred embodiment of the renal artery balloon catheter for local drug perfusion of the present invention, the number of the annular balloons is multiple groups.

[0016] As a preferred embodiment of the renal artery balloon catheter for local drug perfusion of the present invention, the expansion diameter of the annular balloon is 2 mm-12 mm.

[0017] As a preferred embodiment of the renal artery balloon catheter for local drug perfusion of the present invention, the annular balloon can be completely contracted into the inner cavity of the balloon when in a contracted and folded state.

[0018] As a preferred solution of the renal artery balloon catheter for local drug perfusion of the present invention, the connecting tube is a flexible hose.

[0019] The beneficial effects of the renal artery balloon catheter for local drug perfusion of the present invention are: by changing the traditional one-piece injection-molded balloon into a multi-section "individual tube" structure, it can not only adapt to renal arteries with greater curvature, but also reduce the production cost of the enterprise. The corrugated airbag formed by expansion has a concave and convex surface that can disperse the contact pressure and reduce local compression on the vascular endothelium. The "grooves" of the corrugated structure form multiple points of contact with the blood vessel wall, increasing friction and preventing the balloon from sliding under the impact of blood flow. BRIEF DESCRIPTION OF THE DRAWINGS

[0020] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for use in the description of the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other drawings can be obtained based on these drawings without creative work.

[0021] Figure 1 It is a structural schematic diagram of the present invention.

[0022] Figure 2 It is a schematic diagram of the structure of the balloon of the present invention in a contracted and folded state.

[0023] Figure 3 It is a structural diagram of the access unit.

[0024] Figure 4 It is a cross-sectional view of the structure where the unit is inserted.

[0025] Figure 5 This is an enlarged cross-sectional view of the local structure at the insertion unit.

[0026] Figure 6 This is a schematic diagram of the structure of the balloon in Example 2 when it is in a contracted and folded state.

[0027] Figure 7 This is a schematic diagram of the structure of the balloon in the expanded state in Example 2.

[0028] In the figure: 1. access unit; 11. connecting end; 12. perfusion joint; 121. perfusion tube; 122. sealing cover; 123. perfusion end; 1221. sealing pad; 13. injection joint; 131. injection tube; 132. medical valve; 2. insertion unit; 21. balloon; 22. ball head; 23. connecting groove; 24. connecting tube; 25. annular airbag; 26. through hole; 27. anti-blocking component; 221. connecting hole; 271. sealing cover; 272. through groove; 273. shielding cover; 3. connecting unit; 31. inner tube; 32. outer tube. DETAILED DESCRIPTION

[0029] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific implementation methods of the present invention are described in detail below in conjunction with the accompanying drawings.

[0030] In the following description, many specific details are set forth to facilitate a full understanding of the present invention, but the present invention may also be implemented in other ways different from those described herein, and those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0031] Secondly, the term "one embodiment" or "embodiment" as used herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The term "in one embodiment" that appears in different places in this specification does not necessarily refer to the same embodiment, nor is it a separate or selective embodiment that is mutually exclusive with other embodiments.

[0032] Reference Figures 1 to 5 , which is the first embodiment of the present invention, and which provides a renal artery balloon catheter for local drug perfusion, comprising an access unit 1, comprising a connecting end 11, a perfusion connector 12 disposed at one end of the connecting end 11, and a liquid injection connector 13 disposed on the outer wall of the connecting end 11;

[0033] The insertion unit 2 includes a balloon 21, a ball head 22 disposed at one end of the balloon 21, a connection groove 23 provided on the outer wall of the balloon 21, a connection tube 24 and an annular air bag 25 provided in the connection groove 23, a through hole 26 provided on the connection tube 24, and an anti-blocking component 27 provided outside the through hole 26;

[0034] The connection unit 3 includes an inner tube 31 disposed between the perfusion joint 12 and the ball head 22 , and an outer tube 32 disposed between the connection end 11 and the balloon 21 .

[0035] It should be noted that the access unit 1 is composed of a connection terminal 11, a perfusion joint 12, and a liquid injection joint 13. The inner tube 31 enters the inner cavity of the connection terminal 11 from one end of the connection terminal 11 and is connected to the perfusion joint 12. The inner cavity of the liquid injection joint 13 is connected to the inner cavity of the connection terminal 11. One end of the connection terminal 11 is sealed and connected to one end of the outer appearance 32. The perfusion joint 12 seals the top of the connection terminal 11.

[0036] The two ends of the balloon 21 are sealed and connected to the outer tube 32 and the ball head 22 respectively. A plurality of connecting grooves 23 are provided on the balloon 21. The connecting grooves 23 divide the balloon 21 into a plurality of "separate tubes". A connecting tube 24 and an annular airbag 25 are sealed and connected between the inner walls of two adjacent "separate tubes". A "sealed cavity" is formed between the annular airbag 25, the connecting grooves 23 and the connecting tube 24. A through hole 26 is provided on the connecting tube 24 to connect the "sealed cavity" with the inner cavity of the balloon 21.

[0037] The number of the annular airbags 25 is multiple groups, and the expansion diameter of the annular airbags 25 is 2mm-12mm;

[0038] It should be noted that when the multiple groups of annular airbags 25 are expanded, they form a corrugated balloon with the balloon 21, forming a multi-layer barrier on the inner wall of the renal artery, and in order to meet the radius of the renal artery, the expansion diameter of the annular airbag 25 is 2mm-12mm.

[0039] The connecting pipe 24 is a flexible hose.

[0040] It should be noted that the connecting tube 24 is a flexible hose, and a multi-section "single tube" can adapt to the renal artery with a large degree of curvature. The multi-section connection structure can avoid one of the "single tubes" or the connecting parts from being damaged during the production process, and the accessories can be replaced, avoiding the problem of partial defects during the one-piece injection molding of the traditional balloon, which can only be discarded and increase the production cost of the enterprise.

[0041] When in use, the injection connector 13 is connected to the contrast agent injection device, the perfusion connector 12 is connected to the drug injection device, and then the corresponding pipelines are vented, and the balloon 21 is inserted into the renal artery and inserted into the target area, and then the contrast agent is introduced, and the specific position of the balloon 21 is seen through X-ray to ensure that it is accurately placed in the target area;

[0042] Then, the contrast agent is continuously injected, and the contrast agent enters the "sealed cavity" through the through hole 26 and squeezes the annular airbag 25 toward the outer wall. Multiple annular airbags 25 expand outward to form a "wave-shaped airbag", forming a multi-layer barrier to fix the renal artery, and then the drug is perfused into the target area to achieve local precise perfusion.

[0043] In summary, by changing the traditional one-piece injection-molded balloon into a multi-section "separate tube" structure, it can not only adapt to renal arteries with greater curvature, but also reduce the company's production costs. The corrugated airbag formed by expansion and the concave and convex surface can disperse the contact pressure and reduce local compression on the vascular endothelium. The "grooves" of the corrugated structure form multiple points of contact with the blood vessel wall, increasing friction and preventing the balloon from sliding under the impact of blood flow.

[0044] like Figures 1 to 3 As shown, as an optional embodiment: the perfusion joint 12 includes a perfusion tube 121 disposed at one end of the connection terminal 11, a sealing cover 122 disposed at one end of the perfusion tube 121, and a perfusion terminal 123 disposed in the inner cavity of the sealing cover 122;

[0045] The injection end 123 is connected to one end of the inner tube 31;

[0046] A sealing gasket 1221 is provided between the perfusion tube 121 and the sealing cover 122;

[0047] The injection connector 13 includes an injection tube 131 disposed on the outer wall of the connecting end 11 , and a medical valve 132 disposed at one end of the injection tube 131 .

[0048] It should be noted that the perfusion tube 121 is sealed and arranged at one end of the connection terminal 11, the top of the perfusion tube 121 is threadedly connected with a sealing cap 122, the inner cavity of the sealing cap 122 is sealed and connected with a perfusion terminal 123, and one end of the perfusion terminal 123 is sealed and connected with one end of the inner tube 31;

[0049] The injection tube 131 is sealedly connected to the outer wall of the connecting end 11 , and a medical valve 132 is threadedly connected to one end of the injection tube 131 .

[0050] like Figures 1 to 5 As shown, as an optional embodiment: a connecting hole 221 is provided between the ball head 22 and the balloon 21 .

[0051] It should be noted that a connecting hole 221 is provided between the ball head 22 and the balloon 21 to connect the inner cavities of the two. The ball head 22 can prevent the balloon 21 from scratching the vascular endothelium during the insertion of the balloon 21 into the renal artery. The contrast fluid enters the inner cavity of the ball head 22. Since the drug flows out from the ball head 22, the X-ray scanning positioning will be more accurate, and the air inside the hollow ball head 22 may interfere with the diagnosis process.

[0052] like Figure 5 As shown, as an optional embodiment: the anti-blocking component 27 includes a sealing cover 271 arranged on the outer wall of the connecting pipe 24, a through groove 272 opened on the outside of the sealing cover 271, and a shielding cover 273 arranged on the outside of the sealing cover 271.

[0053] It should be noted that the outer wall of the connecting tube 24 is sealed and connected to a sealing cover 271, the through hole 26 is located within the wrapping range of the sealing cover 271, a through groove 272 is opened on the side of the sealing cover 271 to form a passage, and a shielding cover 273 is wrapped around the outer side of the through groove 272. When the annular airbag 25 shrinks, the shielding cover 273 will intercept and shield the annular airbag to prevent the shrunken and folded annular airbag 25 from blocking the passage, resulting in incomplete shrinkage and scratching of the tracheal endothelium.

[0054] Example 2

[0055] like Figures 1 to 7 As shown, it is a second embodiment of the present invention based on the first embodiment. The annular airbag 25 will be completely contracted into the inner cavity of the balloon 21 when in the contracted and folded state.

[0056] It should be noted that when the annular airbag 25 is deflated and completely deflated into the balloon 21, a cross section is formed between the "individual tubes".

[0057] During use, when the target area is coated with medicine through the balloon catheter, the coated medicine is loaded in the cross-section of the contracted balloon 21. During the insertion into the blood vessel, the cross-section will reduce the impact force of the blood and reduce the loss of medicine. Then, when the balloon 21 reaches the target area, the contrast agent is injected and the annular airbag 25 expands to fit the blood vessel.

[0058] In summary, when the balloon 21 is in the contracted and shielded state, the cross section formed reduces the loss of drugs, and when it is expanded to form a "wave-shaped balloon", the wave-shaped structure will expand the drug contact area and promote the penetration of anti-proliferative drugs such as paclitaxel into the blood vessel wall.

[0059] It is important to note that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the claims of the present invention.

Claims

1. A renal artery balloon catheter for local drug perfusion, characterized in that: include, An access unit (1) comprises a connection end (11), a perfusion joint (12) arranged at one end of the connection end (11), and a liquid injection joint (13) arranged on the outer wall of the connection end (11); The insertion unit (2) comprises a balloon (21), a ball head (22) arranged at one end of the balloon (21), a connecting groove (23) provided on the outer wall of the balloon (21), a connecting tube (24) and an annular air bag (25) provided in the connecting groove (23), a through hole (26) provided on the connecting tube (24), and an anti-blocking component (27) provided outside the through hole (26); The connection unit (3) comprises an inner tube (31) arranged between the perfusion joint (12) and the ball head (22), and an outer tube (32) arranged between the connection end head (11) and the balloon (21).

2. The renal artery balloon catheter for local drug infusion according to claim 1, characterized in that: The perfusion joint (12) comprises a perfusion tube (121) arranged at one end of the connection terminal (11), a sealing cover (122) arranged at one end of the perfusion tube (121), and a perfusion terminal (123) arranged in the inner cavity of the sealing cover (122); The injection end head (123) is connected to one end of the inner tube (31).

3. The renal artery balloon catheter for local drug infusion as claimed in claim 2, characterized in that: A sealing gasket (1221) is provided between the perfusion tube (121) and the sealing cover (122).

4. The renal artery balloon catheter for local drug infusion according to claim 1, characterized in that: The injection connector (13) comprises an injection tube (131) arranged on the outer wall of the connection end (11), and a medical valve (132) arranged at one end of the injection tube (131).

5. The renal artery balloon catheter for local drug infusion according to claim 1, characterized in that: A connecting hole (221) is provided between the ball head (22) and the balloon (21).

6. The renal artery balloon catheter for local drug infusion according to claim 1, characterized in that: The anti-blocking component (27) comprises a sealing cover (271) arranged on the outer wall of the connecting pipe (24), a through groove (272) opened on the outside of the sealing cover (271), and a shielding cover (273) arranged on the outside of the sealing cover (271).

7. The renal artery balloon catheter for local drug infusion according to claim 1, characterized in that: The annular airbags (25) are provided in multiple groups.

8. The renal artery balloon catheter for local drug infusion according to claim 1, characterized in that: The expansion diameter of the annular airbag (25) is 2 mm to 12 mm.

9. The renal artery balloon catheter for local drug infusion according to claim 1, characterized in that: The annular airbag (25) will completely shrink into the inner cavity of the balloon (21) when in a contracted and folded state.

10. The renal artery balloon catheter for local drug infusion according to claim 1, characterized in that: The connecting pipe (24) is a flexible hose.

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