Composition for relieving stomach cold pain as well as preparation method and application thereof

Abstract

The invention provides a composition for relieving stomach cold pain as well as a preparation method and application thereof, and the composition for relieving stomach cold pain is prepared from the following raw materials: pomegranate powder, galangal, black pepper, nutmeg, cinnamon, calcium lactate, sorbitol and magnesium stearate. According to the composition for relieving the stomach cold pain, the galangal, the pomegranate powder, the black pepper, the nutmeg and the cinnamon in a specific proportion are adopted, the effects of invigorating the stomach, removing cold, warming the stomach and nourishing the stomach can be achieved, the stomach cold pain can be well relieved, and therefore the body function of a patient suffering from the stomach cold pain can be conditioned.

Description

Technical Field

[0001] The present invention relates to the technical field of preparations, and in particular to a composition for relieving stomach cold pain. The present invention also relates to a preparation method of the composition for relieving stomach cold pain. The present invention also relates to an application of the composition for relieving stomach cold pain. Background Art

[0002] Cold stomach disease, also known as stomach cold syndrome, is mostly caused by long-term consumption of raw, cold, and hard food. The imbalance of temperature and coolness of the diet causes stagnation in the stomach, which in turn damages the spleen and stomach, causing stomach coldness. Symptoms may include cold pain in the epigastric region, cold and fatigue, loss of appetite, diarrhea, abdominal pain, pale tongue with white coating, etc.

[0003] Chinese herbal medicine resources are rich, and many Chinese medicines are both medicine and food. "Medicine and food are both medicines" means that many foods are medicines, and there is no absolute dividing line between them. Ancient medical scientists applied the theory of "four properties" and "five flavors" of Chinese medicine to food, and believed that each food also has "four properties" and "five flavors". "Medicine and food are both medicines" means that Chinese medicine and food originated at the same time. Compared with Western medicine, Chinese medicine has less toxic side effects and better therapeutic effects. Therefore, it is imperative to invent a composition that can be used to prepare food, functional food, health care products, special diets, and medicines that can improve chills and pain. Summary of the invention

[0004] In view of this, the present invention aims to provide a composition for relieving stomach cold pain, so as to better relieve stomach cold pain.

[0005] To achieve the above object, the technical solution of the present invention is achieved as follows:

[0006] A composition for relieving stomach cold pain. The raw materials for preparing the composition include pomegranate powder, galangal, black pepper, nutmeg, cinnamon, calcium lactate, sorbitol and magnesium stearate.

[0007] Furthermore, the weight portions of each of the raw materials for preparation are: 5-15 parts of pomegranate powder, 10-21 parts of galangal, 2-7 parts of black pepper, 1-6 parts of nutmeg, 1-6 parts of cinnamon, 20-30 parts of calcium lactate, 34-45 parts of sorbitol and 0.5-3 parts of magnesium stearate.

[0008] Furthermore, the weight portions of each of the raw materials for preparation are: 6-14 parts of pomegranate powder, 11-20 parts of galangal, 3-6 parts of black pepper, 2-5 parts of nutmeg, 2-5 parts of cinnamon, 21-29 parts of calcium lactate, 35-44 parts of sorbitol and 1-2.5 parts of magnesium stearate.

[0009] Furthermore, the weight portions of each of the raw materials for preparation are: 7-13 parts of pomegranate powder, 12-19 parts of galangal, 4-5 parts of black pepper, 3-4 parts of nutmeg, 3-4 parts of cinnamon, 22-28 parts of calcium lactate, 36-43 parts of sorbitol and 1-2.5 parts of magnesium stearate.

[0010] Compared with the prior art, the present invention has the following advantages:

[0011] The composition for relieving stomach cold pain of the present invention can play the effects of strengthening the stomach, removing cold, warming the stomach and nourishing the stomach by adopting galangal, pomegranate powder, black pepper, nutmeg and cinnamon in a specific ratio, can well relieve stomach cold pain, and is beneficial to regulating the body functions of patients with stomach cold pain.

[0012] In addition, in the composition of the present invention, pomegranate powder is usually processed from pomegranates, which is sour and sweet, warm in nature, and mainly belongs to the spleen and stomach meridians. And the main function of pomegranate powder focuses on dispelling wind and cold evil and enhancing the yang energy in the stomach. It is mainly used for Bacon cold syndrome, stomach cold syndrome and all stomach diseases. Alpinia officinalis is pungent and hot in nature and belongs to the spleen and stomach meridians. Its pungent and hot nature can warm the spleen and stomach and dispel cold stagnation. It has a significant relieving effect on the cold pain in the abdomen caused by spleen and stomach deficiency and cold, and can effectively improve the vomiting caused by stomach cold, and the symptoms such as belching and acid swallowing caused by the upward reversal of cold air in the stomach.

[0013] Black pepper has a significant pungent and hot nature and belongs to the stomach and large intestine meridians. Its pungent and dispersing nature can dispel the cold evil in the stomach and large intestine, and its warming and hot nature can help the qi of the middle jiao spleen and stomach to move and transform. In terms of functions and indications, for stomach cold vomiting, it can effectively inhibit the vomiting caused by the cold evil rising up; for abdominal pain and diarrhea caused by the cold evil stagnation in the intestines, it can warm the intestinal qi and blood, relieve pain and stop diarrhea; at the same time, for the loss of appetite caused by the cold evil invading the stomach, it can also play the role of appetizing and invigorating the spleen, and promote the recovery of appetite. In addition, in the case of epilepsy with a lot of phlegm, black pepper can help to resolve phlegm and alleviate the condition by virtue of its ability to warm and transform cold phlegm.

[0014] Nutmeg is pungent and warm in nature, and enters the spleen, stomach, and large intestine meridians. Its pungent and warm nature is good at warming the middle and promoting the flow of qi, allowing the spleen and stomach qi to flow smoothly. It also has the function of astringing the intestines and stopping diarrhea, and is very effective for chronic diarrhea caused by spleen and stomach deficiency and cold. Among the symptoms of abdominal distension and pain, nutmeg can relieve the distension and pain caused by qi blockage by warming the middle and promoting the flow of qi; for anorexia and vomiting, it can promote the recovery of the spleen and stomach transportation function, increase appetite, and relieve vomiting symptoms.

[0015] Cinnamon bark is pungent, sweet and hot, and enters the kidney, spleen, heart and liver meridians. It has the effects of replenishing fire and yang, guiding fire back to the origin, dispersing cold and relieving pain, and warming and unblocking the meridians. It is used for symptoms such as impotence, cold uterus, cold pain in the waist and knees, asthma due to kidney deficiency, floating of false yang, dizziness and red eyes, cold pain in the heart and abdomen, vomiting and diarrhea due to deficiency and cold, abdominal pain due to cold hernia, dysmenorrhea and amenorrhea. Cinnamon bark, with its ability to dispel cold and relieve pain, warm and unblock the meridians, effectively dispels cold evil, unclogs the qi and blood meridians, and relieves pain and blockage.

[0016] Pomegranate powder and galangal both belong to the spleen and stomach meridians. Pomegranate powder and galangal work synergistically. Pomegranate powder focuses on warming the stomach yang and harmonizing the middle, while galangal strongly warms and dispels stomach cold and relieves pain. The two work synergistically and promote each other, which can greatly enhance the effects of strengthening the spleen, warming the stomach and relieving pain.

[0017] Black pepper and nutmeg both belong to the stomach and large intestine meridians. Black pepper focuses on warming the middle and dispelling cold, lowering qi and eliminating phlegm, while nutmeg focuses on warming the middle and promoting qi, and astringing the intestines and stopping diarrhea. The combination of the two, for the symptoms of stomach cold and vomiting, the warming and lowering qi of black pepper can cooperate with the warming and promoting qi of nutmeg, and enhance the inhibitory effect on stomach cold and qi reversal; in terms of abdominal pain and diarrhea, the warming and clearing of intestinal cold and nutmeg astringing the intestines and stopping diarrhea work together, which can not only relieve intestinal spasm and pain, but also effectively control the frequency of diarrhea, thereby enhancing the therapeutic effect on stomach cold vomiting, abdominal pain and diarrhea and other symptoms.

[0018] On the basis of pomegranate powder, galangal, black pepper and nutmeg, cinnamon is added, which belongs to the kidney meridian and plays an important role in warming and tonifying kidney yang and warming and unblocking the meridians. The kidney is the innate foundation, and the spleen and stomach are the acquired foundation. The composition of the present invention organically combines tonifying kidney yang with strengthening spleen and stomach, and takes a two-pronged approach from the innate and acquired aspects, which has the effect of treating both the symptoms and the root causes of stomach cold and stomach pain, so that the functions of the internal organs of the human body are gradually restored to balance and coordination, and promote the improvement and enhancement of the overall health status.

[0019] The composition of the present invention adopts raw materials that are both medicinal and edible. Compared with simple drugs, its safety is more guaranteed and its side effects are smaller. Besides, while exerting its medicinal value, it can also provide certain nutrients for the human body.

[0020] Another object of the present invention is to provide a method for preparing a composition, the preparation method comprising:

[0021] Weigh pomegranate powder, galangal, black pepper, nutmeg, cinnamon, calcium lactate, sorbitol and magnesium stearate according to weight;

[0022] Grinding the weighed galangal, black pepper, nutmeg and cinnamon to obtain a powder;

[0023] The powder is mixed with pomegranate powder, calcium lactate and sorbitol to obtain a premixed powder;

[0024] adding a binder to the premixed powder to prepare uniform wet granules;

[0025] drying the wet granules to obtain dry premix granules;

[0026] The premix granules are mixed with magnesium stearate to obtain a total mixed powder of the composition.

[0027] Furthermore, it includes at least one of the following features: (a) the particle size of the powder is between 100 mesh and 150 mesh; (b) the binder is 95% ethanol; (c) the water content of the premix particles is not more than 7.5%.

[0028] Furthermore, the step of crushing the weighed raw materials to obtain powder includes: crushing the weighed raw materials multiple times, and sieving the crushed raw materials after each crushing.

[0029] Furthermore, the preparation method further comprises: tableting the total mixed powder according to a preset weight, and coating the tableted composition.

[0030] Furthermore, the preset weight is 0.49 g / tablet, and the weight difference limit requirement is ±5%.

[0031] Compared with the prior art, the present invention has the following advantages:

[0032] The preparation method of the composition of the present invention uses 95% ethanol as a binder for wet granules to prepare a wet soft material and granulate. Since ethanol has moderate volatility, it can effectively bind the raw materials to form wet granules of regular shape and uniform size during the granulation process, which is convenient for subsequent processing, and can also evaporate quickly in the subsequent drying step, without leaving too many impurities to affect the purity and quality of the product. Moreover, during granulation, the raw materials are fully mixed under the action of the binder, which further ensures that the components are evenly distributed in each particle, avoiding the problem of unstable product efficacy or inconsistent taste caused by local component concentration differences.

[0033] Drying the wet granules and controlling the moisture content to no more than 7.5% can effectively prevent the product from becoming moldy, caking, or deteriorating, ensuring the stability of the product during storage and transportation and extending the shelf life of the product. At the same time, precise moisture control also helps maintain the product's solubility, taste, and activity of each ingredient, ensuring that the product can achieve the best effect when used.

[0034] Tableting and coating the total mixture are beneficial to controlling the dosage of the composition, and the coating process can not only protect the flaky composition from the influence of factors such as moisture and oxygen in the air, thereby increasing the stability of the tablets, but also control the release rate of the drug in the body, allowing it to be slowly released within a specific period of time, thereby improving the efficacy of the drug. At the same time, it can also make the appearance of the tablets more beautiful, increase patient acceptance, effectively isolate external pollutants such as dust and bacteria, and ensure the hygiene and safety of the drugs.

[0035] Another object of the present invention is to provide an application of the above composition in the preparation of food, functional food, health product, special diet or medicine for improving chills and pain.

[0036] In the present invention, by applying the above-mentioned composition to the preparation of foods, functional foods, health products, special diets and medicines for improving chills and pain, the related foods or medicines containing the composition have the effects of strengthening the stomach and removing cold, warming the stomach and nourishing the stomach, can well relieve stomach pain caused by cold, and are beneficial to regulating the body functions of patients with stomach pain caused by cold. BRIEF DESCRIPTION OF THE DRAWINGS

[0037] The accompanying drawings constituting a part of the present invention are used to provide a further understanding of the present invention. The exemplary embodiments of the present invention and their descriptions are used to explain the present invention and do not constitute an improper limitation of the present invention. In the accompanying drawings:

[0038] Figure 1 The overall process flow diagram of the preparation method of the composition described in the embodiment of the present invention is as follows; DETAILED DESCRIPTION

[0039] It should be noted that, in the absence of conflict, the embodiments of the present invention and the features in the embodiments may be combined with each other.

[0040] The present invention will be described in detail below with reference to the accompanying drawings and in conjunction with embodiments.

[0041] The invention relates to a composition for relieving stomach cold pain, which can play the effects of strengthening the stomach, removing cold, warming the stomach and nourishing the stomach, and can well relieve stomach cold pain, thereby being beneficial to regulating the body functions of patients with stomach cold pain.

[0042] In terms of overall design, the raw materials for preparing the composition include pomegranate powder, galangal, black pepper, nutmeg, cinnamon, calcium lactate, sorbitol and magnesium stearate.

[0043] As a preferred embodiment, in the composition for relieving stomach cold pain of the present invention, the weight parts of each preparation raw material are: 5-15 parts of pomegranate powder, 10-21 parts of galangal, 2-7 parts of black pepper, 1-6 parts of nutmeg, 1-6 parts of cinnamon, 20-30 parts of calcium lactate, 34-45 parts of sorbitol and 0.5-3 parts of magnesium stearate.

[0044] Among them, in the composition of the present invention, pomegranate powder is usually processed from pomegranate, which is sour and sweet, warm in nature, and mainly enters the spleen and stomach meridians. And the main function of pomegranate powder focuses on dispelling wind and cold evil and improving the yang energy in the stomach. It is mainly used for Bacon cold syndrome, stomach cold syndrome and all stomach diseases. In specific implementation, the weight parts of pomegranate powder can be set to 5 parts, 6 parts, 7 parts, 8 parts, 9 parts, 10 parts, 11 parts, 12 parts, 13 parts, 14 parts or 15 parts, for example.

[0045] In the composition of the present invention, Alpinia officinalis is pungent and hot, belonging to the spleen and stomach meridians. Its pungent and hot nature can warm the spleen and stomach and dispel cold stagnation. It has a significant relieving effect on cold pain in the abdomen caused by spleen and stomach deficiency and cold, and can effectively improve vomiting caused by stomach cold, and belching and acid swallowing caused by cold air in the stomach. In the specific implementation, the weight of Alpinia officinalis can be set to 10 parts, 11 parts, 12 parts, 13 parts, 14 parts, 15 parts, 16 parts, 17 parts, 18 parts, 19 parts, 20 parts or 21 parts, for example.

[0046] It should be noted that pomegranate powder and galangal both belong to the spleen and stomach meridians, and pomegranate powder and galangal have synergistic effects. Pomegranate powder focuses on warming the stomach yang and harmonizing the middle, while galangal strongly warms and dispels stomach cold and relieves pain. The two work together and promote each other, which can greatly enhance the effects of strengthening the spleen, warming the stomach and relieving pain.

[0047] In the composition of the present invention, black pepper has a significant pungent and hot nature and is in the stomach and large intestine meridians. Its pungent and dispersing nature can dispel the cold pathogen in the stomach and large intestine, and its warming and hot nature can help the transportation and transformation of the qi of the middle-jiao spleen and stomach. In terms of function and indications, for stomach cold vomiting, it can effectively inhibit the vomiting caused by the upward reversal of the cold pathogen; for abdominal pain and diarrhea caused by the stagnation of the cold pathogen in the intestine, it can warm the intestinal qi and blood, relieve pain and stop diarrhea; at the same time, for the loss of appetite caused by the cold pathogen invading the stomach, it can also play the role of appetizing and invigorating the spleen, and promote the recovery of appetite. In addition, in the disease of epilepsy with a lot of phlegm, black pepper can rely on its power of warming and transforming cold phlegm to assist in phlegm transformation to alleviate the condition. And in the specific implementation, the weight of black pepper can be set to 2 parts, 3 parts, 4 parts, 5 parts, 6 parts or 7 parts, for example.

[0048] In the composition of the present invention, nutmeg is pungent and warm in nature, and is in the spleen, stomach, and large intestine meridians. Its pungent and warm nature is good at warming the middle and promoting the flow of qi, so that the qi of the spleen and stomach can run smoothly. Because it has the function of astringing the intestines and stopping diarrhea, it has a good effect on chronic diarrhea caused by spleen and stomach deficiency and cold. In the symptoms of abdominal distension and pain, nutmeg can relieve the distension and pain caused by qi blockage by warming the middle and promoting the flow of qi; for anorexia and vomiting, it can promote the recovery of spleen and stomach transportation and transformation functions, increase appetite, and alleviate vomiting symptoms. And in a specific implementation, the weight of nutmeg can be set to 1 part, 2 parts, 3 parts, 4 parts, 5 parts or 6 parts, for example.

[0049] In the composition of the present invention, cinnamon bark is pungent, sweet and hot, and it enters the kidney, spleen, heart and liver meridians. It has the effects of replenishing fire and supporting yang, guiding fire back to the origin, dispersing cold and relieving pain, and warming and unblocking the meridians, and is used for impotence, cold uterus, cold pain in the waist and knees, asthma caused by kidney deficiency, floating of virtual yang, dizziness and red eyes, cold pain in the heart and abdomen, vomiting and diarrhea caused by deficiency and cold, abdominal pain caused by cold hernia, dysmenorrhea and amenorrhea. Cinnamon bark relies on its ability to dispel cold and relieve pain, warm and unblock the meridians, effectively dispel cold pathogens, unclog the qi and blood meridians, and relieve pain and blockage. In specific implementation, the weight of cinnamon bark can be set to 1 part, 2 parts, 3 parts, 4 parts, 5 parts or 6 parts, for example.

[0050] It should be pointed out that both black pepper and nutmeg belong to the stomach and large intestine meridians. Black pepper focuses on warming the middle and dispelling cold, lowering qi and eliminating phlegm, while nutmeg focuses on warming the middle and promoting qi, and astringing the intestines to stop diarrhea. The combination of the two, for the symptoms of stomach cold and vomiting, the warming and lowering qi of black pepper can cooperate with the warming and promoting qi of nutmeg, and enhance the inhibitory effect on stomach cold and qi reversal; in terms of abdominal pain and diarrhea, the warming and unblocking of intestinal cold stagnation of black pepper and the astringent and stopping diarrhea of ​​nutmeg cooperate with each other, which can not only relieve intestinal spasm and pain, but also effectively control the frequency of diarrhea, thereby enhancing the therapeutic effect on stomach cold vomiting, abdominal pain and diarrhea and other symptoms.

[0051] On the basis of pomegranate powder, galangal, black pepper and nutmeg, cinnamon is added, which belongs to the kidney meridian and plays an important role in warming and tonifying kidney yang and warming and unblocking the meridians. The kidney is the innate foundation, and the spleen and stomach are the acquired foundation. The composition of the present invention organically combines tonifying kidney yang with strengthening spleen and stomach, and takes a two-pronged approach from the innate and acquired aspects, which has the effect of treating both the symptoms and the root causes of stomach cold and stomach pain, so that the functions of the internal organs of the human body are gradually restored to balance and coordination, and promote the improvement and enhancement of the overall health status.

[0052] In addition, in the composition of the present invention, calcium lactate and sorbitol mainly play the role of improving the mouthfeel of the composition, and calcium lactate has a high calcium content, which can supplement the calcium element required by the human body. Sorbitol can be used as an excipient to help drug molding. Especially when making tablets, sorbitol can make drug particles better combined together, which is convenient for tableting. And in the specific implementation, the weight parts of calcium lactate can be set to 20 parts, 22 parts, 25 parts, 27 parts or 30 parts, and the weight parts of sorbitol can be set to 34 parts, 36 parts, 38 parts, 40 parts, 42 parts or 45 parts, for example.

[0053] In the composition of the present invention, magnesium stearate is used to change the binding force between the particles of the auxiliary materials (i.e., calcium lactate and sorbitol) and change the tableting properties of the auxiliary materials. In specific implementation, the weight proportion of magnesium stearate can be set to, for example, 0.5 parts, 1.0 parts, 1.5 parts, 2.0 parts, 2.5 parts or 3.0 parts.

[0054] As a further preferred embodiment, in the composition of the present invention, the weight parts of each raw material are: 6-14 parts of pomegranate powder, 11-20 parts of galangal, 3-6 parts of black pepper, 2-5 parts of nutmeg, 2-5 parts of cinnamon, 21-29 parts of calcium lactate, 35-44 parts of sorbitol and 1-2.5 parts of magnesium stearate. At this time, the composition can play the effect of strengthening the stomach and removing cold and warming the stomach by using a specific ratio of galangal, pomegranate powder, black pepper, nutmeg and cinnamon, and can further relieve stomach cold pain, thereby helping to regulate the body functions of patients with stomach cold pain.

[0055] Also as a further preferred embodiment, in the composition of the present invention, the weight parts of each raw material are: 7-13 parts of pomegranate powder, 12-19 parts of galangal, 4-5 parts of black pepper, 3-4 parts of nutmeg, 3-4 parts of cinnamon, 22-28 parts of calcium lactate, 36-43 parts of sorbitol and 1-2.5 parts of magnesium stearate. At this time, the composition can play the effect of strengthening the stomach and removing cold and warming the stomach by using a specific ratio of galangal, pomegranate powder, black pepper, nutmeg and cinnamon, and can better relieve stomach cold pain, thereby helping to regulate the body functions of patients with stomach cold pain.

[0056] The composition for relieving stomach cold pain of the present invention adopts raw materials that are both medicinal and edible. Compared with simple drugs, its safety is more guaranteed and its side effects are smaller. Besides, while exerting its medicinal value, it can also provide certain nutrients for the human body.

[0057] In addition, this embodiment also relates to a method for preparing a composition, which comprises the following steps:

[0058] Step S1, weighing pomegranate powder, galangal, black pepper, nutmeg, cinnamon, calcium lactate, sorbitol and magnesium stearate according to weight.

[0059] Step S2: Grind the weighed galangal, black pepper, nutmeg and cinnamon to obtain a powder, wherein the particle size of the powder is between 100 meshes and 150 meshes.

[0060] As one of the preferred implementations, in this embodiment, in step S2, it specifically includes: crushing the symmetrically taken raw materials for multiple times, and screening the crushed raw materials after each crushing.

[0061] In the specific implementation, the weighed galangal, black pepper, nutmeg and cinnamon are placed in a grinder and crushed for 10 minutes to obtain a pre-powder. Then the preliminary powder is filtered and screened using a sieve, and the pre-powder remaining on the sieve after screening is further ground and crushed by a grinder, and then filtered and screened again until the amount remaining on the sieve is less than 5% of the total amount, and finally a powder with a particle size between 00 mesh and 150 mesh is obtained.

[0062] Step S3: mixing the powder with pomegranate powder, calcium lactate and sorbitol to obtain a premixed powder.

[0063] In this step, the powder, pomegranate powder, calcium lactate and sorbitol are placed in a high-speed stirrer for mixing. In the specific implementation, the speed of the high-speed stirrer can be set to 1600r / min, and the stirring is performed for 3min-5min until the mixture is uniform to obtain a premixed powder.

[0064] Step S4: adding a binder to the premixed powder to prepare uniform wet granules.

[0065] In this step, the binder is 95% ethanol. In specific implementation, the premixed powder is mixed with 95% ethanol to form uniform wet granules. In the present invention, 95% ethanol is used as a binder for wet granules to prepare wet soft materials and granulate them. Because ethanol has moderate volatility, it can effectively bond the raw materials to form wet granules with regular shapes and uniform sizes during the granulation process, which is convenient for subsequent processing, and can evaporate quickly in the subsequent drying step without leaving too many impurities to affect the purity and quality of the product. Moreover, during granulation, the raw materials are fully mixed under the action of the binder, which further ensures that the ingredients are evenly distributed in each granule, avoiding the problem of unstable product efficacy or inconsistent taste caused by local ingredient concentration differences.

[0066] Step S5: Drying the wet granules to obtain dry premix granules.

[0067] In specific implementation, the wet particles are placed in an oven for drying to obtain dry premix particles, wherein the moisture content of the premix particles is not more than 7.5%. This can effectively prevent the product from mildewing, caking, deterioration, etc., ensure the stability of the product during storage and transportation, and extend the shelf life of the product. At the same time, precise moisture control also helps to maintain the product's reconstitution, taste and activity of each ingredient, ensuring that the product can achieve the best effect when used.

[0068] Step S6: mixing the premix granules with magnesium stearate for 18-22 minutes to obtain a total mixed powder of the composition.

[0069] In addition, the preparation method of this embodiment also includes the following steps:

[0070] Step S7, compressing the total mixed powder into tablets according to a preset weight, wherein the preset weight is 0.49 g / tablet, and the weight difference limit requirement is ±5%.

[0071] Step S8, coating the tableted composition.

[0072] By tableting and coating the total mixture, it is beneficial to control the dosage of the composition, and the coating process can not only protect the flaky composition from the influence of factors such as moisture and oxygen in the air, thereby increasing the stability of the tablets, but also control the release rate of the drug in the body, allowing it to be slowly released within a specific period of time, thereby improving the efficacy of the drug. At the same time, it can also make the appearance of the tablets more beautiful, increase patient acceptance, effectively isolate external pollutants such as dust and bacteria, and ensure the hygiene and safety of the drugs.

[0073] Here, the present invention is further described in conjunction with specific embodiments:

[0074] Example 1

[0075] A composition for relieving stomach cold pain comprises the following raw materials in parts by weight: 10 parts of pomegranate powder, 16 parts of galangal, 5 parts of black pepper, 2.5 parts of nutmeg, 2.5 parts of cinnamon, 24 parts of calcium lactate, 38 parts of sorbitol and 2 parts of magnesium stearate.

[0076] The preparation method of the composition for relieving stomach cold pain comprises the following steps:

[0077] Step S1, weighing pomegranate powder, galangal, black pepper, nutmeg, cinnamon, calcium lactate, sorbitol and magnesium stearate according to weight.

[0078] Step S2: Grind the weighed galangal, black pepper, nutmeg and cinnamon to obtain a powder, wherein the particle size of the powder is between 100 meshes and 150 meshes.

[0079] Step S3: mixing the powder with pomegranate powder, calcium lactate and sorbitol to obtain a premixed powder.

[0080] Step S4: adding a binder to the premixed powder to prepare uniform wet granules.

[0081] Step S5: Drying the wet granules to obtain dry premix granules.

[0082] Step S6: mixing the premix granules with magnesium stearate for 18-22 minutes to obtain a total mixed powder of the composition.

[0083] Step S7, compressing the total mixed powder into tablets according to a preset weight, wherein the preset weight is 0.49 g / tablet, and the weight difference limit is required to be ±5%.

[0084] Step S8, coating the tableted composition.

[0085] Example 2

[0086] A composition for relieving stomach cold pain comprises the following raw materials in parts by weight: 15 parts of pomegranate powder, 21 parts of galangal, 7 parts of black pepper, 6 parts of nutmeg, 6 parts of cinnamon, 20 parts of calcium lactate, 25 parts of sorbitol and 2 parts of magnesium stearate.

[0087] The preparation method of the composition for relieving stomach cold pain in this embodiment is the same as that in Example 1.

[0088] Example 3

[0089] A composition for relieving stomach cold pain comprises the following raw materials in parts by weight: 13 parts of pomegranate powder, 19 parts of galangal, 6 parts of black pepper, 5 parts of nutmeg, 5 parts of cinnamon, 22 parts of calcium lactate, 33 parts of sorbitol and 2 parts of magnesium stearate.

[0090] The preparation method of the composition for relieving stomach cold pain in this embodiment is the same as that in Example 1.

[0091] Example 4

[0092] A composition for relieving stomach cold pain comprises the following raw materials in parts by weight: 8 parts of pomegranate powder, 13 parts of galangal, 2.5 parts of black pepper, 2 parts of nutmeg, 2 parts of cinnamon, 28 parts of calcium lactate, 42.5 parts of sorbitol and 2 parts of magnesium stearate.

[0093] The preparation method of the composition for relieving stomach cold pain in this embodiment is the same as that in Example 1.

[0094] Example 5

[0095] A composition for relieving stomach cold pain comprises the following raw materials in parts by weight: 7 parts of pomegranate powder, 11 parts of galangal, 2 parts of black pepper, 1 part of nutmeg, 1 part of cinnamon, 30 parts of calcium lactate, 45 parts of sorbitol and 3 parts of magnesium stearate.

[0096] The preparation method of the composition for relieving stomach cold pain in this embodiment is the same as that in Example 1.

[0097] Comparative Example 1

[0098] A composition comprises the following raw materials in parts by weight: 16 parts of galangal, 5 parts of black pepper, 2.5 parts of nutmeg, 2.5 parts of cinnamon, 24 parts of calcium lactate, 38 parts of sorbitol and 2 parts of magnesium stearate.

[0099] The preparation method of the composition comprises the following steps:

[0100] Step S1, weighing galangal, black pepper, nutmeg, cinnamon, calcium lactate, sorbitol and magnesium stearate according to weight.

[0101] Step S2: Grind the weighed galangal, black pepper, nutmeg and cinnamon to obtain a powder, wherein the particle size of the powder is between 100 meshes and 150 meshes.

[0102] Step S3: mixing the powder, calcium lactate and sorbitol to obtain a premixed powder.

[0103] Step S4: adding a binder to the premixed powder to prepare uniform wet granules.

[0104] Step S5: Drying the wet granules to obtain dry premix granules.

[0105] Step S6: mixing the premix granules with magnesium stearate for 18-22 minutes to obtain a total mixed powder of the composition.

[0106] Step S7, compressing the total mixed powder into tablets according to a preset weight, wherein the preset weight is 0.49 g / tablet, and the weight difference limit requirement is ±5%.

[0107] Step S8, coating the tableted composition.

[0108] Comparative Example 2

[0109] A composition comprises the following raw materials in parts by weight: 10 parts of pomegranate powder, 5 parts of black pepper, 2.5 parts of nutmeg, 2.5 parts of cinnamon, 24 parts of calcium lactate, 38 parts of sorbitol and 2 parts of magnesium stearate.

[0110] The preparation method of the composition comprises the following steps:

[0111] Step S1, weighing pomegranate powder, black pepper, nutmeg, cinnamon, calcium lactate, sorbitol and magnesium stearate according to weight.

[0112] Step S2, crushing the weighed black pepper, nutmeg and cinnamon to obtain a powder, wherein the particle size of the powder is between 100 meshes and 150 meshes.

[0113] Step S3: mixing the powder with pomegranate powder, calcium lactate and sorbitol to obtain a premixed powder.

[0114] Step S4: adding a binder to the premixed powder to prepare uniform wet granules.

[0115] Step S5: Drying the wet granules to obtain dry premix granules.

[0116] Step S6: mixing the premix granules with magnesium stearate for 18-22 minutes to obtain a total mixed powder of the composition.

[0117] Step S7, compressing the total mixed powder into tablets according to a preset weight, wherein the preset weight is 0.49 g / tablet, and the weight difference limit requirement is ±5%.

[0118] Step S8, coating the tableted composition.

[0119] Comparative Example 3

[0120] A composition comprises the following raw materials in parts by weight: 10 parts of pomegranate powder, 16 parts of galangal, 2.5 parts of nutmeg, 2.5 parts of cinnamon, 24 parts of calcium lactate, 38 parts of sorbitol and 2 parts of magnesium stearate.

[0121] The preparation method of the composition comprises the following steps:

[0122] Step S1, weighing pomegranate powder, galangal, nutmeg, cinnamon, calcium lactate, sorbitol and magnesium stearate according to weight.

[0123] Step S2: Grind the weighed galangal, nutmeg and cinnamon to obtain a powder, wherein the particle size of the powder is between 100 meshes and 150 meshes.

[0124] Step S3: mixing the powder with pomegranate powder, calcium lactate and sorbitol to obtain a premixed powder.

[0125] Step S4: adding a binder to the premixed powder to prepare uniform wet granules.

[0126] Step S5: Drying the wet granules to obtain dry premix granules.

[0127] Step S6: mixing the premix granules with magnesium stearate for 18-22 minutes to obtain a total mixed powder of the composition.

[0128] Step S7, compressing the total mixed powder into tablets according to a preset weight, wherein the preset weight is 0.49 g / tablet, and the weight difference limit is required to be ±5%.

[0129] Step S8, coating the tableted composition.

[0130] Comparative Example 4

[0131] A composition comprises the following raw materials in parts by weight: 10 parts of pomegranate powder, 16 parts of galangal, 5 parts of black pepper, 2.5 parts of cinnamon, 24 parts of calcium lactate, 38 parts of sorbitol and 2 parts of magnesium stearate.

[0132] The preparation method of the composition comprises the following steps:

[0133] Step S1, weighing pomegranate powder, galangal, black pepper, cinnamon, calcium lactate, sorbitol and magnesium stearate according to weight.

[0134] Step S2: Grind the weighed galangal, black pepper and cinnamon to obtain a powder, wherein the particle size of the powder is between 100 meshes and 150 meshes.

[0135] Step S3: mixing the powder with pomegranate powder, calcium lactate and sorbitol to obtain a premixed powder.

[0136] Step S4: adding a binder to the premixed powder to prepare uniform wet granules.

[0137] Step S5: Drying the wet granules to obtain dry premix granules.

[0138] Step S6: mixing the premix granules with magnesium stearate for 18-22 minutes to obtain a total mixed powder of the composition.

[0139] Step S7, compressing the total mixed powder into tablets according to a preset weight, wherein the preset weight is 0.49 g / tablet, and the weight difference limit requirement is ±5%.

[0140] Step S8, coating the tableted composition.

[0141] The following experiments were conducted on the compositions for relieving stomach cold pain prepared in Examples 1 to 5, and Comparative Examples 1 to 4 and conventional Chinese medicine formulas for relieving stomach cold pain.

[0142] The experimental population consisted of 200 patients whose clinical symptoms were stomach cold and stomach pain; the patients were randomly assigned to experimental groups, with 20 people in each group.

[0143] Dosage: Take the composition in each example and comparative example for 7 days.

[0144] The observation indicators are: symptom assessment, recording the subjective feelings of the experimental population before and after taking the medicine, such as pain relief, stomach-strengthening and cold-relieving, taste, and analyzing the changes in symptoms and the proportion of improvement.

[0145] Among them, based on the indicators of pain relief, stomach invigorating and cold dispelling, and mouthfeel of conventional Chinese medicine formulas for stomach cold pain, the experimental data of each embodiment and each comparative example are shown in the following table:

[0146]

[0147] As can be seen from the above table, the composition for relieving stomach cold pain of the present invention has obvious analgesic and stomach-strengthening and cold-removing effects, and embodiment 1 is the best embodiment. In addition, the above table can also clearly show that the composition for relieving stomach cold pain, which includes pomegranate powder, galangal, black pepper, nutmeg, cinnamon, calcium lactate, sorbitol and magnesium stearate, can play a good effect of stomach-strengthening and cold-removing and stomach-warming and nourishing by the synergistic cooperation of each component, and can also well relieve stomach cold pain, thereby being beneficial to regulating the body functions of patients with stomach cold pain.

[0148] At the same time, this embodiment also relates to an application of the above composition in the preparation of food for improving chills and pain, functional food, health care product, special diet and medicine.

[0149] In the present invention, by applying the above-mentioned composition to the preparation of food, functional food, health product, special diet or medicine for improving chills and pain, the related food or medicine having the composition has the effects of strengthening the stomach and removing cold, warming the stomach and nourishing the stomach, can well relieve stomach pain, and is beneficial to regulating the body functions of patients with stomach pain.

[0150] The above description is only a preferred embodiment of the present invention and is not intended to limit the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims

1. A composition for relieving stomach cold pain, characterized in that: The raw materials for preparing the composition include pomegranate powder, galangal, black pepper, nutmeg, cinnamon, calcium lactate, sorbitol and magnesium stearate.

2. The composition for relieving stomach cold pain according to claim 1, characterized in that The weight parts of each of the preparation raw materials are respectively: 5-15 parts of pomegranate powder, 10-21 parts of galangal, 2-7 parts of black pepper, 1-6 parts of nutmeg, 1-6 parts of cinnamon, 20-30 parts of calcium lactate, 34-45 parts of sorbitol and 0.5-3 parts of magnesium stearate.

3. The composition for relieving stomach cold pain according to claim 2, characterized in that: The weight parts of each of the preparation raw materials are respectively: 6-14 parts of pomegranate powder, 11-20 parts of galangal, 3-6 parts of black pepper, 2-5 parts of nutmeg, 2-5 parts of cinnamon, 21-29 parts of calcium lactate, 35-44 parts of sorbitol and 1-2.5 parts of magnesium stearate.

4. The composition for relieving stomach cold pain according to claim 2, characterized in that The weight parts of each of the preparation raw materials are respectively: 7-13 parts of pomegranate powder, 12-19 parts of galangal, 4-5 parts of black pepper, 3-4 parts of nutmeg, 3-4 parts of cinnamon, 22-28 parts of calcium lactate, 36-43 parts of sorbitol and 1-2.5 parts of magnesium stearate.

5. A method for preparing a composition for relieving stomach cold pain, characterized in that: The preparation method comprises: Weigh pomegranate powder, galangal, black pepper, nutmeg, cinnamon, calcium lactate, sorbitol and magnesium stearate according to weight; Grinding the weighed galangal, black pepper, nutmeg and cinnamon to obtain a powder; The powder is mixed with pomegranate powder, calcium lactate and sorbitol to obtain a premixed powder; adding a binder to the premixed powder to prepare uniform wet granules; drying the wet granules to obtain dry premix granules; The premix granules are mixed with magnesium stearate to obtain a total mixed powder of the composition.

6. The method for preparing the composition for relieving stomach cold pain according to claim 5, characterized in that: Includes at least one of the following features: (a) the particle size of the powder is between 100 mesh and 150 mesh; (b) the adhesive is 95% ethanol; (c) The moisture content of the premix particles is not more than 7.5%.

7. The method for preparing the composition for relieving stomach cold pain according to claim 5, characterized in that: The step of crushing the weighed raw materials to obtain powder comprises: crushing the weighed raw materials for multiple times, and sieving the crushed raw materials after each crushing.

8. The method for preparing the composition for relieving stomach cold pain according to claim 5, characterized in that: The preparation method further comprises: The total mixed powder is tableted according to a preset weight, and the tableted composition is coated.

9. The method for preparing the composition for relieving stomach cold pain according to claim 8, characterized in that: The preset weight is 0.49 g / tablet, and the weight difference limit is required to be ±5%.

10. The use of the composition for relieving stomach cold pain according to any one of claims 1 to 4, characterized in that: The composition for relieving stomach cold pain is used for preparing food for improving chill pain, functional food, health care product, special diet or medicine.

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