Health-care product with weight-losing effect as well as preparation method and application of health-care product

Abstract

The invention discloses a health-care product with a weight-losing effect as well as a preparation method and application of the health-care product. The health-care product is prepared from the following raw materials in parts by weight: 1-5 parts of an aloe extract, 5-10 parts of an acanthopanax sessiliflorus leaf extract, 20-30 parts of pigeon pea natto powder and 40-60 parts of auxiliary materials. Research finds that the aloe extract, the acanthopanax sessiliflorus leaf extract and the pigeon pea natto powder are combined to play an obvious weight-losing role in the aspects of inhibiting lipase activity, regulating lipid metabolism, increasing energy consumption, controlling appetite and the like; by using the pigeon pea natto powder, the diarrhea phenomenon caused by the aloe extract and the acanthopanax sessiliflorus leaf extract can be obviously reduced. The three components and a proper amount of auxiliary materials are compounded to prepare the health-care product, and the health-care product can be used for reducing blood sugar, reducing lipid and losing weight and has the advantages of being natural, green, safe in property, remarkable in effect and small in side effect.

Description

Technical Field

[0001] The invention belongs to the field of health care products, and in particular relates to a health care product with weight loss effect and a preparation method and application thereof. Background Art

[0002] Obesity refers to a certain degree of obvious overweight and excessive fat layer. It is a state caused by the long-term imbalance of calorie intake exceeding energy consumption, resulting in a large amount of fat deposition in adipose tissue. Obesity not only affects a person's work, life and appearance, but also has considerable harm to health. Obesity can easily lead to various chronic diseases, such as type 2 diabetes (T2D), hyperlipidemia, cardiovascular disease (CVD), hypertension, cerebrovascular disease, obstructive sleep apnea, etc.

[0003] At present, a variety of methods can be used to treat obesity, such as dietary changes, exercise, behavioral changes, surgery and drug therapy. Drug treatment is fast and effective; dietary changes are safe and not easy to rebound. Therefore, these two methods are becoming more popular means of weight loss. Although weight loss drugs have obvious effects, they often have more or less safety risks such as side effects. For example, once star drugs such as fenfluramine, rimonabant and sibutramine have been withdrawn from the market due to reports of side effects. Orlistat is another popular and widely recognized weight loss drug. It is the only drug approved by the European Medicines Agency (EMA) in the EU for the management of chronic obesity. Orlistat is mainly used to inhibit lipase activity and can prevent 25% to 30% of fat intake and calorie absorption, but possible liver damage cannot be ignored, and its effect depends on the patient's diet control. Based on the above problems, seeking natural sources, especially food-derived compounds, to inhibit obesity has become one of the current research hotspots in nutrition-related fields. Summary of the invention

[0004] In view of the deficiencies of the prior art, the object of the present invention is to provide a health product with weight loss effect. The present invention has found that the combination of aloe extract, sessile acanthopanax leaf extract and pigeon pea natto powder can play an obvious weight loss effect by inhibiting lipase activity, regulating lipid metabolism, increasing energy consumption, and controlling appetite. In particular, the use of pigeon pea natto powder can significantly reduce the diarrhea caused by aloe extract and sessile acanthopanax leaf extract. The above three ingredients are compounded with appropriate amounts of auxiliary materials to prepare a health product, which can be used for reducing blood sugar, reducing blood lipids, and reducing weight. It has the advantages of being natural and green, safe in nature, having a significant effect, and having few side effects.

[0005] The technical solution of the present invention is:

[0006] A health product with weight loss effect comprises the following raw materials in parts by weight: 1-5 parts of aloe extract, 5-10 parts of sessile acanthopanax leaf extract, 20-30 parts of pigeon pea natto powder and 40-60 parts of auxiliary materials.

[0007] Preferably, the preparation steps of the aloe extract are: drying the aloe vera, crushing it, sieving it, heating and refluxing it with 6 to 8 times the volume fraction of 50 to 60% ethanol solution for 2 to 3 times, each extraction time is 1 to 1.5 hours, filtering and collecting the filtrate, combining the filtrate, and decompressing and concentrating the filtrate to obtain the aloe extract.

[0008] Preferably, the preparation steps of the sessile Acanthopanax leaf extract are: drying and crushing the sessile Acanthopanax leaf, heating and refluxing with 6 to 8 times the volume of 60 to 75% ethanol solution for 2 to 3 times, each time for 1 to 2 hours, combining the extracts and filtering, concentrating the filtrate into an extract, extracting and separating the extract with water and petroleum ether, subjecting the aqueous layer extract to column chromatography with a macroporous adsorption resin, eluting with 10 to 50% ethanol by volume, collecting the 50% ethanol eluate, concentrating, and drying to obtain the sessile Acanthopanax leaf extract.

[0009] Preferably, the preparation steps of the pigeon bean and natto powder are: washing the pigeon bean, adding clean water for high-pressure stewing, cooling to room temperature, inoculating natto bacteria for fermentation, mixing the fermented pigeon bean with probiotics and continuing to ferment, and low-temperature drying and crushing the product to obtain the pigeon bean and natto powder.

[0010] Preferably, the probiotic is at least one of Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus and Lactobacillus paracasei.

[0011] Preferably, the fermentation conditions of the natto bacteria are: first culture at 120-150 r / min, 35-40° C. for 3-6 hours, and then culture at 30-35° C. for 3-6 hours; the fermentation conditions of the probiotics are: culture at 40-45° C. for 1-2 hours.

[0012] Preferably, the auxiliary materials include at least one of a filler, a binder, a disintegrant, a wetting agent and a lubricant.

[0013] Preferably, the dosage form of the health care product includes powder, granules, tablets, pills or capsules.

[0014] The present invention also provides a method for preparing the above health product with weight loss effect, comprising the following steps: mixing aloe extract, Acanthopanax sessile leaf extract, Pigeon pea natto powder and auxiliary materials to prepare a suitable dosage form.

[0015] The present invention also provides the use of the above health care products in reducing blood sugar, reducing blood lipids and losing weight.

[0016] The invention uses 50-60% ethanol aqueous solution by volume to extract aloe vera dry powder. The obtained aloe vera extract contains aloin, aloe-emodin and other ingredients, which can promote fat burning, inhibit intestinal absorption of fat, and enhance fat oxidation and accelerate fat decomposition by activating AMPK (adenosine monophosphate-activated protein kinase) pathway to play a weight loss effect.

[0017] Acanthopanax sessiliflorus is a plant of the genus Acanthopanax of the family Araliaceae. It has the characteristics of unique taste and rich nutrition, and has been approved as a new resource food. There are reports that Acanthopanax sessiliflorus leaves are made into health tea. The Acanthopanax sessiliflorus leaf extract of the present invention is rich in lupine-type triterpenoid saponin compounds, which can inhibit the activity of pancreatic lipase, reduce intestinal fat absorption, and volatilize to reduce lipids and lose weight.

[0018] Pigeon pea natto powder is made from pigeon peas, which are fermented by natto bacteria and probiotics. First, the fermentation of natto bacteria is used to produce ingredients such as nattokinase from the pigeon pea fermentation products. Nattokinase has the function of dissolving blood clots and helps prevent and treat cardiovascular diseases. Pigeon peas fermented by natto bacteria are rich in amino acids, proteins, dietary fiber, minerals and vitamins, which can effectively promote the reproduction of probiotics, so that the prepared pigeon pea natto powder can effectively regulate appetite in the following two ways: 1. Pigeon peas are rich in dietary fiber and protein, which help increase satiety and delay gastric emptying time, thereby helping to control appetite and reduce food intake. Dietary fiber can also help stabilize blood sugar levels after meals and avoid hunger caused by sudden rise and fall of blood sugar. 2. Lactobacillus probiotics can reduce food intake, body weight and fat accumulation by stimulating the release of satiety factors such as CCK and GLP-1, and reducing the secretion of gastric growth hormone.

[0019] The above-mentioned aloe extract, Acanthopanax sessilifolia leaf extract and pigeon pea natto powder play a significant lipid-lowering, blood sugar-lowering and weight-loss effect by inhibiting lipase activity, regulating lipid metabolism, increasing energy consumption, and controlling appetite. On the other hand, since the aloe extract contains anthraquinone compounds such as aloe-emodin, and the sessilifolia leaf extract contains lupein-type saponins, it has a laxative property and can cause certain gastrointestinal irritation reactions, such as diarrhea, increased bowel movements, and other adverse phenomena. Pigeon pea has a certain astringent and antidiarrheal effect, which can help alleviate intestinal inflammatory reactions, especially the pigeon pea natto powder obtained by fermentation treatment, which has a more significant effect on regulating the gastrointestinal tract and can effectively inhibit the gastrointestinal adverse reactions of diarrhea caused by aloe extract and Acanthopanax sessilifolia leaf extract.

[0020] Therefore, the health care product prepared by using aloe extract, Acanthopanax sessilifolia leaf extract and Pigeon pea natto powder as effective ingredients not only has significant blood sugar lowering, lipid lowering and weight loss effects, but also has the advantages of easy availability of raw materials, natural sources, safe properties and small side effects, and has good application prospects. BRIEF DESCRIPTION OF THE DRAWINGS

[0021] Figure 1 The effect of the health food of the present invention on the body weight of obese mice. Compared with the blank group, *** p<0.001; compared with the model group, # p<0.05, ## p<0.01, ### p<0.001.

[0022] Figure 2 The effect of the health food of the present invention on the adipose tissue of obese mice model. Compared with the blank group, *** p<0.001; compared with the model group, # p<0.05, ## p<0.01, ### p<0.001.

[0023] Figure 3 The effect of the health food of the present invention on blood lipids in obese mice model. Compared with the blank group, *** p<0.001; compared with the model group, # p<0.05, ## p<0.01, ### p<0.001. DETAILED DESCRIPTION

[0024] The present invention is further described in detail below in conjunction with the accompanying drawings and specific examples of the specification. The examples are only used to explain the present invention and are not used to limit the scope of the present invention. The test methods used in the following examples are conventional methods unless otherwise specified; the materials and reagents used are reagents and materials that can be obtained from commercial channels unless otherwise specified.

[0025] Example 1

[0026] Preparation of aloe extract: dry the aloe, grind it, pass it through a 40-mesh sieve, use 6 times the volume fraction of 55% ethanol aqueous solution, heat and reflux in a water bath at 70°C for 3 times, each extraction time is 1 hour, filter and collect the filtrate, combine the filtrate, and reduce the pressure to concentrate and dry the filtrate to obtain the aloe extract.

[0027] Example 2

[0028] Preparation of Acanthopanax sessile leaves extract:

[0029] The leaves of Acanthopanax sessile are dried and crushed, and extracted with 8 times the volume fraction of 70% ethanol aqueous solution by heating and reflux for 3 times, each time for 1 hour, and the extracts are combined and filtered, and the filtrate is concentrated into an extract; after the extract is dispersed and suspended in water, 2 times the volume of petroleum ether is added for extraction 3 times, and the aqueous layer extract is subjected to column chromatography using AB-8 macroporous adsorption resin, and eluted with 10% and 50% ethanol aqueous solutions by volume, respectively, and each eluent uses 4 to 6 times the column volume, and the 50% ethanol eluent is collected, concentrated, and dried to obtain the extract of Acanthopanax sessile leaves.

[0030] Example 3

[0031] Preparation of pigeon pea natto powder: After washing the pigeon pea, place it in a high-pressure container, add clean water at a ratio of 200g / L, stew under high pressure at 121°C for 15min, then naturally cool to room temperature, inoculate commercial natto bacteria (purchased from Beijing Chuanxiu Technology Co., Ltd.) at an inoculation amount of 2% of the weight of the pigeon pea raw material, culture at 150r / min, 38°C for 6h, then stand and culture at 35°C for 4h, then separate the fermented pigeon pea, mix the fermented pigeon pea with Lactobacillus plantarum powder, the amount of Lactobacillus plantarum powder added is 1% of the weight of the fermented pigeon pea, stand and culture at 40°C for 1h, and low-temperature dry the product and then crush it to obtain pigeon pea natto powder.

[0032] Example 4

[0033] Safety testing of aloe vera extract and Acanthopanax sessile leaf extract:

[0034] 1. Sample solution preparation:

[0035] 1) dissolving the aloe extract in DMSO to prepare a solution with a concentration of 1 mg / mL;

[0036] 2) dissolving the Acanthopanax sessile leaf extract in DMSO to prepare a solution with a concentration of 1 mg / mL;

[0037] 3) dissolving the aloe vera extract and the Acanthopanax sessile leaf extract in DMSO to prepare a solution with a concentration of both components of 1 mg / mL;

[0038] 2. 3T3-L1 cell toxicity assay

[0039] 3T3-L1 cells were cultured at 6 × 10 4 / mL, 100 μL of cells per well were inoculated into a 96-well plate and cultured for 48 h; the culture medium of the 96-well plate was aspirated, 100 μL of sample solution was added, and control wells and zeroing wells were set at the same time, and cultured for 24 h; 10 μL of CCK-8 staining solution was added to each well, and cultured in a 37°C incubator for 1.5 h; the absorbance value was detected by an ELISA reader at a wavelength of 450 nm to determine the cell activity, and the cell survival rate (%) = (sample group-zeroing group) / (blank group-zeroing group)×100.

[0040] The results showed that whether the aloe vera extract or the sessile Acanthopanax leaf extract was used alone or in combination, the survival rate of 3T3-L1 cells was not significantly different from that of the blank group. This result indicates that the components of the aloe vera extract and the sessile Acanthopanax leaf extract of the present invention are non-cytotoxic and have good safety.

[0041] Example 5

[0042] A health product with weight loss effect comprises the following raw materials in parts by weight: 5 parts of aloe extract, 10 parts of sessile acanthopanax leaf extract, 30 parts of pigeon pea natto powder, 49 parts of starch and 11 parts of maltodextrin.

[0043] Preparation steps: aloe extract, Acanthopanax sessilifolia leaf extract, pigeon pea natto powder, starch and maltodextrin are evenly mixed, and a proper amount of ethanol solution is added to prepare a soft material, which is granulated through an 18-mesh nylon sieve, dried at 60°C, and sieved through a 16-mesh sieve to obtain granules.

[0044] Example 6

[0045] A health product with weight loss effect comprises the following raw materials in parts by weight: 1 part of aloe extract, 5 parts of sessile acanthopanax leaf extract, 20 parts of pigeon pea natto powder, 32 parts of starch and 8 parts of maltodextrin.

[0046] The preparation steps are as in Example 5.

[0047] Example 7

[0048] A health product with weight loss effect comprises the following raw materials in parts by weight: 3 parts of aloe extract, 10 parts of sessile acanthopanax leaf extract, 25 parts of pigeon pea natto powder, 47 parts of starch and 8 parts of maltodextrin.

[0049] The preparation steps are as in Example 5.

[0050] Example 8

[0051] A health product with weight loss effect comprises the following raw materials in parts by weight: 1 part of aloe extract, 5 parts of sessile acanthopanax leaf extract, 20 parts of pigeon pea natto powder, 5 parts of cross-linked sodium carboxymethyl cellulose, 32 parts of microcrystalline cellulose, 1.5 parts of polyvinyl pyrrolidone and 1.5 parts of micro-powder silica gel.

[0052] Preparation steps: weigh the formula amount of aloe extract, Acanthopanax sessilifolia leaf extract, and Cajanus natto powder, use microcrystalline cellulose as a filler, cross-linked sodium carboxymethyl cellulose and polyvinyl pyrrolidone as disintegrants, an appropriate amount of 5% PVP 60% ethanol solution as a binder, and micro powder silica gel as a flow aid, use a fluidized bed to granulate in one step, and then press into tablets to obtain tablets.

[0053] Comparative Example 1

[0054] The health care product of Comparative Example 1 is different from the health care product of Example 5 in that the formula does not contain aloe vera extract, and the other components remain unchanged.

[0055] Comparative Example 2

[0056] The health care product of Comparative Example 2 is different from the health care product of Example 5 in that the formula does not contain the extract of Acanthopanax sessile leaves, and the other components remain unchanged.

[0057] Comparative Example 3

[0058] The health care product of Comparative Example 3 is different from the health care product of Example 5 in that the formula does not contain pigeon pea natto powder, and the other components remain unchanged.

[0059] Comparative Example 4

[0060] The health care product of Comparative Example 4 is different from the health care product of Example 5 in that the formula does not contain aloe extract and pigeon pea natto powder, and the other components remain unchanged.

[0061] Comparative Example 5

[0062] The health care product of Comparative Example 5 is different from the health care product of Example 5 in that the formula does not contain the Acanthopanax sessile leaf extract and Pigeon pea natto powder, and the other components remain unchanged.

[0063] Comparative Example 6

[0064] The health care product of Comparative Example 6 is different from the health care product of Example 5 in that the formula does not contain aloe extract and Acanthopanax sessile leaf extract, and the other components remain unchanged.

[0065] Example 9

[0066] Kunming mice were randomly divided into 10 groups, with 6 mice in each group, and divided into blank control group, Example 5-7 group, and Comparative Example 1-6 group. The mice in Example 5-7 group and Comparative Example 1-6 group were gavaged with the health care products prepared in Example 5-7 and Comparative Example 1-6, and the gavage dose was 2000 mg / kg·bw. The mice in the blank control group were gavaged with an equal volume of normal saline. After administration, each mouse was placed individually in a cage prepared in advance, and blotting paper was placed under the cage to observe the defecation of the mouse. The number of diarrhea times of the mouse within 6 consecutive hours and the time of the first diarrhea were counted, and the data of each group were averaged. The results are shown in Table 1.

[0067] Table 1 Defecation of mice

[0068] Group Diarrhea frequency Time to first diarrhea (min) Blank control group 0 0 Example 5 Group 0 0 Example 6 Group 0 0 Example 7 Group 0 0 Comparative Example 1 0 0 Comparative Example 2 0 0 Comparative Example 3 6.97±1.44 48.5±10.7 Comparative Example 4 2.36±1.05 79.2±8.4 Comparative Example 5 4.84±1.20 61.6±9.8 Comparative Example 6 0 0

[0069] The results in Table 1 show that when the mice were fed with the health products prepared in Examples 5-7 of the present invention, the mice did not have diarrhea, indicating that the health products of the present invention had little irritation to the gastrointestinal tract of mice. As can be seen from Comparative Examples 3-5, the formula does not add pigeon pea natto powder, and the health products prepared by using aloe extract, sessile Acanthopanax leaf extract, or aloe extract and sessile Acanthopanax leaf extract alone, respectively, will cause diarrhea in mice, while the health products added with pigeon pea natto powder can reverse the above phenomenon. The results show that the use of pigeon pea natto powder can significantly reduce the gastrointestinal adverse reaction of diarrhea caused by aloe extract and sessile Acanthopanax leaf extract.

[0070] Example 10

[0071] 1. Experimental methods

[0072] Kunming mice of equivalent weight were selected. After one week of adaptive feeding, the mice were randomly divided into 11 groups, namely blank control group, obesity model group, Example 5-7 group, and Comparative Example 1-6 group, with 12 mice in each group. The mice in the blank control group were fed with ordinary feed (Synergy Biological, XTCON50J), and the mice in the other groups were fed with high-fat feed (Synergy Biological, XTHF60). They were fed continuously for 1 month to establish a nutritional obesity model. After the model was successfully established, each group was gavaged with the health products prepared in Examples 5-7 and Comparative Examples 1-6 from the 31st day. The gavage dose was 2000 mg / kg·bw, once a day. The blank control group and the obesity model group were gavaged with an equal volume of normal saline. During this period, each group ate a fixed amount of food. The blank control group continued to be fed with ordinary feed, and the other groups continued to be fed with high-fat feed. Gavage was continued for 6 weeks. The results are shown in Table 1. 12 hours after the last gavage, the body weight (BW) of the mice was measured. Figure 1 After the experiment, the mice were fasted for 12 hours, anesthetized, and blood was collected from the orbital venous plexus to determine the levels of total cholesterol (TC) and triglyceride (TG) in serum. The results are shown in Figure 3 After the mice were killed by cervical dislocation, the inguinal white adipose tissue (iWAT) and epididymal white adipose tissue (eWAT) were obtained, and the weights of iWAT and eWAT were measured. The results are shown in Figure 2 .

[0073] 2. Experimental results

[0074] 1) Effect on the body weight of mice

[0075] The results showed that compared with the model group, the health care products prepared in Examples 5-7 could effectively reduce the weight of obese mice, and the effect was better than that of the health care products prepared in Comparative Examples 1-6 ( Figure 1 The health care products of Comparative Examples 1-6 respectively use one or two of aloe extract, Acanthopanax sessilifolia leaf extract, and Pigeon pea natto powder as effective ingredients, and their effect of reducing the body weight of mice is weakened. This result shows that the above three ingredients of the present invention have a synergistic effect in inhibiting the weight gain of mice.

[0076] 2) Effects on mouse adipose tissue

[0077] The results showed that compared with the model group, the health care products prepared in Examples 5-7 could effectively inhibit the formation of adipose tissue in obese mice and significantly reduce the weight of iWAT and eWAT, and the effect was better than that of the health care products prepared in Comparative Examples 1-6 ( Figure 2 ). The results showed that the three ingredients of aloe vera extract, Acanthopanax sessilifolia leaf extract, and Cajanus natto powder had a synergistic effect in inhibiting the formation of adipose tissue in mice.

[0078] 3) Effects on blood lipids in mice

[0079] The results showed that compared with the model group, the health care products prepared in Examples 5-7 could significantly reduce the levels of total cholesterol (TC) and triglycerides (TG) in the serum of obese mice, and the effects were better than those prepared in Comparative Examples 1-6 ( Figure 3 The results showed that the three ingredients of aloe vera extract, Acanthopanax sessilifolia leaf extract, and Cajanus natto powder had a synergistic effect in lowering the blood lipid level in mice.

[0080] The above are only preferred embodiments of the present invention. It should be noted that the above preferred embodiments should not be regarded as limiting the present invention, and the protection scope of the present invention should be based on the scope defined by the claims. For ordinary technicians in this technical field, several improvements and modifications can be made without departing from the spirit and scope of the present invention, and these improvements and modifications should also be regarded as the protection scope of the present invention.

Claims

1. A health product with weight loss effect, characterized in that: The invention comprises the following raw materials in parts by weight: 1-5 parts of aloe extract, 5-10 parts of sessile acanthopanax leaf extract, 20-30 parts of pigeon pea natto powder and 40-60 parts of auxiliary materials.

2. The health product with weight loss effect according to claim 1, characterized in that: The preparation steps of the aloe extract are as follows: drying the aloe vera, crushing it, sieving it, heating and refluxing it with 6 to 8 times the volume fraction of 50 to 60% ethanol solution for 2 to 3 times, each extraction time is 1 to 1.5 hours, filtering and collecting the filtrate, combining the filtrate, and decompressing and concentrating the filtrate to obtain the aloe vera extract.

3. The health product with weight loss effect according to claim 1, characterized in that: The preparation steps of the sessile acanthopanax leaf extract are as follows: drying and then crushing the sessile acanthopanax leaf, heating and refluxing and extracting it 2 to 3 times with 6 to 8 times the volume of 60 to 75% ethanol solution, each time for 1 to 2 hours, combining the extracts and filtering, concentrating the filtrate into an extract, extracting and separating the extract with water and petroleum ether, performing column chromatography on the aqueous layer extract with a macroporous adsorption resin, eluting with 10 to 50% ethanol by volume, collecting the 50% ethanol eluate, concentrating, and drying to obtain the sessile acanthopanax leaf extract.

4. The health product with weight loss effect according to claim 1, characterized in that: The preparation steps of the pigeon pea natto powder are as follows: washing the pigeon pea, adding clean water for high-pressure stewing, cooling to room temperature, inoculating natto bacteria for fermentation, mixing the fermented pigeon pea with probiotics and continuing to ferment, and low-temperature drying and crushing the product to obtain the pigeon pea natto powder.

5. The health product with weight loss effect according to claim 4, characterized in that: The probiotics are at least one of Lactobacillus plantarum, Lactobacillus reuteri, Lactobacillus rhamnosus and Lactobacillus paracasei.

6. The health product with weight loss effect according to claim 4, characterized in that: The fermentation conditions of the natto bacteria are: firstly culture at 120-150r / min, 35-40℃ for 3-6h, and then culture at 30-35℃ for 3-6h; the fermentation conditions of the probiotics are: culture at 40-45℃ for 1-2h.

7. The health product with weight loss effect according to claim 1, characterized in that: The auxiliary materials include at least one of a filler, a binder, a disintegrant, a wetting agent and a lubricant.

8. The health product with weight loss effect according to claim 1, characterized in that: The dosage form of the health care product includes powder, granule, tablet, pill or capsule.

9. A method for preparing a health product with weight loss efficacy according to any one of claims 1 to 8, characterized in that: The method comprises the following steps: mixing aloe extract, Acanthopanax sessile leaf extract, pigeon pea natto powder and auxiliary materials to prepare a suitable dosage form.

10. Use of the health product according to any one of claims 1 to 8 in reducing blood sugar, reducing blood lipids and losing weight.

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