Hydrogen-rich toothpaste as well as preparation method and matched packaging shell thereof

Abstract

The invention relates to the technical field of toothpaste, in particular to hydrogen-rich toothpaste as well as a preparation method and a matched packaging shell thereof. The preparation raw materials comprise the following components in parts by weight: 25-50 parts of powder and 33.4-62.3 parts of slurry, the powder comprises a grinding agent, and the slurry is prepared from the following raw materials: a humectant, a sweetening agent, a flavoring agent, a thickening agent, an adhesive, a caries prevention substance, a whitening agent and a foaming agent. According to the invention, microsphere magnesium hydroxide-rich is used as a hydrogen source, hydrogen is released to covered gingiva and mucous membrane synchronously when the toothbrush is used for cleaning teeth, and both radioactivity and gingivitis are improved; meanwhile, according to the matched packaging shell of the hydrogen-rich toothpaste, powder containing slurry and microsphere magnesium hydroxide-rich powder are placed in the cavity 1 and the cavity 2 respectively, final powder and slurry mixing is conducted during use, free loss of hydrogen due to the fact that magnesium hydroxide-rich powder is soaked in the slurry for a long time can be prevented, and the use effect of the hydrogen-rich toothpaste is improved.

Description

Technical Field

[0001] The invention relates to the technical field of toothpaste, and in particular to a hydrogen-rich toothpaste and a preparation method and a matching packaging shell thereof. Background Art

[0002] With the improvement of the quality of life, the patient population of periodontal disease is growing larger and larger, and the age span is wide, which poses a significant problem to people's daily life. As a common oral problem, periodontal disease is mainly manifested by symptoms such as bleeding gums, swelling, ulcers and even continuous bleeding. This disease not only threatens the health of teeth, but may also affect other organs of the body. Bacteria and their products in the periodontal area can easily spread to adjacent or distal organs through the ulcer area, thereby inducing or aggravating other diseases, posing a serious threat to human health. In view of this, the treatment of periodontal disease has become a key issue of concern in the scientific research community. Therefore, it is particularly urgent to develop a new material that is both stable and reliable, has bactericidal and anti-inflammatory capabilities, and maintains a good cleaning effect.

[0003] Chinese patent CN105560074A discloses a toothpaste, which contains hydrogen-rich water with antioxidant and anti-inflammatory effects, and contains excipients such as aloe vera juice, mint oil, and propolis. It not only has the function of cleaning teeth, but also has more significant anti-inflammatory, anti-swelling, pain-relieving, and hemostatic functions. Chinese patent CN109864900A discloses a toothpaste containing vitamin C and hydrogen-rich water, which has the effects of antioxidant, anti-inflammatory, and inhibiting gingival bleeding and swelling and pain. However, the hydrogen in the above toothpaste is easily lost, which reduces the use effect of the toothpaste. Summary of the invention

[0004] In order to solve the problems in the prior art, the first aspect of the present invention provides a hydrogen-rich toothpaste. The raw materials for preparing the toothpaste include, by weight, 25-50 parts of powder and 33.4-62.3 parts of slurry; the powder includes an abrasive, and the raw materials for preparing the slurry include a moisturizer, a sweetener, a flavoring agent, a thickener, an adhesive, an anti-caries agent, a whitening agent and a foaming agent.

[0005] In one embodiment, the raw materials for preparing the slurry include, by weight: 30-50 parts of moisturizer, 1-5 parts of sweetener, 0.1-1 parts of flavoring agent, 0.2-1.5 parts of thickener, 0.1-0.5 parts of adhesive, 0.1-0.5 parts of anti-caries agent, 0.1-0.5 parts of whitening agent, and 1.8-3 parts of foaming agent.

[0006] In one embodiment, the abrasive comprises any one of hydrated silicon dioxide, calcium carbonate, and microsphere-rich magnesium hydroxide.

[0007] In a preferred embodiment, the abrasive is microsphere-rich magnesium hydroxide.

[0008] In one embodiment, the particle size of the microspheres rich in magnesium hydroxide is 3 to 15 μm.

[0009] In one embodiment, the microspheres rich in magnesium hydroxide are prepared by a spray granulation method; the spray granulation method is specifically: magnesium oxide, magnesium hydride, polyethylene glycol and ethanol are mixed and stirred, and then directly sprayed into a spray granulator to obtain microspheres rich in magnesium hydroxide.

[0010] In the present application, the toothpaste prepared by using homemade microsphere-rich magnesium hydroxide as an abrasive reacts with water to generate small molecule hydrogen. Hydrogen can destroy the redox homeostasis of bacterial metabolism to promote the production of intracellular ROS, subsequently induce DNA damage, and ultimately lead to bacterial death; the gas can penetrate the inflamed skin and promote the polarization of early pro-inflammatory M1 macrophages to anti-inflammatory M2 macrophages without affecting the function of M1 macrophages, that is, shorten the wound healing time without affecting the function of immune cells.

[0011] In one embodiment, the mass ratio of magnesium oxide, magnesium hydride, polyethylene glycol and ethanol is 45:2:3:50.

[0012] In one embodiment, the humectant includes at least one of sorbitol and glycerin.

[0013] In a preferred embodiment, the humectant is glycerin.

[0014] In one embodiment, the sweetener includes at least one of xylitol and sucralose.

[0015] In a preferred embodiment, the sweetener is xylitol.

[0016] In one embodiment, the flavoring agent comprises peppermint oil.

[0017] In one embodiment, the thickener includes at least one of cellulose gum, sodium polymethylcellulose, and sodium hydroxycellulose.

[0018] In a preferred embodiment, the thickener is cellulose gum.

[0019] In one embodiment, the binder comprises carrageenan.

[0020] In one embodiment, the anticaries comprises sodium fluoride.

[0021] In one embodiment, the whitening agent comprises titanium dioxide.

[0022] In one embodiment, the foaming agent includes at least one of sodium lauryl sulfate and sodium lauryl sulfate.

[0023] In a preferred embodiment, the foaming agent is sodium lauryl sulfate.

[0024] The second aspect of the present invention provides a method for preparing a hydrogen-rich toothpaste, comprising at least the following steps:

[0025] S1, heating and stirring a thickener, a flavoring agent, a sweetener, sodium fluoride and a humectant to obtain a uniformly mixed solution A;

[0026] S2. After cooling to room temperature, add brightener to solution A and stir evenly, adjusting the pH value to 6-8;

[0027] S3, adding a foaming agent and a binder, stirring and dispersing in a vacuum environment, and then degassing to obtain the slurry;

[0028] S4. When using, mix the slurry and powder to obtain hydrogen-rich toothpaste.

[0029] In one embodiment, the heating and stirring conditions in step S1 are: heating temperature is 50-70°C, stirring rate is 150-200 rpm, and stirring time is 30-60 min; stirring rate in step S2 is 100-150 rpm, and stirring time is 15-30 min.

[0030] In a preferred embodiment, the heating and stirring conditions in step S1 are: heating temperature is 60°C, stirring rate is 180 rpm, and stirring time is 50 min; stirring rate in step S2 is 120 rpm, and stirring time is 20 min.

[0031] In one embodiment, the stirring rate in step S3 is 100-150 rpm, and the stirring time is 5-10 min.

[0032] In a preferred embodiment, the stirring rate in step S3 is 120 rpm / min and the stirring time is 8 min.

[0033] In one embodiment, the degassing time in step S3 is 20-30 min, which can be 20 min, 25 min, or 30 min.

[0034] In a preferred embodiment, the degassing time in step S3 is 20 minutes.

[0035] A third aspect of the present invention provides a matching packaging shell for hydrogen-rich toothpaste, the matching packaging shell comprising a squeeze clip (1), a capsule refill (2) and a gripping clip (3); the squeeze clip (1) is connected to the gripping clip (3) via a rotating shaft (11), and the capsule refill (2) is fixedly mounted on the gripping clip (3) via a positioning pin (31).

[0036] In one embodiment, the capsule refill (2) is provided with a positioning hole (21) corresponding to the positioning tip (31), a cavity 1 (22), a cavity 2 (23) and an extrusion nozzle (24); the cavity 1 (22) and the cavity 2 (23) are connected via a narrow tube (25), and the cavity 2 (23) and the extrusion nozzle (24) are connected via a mixing tube (26).

[0037] In one embodiment, the narrow tube is provided with a heat-pressing sealing point 1; and the contact end of the mixing tube and the extrusion nozzle is provided with a heat-pressing sealing point 2.

[0038] In one embodiment, the extrusion clip (1) is provided with a rotating shaft, a rotating shaft reinforcement rib, an avoidance hole, a plate belly and a pressing area; one side of the plate belly is connected to the rotating shaft through the rotating shaft reinforcement rib, and the other side of the plate belly is provided with a pressing area, and a plurality of avoidance holes are symmetrically arranged on the plate belly.

[0039] In one embodiment, the holding clip is provided with a rotating shaft seat, a plate body, a positioning pin, an extrusion nozzle bayonet and an extrusion block; a rotating shaft seat is provided on one side of the plate body, a rotating shaft slot is provided on the side of the rotating shaft seat, an extrusion nozzle bayonet is provided on the other side of the plate body, a number of positioning pins are symmetrically provided on the plate body, and an extrusion block is provided on the back of the plate body.

[0040] The supporting packaging shell of the hydrogen-rich toothpaste provided by the present invention can be installed once when in use. When in use, first, align the extrusion clip shaft with the shaft sliding groove on the side of the shaft seat on the holding clip, press it in with force, and the end faces on both sides of the shaft push the inner side of the shaft seat. At this time, the distance between the shaft seats increases due to the deformation of the material axially on both sides under force, and the shaft slides into the shaft seat. After entering the shaft seat, the end face of the shaft enters the opening area of ​​the shaft seat, the deformation of the shaft seat is restored, and the spacing is restored. At this time, the extrusion clip is locked by the quasi-holding clip and can rotate along the axis of the shaft.

[0041] Then, the capsule refill is swung to swing the slurry to the bottom, and the capsule refill is inserted so that the positioning pin is aligned with the positioning hole, and the extrusion nozzle is supported on the extrusion nozzle bayonet.

[0042] Finally, press the extrusion clip, and the gap between its plate belly and the holding clip is reduced, and cavity 1 is deformed under pressure, the volume becomes smaller, the pressure increases, and the pre-filled gas pushes open the two hot-pressing sealing points, and the capsule is unsealed. Continue to press the extrusion clip until the gas is exhausted. At this time, the slurry is squeezed into cavity 2 from the narrow tube. Due to the effect of the narrow tube, the slurry outlet rate is relatively high, and at this time it is preliminarily mixed with the powder in cavity 2; continue to squeeze, and the powder and slurry mixture in cavity 2 enters the mixing tube. Due to the effect of fluid viscosity and the pipeline rotation design, the slurry and powder mixture is mixed for the second time, and then flows out from the extrusion port. At this time, it can be used with a toothbrush for adhesion.

[0043] Beneficial Effects

[0044] 1. The hydrogen-rich toothpaste provided by the present invention uses specific microspheres rich in magnesium hydroxide as an abrasive and has obvious anti-inflammatory effects.

[0045] 2. In the present invention, cellulose gum is selected as a thickener, which can effectively improve the stability of hydrogen-rich toothpaste.

[0046] 3. The present invention uses hydrogen-rich abrasive as a hydrogen source, and releases hydrogen to the gums and mucosa covered by the toothbrush when cleaning teeth, thereby improving radiation and pregnancy gingivitis.

[0047] 4. The supporting packaging shell of the hydrogen-rich toothpaste provided by the present invention can avoid the risk of leakage during product storage and transportation by setting hot pressing sealing points in the narrow tube and the mixing tube while meeting the sealing requirements.

[0048] 5. The supporting packaging shell of the hydrogen-rich toothpaste provided by the present invention places the powder containing the slurry and the microsphere-rich magnesium hydroxide in cavity 1 and cavity 2 respectively, and the final powder and slurry are mixed during use, which can prevent the free loss of hydrogen due to the long-term immersion of the rich magnesium hydroxide in the slurry, thereby improving the use effect of the hydrogen-rich toothpaste. BRIEF DESCRIPTION OF THE DRAWINGS

[0049] Figure 1 A schematic diagram of the structure of the supporting packaging shell of the hydrogen-rich toothpaste provided in the embodiment of the present application;

[0050] Figure 2 A schematic diagram of the structure of the extruded clip in the supporting packaging shell of the hydrogen-rich toothpaste provided in the embodiment of the present application;

[0051] Figure 3 A schematic diagram of the structure of a capsule refill in a matching packaging shell of a hydrogen-rich toothpaste provided in an embodiment of the present application;

[0052] Figure 4 A schematic diagram of the structure of the holding clip in the supporting packaging shell of the hydrogen-rich toothpaste provided in the embodiment of the present application;

[0053] Figure 5This is a schematic structural diagram of the back side of the holding clip in the matching packaging shell of the hydrogen-rich toothpaste provided in an embodiment of the present application.

[0054] In the figure: 1. extrusion clip; 11. rotating shaft; 12. rotating shaft reinforcement rib; 13. avoidance hole; 14. plate belly; 15. pressing area; 2. capsule refill; 21. positioning hole; 22 cavity 1; 23. cavity 2; 24. extrusion nozzle; 25. narrow tube; 26. mixing tube; 27. hot pressing sealing point 1; 28. hot pressing sealing point 2; 3. holding clip; 31. rotating shaft seat; 32. rotating shaft slot; 33. plate body; 34. positioning tip; 35. extrusion nozzle bayonet; 36. extrusion block. DETAILED DESCRIPTION

[0055] In order to make the purpose, technical scheme and advantages of the present invention clearer, the present invention is further described in detail below in conjunction with the examples and drawings. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention. The experimental methods for which specific conditions are not specified in the examples are carried out under conventional conditions or conditions recommended by the manufacturer. The reagents or instruments used that do not specify the manufacturer are all conventional products that can be purchased commercially.

[0056] Example 1

[0057] The first aspect of the present embodiment provides a hydrogen-rich toothpaste, wherein the raw materials for preparing the toothpaste include, by weight: 45 parts of powder and 55 parts of slurry; the powder includes an abrasive, and the raw materials for preparing the slurry include, by weight: 45 parts of moisturizer, 5 parts of sweetener, 0.5 parts of flavoring agent, 1 part of thickener, 0.5 parts of adhesive, 0.5 parts of anti-caries agent, 2 parts of whitening agent, and 2 parts of foaming agent.

[0058] The grinding agent is microsphere-rich magnesium hydroxide, and the particle size of the microsphere-rich magnesium hydroxide is 3 to 15 μm.

[0059] The microspheres rich in magnesium hydroxide are prepared by a spray granulation method; the spray granulation method is specifically as follows: magnesium oxide, magnesium hydride, polyethylene glycol and ethanol in a mass ratio of 45:2:3:50 are mixed and stirred, and then directly sprayed into a spray granulator to obtain microspheres rich in magnesium hydroxide.

[0060] The humectant is glycerin.

[0061] The sweetener is xylitol, the flavoring agent includes peppermint oil, and the thickener is cellulose gum.

[0062] The adhesive comprises carrageenan, the anti-caries comprises sodium fluoride, the whitening agent comprises titanium dioxide, and the foaming agent is sodium dodecyl sulfate.

[0063] A second aspect of this embodiment provides a method for preparing a hydrogen-rich toothpaste, comprising at least the following steps:

[0064] S1, heating and stirring a thickener, a flavoring agent, a sweetener, sodium fluoride and a humectant to obtain a uniformly mixed solution A;

[0065] S2. After cooling to room temperature, add brightener to solution A and stir evenly, adjusting the pH value to 6-8;

[0066] S3, adding a foaming agent and a binder, stirring and dispersing in a vacuum environment, and then degassing to obtain the slurry;

[0067] S4. When using, mix the slurry and powder to obtain hydrogen-rich toothpaste.

[0068] The conditions for heating and stirring in step S1 are: heating temperature is 60° C., stirring rate is 180 rpm, and stirring time is 50 min; the stirring rate in step S2 is 120 rpm, and stirring time is 20 min.

[0069] In the step S3, the stirring rate is 120 rpm / min, the stirring time is 8 min, and the degassing time is 20 min.

[0070] A third aspect of the present embodiment provides a matching packaging shell for a hydrogen-rich toothpaste, the matching packaging shell comprising a squeeze clip (1), a capsule refill (2) and a gripping clip (3); the squeeze clip (1) is connected to the gripping clip (3) via a rotating shaft (11), and the capsule refill (2) is fixedly mounted on the gripping clip (3) via a positioning pin (33).

[0071] The capsule refill (2) is provided with a positioning hole (21) corresponding to the positioning pin (33), a cavity 1 (22), a cavity 2 (23) and an extrusion nozzle (24); the cavity 1 (22) and the cavity 2 (23) are connected through a narrow tube (25), and the cavity 2 (23) and the extrusion nozzle (24) are connected through a mixing tube (26). The narrow tube (25) is provided with a hot pressing sealing point 1 (27); the contact end of the mixing tube (26) and the extrusion nozzle (24) is provided with a hot pressing sealing point 2 (28).

[0072] The extrusion clip (1) is provided with a rotating shaft (11), a rotating shaft reinforcement rib (12), an avoidance hole (13), a plate belly (14) and a pressing area (15); one side of the plate belly (14) is connected to the rotating shaft (11) through the rotating shaft reinforcement rib (12), the other side of the plate belly (11) is provided with a pressing area (14), and two avoidance holes (13) are symmetrically provided on the plate belly (11).

[0073] The holding clip (3) is provided with a rotating shaft seat (31), a plate body (33), a positioning pin (34), an extrusion nozzle bayonet (35) and an extrusion block (36); the rotating shaft seat (31) is provided on one side of the plate body (32), a rotating shaft slot (32) is provided on the side of the rotating shaft seat (31), an extrusion nozzle bayonet (35) is provided on the other side of the plate body (33), four positioning pins (34) are symmetrically provided on the plate body (33), and an extrusion block (36) is provided on the back of the plate body (33).

[0074] Figure 1 A schematic structural diagram of a supporting packaging shell for the hydrogen-rich toothpaste provided in this embodiment;

[0075] Figure 2 A schematic diagram of the structure of the extruded clip in the supporting packaging shell of the hydrogen-rich toothpaste provided in this embodiment;

[0076] Figure 3 A schematic diagram of the structure of the capsule refill in the supporting packaging shell of the hydrogen-rich toothpaste provided in this embodiment;

[0077] Figure 4 A schematic diagram of the structure of the gripping clip in the supporting packaging shell of the hydrogen-rich toothpaste provided in this embodiment;

[0078] Figure 5 This is a schematic structural diagram of the back side of the holding clip in the matching packaging shell of the hydrogen-rich toothpaste provided in this embodiment.

[0079] Comparative Example 1

[0080] The specific implementation of this comparative example is the same as that of Example 1, except that the abrasive in this comparative example is magnesium oxide, which is purchased from Hebei Meishen Technology Co., Ltd. for toothpaste-grade polishing agent.

[0081] Performance Testing

[0082] 1. Test of inflammation treatment status.

[0083] Test method: Three healthy 7-week-old rats, weighing (230±20) g, with healthy periodontal examination, were fed routinely for 1 week before the experiment. The fed rats were ligated with silk thread to establish a periodontitis model.

[0084] Rats with periodontitis were brushed with ordinary toothpaste (Yunnan Chinese herbal toothpaste, purchased from Xuanliang Daily Chemicals (Foshan) Co., Ltd.), hydrogen-rich toothpaste prepared in Example 1, and toothpaste prepared in Comparative Example 1 for 15 days, twice a day. The efficacy of hydrogen-rich toothpaste was determined by comparing the plaque area and gingival epithelial pathological observation. The results are as follows:

[0085] (1) After using ordinary toothpaste for 15 days, the severity of gingival inflammation in rats was almost unchanged, and the color of dental plaque did not change significantly. Pathological observation of gingival epithelial cells showed erosion in some areas, and epithelial basal cells proliferated and extended into the deep connective tissue. There were a large number of new capillaries in the connective tissue of the lamina propria, which were dilated and congested, with edema of the surrounding fibrous stroma and a large number of dense inflammatory cells.

[0086] (2) After using the toothpaste prepared in Comparative Example 1 for 15 days, there was no significant change in the gingival inflammation of the rats, and the color of the dental plaque did not change. The pathological observation of the gingival epithelial cells showed erosion in some areas, and the epithelial basal cells proliferated and extended into the deep connective tissue. There were a large number of new capillaries in the connective tissue of the lamina propria, which were dilated and congested, and the surrounding fibrous interstitium was edematous, with a large number of dense inflammatory cells.

[0087] (3) After using the hydrogen-rich toothpaste prepared in Example 1 for 15 days, the redness and swelling of the gums in the experimental group of rats were basically subsided, the dental plaque disappeared significantly, and the gingival bleeding disappeared. Pathological observation of gingival epithelial cells revealed that the cells were only slightly eroded and the proliferation was not obvious.

Claims

1. A hydrogen-rich toothpaste, characterized in that: The raw materials for preparation include, by weight: 25-50 parts of powder and 33.4-62.3 parts of slurry; the powder includes a grinding agent, and the raw materials for preparation of the slurry include a moisturizer, a sweetener, a flavoring agent, a thickener, an adhesive, an anti-caries agent, a whitening agent and a foaming agent.

2. The hydrogen-rich toothpaste according to claim 1, characterized in that The raw materials for preparing the slurry include, by weight: 30-50 parts of moisturizer, 1-5 parts of sweetener, 0.1-1 parts of flavoring agent, 0.2-1.5 parts of thickener, 0.1-0.5 parts of adhesive, 0.1-0.5 parts of anti-caries agent, 0.1-0.5 parts of whitening agent, and 1.8-3 parts of foaming agent.

3. The hydrogen-rich toothpaste according to claim 1, characterized in that The abrasive comprises any one of hydrated silicon dioxide, calcium carbonate, and microsphere-rich magnesium hydroxide.

4. The hydrogen-rich toothpaste according to claim 3, characterized in that The particle size of the microspheres rich in magnesium hydroxide is 3-15 μm.

5. The hydrogen-rich toothpaste according to claim 3 or 4, characterized in that: The microspheres rich in magnesium hydroxide are prepared by a spray granulation method; the spray granulation method specifically comprises: mixing magnesium oxide, magnesium hydride, polyethylene glycol and ethanol and directly spraying them into a spray granulator to obtain microspheres rich in magnesium hydroxide.

6. The hydrogen-rich toothpaste according to claim 5, characterized in that The mass ratio of the magnesium oxide, magnesium hydride, polyethylene glycol and ethanol is 45:2:3:

50.

7. A method for preparing the hydrogen-rich toothpaste according to any one of claims 1 to 6, characterized in that: At least the following steps are included: S1, heating and stirring a thickener, a flavoring agent, a sweetener, sodium fluoride and a humectant to obtain a uniformly mixed solution A; S2. After cooling to room temperature, add brightener to solution A and stir evenly, adjusting the pH value to 6-8; S3, adding a foaming agent and a binder, stirring and dispersing in a vacuum environment, and then degassing to obtain the slurry; S4. When using, mix the slurry and powder to obtain hydrogen-rich toothpaste.

8. The method for preparing hydrogen-rich toothpaste according to claim 7, characterized in that: The conditions for heating and stirring in step S1 are: heating temperature of 50-70°C, stirring rate of 150-200 rpm, and stirring time of 30-60 min; In the step S2, the stirring rate is 100-150 rpm, and the stirring time is 15-30 min.

9. A packaging shell for a hydrogen-rich toothpaste according to any one of claims 1 to 6, characterized in that: The matching packaging shell comprises a squeeze clip (1), a capsule refill (2) and a grip clip (3); the squeeze clip (1) is connected to the grip clip (3) via a rotating shaft (11), and the capsule refill (2) is fixedly mounted on the grip clip (3) via a positioning pin (31).

10. The supporting packaging shell of hydrogen-rich toothpaste according to claim 9, characterized in that: The capsule refill (2) is provided with a positioning hole (21) corresponding to the positioning hole, a cavity 1 (22), a cavity 2 (23) and an extrusion nozzle (24); the cavity 1 (22) and the cavity 2 (23) are connected through a narrow tube (25), and the cavity 2 (23) and the extrusion nozzle (24) are connected through a mixing tube (26).

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