Transcranial electrical stimulator and stimulation current adjusting method thereof

Abstract

The invention discloses a transcranial electrical stimulator and a stimulation current adjusting method thereof in the technical field of electrical stimulators, the transcranial electrical stimulator comprises an electrode cap sleeved on the cranium, the electrode cap is provided with an electrode in contact with the cranium, the electrode is electrically connected with the transcranial electrical stimulator, and the electrode cap is connected with the electrode. The cranial electrical stimulator is electrically connected with the cranial electrical control mechanism, and the cranial electrical stimulator and / or the cranial electrical control mechanism are / is connected with the power supply; the electrode cap is used for fixing the electrode and is stably worn on the cranium; the electrode is used for electrically contacting with the cranium and providing electrical stimulation for the cranium; the cranial electrical stimulator is used for generating and outputting stimulation current; and the cranial electrical control mechanism is used for adjusting parameters of the stimulation current output by the cranial electrical stimulator. According to the transcranial electrical stimulator comfortable to wear and flexible to use and the stimulation current adjusting method thereof, the stimulation current output parameters can be adjusted according to actual use requirements, and the use performance and the use compatibility are optimized.

Description

Technical Field

[0001] The present invention relates to the technical field of electrical stimulators, and in particular to a transcranial electrical stimulator and a stimulation current regulation method thereof. Background Art

[0002] The background technology of the multi-channel transcranial electrical stimulation sleep analyzer is transcranial electrical stimulation (tES), which is based on the understanding of brain function and neural plasticity. Neuroplasticity refers to the ability of the brain to adapt to changes in experience and environment through changes in structure and function. Transcranial electrical stimulation technology uses this plasticity to non-invasively apply electrical stimulation to the brain to regulate the excitability of neurons and the function of neural networks.

[0003] The multi-channel transcranial electrical stimulation sleep analyzer is a neuromodulator with the characteristics of portability, non-destructiveness, low cost, safety, and long-term effectiveness. It consists of an electrical stimulator, a positive electrode and a negative electrode. The electrodes are fixed to the scalp. The stimulator can output a weak current of 0-2 mA, so that the current flows from the positive electrode to the negative electrode and forms a loop. Part of the current passes through the skull and acts on the cerebral cortex, which can change the potential of neurons, regulate the excitability of neurons and the secretion of related neurotransmitters, and then affect the corresponding perception, movement and cognitive behavior.

[0004] The device is also used to help patients with abnormal brain functions such as depression, anxiety, and stroke. Later studies on healthy adults showed that transcranial electrical stimulation technology can also improve cognitive abilities in multiple tasks, such as language ability, mathematical ability, attention, memory, coordination ability, and problem-solving ability. Therefore, it has been widely used in clinical treatment and brain science research in recent years.

[0005] Background technology includes the following aspects: Neurophysiological basis: Transcranial electrical stimulation technology is based on the electrophysiological properties of brain neurons, that is, neurons will fire action potentials when they receive sufficient stimulation. Communication between neurons relies on electrochemical signals, and transcranial electrical stimulation modulates these signals by applying external current.

[0006] Localized functions of the cerebral cortex: Different areas of the cerebral cortex are responsible for different functions, such as movement, sensation, language, etc. Transcranial electrical stimulation can target these functional areas by placing electrodes at specific locations in the cerebral cortex.

[0007] Influence of electrical stimulation parameters: Parameters such as current intensity, duration, frequency and waveform will affect the effect of stimulation.

[0008] The researchers experimentally determined the effects of different parameters on brain activity and how these parameters could be optimized to achieve the desired therapeutic effect.

[0009] Development of non-invasive brain stimulation technology: Transcranial electrical stimulation is one of many non-invasive brain stimulation technologies, other technologies include transcranial magnetic stimulation (TMS), deep brain stimulation (DBS), etc. The development of these technologies provides new tools for studying brain function and treating neuropsychiatric diseases.

[0010] Progress in clinical applications and research: Transcranial electrical stimulation has been used to treat a variety of diseases, such as depression, anxiety, chronic pain, motor dysfunction, etc. Researchers are also exploring its potential in cognitive enhancement, learning disabilities, rehabilitation therapy, etc.

[0011] Safety and ethical considerations: Transcranial electrical stimulation is considered a relatively safe brain stimulation technology, but the side effects and long-term effects of stimulation still need to be considered. The background technology of transcranial electrical stimulators is the result of multidisciplinary cross-disciplinary research, involving fields such as neuroscience, biomedical engineering, psychology, and clinical medicine. With the deepening of our understanding of the brain and the advancement of technology, the application and research of transcranial electrical stimulators will continue to expand, bringing more benefits to human health.

[0012] Defects and shortcomings of the existing technology: Although the existing transcranial electrical stimulation (tES) technology provides a non-invasive means for neuroscience research and clinical treatment, it still has some defects and shortcomings in practical applications, mainly including: 1. Unclear mechanism of action: Although transcranial electrical stimulation has been widely used in the treatment of various neuropsychiatric diseases, its specific mechanism of action is not yet fully understood, which limits the in-depth understanding and optimization of its effects.

[0013] 2. Standardization of stimulation parameters: The effect of transcranial electrical stimulation is affected by multiple parameters, such as current intensity, frequency, duration, etc. At present, the setting of these parameters has not been standardized, and there may be differences between different studies, affecting the reliability and reproducibility of the results.

[0014] 3. Individual differences: Different individuals may have significant differences in their responses to transcranial electrical stimulation, which may be related to factors such as genetic background, brain structure, physiological state, etc. At present, there is still a lack of effective individualized treatment plans.

[0015] 4. Long-term effects and safety: The long-term effects and safety of transcranial electrical stimulation still need further study. Long-term use may lead to potential side effects such as headaches, skin irritation, cognitive changes, etc.

[0016] 5. Stimulation targeting: The non-invasive nature of transcranial electrical stimulation limits its spatial resolution. The current is difficult to accurately target specific brain areas and may affect non-target areas.

[0017] 6. Equipment and technical limitations: Currently available transcranial electrical stimulation devices still have room for improvement in terms of portability, ease of operation, and user-friendliness. Technical limitations also affect the accuracy and efficiency of stimulation. Summary of the invention

[0018] The present invention overcomes the shortcomings of the prior art and provides a transcranial electrical stimulator that is comfortable to wear and flexible to use and a stimulation current adjustment method thereof, which can adjust the stimulation current output parameters according to actual usage requirements and optimize usage performance and usage compatibility.

[0019] To achieve the above-mentioned purpose, the technical solution adopted by the present invention is: a transcranial electrical stimulator, comprising: an electrode cap mounted on the skull, the electrode cap is provided with electrodes in contact with the skull, the electrodes are electrically connected to a cranial electrical stimulator, the cranial electrical stimulator is electrically connected to a cranial electrical control mechanism, the cranial electrical stimulator and / or the cranial electrical control mechanism are connected to a power supply; the electrode cap is used to fix the electrodes and to be worn on the skull; the electrodes are used to electrically contact the skull and provide electrical stimulation to the skull; the cranial electrical stimulator is used to generate and output stimulation current; the cranial electrical control mechanism is used to adjust the parameters of the stimulation current output by the cranial electrical stimulator.

[0020] In a preferred embodiment of the present invention, the electrode comprises a metal piece connected to a stimulation current output terminal of the cranial electrical stimulator; Conductive rubber is arranged on the metal piece; or, a plant fiber layer soaked in salt water is arranged on the metal piece; or, conductive rubber and a plant fiber layer soaked in salt water are arranged on the metal piece; And / or, the cranial electrical stimulator is a multi-channel electrode transcranial electrical stimulation analyzer.

[0021] In a preferred embodiment of the present invention, the electrode cap is a saline electrode cap, which includes an elastic cap body with an electrode positioning hole on the cap body; the electrode is a saline electrode; the saline electrode includes an electrode base and an electrode head, the electrode base is arranged at the electrode positioning hole on the cap body, a socket is arranged in the middle of the electrode base, a metal piece is passed through the socket, a saline-soaked plant fiber layer connected to the metal piece is attached to the cap body, and the saline-soaked plant fiber layer is in contact with the scalp of the skull.

[0022] In a preferred embodiment of the present invention, the parameters of the stimulation current include current intensity, frequency, and duration; and / or the stimulation waveform output by the electrode is one or more of direct current, sine wave, sawtooth wave, and pulse wave.

[0023] In a preferred embodiment of the present invention, the cranial electrostatic control mechanism includes a cranial electrostatic control circuit connected to the cranial electrostatic stimulator and the electrode, and the cranial electrostatic control circuit includes: a cranial electrostatic control chip, a crystal oscillator pin of the cranial electrostatic control chip is also connected to a crystal oscillator circuit, ADC pins of the cranial electrostatic control chip are respectively grounded through capacitors, a DAC pin of the cranial electrostatic control chip is connected to an input end of a voltage follower isolation circuit, an output end of the voltage follower isolation circuit is connected to an input end of a constant current source circuit, a switch pin of the cranial electrostatic control chip is connected to a switch circuit, and an internal power supply pin of the cranial electrostatic control chip is connected to a VDD chip power supply module; It also includes a program burning interface circuit, a reference power supply circuit, and an LCD interface circuit connected to the cranial electromechanical control chip.

[0024] In a preferred embodiment of the present invention, the VDD chip power module comprises: a VDD power chip, a VDD pin of the VDD power chip is connected to a VCC power supply at a common point, a VBAT pin of the VDD power chip is connected to the VCC power supply at one point, and another is grounded through a capacitor C5, a VDDA pin of the VDD power chip is connected to the VCC power supply at one point through a resistor R11, and another is connected to a reference power supply REF3.3V through a resistor R89, and a VSS pin and a VSSA pin of the VDD power chip are grounded at a common point; And / or, the switch circuit includes: a switch SW1, one end of the switch SW1 is connected to the NRAT pin of the cranial electroencephalography control chip, the other end of the switch SW1 is grounded, and a capacitor C6 is connected in parallel to both ends of the switch SW1, and the NRAT pin is connected to the VCC power supply through a resistor R12; And / or, the crystal oscillator circuit includes a resistor R10 and a crystal oscillator X1 connected in parallel to a pair of crystal oscillator pins, and two ends of the crystal oscillator X1 are grounded through capacitors C3 and C4 respectively; And / or, the program burning interface circuit includes: an interface connector 1, pins 5 and 6 of the interface connector 1 are grounded at a common point; pin 1 of the interface connector 1 is grounded; pin 2 of the interface connector 1 is connected to two paths, one path is connected to the VCC power supply, and the other path is grounded through a capacitor C27; pin 3 of the interface connector 1 is connected to the VCC power supply through a resistor R6 as an SLK terminal, and pin 4 of the interface connector 1 is connected to the VCC power supply through a resistor R5 as a DIO terminal; And / or, the reference power supply circuit includes: a voltage reference chip, the IN terminal of the voltage reference chip leads to two paths, one path is connected to the VCC power supply, and the other path is grounded through a capacitor C97, the OUT terminal of the voltage reference chip leads to two paths, one path leads to the reference power supply REF3.3V, and the other path is grounded through a parallel capacitor C98 and a capacitor C106; the GND terminal of the voltage reference chip is grounded; And / or, the LCD interface circuit includes: interface connector 2, pins 5 and 6 of the interface connector 2 are grounded at a common point; pin 1 of the interface connector 2 is grounded; pin 2 of the interface connector 2 is connected to the U1_TXD pin of the cranial electric control chip; pin 3 of the interface connector 2 is connected to the U1_RXD pin of the cranial electric control chip, and pin 4 of the interface connector 2 is connected to the VCC power supply; And / or, the voltage follower isolation circuit includes: an operational amplifier chip, the OUTA pin of the operational amplifier chip is connected to the -INA pin; the +INA pin of the operational amplifier chip is connected to the DAC_IN2 pin of the cranial electrostatic control chip, and the V- pin of the operational amplifier chip is grounded; the V+ pin of the operational amplifier chip leads to two paths, one is connected to the VCC power supply, and the other is grounded through capacitor C107; the OUTB pin of the operational amplifier chip is connected to the -INB pin, and is connected to the DAC_OUT1 pin of the impedance operational amplifier chip in the constant current source circuit; the +INB pin of the operational amplifier chip is connected to the DAC_IN1 pin of the cranial electrostatic control chip.

[0025] In a preferred embodiment of the present invention, the cranial electrical stimulator includes a constant current source circuit electrically connected to the cranial electrical control circuit, and the constant current source circuit includes an input voltage source and a plurality of groups of impedance converters electrically connected to the input voltage source; Each impedance converter includes: an impedance operational amplifier chip, the +INA pin of the impedance operational amplifier chip is connected to the OUTB pin of the operational amplifier chip of the voltage follower isolation circuit through a resistor R56, the +INA pin of the impedance operational amplifier chip is connected to the OB2 node through a resistor R60, the -INA pin of the impedance operational amplifier chip is connected to the electrode as the LMOUT terminal output stimulation current through a resistor R55, the OUTA pin of the impedance operational amplifier chip is connected to the -INA pin of the impedance operational amplifier chip through a resistor R59, and the two ends of the resistor R59 are connected in parallel with a capacitor C83, and the connection node of capacitor C83 and resistor R59 leads to IB2 node through resistor R62, the V- pin of the impedance operational amplifier chip is grounded through capacitor C68, and the V- pin of the impedance operational amplifier chip is also connected to the power supply -25V of the input voltage source; the V+ pin of the impedance operational amplifier chip is grounded through capacitor C67, and the V+ pin of the impedance operational amplifier chip is connected to the power supply +25V of the input voltage source, the OUTB pin and -INB pin of the impedance operational amplifier chip are connected to the OB2 node at a common point, and the +INB pin of the impedance operational amplifier chip is connected to the IB2 node.

[0026] In a preferred embodiment of the present invention, the cranial electrical stimulator includes an impedance detection circuit electrically connected to the cranial electrical control circuit, and the impedance detection circuit includes: an impedance detection operational amplifier chip, the +INA pin of the impedance detection operational amplifier chip is connected to the IB2 node through a resistor R69, the -INA pin of the impedance detection operational amplifier chip is connected to the OUTA pin of the impedance detection operational amplifier chip, the OUTA pin of the impedance detection operational amplifier chip is also connected to the +INB pin of the impedance detection operational amplifier chip through a resistor R71, the V- pin of the impedance detection operational amplifier chip is grounded through a capacitor C71, and the V+ pin of the impedance detection operational amplifier chip is connected to the ground. It is connected to the power supply +25V of the input voltage source, and the V+ pin of the impedance detection operational amplifier chip is also grounded through capacitor C72, the OUTB pin of the impedance detection operational amplifier chip is connected to the ADC pin of the cranial electrostatic control chip, the ADC pin of the cranial electrostatic control chip is also grounded through a voltage regulator diode D9, and the OUTB pin of the impedance detection operational amplifier chip is also connected to the -INB pin of the impedance detection operational amplifier chip through resistors R72 and R80, the -INB pin of the impedance detection operational amplifier chip is also grounded through resistor R73, and the +INB pin of the impedance detection operational amplifier chip is connected to the reference power supply REF1.2V through resistor R70.

[0027] In a preferred embodiment of the present invention, a stimulation current adjustment method of a transcranial electrical stimulator is implemented using the transcranial electrical stimulator, and the stimulation current adjustment method comprises the following steps: An electrode cap provided with electrodes is placed on the skull; the contact end of the electrode is fitted to the skull and in contact with the surface of the skull, and the inner wall of the electrode cap is wrapped outside the skull; A control signal is sent to the cranial electric stimulator through the cranial electric control mechanism, and the cranial electric stimulator outputs stimulation current to the electrode. By adjusting the setting parameters of the cranial electric control mechanism, the parameters of the stimulation current output by the cranial electric stimulator are adjusted to change the performance of the stimulation current acting on the skull by the electrode.

[0028] In a preferred embodiment of the present invention, a method for adjusting stimulation current of a transcranial electrical stimulator comprises the following steps: Step 1, obtaining brain electrical signals from the skull and performing brain electrical monitoring, wherein the brain electrical signals cover different areas of the brain; the brain electrical signals include multiple brain electrical leads; Step 2: Identify the acquired EEG signal through an EEG signal recognition algorithm and obtain EEG activity information. The EEG signal recognition algorithm includes extracting classification features from the EEG signal and using a feature classifier to identify and distinguish EEG activities based on the extracted classification features.

[0029] The present invention solves the defects existing in the technical background, and the beneficial technical effects of the present invention are: The present invention provides a transcranial electrical stimulator that is comfortable to wear and flexible to use and a stimulation current adjustment method thereof, which can adjust stimulation current output parameters according to actual use requirements, and optimize use performance and use compatibility.

[0030] In the present invention, the electrode is a flexible electrode: conventional electrodes are usually hard and cause discomfort to the user. The electrode made of flexible material can better adapt to the shape of the head and improve comfort and fit.

[0031] In the present invention, multi-channel electrodes are used: multi-channel electrodes allow multiple areas to be stimulated simultaneously, providing users with more complex stimulation patterns to better target specific brain areas or networks. BRIEF DESCRIPTION OF THE DRAWINGS

[0032] The present invention is further described below in conjunction with the accompanying drawings and embodiments.

[0033] Figure 1 is a schematic diagram of the electrode structure of a preferred embodiment of the present invention; Figure 2 is a schematic diagram of the electrode cap structure of a preferred embodiment of the present invention; Figure 3 It is a control circuit diagram of a cranial electroencephalography control chip in a cranial electroencephalography control circuit in a preferred embodiment of the present invention; Figure 4 It is a circuit diagram of LCD interface in the cranial electroencephalography control circuit of the preferred embodiment of the present invention; Figure 5 It is a voltage follower isolation circuit diagram in a cranial electroencephalogram control circuit of a preferred embodiment of the present invention; Figure 6 It is a circuit diagram of a program burning interface in a cranial electroencephalogram control circuit in a preferred embodiment of the present invention; Figure 7 It is a reference power supply circuit diagram in the cranial electroencephalography control circuit of the preferred embodiment of the present invention; Figure 8 is a structural schematic diagram of a constant current source circuit according to a preferred embodiment of the present invention; Fig. 9 It is a schematic diagram of the structure of an impedance detection circuit according to a preferred embodiment of the present invention. DETAILED DESCRIPTION

[0034] The present invention will now be further described in detail with reference to the accompanying drawings and embodiments. These drawings are simplified schematic diagrams that only illustrate the basic structure of the present invention in a schematic manner, and therefore only show the components related to the present invention.

[0035] It should be noted that if there are directional indications (such as up, down, bottom, top, etc.) involved in the embodiments of the present invention, the directional indication is only used to explain the relative position relationship, movement, etc. between the components in a certain specific posture. If the specific posture changes, the directional indication will also change accordingly. The terms "first" and "second" are only used for descriptive purposes and cannot be understood as indicating or implying relative importance or implicitly indicating the number of technical features indicated. Therefore, the features defined as "first" and "second" may explicitly or implicitly include one or more of the features. Unless otherwise clearly specified and defined, the terms "set", "connected", and "connected" should be understood in a broad sense, for example, it can be a fixed connection, a detachable connection, or an integral connection; it can be directly connected, or indirectly connected through an intermediate medium, or it can be the internal connection of two components. For ordinary technicians in this field, the specific meanings of the above terms in the present invention can be understood according to specific circumstances.

[0036] Transcranial Electrical Stimulation (tES) is a non-invasive neuromodulation technology that delivers low-intensity current to the brain through electrodes to regulate neural activity. It includes many forms, such as transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), transcranial pulsed electrical stimulation (tPCS), transcranial random noise stimulation (tRNS), etc.

[0037] Among them, transcranial direct current stimulation (tDCS) is a non-invasive transcranial stimulation method, and the stimulation effect has polarity characteristics. Anode stimulation increases the excitability of the cortex, while cathode stimulation reduces the excitability of the cortex. The effect after the stimulation depends on the intensity and duration of the stimulation. If the stimulation lasts long enough, the change in cortical excitability after the stimulation can last up to 1 hour. By adjusting the duration and intensity of the stimulation, the duration of the post-stimulation effect can be controlled.

[0038] Among them, transcranial alternating current stimulation (tACS) is to make changes in cortical excitability occur at specific frequencies. It involves sinusoidal changes in tES amplitude occurring at specific frequencies, based on intracranial work showing that changes in local field potentials are synchronized with externally applied fields. In one of the first instances, tACS was applied at a single alpha frequency (measured in the occipital cortex), and an increase in alpha power was shown during electroencephalogram (EEG) measurements after tACS compared to before. In addition, when taACS was applied over a range of frequencies (4-16Hz), an increase in alpha power was observed at 10H, a decrease in power, and eventually a gradual disappearance with the use of frequencies outside the 8-12Hz band.

[0039] Among them, transcranial pulsed electrical stimulation (tPCS) is a technology that uses short, high-intensity pulsed current to stimulate the brain. Pulsed electrical stimulation can produce a stronger stimulation effect, and it can produce a higher electric field strength in a short time. And by adjusting the pulse width, different intensities of stimulation current are generated. This stimulation method can be used to study the brain's neural network and cognitive function, as well as to treat certain neuropsychiatric diseases.

[0040] Among them, transcranial random noise stimulation (tRNS) is a specific form of transcranial electrical stimulation technology that regulates the neuronal activity of the cerebral cortex by applying alternating current with random frequency and amplitude (i.e., random noise current) to the brain. tRNS has different action characteristics from tDCS and tACS. tRNS uses alternating current with random frequency and amplitude to affect cognitive functions such as visual perception through mechanisms such as stochastic resonance (SR). An important feature of tRNS is that it has a higher skin perception threshold. Under tDCS conditions, the 50% skin perception threshold of the subjects is 400μA, while under tRNS conditions, the 50% skin perception threshold of the subjects is 1200μA. Embodiment 1

[0041] like Figure 1 , Figure 2 As shown, a transcranial electrical stimulator includes: an electrode cap mounted on the skull, the electrode cap is provided with electrodes in contact with the skull, the electrodes are electrically connected to a cranial electrical stimulator, the cranial electrical stimulator is electrically connected to a cranial electrical control mechanism, and the cranial electrical stimulator and / or the cranial electrical control mechanism are connected to a power supply. In this embodiment, the transcranial electrical stimulator is a multi-channel electrode transcranial electrical stimulation analyzer.

[0042] Specifically, the electrode cap is used to fix the electrode and stably wear it on the skull. The electrode cap is a saline electrode cap, which includes an elastic cap body with an electrode positioning hole.

[0043] Specifically, the electrode includes a metal piece connected to the stimulation current output end of the cranial electrical stimulator; a conductive rubber is provided on the metal piece; or a plant fiber layer soaked in saline is provided on the metal piece; a conductive rubber and a plant fiber layer soaked in saline are provided on the metal piece. The electrode is used to make electrical contact with the skull and provide electrical stimulation to the skull. In this embodiment, the electrode is a saline electrode; the saline electrode includes an electrode base and an electrode head, the electrode base is provided at the electrode positioning hole on the cap body, a jack is provided in the middle of the electrode base, a metal piece is inserted into the jack, and the plant fiber layer soaked in saline connected to the metal piece is attached to the cap body, and the plant fiber layer soaked in saline is in contact with the scalp of the skull. In this embodiment, the electrode is made of flexible materials (such as silicone and conductive fabrics), which can better adapt to the shape of the head and improve comfort and fit.

[0044] Specifically, the cranial electrical stimulator is used to generate and output a stimulation current. The stimulation waveform output by the electrode is one or more of a direct current, a sine wave, a sawtooth wave, and a pulse wave.

[0045] Specifically, the cranial electrical control mechanism is used to adjust the parameters of the stimulation current output by the cranial electrical stimulator. The parameters of the stimulation current include current intensity, frequency, and duration. Embodiment 2

[0046] Based on the first embodiment, Figure 1-Figure 9 As shown, the cranial electrostatic control mechanism includes a cranial electrostatic control circuit connected to the cranial electrostatic stimulator and the electrode, and the cranial electrostatic control circuit includes: a cranial electrostatic control chip, the crystal oscillator pin of the cranial electrostatic control chip is also connected to the crystal oscillator circuit, the ADC pins of the cranial electrostatic control chip are grounded through capacitors, the DAC pin of the cranial electrostatic control chip is connected to the input end of the voltage follower isolation circuit, the output end of the voltage follower isolation circuit is connected to the input end of the constant current source circuit, the switch pin of the cranial electrostatic control chip is connected to the switch circuit, and the internal power pin of the cranial electrostatic control chip is connected to the VDD chip power module; it also includes a program burning interface circuit, a reference power supply circuit, and an LCD interface circuit connected to the cranial electrostatic control chip.

[0047] Further, such as Figure 3As shown, the cranial electrostatic control chip in the cranial electrostatic control circuit uses the stm32f103rct6 chip. More specifically, the stm32f103rct6 chip used in the cranial electrostatic control chip is a 32-bit microcontroller with an internal 12-bit ADC and DAC, which can generate DC, sine wave, sawtooth wave (noise wave) and pulse wave by hardware. The cranial electrostatic control chip belongs to the control core of the electrical stimulation system, which can realize impedance detection, stimulation waveform generation, LCD touch screen display and human-computer interaction operation. Furthermore, the PBO pin of the cranial electrostatic control chip is connected to the VCC power supply through the light-emitting diode LED2 and the resistor R88; the PB2 pin of the cranial electrostatic control chip is grounded through the resistor R14; the BOOT pin of the cranial electrostatic control chip is grounded through the resistor R13; and a pair of ADC pins of the cranial electrostatic control chip are grounded through capacitors C89 and C90 respectively. Further, the VDD chip power module includes: a VDD power chip, the VDD pin of the VDD power chip is connected to the VCC power supply at a common point, the VBAT pin of the VDD power chip is connected to the VCC power supply through one path, and the other path is grounded through a capacitor C5, the VDDA pin of the VDD power chip is connected to the VCC power supply through a resistor R11, and the other path is connected to the reference power supply REF3.3V through a resistor R89, and the VSS pin and VSSA pin of the VDD power chip are grounded at a common point. Further, the switch circuit includes: a switch SW1, one end of the switch SW1 is connected to the NRAT pin of the cranial electrostatic control chip, the other end of the switch SW1 is grounded, and the two ends of the switch SW1 are connected to a capacitor C6, and the NRAT pin is connected to the VCC power supply through a resistor R12. Specifically, the crystal oscillator circuit includes a resistor R10 and a crystal oscillator X1 connected in parallel to a pair of crystal oscillator pins, and the two ends of the crystal oscillator X1 are grounded through capacitors C3 and C4 respectively. Furthermore, the VCC power supply is grounded through capacitors C11, C12, C13, C14, and C15 connected in parallel.

[0048] like Figure 6 As shown, the program burning interface circuit includes: an interface connector, pins 5 and 6 of the interface connector are grounded at a common point; pin 1 of the interface connector is grounded; pin 2 is connected to two paths, one is connected to the VCC power supply, and the other is grounded through a capacitor C27; pin 3 is used as an SLK terminal to connect to the VCC power supply through a resistor R6, and pin 4 is used as a DIO terminal to connect to the VCC power supply through a resistor R5.

[0049] like Figure 7 As shown, the reference power supply circuit includes: a voltage reference chip, the IN terminal of the voltage reference chip leads to two paths, one path is connected to the VCC power supply, and the other path is grounded through a capacitor C97; the OUT terminal of the voltage reference chip leads to two paths, one path leads to the reference power supply REF3.3V, and the other path is grounded through parallel capacitors C98 and C106; the GND terminal of the voltage reference chip is grounded.

[0050] like Figure 4 As shown, the LCD interface circuit includes: interface connector 2, pin 5 and pin 6 of interface connector 2 are grounded at a common point; pin 1 of interface connector 2 is grounded; pin 2 of interface connector 2 is connected to U1_TXD pin of cranial electric control chip; pin 3 of interface connector 2 is connected to U1_RXD pin of cranial electric control chip, and pin 4 of interface connector 2 is connected to VCC power supply.

[0051] like Figure 5 As shown, the voltage follower isolation circuit includes: an operational amplifier chip, the OUTA pin of the operational amplifier chip is connected to the -INA pin; the +INA pin of the operational amplifier chip is connected to the DAC_IN2 pin of the cranial electrostatic control chip, and the V- pin of the operational amplifier chip is grounded; the V+ pin of the operational amplifier chip leads to two paths, one is connected to the VCC power supply, and the other is grounded through capacitor C107; the OUTB pin of the operational amplifier chip is connected to the -INB pin, and is connected to the DAC_OUT1 pin of the impedance operational amplifier chip in the constant current source circuit; the +INB pin of the operational amplifier chip is connected to the DAC_IN1 pin of the cranial electrostatic control chip.

[0052] Specifically, Figure 3-Figure 9As shown, the cranial electrical stimulator includes a constant current source circuit electrically connected to the cranial electrical control circuit, the constant current source circuit includes an input voltage source and a plurality of groups of impedance converters electrically connected to the input voltage source; each group of impedance converters includes: an impedance operational amplifier chip, the +INA pin of the impedance operational amplifier chip is connected to the OUTB pin of the operational amplifier chip of the voltage follower isolation circuit through a resistor R56, the +INA pin of the impedance operational amplifier chip is connected to the OB2 node through a resistor R60, the -INA pin of the impedance operational amplifier chip is connected to the electrode as the LMOUT terminal output stimulation current through a resistor R55, and the OUTA pin of the impedance operational amplifier chip is connected to the impedance through a resistor R59. The -INA pin of the operational amplifier chip is connected, and the two ends of the resistor R59 are connected with a capacitor C83, and the connection node of the capacitor C83 and the resistor R59 leads to the IB2 node through the resistor R62, the V- pin of the impedance operational amplifier chip is grounded through the capacitor C68, and the V- pin of the impedance operational amplifier chip is also connected to the power supply -25V of the input voltage source; the V+ pin of the impedance operational amplifier chip is grounded through the capacitor C67, and the V+ pin of the impedance operational amplifier chip is connected to the power supply +25V of the input voltage source, the OUTB pin and -INB pin of the impedance operational amplifier chip are connected to the OB2 node at the same point, and the +INB pin of the impedance operational amplifier chip is connected to the IB2 node. More specifically, the impedance converter is the core part of the circuit, which is usually composed of components such as an operational amplifier and a resistor. The Howland constant current source circuit can keep the output current constant when the load resistance value changes. The current output size of the structure circuit is controlled by voltage, and accurate stimulation current can be output by adjusting the voltage. The HOWLAND circuit consists of two operational amplifiers. The model of the operational amplifier is ADI's ADA4522-2 as the core operational amplifier. The ADA4522-2 has extremely low offset voltage (Vos<5uV) and input bias current (IbTyp50pA). The maximum error caused by these two parasitic parameters is 0.02% (when outputting 0.5mA), which can greatly avoid the problem of low output current accuracy caused by the offset parameter error of the operational amplifier. At the same time, the maximum offset temperature drift of the operational amplifier is 22nV / ℃, which can be ignored within the normal temperature range. The ADA4522 operational amplifier uses a dual power supply with a range of up to ±27.5V, which meets the voltage requirement of ±25V of the electrical stimulation system.

[0053] Specifically, Figure 3-Figure 9As shown, the cranial electrical stimulator includes an impedance detection circuit electrically connected to the cranial electrical control circuit, and the impedance detection circuit includes: an impedance detection operational amplifier chip, the +INA pin of the impedance detection operational amplifier chip is connected to the IB2 node through a resistor R69, the -INA pin of the impedance detection operational amplifier chip is connected to the OUTA pin of the impedance detection operational amplifier chip, the OUTA pin of the impedance detection operational amplifier chip is also connected to the +INB pin of the impedance detection operational amplifier chip through a resistor R71, the V- pin of the impedance detection operational amplifier chip is grounded through a capacitor C71, and the V+ pin of the impedance detection operational amplifier chip is connected to the input voltage source The impedance detection circuit uses the impedance detection operational amplifier chip to realize level conversion, and can accurately and stably convert the electrical stimulation voltage within the range of positive and negative 25V to 0-3.3V, so that the voltage is maintained within the range that the cranial electrostatic control circuit can handle, directly use the ADC of the cranial electrostatic control chip to sample the electrical stimulation output voltage, and monitor the contact status between the electrode and the skin in real time to ensure the safety and effectiveness of transcranial electrostimulation. Embodiment 3

[0054] On the basis of the first or second embodiment, a stimulation current adjustment method of a transcranial electrical stimulator is implemented by using the transcranial electrical stimulator, comprising the following steps: An electrode cap provided with electrodes is placed on the skull; the contact end of the electrode is fitted to the skull and in contact with the surface of the skull, and the inner wall of the electrode cap is wrapped outside the skull; A control signal is sent to the cranial electric stimulator through the cranial electric control mechanism, and the cranial electric stimulator outputs stimulation current to the electrode. By adjusting the setting parameters of the cranial electric control mechanism, the parameters of the stimulation current output by the cranial electric stimulator are adjusted to change the performance of the stimulation current acting on the skull by the electrode.

[0055] Specifically, multiple groups of motor groups connected to different control ends of the cranial electrostatic control mechanism are used to achieve different regulation of the motor stimulation currents in different parts of the skull. Embodiment 4

[0056] On the basis of the first embodiment, the second embodiment or the third embodiment, a stimulation current adjustment method of a transcranial electrical stimulator is implemented by using the transcranial electrical stimulator, comprising the following steps: Step 1, obtaining brain electrical signals from the skull and performing brain electrical monitoring, wherein the brain electrical signals cover different areas of the brain; the brain electrical signals include multiple brain electrical leads; Step 2: Identify the acquired EEG signal through an EEG signal recognition algorithm and obtain EEG activity information. The EEG signal recognition algorithm includes extracting classification features from the EEG signal, and based on the extracted classification features, using a feature classifier to identify and distinguish EEG activities. Embodiment 5

[0057] On the basis of the first embodiment, the second embodiment or the third embodiment, a stimulation current adjustment method of a transcranial electrical stimulator is implemented by using the transcranial electrical stimulator, comprising the following steps: Step 1, obtaining brain electrical signals from the skull and performing brain electrical monitoring, wherein the brain electrical signals cover different areas of the brain; the brain electrical signals include multiple brain electrical leads; Step 2: Identify the acquired EEG signal through an EEG signal recognition algorithm and obtain EEG activity information. The EEG signal recognition algorithm includes extracting classification features from the EEG signal, and based on the extracted classification features, using a feature classifier to identify and distinguish EEG activities.

[0058] Specifically, EEG feedback: at least 6-8 leads to obtain enough EEG signals to cover different areas of the brain for EEG monitoring. EEG signal recognition algorithm: extract classification features from EEG signals, and use EEG classifiers based on the extracted classification features to identify different EEG activities, such as alpha waves, beta waves, and slow wave activities. Perform sleep stage recognition: develop an algorithm for automatically identifying sleep stages.

[0059] In one example, since the electrical signals in the brain are too weak, the finite element head models generated in these examples can be simplified to passive or sinkless finite element head models.

[0060] When a unit current is applied to each candidate electrode set on the finite element head model in turn, the transmission matrix of the gray matter and white matter in the head tissue is calculated according to the Laplace equation to accurately evaluate the distribution of the induced electric field in the brain; Based on the convex optimization algorithm, after obtaining the electric field conditions when the same electrical stimulation parameters are applied to candidate electrodes of different layouts in sequence, the electric field distribution corresponding to each electrode layout is compared. After multiple iterations of different electrode layouts, a lead matrix is ​​generated according to the corresponding electric field distribution, and then the optimal electrode layout that meets the target electric field distribution (such as the maximum electric field strength) is obtained based on the lead matrix. Among them, the expression of the Laplace equation is: ; Laplace equation states that the divergence of the product of conductivity and potential gradient is zero, where is the conductivity, is the potential gradient, is the divergence. Electric field E = forward matrix L* activates electrode s.

[0061] In another example, if a small electrode is used to input current to achieve electrical stimulation, it is also necessary to limit the maximum current at each electrode to avoid the risks that may arise from relatively high current density, such as skin irritation and burns. Furthermore, the safety restriction condition includes all electrodes involved in the optimization and the reference electrode, and the mathematical expression of the safety restriction condition is: g2(s) = sm ≤ Iind; g3(s) = ∑Msm ≤ Iind; where s represents the applied electrical stimulation parameters, and the electrical stimulation parameters include: stimulation time, stimulation intensity and frequency; M is the number of leads; Iind is the current that can be input to a single electrode as specified by the safety protocol. Among them, g2(s) can be directly limited by the model code and no additional consideration is required. The value of g2(s) corresponds to the electrode involved in the optimization, and the value of g3(s) corresponds to the reference electrode.

[0062] In another example, based on physiological data, it is determined when the user enters a specific sleep activity state, such as REM (rapid eye movement) sleep, NREM (non-rapid eye movement) sleep. Once the user enters the preset sleep activity stage, the device will automatically start the corresponding stimulation mode. Embodiment 6

[0063] On the basis of the fifth embodiment, when the user enters the preset sleep activity stage in the brain electrical activity, the closed-loop adaptive transcranial electrical stimulation mode is started, and the closed-loop adaptive transcranial electrical stimulation method of the closed-loop adaptive transcranial electrical stimulation mode includes the following steps: Step SA1, select the test paradigm according to the usage requirements; Step SA2, presetting the control target as the level setting for evaluating the brain state of the subject after the control; Step SA3, presetting the control model and determining the output parameters of transcranial electrical stimulation; Step SA4, collecting and processing EEG data to obtain the EEG state evaluation result of the subject; Step SA5, collect behavioral data and conduct paradigm evaluation; Step SA6, generating a fusion brain state evaluation algorithm based on the EEG evaluation algorithm and the paradigm evaluation algorithm, and calculating the subject state evaluation result; Step SA7, calculating the deviation between the test subject's state evaluation result and the preset control target; Step SA8, calling the control model to control the transcranial electrical stimulation output parameters according to the deviation value; Step SA9, repeating steps SA3 to SA8, cyclically evaluating the online test and regulation until there is no deviation between the "subject state evaluation result and the preset regulation target". Embodiment 7

[0064] Based on Example 6, the specific implementation of transcranial electrical stimulation (tES) generally includes the following steps: Preparation stage: Determine the purpose of use or research and select the corresponding transcranial electrical stimulation type (transcranial electrical stimulation types include tDCS, tACS, tRNS, etc.).

[0065] Conduct medical assessments to ensure that the subject or patient has no inappropriate conditions, such as implanted medical devices, scalp injuries or infections, etc. Obtain informed consent from the subject or patient.

[0066] Stimulus package design: Determine the stimulation parameters, including current intensity, frequency, duration, stimulation site, etc., according to the treatment purpose or research design.

[0067] Design a stimulation plan, including the duration of a single stimulation, treatment interval, total number of treatments, etc.

[0068] Electrode placement: Electrodes are placed on the scalp at the appropriate locations according to the stimulation protocol. One electrode acts as the anode (positive) and the other as the cathode (negative). The location of the electrodes depends on the target brain area, for example, for the treatment of depression, the anode is usually placed on the left prefrontal lobe and the cathode is placed on the contralateral temporal region or other locations on the scalp.

[0069] Connect the device: Connect the electrodes to the transcranial electrical stimulation device via wires.

[0070] Device start: Start stimulation according to the preset parameters.

[0071] Implementation of stimulation: During stimulation, monitor the subject or patient's response to ensure comfort and safety. If discomfort or abnormal reactions occur, stimulation should be stopped immediately and the cause evaluated.

[0072] End and record: After the stimulation is completed, turn off the device and remove the electrodes. Record the stimulation parameters and the subject or patient's response for subsequent analysis and evaluation.

[0073] Follow-up evaluation: After the stimulation is completed, the subject or patient is evaluated to observe the short-term and long-term effects. Based on the evaluation results, the stimulation regimen is adjusted to optimize the treatment effect. Embodiment 8

[0074] The present invention can select different stimulation modes (such as tDCS, tACS, tPCS, tRNS) according to needs. Stimulation parameters such as stimulation time, stimulation intensity and frequency are set through the control system. Electrodes are placed at specific locations on the scalp, and current is transmitted to the cerebral cortex through the electrodes. Stimulation causes changes in the potential of the nerve cell membrane, thereby affecting the excitability of the neurons.

[0075] Stimulation mode: tDCS, tACS, tPCS, tRNS.

[0076] Stimulation waveform: DC, sine wave, sawtooth wave (noise wave) and pulse wave; current accuracy: uA (0.01mA); stimulation current: 0~2mA. The selection of specific values ​​can be dynamically adjusted according to the stimulation type and research purpose.

[0077] Stimulation frequency: For tACS and tPCS, the frequency range is 0.5 Hz to 500 Hz; the specific value can be dynamically adjusted according to the stimulation type and research purpose.

[0078] Stimulation channels: 8 channels; Power supply: lithium battery; Electrode cap: saline electrode cap; Safety function: real-time impedance detection of all channels; Duration: The stimulation time can range from a few minutes to a few hours.

[0079] Safety measures: Consider maximum current limitation to prevent electric shock (to prevent damage to the electrode contact site). Monitoring system (impedance real-time detection system) ensures that the (stimulation current) current is within the safety range of existing technology.

[0080] Working principle: The present invention can select different stimulation modes (such as tDCS, tACS, tPCS, tRNS) according to needs. Stimulation parameters such as stimulation time, stimulation intensity and frequency are set by the control system. Electrodes are placed at specific positions on the scalp, and current is transmitted to the cerebral cortex through the electrodes. Stimulation causes changes in the potential of nerve cell membranes, thereby affecting the excitability of neurons. Transcranial pulsed electrical stimulation (tPCS) in the present invention is a technology that uses short, high-intensity pulsed currents to stimulate the brain. Pulsed electrical stimulation can produce a stronger stimulation effect and can produce a higher electric field strength in a short time. And by adjusting the pulse width, stimulation currents of different intensities can be generated.

[0081] The above specific implementation methods are specific support for the scheme ideas proposed in the present invention, and cannot be used to limit the protection scope of the present invention. Any equivalent changes or equivalent modifications made on the basis of this technical scheme in accordance with the technical ideas proposed in the present invention still fall within the scope of protection of the technical scheme of the present invention.

Claims

1. A transcranial electrical stimulator, characterized in that: include: An electrode cap sleeved on the skull, the electrode cap is provided with electrodes in contact with the skull, the electrodes are electrically connected to a skull electrical stimulator, the skull electrical stimulator is electrically connected to a skull electrical control mechanism, and the skull electrical stimulator and / or the skull electrical control mechanism are connected to a power supply; The electrode cap is used to fix the electrode and is worn on the skull; The electrode is used to electrically contact the skull to provide electrical stimulation to the skull; The cranial electrical stimulator is used to generate and output stimulation current; The cranial electrical control mechanism is used to adjust the parameters of the stimulation current output by the cranial electrical stimulator.

2. The transcranial electrical stimulator according to claim 1, characterized in that: The electrode comprises a metal piece connected to a stimulation current output terminal of the cranial electrical stimulator; The metal piece is provided with conductive rubber; or, the metal piece is provided with a plant fiber layer soaked in salt water; or, the metal piece is provided with conductive rubber and a plant fiber layer soaked in salt water; And / or, the cranial electrical stimulator is a multi-channel electrode transcranial electrical stimulation analyzer.

3. The transcranial electrical stimulator according to claim 2, characterized in that: The electrode cap is a salt water electrode cap, which includes an elastic cap body, and an electrode positioning hole is provided on the cap body; The electrode used is a saline electrode; the saline electrode includes an electrode base and an electrode head, the electrode base is arranged at the electrode positioning hole on the cap body, a socket is arranged in the middle of the electrode base, a metal piece is passed through the socket, a plant fiber layer soaked in saline connected to the metal piece is attached to the cap body, and the plant fiber layer soaked in saline is in contact with the scalp of the skull.

4. The transcranial electrical stimulator according to claim 3, characterized in that: The parameters of the stimulation current include current intensity, frequency, and duration; And / or, the stimulation waveform output by the electrode is one or more of direct current, sine wave, sawtooth wave, and pulse wave.

5. The transcranial electrical stimulator according to claim 4, characterized in that: The cranial electrical control mechanism includes a cranial electrical control circuit connected to the cranial electrical stimulator and the electrodes, and the cranial electrical control circuit includes: A cranial electrostatic control chip, wherein the crystal oscillator pin of the cranial electrostatic control chip is also connected to a crystal oscillator circuit, the ADC pins of the cranial electrostatic control chip are grounded through capacitors, the DAC pin of the cranial electrostatic control chip is connected to the input end of a voltage follower isolation circuit, the output end of the voltage follower isolation circuit is connected to the input end of a constant current source circuit, the switch pin of the cranial electrostatic control chip is connected to a switch circuit, and the internal power supply pin of the cranial electrostatic control chip is connected to a VDD chip power supply module; It also includes a program burning interface circuit, a reference power supply circuit, and an LCD interface circuit connected to the cranial electromechanical control chip.

6. The transcranial electrical stimulator according to claim 5, characterized in that: The VDD chip power module comprises: a VDD power chip, a VDD pin of the VDD power chip is connected to a VCC power supply at a common point, a VBAT pin of the VDD power chip is connected to the VCC power supply at one point, and the other is grounded through a capacitor C5, a VDDA pin of the VDD power chip is connected to the VCC power supply at one point through a resistor R11, and the other is connected to a reference power supply REF3.3V through a resistor R89, and a VSS pin and a VSSA pin of the VDD power chip are grounded at a common point; And / or, the switch circuit includes: a switch SW1, one end of the switch SW1 is connected to the NRAT pin of the cranial electroencephalography control chip, the other end of the switch SW1 is grounded, and a capacitor C6 is connected in parallel to both ends of the switch SW1, and the NRAT pin is connected to the VCC power supply through a resistor R12; And / or, the crystal oscillator circuit includes a resistor R10 and a crystal oscillator X1 connected in parallel to a pair of crystal oscillator pins, and both ends of the crystal oscillator X1 are grounded through capacitors C3 and C4 respectively; And / or, the program burning interface circuit includes: an interface connector 1, wherein pins 5 and 6 of the interface connector 1 are grounded at a common point; pin 1 of the interface connector 1 is grounded; pin 2 of the interface connector 1 is connected to two paths, one path is connected to the VCC power supply, and the other path is grounded through a capacitor C27; pin 3 of the interface connector 1 is connected to the VCC power supply through a resistor R6 as an SLK terminal, and pin 4 of the interface connector 1 is connected to the VCC power supply through a resistor R5 as a DIO terminal; And / or, the reference power supply circuit comprises: a voltage reference chip, wherein the IN terminal of the voltage reference chip leads to two paths, one of which is connected to the VCC power supply, and the other is grounded through a capacitor C97; the OUT terminal of the voltage reference chip leads to two paths, one of which leads to the reference power supply REF3.3V, and the other is grounded through a capacitor C98 and a capacitor C106 connected in parallel; and the GND terminal of the voltage reference chip is grounded; And / or, the LCD interface circuit includes: interface connector 2, pin 5 and pin 6 of the interface connector 2 are grounded at a common point; pin 1 of the interface connector 2 is grounded; pin 2 of the interface connector 2 is connected to the U1_TXD pin of the cranial electric control chip; pin 3 of the interface connector 2 is connected to the U1_RXD pin of the cranial electric control chip, and pin 4 of the interface connector 2 is connected to the VCC power supply; And / or, the voltage follower isolation circuit includes: an operational amplifier chip, the OUTA pin of the operational amplifier chip is connected to the -INA pin; the +INA pin of the operational amplifier chip is connected to the DAC_IN2 pin of the cranial electrostatic control chip, and the V- pin of the operational amplifier chip is grounded; the V+ pin of the operational amplifier chip leads to two paths, one is connected to the VCC power supply, and the other is grounded through capacitor C107; the OUTB pin of the operational amplifier chip is connected to the -INB pin, and is connected to the DAC_OUT1 pin of the impedance operational amplifier chip in the constant current source circuit; the +INB pin of the operational amplifier chip is connected to the DAC_IN1 pin of the cranial electrostatic control chip.

7. The transcranial electrical stimulator according to claim 6, characterized in that: The cranial electrical stimulator comprises a constant current source circuit electrically connected to the cranial electrical control circuit, wherein the constant current source circuit comprises an input voltage source and a plurality of groups of impedance converters electrically connected to the input voltage source; Each impedance converter includes: an impedance operational amplifier chip, wherein the +INA pin of the impedance operational amplifier chip is connected to the OUTB pin of the operational amplifier chip of the voltage follower isolation circuit through a resistor R56, the +INA pin of the impedance operational amplifier chip is connected to the OB2 node through a resistor R60, the -INA pin of the impedance operational amplifier chip is connected to the electrode as the LMOUT terminal output stimulation current through a resistor R55, the OUTA pin of the impedance operational amplifier chip is connected to the -INA pin of the impedance operational amplifier chip through a resistor R59, and both ends of the resistor R59 are connected to the -INA pin of the impedance operational amplifier chip. A capacitor C83 is connected in parallel, and the connection node between capacitor C83 and resistor R59 leads to the IB2 node through resistor R62, the V- pin of the impedance operational amplifier chip is grounded through capacitor C68, and the V- pin of the impedance operational amplifier chip is also connected to the power supply -25V of the input voltage source; the V+ pin of the impedance operational amplifier chip is grounded through capacitor C67, and the V+ pin of the impedance operational amplifier chip is connected to the power supply +25V of the input voltage source, the OUTB pin and -INB pin of the impedance operational amplifier chip are connected to the OB2 node at a common point, and the +INB pin of the impedance operational amplifier chip is connected to the IB2 node.

8. The transcranial electrical stimulator according to claim 7, characterized in that: The cranial electrical stimulator includes an impedance detection circuit electrically connected to the cranial electrical control circuit, and the impedance detection circuit includes: an impedance detection operational amplifier chip, the +INA pin of the impedance detection operational amplifier chip is connected to the IB2 node through a resistor R69, the -INA pin of the impedance detection operational amplifier chip is connected to the OUTA pin of the impedance detection operational amplifier chip, the OUTA pin of the impedance detection operational amplifier chip is also connected to the +INB pin of the impedance detection operational amplifier chip through a resistor R71, the V- pin of the impedance detection operational amplifier chip is grounded through a capacitor C71, and the V+ pin of the impedance detection operational amplifier chip is connected to the input The power supply +25V of the voltage source is connected, and the V+ pin of the impedance detection operational amplifier chip is also grounded through capacitor C72, the OUTB pin of the impedance detection operational amplifier chip is connected to the ADC pin of the cranial electrostatic control chip, the ADC pin of the cranial electrostatic control chip is also grounded through a voltage regulator diode D9, and the OUTB pin of the impedance detection operational amplifier chip is also connected to the -INB pin of the impedance detection operational amplifier chip through resistors R72 and R80, the -INB pin of the impedance detection operational amplifier chip is also grounded through resistor R73, and the +INB pin of the impedance detection operational amplifier chip is connected to the reference power supply REF1.2V through resistor R70.

9. A method for regulating stimulation current of a transcranial electrical stimulator, characterized in that: The method for adjusting the stimulation current is implemented by using the transcranial electrical stimulator according to any one of claims 1 to 8, and comprises the following steps: An electrode cap provided with electrodes is placed on the skull; the contact end of the electrode is fitted to the skull and in contact with the surface of the skull, and the inner wall of the electrode cap is wrapped outside the skull; A control signal is sent to the cranial electric stimulator through the cranial electric control mechanism, and the cranial electric stimulator outputs stimulation current to the electrode. By adjusting the setting parameters of the cranial electric control mechanism, the parameters of the stimulation current output by the cranial electric stimulator are adjusted to change the performance of the stimulation current acting on the skull by the electrode.

10. The stimulation current adjustment method of the transcranial electrical stimulator according to claim 9, characterized in that: The following steps are involved: Step 1, obtaining an EEG signal from the skull and performing EEG monitoring, wherein the EEG signal covers different areas of the brain; the EEG signal includes a plurality of EEG leads; Step 2, identifying the acquired EEG signal through an EEG signal recognition algorithm and acquiring EEG activity information, wherein the EEG signal recognition algorithm includes extracting classification features from the EEG signal, and using a feature classifier based on the extracted classification features to identify and distinguish EEG activities.

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