Non-invasive detection kit for female gestational hypertension gene

Abstract

The invention relates to the field of gene detection kits, in particular to a female gestational hypertension gene noninvasive detection kit which comprises a kit body, a kit cover, a high-elasticity fixing part, a lifting frame and the like, the rear side of the kit cover is rotationally connected with the top of the kit body, the high-elasticity fixing part is located in the kit body, and the lifting frame is located in the kit body. The high-elasticity fixing piece is provided with a plurality of reagent cavities used for storing reagent tubes, the lifting frame is located at the top of the high-elasticity fixing piece, and the high-elasticity fixing piece can be compressed when the lifting frame descends. The opening action of the box cover is converted into the descending motion of the lifting frame through the transmission assembly, then the high-elasticity fixing piece is compressed, space is created for taking out reagent tubes, the taking process is simplified, the operation efficiency is improved, meanwhile, through the combined design of a pressing plate, a telescopic sleeve and a first elastic piece, the operation efficiency is improved, and the labor intensity is reduced. The reagent tubes with various lengths can be adaptively fixed, and the stability of the reagent tubes in the storage process is ensured.

Description

Technical Field

[0001] The present invention relates to the field of gene detection kits, and in particular to a non-invasive detection kit for female gestational hypertension genes. Background Art

[0002] Hypertensive disorder complicating pregnancy is a disease unique to pregnancy. It occurs after 20 weeks of pregnancy and its clinical manifestations include hypertension, proteinuria, edema, and in severe cases, convulsions, coma, and even maternal and infant death. To date, hypertension complicating pregnancy is still an important cause of maternal and perinatal death; therefore, it is particularly important to develop a simple, rapid and accurate non-invasive detection kit for female gestational hypertension susceptibility genes.

[0003] A genetic testing kit is a collection of tools used for genetic testing, which usually includes a reagent tube for storing the sample to be tested (such as blood, other body fluids or cells), and a kit body for loading and transporting the reagent tube. Due to the manufacturing precision or the reagent tube model, the length of the reagent tube varies. The depth of the reagent tube that can be placed in the existing kit is fixed. After the shorter reagent tube is placed, it is located at the bottom of the kit, which is difficult to reach and grab, and it is inconvenient to take.

[0004] The patent with authorization announcement number CN220518933U discloses a new type of lifting gene detection kit. When placing some shorter test tubes, press the control button to open the corresponding solenoid valve, and inflate the airbag through the air pump. The inflated airbag will expand and lift the lifting bottom block. After the lifting bottom block moves up, the starting height can be increased. When placing some shorter test tubes, it is not easy for them to fall into the interior of the kit body, so it is more convenient to take and place.

[0005] However, the device requires placing multiple test tubes of the same length on the same lifting bottom block, and separately operating the lifting of the multiple lifting bottom blocks to keep the tops of all the test tubes at the same height, which is cumbersome and time-consuming. Summary of the invention

[0006] In order to overcome the above-mentioned shortcomings of the prior art, the present invention provides a non-invasive detection kit for female gestational hypertension genes.

[0007] The technical implementation scheme of the present invention is: a non-invasive detection kit for genes of hypertension in pregnancy in women, comprising a box body, a box cover, a highly elastic fixing part, a lifting frame, a transmission assembly, a movable plate and a pressure plate, the rear side of the box cover is rotatably connected to the top of the box body, the highly elastic fixing part is located inside the box body, the highly elastic fixing part has a plurality of reagent cavities for storing reagent tubes, the lifting frame is located on the top of the highly elastic fixing part, and the lifting frame can compress the highly elastic fixing part when it descends, the transmission assembly is arranged on the left and right sides of the box body, and the transmission assembly can drive the lifting frame to descend when the box cover is rotated upward to open, the movable plate is located between the lifting frame and the box cover, a plurality of pressure plates are arranged on the side of the movable plate away from the box cover, and a plurality of pressure plates are arranged corresponding to a plurality of reagent cavities.

[0008] Furthermore, the transmission assembly includes a pulley and a pull rope, at least one of the pulleys is rotatably connected to the left and right sides of the lower inner part of the box body, and the pulleys are also rotatably connected to the left and right sides of the lifting frame, and the pull rope is wound around multiple pulleys on the same side, and the two ends of the pull rope are respectively connected to the lifting frame and the box cover, wherein, when the box cover is rotated upward to open, the end of the pull rope connected to the box cover will be subjected to tension, and this tension is dispersed and transmitted to the pulley on the lifting frame and the end of the pull rope connected to the lifting frame under the guidance of the pulley on the box body, thereby converting it into a downward pulling force on the lifting frame, causing the lifting frame to slide downward and compress the high-elastic fixing member.

[0009] Furthermore, a telescopic sleeve is connected between the pressure plate and the movable plate, and a first elastic member is provided in the telescopic sleeve, wherein the pressure plate maintains contact with the reagent tube stored in the reagent chamber under the extension and contraction of the telescopic sleeve and the elastic action of the first elastic member, thereby fixing the reagent tube.

[0010] Furthermore, a connecting plate is slidably connected to the rear side of the top of the box body, the top of the connecting plate is rotatably connected to the rear side of the movable plate, a fixing block is fixed to the front side of the movable plate, and a card slot matching the fixing block is opened on the front side of the top of the box body.

[0011] Furthermore, the front and rear sides of the box body are slidably connected with a card block, the front card block is located on the left side of the fixed block, and the rear card block is located on the left side of the connecting plate, the connecting plate and the fixed block are both provided with a second card slot matching their respective corresponding card blocks, a second elastic member is connected between the card block and the box body, and the left sides of the two card blocks are commonly connected to the same first pull rod, and the first pull rod is used to synchronously operate the two card blocks, wherein when the card block is engaged with the second card slot, the movement of the connecting plate or the fixed block is restricted, thereby restricting the movement of the movable plate, thereby maintaining the fixing effect of the pressure plate on the reagent tube.

[0012] Furthermore, the distance that the connecting plate can slide up and down relative to the box body is greater than the depth of the first card slot.

[0013] Furthermore, in order to facilitate the operation of the movable plate, a second pull rod is fixedly connected to a side of the movable plate facing away from the box cover.

[0014] Furthermore, the top surface of the highly elastic fixing member after being compressed is at least lower than the top surface of the reagent tube with the shortest length.

[0015] Compared with the prior art, the beneficial effects of the present invention are as follows: through the combined design of the high-elastic fixing part, the lifting frame and the transmission assembly, the opening action of the box cover can be converted into the descending movement of the lifting frame, thereby compressing the high-elastic fixing part, creating space for the removal of the reagent tube, simplifying the retrieval process, and improving the operating efficiency. At the same time, through the combined design of the pressure plate, the telescopic sleeve and the first elastic part, whether it is a longer reagent tube or a shorter reagent tube, it can be firmly fixed through the adaptive adjustment of the pressure plate, thereby improving the safety of the reagent tube during storage. BRIEF DESCRIPTION OF THE DRAWINGS

[0016] Figure 1 It is a schematic diagram of the overall appearance of the present invention.

[0017] Figure 2 It is a three-dimensional exploded view of the movable plate, lifting frame and high-elastic fixing member of the present invention.

[0018] Figure 3 It is a cross-sectional view of the internal structure of the box body of the present invention.

[0019] Figure 4 For the present invention Figure 3 Enlarged view of point A in .

[0020] Figure 5 It is a three-dimensional structural schematic diagram of the lifting frame, pulley and pull rope of the present invention.

[0021] Figure 6 It is a schematic diagram of the three-dimensional structure of the box cover after opening the box cover of the present invention.

[0022] Figure 7 It is a schematic diagram of the three-dimensional structure of the pulley and the pull rope after the lifting frame of the present invention is lowered.

[0023] Figure 8 It is an exploded view of the three-dimensional structure of the connecting plate, the fixing block and the clamping block of the present invention.

[0024] Explanation of the accompanying drawings: 10, box body, 11, box cover, 12, high-elastic fixing part, 121, reagent chamber, 13, lifting frame, 14, pulley, 15, pull rope, 16, movable plate, 17, pressure plate, 20, telescopic sleeve, 21, first elastic part, 30, connecting plate, 31, fixing block, 32, slot one, 40, block, 41, second elastic part, 42, first pull rod, 43, slot two, 50, second pull rod, 60, reagent tube. DETAILED DESCRIPTION

[0025] In order to make the technical problems, technical solutions and beneficial effects to be solved by the present invention more clearly understood, the present invention is further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are only used to explain the present invention and are not intended to limit the present invention.

[0026] Thus, a feature indicated in this specification will be used to illustrate one of the features of an embodiment of the present invention, rather than implying that each embodiment of the present invention must have the described feature. In addition, it should be noted that this specification describes many features. Although some features can be combined together to illustrate possible system designs, these features can also be used in other combinations that are not explicitly described. Thus, unless otherwise stated, the described combinations are not intended to be limiting.

[0027] In the description of the present application, the terms “first” and “second” are used for descriptive purposes only and should not be understood as indicating or implying relative importance.

[0028] In the description of the present application, it should be noted that the terms "center", "up", "down", "left", "right", "vertical", "horizontal", "inside", "outside", etc., indicating orientations or positional relationships, are based on the orientations or positional relationships shown in the accompanying drawings, and are only for the convenience of describing the present application and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, be constructed and operated in a specific orientation, and therefore should not be understood as a limitation on the present application.

[0029] The principle and structure of the present invention are described in detail below with reference to the accompanying drawings and embodiments.

[0030] See also Figure 1-Figure 8The non-invasive detection kit for female gestational hypertension gene provided in this embodiment includes a box body 10, a box cover 11, a high-elastic fixing part 12, a lifting frame 13, a transmission component, a movable plate 16 and a pressing plate 17.

[0031] The rear side of the box cover 11 is rotatably connected to the top of the box body 10, and the high-elastic fixing member 12 is located inside the box body 10. In this embodiment, the high-elastic fixing member 12 is made of high-elastic sponge with high resilience, compressibility and durability.

[0032] The highly elastic fixing part 12 has a reagent chamber 121, wherein there are multiple reagent chambers 121, and the multiple reagent chambers 121 are sequentially spaced apart in the highly elastic fixing part 12. Specifically, the size and shape of the reagent chamber 121 match the reagent tube 60 to ensure that the reagent tube 60 can be stably placed therein.

[0033] The lifting frame 13 is located on the top of the high-elastic fixing part 12. The lifting frame 13 is in the shape of a well so as not to affect the placement of the reagent tube 60 in the reagent chamber 121. The transmission assembly is arranged on the left and right sides of the box body 10. The transmission assembly can drive the lifting frame 13 to move downward when the box cover 11 is rotated upward to open. When the lifting frame 13 descends, the high-elastic fixing part 12 can be compressed. The top surface of the high-elastic fixing part 12 after compression is at least lower than the top surface of the reagent tube 60 with the shortest length, so as to ensure that after the high-elastic fixing part 12 is compressed, space can be created for taking out all reagent tubes 60 of different lengths.

[0034] The movable plate 16 is located between the lifting frame 13 and the box cover 11. A plurality of pressing plates 17 of the same number as the reagent chamber 121 are arranged on the side of the movable plate 16 facing away from the box cover 11. The shape and size of the pressing plate 17 are adapted to the opening of the reagent chamber 121 to ensure that the pressing plate 17 can be inserted into the reagent chamber 121 to resist the shorter reagent tube 60 placed in the reagent chamber 121. The pressing plate 17 can be made of rubber, silicone or other materials. In the present embodiment, the pressing plate 17 is made of rubber to ensure that when the pressing plate 17 resists the reagent tube 60, the pressing plate 17 will not cause damage to the reagent tube 60.

[0035] The transmission assembly includes a pulley 14 and a pull rope 15. Two pulleys 14 are rotatably connected to the left and right sides of the lower part of the box body 10. At the same time, a pulley 14 is also rotatably connected to the left and right sides of the lifting frame 13. A pull rope 15 is continuously snaked around the three pulleys 14 on the same side. The two ends of the pull rope 15 are respectively connected to the lifting frame 13 and the box cover 11. When the box cover 11 is rotated upward to open, one end of the pull rope 15 connected to the box cover will be subjected to tension. Since the pulley has the characteristic of changing the direction of the force without changing the magnitude of the force, the tension is dispersed and transmitted to the pulley 14 on the lifting frame 13 and the end of the pull rope 15 connected to the lifting frame 13, thereby converting it into a downward pulling force on the lifting frame 13, causing the lifting frame 13 to slide downward and compress the high-elastic fixing member 12.

[0036] A telescopic sleeve 20 is connected between the pressing plate 17 and the movable plate 16, and a first elastic member 21 is arranged in the telescopic sleeve 20. In this embodiment, the first elastic member 21 is a spring, and the two ends of the first elastic member 21 are respectively connected to the inner top of the telescopic sleeve 20 and the pressing plate 17, and the first elastic member 21 provides a reset force for the pressing plate 17. When the reagent tube 60 is located in the reagent chamber 121 and the movable plate 16 is above the lifting frame 13, the pressing plate 17 maintains contact with the top of the reagent tube 60 under the elastic action of the telescopic sleeve 20 and the first elastic member 21. Specifically, for a reagent tube 60 with a longer length, the pressing plate 17 is subjected to the force of the reagent tube 60, so that the telescopic sleeve The tube 20 and the first elastic member 21 contract, wherein the first elastic member 21 can be deformed according to the magnitude of the force, so that when the pressure plate 17 abuts against the reagent tube 60, the telescopic sleeve 20 and the first elastic member 21 can adaptively adjust the deformation amount according to the length of the reagent tube 60, so that the pressure plate 17 fixes the reagent tube 60 without damaging the reagent tube 60. At the same time, for the reagent tube 60 with a shorter length, the pressure plate 17 can be inserted into the reagent cavity 121 and abut against the reagent tube 60, thereby fixing the reagent tube 60, so that all the reagent tubes 60 can be fixed in the reagent cavity 121 more stably to prevent the reagent tube 60 from moving up and down relative to the reagent cavity 121.

[0037] The top rear side of the box body 10 is slidably connected with a connecting plate 30, and the top of the connecting plate 30 is rotatably connected to the rear side of the movable plate 16, and the front side of the movable plate 16 is fixedly connected with a fixing block 31, and the top front side of the box body 10 is provided with a card slot 32 matching the fixing block 31, wherein, under the guidance of the connecting plate 30 and the fixing block 31, the movable plate 16 can move upward or downward smoothly relative to the box body 10, so that the pressing plate 17 can be inserted into or leave the reagent chamber 121 in the vertical direction, thereby making the fixing or releasing operation of the pressing plate 17 on the reagent tube 60 smoother. In addition, the distance that the connecting plate 30 can slide up and down relative to the box body 10 is greater than the depth of the card slot 32, so that when the fixing block 31 is separated from the card slot 32, the connecting plate 30 still remains connected to the box body 10, and at the same time, the rear side of the movable plate 16 can rotate around the top of the connecting plate 30 to expose the reagent tube 60 under the movable plate 16.

[0038] Since the movable plate 16 can move up and down relative to the top of the box body 10 through the connecting plate 30 and the fixing block 31, when the pressing plate 17 contacts the top of the reagent tube 60, the longer reagent tube 60 will exert a reaction force on the pressing plate 17, so that the movable plate 16 will move upward as a whole, resulting in a reduction in the contact pressure between the pressing plate 17 and the shorter reagent tube 60 or a complete loss of contact, thereby affecting the fixing effect of the shorter reagent tube 60. Therefore, in order to improve the above problem, the pressing plate 17 can fix all lengths of the reagent tube 60. 0 is kept well fixed, the front and rear sides of the box body 10 are slidably connected with a card block 40, the front card block 40 is located on the left side of the fixed block 31, and the rear card block 40 is located on the left side of the connecting plate 30. The connecting plate 30 and the fixed block 31 are both provided with a card slot 43 matching the corresponding card block 40, and a second elastic member 41 is connected between the card block 40 and the box body 10. In this embodiment, the second elastic member 41 is a spring, and the second elastic member 41 provides a reset force for the card block 40. The left sides of the two card blocks 40 are commonly connected with the same first pull rod 42.

[0039] Among them, when the movable plate 16 is in a fixed position, the block 40 is completely stuck in the second slot 43 of the connecting plate 30 and the fixed block 31 under the elastic action of the second elastic member 41, thereby preventing the movable plate 16 from moving up under the reaction force of the reagent tube 60. In this way, no matter how long the reagent tube 60 is, the pressure plate 17 can maintain stable fixation of the reagent tube 60. When the movable plate 16 needs to be moved, the first pull rod 42 is pulled to the left to make the two blocks 40 slide out of the corresponding second slot 43 synchronously, thereby releasing the lock of the movable plate 16. At the same time, the second elastic member 41 is compressed to store elastic potential energy for the subsequent resetting of the block 40.

[0040] A second pull rod 50 is fixedly connected to a side of the movable plate 16 facing away from the box cover 11 . The second pull rod 50 is located in the middle of the movable plate 16 , so that the operation of lifting the movable plate 16 upward by the second pull rod 50 is more stable.

[0041] Working principle: Initially, the box cover 11 is in a closed state, the lifting frame 13 is in the highest position, the high-elastic fixing member 12 is not compressed, the reagent tube 60 is in the reagent chamber 121 of the high-elastic fixing member 12, the fixing block 31 is in the card slot 1 32, and the card block 40 is completely stuck in the card slot 2 43 of the connecting plate 30 and the fixing block 31 under the elastic action of the second elastic member 41. The pressing plate 17 maintains contact with the top of the reagent tube 60 under the elastic action of the telescopic sleeve 20 and the first elastic member 21. Specifically, for a reagent tube 60 with a longer length, the pressing plate 17 is subjected to the force of the reagent tube 60. , causing the telescopic sleeve 20 and the first elastic member 21 to contract, wherein the first elastic member 21 can be deformed according to the magnitude of the force, so that when the pressure plate 17 abuts against the reagent tube 60, the telescopic sleeve 20 and the first elastic member 21 can adaptively adjust the deformation amount according to the length of the reagent tube 60, so that the pressure plate 17 fixes the reagent tube 60 without damaging the reagent tube 60. At the same time, for reagent tubes 60 with shorter lengths, the pressure plate 17 can be inserted into the reagent cavity 121 and abut against the reagent tube 60, thereby fixing the reagent tube 60, so that all reagent tubes 60 can be fixed relatively stably.

[0042] When the reagent tube 60 needs to be taken out, the user turns the box cover 11 upward to open it. At this time, the box cover 11 is driven by the transmission assembly composed of the pull rope 15 and the plurality of pulleys 14, and the opening action of the box cover 11 is converted into the descending movement of the lifting frame 13, and then the high-elastic fixing member 12 is compressed by the lifting frame 13. As the lifting frame 13 descends, the high-elastic fixing member 12 is compressed until its top surface is lower than the top surface of the shortest reagent tube 60, creating space for the removal of the reagent tube 60. Then, the user pulls the first pull rod 42 outward, and the first pull rod 42 drives the two card blocks 40 to move, so that they are out of the engaged state with the card slot 2 43 of the connecting plate 30 and the fixing block 31. Then, the user pulls the second pull rod upward. 50, so that the movable plate 16 drives the fixed block 31 and the connecting plate 30 to move upward relative to the box body 10 until the fixed block 31 is completely separated from the card slot 32 at the top of the box body 10. During this process, the pressure plate 17 is separated from the top of the reagent tube 60, and the card block 40 on the rear side remains in contact with the connecting plate 30, and the card block 40 on the front side is kept contracted in the box body 10 through the first pull rod 42. The two second elastic members 41 are both compressed to store elastic potential energy for the subsequent resetting of the card block 40. After that, the user rotates the movable plate 16 around the top of the connecting plate 30 toward the side of the box cover 11 until the movable plate 16 is in contact with the box cover 11. At this time, all the reagent tubes 60 are exposed, so that the user can easily take them out for use.

[0043] After use, the user places the reagent tube 60 back into the reagent chamber 121. Reagent tubes 60 of different lengths can be placed in any reagent chamber 121. After placement, the user rotates the movable plate 16 in the opposite direction to make it horizontally above the box body 10, and then pushes the movable plate 16 downward to drive the fixed block 31 and the connecting plate 30 to move downward relative to the box body 10 until the fixed block 31 is completely inserted into the card slot 1 32. When the connecting plate 30 and the card slot 2 43 of the fixed block 31 return to the initial position, the card block 40 is in the second elastic member 4 1 automatically snaps into the second slot 43 of the connecting plate 30 and the fixing block 31 under the elastic action of the high-elastic fixing member 12, ensuring the stability of the movable plate 16. During this process, the pressing plate 17 contacts the top of the reagent tube 60 again under the elastic force of the telescopic sleeve 20 and the first elastic member 21, and is fixed again. Finally, the user turns the box cover 11 downward to close the reagent kit, and the pull rope 15 is gradually relaxed. At this time, the elastic restoring force of the high-elastic fixing member 12 is greater than the pulling force of the pull rope 15, and the high-elastic fixing member 12 gradually returns to its original state and drives the lifting frame 13 to rise to the initial position.

[0044] In summary, the present invention not only achieves stable storage of the reagent tube 60, but also simplifies the process of taking the reagent tube 60, thereby improving operational efficiency.

[0045] Although the present disclosure has been described with respect to only a limited number of embodiments, those skilled in the art having benefit of this disclosure will appreciate that various other embodiments can be devised without departing from the scope of the present invention. Accordingly, the scope of the present invention should be limited only by the appended claims.

Claims

1. A non-invasive gene detection kit for female gestational hypertension, comprising a box body (10) and a box cover (11), wherein the rear side of the box cover (11) is rotatably connected to the top of the box body (10), wherein: Also included are: A highly elastic fixing member (12), the highly elastic fixing member (12) being located inside the box body (10), the highly elastic fixing member (12) having a plurality of reagent cavities (121) for storing reagent tubes (60); A lifting frame (13), the lifting frame (13) being located on top of the highly elastic fixing member (12), and the lifting frame (13) being able to compress the highly elastic fixing member (12) when descending; A transmission assembly, the transmission assembly being arranged on the left and right sides of the box body (10), and the transmission assembly being capable of driving the lifting frame (13) to move downward when the box cover (11) is rotated upward to open; A movable plate (16), the movable plate (16) being located between the lifting frame (13) and the box cover (11); A plurality of pressing plates (17), wherein the plurality of pressing plates (17) are arranged on a side of the movable plate (16) facing away from the box cover (11), and the plurality of pressing plates (17) are arranged corresponding to the plurality of reagent chambers (121).

2. The non-invasive detection kit for female gestational hypertension gene according to claim 1, characterized in that: The transmission assembly comprises a pulley (14) and a pull rope (15); at least one pulley (14) is rotatably connected to both left and right sides of the lower inner portion of the box body (10); the pulleys (14) are also rotatably connected to both left and right sides of the lifting frame (13); the pull rope (15) is wound around a plurality of pulleys (14) on the same side; and two ends of the pull rope (15) are respectively connected to the lifting frame (13) and the box cover (11).

3. The non-invasive detection kit for female gestational hypertension gene according to claim 2, characterized in that: A telescopic sleeve (20) is connected between the pressing plate (17) and the movable plate (16), and a first elastic member (21) is provided in the telescopic sleeve (20).

4. The non-invasive detection kit for female gestational hypertension gene according to claim 3, characterized in that: A connecting plate (30) is slidably connected to the rear side of the top of the box body (10); the top of the connecting plate (30) is rotatably connected to the rear side of the movable plate (16); a fixing block (31) is fixedly connected to the front side of the movable plate (16); and a slot (32) matching the fixing block (31) is formed on the front side of the top of the box body (10).

5. The non-invasive detection kit for female gestational hypertension gene according to claim 4, characterized in that: The front and rear sides of the box body (10) are both slidably connected with a clamping block (40), the front clamping block (40) is located on the left side of the fixed block (31), and the rear clamping block (40) is located on the left side of the connecting plate (30), the connecting plate (30) and the fixed block (31) are both provided with a second clamping groove (43) matching the corresponding clamping block (40), a second elastic member (41) is connected between the clamping block (40) and the box body (10), and the left sides of the two clamping blocks (40) are commonly connected to the same first pull rod (42).

6. The non-invasive detection kit for female gestational hypertension gene according to claim 5, characterized in that: The distance that the connecting plate (30) can slide up and down relative to the box body (10) is greater than the depth of the first card slot (32).

7. The non-invasive gene detection kit for female gestational hypertension according to claim 6, characterized in that: A second pull rod (50) is fixedly connected to a surface of the movable plate (16) facing away from the box cover (11).

8. The non-invasive gene detection kit for female gestational hypertension according to claim 7, characterized in that: The top surface of the highly elastic fixing member (12) after being compressed is at least lower than the top surface of the reagent tube (60) with the shortest length.

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