Medicine purification equipment for biological medicine processing

Abstract

The invention discloses medicine purification equipment for biological medicine processing in the technical field of biological medicine processing, and the medicine purification equipment comprises a mixing box, a partition plate and a heating box, the top of the mixing box is provided with a feeding assembly, the partition plate is provided with a plurality of rotary storage assemblies and a plurality of fixed stirring assemblies, and the bottom of the partition plate is provided with a lifting ring plate and a lifting assembly; a driving assembly connected with the rotary material storage assembly is further arranged in the mixing box, a discharging assembly, a first heater and a second heater are arranged in the heating box, and through the feeding assembly, the rotary material storage assembly, the fixed stirring assembly and the discharging assembly, to-be-purified materials are continuously fed, mixed, heated and discharged; the plurality of rotary material storage assemblies rotate relative to the fixed stirring assembly through the driving assembly, so that materials can be fully mixed and stirred; purified materials are equally divided into a plurality of rotary material storage assemblies, so that the handling capacity of each rotary material storage assembly is reduced, and the contact area of the whole liquid material and hot water is increased.

Description

Technical Field

[0001] The invention relates to the technical field of biomedicine processing, in particular to a drug purification device used for biomedicine processing. Background Art

[0002] In biopharmaceutical processing, the raw materials need to be pre-processed, such as crushing, cooking, pressing, etc., to obtain the corresponding liquid drug materials, and then the liquid materials need to be further purified.

[0003] Commonly used purification processes include treatment agent mixing and heating, etc. For example, the patent publication number is CN222287017U, which is a drug purification device for biopharmaceutical processing. Its structure mainly includes an outer cylinder, a sealing cover located on the upper part of the outer cylinder, a placement plate located at the bottom end of the inner part of the outer cylinder, a purification cylinder located on the placement plate, and a fixing component arranged on the outside of the outer cylinder, wherein the fixing component is used to fix purification cylinders of different specifications, and at the same time can facilitate the staff to disassemble and clean the purification cylinder; wherein a stirring component is provided on the sealing cover, and a heating component is provided inside the purification cylinder, and is used to heat the medicine inside the purification cylinder.

[0004] The above-mentioned device can stir, mix and heat the drugs, but when the above-mentioned device is in use, all the drugs are located in the same purification cylinder. When the amount of drugs is large, the workload of the single stirring component and the heating component increases, and the contact area between the drugs and the purification cylinder or the heating component is relatively small, the thermal conductivity of the purification cylinder or the heating component is reduced, and the heating is prone to unevenness and reduced heating efficiency.

[0005] Based on this, the present invention designs a drug purification device for biopharmaceutical processing to solve the above problems. Summary of the invention

[0006] The object of the present invention is to provide a drug purification device for biopharmaceutical processing to solve the problems raised in the above background technology.

[0007] To achieve the above object, the present invention provides the following technical solutions: A drug purification device for biopharmaceutical processing, comprising a cylindrical mixing box and a heating box located at the bottom of the mixing box, wherein the inner side wall and the bottom of the heating box are respectively provided with a first heater and a second heater, and a drain pipe and a valve are provided on one side of the bottom of the heating box; A circular partition is fixed between the mixing box and the heating box, a lifting assembly and a horizontal lifting ring plate are provided at the bottom center of the partition, a plurality of rotating material storage assemblies are evenly arranged and rotatably connected on the lifting ring plate along the circumferential direction, the top of the rotating material storage assembly passes through the partition and extends into the mixing box, a driving assembly is provided at the lower part of the inner cavity of the mixing box, and the driving assembly is correspondingly connected to the plurality of rotating material storage assemblies; Each rotating material storage assembly is provided with a fixed stirring assembly, the top end of the fixed stirring assembly extends out of the rotating material storage assembly and is fixedly connected to the top of the mixing box through an air guide structure, and the top end of the air guide structure extends out of the mixing box; A feeding assembly is provided in the middle of the top of the mixing box, a plurality of feeding ports are evenly arranged at the bottom of the feeding assembly along the circumferential direction, and a sealing assembly is provided in the feeding assembly, a feeding assembly is provided on the upper part of the inner wall of the heating box, and the bottoms of the plurality of rotating storage assemblies are correspondingly connected to the feeding assembly.

[0008] Preferably, the rotating material storage assembly includes a material storage barrel rotatably connected to the lifting ring plate, a vertical center tube is fixed at the center of the bottom surface of the material storage barrel, and a discharge port and a valve are provided on one side of the bottom, the top end of the center tube is located at the upper part of the inner cavity of the material storage barrel, and an air vent is provided at the center of the top end, an annular top plate is fixed at the top of the material storage barrel, and a plurality of vertical heat-conducting ribs are evenly fixed along the circumferential direction at the bottom of the annular top plate, the inner side edge of the heat-conducting rib is fixedly connected to the outer side wall of the material storage barrel, the bottom end is located at the lower part of the outer side wall of the material storage barrel, and the material storage barrel is correspondingly connected to the driving assembly through the heat-conducting ribs; A rotating ring seat is rotatably connected to the position of each storage barrel on the partition, and the storage barrel is slidably connected to the rotating ring seat. A sliding groove is provided on the inner side wall of the rotating ring seat at the position corresponding to each heat-conducting rib, and the heat-conducting rib is slidably connected to the sliding groove. A first gear ring is fixed to the outer side of the rotating ring seat, and multiple first gear rings are correspondingly connected to the driving assembly.

[0009] Preferably, the fixed stirring assembly includes a fixed tube slidably connected to the outside of the central tube, the top end of the fixed tube is fixedly connected to the air guide structure, the bottom end is close to the bottom of the inner cavity of the storage barrel, and is fixed with an annular sealing plate, and the position of the sealing plate corresponds to the position of the annular top plate, and a plurality of stirring plates are evenly fixed on the outside of the fixed tube along the circumferential direction, and the outer side edge of the stirring plate is located in the inner hole area of ​​the annular top plate; The air guide structure includes an annular tube fixed to the top of the mixing box inner cavity, the top ends of multiple fixed tubes are fixedly connected to the bottom of the annular tube, a vertical exhaust pipe is fixed to the top of the annular tube, and the top end of the exhaust pipe passes through and extends out of the mixing box.

[0010] Preferably, an annular spring groove is provided at the bottom of the annular top plate corresponding to the position of the sealing plate, a plurality of springs are evenly arranged in the annular groove, and a sealing ring is connected through the bottom ends of the plurality of springs, and the bottom of the sealing ring extends out of the spring groove.

[0011] Preferably, the driving assembly includes an annular boss fixed to the top of the partition, a rotating ring plate is rotatably connected to the annular boss, a second gear ring is fixed to the inner side of the rotating ring plate, multiple first gear rings are meshed with the inner side of the second gear ring, a transmission bevel gear ring is fixed on the outer surface of the rotating ring plate, a driving bevel gear is rotatably connected to the inner wall of the mixing box, the driving bevel gear is meshed with the transmission bevel gear ring, and the outer end of the driving bevel gear is connected to a motor.

[0012] Preferably, the feeding assembly includes a feeding barrel fixed at the top center of the mixing box, the bottom end of the feeding barrel extends into the mixing box, and an annular diverter groove is fixed on the outer side of the bottom end, a plurality of connecting grooves are evenly arranged on the bottom of the outer wall of the feeding barrel, and are connected with the inner cavity of the diverter groove through the connecting grooves, a sealing assembly is provided on the top of the diverter groove, and a plurality of diverter pipes are evenly fixed and connected on the outer wall along the circumferential direction, the diverter pipes are arranged along the radial direction of the diverter groove, and correspond one by one to the positions of a plurality of storage barrels, the outer end of the diverter pipe extends to the top of the storage barrel, and a feeding port is provided at the bottom of the outer end corresponding to the inner hole area of ​​the annular top plate.

[0013] Preferably, a fixing block is provided at the outer end of the shunt tube, and is fixed to the outer wall of the fixed tube through the fixing block. The connection between the fixing block and the fixed tube improves the position stability of the outer end of the shunt tube and avoids the outer end of the shunt tube from being suspended.

[0014] Preferably, the sealing assembly includes an annular sealing plug slidably connected to the upper part of the inner cavity of the diverter groove, the top end of the sealing plug extends out of the diverter groove and is fixed with an annular spring plate, a plurality of springs are evenly connected between the top of the spring plate and the top of the inner cavity of the mixing box, and an annular first electromagnet and a second electromagnet are respectively fixed at relative positions of the spring plate and the top of the inner cavity of the mixing box, and the first electromagnet and the second electromagnet are electrically connected to a power supply and a switch.

[0015] Preferably, a premixing structure is provided in the feed barrel, and the premixing structure includes a rotating shaft rotatably connected to the center of the feed barrel, the bottom end of the rotating shaft extends out of the bottom end of the feed barrel and is connected to a motor, and a plurality of rotating plates are evenly arranged on the rotating shaft along the circumferential direction.

[0016] Preferably, the material discharge assembly includes a material discharge ring tube fixed to the upper part of the inner wall of the heating box, the material discharge ring tube is connected to a discharge pipe, and one end of the discharge pipe extends out of the heating box, the top of the material discharge ring tube is evenly arranged and rotatably connected with multiple vertical rotating tubes along the circumferential direction, one side of the rotating tube is connected and fixed with a material guide pipe, one end of the material guide pipe is located below the discharge port of the storage barrel, and is connected and fixed with a material receiving trough, an adjusting gear is fixed to the top of the rotating tube, and an adjusting gear ring is rotatably connected to the inner wall of the heating box, multiple adjusting gears are meshed with the adjusting gear ring, and a micro motor is connected to the top of one of the adjusting gears.

[0017] Preferably, the lifting assembly includes a vertical screw rotatably connected to the center of the bottom of the partition, the top of the screw extends out of the partition and is connected to a motor, an annular support seat is fixed at the center of the bottom of the inner cavity of the heating box, and the bottom end of the screw is rotatably connected to the support seat, the upper part of the screw is threadedly connected to the lifting seat, and a plurality of inclined connecting frames are evenly fixed on the outer side of the lifting seat along the circumferential direction, and the outer ends of the plurality of connecting frames are fixedly connected to the inner ring side of the lifting ring plate.

[0018] Compared with the prior art, the present invention has the following beneficial effects: 1. The present invention provides a mixing box, a partition and a heating box, and provides a feeding component in the mixing box, a rotating material storage component and a fixed stirring component on the partition, and a material discharge component in the heating box, so that the material to be purified can be continuously fed, mixed, heated and discharged, making the drug purification process faster and more convenient; 2. The present invention uses a driving assembly to make multiple rotating material storage assemblies rotate relative to a fixed stirring assembly, so that the materials can be fully mixed and stirred to improve the processing effect; 3. The present invention reduces the processing volume in each rotating storage component by equally loading the purified material into multiple rotating storage components. The portion processing method can increase the contact area between the entire liquid material and hot water, thereby improving thermal conductivity and heating efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0019] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the accompanying drawings required for describing the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of the present invention. For ordinary technicians in this field, other accompanying drawings can be obtained based on these accompanying drawings without paying creative work.

[0020] Figure 1 It is a schematic diagram of the structure of the present invention; Figure 2 It is a schematic diagram of the internal structure of the mixing box of the present invention; Figure 3 This is a schematic diagram of the bottom structure of the heating box of the present invention; Figure 4 It is a schematic diagram of the top structure of the storage barrel of the present invention; Figure 5 It is a schematic diagram of the bottom structure of the storage barrel of the present invention; Figure 6 It is a schematic structural diagram of the feed barrel of the present invention; Figure 7 for Figure 2 Schematic diagram of the structure at A in the middle; Figure 8 for Figure 2 Schematic diagram of the structure at B in the middle; Fig. 9 for Figure 1 Schematic diagram of the structure at C in the middle; Fig.10 for Figure 4 Schematic diagram of the structure at D in the middle; Fig.11 It is a schematic diagram of the position of the heat-conducting ribs of the present invention; Fig.12 for Fig.11 Schematic diagram of the structure at point E in the middle.

[0021] In the accompanying drawings, the components represented by the reference numerals are listed as follows: 100-mixing box, 101-feeding cylinder, 102-dividing slot, 103-connecting slot, 104-dividing pipe, 105-feeding port, 106-fixing block, 107-rotating shaft, 108-rotating plate; 200- partition, 201- rotating ring seat, 202- first gear ring, 203- annular boss, 204- sliding groove; 300-heating box, 301-screw, 302-lifting seat, 303-connecting frame, 304-lifting ring plate, 305-first heater, 306-second heater, 307-support seat; 400 - rotating material storage assembly, 401 - material storage barrel, 402 - annular top plate, 403 - heat-conducting ribs, 404 - central tube, 405 - air vents, 406 - spring groove, 407 - sealing ring; 500-driving assembly, 501-driving bevel gear, 502-rotating ring plate, 503-second gear ring, 504-driving bevel gear ring; 600-fixed stirring assembly, 601-exhaust pipe, 602-annular pipe, 603-fixed pipe, 604-stirring plate, 605-sealing plate; 700-sealing assembly, 701-sealing plug, 702-spring plate, 703-first electromagnet, 704-second electromagnet; 800-feeding assembly, 801-feeding ring pipe, 802-rotating pipe, 803-adjusting gear, 804-adjusting gear ring, 805-feeding guide pipe, 806-feeding trough. DETAILED DESCRIPTION

[0022] The technical solutions in the embodiments of the present invention will be clearly and completely described below in conjunction with the drawings in the embodiments of the present invention. Obviously, the described embodiments are only part of the embodiments of the present invention, rather than all the embodiments. Based on the embodiments of the present invention, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of the present invention.

[0023] Embodiment 1, please refer to the attached drawings, the present invention provides a technical solution: A drug purification device for biopharmaceutical processing, such as Figure 1 As shown, it includes a cylindrical mixing box 100 and a heating box 300 located at the bottom of the mixing box 100, the inner side wall and the bottom of the heating box 300 are respectively provided with a first heater 305 and a second heater 306, and a drain pipe and a valve are provided on one side of the bottom of the heating box 300; A circular partition 200 is fixed between the mixing box 100 and the heating box 300, a lifting assembly and a horizontal lifting ring plate 304 are provided at the bottom center of the partition 200, a plurality of rotating material storage assemblies 400 are evenly arranged and rotatably connected along the circumferential direction on the lifting ring plate 304, the top of the rotating material storage assembly 400 passes through the partition 200 and extends into the mixing box 100, a driving assembly 500 is provided at the lower part of the inner cavity of the mixing box 100, and the driving assembly 500 is correspondingly connected to the plurality of rotating material storage assemblies 400; Each rotating material storage assembly 400 is provided with a fixed stirring assembly 600, the top end of the fixed stirring assembly 600 extends out of the rotating material storage assembly 400, and is fixedly connected to the top of the mixing box 100 through an air guide structure, and the top end of the air guide structure extends out of the mixing box 100; A feeding assembly is provided in the middle of the top of the mixing box 100, a plurality of drop openings 105 are evenly arranged at the bottom of the feeding assembly along the circumferential direction, and a sealing assembly 700 is provided in the feeding assembly, a discharge assembly 800 is provided on the upper part of the inner wall of the heating box 300, and the bottoms of the plurality of rotating storage assemblies 400 are correspondingly connected to the discharge assembly 800.

[0024] When extracting and processing liquid pharmaceutical materials, materials are added to the multiple rotating material storage components 400 in the mixing box 100 through the feeding component, and the rotating material storage components 400 are rotated relative to the fixed stirring component 600 through the driving component 500, so as to stir and mix the liquid in the rotating material storage component 400, so as to fully mix the liquid and the corresponding treatment agent, etc., and improve the treatment effect; After the mixing is completed, the lifting ring plate 304 is used to drive the multiple rotating storage assemblies 400 to move downward through the lifting assembly, so that the lower and middle parts of the rotating storage assemblies 400 are located in the hot water in the heating box 300, and the hot water is heated by the first heater 305 and the second heater 306, and then the materials in the rotating storage assemblies are fully heated by the hot water and kept at a certain temperature condition for reaction and purification. Among them, when the rotating storage assemblies 400 are located in the heating box 300, the multiple rotating storage assemblies 400 are rotated by the driving assembly 500 at the same time, so as to fully contact with the hot water and improve the heating effect.

[0025] When multiple rotating storage assemblies 400 are located in the heating box 300, their tops are located at the bottom of the fixed stirring assembly 600, and the tops of the rotating storage assemblies 400 are closed by the bottom of the fixed stirring assembly 600, so that the gases generated by heating in the rotating storage assemblies 400 can enter the gas guide structure in the fixed stirring assembly 600 for discharge.

[0026] When the mixing and purification process is completed, the lifting assembly and the lifting ring plate 304 drive the multiple rotating storage assemblies 400 to move upward, and then open the bottom of the rotating storage assembly 400 to allow the material therein to be discharged and fall into the unloading assembly 800 for discharge. After the discharge is completed, the rotating storage assembly 400 is closed for the next feeding and purification process.

[0027] The present invention reduces the processing volume in each rotating storage assembly 400 by loading the purified material into a plurality of rotating storage assemblies 400 in equal portions, and enables the material in each rotating storage assembly 400 to be fully mixed and processed through the cooperation of the rotating storage assembly 400 and the fixed stirring assembly 600; and after the rotating storage assembly 400 enters the heating box 300, the portion processing method can increase the contact area between the entire liquid material and the hot water, thereby improving the thermal conductivity and heating efficiency.

[0028] The present invention provides a material unloading assembly 800 so that materials in a plurality of rotating material storage assemblies 400 can be unloaded in a centralized manner, which is convenient for collection and processing.

[0029] Among them, Figure 4 As shown, the rotating material storage assembly 400 includes a material storage barrel 401 rotatably connected to the lifting ring plate 304, a vertical central tube 404 is fixed at the center of the bottom surface of the material storage barrel 401, and a discharge port and a valve are provided on one side of the bottom, the top of the central tube 404 is located at the upper part of the inner cavity of the material storage barrel 401, and an air hole 405 is provided at the center of the top, so that when the material storage barrel 401 and the central tube 404 move down to the hot water in the heating box 300, the internal air pressure of the central tube 404 is consistent with that of the outside, and the hot water can smoothly enter the central tube 404 to avoid the generation of negative pressure, etc. Figure 3 As shown, a ring-shaped top plate 402 is fixed to the top of the storage barrel 401. Fig.11 As shown, a plurality of vertical heat-conducting ribs 403 are evenly fixed to the bottom of the annular top plate 402 along the circumferential direction, the inner side of the heat-conducting ribs 403 is fixedly connected to the outer side wall of the storage barrel 401, the bottom end is located at the lower part of the outer side wall of the storage barrel 401, and the storage barrel 401 is correspondingly connected to the driving assembly 500 through the heat-conducting ribs 403; like Figure 2 As shown, the position corresponding to each storage barrel 401 on the partition 200 is rotatably connected to a rotating ring seat 201, and the storage barrel 401 is slidably connected to the rotating ring seat 201, as shown in FIG. Fig.12 As shown, a sliding groove 204 is provided on the inner wall of the rotating ring seat 201 corresponding to the position of each heat-conducting rib 403, and the heat-conducting rib 403 is slidably connected in the sliding groove 204. A first gear ring 202 is fixed to the outer side of the rotating ring seat 201, and multiple first gear rings 202 are correspondingly connected to the driving assembly 500.

[0030] After the liquid material enters the storage barrel 401, the driving assembly 500 rotates the plurality of first gear rings 202, and the sliding grooves 204 and the heat-conducting ribs 403 act to rotate the storage barrel 401 accordingly, and rotate relative to the fixed stirring assembly 600, thereby achieving relative movement and stirring of the liquid material, thereby improving the stirring and mixing effect; When the materials are mixed, the lifting ring plate 304 is used to drive the multiple storage barrels 401 to move downward through the lifting component, so that the outer wall of the storage barrel 401, the heat-conducting ribs 403 and the inner wall of the central tube 404 are in contact with the hot water, thereby increasing the contact area with the hot water and improving the heating effect and heating speed of the liquid material. The storage barrel 401 can be rotated by the driving component 500, so that the heat-conducting ribs 403 are in full contact with the hot water, thereby improving the heat conduction effect.

[0031] Among them, Figure 4 , Figure 5 As shown, the fixed stirring assembly 600 includes a fixed tube 603 slidably connected to the outside of the central tube 404, the top of the fixed tube 603 is fixedly connected to the air guide structure, the bottom end is close to the bottom of the inner cavity of the storage barrel 401, and is fixed with an annular sealing plate 605, and the position of the sealing plate 605 corresponds to the position of the annular top plate 402, and a plurality of stirring plates 604 are evenly fixed on the outside of the fixed tube 603 along the circumferential direction, and the outer side of the stirring plate 604 is located in the inner hole area of ​​the annular top plate 402; like Figure 4 As shown, the air guide structure includes an annular tube 602 fixed to the top of the inner cavity of the mixing box 100, the top ends of multiple fixed tubes 603 are fixedly connected to the bottom of the annular tube 602, a vertical exhaust pipe 601 is fixed to the top of the annular tube 602, and the top end of the exhaust pipe 601 passes through and extends out of the mixing box 100.

[0032] During the rotation of the storage barrel 401, the stirring plate 604 rotates relative to the storage barrel 401 so as to stir and mix the materials in the storage barrel 401; when the storage barrel 401 moves downward for heating treatment, the sealing plate 605 is located at the top of the storage barrel 401 and contacts the bottom of the annular top plate 402, thereby sealing the top of the storage barrel 401, and then the gas materials generated by the heating in the storage barrel 401 enter the annular tube 602 and the exhaust pipe 601 in the gas guide structure through the fixed tube 603, and then are discharged, thereby preventing the gas from directly entering the mixing box 100.

[0033] Among them, Figure 8 As shown, the driving assembly 500 includes an annular boss 203 fixed to the top of the partition 200, and a rotating ring plate 502 is rotatably connected to the annular boss 203. A second gear ring 503 is fixed to the inner side of the rotating ring plate 502. Multiple first gear rings 202 are meshed with the inner side of the second gear ring 503. A transmission bevel gear ring 504 is fixed to the outer surface of the rotating ring plate 502. A driving bevel gear 501 is rotatably connected to the inner wall of the mixing box 100, and the driving bevel gear 501 is meshed with the transmission bevel gear ring 504, and the outer end of the driving bevel gear 501 is connected to a motor.

[0034] When the storage barrel 401 needs to rotate, the driving bevel gear 501 is rotated by the motor, and the rotating ring plate 502 and the second gear ring 503 are driven to rotate through the transmission bevel gear ring 504, thereby driving the multiple first gear rings 202 and the rotating ring seat 201 to rotate, and then through the action of the sliding groove 204 and the heat-conducting ribs 403, the storage barrel 401 rotates with the rotating ring seat 201 and rotates relative to the fixed stirring assembly 600, so as to stir and mix the materials in the storage barrel 401.

[0035] Among them, Fig. 9 As shown, the material discharge assembly 800 includes a material discharge ring tube 801 fixed on the upper part of the inner wall of the heating box 300, the material discharge ring tube 801 is connected to a discharge pipe, and one end of the discharge pipe extends out of the heating box 300, the top of the material discharge ring tube 801 is evenly arranged and rotatably connected with a plurality of vertical rotating tubes 802 in the circumferential direction, one side of the rotating tube 802 is connected and fixed with a material guide tube 805, one end of the material guide tube 805 is located below the discharge port of the storage barrel 401, and is connected and fixed with a material receiving trough 806, an adjusting gear 803 is fixed on the top of the rotating tube 802, an adjusting gear ring 804 is rotatably connected on the inner wall of the heating box 300, a plurality of adjusting gears 803 are meshed with the adjusting gear ring 804, and a micro motor is connected to the top of one of the adjusting gears 803.

[0036] When the storage barrel 401 and other structures need to be moved, the multiple rotating tubes 802 are rotated at the same time through the drive of the micro motor and the transmission of the adjusting gear ring 804 and multiple adjusting gears 803, and the corresponding material guide pipes 805 and the material receiving trough 806 are driven to rotate, so that the positions of the structures such as the material receiving trough 806 are staggered with the positions of the lifting ring plate 304, so as to avoid affecting the movement of the lifting ring plate 304 and the structures thereon; after the material in the storage barrel 401 is heated and moved back to its original position, the rotating tube 802 drives the material guide pipe 805 and the material receiving trough 806 to rotate through the micro motor and other structures, so that the material receiving trough 806 rotates to the bottom of the discharge port of the storage barrel 401, and then the valve of the discharge port is opened to make the material in the storage barrel 401 fall into the material receiving trough 806, and enter the discharge ring pipe 801 along the material guide pipe 805 and the rotating tube 802, so as to discharge the materials in multiple storage barrels 401 in a centralized manner.

[0037] Embodiment 2: The structure of this embodiment is basically the same as that of embodiment 1, except that Fig.10 As shown, an annular spring groove 406 is provided at the bottom of the annular top plate 402 corresponding to the position of the sealing plate 605, and a plurality of springs are evenly arranged in the annular groove, and a sealing ring 407 is commonly connected through the bottom ends of the plurality of springs, and the bottom of the sealing ring 407 extends out of the spring groove 406. When the sealing plate 605 moves up and contacts the bottom of the annular top plate 402, the top surface of the sealing plate 605 contacts the sealing ring 407, and during the rotation of the annular top plate 402 and other structures, the spring and the sealing ring 407 maintain contact with the top of the sealing plate 605, thereby improving the sealing performance of the top of the storage barrel 401.

[0038] Embodiment 3: The structure of this embodiment is basically the same as that of embodiment 1, except that Figure 6 As shown, the feeding assembly includes a feeding barrel 101 fixed at the top center of the mixing box 100, the bottom end of the feeding barrel 101 extends into the mixing box 100, and an annular diverter groove 102 is fixed on the outer side of the bottom end, a plurality of connecting grooves 103 are evenly arranged at the bottom of the outer wall of the feeding barrel 101, and are connected with the inner cavity of the diverter groove 102 through the connecting grooves 103, a sealing assembly 700 is arranged at the top of the diverter groove 102, and a plurality of diverter pipes 104 are evenly fixed and connected along the circumferential direction on the outer wall, and the diverter pipes 104 are arranged along the radial direction of the diverter groove 102, and correspond one by one to the positions of the plurality of storage barrels 401, as shown in FIG. Figure 7 As shown, the outer end of the shunt pipe 104 extends to the top of the storage barrel 401 , and a drop opening 105 is provided at the bottom of the outer end corresponding to the inner hole area of ​​the annular top plate 402 .

[0039] A fixing block 106 is provided at the outer end of the shunt tube 104, and is fixed to the outer wall of the fixed tube 603 through the fixing block 106. The connection between the fixing block 106 and the fixed tube 603 improves the position stability of the outer end of the shunt tube 104 and avoids the outer end of the shunt tube 104 from being suspended.

[0040] When it is necessary to feed materials into the multiple storage barrels 401, the shunt groove 102 is opened by the sealing assembly 700, so that the shunt groove 102 is connected with the shunt pipe 104 and the feeding barrel 101, so that the materials put into the feeding barrel 101 can enter the shunt groove 102 along the connecting groove 103, and then enter the multiple shunt pipes 104, and then flow along the shunt pipes 104, and fall into the corresponding storage barrel 401 through the drop port 105, so as to realize the feeding operation of the storage barrel 401; After the loading operation is completed, the diverter slot 102 is closed by the sealing assembly 700, so that the inner end of the diverter tube 104 and the bottom of the feed barrel 101 are closed, so that the storage barrel 401 can suspend the loading of materials and perform mixing and heating and other processes.

[0041] Among them, Figure 6 As shown, the sealing assembly 700 includes an annular sealing plug 701 slidably connected to the upper part of the inner cavity of the diverter groove 102, the top end of the sealing plug 701 extends out of the diverter groove 102, and is fixed with an annular spring plate 702, a plurality of springs are evenly connected between the top of the spring plate 702 and the top of the inner cavity of the mixing box 100, and an annular first electromagnet 703 and a second electromagnet 704 are fixed at relative positions of the spring plate 702 and the top of the inner cavity of the mixing box 100, and the first electromagnet 703 and the second electromagnet 704 are electrically connected to a power supply and a switch.

[0042] When the diverter slot 102 is working, the bottom end of the sealing plug 701 is located at the upper part of the diverter slot 102, so that the ends of the connecting slot 103 and the dividing pipe are connected to the diverter slot 102. When the feeding assembly suspends feeding, the first electromagnet 703 and the second electromagnet 704 are energized to attract each other, so that the spring plate 702 stretches the spring and drives the sealing plug 701 to move downward, so that the bottom end of the sealing plug 701 contacts the bottom surface of the diverter slot 102, and the two side walls of the sealing plug 701 contact the two side walls of the diverter slot 102, thereby closing the diverter slot 102 and separating the diverter pipe 104 and the connecting slot 103, achieving the sealing purpose, and suspending feeding into the feeding barrel 101.

[0043] Embodiment 4: The structure of this embodiment is basically the same as that of embodiment 1, except that Figure 6As shown, a premixing structure is provided in the feed barrel 101, and the premixing structure includes a rotating shaft 107 rotatably connected to the center of the feed barrel 101, the bottom end of the rotating shaft 107 extends out of the bottom end of the feed barrel 101, and is connected to a motor, and a plurality of rotating plates 108 are evenly arranged on the rotating shaft 107 along the circumferential direction. When liquid materials etc. enter the feed barrel 101, the rotating shaft 107 is driven by the motor, and the liquid materials etc. are premixed by the rotation of the rotating shaft 107 and the rotating plates 108.

[0044] Embodiment 5: The structure of this embodiment is basically the same as that of embodiment 1, except that Figure 2 As shown, the lifting assembly includes a vertical screw rod 301 rotatably connected to the center of the bottom of the partition 200, and the top end of the screw rod 301 extends out of the partition 200 and is connected to a motor, such as Figure 3 As shown, an annular support seat 307 is fixed at the center of the bottom of the inner cavity of the heating box 300, and the bottom end of the screw 301 is rotatably connected to the support seat 307, and the upper part of the screw 301 is threadedly connected to the lifting seat 302, and the outer side of the lifting seat 302 is evenly fixed with multiple inclined connecting frames 303 in the circumferential direction, and the outer ends of multiple connecting frames 303 are fixedly connected to the inner ring side of the lifting ring plate 304, and the lifting ring plate 304 is restricted by the relative movement between the storage barrel 401 and the partition 200, and can only move in the vertical direction. The lifting seat 302 is fixed to the lifting ring plate 304 through the connecting frame 303, and is also subject to the same restriction and guiding effect. Therefore, when the motor drives the screw 301 to rotate, the screw 301 drives the lifting seat 302 to move in the vertical direction, thereby driving the lifting ring plate 304 and multiple storage barrels 401 to move for mixing and heating treatment.

[0045] In the description of this specification, the description with reference to the terms "one embodiment", "example", "specific example", etc. means that the specific features, structures, materials or characteristics described in conjunction with the embodiment or example are included in at least one embodiment or example of the present invention. In this specification, the schematic representation of the above terms does not necessarily refer to the same embodiment or example. Moreover, the specific features, structures, materials or characteristics described can be combined in any one or more embodiments or examples in a suitable manner.

[0046] The preferred embodiments of the present invention disclosed above are only used to help illustrate the present invention. The preferred embodiments do not describe all the details in detail, nor do they limit the invention to only specific implementation methods. Obviously, many modifications and changes can be made according to the content of this specification. This specification selects and specifically describes these embodiments in order to better explain the principles and practical applications of the present invention, so that those skilled in the art can understand and use the present invention well. The present invention is limited only by the claims and their full scope and equivalents.

Claims

1. A drug purification device for biopharmaceutical processing, comprising a cylindrical mixing box (100) and a heating box (300) located at the bottom of the mixing box (100), wherein the inner side wall and the bottom of the heating box (300) are respectively provided with a first heater (305) and a second heater (306), and a drainage pipe and a valve are provided on one side of the bottom of the heating box (300), characterized in that: A circular partition (200) is fixed between the mixing box (100) and the heating box (300); a lifting assembly and a horizontal lifting ring plate (304) are provided at the center of the bottom of the partition (200); a plurality of rotating material storage assemblies (400) are evenly arranged and rotatably connected on the lifting ring plate (304) along the circumferential direction; the top of the rotating material storage assembly (400) passes through the partition (200) and extends into the mixing box (100); a driving assembly (500) is provided at the lower part of the inner cavity of the mixing box (100); and the driving assembly (500) is correspondingly connected to the plurality of rotating material storage assemblies (400); Each of the rotating material storage components (400) is provided with a fixed stirring component (600), the top end of the fixed stirring component (600) protrudes from the rotating material storage component (400) and is fixedly connected to the top of the mixing box (100) via an air guide structure, and the top end of the air guide structure protrudes from the mixing box (100); A feeding assembly is provided in the middle of the top of the mixing box (100), a plurality of drop openings (105) are evenly arranged at the bottom of the feeding assembly along the circumferential direction, and a sealing assembly (700) is provided in the feeding assembly, a discharge assembly (800) is provided at the upper part of the inner side wall of the heating box (300), and the bottoms of the plurality of rotating storage assemblies (400) are correspondingly connected to the discharge assembly (800).

2. The drug purification equipment for biopharmaceutical processing according to claim 1, characterized in that: The rotating material storage assembly (400) comprises a material storage barrel (401) rotatably connected to a lifting ring plate (304); a vertical center tube (404) is fixed at the center of the bottom surface of the material storage barrel (401); a discharge port and a valve are provided on one side of the bottom; the top of the center tube (404) is located at the upper part of the inner cavity of the material storage barrel (401); and a vent hole (405) is provided at the center of the top; an annular top plate (402) is fixed at the top of the material storage barrel (401); a plurality of vertical heat-conducting ribs (403) are evenly fixed at the bottom of the annular top plate (402) along the circumferential direction; the inner side edge of the heat-conducting rib (403) is fixedly connected to the outer side wall of the material storage barrel (401); the bottom end is located at the lower part of the outer side wall of the material storage barrel (401); and the material storage barrel (401) is correspondingly connected to the driving assembly (500) via the heat-conducting ribs (403); A rotating ring seat (201) is rotatably connected to a position corresponding to each material storage barrel (401) on the partition (200), and the material storage barrel (401) is slidably connected to the rotating ring seat (201). A sliding groove (204) is provided on the inner side wall of the rotating ring seat (201) at a position corresponding to each heat-conducting rib (403), and the heat-conducting rib (403) is slidably connected to the sliding groove (204). A first gear ring (202) is fixed to the outer side of the rotating ring seat (201), and the plurality of first gear rings (202) are correspondingly connected to the driving assembly (500).

3. The drug purification equipment for biopharmaceutical processing according to claim 2, characterized in that: The fixed stirring assembly (600) comprises a fixed tube (603) slidably connected to the outside of the central tube (404); the top end of the fixed tube (603) is fixedly connected to the air guide structure; the bottom end is close to the bottom of the inner cavity of the storage barrel (401) and is fixed with an annular sealing plate (605); the position of the sealing plate (605) corresponds to the position of the annular top plate (402); a plurality of stirring plates (604) are evenly fixed to the outside of the fixed tube (603) along the circumferential direction; and the outer edges of the stirring plates (604) are located in the inner hole area of ​​the annular top plate (402); The air guide structure comprises an annular tube (602) fixed to the top of the inner cavity of the mixing box (100), the top ends of the plurality of fixed tubes (603) are fixedly connected to the bottom of the annular tube (602), a vertical exhaust pipe (601) is fixed to the top of the annular tube (602), and the top end of the exhaust pipe (601) passes through and protrudes from the mixing box (100).

4. The drug purification equipment for biopharmaceutical processing according to claim 3, characterized in that: An annular spring groove (406) is provided at the bottom of the annular top plate (402) at a position corresponding to the sealing plate (605), a plurality of springs are evenly arranged in the annular groove, and a sealing ring (407) is connected to the bottom ends of the plurality of springs, and the bottom of the sealing ring (407) extends out of the spring groove (406).

5. The drug purification equipment for biopharmaceutical processing according to claim 2, characterized in that: The driving assembly (500) comprises an annular boss (203) fixed to the top of the partition (200); a rotating ring plate (502) is rotatably connected to the annular boss (203); a second gear ring (503) is fixed to the inner side of the rotating ring plate (502); a plurality of first gear rings (202) are meshed with the inner side of the second gear ring (503); a transmission bevel gear ring (504) is fixed to the outer side surface of the rotating ring plate (502); a driving bevel gear (501) is rotatably connected to the inner side wall of the mixing box (100); the driving bevel gear (501) is meshed with the driving bevel gear ring (504); and a motor is connected to the outer end of the driving bevel gear (501).

6. The drug purification equipment for biopharmaceutical processing according to claim 2, characterized in that: The feeding assembly comprises a feeding barrel (101) fixed at the top center of the mixing box (100), the bottom end of the feeding barrel (101) extends into the mixing box (100), and an annular diverter groove (102) is fixed on the outer side of the bottom end, a plurality of connecting grooves (103) are evenly arranged at the bottom of the outer wall of the feeding barrel (101), and are connected with the inner cavity of the diverter groove (102) through the connecting grooves (103), a sealing assembly (700) is arranged at the top of the diverter groove (102), a plurality of diverter pipes (104) are evenly fixed and connected along the circumferential direction on the outer wall, the diverter pipes (104) are arranged along the radial direction of the diverter groove (102), and correspond one by one to the positions of the plurality of storage barrels (401), the outer end of the diverter pipe (104) extends to the top of the storage barrel (401), and a feeding port (105) is arranged at the bottom of the outer end corresponding to the inner hole area of ​​the annular top plate (402).

7. The drug purification equipment for biopharmaceutical processing according to claim 6, characterized in that: The sealing assembly (700) comprises an annular sealing plug (701) slidably connected to the upper part of the inner cavity of the diverter groove (102); the top end of the sealing plug (701) extends out of the diverter groove (102) and is fixed with an annular spring plate (702); a plurality of springs are evenly connected between the top of the spring plate (702) and the top of the inner cavity of the mixing box (100); and an annular first electromagnet (703) and a second electromagnet (704) are respectively fixed at relative positions of the spring plate (702) and the top of the inner cavity of the mixing box (100); the first electromagnet (703) and the second electromagnet (704) are electrically connected to a power supply and a switch.

8. The drug purification equipment for biopharmaceutical processing according to claim 7, characterized in that: The feed barrel (101) is provided with a premixing structure, and the premixing structure comprises a rotating shaft (107) rotatably connected to the center of the feed barrel (101), the bottom end of the rotating shaft (107) protruding from the bottom end of the feed barrel (101) and connected to a motor, and a plurality of rotating plates (108) are evenly arranged on the rotating shaft (107) along the circumferential direction.

9. The drug purification equipment for biopharmaceutical processing according to claim 2, characterized in that: The material discharge assembly (800) comprises a material discharge ring tube (801) fixed to the upper part of the inner wall of the heating box (300), the material discharge ring tube (801) being connected to a material discharge pipe, and one end of the material discharge pipe extending out of the heating box (300), a plurality of vertical rotating tubes (802) being evenly arranged and rotatably connected along the circumferential direction at the top of the material discharge ring tube (801), a material guide tube (805) being connected and fixed to one side of the rotating tube (802), one end of the material guide tube (805) being located below the material discharge port of the material storage barrel (401) and being connected and fixed to a material receiving trough (806), an adjusting gear (803) being fixed to the top of the rotating tube (802), an adjusting gear ring (804) being rotatably connected to the inner wall of the heating box (300), a plurality of adjusting gears (803) being meshed with the adjusting gear ring (804), and a micro motor being connected to the top of one of the adjusting gears (803).

10. The drug purification equipment for biopharmaceutical processing according to any one of claims 1 to 9, characterized in that: The lifting assembly comprises a vertical screw (301) rotatably connected to the center of the bottom of the partition (200), the top end of the screw (301) protrudes from the partition (200) and is connected to a motor, an annular support seat (307) is fixed at the center of the bottom of the inner cavity of the heating box (300), and the bottom end of the screw (301) is rotatably connected to the support seat (307), the upper part of the screw (301) is threadedly connected to a lifting seat (302), and a plurality of inclined connecting frames (303) are evenly fixed to the outer side of the lifting seat (302) along the circumferential direction, and the outer ends of the plurality of connecting frames (303) are fixedly connected to the inner ring side of the lifting ring plate (304).

Images