Traditional Chinese medicine composition for ear ironing operation as well as preparation method and application of traditional Chinese medicine composition

Abstract

The invention discloses a traditional Chinese medicine composition for ear ironing as well as a preparation method and application thereof, belongs to the technical field of medicines for ear ironing, and solves the technical problem that related matched medicines for enhancing the effects of dredging collaterals, activating blood and the like are lacked in the current ear ironing. According to the technical scheme, the traditional Chinese medicine composition for the ear ironing operation is prepared from the following traditional Chinese medicinal materials in parts by weight: 16-20 parts of angelica sinensis, 8-12 parts of ligusticum wallichii, 8-12 parts of radix curcumae, 12-18 parts of cowherb seeds, 12-18 parts of rhizoma drynariae, 12-18 parts of loose knots and 12-18 parts of motherwort fruits. The medicine has the advantages of simple components, good curative effect, small side effect and the like.

Description

Technical Field

[0001] The invention relates to the technical field of medicines for ear ironing, and in particular to a traditional Chinese medicine composition for ear ironing, a preparation method and application thereof. Background Art

[0002] Ear ironing is ear massage, which has a long history. The Song Dynasty's "Su Shen Liang Fang" records: "Rub the ears and eyes to help the true qi." In the "Eastern Medicine Treasure Mirror" written by Xu Jun of Korea during the Wanli period of the Ming Dynasty, it is recorded: "Rub the ear rim with your hands, no matter how many times, it is said to repair the city walls, to replenish the kidney qi, and to prevent deafness." Modern ear acupuncture theory suggests that all tissues and organs of the whole body have projection points on the auricle, and massaging the auricle has the function of regulating the functions of the organs and tissues of the whole body. The Song Dynasty's "Su Shen Liang Fang" records: "Rub the ears and eyes to help the true qi. The "Fuxing Jue" recipe for saving the five internal organs from sudden death: Borax drops to the eyes to clear the liver qi; soap bean blows the nose to clear the lung qi; saltpeter and realgar are applied to the tongue to clear the heart qi; melon stems open the throat to clear the spleen qi; onions are pressed on the ears to clear the kidney qi."

[0003] "The whole body's energy runs through the ears." There are many acupoints on the small ears that are connected to the meridians of the whole body. Apply gentle and correct massage to the ears. You can use rubbing, wiping, lifting, pressing, pinching, twisting, etc. The intensity should be appropriate. As long as you persist in it for a long time, it can not only regulate qi and blood, but also prevent diseases, health care, and beauty.

[0004] Massaging different acupuncture points on the ear can play a certain role in disease prevention, health care and beauty. If it can be combined with medicines with certain functions, the therapeutic effect can be enhanced.

[0005] However, there is a lack of research on traditional Chinese medicines used for ear ironing, which has prevented the ear ironing technique from developing further. Summary of the invention

[0006] The invention provides a Chinese medicine composition for ear ironing, a preparation method and an application thereof, so as to solve the technical problem that the current ear ironing lacks relevant matching drugs to enhance the effects of promoting qi, activating blood circulation and relieving constipation.

[0007] The technical solution adopted by the present invention is as follows:

[0008] A traditional Chinese medicine composition for ear ironing is prepared from the following traditional Chinese medicines in parts by weight: 16-20 parts of angelica sinensis, 8-12 parts of chuanxiong, 8-12 parts of curcuma, 12-18 parts of fenugreek, 12-18 parts of drynaria, 12-18 parts of pine knotweed, and 12-18 parts of clematis nitidissima.

[0009] The present invention preferably adopts a Chinese medicine composition for ear ironing, which is prepared from the following Chinese medicinal materials by weight: 20 parts of angelica sinensis, 10 parts of chuanxiong, 10 parts of curcuma, 15 parts of fenugreek, 15 parts of drynaria, 15 parts of pine knot, and 15 parts of cuneiformis.

[0010] The present invention preferably adopts a Chinese medicine composition for ear ironing, which is prepared by the following Chinese medicinal materials by weight: 20g of angelica sinensis, 10g of chuanxiong, 10g of curcuma, 15g of fenugreek, 15g of drynaria, 15g of pine knot, and 15g of cuneiformis.

[0011] The six Chinese medicinal materials of the present invention are combined according to the following compatibility principle: angelica is the main drug, chuanxiong, curcuma, fenugreek and cuneizi are the assistant drugs, drynaria is the adjuvant drug, and turpentine is the guiding drug.

[0012] Among them, Angelica sinensis is the main medicine that is good at nourishing blood, activating blood circulation, moistening intestines and relieving constipation. It tastes sweet and heavy, and is specifically used to nourish blood. Its aroma is light and pungent, and it can promote blood circulation. It has both nourishing and moving, and promoting circulation. It is truly a qi medicine in the blood, so it can nourish the body and blood, nourish qi and produce essence, calm the five internal organs, and relieve constipation and pain. Chuanxiong is pungent and warm, and can promote qi and blood circulation and relieve constipation. The dosage is 10 parts. Curcuma can promote blood circulation and relieve pain, and the taste is cool. While helping Angelica to promote blood circulation, it can also clear the heat caused by blood stasis. Vaccaria and Cnidium monnieri, both medicines enter the liver meridian, soothe the liver and regulate qi, and when qi flows, blood will flow. The total dosage of the four is 50 parts, which are all ministers. Drynaria can nourish the liver and kidney, promote blood circulation and relieve pain, so as to prevent blood stasis from accumulating in the liver and kidney over a long period of time. The dosage is 15 parts, which is an adjuvant. Turpentine can reduce swelling and relieve pain, dredge the meridians and promote blood circulation, and at the same time can lead other medicines into the meridians. The dosage is 15 parts, which is a guiding medicine. Various medicines are combined with ear ironing to achieve the effect of promoting qi and blood circulation and relieving constipation.

[0013] The present invention preferably provides a Chinese medicine composition for ear ironing, wherein the Chinese medicine composition is in the form of a powder.

[0014] A method for preparing a Chinese medicine composition for ear ironing comprises the following steps:

[0015] Step 1: Weigh the above Chinese medicinal materials;

[0016] Step 2: Grind the above medicinal materials into fine powder;

[0017] Step 3: Wrap it in a non-woven bag, heat it in the microwave, and place it in the ear iron for use;

[0018] The microwave oven heating temperature is 55-65°C.

[0019] A method for preparing a Chinese medicine composition for ear ironing, wherein in step 2, the above-mentioned medicinal materials are beaten into fine powder.

[0020] An application of a Chinese medicine composition for ear ironing, wherein the Chinese medicine composition is combined with ear ironing to promote qi, activate blood circulation and relieve constipation.

[0021] Preferably, the applications include slow-transmission constipation, functional outlet obstruction constipation and mixed constipation.

[0022] In summary, compared with the prior art, the present invention has the following advantages and beneficial effects:

[0023] 1. The Chinese medicine composition for promoting qi and blood circulation and relieving constipation of the present invention is compatible with the principle of "monarch, minister, assistant and envoy" of Chinese medicine, has a small number of medicinal flavors, only 7 medicinal flavors, and has the advantages of high efficacy, no toxic side effects, low cost, etc. The raw materials selected by the present invention and their ratios have been screened through experiments and have the advantage of significant effects.

[0024] 2. The preparation method of the present invention is simple and easy to implement, and is easily accepted by patients. It is a safe and effective Chinese medicine composition for treating functional constipation, and has a good application prospect. The present invention can effectively improve the constipation symptoms, TCM syndromes and quality of life of functional constipation (intestinal heat syndrome), is safe for short-term application, and has low adverse reactions. DETAILED DESCRIPTION

[0025] In order to make the purpose, technical solutions and advantages of the present invention more clearly understood, the present invention is further described in detail below in conjunction with embodiments. The illustrative embodiments of the present invention and their description are only used to explain the present invention and are not intended to limit the present invention.

[0026] Example 1

[0027] A Chinese medicine composition for ear ironing is prepared from the following Chinese medicinal materials by weight: 16g of angelica sinensis, 8g of chuanxiong, 12g of curcuma, 18g of fenugreek, 12g of drynaria, 12g of pine knot, and 18g of cuneiformis.

[0028] A Chinese medicine composition for ear ironing is prepared by the following method:

[0029] Step 1: Weigh the above Chinese medicinal materials;

[0030] Step 2: Grind the above herbs into fine powder.

[0031] Step 3: Wrap it in a special bag, heat it in the microwave and place it in the ear iron for use.

[0032] Example 2

[0033] The difference between this embodiment and embodiment 1 is that the dosage of each Chinese medicinal material is different, as follows:

[0034] Angelica 20g, Chuanxiong 10g, Curcuma 10g, Vaccaria 15g, Drynaria 15g, Turmeric 15g, Cnidium monnieri 15g.

[0035] Example 3

[0036] The difference between this embodiment and embodiment 1 is that the dosage of each Chinese medicinal material is different, as follows:

[0037] Angelica 20g, Chuanxiong 12g, Curcuma 8g, Vaccaria 12g, Drynaria 18g, Turmeric 18g, Cnidium monnieri 12g.

[0038] Clinical Trials

[0039] 1. Information

[0040] 1.1 General Information

[0041] The cases were patients with constipation admitted to the Endocrinology Department of Chongqing Traditional Chinese Medicine Hospital from June 2023 to March 2024. A simple random number table method was used to randomly divide 80 subjects into two groups, the experimental group and the control group, with 40 cases in each group.

[0042] 1.2 Inclusion criteria

[0043] ① Meet the Rome IV diagnostic criteria for functional constipation; ② Age ≥ 18 years old, regardless of gender; ③ Have undergone colonoscopy within one year and no obvious abnormalities were found; ④ Have not taken central nervous system inhibitory drugs or drugs that affect gastrointestinal motility for 1 week or currently; ⑤ Have no damage or scars on the ear skin; ⑥ The patient is conscious, voluntarily participates and signs the informed consent form.

[0044] 1.3 Exclusion criteria

[0045] ① Patients with severe constipation or those with surgical indications; ② Patients with coagulation dysfunction; ③ Patients with serious primary diseases, such as cardiovascular, cerebrovascular, liver, kidney and hematopoietic system diseases; ④ Patients with mental illnesses.

[0046] 2. Treatment Methods

[0047] 2.1 Control group

[0048] Give Biantong Capsules (0.35g*27 capsules, national medicine standard Z19990071, manufacturer: Jianmin Pharmaceutical Group Co., Ltd.), usage: 3 capsules at a time, twice a day, as well as routine care such as psychology, diet, and exercise.

[0049] 2.2 Experimental Group

[0050] On the basis of routine care and basic treatment, ear ironing was given, 30 minutes each time for both ears, once a day. The drug used for ear ironing was the drug in Example 2, wherein the dosage of the drug was 30 g each time.

[0051] 3. Observation time

[0052] The treatment lasted for 3 weeks. The gastrointestinal symptom scores and stool characteristics scores of the two groups of patients were evaluated before and after treatment.

[0053] 4. Observation indicators

[0054] 4.1 General data indicators

[0055] The subjects' age, gender, duration of constipation, etc.

[0056] 4.2 Main efficacy indicators

[0057] 4.2.1 Gastrointestinal symptom score

[0058] The Chinese version of PAC-SYM was used to evaluate constipation symptoms in the two groups. The scale includes three dimensions, namely stool characteristics, rectal symptoms and abdominal symptoms, with a total of 12 items. The Likert 5-point scoring method was used, and the total score of the scale was the sum of the scores of each item.

[0059] 4.2.2 Bristol stool characteristics score

[0060] The stool characteristics were scored according to the Bristol stool characteristics classification, with type I scoring 1 point and type II scoring 2 points, and so on. The subjects or their family members were asked to score and record each spontaneous bowel movement on the day according to the Bristol stool characteristics classification chart. The stool characteristics score was the sum of the corresponding Bristol classification scores for each spontaneous bowel movement in the previous week divided by the total number of spontaneous bowel movements in the week.

[0061] 4.2.3 Efficacy evaluation

[0062] (1) Basically cured: defecation once within 2 days, smooth defecation, and complete disappearance of clinical symptoms;

[0063] (2) Significantly effective: defecation within 3 days, poor defecation, and significant improvement in symptoms and signs, but not complete recovery;

[0064] (3) Effective: The interval between bowel movements is shortened by more than 1 day, and symptoms and signs are improved;

[0065] (4) Ineffective: Constipation symptoms do not improve or may even worsen.

[0066] 5. Results

[0067] 5.1 General Information

[0068] The general information of the two groups of patients is shown in Table 1. There was no statistically significant difference between the two groups (P>0.05).

[0069] Table 1 Comparison of general information of patients in the two groups

[0070]

[0071] 5.2 Comparison of gastrointestinal symptom scores between the two groups

[0072] Before treatment, there was no significant difference in gastrointestinal symptom scores between the two groups (P>0.05), which was comparable. After treatment, the score of the experimental group was significantly lower than that of the control group (P<0.05), and the effect of the experimental group was better than that of the control group. See Table 2 for details.

[0073] Table 2 Gastrointestinal symptom scores of the two groups

[0074]

[0075] Note: **P<0.01 before and after treatment in this group. ★ Comparison among groups after treatment, P<0.05.

[0076] 5.3 Comparison of stool characteristics scores between the two groups

[0077] Before treatment, there was no significant difference in BSFS scores between the two groups (P>0.05), which was comparable. After treatment, the score of the experimental group was significantly lower than that of the control group (P<0.05), and the effect of the experimental group was better than that of the control group. See Table 3 for details.

[0078] Table 3 Bristol stool characteristics scale (BSFS) scores of the two groups

[0079]

[0080] Note: **P<0.01 before and after treatment in this group. ★ After treatment, the intergroup comparison was P<0.05

[0081] 5.4 Comparison of Effectiveness

[0082] The effective rate of the experimental group was higher than that of the control group (P<0.05), see Table 4.

[0083] Table 4 Comparison of clinical efficacy between the two groups

[0084]

[0085] On the basis of the aforementioned three-week treatment, the treatment was extended for one more week, that is, after four weeks of treatment, the effectiveness was compared, as shown in the following Table 5.

[0086] Table 5 Comparison of clinical efficacy between the two groups of patients after one week of treatment

[0087]

[0088] It can be seen from Table 5 that the drugs and treatment regimens of the present invention showed better and faster efficacy in the process of extending the treatment cycle compared with the control group.

[0089] From the above comparison of therapeutic effects, it can be seen that the Chinese medicine composition of the present invention can significantly improve constipation when used in ear ironing, and because it is not taken orally, the side effects caused by the drug are reduced to a certain extent.

[0090] The specific implementation methods described above further illustrate the objectives, technical solutions and beneficial effects of the present invention in detail. It should be understood that the above description is only a specific implementation method of the present invention and is not intended to limit the scope of protection of the present invention. Any modifications, equivalent substitutions, improvements, etc. made within the spirit and principles of the present invention should be included in the scope of protection of the present invention.

Claims

1. A Chinese medicine composition for ear ironing, characterized in that: The invention is prepared from the following Chinese medicinal materials by weight: 16-20 parts of angelica sinensis, 8-12 parts of chuanxiong, 8-12 parts of turmeric, 12-18 parts of fenugreek, 12-18 parts of drynaria, 12-18 parts of pine knotweed, and 12-18 parts of clematis nitidissima.

2. A Chinese medicine composition for ear ironing according to claim 1, characterized in that: The invention is made of the following Chinese medicinal materials by weight: 20 parts of angelica sinensis, 10 parts of chuanxiong, 10 parts of curcuma, 15 parts of fenugreek, 15 parts of drynaria, 15 parts of pine knot, and 15 parts of cuneiformis.

3. A Chinese medicine composition for ear ironing according to claim 1 or 2, characterized in that: One dose of medicine is made of the following Chinese medicinal materials by weight: 20g of Angelica sinensis, 10g of Ligusticum chuanxiong, 10g of Curcuma aromatica, 15g of Vaccaria segetalis, 15g of Drynaria fortunei, 15g of Turpentine knotweed, and 15g of Cnidium monnieri.

4. A Chinese medicine composition for ear ironing according to claim 1 or 2, characterized in that: The dosage form of the Chinese medicine composition is powder.

5. A method for preparing a Chinese medicine composition for ear ironing, characterized in that: The steps include: Step 1: Weigh the Chinese medicinal material as described in any one of claims 1 to 3; Step 2: Grind the above medicinal materials into fine powder; Step 3: Wrap it in a special non-woven bag, heat it and place it in the ear iron for use.

6. The method for preparing a Chinese medicine powder for ear ironing according to claim 5, characterized in that: In the step 3, the heating is carried out by microwave heating, and the temperature of the microwave heating is 55-65°C.

7. An application of a Chinese medicine composition for ear ironing, characterized in that: The Chinese medicine composition is combined with ear ironing technique to promote qi and blood circulation and relieve constipation.

8. The use of a Chinese medicine composition for ear ironing according to claim 7, characterized in that: The applications include slow-transmission constipation, functional outlet obstruction constipation and mixed constipation.

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