Dose distribution detection device for particle radiotherapy

Abstract

The invention relates to the technical field of particle radiotherapy, and provides a dose distribution detection device for particle radiotherapy, which comprises a multi-channel current and voltage conversion circuit, an analog-to-digital conversion module, a logic control module, a dose distribution detector and an upper computer, each channel of the dose distribution detector is connected with one channel of the multi-channel current and voltage conversion circuit, each channel of the multi-channel current and voltage conversion circuit is a double-integral architecture circuit comprising two integral modules, and the multi-channel current and voltage conversion circuit is connected with the analog-to-digital conversion module and the logic control module. The analog-to-digital conversion module is connected with the logic control module which is connected with the upper computer. According to the dose distribution detection device, due to the fact that a double-integral structure of the two integral modules is adopted, and the two integral modules are controlled by the logic control module to alternately execute the actions of integral, voltage output and discharging, the continuous current pulse signals of each channel are segmented without dead time, and therefore the counting rate of the dose distribution detection device is increased.

Description

Technical Field

[0001] This invention relates to the field of particle radiotherapy technology, and in particular to a dose distribution detection device for particle radiotherapy. Background Technology

[0002] With the development of particle radiotherapy technology, particle radiotherapy is gradually moving from conventional radiotherapy to ultra-high dose rate radiotherapy, also known as flash radiotherapy. Flash radiotherapy delivers ultra-high dose rate (≥40 Gy / s) rays, which can kill tumor cells while greatly reducing damage to surrounding normal cells. The dose rate required for flash radiotherapy is 2-3 orders of magnitude higher than that of existing radiotherapy systems. However, the highest count rate of current dose distribution detection devices is only 100 kJ / s (i.e., 100,000 counts per second), which is insufficient to meet the ultra-high dose rate requirements of flash radiotherapy. Therefore, it is necessary to develop new high-count-rate dose distribution detection devices that can quickly and accurately measure the dose distribution in order to better assess the radiation dose received by local tissues. Summary of the Invention

[0003] This invention provides a dose distribution detection device for particle radiotherapy, which solves the problem that existing dose distribution detection devices cannot meet the requirements of ultra-high dose rates during flash radiotherapy.

[0004] The present invention provides a dose distribution detection device for particle radiotherapy, comprising: a multi-channel current-to-voltage conversion circuit, an analog-to-digital conversion module, a logic control module, a dose distribution detector, and a host computer.

[0005] Each channel of the multi-channel current-to-voltage conversion circuit is a dual-integration architecture circuit including two integration modules. Each channel of the dose distribution detector is connected to one channel of the multi-channel current-to-voltage conversion circuit. The multi-channel current-to-voltage conversion circuit is connected to the analog-to-digital conversion module and the logic control module. The analog-to-digital conversion module is connected to the logic control module, and the logic control module is connected to the host computer.

[0006] The host computer is used to send detection-related configuration parameters to the logic control module. The logic control module controls one of the integrator modules to integrate the current pulse signal output by the dose distribution detector according to the detection-related configuration parameters, and at the same time controls another integrator module to output voltage and discharge. The analog-to-digital conversion module collects the output voltage, converts it into a digital signal and sends it to the logic control module. The logic control module combines the digital signals into dose distribution data and sends the dose distribution data to the host computer for display and storage.

[0007] According to the present invention, a dose distribution detection device for particle radiotherapy is provided, wherein each channel of the multi-channel current-to-voltage conversion circuit includes: an integral selection switch, a first integral module, a second integral module, and a 2-to-1 selector. The dose distribution detector is connected to the input terminals of the first integral module and the second integral module respectively through the integral selection switch. The two input terminals of the 2-to-1 selector are respectively connected to the output terminals of the first integral module and the second integral module. The output terminal of the 2-to-1 selector is connected to the input terminal of the analog-to-digital conversion module.

[0008] The logic control module is connected to the integral selection switch, the first integral module, the second integral module, and the 2-to-1 selector. It is used to control the integral selection switch to select one of the integral modules to integrate the current pulse signal output by the dose distribution detector, and at the same time control the 2-to-1 selector to select the output voltage of the other integral module and discharge it. The output voltage of the other integral module is output to the analog-to-digital conversion module through the 2-to-1 selector.

[0009] According to the present invention, a dose distribution detection device for particle radiotherapy is provided, wherein the first integration module includes: a first operational amplifier, a first variable capacitor and a first discharge switch, the two ends of the first variable capacitor are respectively connected to the output terminal and the negative input terminal of the first operational amplifier, the negative input terminal of the first operational amplifier is connected to the first selection contact of the integration selection switch, the positive input terminal is grounded, the first discharge switch is connected in parallel with the first variable capacitor, and the control terminal of the first discharge switch is connected to the logic control module, and the output terminal of the first operational amplifier is connected to the first input terminal of the two-to-one selector.

[0010] According to the present invention, a dose distribution detection device for particle radiotherapy is provided, wherein the second integration module includes: a second operational amplifier, a second variable capacitor, and a second discharge switch. The two ends of the second variable capacitor are respectively connected to the output terminal and the negative input terminal of the second operational amplifier. The negative input terminal of the second operational amplifier is connected to the second selection contact of the integration selection switch, and the positive input terminal is grounded. The second discharge switch is connected in parallel with the second variable capacitor, and the control terminal of the second discharge switch is connected to the logic control module. The output terminal of the second operational amplifier is connected to the second input terminal of the two-to-one selector.

[0011] According to the dose distribution detection device for particle radiotherapy provided by the present invention, each channel of the multi-channel current-voltage conversion circuit further includes: an attenuation module, the input terminal of the attenuation module being connected to the output terminal of the two-to-one selector, and the output terminal of the attenuation module being connected to the input terminal of the analog-to-digital conversion module.

[0012] According to the present invention, a dose distribution detection device for particle radiotherapy is provided, wherein the attenuation module includes: a first resistor, a second resistor and a third resistor, wherein a first end of the first resistor is connected to the output end of the 2-to-1 selector, a second end of the first resistor is connected to the input end of the analog-to-digital conversion module, a first end of the second resistor is connected to the first end of the first resistor, a first end of the third resistor is connected to the second end of the first resistor, and the second ends of the second resistor and the third resistor are respectively grounded.

[0013] According to the dose distribution detection device for particle radiotherapy provided by the present invention, each channel of the multi-channel current-voltage conversion circuit further includes: a first voltage follower module, wherein the attenuation module is connected to the output terminal of the two-to-one selector through the first voltage follower module.

[0014] According to the dose distribution detection device for particle radiotherapy provided by the present invention, each channel of the multi-channel current-to-voltage conversion circuit further includes: a second voltage follower module, wherein the attenuation module is connected to the input terminal of the analog-to-digital conversion module through the second voltage follower module.

[0015] According to the dose distribution detection device for particle radiotherapy provided by the present invention, the N channels of the multi-channel current-voltage conversion circuit share a single N-channel analog-to-digital conversion module, wherein N is greater than or equal to 2.

[0016] According to the dose distribution detection device for particle radiotherapy provided by the present invention, all channels of the multi-channel current-voltage conversion circuit share a single logic control module.

[0017] The dose distribution detection device for particle radiotherapy provided by this invention includes: a multi-channel current-to-voltage conversion circuit, an analog-to-digital conversion module, a logic control module, a dose distribution detector, and a host computer. Each channel of the multi-channel current-to-voltage conversion circuit is a dual-integration architecture circuit including two integration modules. The logic control module controls the two integration modules to alternately perform integration and output voltage discharge, achieving dead-time-free segmentation processing of the continuous current pulse signal of each channel in the dose distribution detector. Furthermore, the segmented voltage signal is rapidly digitized by the analog-to-digital conversion module to obtain a digital signal, thereby improving the count rate of dose distribution detection and meeting the requirements of ultra-high dose rates during flash radiotherapy. Attached Figure Description

[0018] To more clearly illustrate the technical solutions in this invention or the prior art, the drawings used in the description of the embodiments or the prior art will be briefly introduced below. Obviously, the drawings described below are some embodiments of this invention. For those skilled in the art, other drawings can be obtained from these drawings without creative effort.

[0019] Figure 1 This is a schematic diagram of the dose distribution detection device for particle radiotherapy provided by the present invention.

[0020] Figure 2 This is a schematic diagram of the circuit structure of one channel in the dose distribution detection device for particle radiotherapy provided by the present invention.

[0021] Figure 3 This is a schematic diagram of the specific circuit structure of the dose distribution detection device (64 channels) for particle radiotherapy provided by the present invention. Detailed Implementation

[0022] To make the objectives, technical solutions, and advantages of the present invention more clear, the technical solutions of the present invention will be clearly and completely described below in conjunction with the accompanying drawings. Obviously, the embodiments described are only some of the embodiments of the present invention, not all of them. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative efforts shall fall within the scope of protection of the present invention.

[0023] The dose distribution detection device for particle radiotherapy according to embodiments of the present invention, such as Figure 1 As shown, it includes: a multi-channel current-to-voltage conversion circuit 1, an analog-to-digital conversion module 2, a logic control module 3, a dose distribution detector 4, and a host computer 5.

[0024] Each channel of the multi-channel current-to-voltage conversion circuit 1 is a dual-integration architecture circuit including two integration modules. Each channel of the dose distribution detector 4 is connected to one channel of the multi-channel current-to-voltage conversion circuit 1, meaning there is a one-to-one correspondence between the channels of the dose distribution detector 4 and the channels of the multi-channel current-to-voltage conversion circuit 1. The multi-channel current-to-voltage conversion circuit 1 connects the analog-to-digital conversion module 2 and the logic control module 3. The analog-to-digital conversion module 2 is connected to the logic control module 3, and the logic control module 3 is connected to the host computer 5. The logic control module 3 can be an FPGA (Field Programmable Gate Array) or a CPLD (Complex Programmable Logic Device), etc.

[0025] The host computer 5 sends detection-related configuration parameters to the logic control module 3. The logic control module 3, based on these parameters, controls one integrator module to integrate the current pulse signal output by the dose distribution detector 4, while simultaneously controlling another integrator module to output voltage and discharge (discharge occurs after the analog-to-digital converter 2 has acquired the output voltage). That is, while one integrator module performs integration, the other outputs voltage and discharges, with the two modules alternating between integration and voltage output / discharge. The analog-to-digital converter 2 acquires the output voltage, converts it into a digital signal, and sends it to the logic control module 3. The logic control module 3 combines the digital signals into dose distribution data. Specifically, according to the channel definition, the digital signals are grouped sequentially to form dose distribution data, which is then sent to the host computer 5 for display and storage.

[0026] It is understandable that the logic control module 3 contains a program module with built-in detection control functions. The detection-related configuration parameters issued by the host computer 5 are the parameters of this program module. This program module controls the two integrator modules to integrate alternately, output voltage alternately, and discharge according to the detection-related configuration parameters. Among them, the relevant configuration parameters include: the integration time of the integrator module, the acquisition time of the output voltage (for acquisition by the analog-to-digital conversion module 2), and the discharge time (integration time = acquisition time + discharge time). The logic control module 3 controls the action time of the two integrator modules by the action time of each of the two integrator modules.

[0027] After receiving the dose distribution data uploaded by the logic control module 3, the host computer 5 displays the dose status at each position in real time through pixels, thereby realizing the detection of the radiation dose distribution during flash radiotherapy.

[0028] In the dose distribution detection device for particle radiotherapy in this embodiment, each channel of the multi-channel current-voltage conversion circuit 1 is a dual-integration architecture circuit including two integration modules. Each channel is connected to one channel of the dose distribution detector 4. The logic control module 3 controls the two integration modules to alternately perform integration and output voltage and discharge actions, realizing the segmented processing of the continuous current pulse signal of each channel in the dose distribution detector 4 without dead time. Moreover, the segmented voltage signal is quickly digitized by the analog-to-digital conversion module 2 to obtain a digital signal, thereby improving the count rate of dose distribution detection and meeting the requirements of ultra-high dose rate in flash radiotherapy.

[0029] Furthermore, since traditional dose distribution detection devices have low count rates, most can only be adapted to dose distribution detectors that collect ions and output continuous positive current pulse signals. However, dose distribution detectors that collect electrons and output continuous negative current pulse signals collect electrons at a faster speed. The dose distribution detection device for particle radiotherapy in this embodiment can achieve a high count rate, so it can be adapted not only to dose distribution detectors that collect ions, but also to dose distribution detectors that collect electrons. This enables bipolar current pulse signal processing and has advantages such as bipolar signal processing capability, wide application range, and high timeliness.

[0030] In some embodiments, such as Figure 2 As shown, a schematic diagram of the circuit structure of one channel is given. Each channel of the multi-channel current-to-voltage conversion circuit 1 includes: an integral selection switch S. 12 The system comprises a first integrating module 11, a second integrating module 12, and a two-to-one selector 13. The integrating selection switch S... 12 It can be a single-pole double-throw switch.

[0031] The dose distribution detector 4 is controlled by an integral selection switch S. 12 The dose distribution detector 4 connects to the input terminals of the first integration module 11 and the second integration module 12, and each channel is specifically connected to the corresponding channel's integration selection switch S. 12 The input contacts are provided. The two input terminals of the two-to-one selector 13 are respectively connected to the output terminals of the first integration module 11 and the second integration module 12, and the output terminal of the two-to-one selector 13 is connected to the input terminal of the analog-to-digital conversion module 2.

[0032] The logic control module 3 is connected to the integral selection switch S. 12 The system comprises a first integral module 11, a second integral module 12, and a two-to-one selector 13. The logic control module 3 controls the integral selection switch S. 12 One of the integration modules is selected to integrate the current pulse signal output by the dose distribution detector 4, while simultaneously controlling the 2-to-1 selector 13 (logic control module 3 is connected to the SEL terminal of the 2-to-1 selector 13, providing a selection signal S). SEL The output voltage of the other integrator module is selected and discharged through the SEL terminal of the two-to-one selector 13. The output voltage of the other integrator module is then output to the analog-to-digital converter module 2 via the two-to-one selector 13.

[0033] In this embodiment, the integral selection switch S is used. 12The first integrating module 11, the second integrating module 12, and the two-to-one selector 13 form a dual-integration architecture. The logic control module 3 controls the two integrating modules of the dual-integration architecture, enabling the two integrating modules to integrate, collect, and discharge alternately. Specifically, when detecting the dose distribution of ultra-high dose rate beams, a certain channel of the dose distribution detector 4 at the front end outputs the detected current pulse signal. At this time, the logic control module 3 controls the integration selection switch S. 12 The first integrating module 11 is selected for integration, meaning its input is connected to a channel of the dose distribution detector 4, initiating integration. Simultaneously, the logic control module 3 controls the multiplexer 13 to select the output voltage of the second integrating module 12. The voltage V2 output by the second integrating module 12 is then output to the analog-to-digital converter 2 via the multiplexer 13. The analog-to-digital converter 2 acquires the voltage V2 output by the second integrating module 12. After acquisition, the logic control module 3 controls the second integrating module 12 to discharge, reducing its output voltage to 0. After discharge, the logic control module 3 controls the integrating selection switch S. 12 The second integrating module 12 is selected for integration, and the two-to-one selector 13 is controlled to select and discharge the output voltage of the first integrating module 11. That is, the voltage V1 output by the first integrating module 11 is output to the analog-to-digital converter 2 through the two-to-one selector 13. The analog-to-digital converter 2 acquires the voltage V1 output by the first integrating module 11. After the analog-to-digital converter 2 completes the acquisition, the logic control module 3 controls the first integrating module 11 to discharge, discharging the output voltage of the first integrating module 11 to 0. That is, while the logic control module 3 controls one integrating module to integrate, the other integrating module outputs and discharges voltage. The two integrating modules alternately perform the actions of integration and outputting and discharging voltage, realizing the segmented processing of the continuous current pulse signal of each channel of the dose distribution detector 4 without dead time. Moreover, the segmented voltage signal is quickly digitized by the analog-to-digital converter 2 to obtain a digital signal, thereby improving the count rate of dose distribution detection and meeting the requirements of ultra-high dose rate in flash radiotherapy. The logic control module 3 can use this digital signal to form dose distribution data and upload it to the host computer 5 for display and storage.

[0034] In this embodiment, under the dual-integration architecture, the count rate is also related to the sum of the discharge duration and the acquisition duration. The smaller the sum of the discharge duration and the acquisition duration, the larger the count rate, which is more suitable for dose detection during flash radiotherapy. The acquisition duration is determined by the acquisition speed of the analog-to-digital converter module 2. A high-speed analog-to-digital converter (with a sampling rate of not less than 50MHz) can be used to shorten the acquisition time. The discharge duration is determined by the structure and components of the two integration modules. Once the circuit design of the integration modules is completed, the discharge duration is also determined. A design and components with a relatively small discharge duration can be used. The logic control module 3 can then control the two integration modules to execute corresponding action durations according to their respective action durations, thereby improving the count rate.

[0035] Through extensive testing and design improvements to the dose distribution detection device for particle radiotherapy in this embodiment, the sum of the acquisition time and the discharge time can be compressed to about 4.16 μs, thereby achieving a count rate of 240 kJ / s. The higher the count rate, the better the accuracy and timeliness of dose distribution detection, and the more suitable it is for dose distribution detection in ultra-high dose rate flash radiotherapy.

[0036] In some embodiments, the first integration module 11 includes: a first operational amplifier OP1, a first variable capacitor C1, and a first bleeder switch S1. The two ends of the first variable capacitor C1 are respectively connected to the output terminal and the negative input terminal of the first operational amplifier OP1, and the negative input terminal of the first operational amplifier OP1 is connected to the integration selection switch S1. 12 The first selection contact is grounded at its positive input terminal. The first discharge switch S1 is connected in parallel with the first variable capacitor C1, meaning that the two contacts of the first discharge switch S1 are respectively connected to the two ends of the first variable capacitor C1, and the control terminal of the first discharge switch S1 is connected to the logic control module 3. The output terminal of the first operational amplifier OP1 is connected to the first input terminal S of the 2-to-1 selector 13. A .

[0037] Specifically, the logic control module 3 is also connected to the control terminal of the first variable capacitor C1 to control the capacitance value of the first variable capacitor C1. By controlling the capacitance value of the first variable capacitor C1, the input current to the first integration module 11 can be controlled to match the output current pulse signals of each channel of the front-end dose distribution detector 4. By selecting the first discharge switch S1 that can pass a larger current, the first discharge switch S1 can quickly discharge the voltage of the first variable capacitor C1 to 0, thereby reducing the discharge time and increasing the counting rate.

[0038] In some embodiments, the second integration module 12 includes: a second operational amplifier OP2, a second variable capacitor C2, and a second bleeder switch S2. The two ends of the second variable capacitor C2 are respectively connected to the output terminal and the negative input terminal of the second operational amplifier OP2, and the negative input terminal of the second operational amplifier OP2 is connected to the integration selection switch S2. 12 The second selection contact has its positive input terminal grounded. The second discharge switch S2 is connected in parallel with the second variable capacitor C2, and the control terminal of the second discharge switch S2 is connected to the logic control module 3. The output terminal of the second operational amplifier OP2 is connected to the second input terminal S of the 2-to-1 selector 13. B .

[0039] Specifically, the logic control module 3 is also connected to the control terminal of the second variable capacitor C2 to control the capacitance value of the second variable capacitor C2. By controlling the capacitance value of the second variable capacitor C2, the input current to the second integrator module 12 can be controlled to match the channel output current pulse signal of the front-end dose distribution detector. By selecting the second discharge switch S2, which can handle a larger current, the second discharge switch S2 can quickly discharge the voltage of the second variable capacitor C2 to 0, thereby reducing the discharge time and increasing the counting rate.

[0040] In some embodiments, each channel of the multi-channel current-to-voltage conversion circuit 1 further includes an attenuation module. The input of the attenuation module is connected to the output of the 2-to-1 selector 13, and the output of the attenuation module is connected to the input of the analog-to-digital conversion module 2. To increase the counting rate, the analog-to-digital conversion module 2 employs a high-speed analog-to-digital converter. The amplitude of the voltage sampled by the high-speed analog-to-digital converter is typically small, for example, [-1V, 1V]. Therefore, the attenuation module attenuates the amplitude of the voltage output from the 2-to-1 selector 13 (e.g., [-10V, 10V]) to within the voltage sampling range of the high-speed analog-to-digital converter (e.g., [-1V, 1V]), thus preventing damage to the high-speed analog-to-digital converter.

[0041] In some embodiments, the attenuation module can be a T-type attenuation module or a π-type attenuation module, etc. In this embodiment, the attenuation module is a π-type attenuation module, including: a first resistor R1, a second resistor R2, and a third resistor R3. The first end of the first resistor R1 is connected to the output terminal of the 2-to-1 selector 13, the second end of the first resistor R1 is connected to the input terminal of the analog-to-digital conversion module 2, the first end of the second resistor R2 is connected to the first end of the first resistor R1, the first end of the third resistor R3 is connected to the second end of the first resistor R1, and the second ends of the second resistor R2 and the third resistor R3 are respectively grounded.

[0042] Specifically, the resistance values ​​of the first resistor R1, the second resistor R2, and the third resistor R3 are adjusted according to the voltage range collected by the analog-to-digital conversion module 2 and the voltage difference output by the two-to-one selector 13.

[0043] In some embodiments, each channel of the multi-channel current-to-voltage conversion circuit 1 further includes a first voltage follower module, wherein the attenuation module is connected to the output of the two-to-one selector 13 through the first voltage follower module.

[0044] Specifically, the first voltage follower module is used to isolate the preceding and following circuits, preventing the following circuit from affecting the preceding circuit while maintaining the same voltage before and after the first voltage follower module. In this embodiment, the first voltage follower module is a third operational amplifier OP3. The positive input terminal of the third operational amplifier OP3 is connected to the output terminal of a 2-to-1 selector 13, the negative input terminal is grounded, and the output terminal is connected to the input terminal of the attenuation module, i.e. Figure 2 The first terminal of the first resistor R1 is connected to the positive input terminal of the third operational amplifier OP3 and its output terminal.

[0045] In some embodiments, each channel of the multi-channel current-to-voltage conversion circuit 1 further includes a second voltage follower module, wherein the attenuation module is connected to the input terminal of the analog-to-digital conversion module 2 through the second voltage follower module.

[0046] Specifically, the second voltage follower module is used to isolate the preceding and following circuits, preventing the following circuit from affecting the preceding circuit while maintaining the same voltage before and after the second voltage follower module. In this embodiment, the second voltage follower module is a fourth operational amplifier OP4, and the positive input terminal of the fourth operational amplifier OP4 is connected to the output terminal of the attenuation module, i.e. Figure 2 The second terminal of the first resistor R1 is grounded at its negative input terminal and connected to the input terminal of the analog-to-digital converter module 2 at its output terminal. The positive input terminal of the fourth operational amplifier OP4 is connected to its output terminal.

[0047] In some embodiments, as Figure 3 As shown, the N channels of the multi-channel current-to-voltage conversion circuit 1 share a single N-channel analog-to-digital conversion module 2, where N is greater than or equal to 2.

[0048] Since the analog-to-digital conversion module 2 typically has multiple parallel conversion channels, the N channels of the multi-channel current-to-voltage conversion circuit 1 can share one N-channel analog-to-digital conversion module 2. For example, for a 64-channel dose distribution detector 4, which requires connection to a 64-channel current-to-voltage conversion circuit, in this embodiment, two 32-channel analog-to-digital conversion modules 2 are used. The channels of the multi-channel current-to-voltage conversion circuit 1 are divided into two groups of 32 channels each, connected to one 32-channel analog-to-digital conversion module 2. The entire device only requires two analog-to-digital conversion modules 2. The number of analog-to-digital conversion modules 2 in the dose distribution detection device for particle radiotherapy in this embodiment can be determined based on the number of channels of the dose distribution detector 4 and the number of channels of the analog-to-digital conversion module 2.

[0049] In some embodiments, as Figure 3 As shown, all channels of the multi-channel current-to-voltage conversion circuit 1 share a single logic control module 3.

[0050] In this embodiment, by sharing components, the cost and size of the dose distribution detection device used for particle radiotherapy are reduced.

[0051] Through the above description of the embodiments, those skilled in the art can clearly understand that each embodiment can be implemented by means of software plus the necessary general-purpose hardware platform.

[0052] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention, and not to limit them; although the present invention has been described in detail with reference to the foregoing embodiments, those skilled in the art should understand that modifications can still be made to the technical solutions described in the foregoing embodiments, or equivalent substitutions can be made to some of the technical features; and these modifications or substitutions do not cause the essence of the corresponding technical solutions to deviate from the spirit and scope of the technical solutions of the embodiments of the present invention.

Claims

1. A dose distribution detection device for particle radiotherapy, characterized in that: include: Multi-channel current-voltage conversion circuit, analog-to-digital conversion module, logic control module, dose distribution detector and host computer; Each channel of the multi-channel current-voltage conversion circuit is a dual-integration architecture circuit including two integration modules, each channel of the dose distribution detector is respectively connected to a channel of the multi-channel current-voltage conversion circuit, the multi-channel current-voltage conversion circuit is connected to the analog-to-digital conversion module and the logic control module, the analog-to-digital conversion module is connected to the logic control module, and the logic control module is connected to the host computer; The host computer is used to send the detection-related configuration parameters to the logic control module. The logic control module controls one of the integration modules to integrate the current pulse signal output by the dose distribution detector according to the detection-related configuration parameters, and controls the other integration module to output the voltage and discharge it. The analog-to-digital conversion module collects the output voltage and converts it into a digital signal and sends it to the logic control module. The logic control module combines the digital signal into dose distribution data and sends the dose distribution data to the host computer for display and storage.

2. The dose distribution detection device for particle radiotherapy according to claim 1, characterized in that: Each channel of the multi-channel current-to-voltage conversion circuit includes: an integration selection switch, a first integration module, a second integration module and a two-to-one selector, the dose distribution detector is connected to the input ends of the first integration module and the second integration module through the integration selection switch, the two input ends of the two-to-one selector are respectively connected to the output ends of the first integration module and the second integration module, and the output end of the two-to-one selector is connected to the input end of the analog-to-digital conversion module; The logic control module is connected to the integration selection switch, the first integration module, the second integration module and the two-to-one selector, and is used to control the integration selection switch to select one of the integration modules to integrate the current pulse signal output by the dose distribution detector, and at the same time control the two-to-one selector to select the output voltage of the other integration module and discharge it. The output voltage of the other integration module is output to the analog-to-digital conversion module through the two-to-one selector.

3. The dose distribution detection device for particle radiotherapy according to claim 2, characterized in that: The first integration module includes: a first operational amplifier, a first variable capacitor and a first discharge switch, wherein two ends of the first variable capacitor are respectively connected to the output end and the negative input end of the first operational amplifier, the negative input end of the first operational amplifier is connected to the first selection contact of the integration selection switch, and the positive input end is grounded, the first discharge switch is connected in parallel with the first variable capacitor, and the control end of the first discharge switch is connected to the logic control module, and the output end of the first operational amplifier is connected to the first input end of the two-to-one selector.

4. The dose distribution detection device for particle radiotherapy according to claim 2, characterized in that: The second integration module includes: a second operational amplifier, a second variable capacitor and a second discharge switch, the two ends of the second variable capacitor are respectively connected to the output end and the negative input end of the second operational amplifier, the negative input end of the second operational amplifier is connected to the second selection contact of the integration selection switch, and the positive input end is grounded, the second discharge switch is connected in parallel with the second variable capacitor, and the control end of the second discharge switch is connected to the logic control module, and the output end of the second operational amplifier is connected to the second input end of the two-to-one selector.

5. The dose distribution detection device for particle radiotherapy according to claim 2, characterized in that: Each channel of the multi-channel current-to-voltage conversion circuit further includes: an attenuation module, the input end of the attenuation module is connected to the output end of the two-to-one selector, and the output end of the attenuation module is connected to the input end of the analog-to-digital conversion module.

6. The dose distribution detection device for particle radiotherapy according to claim 5, characterized in that: The attenuation module includes: a first resistor, a second resistor and a third resistor, the first end of the first resistor is connected to the output end of the two-to-one selector, the second end of the first resistor is connected to the input end of the analog-to-digital conversion module, the first end of the second resistor is connected to the first end of the first resistor, the first end of the third resistor is connected to the second end of the first resistor, and the second ends of the second resistor and the third resistor are respectively grounded.

7. The dose distribution detection device for particle radiotherapy according to claim 5, characterized in that: Each channel of the multi-channel current-to-voltage conversion circuit further includes: a first voltage follower module, and the attenuation module is connected to the output end of the one-out-of-two selector through the first voltage follower module.

8. The dose distribution detection device for particle radiotherapy according to claim 5, characterized in that: Each channel of the multi-channel current-to-voltage conversion circuit further includes: a second voltage follower module, and the attenuation module is connected to the input end of the analog-to-digital conversion module through the second voltage follower module.

9. The dose distribution detection device for particle radiotherapy according to any one of claims 1 to 8, characterized in that: The N channels of the multi-channel current-voltage conversion circuit share an N-channel analog-to-digital conversion module, where N is greater than or equal to 2.

10. The dose distribution detection device for particle radiotherapy according to any one of claims 1 to 8, characterized in that: All channels of the multi-channel current-voltage conversion circuit share a logic control module.

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