Whole omega-3 fatty acid type euphausia superba oil astaxanthin composite formula

Abstract

The invention overcomes the defects in the prior art, provides a full omega-3 fatty acid type euphausia superba oil astaxanthin compound formula, and aims to endow common food of euphausia superba oil gel candies with health food functions by compounding astaxanthin and linolenic acid components on the basis of natural euphausia superba oil. In order to solve the technical problem, the technical scheme adopted by the invention is as follows: the total omega-3 fatty acid type euphausia superba oil and astaxanthin compound formula comprises the following components: euphausia superba oil, astaxanthin and linolenic acid, the euphausia superba oil with the phospholipid content of 40-56% is selected, and the proportion of the formula is 84%; 10% of astaxanthin oil, wherein the formula accounts for 4%; 12% of 60% alpha-linolenic acid perilla seed oil; the method can be widely applied to the field of health-care products.

Description

Technical Field

[0001] The invention relates to a full ω-3 fatty acid type Antarctic krill oil astaxanthin composite formula, belonging to the technical field of health care products. Background Art

[0002] Krill oil is a dark red or reddish brown transparent oily liquid made from krill through washing, crushing, extraction, concentration, filtration and other steps. It is rich in phospholipid-type ω-3 polyunsaturated fatty acids linked to phosphatidylcholine (PC): natural eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which are a type of anti-inflammatory fatty acid that can maintain a healthy balance of cell membranes and resist toxic, oxidative and inflammatory attacks.

[0003] At present, the international and domestic krill oil products are mainly pure krill oil (or other oils are added), with different content of ingredients (%), and the main indicators are phospholipids, EPA, DHA, astaxanthin, etc. As an emerging food raw material, its above chemical components are beneficial to the metabolism and transportation of triglycerides and cholesterol in blood vessels, and many data show that it can reduce blood lipids. Due to the limitations of krill oil extraction technology and cost, the content of phospholipids, EPA, and DHA in the above ingredients of existing krill oil products is relatively stable, but the content of natural astaxanthin is relatively low, mostly in micrograms (µg / g); as ω-3 polyunsaturated fatty acids, it is a recognized unsaturated fatty acid that is beneficial to lowering blood lipids. Its composition is eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and alpha-linolenic acid (ALA). Krill oil only contains the first two, and does not contain linolenic acid unique to some plants. Summary of the invention

[0004] The present invention overcomes the shortcomings of the prior art and provides a full ω-3 fatty acid type Antarctic krill oil astaxanthin composite formula, which is based on natural krill oil and is compounded with astaxanthin and linolenic acid components, aiming to give the ordinary food of krill oil gel candy the function of health food.

[0005] In order to solve the above technical problems, the technical solution adopted by the present invention is: a full ω-3 fatty acid type Antarctic krill oil astaxanthin composite formula, the ingredients include krill oil, astaxanthin and linolenic acid, Antarctic krill oil with 40% to 56% phospholipid content is selected, accounting for 84% of the formula; 10% astaxanthin oil, accounting for 4% of the formula; 60% α-linolenic acid perilla seed oil, 12%.

[0006] Furthermore, in Antarctic krill oil with a 40% phospholipid content, the protein content is 20%, phospholipids are 40%, choline is 6%, EPA is 12%, DHA is 6%, and astaxanthin is 0.02%.

[0007] Furthermore, the astaxanthin is natural astaxanthin extracted from Haematococcus pluvialis. In Haematococcus pluvialis oil with 10% astaxanthin content, the total astaxanthin content is 10.3%, the protein content is 4.2%, and the carbohydrate content is 5.8%.

[0008] Furthermore, perilla seed oil with a 60% α-linolenic acid content contains 80.6% polyunsaturated fatty acids, 11.5% monounsaturated fatty acids, and 7.9% saturated fatty acids.

[0009] Furthermore, the three raw materials were added into a reactor in proportion, homogenized for 1 hour at normal pressure and 30° C., and capsules were pressed after vacuum evacuation.

[0010] Furthermore, the net content of the capsule is either 750 mg or 500 mg.

[0011] Furthermore, capsules with a net content of 750 mg were prepared by adding 620 mg of Antarctic krill oil with a 40% phospholipid content, accounting for 82.7% of the total formula, 90 mg of perilla seed oil with a 60% α-linolenic acid content, accounting for 12% of the total formula, and 40 mg of astaxanthin oil with a 10% astaxanthin content, accounting for 5.3% of the total formula.

[0012] Furthermore, the main ingredient content of each 750mg capsule is: protein 116mg, phospholipids 248mg, choline 37mg, EPA74mg, DHA37mg, α-linolenic acid 54mg, and astaxanthin 4mg.

[0013] Furthermore, capsules with a net content of 500 mg were prepared by adding 420 mg of Antarctic krill oil with a 56% phospholipid content, accounting for 84% of the total formula, 60 mg of perilla seed oil with a 60% α-linolenic acid content, accounting for 12% of the total formula, and 20 mg of astaxanthin oil with a 10% astaxanthin content, accounting for 4% of the total formula.

[0014] Furthermore, the main ingredient content of each 500 mg capsule is: protein 79 mg, phospholipids 235 mg, choline 29 mg, EPA71 mg, DHA34 mg, α-linolenic acid 36 mg, and astaxanthin 2 mg.

[0015] The functions of each component in the present invention are: 1. Antarctic krill oil It is the main ingredient in the formula, providing the main nutrients protein and phospholipids. Due to the dual effects of hydrophilicity and hydrophobicity of the phospholipids it contains, it is the main raw material for the synthesis of cell membranes and an important carrier of EPA and DHA, which is beneficial to the absorption and utilization of these two unsaturated fatty acids in cell metabolism. The main functions of EPA and DHA are: (1) Promote the excretion of neutral or acidic cholesterol from feces, inhibit the synthesis of lipids and lipoproteins in the liver, reduce plasma cholesterol, triglycerides, LDL, VLDL, and increase HDL.

[0016] (2) Participate in the metabolism of arachidonic acid to produce the prostaglandin compound PGI3, which can dilate blood vessels, resist platelet aggregation, and prevent thrombosis. Therefore, EPA and DHA have the effects of dilating blood vessels, resisting platelet aggregation, and resisting thrombosis, and can prevent and alleviate hyperlipoproteinemia, atherosclerosis, and coronary heart disease.

[0017] 2. Astaxanthin Supplement the deficiency of astaxanthin contained in natural krill oil. Astaxanthin is a ketocarotenoid, with the chemical name of 3,3′-dihydroxy-4,4′-diketo-β,β′-carotene. It is a chain-breaking antioxidant with strong antioxidant capacity. It can remove nitrogen dioxide, sulfide, disulfide, etc. It can effectively prevent the peroxidation of unsaturated fatty acid methyl esters, which is beneficial to the stability of unsaturated fatty acids; it can also reduce lipid peroxidation and effectively inhibit lipid peroxidation caused by free radicals. In the phospholipid environment of krill oil, astaxanthin can exist in a stable esterified state. Since there is a hydroxyl group in the terminal ring structure of astaxanthin, it is easy to form esters with fatty acids and exist stably. The esterified astaxanthin is divided into astaxanthin monoester and astaxanthin diester according to the different fatty acids it binds. After astaxanthin is esterified, its hydrophobicity is enhanced, and the diester is more lipophilic than the monoester; astaxanthin esterified, or forms a complex with protein, will produce a deep red color.

[0018] As a highly effective natural antioxidant, astaxanthin can remove free radicals and improve the body's anti-aging ability. It mainly exerts its comprehensive nutrition and cell stabilization effects on cardiovascular and cerebrovascular, eyes, and skin through its antioxidant effect, among which it is most helpful to the eyes and cardiovascular and cerebrovascular aspects.

[0019] 3. Linolenic acid It is the ω-3 polyunsaturated fatty acid that is lacking in krill oil, and it is also the only ω-3 polyunsaturated fatty acid that cannot be synthesized. It is the structural material of the biological membranes of various tissues in the body, and it is also the precursor for synthesizing a series of prostaglandins in the human body. Prostaglandins have the functions of dilating blood vessels, lowering blood pressure, resisting blood viscosity, and maintaining water balance in the body. They can also relieve inflammation and pain, improve the function of the nervous and immune systems, and help insulin work normally, thereby helping to regulate blood sugar balance. ALA, as the mother of Omega-3 polyunsaturated fatty acids, can be metabolized to produce a variety of highly active substances through carbon chain extension and desaturation reactions under the action of carbon chain extension enzymes and dehydrogenases, among which EPA and DHA are the most important.

[0020] Compared with the prior art, the present invention has the following beneficial effects: the present invention is based on natural krill oil, compounded with astaxanthin and linolenic acid components, aiming to give the ordinary food of krill oil gel candy the function of health food.

[0021] The protein, phospholipids, EPA, DHA, astaxanthin and other ingredients contained in the existing krill oil products have given such products rich nutritional value and conditioning effects on the health of the body, and are natural foods that are popular among sub-healthy people. Since the astaxanthin content in krill mainly comes from the intake and accumulation of marine algae by krill itself, the astaxanthin content of the existing krill oil on the market is mostly around 0.001-0.01%. After compounding of the present invention, the natural astaxanthin content reaches 0.4%, which has a more effective antioxidant effect. The important property of astaxanthin lies in its antioxidant property, and it is an excellent antioxidant. This is because it can stabilize the cell membrane structure, reduce membrane permeability, limit the entry of peroxide promoters into cells, and protect important components in cells such as mitochondria from oxidative damage. Astaxanthin integrated into the membrane system inhibits lipid peroxidation through the protective effect on liposomes, and can also protect myocardial cells and DNA from damage by oxidative reactions, protect proteins in cells, enable cells to metabolize effectively, and enable proteins in cells to function better. This anti-oxidation effect is manifested in prolonging the time for low-density lipoprotein (LDL) to be oxidized, thereby reducing the occurrence of atherosclerosis. In the present invention, the presence of a higher concentration of astaxanthin is beneficial to the stability of unsaturated fatty acids in krill oil, while the phospholipid components in krill oil are beneficial to the stability of astaxanthin in an esterified form.

[0022] EPA and DHA, as components of ω-3 polyunsaturated fatty acids, are known as "blood vessel scavengers" and "biological brain gold". They can slow down cell aging, maintain youthful skin, reduce the rate of brain cell degeneration, and reduce the decline of organ function in the body. The true ω-3 polyunsaturated fatty acids include EPA, DHA and ALA, and the ω-3 fatty acid ALA from plant sources such as perilla seeds and flax can not only provide precursors for EPA and DHA, but also provide energy sources. α-linolenic acid is the only essential fatty acid in the Omega-3 series. It is the structural material of the biological membranes of various tissues in the body and the precursor of a series of prostaglandins synthesized in the human body. Prostaglandins have the functions of dilating blood vessels, lowering blood pressure, resisting blood viscosity, and maintaining water balance in the body. They can also reduce inflammation and pain, improve the function of the nervous and immune systems, and help insulin work normally, thereby helping to regulate blood sugar balance. At the same time, ALA, as the mother of Omega-3 polyunsaturated fatty acids, can be metabolized to produce a variety of highly active substances through carbon chain extension and desaturation under the action of carbon chain extension enzymes and dehydrogenases, of which 10-20% can synthesize other important unsaturated fatty acids EPA and DHA. A large number of animal experiments and physiological and biochemical experiments have proved that ALA has the effect of lowering blood lipids and blood pressure, reducing platelet aggregation and thrombosis, and maintaining the elasticity and integrity of microvascular walls. Therefore, it has a significant effect in preventing and treating cardiovascular diseases; secondly, ALA also has the effect of improving the body's immunity and promoting sperm development. DETAILED DESCRIPTION

[0023] The present invention will be further described below in conjunction with specific embodiments.

[0024] In order to improve the nutritional value and quality of existing Antarctic krill oil products, the present invention compounded krill oil with perilla seed oil and astaxanthin oil.

[0025] The first is to fill the deficiency of the main components of ω-3 unsaturated fatty acids. ω-3 fatty acids are a kind of polyunsaturated fatty acids that are essential to the human body. They are named because their first double bond is located on the third carbon atom from the methyl end. The main members of the ω-3 fatty acid family are octadecatrienoic acid (ALA), eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). ALA is the main component of the brain cell membrane, synapse, myelin sheath, synaptic cleft neurotransmitter, and transmitter receptor structure in the human body. It is the precursor substance for the synthesis of prostaglandins in the human body and the mother of the ω-3 series of polyunsaturated fatty acids. 10-20% can be converted into DHA and EPA in the body. After adding ALA (linolenic acid), the types of ω-3 unsaturated fatty acids can be enriched, which promotes the human body to better absorb and utilize EPA and DHA.

[0026] The added astaxanthin makes up for the lack of astaxanthin in the original krill oil. The bioavailability of the combination of krill oil and astaxanthin is higher than that of pure astaxanthin esters, and is better than the combination of fish oil and astaxanthin esters. The presence of phospholipid-like amphiphilic substances in Antarctic krill oil helps to hydrolyze the esterified astaxanthin in Antarctic krill oil into free astaxanthin and promotes its entry into mixed micelles, so that astaxanthin exhibits better absorption characteristics in the digestive tract.

[0027] The above-mentioned compounded natural raw materials all have chemical and biological homology, good compatibility and stability, can improve each other's bioavailability, are more conducive to the absorption of effective nutrients after consumption, promote the accelerated metabolic transport of triglycerides and cholesterol in blood vessels, have better antioxidant and cell protection effects in the body, and are a very good health food formula.

[0028] The main ingredients of the present invention: Antarctic krill oil, astaxanthin, linolenic acid.

[0029] Recipe ratio: Antarctic krill oil with 56% phospholipid content, accounting for 84% of the formula; 10% astaxanthin oil, accounting for 4% of the formula; 60% α-linolenic acid (ALA) perilla seed oil, accounting for 12%.

[0030] Purpose and preparation requirements of each component 1. Antarctic krill oil It is the main ingredient in the formula, providing the main nutrients such as protein and phospholipids, choline, EPA, DHA, etc. The phospholipids it contains are the hallmark substances of the ingredient content, with both hydrophilic and hydrophobic properties, and are the main raw materials for the synthesis of cell membranes. They are also important carriers of EPA and DHA, which are beneficial to the absorption and utilization of these two unsaturated fatty acids in cell metabolism; EPA and DHA mainly have the effects of vasodilation, anti-platelet aggregation and anti-thrombosis, prevent and alleviate hyperlipoproteinemia, atherosclerosis, coronary heart disease, promote brain and prostate cell metabolism, and stabilize cell activity.

[0031] We use Antarctic krill oil with a 40% phospholipid content, including 20% ​​protein, 40% phospholipids, 6% choline, 12% EPA, 6% DHA, and 0.02% astaxanthin.

[0032] 2. Astaxanthin Supplement the deficiency of astaxanthin contained in the above-mentioned natural krill oil. Astaxanthin is a ketocarotenoid and a chain-breaking antioxidant with extremely strong antioxidant capacity. It can remove nitrogen dioxide, sulfide, disulfide, etc., effectively prevent the peroxidation of unsaturated fatty acid methyl esters, reduce lipid peroxidation, and effectively inhibit lipid peroxidation caused by free radicals. When astaxanthin is added to the phospholipid environment of krill oil, it can exist in a stable esterified state. Since there is a hydroxyl group in the terminal ring structure of astaxanthin, it is easy to form esterification with fatty acids and exist stably. After astaxanthin is esterified, its hydrophobicity is enhanced, which is conducive to binding and entering the cell membrane.

[0033] As a highly effective natural antioxidant, astaxanthin can remove free radicals and improve the body's anti-aging ability. It mainly exerts its comprehensive nutrition and cell stabilization effects on cardiovascular and cerebrovascular, eyes, and skin through its antioxidant effect, among which it is most helpful to the eyes and cardiovascular and cerebrovascular aspects.

[0034] We selected Haematococcus pluvialis oil with 10% astaxanthin content, including 10.3% total astaxanthin (all-trans astaxanthin content / 71.8% total astaxanthin content), 4.2% protein, and 5.8% carbohydrates. 3. Linolenic acid It is the ω-3 polyunsaturated fatty acid that is lacking in krill oil, and it is also the only ω-3 polyunsaturated fatty acid that cannot be synthesized in the human body. It is the structural material of the biological membranes of various tissues in the body, and it is also the precursor for synthesizing a series of prostaglandins in the human body. Prostaglandins have the functions of dilating blood vessels, lowering blood pressure, resisting blood viscosity, and maintaining water balance in the body. They can also relieve inflammation and pain, improve the function of the nervous and immune systems, and help insulin work normally, thereby helping to regulate blood sugar balance. ALA, as the mother of Omega-3 polyunsaturated fatty acids, can be metabolized to produce a variety of highly active substances through carbon chain extension and desaturation reactions under the action of carbon chain extension enzymes and dehydrogenases, among which EPA and DHA are the most important.

[0035] Use perilla seed oil with 60% ALA content, 80.6% polyunsaturated fatty acids, 11.5% monounsaturated fatty acids, and 7.9% saturated fatty acids.

[0036] According to the above formula and raw materials, prepare the full ω-3 fatty acid type Antarctic krill oil astaxanthin compound capsule: To make capsules with a net content of 750mg, add 620mg of Antarctic krill oil with 40% phospholipid content (accounting for 82.7% of the total formula), 90mg of perilla seed oil with 60% ALA content (accounting for 12% of the total formula), and 40mg of astaxanthin oil with 10% astaxanthin content (accounting for 5.3% of the total formula). The main ingredients of each capsule are: protein 116mg, phospholipids 248mg, choline 37mg, EPA74mg, DHA37mg, ALA54mg, astaxanthin 4mg. (1 capsule each time, twice a day) To make capsules with a net content of 500 mg, add 420 mg of Antarctic krill oil with a 56% phospholipid content (accounting for 84% of the total formula), 60 mg of perilla seed oil with a 60% ALA content (accounting for 12% of the total formula), and 20 mg of astaxanthin oil with a 10% astaxanthin content (accounting for 4% of the total formula). The main ingredients of each capsule are: protein 79 mg, phospholipids 235 mg, choline 29 mg, EPA 71 mg, DHA 34 mg, ALA 36 mg, astaxanthin 2 mg. (2-4 capsules per day) The three raw materials were added into the reactor in proportion, homogenized at normal pressure and 30°C for 1 hour, and then pressed into capsules after vacuum evacuation.

[0037] The above is a detailed description in conjunction with the embodiments, but the present invention is not limited to the above embodiments, and various changes can be made within the knowledge scope of ordinary technicians in this field without departing from the purpose of the present invention.

Claims

1. A composite formula of Antarctic krill oil astaxanthin containing all ω-3 fatty acids, characterized in that: The ingredients include krill oil, astaxanthin and linolenic acid. Antarctic krill oil with a phospholipid content of 40% to 56% is used, accounting for 84% of the formula; 10% astaxanthin oil, accounting for 4% of the formula; 60% α-linolenic acid perilla seed oil, accounting for 12%.

2. A composite formula of full ω-3 fatty acid type Antarctic krill oil astaxanthin according to claim 1, characterized in that: Antarctic krill oil with 40% phospholipid content contains 20% protein, 40% phospholipids, 6% choline, 12% EPA, 6% DHA and 0.02% astaxanthin.

3. A composite formula of full ω-3 fatty acid type Antarctic krill oil astaxanthin according to claim 1, characterized in that: The astaxanthin is natural astaxanthin extracted from Haematococcus pluvialis. In Haematococcus pluvialis oil with 10% astaxanthin content, the total astaxanthin content is 10.3%, the protein content is 4.2%, and the carbohydrate content is 5.8%.

4. A composite formula of full ω-3 fatty acid type Antarctic krill oil astaxanthin according to claim 1, characterized in that: Perilla seed oil with 60% α-linolenic acid content contains 80.6% polyunsaturated fatty acids, 11.5% monounsaturated fatty acids, and 7.9% saturated fatty acids.

5. A composite formula of full ω-3 fatty acid type Antarctic krill oil astaxanthin according to claim 1, characterized in that: The three raw materials were added into the reactor in proportion, homogenized for 1 hour at normal pressure and 30°C, and then pressed into capsules after vacuum evacuation.

6. A composite formula of full ω-3 fatty acid type Antarctic krill oil astaxanthin according to claim 5, characterized in that: The net content of the capsule is either 750 mg or 500 mg.

7. A composite formula of full ω-3 fatty acid type Antarctic krill oil astaxanthin according to claim 6, characterized in that: To make capsules with a net content of 750 mg, add 620 mg of Antarctic krill oil with 40% phospholipid content, accounting for 82.7% of the total formula, 90 mg of perilla seed oil with 60% α-linolenic acid content, accounting for 12% of the total formula, and 40 mg of astaxanthin oil with 10% astaxanthin content, accounting for 5.3% of the total formula.

8. A composite formula of full ω-3 fatty acid type Antarctic krill oil astaxanthin according to claim 7, characterized in that: The main ingredients of each 750mg capsule are: protein 116mg, phospholipids 248mg, choline 37mg, EPA74mg, DHA37mg, α-linolenic acid 54mg, and astaxanthin 4mg.

9. A composite formula of full ω-3 fatty acid type Antarctic krill oil astaxanthin according to claim 6, characterized in that: To make capsules with a net content of 500 mg, add 420 mg of Antarctic krill oil with a 56% phospholipid content, accounting for 84% of the total formula, 60 mg of perilla seed oil with a 60% α-linolenic acid content, accounting for 12% of the total formula, and 20 mg of astaxanthin oil with a 10% astaxanthin content, accounting for 4% of the total formula.

10. A composite formula of full ω-3 fatty acid type Antarctic krill oil astaxanthin according to claim 9, characterized in that: The main ingredients of each 500mg capsule are: protein 79mg, phospholipids 235mg, choline 29mg, EPA71mg, DHA34mg, α-linolenic acid 36mg, and astaxanthin 2mg.